449
Views
59
CrossRef citations to date
0
Altmetric
Research Articles

Folic acid receptor-targeted solid lipid nanoparticles to enhance cytotoxicity of letrozole through induction of caspase-3 dependent-apoptosis for breast cancer treatment

, &
Pages 397-407 | Received 23 Jul 2019, Accepted 09 Dec 2019, Published online: 02 Jan 2020

References

  • Abolmaali SS, Tamaddon AM, Mohammadi S, Amoozgar Z, Dinarvand R. 2016. Chemically crosslinked nanogels of PEGylated poly ethyleneimine (l-histidine substituted) synthesized via metal ion coordinated self-assembly for delivery of methotrexate: cytocompatibility, cellular delivery and antitumor activity in resistant cells. Mater Sci Eng C. 62:897–907.
  • Abubakar IB, Lim K-H, Kam T-S, Loh H-S. 2017. Enhancement of apoptotic activities on brain cancer cells via the combination of γ-tocotrienol and jerantinine A. Phytomedicine. 30:74–84.
  • Ahamed M, Siddiqui MA, Akhtar MJ, Ahmad I, Pant AB, Alhadlaq HA. 2010. Genotoxic potential of copper oxide nanoparticles in human lung epithelial cells. Biochem Biophys Res Commun. 396(2):578–583.
  • Aj MZ, Patil SK, Baviskar DT, Jain DK. 2012. Implantable drug delivery system: a review. In: Grumezescu A, editor. Nanostructures for the Engineering of Cells, Tissues and Organs. 1st ed. Elsevier; p. 473–501.
  • Alemrayat B, Elhissi A, Younes HM. 2019. Preparation and characterization of letrozole-loaded poly (d, l-lactide) nanoparticles for drug delivery in breast cancer therapy. Pharm Develop Technol. 24(2):235–242.
  • Ali A, Ahmed S. 2018. A review on chitosan and its nanocomposites in drug delivery. Int J Biol Macromol. 109:273–286.
  • Anirudhan TS, Christa J. 2018. pH and magnetic field sensitive folic acid conjugated protein–polyelectrolyte complex for the controlled and targeted delivery of 5-fluorouracil. J Industr Eng Chem. 57:199–207.
  • Apaolaza PS, Del Pozo-Rodríguez A, Torrecilla J, Rodríguez-Gascón A, Rodríguez JM, Friedrich U, Weber BHF, Solinís MA. 2015. Solid lipid nanoparticle-based vectors intended for the treatment of X-linked juvenile retinoschisis by gene therapy: in vivo approaches in Rs1h-deficient mouse model. J Controlled Release. 217:273–283.
  • Azandaryani AH, Kashanian S, Derakhshandeh K. 2017. Folate Conjugated hybrid nanocarrier for targeted letrozole delivery in breast cancer treatment. Pharm Res. 34(12):2798–2808.
  • Boulay A, Rudloff J, Ye J, Zumstein-Mecker S, O'Reilly T, Evans DB, Chen S, Lane HA. 2005. Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer. Clin Cancer Res. 11(14):5319–5328.
  • Burra M, Jukanti R, Janga K.Y, Sunkavalli S, Velpula A, Ampati S, Jayaveera KN. 2013. Enhanced intestinal absorption and bioavailability of raloxifene hydrochloride via lyophilized solid lipid nanoparticles. Adv Powder Technol. 24(1):393–402.
  • Chen Q, Zheng J, Yuan X, Wang J, Zhang L. 2018. Folic acid grafted and tertiary amino based pH-responsive pentablock polymeric micelles for targeting anticancer drug delivery. Mater Sci Eng C. 82:1–9.
  • Chen Y, Tezcan O, Li D, Beztsinna N, Lou B, Etrych T, Ulbrich K, Metselaar JM, Lammers T, Hennink WE. 2017. Overcoming multidrug resistance using folate receptor-targeted and pH-responsive polymeric nanogels containing covalently entrapped doxorubicin. Nanoscale. 9(29):10404–10419.
  • De Jesus M.B, Zuhorn I.S. 2015. Solid lipid nanoparticles as nucleic acid delivery system: properties and molecular mechanisms. J Controlled Release. 201:1–13.
  • Depau L, Brunetti J, Falciani C, Scali S, Riolo G, Mandarini E, Pini A, Bracci L. 2017. Coupling to a cancer-selective heparan-sulfate-targeted branched peptide can by-pass breast cancer cell resistance to methotrexate. Oncotarget. 8(44):76141.
  • Dhanasekaran S, Biswal BK, Sumantran VN, Verma RS. 2013. Augmented sensitivity to methotrexate by curcumin induced overexpression of folate receptor in KG-1 cells. Biochimie. 95(8):1567–1573.
  • Doktorovova S, Souto E.B, Silva A.M. 2014. Nanotoxicology applied to solid lipid nanoparticles and nanostructured lipid carriers–a systematic review of in vitro data. Eur J Pharm Biopharm. 87(1):1–18.
  • Dudhipala N, Veerabrahma K. 2016. Candesartan cilexetil loaded solid lipid nanoparticles for oral delivery: characterization, pharmacokinetic and pharmacodynamic evaluation. Drug Deliv. 23(2):395–404.
  • Dutta T, Jain NK, McMillan NAJ, Parekh HS. 2010. RETRACTED: dendrimer nanocarriers as versatile vectors in gene delivery. Nanomed: Nanotechnol Biol Med. 6(1):25–34.
  • Elzoghby AO, Mostafa SK, Helmy MW, ElDemellawy MA, Sheweita SA. 2017a. Multi-reservoir phospholipid shell encapsulating protamine nanocapsules for co-delivery of letrozole and celecoxib in breast cancer therapy. Pharm Res. 34(9):1956–1969.
  • Elzoghby AO, Mostafa SK, Helmy MW, ElDemellawy MA, Sheweita SA. 2017b. Superiority of aromatase inhibitor and cyclooxygenase-2 inhibitor combined delivery: hyaluronate-targeted versus PEGylated protamine nanocapsules for breast cancer therapy. Int J Pharm. 529(1–2):178–192.
  • Fakai MI, Malek SNA, Karsani SA. 2019. Induction of apoptosis by chalepin through phosphatidylserine externalisations and DNA fragmentation in breast cancer cells (MCF7). Life Sci. 220:186–193.
  • Ferrati S, Fine D, You J, De Rosa E, Hudson L, Zabre E, Hosali S, Zhang L, Hickman C, Sunder Bansal S, et al. 2013. Leveraging nanochannels for universal, zero-order drug delivery in vivo. J Controlled Release. 172(3):1011–1019.
  • Fung LK, Saltzman WM. 1997. Polymeric implants for cancer chemotherapy. Adv Drug Delivery Rev. 26(2–3):209–230.
  • Gainza G, Pastor M, Aguirre JJ, Villullas S, Pedraz JL, Hernandez RM, Igartua M. 2014. A novel strategy for the treatment of chronic wounds based on the topical administration of rhEGF-loaded lipid nanoparticles: in vitro bioactivity and in vivo effectiveness in healing-impaired db/db mice. J Controlled Release. 185:51–61.
  • Gansukh E, Mya KK, Jung M, Keum Y-S, Kim DH, Saini RK. 2019. Lutein derived from marigold (Tagetes erecta) petals triggers ROS generation and activates Bax and caspase-3 mediated apoptosis of human cervical carcinoma (HeLa) cells. Food Chem Toxicol. 127:11.
  • Garg NK, Singh B, Jain A, Nirbhavane P, Sharma R, Tyagi RK, Kushwah V, Jain S, Katare OP. 2016. Fucose decorated solid-lipid nanocarriers mediate efficient delivery of methotrexate in breast cancer therapeutics. Colloids Surfaces B: Biointerf. 146:114–126.
  • Gomathi T, Sudha PN, Florence JAK, Venkatesan J, Anil S. 2017. Fabrication of letrozole formulation using chitosan nanoparticles through ionic gelation method. Int J Biol Macromol. 104:1820–1832.
  • Gregoraszczuk EL, Rak-Mardyła A, Ryś J, Jakubowicz J, Urbański K. 2015. Effect of chemotherapeutic drugs on caspase-3 activity, as a key biomarker for apoptosis in ovarian tumor cell cultured as monolayer. A pilot study. Iran J Pharm Res. 14(4):1153
  • Grillone A, Riva ER, Mondini A, Forte C, Calucci L, Innocenti C, de Julian Fernandez C, Cappello V, Gemmi M, Moscato S, et al. 2015. Active targeting of sorafenib: preparation, characterization, and in vitro testing of drug‐loaded magnetic solid lipid nanoparticles. Adv Healthcare Mater. 4(11):1681–1690.
  • Gupta B, Poudel BK, Pathak S, Tak JW, Lee HH, Jeong J-H, Choi H-G, Yong CS, Kim JO. 2016. Effects of formulation variables on the particle size and drug encapsulation of imatinib-loaded solid lipid nanoparticles. AAPS PharmSciTech. 17(3):652–662.
  • Hamishehkar H, Ghanbarzadeh S, Sepehran S, Javadzadeh Y, Adib ZM, Kouhsoltani M. 2016. Histological assessment of follicular delivery of flutamide by solid lipid nanoparticles: potential tool for the treatment of androgenic alopecia. Drug Develop Industr Pharm. 42(6):846–853.
  • Hashemipour S, Panahi HA. 2017. Fabrication of magnetite nanoparticles modified with copper based metal organic framework for drug delivery system of letrozole. J Molecular Liquids. 243:102–107.
  • Helgason T, Awad TS, Kristbergsson K, McClements DJ, Weiss J. 2009. Effect of surfactant surface coverage on formation of solid lipid nanoparticles (SLN). J Colloid Interface Sci. 334(1):75–81.
  • How S-C, Chen Y-F, Hsieh P-L, Wang SSS, Jan J-S. 2017. Cell-targeted, dual reduction-and pH-responsive saccharide/lipoic acid-modified poly (L-lysine) and poly (acrylic acid) polyionic complex nanogels for drug delivery. Colloids Surfaces B: Biointerf. 153:244–252.
  • Hsu H-Y, Lin T-Y, Hu C-H, Shu DTF, Lu M-K. 2018. Fucoidan upregulates TLR4/CHOP-mediated caspase-3 and PARP activation to enhance cisplatin-induced cytotoxicity in human lung cancer cells. Cancer Lett. 432:112–120.
  • Huang Y, Mao K, Zhang B, Zhao Y. 2017. Superparamagnetic iron oxide nanoparticles conjugated with folic acid for dual target-specific drug delivery and MRI in cancer theranostics. Mater Sci Eng C. 70:763–771.
  • Jain A, Kesharwani P, Garg NK, Jain A, Jain SA, Jain AK, Nirbhavane P, Ghanghoria R, Tyagi RK, Katare OP. 2015. Galactose engineered solid lipid nanoparticles for targeted delivery of doxorubicin. Colloids Surfaces B: Biointerf. 134:47–58.
  • Jawahar N, Meyyanathan SN. 2012. Polymeric nanoparticles for drug delivery and targeting: a comprehensive review. Int J Health Allied Sci. 1(4):217.
  • Jones E, Ojewole E, Kalhapure R, Govender T. 2014. In vitro comparative evaluation of monolayered multipolymeric films embedded with didanosine-loaded solid lipid nanoparticles: a potential buccal drug delivery system for ARV therapy. Drug Develop Industr Pharm. 40(5):669–679.
  • Kabilova TO, Shmendel EV, Gladkikh DV, Chernolovskaya EL, Markov OV, Morozova NG, Maslov MA, Zenkova MA. 2018. Targeted delivery of nucleic acids into xenograft tumors mediated by novel folate-equipped liposomes. Eur J Pharm Biopharm. 123:59–70.
  • Kayacan S, Sener LT, Melikoglu G, Kultur S, Albeniz I, Ozturk M. 2018. Induction of apoptosis by Centaurea nerimaniae extract in HeLa and MDA-MB-231 cells by a caspase-3 pathway. Biotech Histochem. 93(5):311–319.
  • Khalaj Moazen M, Ahmad Panahi H. 2017. Magnetic iron oxide nanoparticles grafted N‐isopropylacrylamide/chitosan copolymer for the extraction and determination of letrozole in human biological samples. J Sep Sci. 40(5):1125–1132.
  • Khaliq NU, Park DY, Lee HJ, Oh KS, Seo JH, Kim SY, Hwang CS, Lim T-H, Yuk SH. 2018. Pluronic/Heparin Nanoparticles for Chemo-Photodynamic Combination Cancer Therapy through Photoinduced Caspase-3 Activation. ACS Appl Nano Mater. 1(6):2943–2952.
  • Khare A, Singh I, Pawar P, Grover K. 2016. Design and evaluation of voriconazole loaded solid lipid nanoparticles for ophthalmic application. J Drug Delivery. 2016:1.
  • Kumar VV, Chandrasekar D, Ramakrishna S, Kishan V, Rao YM, Diwan PV. 2007. Development and evaluation of nitrendipine loaded solid lipid nanoparticles: influence of wax and glyceride lipids on plasma pharmacokinetics. Int J Pharm. 335(1-2):167–175.
  • Kunac N, Šundov Ž, Vilović K. 2019. Apoptosis as a Prognostic Factor in Colorectal Carcinoma: comparison of TUNEL Method and Immunohistochemical Expression of Caspase-3. Appl Immunohistochem Molecular Morphol. 27(3):e22–e27.
  • Kuo Y-C, Ko H-F. 2013. Targeting delivery of saquinavir to the brain using 83-14 monoclonal antibody-grafted solid lipid nanoparticles. Biomaterials. 34(20):4818–4830.
  • Li L, Xu X, Fang L, Liu Y, Sun Y, Wang M, Zhao N, He Z. 2010. The transdermal patches for site-specific delivery of letrozole: a new option for breast cancer therapy. AAPS PharmSciTech. 11(3):1054–1057.
  • Li X, Zhen D, Lu X, Xu H, Shao Y, Xue Q, Hu Y, Liu B, Sun W. 2010. Enhanced cytotoxicity and activation of ROS-dependent c-Jun NH2-terminal kinase and caspase-3 by low doses of tetrandrine-loaded nanoparticles in Lovo cells––a possible Trojan strategy against cancer. Eur J Pharm Biopharm. 75(3):334–340.
  • Liang Y-J, Hao Q, Wu Y-Z, Wang Q-L, Wang J-D, Hu Y-L. 2009. Aromatase inhibitor letrozole in synergy with curcumin in the inhibition of xenografted endometrial carcinoma growth. Int J Gynecol Cancer. 19(7):1248–1252.
  • Liu Z, Zhao H, Shu L, Zhang Y, Okeke C, Zhang L, Li J, Li N. 2015. Preparation and evaluation of Baicalin-loaded cationic solid lipid nanoparticles conjugated with OX26 for improved delivery across the BBB. Drug Develop Industr Pharm. 41(3):353–361.
  • Manjunath K, Venkateswarlu V. 2005. Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration. J Controlled Release. 107(2):215–228.
  • Manjunath K, Venkateswarlu V. 2006. Pharmacokinetics, tissue distribution and bioavailability of nitrendipine solid lipid nanoparticles after intravenous and intraduodenal administration. J Drug Targeting. 14(9):632–645.
  • Manjunath K, Venkateswarlu V, Hussain A. 2011. Preparation and characterization of nitrendipine solid lipid nanoparticles. Die Pharmazie––An Int J Pharm Sci. 66(3):178–186.
  • McDonnell DP, Wardell SE, Norris JD. 2015. Oral selective estrogen receptor downregulators (SERDs), a breakthrough endocrine therapy for breast cancer. ACS Publications.
  • Motiei M, Kashanian S. 2017. Novel amphiphilic chitosan nanocarriers for sustained oral delivery of hydrophobic drugs. Eur J Pharm Sci. 99:285–291.
  • Müller RH, Rühl D, Runge S, Schulze-Forster K, Mehnert W. 1997. Cytotoxicity of solid lipid nanoparticles as a function of the lipid matrix and the surfactant. Pharm Res. 14(4):458–462.
  • Natarajan U, Venkatesan T, Radhakrishnan V, Samuel S, Rathinavelu A. 2018. Differential Mechanisms of Cell Death Induced by HDAC Inhibitor SAHA and MDM2 Inhibitor RG7388 in MCF-7 Cells. Cells. 8(1):8.
  • Nerella A, Basava R, Devi A. 2014. Formulation, optimization and in vitro characterization of letrozole loaded solid lipid nanoparticles. Int J Pharm Sci Drug Res. 6(3):183–188.
  • Nguyen TL, Nguyen TH, Nguyen CK, Nguyen DH. 2017. Redox and pH responsive poly (amidoamine) dendrimer-heparin conjugates via disulfide linkages for letrozole delivery. BioMed Res Int. 2017:1.
  • Ngwuluka NC, Kotak DJ, Devarajan PV. 2017. Design and characterization of metformin-loaded solid lipid nanoparticles for colon cancer. AAPS PharmSciTech. 18(2):358–368.
  • Oliveira JM, Salgado AJ, Sousa N, Mano JF, Reis RL. 2010. Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies—a review. Progress Polymer Sci. 35(9):1163–1194.
  • Patel MP, Patel RR, Patel JK. 2010. Chitosan mediated targeted drug delivery system: a review. J Pharm Pharm Sci. 13(4):536–557.
  • Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R, Langer R. 2007. Nanocarriers as an emerging platform for cancer therapy. Nature Nanotech. 2(12):751.
  • Phang C-W, Karsani SA, Malek SNA. 2017. Induction of apoptosis and cell cycle arrest by flavokawain C on HT-29 human colon adenocarcinoma via enhancement of reactive oxygen species generation, upregulation of p21, p27, and Gadd153, and inactivation of inhibitor of apoptosis proteins. Phcog Mag. 13(Suppl 2):S321.
  • Rajpoot K, Jain SK. 2018. Colorectal cancer-targeted delivery of oxaliplatin via folic acid-grafted solid lipid nanoparticles: preparation, optimization, and in vitro evaluation. Artificial cells. Nanomed Biotechnol. 46(6):1236–1247.
  • Sandri G, Motta S, Bonferoni MC, Brocca P, Rossi S, Ferrari F, Rondelli V, Cantù L, Caramella C, Del Favero E. 2017. Chitosan-coupled solid lipid nanoparticles: tuning nanostructure and mucoadhesion. Eur J Pharm Biopharm. 110:13–18.
  • Shi L-L, Lu J, Cao Y, Liu J-Y, Zhang X-X, Zhang H, Cui J-H, Cao Q-R. 2017. Gastrointestinal stability, physicochemical characterization and oral bioavailability of chitosan or its derivative-modified solid lipid nanoparticles loading docetaxel. Drug Develop Industr Pharm. 43(5):839–846.
  • Shilpi S, Vimal VD, Soni V. 2015. Assessment of lactoferrin-conjugated solid lipid nanoparticles for efficient targeting to the lung. Prog Biomater. 4(1):55–63.
  • Siddiqui A, Alayoubi A, El-Malah Y, Nazzal S. 2014. Modeling the effect of sonication parameters on size and dispersion temperature of solid lipid nanoparticles (SLNs) by response surface methodology (RSM). Pharm Develop Technol. 19(3):342–346.
  • Singh I, Swami R, Pooja D, Jeengar M.K, Khan W, Sistla R. 2016. Lactoferrin bioconjugated solid lipid nanoparticles: a new drug delivery system for potential brain targeting. J Drug Targeting. 24(3):212–223.
  • Soni N, Soni N, Pandey H, Maheshwari R, Kesharwani P, Tekade R.K. 2016. Augmented delivery of gemcitabine in lung cancer cells exploring mannose anchored solid lipid nanoparticles. J Colloid Interf Sci. 481:107–116.
  • Stewart S, Domínguez-Robles J, Donnelly R, Larrañeta E. 2018. Implantable polymeric drug delivery devices: classification, manufacture, materials, and clinical applications. Polymers. 10(12):1379.
  • Sudimack J, Lee RJ. 2000. Targeted drug delivery via the folate receptor. Adv Drug Delivery Rev. 41(2):147–162.
  • Thiantanawat A, Long BJ, Brodie AM. 2003. Signaling pathways of apoptosis activated by aromatase inhibitors and antiestrogens. Cancer Res. 63(22):8037–8050.
  • Tivnan A, Heilinger T, Ramsey JM, O'Connor G, Pokorny JL, Sarkaria JN, Stringer BW, Day BW, Boyd AW, Kim EL, et al. 2017. Anti-GD2-ch14. 18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells. Oncotarget. 8(10):16605.
  • Vassie JA, Whitelock JM, Lord MS. 2018. Targeted delivery and redox activity of folic acid-functionalized nanoceria in tumor cells. Mol Pharm. 15(3):994–1004.
  • Vieira ACC, Chaves LL, Pinheiro M, Lima SAC, Ferreira D, Sarmento B, Reis S. 2018. Mannosylated solid lipid nanoparticles for the selective delivery of rifampicin to macrophages. Artificial cells. Nanomed Biotechnol. 46(sup1):653–663.
  • Vihola H, Laukkanen A, Valtola L, Tenhu H, Hirvonen J. 2005. Cytotoxicity of thermosensitive polymers poly (N-isopropylacrylamide), poly (N-vinylcaprolactam) and amphiphilically modified poly (N-vinylcaprolactam). Biomaterials. 26(16):3055–3064.
  • Wang T, Ma X, Lei Y, Luo Y. 2016. Solid lipid nanoparticles coated with cross-linked polymeric double layer for oral delivery of curcumin. Colloids Surfaces B: Biointerf. 148:1–11.
  • Wang Y, Gao W, Shi X, Ding J, Liu W, He H, Wang K, Shao F. 2017. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature. 547(7661):99.
  • Weber S, Zimmer A, Pardeike J. 2014. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for pulmonary application: a review of the state of the art. Eur J Pharm Biopharm. 86(1):7–22.
  • Weiss J, Decker EA, McClements DJ, Kristbergsson K, Helgason T, Awad T. 2008. Solid lipid nanoparticles as delivery systems for bioactive food components. Food Biophysics. 3(2):146–154.
  • Wilczewska AZ, Niemirowicz K, Markiewicz KH, Car H. 2012. Nanoparticles as drug delivery systems. Pharmacol Rep. 64(5):1020–1037.
  • Wu Y-P, Yang J, Gao H-Y, Shen Y, Jiang L, Zhou C, Li Y-F, He R-R, Liu M. 2018. Folate-conjugated halloysite nanotubes, an efficient drug carrier, deliver doxorubicin for targeted therapy of breast cancer. ACS Appl Nano Mater. 1(2):595–608.
  • Xu Z, Shi X, Hou M, Xue P, Gao Y-E, Liu S, Kang Y. 2017. Disassembly of amphiphilic small molecular prodrug with fluorescence switch induced by pH and folic acid receptors for targeted delivery and controlled release. Colloids Surfaces B: Biointerf. 150:50–58.
  • Yadav P, Bandyopadhyay A, Chakraborty A, Sarkar K. 2018. Enhancement of anticancer activity and drug delivery of chitosan-curcumin nanoparticle via molecular docking and simulation analysis. Carbohydrate Polymers. 182:188–198.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.