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Research Articles

Sublingual tablets containing spray-dried carvedilol-loaded nanocapsules: development of an innovative nanomedicine

, , ORCID Icon, ORCID Icon & ORCID Icon
Pages 1053-1062 | Received 28 Apr 2020, Accepted 16 Jun 2020, Published online: 28 Jun 2020

References

  • Andrade DF, de Oliveira EG, Pohlmann AR, Guterres SS, Külkamp-Guerreiro IC, Beck RCR. 2018. Fluid bed granulation as an innovative process to produce dry redispersible nanocapsules: influence of cationic coating of particles. Powder Tecnol. 326:25–31.
  • Andrade DF, Vukosavljevic B, Benvenutti EV, Pohlmann AR, Guterres SS, Windbergs M, Beck R. 2018. Redispersible spray-dried lipid-core nanocapsules intended for oral delivery: the influence of the particle number on redispersibility. Pharm Dev Technol. 23(4):414–425.
  • Aodah A, Bafail RS, Rawas-Qalaji M. 2017. Formulation and evaluation of fast-disintegrating sublingual tablets of atropine sulfate: the effect of tablet dimensions and drug load on tablet characteristics. AAPS PharmSciTech. 18(5):1624–1633.
  • Beck RCR, Chaves PS, Goyanes A, Vukosavljevic B, Buanz A, Windbergs M, Basit AW, Gaisford S. 2017. 3D printed tablets loaded with polymeric nanocapsules: an innovative approach to produce customized drug delivery systems. Int J Pharm. 528(1–2):268–279.
  • Bonferoni MC, Rossi S, Ferrari F, Caramella C. 2004. Development of oral controlled-release tablet formulations based on diltiazem-carrageenan complex. Pharm Dev Technol. (2)9:155–162.
  • Chaves PS, Frank LA, Ourique AF, Pohlmann AR, Guterres SS, Beck R. 2017. Carvedilol-loaded nanocapsules: mucoadhesive properties and permeability across the sublingual mucosa. Eur J Pharm Biopharm. 114:88–95.
  • Chaves PS, Frank LA, Torge A, Schneider M, Pohlmann AR, Guterres SS, Beck R. 2019. Redispersible spray-dried powders containing carvedilol-loaded nanocapsules: mucoadhesive properties and drug permeability in sublingual mucosa. Powder Technol. 354:348–357.
  • Chaves PS, Visioli F, Buffon A, Pohlmann AR, Guterres SS, Beck R. 2019. SCC4 cell monolayers as an alternative sublingual barrier model: influence of nanoencapsulation on carvedilol transport. Drug Dev Ind Pharm. 45(1):63–66.
  • Coradini K, Lima FO, Oliveira CM, Chaves PS, Athayde ML, Carvalho LM, Beck R. 2014. Co-encapsulation of resveratrol and curcumin in lipid-core nanocapsules improves their in vitro antioxidant effects. Eur J Pharm Biopharm. 88(1):178–185.
  • Dalcin AJF, Vizzotto BS, Bochi GV, Guarda NS, Nascimento K, Sagrillo MR, Moresco RN, Schuch AP, Ourique AF, Gomes P. 2019. Nanoencapsulation of the flavonoid dihydromyricetin protects against the genotoxicity and cytotoxicity induced by cationic nanocapsules. Colloids Surf B Biointerfaces. 173:798–805.
  • Davoodi P, Lee LY, Xu Q, Sunil V, Sun Y, Soh S, Wang CH. 2018. Drug delivery systems for programmed and on-demand release. Adv Drug Deliv Rev. 132:104–138.
  • De Oliveira EG, Cardoso AM, Paese K, Coradini K, de Oliveira CV, Pohlmann AR, Oliveira MS, Guterres SS, Beck RCR. 2018. Reconstituted spray-dried phenytoin-loaded nanocapsules improve the in vivo phenytoin anticonvulsant effect and the survival time in mice. Int J Pharm. 551:121–132.
  • De Oliveira EG, De Oliveira RS, Zatta KC, Furian AF, Oliveira MS, Pohlmann AR, Guterres SS, Beck R. 2020. Phenytoin-loaded lipid-core nanocapsules improve the technological properties and in vivo performance of fluidised bed granules. Mater Sci Eng C. 111:110753.
  • El-Nahas AE, Allam AN, El-Kamel AH. 2017. Mucoadhesive buccal tablets containing silymarin Eudragit loaded nanoparticles: formulation, characterization and ex vivo permeation. J Microencapsul. 34(5):463–474.
  • Friedrich RB, Bastos MO, Fontana MC, Ourique AF, Beck R. 2010. Tablets containing drug-loaded polymeric nanocapsules: an innovative platform. J Nanosci Nanotechnol. 10(9):5885–5888.
  • Gavin A, Pham JTH, Wang D, Brownlow B, Elbayoumi TA. 2015. Layered nanoemulsions as mucoadhesive buccal systems for controlled delivery of oral cancer therapeutics. Int J Nanomed. 2015:1569–1584.
  • Hua S. 2019. Advances in nanoparticulate drug delivery approaches for sublingual and buccal administration. Front Pharmacol. 10:1328.
  • Khan A, Iqbal Z, Rehman Z, Nasir F, Khan A, Ismail M, Mohammad RA. 2014. Application of SeDeM Expert system in formulation development of effervescent tablets by direct compression. Saudi Pharm J. 22:433–444.
  • Kumar A, Naik PK, Pradhan D, Ghosh G, Rath G. 2020. Mucoadhesive formualtions: innovations, merits, drawbacks, and future outlook. Pharm Dev Technol.DOI:10.1080/10837450.2020.1753771
  • Latif R. 2013. Zero-order release profile of metoclopramide hydrochloride sublingual tablet formulation. Pharm Dev Technol. 18(6):1372–1378.
  • Morgan T. 1994. Clinical pharmacokinetics and pharmacodynamics of carvedilol. Clin Pharmacokinet. 26(5):335–346.
  • Nassar T, Rohald A, Naraykin N, Barasch D, Amsalem O, Prabhu P, Kotler M, Benita S. 2019. Nanocapsules embedded in microparticles for enhanced oral bioavailability and efficacy of Lopinavir as an anti-AIDS drug. J Drug Target. 27:590–600.
  • Patel VF, Fang L, Marc BB. 2011. Advances in oral transmucosal drug delivery. J Control Release. 153(2):106–116.
  • Pohlmann AR, Fonseca FN, Paese K, Detoni CB, Coradini K, Beck RCR, Guterres SS. 2013. Poly(ε-caprolactone) microcapsules and nanocapsules in drug delivery. Expert Opin Drug Deliv. 10(5):623–658.
  • Ribeiro RF, Motta MH, Härter APG, Flores FC, Beck RCR, Schaffazick SR, Silva CB. 2016. Spray-dried powders improve the controlled release of antifungal tioconazole-loaded polymeric nanocapsules compared to with lyophilized products. Mater Sci Eng C Mater Biol Appl. 59:875–884.
  • Rizvi SAA, Saleh AM. 2018. Applications of nanoparticle systems in drug delivery technology. Saudi Pharm J. 26(1):64–70.
  • Santos SS, Lorenzoni A, Ferreira LM, Mattiazzi J, Adams AIH, Denardi LB, Alves SH, Schaffazick SR, Cruz L. 2013. Clotrimazole-loaded Eudragit® RS100 nanocapsules: preparation, characterization and in vitro evaluation of antifungal activity against Candida species. Mater Sci Eng C Mater Biol Appl. 33(3):1389–1394.
  • Sarecka-Hujar B, Balwierz R, Ostrozka-Cieslik A, Dyja R, Lukowiec D, Jankowski A. 2017. Scanning electron microscopy and X-ray energy dispersive spectroscopy – useful tools in the analysis of pharmaceutical products. J Phys: Conf Ser. 931:012008.
  • Şenel S, Comoglu T. 2018. Orally disintegrating tablets, fast-dissolving, buccal and sublingual formulations. Pharm Dev Technol. 23(5):431.
  • Teubl BJ, Absenger M, Fröhlich E, Leitinger G, Zimmer A, Roblegg E. 2013. The oral cavity as a biological barrier system: design of an advanced buccal in vitro permeability model. Eur J Pharm Biopharm. 84(2):386–393.
  • Umerska A, Mugheirbi NA, Kasprzak A, Saulnier P, Tajber L. 2020. Carbohydrate-based Trojan microparticles as carriers for pulmonary delivery of lipid nanocapsules using dry powder inhalation. Powder Technol. 364:507–521.
  • Zuglianello C, Fontana De Andrade D, dos Santos Chaves P, Almeida Rigo L, Pohlmann AR, Guterres SS, Beck RCR. 2018. Development of redispersible spray-dried lipid-core nanocapsules and incorporation into hydrogels: PVP and lactose mixture as the drying adjuvant. Soft Mater. 16(1):20–30.

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