173
Views
10
CrossRef citations to date
0
Altmetric
Research Articles

Optimized piperine–phospholipid complex with enhanced bioavailability and hepatoprotective activity

, , , , &
Pages 69-80 | Received 07 May 2020, Accepted 07 Oct 2020, Published online: 19 Oct 2020

References

  • Allam AN, Komeil IA, Fouda MA, Abdallah OY. 2015. Preparation, characterization and in vivo evaluation of curcumin self-nano phospholipid dispersion as an approach to enhance oral bioavailability. Int J Pharm. 489:117–123.
  • Bang JS, Oh DH, Choi HM, Sur BJ, Lim SJ, Kim JY, Hi Y, Yoo MC, Hahm DH, Kim KS. 2009. Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models. Arthritis Res Ther. 11:1–9.
  • Beers RF, Seizer IW. 1952. A spectrophotometric method for measuring breakdown of hydrogen peroxide by catalase. J Biol Chem. 115:130–140.
  • Bhalekar MR, Madgulkar AR, Desale PS, Marium G. 2017. Formulation of piperine solid lipid nanoparticles (SLN) for treatment of rheumatoid arthritis. Drug Dev Ind Pharm. 43:1003–1010.
  • Bhattacharyya S, Ahmmed SM, Saha BP, Mukherjee PK. 2014. Soya phospholipid complex of mangiferin enhances its hepatoprotectivity by improving its bioavailability and pharmacokinetics. J Sci Food Agric. 94:1380–1388.
  • Boddupalli BM, Ramani R, Subramaniam B, Anisetti RN. 2012. In vitro and in vivo evaluation of hepato protection and anti-ulcer activities of piperine gastro retentive micropspheres. Asian Pac J Trop Biomed. 2:S1237–S1240.
  • CDER (Center for Drug Evaluation and Research). 2001. Guidance for industry, bioanalytical method validation. USFDA.
  • Chi C. Zhang C. Liu Y. Nie H. Zhou J. Ding Y. 2020. Phytosome nanosuspensions for silybin-phospholipid complex with increased bioavailability and hepatoprotection efficacy. Eur J Pharm Sci. 144: 1–12.
  • Dubler RE, Anderson BM. 1981. Simultaneous inactivation of the catalytic activities of yeast glutathione reductase by N-alkylmaleimides. Biochim Biophys Acta. 659:70–85.
  • Ellman GL. 1959. Tissue sulfhydryl groups. Arch Biochem Biophys. 82:70–77.
  • Elnaggar YS, Etman SM, Abdelmonsif DA, Abdallah OY. 2015a. Novel piperine-loaded Tween-integrated monoolein cubosomes as brain-targeted oral nanomedicine in Alzheimer’s disease: pharmaceutical, biological, and toxicological studies. Int J Nanomed. 10:5459–5473.
  • Elnaggar YSR, Etman S, Abdelmonsif DA, Abdallah OY. 2015b. Intranasal piperine-loaded chitosan nanoparticles as brain-targeted therapy in Alzheimer’s Disease: optimization, biological efficacy, and potential toxicity. J Pharm Sci. 104:3544–3556.
  • Ferreira SL, Bruns RE, Ferreira HS, Matos GD, David JM, Brandão GC, da Silva EG, Portugal LA, dos Reis PS, Souza AS, et al. 2007. Box-Behnken design: an alternative for the optimization of analytical methods. Anal Chim Acta. 597:179–186.
  • Fricker G, Kromp T, Wendel A, Blume A, Zirkel J, Rebmann H, Setzer C, Quinkert RO, Martin F, Müller-Goymann C. 2010. Phospholipids and lipid-based formulations in oral drug delivery. Pharm Res. 27:1469–1486.
  • Gnananath K, Nataraj KS, Battu GR. 2017. Phospholipid complex technique for superior bioavailability of phytoconstituents. Adv Pharm Bull. 7:35–42.
  • Gorgani L, Mohammadi M, Najafpour GD, Nikzad M. 2017. Piperine – the bioactive compound of black pepper: from isolation to medicinal formulations. Compr Rev Food Sci Food Saf. 16:124–140.
  • Griffin S, Wyllie SG, Markham J. 1999. Determination of octanol-water partition coefficient for terpenoids using reversed-phase high-performance liquid chromatography. J Chromatogr A. 864:221–228.
  • Habig WH, Pabst MJ, Jakoby WB. 1974. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem. 249:7130–7139.
  • Hou Z, Li Y, Huang Y, Zhou C, Lin J, Wang Y, Cui F, Zhou S, Jia M, Ye S, et al. 2013. Phytosomes loaded with mitomycin c-soybean phosphatidylcholine complex developed for drug delivery. Mol Pharm. 10:90–101.
  • ICH. 2005a. Harmonised tripartite guideline. Validation of analytical procedures: text and methodology Q2 (R1).
  • ICH. 2005b. Harmonised tripartite guideline, stability testing of new drug substances and products, Q1A (R2).
  • Kakkar B, Das PN, Viswanathan A. 1984. Modified spectrophotometer assay of SOD. Indian J Biochem Biophys. 21:130–132.
  • Khan J, Alexander A, Ajazuddin Saraf S, Saraf S. 2013. Recent advances and future prospects of phyto-phospholipid complexation technique for improving pharmacokineticprofile of plant actives. J Controlled Release. 168:50–60.
  • Khan KA. 1975. The concept of dissolution efficiency. J Pharm Pharmacol. 27:48–49.
  • Kind PRN, King EJ. 1954. Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine. J Clin Pathol. 7:322–326.
  • Koul IB, Kapil A. 1993. Evaluation of the liver protective potential of piperine, an active principle of black and long peppers. Planta Med. 59:413–417.
  • Lai LH, Fu QH, Liu Y, Jiang K, Guo QM, Chen QY, Yan B, Wang QQ, Shen JG. 2012. Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model. Acta Pharmacol Sin. 33:523–530.
  • Li C, Wang Q, Ren T, Zhang Y, Lam CWK, Chow MSS, Zuo Z. 2016. Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats. J Pharm Biomed Anal. 128:286–293.
  • Li S, Wang C, Li W, Koike K, Nikaido T, Wang MW. 2007. Antidepressant-like effects of piperine and its derivative, antiepilepsirine. J Asian Nat Prod Res. 9:421–430.
  • Lowry O, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem. 193:265–275.
  • Lu M, Qiu Q, Luo X, Liu X, Sun J, Wang C, Lin X, Deng Y, Song Y. 2018. Phyto-phospholipid complexes (phytosomes): a novel strategy to improve the bioavailability of active constituents. Asian J Pharm Sci. 14:265–274.
  • Maiti K, Mukherjee K, Murugan V, Saha BP, Mukherjee PK. 2010. Enhancing bioavailability and hepatoprotective activity of andrographolide from Andrographis paniculata a well-known medicinal food, through its herbosome. J Sci Food Agric. 90:43–51.
  • Malloy HT, Evelyn KA. 1937. The determination of bilirubin with the photoelectric colorimeter. J Biol Chem. 119:481–490.
  • Mohammadi M, Najafi H, Yarijani ZM, Vaezi G, Hojati V. 2019. Piperine pretreatment attenuates renal ischemia-reperfusion induced liver injury. Heliyon. 5:e02180.
  • Ohkawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxide for animal tissue by thiobarbituric acid reaction. Anal Biochem. 95:351–358.
  • Pachauri M, Gupta ED, Ghosh PC. 2015. Piperine loaded PEG-PLGA nanoparticles: Preparation, characterization and targeted delivery for adjuvant breast cancer chemotherapy. J Drug Delivery Sci Technol. 29:269–282.
  • Paglia DE, Valentine WN. 1967. Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase. Transl Res. 70:158–169.
  • Pathan RA, Bhandari U. 2011. Gymnemic acid-phospholipid complex: preparation and characterization. J Dispersion Sci Technol. 32:1165–1172.
  • Peng Q, Zhang Z, Sun X, Zuo J, Zhao D, Gong T. 2010. Mechanisms of phospholipid complex loaded nanoparticles enhancing the oral bioavailability. Mol Pharm. 7:565–575.
  • Rathnawathie M, Buckle KA. 1983. Determination of piperine in pepper (Piper nigrum) using high-performance liquid chromatography. J Chromatogr A. 264:316–320.
  • Reitman S, Frankel SA. 1957. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol. 28:56–63.
  • Ren T, Hu M, Cheng Y, Shek TL, Xiao M, Ho NJ, Zhang C, Leung SSY, Zuo Z. 2019. Piperine-loaded nanoparticles with enhanced dissolution and oral bioavailability for epilepsy control. Eur J Pharm Sci. 137:104988.
  • Sabina EP, Souriyan ADH, Jackline D, Rasool MK. 2010. Piperine, an active ingredient of black pepper attenuates acetaminophen-induced hepatotoxicity in mice. Asian Pac J Trop Med. 3:971–976.
  • Savic-Gajic IM, Savic IM, Nikolic VD. 2018. Modelling and optimization of quercetin extraction and biological activity of quercetin-rich red onion skin extract from Southeastern Serbia. J Food Nutr Res. 57:15–26.
  • Savic-Gajic I, Savic I, Boskov I, Žeraji ´S, Markovic I, Gajic D. 2019. Optimization of ultrasound-assisted extraction of phenolic compounds from black locust (Robiniae pseudoacaciae) flowers and comparison with conventional methods. Antioxidants. 8:214–248.
  • Savic IM, Nikolic IL, Savic-Gajic IM, Kundakovic TD. 2018. Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L). Sep Sci Technol. 54:837–846.
  • Shao B, Cui C, Ji H, Tang J, Wang Z, Liu H, Qin M, Li X, Wu L. 2015. Enhanced oral bioavailability of piperine by self-emulsifying drug delivery systems: in vitro, in vivo and in situ intestinal permeability studies. Drug Deliv. 22:740–747.
  • Sunila ES, Kuttan G. 2004. Immunomodulatory and antitumor activity of Piper longum Linn. and piperine. J Ethnopharmacol. 90:339–346.
  • Vijesh AM, Isloor AM, Telkar S, Arulmoli T, Fun HK. 2013. Molecular docking studies of some new imidazole derivatives for antimicrobial properties. Arabian J Chem. 6:197–204.
  • Yanyu X, Yunmei S, Zhipeng C, Qineng P. 2006. The preparation of silybin-phospholipid complex and the study on its pharmacokinetics in rats. Int J Pharm. 307:77–82.
  • Zafar F, Jahan N, Rahman KU, Bhatti HN. 2019. Increased oral bioavailability of piperine from an optimized Piper nigrum nanosuspension. Planta Med. 85:249–257.
  • Zhao X, Liu J, Hu Y, Fan Y, Wang D, Yuan J, Xu L, Cui L, Jing Z. 2012. Optimization on condition of glycyrrhetinic acid liposome by RSM and the research of its immunological activity. Int J Biol Macromol. 51:299–304.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.