Simvastatin nanosuspensions prepared using a combination of pH-sensitive and timed-release approaches for potential treatment of colorectal cancer

References

• Akhgari A, Sadeghi F, Garekani HA. 2006. Combination of time-dependent and pH-dependent polymethacrylates as a single coating formulation for colonic delivery of indomethacin pellets. Int J Pharm. 320(1–2):137–142.
   PubMed Web of Science ®Google Scholar
• Alomrani A, Badran M, Harisa GI, ALshehry M, Alhariri M, Alshamsan A, Alkholief M. 2019. The use of chitosan-coated flexible liposomes as a remarkable carrier to enhance the antitumor efficacy of 5-fluorouracil against colorectal cancer. Saudi Pharm J. 27(5):603–611.
   PubMed Web of Science ®Google Scholar
• Alvarez-Fuentes J, Fernández-Arévalo M, Gonzalez-Rodriguez ML, Cirri M, Mura P. 2004. Development of enteric-coated timed-release matrix tablets for colon targeting. J Drug Target. 12(9–10):607–612.
   PubMed Web of Science ®Google Scholar
• Asghar LF, Chandran S. 2006. Multiparticulate formulation approach to colon specific drug delivery: current perspectives. J Pharm Pharm Sci. 9(3):327–338.
   PubMed Web of Science ®Google Scholar
• Cho E, Cho W, Cha KH, Park J, Kim MS, Kim JS, Park HJ, Hwang SJ. 2010. Enhanced dissolution of megestrol acetate microcrystals prepared by antisolvent precipitation process using hydrophilic additives. Int J Pharm. 396(1–2):91–98.
   PubMed Web of Science ®Google Scholar
• Dalvi SV, Dave RN. 2009. Controlling particle size of a poorly water-soluble drug using ultrasound and stabilizers in antisolvent precipitation. Ind Eng Chem Res. 48(16):7581–7593.
   Web of Science ®Google Scholar
• Elbary AA, Ibrahim HK, Hazaa BS. 2011. Formulation and evaluation of colon targeted tablets containing simvastatin solid dispersion. Drugs and Therapy Studies. 1(1):e16.
   Google Scholar
• Feng FF, Zhang DR, Tian KL, Lou HY, Qi XL, Wang YC, Duan CX, Jia LJ, Wang FH, Liu Y, et al. 2011. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by oridonin nanosuspension. Drug Deliv. 18(4):265–271.
   PubMed Web of Science ®Google Scholar
• Gao Y, Li Z, Sun M, Guo C, Yu A, Xi Y, Cui J, Lou H, Zhai G. 2011. Preparation and characterization of intravenously injectable curcumin nanosuspension. Drug Deliv. 18(2):131–142.
   PubMed Web of Science ®Google Scholar
• Grifantini R, Taranta M, Gherardini L, Naldi I, Parri M, Grandi A, Giannetti A, Tombelli S, Lucarini G, Ricotti L, et al. 2018. Magnetically driven drug delivery systems improving targeted immunotherapy for colon-rectal cancer. J Control Release. 280:76–86.
   PubMed Web of Science ®Google Scholar
• Guo L, Kang L, Liu X, Lin X, Di D, Wu Y, Kong D, Deng Y, Song Y. 2017. A novel nanosuspension of andrographolide: preparation, characterization and passive liver target evaluation in rats. Eur J Pharm Sci. 104:13–22.
   PubMed Web of Science ®Google Scholar
• Homayouni A, Sadeghi F, Varshosaz J, Garekani HA, Nokhodchi A. 2014. Promising dissolution enhancement effect of soluplus on crystallized celecoxib obtained through antisolvent precipitation and high pressure homogenization techniques. Colloids Surf B Biointerfaces. 122:591–600.
   PubMed Web of Science ®Google Scholar
• Hong C, Dang Y, Lin G, Yao Y, Li G, Ji G, Shen H, Xie Y. 2014. Effects of stabilizing agents on the development of myricetin nanosuspension and its characterization: an in vitro and in vivo evaluation. Int J Pharm. 477(1–2):251–260.
   PubMed Web of Science ®Google Scholar
• Hou CD, Wang JX, Le Y, Zou HK, Zhao H. 2012. Preparation of azithromycin nanosuspensions by reactive precipitation method. Drug Dev Ind Pharm. 38(7):848–854.
   PubMed Web of Science ®Google Scholar
• Huang Y, Luo X, You X, Xia Y, Song X, Yu L. 2013. The preparation and evaluation of water-soluble SKLB610 nanosuspensions with improved bioavailability. AAPS PharmSciTech. 14(3):1236–1243.
   PubMed Web of Science ®Google Scholar
• Jang HJ, Hong EM, Jang J, Choi JE, Park SW, Byun HW, Koh DH, Choi MH, Kae SH, Lee J. 2016. Synergistic effects of simvastatin and irinotecan against colon cancer cells with or without irinotecan resistance. Gastroenterol Res Pract. 2016:7891374
   PubMed Web of Science ®Google Scholar
• Jiang T, Han N, Zhao B, Xie Y, Wang S. 2012. Enhanced dissolution rate and oral bioavailability of simvastatin nanocrystal prepared by sonoprecipitation. Drug Dev Ind Pharm. 38(10):1230–1239.
   PubMed Web of Science ®Google Scholar
• Jung HJ, Ahn HI, Park JY, Ho MJ, Lee DR, Cho HR, Park JS, Choi YS, Kang MJ. 2016. Improved oral absorption of tacrolimus by a solid dispersion with hypromellose and sodium lauryl sulfate. Int J Biol Macromol. 83:282–287.
   PubMed Web of Science ®Google Scholar
• Keck CM, Müller RH. 2006. Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation. Eur J Pharm Biopharm. 62(1):3–16.
   PubMed Web of Science ®Google Scholar
• Kwon HY, Lee JY, Choi SW, Jang Y, Kim JH. 2001. Preparation of PLGA nanoparticles containing estrogen by emulsification–diffusion method. Colloids and Surf A: Physicochem Eng Asp. 182(1–3):123–130.
   Web of Science ®Google Scholar
• Laitinen R, Löbmann K, Grohganz H, Strachan C, Rades T. 2014. Amino acids as co-amorphous excipients for simvastatin and glibenclamide: physical properties and stability. Mol Pharm. 11(7):2381–2389.
   PubMed Web of Science ®Google Scholar
• Li N, Xie X, Hu Y, He H, Fu X, Fang T, Li C. 2019. Herceptin-conjugated liposomes co-loaded with doxorubicin and simvastatin in targeted prostate cancer therapy. Am J Transl Res. 11(3):1255–1269.
   PubMed Web of Science ®Google Scholar
• Liu D, Xu H, Tian B, Yuan K, Pan H, Ma S, Yang X, Pan W. 2012. Fabrication of carvedilol nanosuspensions through the anti-solvent precipitation-ultrasonication method for the improvement of dissolution rate and oral bioavailability. AAPS Pharmscitech. 13(1):295–304.
   PubMed Web of Science ®Google Scholar
• Löbmann K, Strachan C, Grohganz H, Rades T, Korhonen O, Laitinen R. 2012. Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactions. Eur J Pharm Biopharm. 81(1):159–169.
   PubMed Web of Science ®Google Scholar
• Luput L, Licarete E, Drotar DM, Nagy A-L, Sesarman A, Patras L, Rauca VF, Porfire A, Muntean D, Achim M, et al. 2018. In vivo double targeting of C26 colon carcinoma cells and microenvironmental protumor processes using liposomal simvastatin. J Cancer. 9(2):440–449.
   PubMed Web of Science ®Google Scholar
• Mahesh KV, Singh SK, Gulati M. 2014. A comparative study of top-down and bottom-up approaches for the preparation of nanosuspensions of glipizide. Powder Technol. 256:436–449.
   Web of Science ®Google Scholar
• Mao S, Shi Y, Li L, Xu J, Schaper A, Kissel T. 2008. Effects of process and formulation parameters on characteristics and internal morphology of poly(d,l-lactide-co-glycolide) microspheres formed by the solvent evaporation method. Eur J Pharm Biopharm. 68(2):214–223.
   PubMed Web of Science ®Google Scholar
• Matusewicz L, Filip-Psurska B, Psurski M, Tabaczar S, Podkalicka J, Wietrzyk J, Ziółkowski P, Czogalla A, Sikorski AF. 2019. EGFR-targeted immunoliposomes as a selective delivery system of simvastatin, with potential use in treatment of triple-negative breast cancers. Int J Pharm. 569:118605.
   PubMed Web of Science ®Google Scholar
• Mishra B, Sahoo J, Dixit PK. 2015. Formulation and process optimization of naproxen nanosuspensions stabilized by hydroxy propyl methyl cellulose. Carbohydr Polym. 127:300–308.
   PubMed Web of Science ®Google Scholar
• Müller RH, Jacobs C, Kayser O. 2001. Nanosuspensions as particulate drug formulations in therapy. Rationale for development and what we can expect for the future. Adv Drug Deliv Rev. 47(1):3–19.
   PubMed Web of Science ®Google Scholar
• Naeem M, Choi M, Cao J, Lee Y, Ikram M, Yoon S, Lee J, Moon HR, Kim MS, Jung Y, et al. 2015. Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy. Drug Des Devel Ther. 9:3789–3799.
   PubMed Web of Science ®Google Scholar
• Pan Q, Xu J, Ma L. 2020. Simvastatin enhances chemotherapy in cervical cancer via inhibition of multiple prenylation‐dependent GTP ases‐regulated pathways. Fundam Clin Pharmacol. 34(1):32–40.
   PubMed Web of Science ®Google Scholar
• Pandey S, Mattha Vijayendra Swamy S, Mansha Ubaid Ulla U, Gupta A, Patel H, Singh Yadav J. 2017. Cell line and augument cellular uptake study of statistically optimized sustained release capecitabine loaded Eudragit S100/PLGA (poly (lacticco-glycolic acid)) nanoparticles for colon targeting. Curr Drug Deliv. 14(6):887–899.
   PubMed Web of Science ®Google Scholar
• Pandey S, Swamy SV, Gupta A, Koli A, Patel S, Maulvi F, Vyas B. 2018. Multiple response optimisation of processing and formulation parameters of pH sensitive sustained release pellets of capecitabine for targeting colon. J Microencapsul. 35(3):259–271.
   PubMed Web of Science ®Google Scholar
• Pardeike J, Müller RH. 2010. Nanosuspensions: a promising formulation for the new phospholipase A2 inhibitor PX-18. Int J Pharm. 391(1–2):322–329.
   PubMed Web of Science ®Google Scholar
• Patel MM, Amin AF. 2011. Formulation and development of release modulated colon targeted system of meloxicam for potential application in the prophylaxis of colorectal cancer. Drug Deliv. 18(4):281–293.
   PubMed Web of Science ®Google Scholar
• Patel MM, Shah TJ, Amin AF, Shah NN. 2009. Design, development and optimization of a novel time and pH-dependent colon targeted drug delivery system. Pharm Dev Tech. 14(1):65–72.
   Web of Science ®Google Scholar
• Porfire A, Tomuta I, Muntean D, Luca L, Licarete E, Alupei MC, Achim M, Vlase L, Banciu M. 2015. Optimizing long-circulating liposomes for delivery of simvastatin to C26 colon carcinoma cells. J Liposome Res. 25(4):261–269.
   PubMed Web of Science ®Google Scholar
• Qiao H, Chen L, Rui T, Wang J, Chen T, Fu T, Li J, Di L. 2017. Fabrication and in vitro/in vivo evaluation of amorphous andrographolide nanosuspensions stabilized by d-α-tocopheryl polyethylene glycol 1000 succinate/sodium lauryl sulfate. IJN. 12:1033–1046.
   Web of Science ®Google Scholar
• Sharma A, Kim EJ, Shi H, Lee JY, Chung BG, Kim JS. 2018. Development of a theranostic prodrug for colon cancer therapy by combining ligand-targeted delivery and enzyme-stimulated activation. Biomaterials. 155:145–151.
   PubMed Web of Science ®Google Scholar
• Sharma N, Madan P, Lin S. 2016a. Effect of process and formulation variables on the preparation of parenteral paclitaxel-loaded biodegradable polymeric nanoparticles: a co-surfactant study. Asian J Pharm Sci. 11(3):404–416.
   Web of Science ®Google Scholar
• Sharma OP, Patel V, Mehta T. 2016b. Design of experiment approach in development of febuxostat nanocrystal: application of soluplus as stabilizer. Powder Technol. 302:396–405.
   Web of Science ®Google Scholar
• Varshosaz J, Minayian M, Yazdekhasti S. 2017. Physicochemical, pharmacodynamic and pharmacokinetic characterization of Soluplus stabilized nanosuspension of tacrolimus. Curr Drug Deliv. 14(4):521–535.
   PubMed Web of Science ®Google Scholar
• Yadav D, Kumar N. 2014. Nanonization of curcumin by antisolvent precipitation: process development, characterization, freeze drying and stability performance. Int J Pharm. 477(1–2):564–577.
   PubMed Web of Science ®Google Scholar
• Yang H, Teng F, Wang P, Tian B, Lin X, Hu X, Zhang L, Zhang K, Zhang Y, Tang X. 2014. Investigation of a nanosuspension stabilized by Soluplus® to improve bioavailability. Int J Pharm. 477(1–2):88–95.
   PubMed Web of Science ®Google Scholar
• Zhang ZB, Shen ZG, Wang JX, Zhao H, Chen JF, Yun J. 2009. Nanonization of megestrol acetate by liquid precipitation. Ind Eng Chem Res. 48(18):8493–8499.
   Web of Science ®Google Scholar
• Zheng D, Wang Y, Zhang D, Liu Z, Duan C, Jia L, Wang F, Liu Y, Liu G, Hao L, et al. 2011. In vitro antitumor activity of silybin nanosuspension in PC-3 cells. Cancer Lett. 307(2):158–164.
   PubMed Web of Science ®Google Scholar