174
Views
0
CrossRef citations to date
0
Altmetric
Research Articles

Preparation and characterization of a hydroxypropyl methylcellulose based wafer for simultaneous delivery of phenytoin and insulin as wound dressing material

, , , &
Pages 301-312 | Received 01 Sep 2021, Accepted 01 Mar 2022, Published online: 16 Mar 2022

References

  • Abdelkader DH, Tambuwala MM, Mitchell CA, Osman MA, El-Gizawy SA, Faheem AM, El-Tanani M, McCarron PA. 2018. Enhanced cutaneous wound healing in rats following topical delivery of insulin-loaded nanoparticles embedded in poly(vinyl alcohol)-borate hydrogels. Drug Deliv Transl Res. 8(5):1053–1065.
  • Abderrahim LA, Taïbi K, Abderrahim NA, Boussaid M, Rios-Navarro C, Ruiz-Saurí A. 2019. Euphorbia honey and garlic: biological activity and burn wound recovery. Burns. 45(7):1695–1706.
  • Abruzzo A, Nicoletta FP, Dalena F, Cerchiara T, Luppi B, Bigucci F. 2017. Bilayered buccal films as child-appropriate dosage form for systemic administration of propranolol. Int J Pharm. 531(1):257–265.
  • Agel MR, Baghdan E, Pinnapireddy SR, Lehmann J, Schäfer J, Bakowsky U. 2019. Curcumin loaded nanoparticles as efficient photoactive formulations against gram-positive and gram-negative bacteria. Colloids Surf B Biointerfaces. 178:460–468.
  • Ai X, Zhong L, Niu H, He Z. 2014. Thin-film hydration preparation method and stability test of DOX-loaded disulfide-linked polyethylene glycol 5000-lysine-di-tocopherol succinate nanomicelles. Asian J Pharm Sci. 9(5):244–250.
  • Aliabadi HM, Lavasanifar A. 2006. Polymeric micelles for drug delivery. Expert Opin Drug Deliv. 3(1):139–162.
  • Alves A, Miguel SP, Araujo AR, de Jesús Valle MJ, Sánchez Navarro A, Correia IJ, Ribeiro MP, Coutinho P. 2020. Xanthan gum–Konjac glucomannan blend hydrogel for wound healing. Polymers. 12(1):99.
  • Amanat S, Taymouri S, Varshosaz J, Minaiyan M, Talebi A. 2020. Carboxymethyl cellulose-based wafer enriched with resveratrol-loaded nanoparticles for enhanced wound healing. Drug Deliv Transl Res. 10(5):1241–1254.
  • Atef E, Belmonte AA. 2008. Formulation and in vitro and in vivo characterization of a phenytoin self-emulsifying drug delivery system (SEDDS). Eur J Pharm Sci. 35(4):257–263.
  • Atia NM, Hazzah HA, Gaafar PM, Abdallah OY. 2019. Diosmin nanocrystal-loaded wafers for treatment of diabetic ulcer: in vitro and in vivo evaluation. J Pharm Sci. 108(5):1857–1871.
  • Ayensu I, Mitchell JC, Boateng JS. 2012. Development and physico-mechanical characterisation of lyophilised chitosan wafers as potential protein drug delivery systems via the buccal mucosa. Colloids Surf B Biointerfaces. 91:258–265.
  • Bianchi SE, Machado BEK, da Silva MGC, da Silva MMA, Bosco LD, Marques MS, Horn AP, Persich L, Geller FC, Argenta D, et al. 2018. Coumestrol/hydroxypropyl-β-cyclodextrin association incorporated in hydroxypropyl methylcellulose hydrogel exhibits wound healing effect: in vitro and in vivo study. Eur J Pharm Sci. 119:179–188.
  • Bigucci F, Abruzzo A, Saladini B, Gallucci MC, Cerchiara T, Luppi B. 2015. Development and characterization of chitosan/hyaluronan film for transdermal delivery of thiocolchicoside. Carbohydr Polym. 130:32–40.
  • Bonde GV, Ajmal G, Yadav SK, Mittal P, Singh J, Bakde BV, Mishra B. 2020. Assessing the viability of Soluplus® self-assembled nanocolloids for sustained delivery of highly hydrophobic lapatinib (anticancer agent): optimisation and in-vitro characterisation. Colloids Surf B Biointerfaces. 185:110611.
  • Cardoso AM, de Oliveira EG, Coradini K, Bruinsmann FA, Aguirre T, Lorenzoni R, Barcelos RCS, Roversi K, Rossato DR, Pohlmann AR, et al. 2019. Chitosan hydrogels containing nanoencapsulated phenytoin for cutaneous use: skin permeation/penetration and efficacy in wound healing. Mater Sci Eng C Mater Biol Appl. 96:205–217.
  • Chen MC, Tsai HW, Liu CT, Peng SF, Lai WY, Chen SJ, Chang Y, Sung HW. 2009. A nanoscale drug-entrapment strategy for hydrogel-based systems for the delivery of poorly soluble drugs. Biomaterials. 30(11):2102–2111.
  • Ci M, Liu J, Shang S, Jiang Z, Zhu P, Sui S. 2020. The effect of HPMC and CNC on the structure and properties of alginate fibers. Fibers Polym. 21(10):2179–2185.
  • Ehterami A, Salehi M, Farzamfar S, Vaez A, Samadian H, Sahrapeyma H, Mirzaii M, Ghorbani S, Goodarzi A. 2018. In vitro and in vivo study of PCL/COLL wound dressing loaded with insulin-chitosan nanoparticles on cutaneous wound healing in rats model. Int J Biol Macromol. 117:601–609.
  • Freag MS, Saleh WM, Abdallah OY. 2018. Exploiting polymer blending approach for fabrication of buccal chitosan-based composite sponges with augmented mucoadhesive characteristics. Eur J Pharm Sci. 120:10–19.
  • Gainza G, Villullas S, Pedraz JL, Hernandez RM, Igartua M. 2015. Advances in drug delivery systems (DDSs) to release growth factors for wound healing and skin regeneration. Nanomedicine. 11(6):1551–1573.
  • Hasamnis AA, Mohanty BK, Patil S. 2010. Evaluation of wound healing effect of topical phenytoin on excisional wound in albino rats. J Young Pharm. 2(1):59–62.
  • Ju C, Sun J, Zi P, Jin X, Zhang C. 2013. Thermosensitive micelles-hydrogel hybrid system based on poloxamer 407 for localized delivery of paclitaxel. J Pharm Sci. 102(8):2707–2717.
  • Kondaveeti S, Damato TC, Carmona-Ribeiro AM, Sierakowski MR, Petri DF. 2017. Sustainable hydroxypropyl methylcellulose/xyloglucan/gentamicin films with antimicrobial properties. Carbohydr Polym. 165:285–293.
  • Lee WK, Park JY, Yang EH, Suh H, Kim SH, Chung DS, Choi K, Yang CW, Park JS. 2002. Investigation of the factors influencing the release rates of cyclosporin A-loaded micro- and nanoparticles prepared by high-pressure homogenizer. J Control Release. 84(3):115–123.
  • Mohamed EA, Hashim II, Yusif RM, Suddek GM, Shaaban AA, Badria FA. 2017. Enhanced in vitro cytotoxicity and anti-tumor activity of vorinostat-loaded pluronic micelles with prolonged release and reduced hepatic and renal toxicities. Eur. J. Pharm. Sci. 96:232–242.
  • Motawea A, Abd El AE, Borg T, Motawea M, Tarshoby M. 2019. The impact of topical phenytoin loaded nanostructured lipid carriers in diabetic foot ulceration. Foot (Edinb)). 40:14–21.
  • Neuvonen PJ. 1979. Bioavailability of phenytoin: clinical pharmacokinetic and therapeutic implications. Clin Pharmacokinet. 4(2):91–103.
  • Pachuau L. 2015. Recent developments in novel drug delivery systems for wound healing. Expert Opin Drug Deliv. 12(12):1895–1909.
  • Phaechamud T, Issarayungyuen P, Pichayakorn W. 2016. Gentamicin sulfate-loaded porous natural rubber films for wound dressing. Int J Biol Macromol. 85:634–644.
  • Pleguezuelos-Villa M, Nácher A, Hernández MJ, Busó MO, Barrachina M, Peñalver N, Díez-Sales O. 2019. A novel lidocaine hydrochloride mucoadhesive films for periodontal diseases. J Mater Sci Mater Med. 30(1):14.
  • Rahman Z, Dharani S, Ali SF, Afrooz H, Reddy IK, Khan MA. 2018. Effect of processing parameters and controlled environment storage on the disproportionation and dissolution of extended-release capsule of phenytoin sodium. Int J Pharm. 550(1–2):290–299.
  • Rezvanian M, Tan CK, Ng SF. 2016. Simvastatin-loaded lyophilized wafers as a potential dressing for chronic wounds. Drug Dev Ind Pharm. 42(12):2055–2062.
  • Saadat E, Amini M, Khoshayand MR, Dinarvand R, Dorkoosh FA. 2014. Synthesis and optimization of a novel polymeric micelle based on hyaluronic acid and phospholipids for delivery of paclitaxel, in vitro and in-vivo evaluation. Int J Pharm. 475(1–2):163–173.
  • Saddik MS, Alsharif FM, El-Mokhtar MA, Al-Hakkani MF, El-Mahdy MM, Farghaly HS, Abou-Taleb HA. 2020. Biosynthesis, characterization, and wound-healing activity of phenytoin-loaded copper nanoparticles. AAPS PharmSciTech. 21(5):175.
  • Sanad RA, Abdel-Bar HM. 2017. Chitosan-hyaluronic acid composite sponge scaffold enriched with Andrographolide-loaded lipid nanoparticles for enhanced wound healing. Carbohydr Polym. 173:441–450.
  • Severino P, Andreani T, Jäger A, Chaud MV, Santana MH, Silva AM, Souto EB. 2014. Solid lipid nanoparticles for hydrophilic biotech drugs: optimization and cell viability studies (Caco-2 & HEPG-2 cell lines). Eur J Med Chem. 81:28–34.
  • Sharma N, Madan P, Lin S. 2016. Effect of process and formulation variables on the preparation of parenteral paclitaxel-loaded biodegradable polymeric nanoparticles: a co-surfactant study. Asian J. Pharm. 11(3):404–416.
  • Sheu MT, Jhan HJ, Su CY, Chen LC, Chang CE, Liu DZ, Ho HO. 2016. Codelivery of doxorubicin-containing thermosensitive hydrogels incorporated with docetaxel-loaded mixed micelles enhances local cancer therapy. Colloids Surf B Biointerfaces. 143:260–270.
  • Taymouri S, Ahmadi Z, Mirian M, Tavakoli N. 2021. Simvastatin nanosuspensions prepared using a combination of pH-sensitive and timed-release approaches for potential treatment of colorectal cancer. Pharm Dev Technol. 26(3):335–348.
  • Teo SY, Yew MY, Lee SY, Rathbone MJ, Gan SN, Coombes AG. 2017. In vitro evaluation of novel phenytoin-loaded alkyd nanoemulsions designed for application in topical wound healing. J Pharm Sci. 106(1):377–384.
  • Varshosaz J, Taymouri S, Hassanzadeh F, Javanmard SH, Rostami M. 2015. Self-assembly micelles with lipid core of cholesterol for docetaxel delivery to B16F10 melanoma and HepG2 cells. J Liposome Res. 25(2):157–165.
  • Vijayan V, Reddy KR, Sakthivel S, Swetha C. 2013. Optimization and charaterization of repaglinide biodegradable polymeric nanoparticle loaded transdermal patchs: in vitro and in vivo studies. Colloids Surf B Biointerfaces. 111:150–155.
  • Wang J, Xu J. 2020. Effects of topical insulin on wound healing: a review of animal and human evidences. Diabetes Metab Syndr Obes. 13:719–727.
  • Yan S, Ren J, Jian Y, Wang W, Yun W, Yin J. 2018. Injectable maltodextrin-based micelle/hydrogel composites for simvastatin-controlled release. Biomacromolecules. 19(12):4554–4564.
  • Zarandi MA, Zahedi P, Rezaeian I, Salehpour A, Gholami M, Motealleh B. 2015. Drug release, cell adhesion and wound healing evaluations of electrospun carboxymethyl chitosan/polyethylene oxide nanofibres containing phenytoin sodium and vitamin C. IET Nanobiotechnol. 9(4):191–200.
  • Zhao L, Niu L, Liang H, Tan H, Liu C, Zhu F. 2017. pH and glucose dual-responsive injectable hydrogels with insulin and fibroblasts as bioactive dressings for diabetic wound healing. ACS Appl Mater Interfaces. 9(43):37563–37574.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.