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Research Articles

Nano-emulsomes for back of the eye delivery of Ganciclovir: formulation optimization, characterization & in vitro/in vivo evaluation

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Pages 535-546 | Received 31 Jan 2023, Accepted 18 May 2023, Published online: 25 May 2023

References

  • Abdullah A, Al-Badr, TD, Ajarim. 2018. Chapter One - Ganciclovir. In: Harry G. Brittain Editor. Profiles of drug substances, excipients and related methodology, Vol 43, Academic Press; Netherlands: Elsevier Science. 1–208.
  • Alshamrani M, Sikder S, Coulibaly F, Mandal A, Pal D, Mitra AK. 2019. Self-Assembling topical nanomicellar formulation to improve curcumin absorption across ocular tissues. AAPS PharmSciTech. 20(7):254.
  • Amselem S, Aviv H, Friedman D, Lowell GH. Solid fat nanoemulsions as vaccine delivery vehicles. U.S. Patent 5716637, 02/10/1998.
  • Araújo J, Nikolic S, Egea MA, Souto EB, Garcia ML. 2011. Nanostructured lipid carriers for triamcinolone acetonide delivery to the posterior segment of the eye. Colloids Surf B Biointerfaces. 88(1):150–157.
  • Araújo J, Vega E, Lopes C, Egea MA, Garcia ML, Souto EB. 2009. Effect of polymer viscosity on physicochemical properties and ocular tolerance of FB-loaded PLGA nanospheres. Colloids Surf B Biointerfaces. 72(1):48–56.
  • Asasutjarit R, Managit C, Phanaksri T, Treesuppharat W, Fuongfuchat A. 2020. Formulation development and in vitro evaluation of transferrin-conjugated liposomes as a carrier of ganciclovir targeting the retina. Int J Pharm. 577:119084.
  • Chou TY, Hong BY. 2014. Ganciclovir ophthalmic gel 0.15% for the treatment of acute herpetic keratitis: background, effectiveness, tolerability, safety, and future applications. Ther Clin Risk Manag. 10:665–681.
  • Das B, Nayak AK, Mallick S. 2022. Lipid-based nanocarriers for ocular drug delivery: an updated review. J Drug Deliv Sci Technol. 76:103780.
  • De Oliveira IF, Barbosa EJ, Peters MCC, Henostroza MAB, Yukuyama MN, Dos Santos Neto E, Löbenberg R, Bou-Chacra N. 2020. Cutting-edge advances in therapy for the posterior segment of the eye: solid lipid nanoparticles and nanostructured lipid carriers. Int J Pharm. 589:119831.
  • Del Amo EM, Rimpelä A-K, Heikkinen E, Kari OK, Ramsay E, Lajunen T, Schmitt M, Pelkonen L, Bhattacharya M, Richardson D, et al. 2017. Pharmacokinetic aspects of retinal drug delivery. Prog Retin Eye Res. 57:134–185.
  • Fujisawa T, Miyai H, Hironaka K, Tsukamoto T, Tahara K, Tozuka Y, Ito M, Takeuchi H. 2012. Liposomal diclofenac eye drop formulations targeting the retina: formulation stability improvement using surface modification of liposomes. Int J Pharm. 5436(1–2):564–567.
  • Gan L, Wang J, Jiang M, Bartlett H, Ouyang D, Eperjesi F, Liu J, Gan Y. 2013. Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers. Drug Discov Today. 18(5–6):290–297.
  • Gill B, Singh J, Sharma V, Kumar SH. 2012. Emulsomes: an emerging vesicular drug delivery system. Asian J Pharm. 6(2):87–94.
  • Han H, Li S, Xu M, Zhong Y, Fan W, Xu J, Zhou T, Ji J, Ye J, Yao K. 2023. Polymer- and lipid-based nanocarriers for ocular drug delivery: current status and future perspectives. Adv Drug Deliv Rev. 196:114770. Epub ahead of print. PMID: 36894134.
  • Hironaka K, Inokuchi Y, Tozuka Y, Shimazawa M, Hara H, Takeuchi H. 2009. Design and evaluation of a liposomal delivery system targeting the posterior segment of the eye. J Control Release. 136(3):247–253.
  • Jounaki K, Makhmalzadeh BS, Feghhi M, Heidarian A. 2021. Topical ocular delivery of vancomycin loaded cationic lipid nanocarriers as a promising and non-invasive alternative approach to intravitreal injection for enhanced bacterial endophthalmitis management. Eur J Pharm Sci. 167:105991.
  • Kamani P, Parikh K, Kapadia R, Sawant K. 2019. Phospholipid based ultra-deformable nanovesicular gel for transcutaneous application: QbD based optimization, characterization and pharmacodynamic profiling. J Drug Deliv Sci Technol. 51:152–163.
  • Kapadia R, Khambete H, Katara R, Ramteke S. 2009. A novel approach for ocular delivery of acyclovir via niosomes entrapped in situ hydrogel system. J. Pharm. Res. 2:745–751.
  • Kapadia R, Parikh K, Jain M, Sawant K. 2021. Topical instillation of triamcinolone acetonide-loaded emulsomes for posterior ocular delivery: statistical optimization and in vitro-in vivo studies. Drug Deliv Transl Res. 11(3):984–999.
  • Kjar A, Wadsworth I, Vargis E, Britt DW. 2022. Poloxamer 188 - quercetin formulations amplify in vitro ganciclovir antiviral activity against cytomegalovirus. Antiviral Res. 204:105362.
  • Kumar A, Sawant KK. 2014. Application of multiple regression analysis in optimization of anastrozole-loaded PLGA nanoparticles. J Microencapsul. 31(2):105–114.
  • Lakhani P, Patil A, Majumdar S. 2018. Recent advances in topical nano drug-delivery systems for the anterior ocular segment. Ther Deliv. 9(2):137–153.
  • Löscher M, Seiz C, Hurst J, Schnichels S. 2022. Topical drug delivery to the posterior segment of the eye. Pharmaceutic. 14(1):134.
  • Markham A, Faulds D. 1994. An update of its therapeutic use in cytomegalovirus infection. Drugs. 48(3):455–484.
  • Ng WS, Lee CS, Cheng S-F, Chuah CH, Wong SF. 2018. Biocompatible polyurethane scaffolds prepared from glycerol monostearate-derived polyester polyol. J Polym Environ. 26(7):2881–2900.
  • Paliwal R, Paliwal SR, Mishra N, Mehta A, Vyas SP. 2009. Engineered chylomicron mimicking carrier emulsome for lymph targeted oral delivery of methotrexate. Int J Pharm. 380(1–2):181–188. Epub 2009 Jul 2. PMID: 19576973.
  • Rathod LV, Kapadia R, Sawant KK. 2017. A novel nanoparticles impregnated ocular insert for enhanced bioavailability to posterior segment of eye: in vitro, in vivo and stability studies. Mater Sci Eng C Mater Biol Appl. 71:529–540.
  • Sarbajn R, Preetam A, Devi AS, Suryanarayan MV, Sethi M, Dutta D. 2011. Studies on crystal modifications of ganciclovir. Mol Crystal and Liquid Crystals. 537(1):141–154.
  • Shen Y, Tu J. 2007. Preparation and ocular pharmacokinetics of ganciclovir liposomes. Aaps J. 9(3):E371–7.
  • Suri R, Neupane YR, Mehra N, Jain GK, Kohli K. 2020. Sirolimus loaded polyol modified liposomes for the treatment of posterior segment eye diseases. Med Hypotheses. 136:109518.
  • Takahashi Y, Koike M, Honda H, Ito Y, Sakaguchi H, Suzuki H, Nishiyama N. 2008. Development of the short time exposure (STE) test: an in vitro eye irritation test using SIRC cells. Toxicol in Vitro. 22(3):760–770.
  • Tambe V, Raval N, Gondaliya P, Bhattacharya P, Kalia K, Tekade RK. 2021. To investigate fit-to-purpose nanocarrier for non-invasive drug delivery to posterior segment of eye. J Drug Deliv Sci Technol. 61:102222.
  • Tasharrofi N, Nourozi M, Marzban A. 2022. How liposomes pave the way for ocular drug delivery after topical administration. J Drug Deliv Sci Technol. 67:103045.
  • Toniazzo T, Peres MS, Ramos AP, Pinho SC. 2017. Encapsulation of quercetin in liposomes by ethanol injection and physicochemical characterization of dispersions and lyophilized vesicles. Food Bioscienc. 19:17–25.
  • Ucisik MH, Sleytr UB, Schuster B. 2015. Emulsomes meet S-layer proteins: an emerging targeted drug delivery system. Curr Pharm Biotechnol. 16(4):392–405.
  • Vyas SP, Subhedar R, Jain S. 2006. Development and characterization of emulsomes for sustained and targeted delivery of an antiviral agent to liver. J Pharm Pharmacol. 58(3):321–326. PMID: 16536898.
  • Wang Y, Xu X, Gu Y, Cheng Y, Cao F. 2018. Recent advance of nanoparticle-based topical drug delivery to the posterior segment of the eye. Expert Opin Drug Deliv. 15(7):687–701.
  • Weng Y, Liu J, Jin S, Guo W, Liang X, Hu Z. 2017. Nanotechnology-based strategies for treatment of ocular disease. Acta Pharm Sin B. 7(3):281–291.
  • Yadav M, Schiavone N, Guzman-Aranguez A, Giansanti F, Papucci L, Perez de Lara MJ, Singh M, Kaur IP. 2020. Atorvastatin-loaded solid lipid nanoparticles as eye drops: proposed treatment option for age-related macular degeneration (AMD). Drug Deliv Transl Res. 10(4):919–944.

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