50
Views
0
CrossRef citations to date
0
Altmetric
Research Articles

Nano-crystallization of flubendazole for enhanced dissolution rate and improved in vivo efficacy against Trichinella spiralis

, ORCID Icon, , , &
Pages 571-583 | Received 17 Feb 2023, Accepted 06 Jun 2023, Published online: 15 Jun 2023

References

  • Alshaikh RA, Essa EA, El Maghraby GM. 2020. Preparation of stabilized submicron fenofibrate crystals on niacin as a hydrophilic hydrotropic carrier. Pharm Dev Technol. 25(2):168–177.
  • Amin K, Dannenfelser RM, Zielinski J, Wang B. 2004. Lyophilization of polyethylene glycol mixtures. J Pharm Sci. 93(9):2244–2249.
  • Ashour DS, Abou Rayia DM, Saad AE, El-Bakary RH. 2016. Nitazoxanide anthelmintic activity against the enteral and parenteral phases of Trichinellosis in experimentally infected rats. Exp Parasitol. 170:28–35.
  • Baghel S, Cathcart H, O'Reilly NJ. 2016. Polymeric amorphous solid dispersions: a review of amorphization, crystallization, stabilization, solid-state characterization, and aqueous solubilization of biopharmaceutical classification system class II drugs. J Pharm Sci. 105(9):2527–2544.‏
  • Chi Y, Xu W, Yang Y, Yang Z, Lv H, Yang S, Lin Z, Li J, Gu J, Hill CL, et al. 2015. Three candesartan salts with enhanced oral bioavailability. Crystal Growth Des. 15(8):3707–3714.
  • Chung MS, Joo KH, Quan FS, Kwon HS, Cho SW. 2001. Efficacy of flubendazole and albendazole against Trichinella spiralis in mice. Parasite. 8(2 Suppl):S195–S198.
  • Daebis NAO, El-Massik M, Abdelkader H. 2015. Formulation and characterization of itraconazole oral nanosuspension: methyl cellulose as promising stabilizer. J Drug Develop Clin Trials. 1(1):102.‏
  • de Araujo GLB, Ferreira FF, Bernardes CES, Sato JAP, Gil OM, de Faria DLA, Loebenberg R, Byrn SR, Ghisleni DDM, Bou-Chacra NA, et al. 2018. A new thermodynamically favored flubendazole/maleic acid binary crystal form: structure, energetics, and in silico PBPK model-based investigation. Crystal Growth Des. 18(4):2377–2386.
  • de Assis JMC, Barbosa EJ, Bezzon VDN, Lourenço FR, Carvalho FMS, Matos JR, Araci Bou-Chacra N, Benmore CJ, Byrn SR, Costa FN, et al. 2022. Hot-melt extrudability of amorphous solid dispersions of flubendazole-copovidone: an exploratory study of the effect of drug loading and the balance of adjuvants on extrudability and dissolution. Int J Pharm. 614:121456.
  • de Souza Gonçalves D, Yukuyama MN, Miyagi MYS, Silva TJV, Lameu C, Bou-Chacra NA, de Araujo GLB. 2023. Revisiting flubendazole through nanocrystal technology: statistical design, characterization and its potential inhibitory effect on xenografted lung tumor progression in mice. J Clust Sci. 34(1):261–272.
  • Dunn IJ, Wright KA. 1985. Cell injury caused by Trichinella spiralis in the mucosal epithelium of B10A mice. J Parasitol. 71(6):757–766.
  • Eid RK, Ashour DS, Essa EA, El Maghraby GM, Arafa MF. 2020. Chitosan coated nanostructured lipid carriers for enhanced in vivo efficacy of albendazole against Trichinella spiralis. Carbohydr Polym. 232:115826.
  • El-Gizawy SA, Osman MA, Arafa MF, El Maghraby G. 2015. Aerosil as a novel co-crystal co-former for improving the dissolution rate of hydrochlorothiazide. Int J Pharm. 478(2):773–778.
  • Elmehy DA, Hasby Saad MA, El Maghraby GM, Arafa MF, Soliman NA, Elkaliny HH, Elgendy DI. 2021. Niosomal versus nano-crystalline ivermectin against different stages of Trichinella spiralis infection in mice. Parasitol Res. 120(7):2641–2658.
  • El-Temsahi MM, El-Mansoury ST. 1995. The effect of flubendazole on the course of Trichinella spiralis infection in mice: parasitological study. J Egypt Soc Parasitol. 25(2):453–459.
  • Essa EA, Elmarakby AO, Donia AM, El Maghraby GM. 2017. Controlled precipitation for enhanced dissolution rate of flurbiprofen: development of rapidly disintegrating tablets. Drug Dev Ind Pharm. 43(9):1430–1439.
  • Farhadi M, Haniloo A, Rostamizadeh K, Faghihzadeh S. 2018. Efficiency of flubendazole-loaded mPEG-PCL nanoparticles: a promising formulation against the protoscoleces and cysts of Echinococcus granulosus. Acta Trop. 187:190–200.
  • Guo M, Fu Q, Wu C, Guo Z, Li M, Sun J, He Z, Yang L. 2015. Rod shaped nanocrystals exhibit superior in vitro dissolution and in vivo bioavailability over spherical like nanocrystals: a case study of lovastatin. Colloids Surf B Biointerfaces. 128:410–418.
  • Imono M, Uchiyama H, Yoshida S, Miyazaki S, Tamura N, Tsutsumimoto H, Kadota K, Tozuka Y. 2020. The elucidation of key factors for oral absorption enhancement of nanocrystal formulations: in vitro-in vivo correlation of nanocrystals. Eur J Pharm Biopharm. 146:84–92.
  • Joshi K, Chandra A, Jain K, Talegaonkar S. 2019. Nanocrystalization: an emerging technology to enhance the bioavailability of poorly soluble drugs. Pharm Nanotechnol. 7(4):259–278.
  • Junyaprasert VB, Morakul B. 2015. Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs. Asian J Pharm Sci. 10(1):13–23.
  • Kumar R, Siril PF. 2018. Enhancing the solubility of fenofibrate by nanocrystal formation and encapsulation. AAPS PharmSciTech. 19(1):284–292.
  • Liang LH, Zhao M, Jiang Q. 2002. Melting enthalpy depression of nanocrystals based on surface effect. J Mater Sci Lett. 21(23):1843–1845.
  • Lipinski CALF. 2002. Poor aqueous solubility—an industry wide problem in drug discovery. Am Pharm Rev. 5(3):82–85.
  • Ma J, Liang J, Han J, Zheng M, Zhao H. 2019. Solubility modeling and solvent effect of flubendazole in 12 neat solvents. J Chem Eng Data. 64(3):1237–1243.
  • Nagarwal RC, Kumar R, Dhanawat M, Das N, Pandit JK. 2011. Nanocrystal technology in the delivery of poorly soluble drugs: an overview. Curr Drug Deliv. 8(4):398–406.
  • Naiem NH, Essa EA, Elmaghraby GM. 2018. Enhancing dissolution rate of indomethacin by in situ crystalization; development of orally disintegrating tablets. Int J Pharm Pharm Sci. 10(5):18–23.
  • Ndlovu ST, Ullah N, Khan S, Ramharack P, Soliman M, de Matas M, Shahid M, Sohail M, Imran M, Shah SWA, et al. 2019. Domperidone nanocrystals with boosted oral bioavailability: fabrication, evaluation and molecular insight into the polymer-domperidone nanocrystal interaction. Drug Deliv Transl Res. 9(1):284–297.
  • Oncsik T, Trefalt G, Borkovec M, Szilagyi I. 2015. Specific ion effects on particle aggregation induced by monovalent salts within the Hofmeister series. Langmuir. 31(13):3799–3807.
  • Sezgin Z, Yüksel N, Baykara T. 2006. Preparation and characterization of polymeric micelles for solubilization of poorly soluble anticancer drugs. Eur J Pharm Biopharm. 64(3):261–268.
  • Shah SR, Parikh RH, Chavda JR, Sheth NR. 2014. Glibenclamide nanocrystals for bioavailability enhancement: formulation design, process optimization, and pharmacodynamic evaluation. J Pharm Innov. 9(3):227–237.
  • Shakeel F, Faisal MS. 2010. Caffeine: a potential complexing agent for solubility and dissolution enhancement of celecoxib. Pharm Biol. 48(1):113–115.
  • Sharma M, Mehta I. 2019. Surface stabilized atorvastatin nanocrystals with improved bioavailability, safety and antihyperlipidemic potential. Sci Rep. 9(1):1–11.
  • Soisuwan S, Teeranachaideekul V, Wongrakpanich A, Langguth P, Junyaprasert VB. 2019. Impact of uncharged and charged stabilizers on in vitro drug performances of clarithromycin nanocrystals. Eur J Pharm Biopharm. 137:68–76.
  • Sudha C, Srinivasan K. 2014. Understanding the effect of solvent polarity on the habit modification of monoclinic paracetamol in terms of molecular recognition at the solvent crystal/interface. Cryst Res Technol. 49(11):865–872.
  • Sultan AA, El-Gizawy SA, Osman MA, El Maghraby GM. 2017. Self-dispersing mixed micelles forming systems for enhanced dissolution and intestinal permeability of hydrochlorothiazide. Colloids Surf B Biointerfaces. 149:206–216.
  • Vialpando M, Smulders S, Bone S, Jager C, Vodak D, Van Speybroeck M, Verheyen L, Backx K, Boeykens P, Brewster ME, et al. 2016. Evaluation of three amorphous drug delivery technologies to improve the oral absorption of flubendazole. J Pharm Sci. 105(9):2782–2793.
  • Vigh T, Démuth B, Balogh A, Galata DL, Van Assche I, Mackie C, Vialpando M, Van Hove B, Psathas P, Borbás E, et al. 2017. Oral bioavailability enhancement of flubendazole by developing nanofibrous solid dosage forms. Drug Dev Ind Pharm. 43(7):1126–1133.
  • Wong SM, Kellaway IW, Murdan S. 2006. Enhancement of the dissolution rate and oral absorption of a poorly water soluble drug by formation of surfactant-containing microparticles. Int J Pharm. 317(1):61–68.
  • Yi Y, Tu L, Hu K, Wu W, Feng J. 2015. The construction of puerarin nanocrystals and its pharmacokinetic and in vivo–in vitro correlation (IVIVC) studies on beagle dog. Colloids Surf B Biointerfaces. 133:164–170.
  • Yukuyama MN, Ishida K, de Araujo GLB, Spadari CdC, de Souza A, Löbenberg R, Henostroza MAB, Folchini BR, Peroni CM, Peters MCC. 2021. Rational design of oral flubendazole-loaded nanoemulsion for brain delivery in cryptococcosis. Colloids Surf, A. 630:127631.
  • Zhang J, Lv H, Jiang K, Gao Y. 2011. Enhanced bioavailability after oral and pulmonary administration of baicalein nanocrystal. Int J Pharm. 420(1):180–188.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.