Green polymer altered in-situ gel oral liquid sustainable release preparation of vildagliptin suitable for dysphagic diabetic patients: assessment in-vitro & in-vivo

References

• Attebäck M, Hedin B, Mattsson S. 2022. Formulation optimization of extemporaneous oral liquids containing naloxone and propranolol for pediatric use. Sci Pharm. 90(1):15. doi: 10.3390/scipharm90010015.
   Web of Science ®Google Scholar
• Awasthi R, Kulkarni GT, Ramana MV, de Jesus Andreoli Pinto T, Kikuchi IS, Molim Ghisleni DD, de Souza Braga M, De Bank P, Dua K. 2017. Dual crosslinked pectin-alginate network as sustained release hydrophilic matrix for repaglinide. Int J Biol Macromol. 97:721–732. doi: 10.1016/j.ijbiomac.2017.01.050.
   PubMed Web of Science ®Google Scholar
• Bashir R, Majeed A, Ali T, Farooq S, Khan NA. 2019. Floating Oral In-Situ Gel: a Review. J Drug Delivery Ther. 9(2):442–448. doi: 10.22270/jddt.v9i2.2372.
   Google Scholar
• Bhatta RG, Rudragangaiah S, Birur Kotappa SB. 2019. Formulation, optimization and evaluation of in-situ gelling liquid oral formulation of a novel antidiabetic drug: canagliflozin. IJPER. 53(2s):s121–s128. doi: 10.5530/ijper.53.2s.56.
   Google Scholar
• Cichero JA. 2013. Thickening agents used for dysphagia management: effect on the bioavailability of water, medication, and feelings of satiety. Nutr J. 12:54. doi: 10.1186/1475-2891-12-54.
   PubMed Web of Science ®Google Scholar
• Dewan I, Islam S, Rana MS. 2015. Characterization and compatibility studies of different rate retardant polymer loaded microspheres by solvent evaporation technique: in vitro in vivo study of vildagliptin as a model drug. J Drug Deliv. 2015:496807. doi: 10.1155/2015/496807.
   PubMedGoogle Scholar
• Draget KI, Skjåk-Bræk G, Stokke BT. 2006. Similarities and differences between alginic acid gels and ionically crosslinked alginate gels. Food. Hydrocoll. 20(2-3):170–175. doi: 10.1016/j.foodhyd.2004.03.009.
   Web of Science ®Google Scholar
• Easson M, Villalpando A, Condon BD. 2017. Absorbent properties of carboxymethylated fiber, hydroentangled nonwoven and regenerated cellulose: a comparative study. J. Eng. Fibers Fabr. 12(4):155892501701200. doi: 10.1177/155892501701200408.
   Web of Science ®Google Scholar
• El Maghraby GM, Elsisi AE, Elmeshad GA. 2015. Development of liquid oral sustained release formulations of nateglinide: in vitro and in vivo evaluation. J Drug Delivery Sci Technol. 29:70–77. doi: 10.1016/j.jddst.2015.06.011.
   Web of Science ®Google Scholar
• El Maghraby GM, Elzayat EM, Alanazi FK. 2012. Development of modified in situ gelling oral liquid sustained release formulation of dextromethorphan. Drug Dev Ind Pharm. 38(8):971–978. doi: 10.3109/03639045.2011.634811.
   PubMed Web of Science ®Google Scholar
• Elkarray SM, Farid RM, Abd-Alhaseeb MM, Omran GA, Habib DA. 2022. Intranasal repaglinide-solid lipid nanoparticles integrated in situ gel outperform conventional oral route in hypoglycemic activity. J Drug Delivery Sci Technol. 68:103086. doi: 10.1016/j.jddst.2021.103086.
   Web of Science ®Google Scholar
• El-Masry SM, Helmy SA. 2020. Hydrogel-based matrices for controlled drug delivery of etamsylate: prediction of in-vivo plasma profiles. Saudi Pharm J. 28(12):1704–1718. doi: 10.1016/j.jsps.2020.10.016.
   PubMed Web of Science ®Google Scholar
• Federiuk IF, Casey HM, Quinn MJ, Wood MD, Ward KW. 2004. Induction of type-1 diabetes mellitus in laboratory rats by use of alloxan: route of administration, pitfalls, and insulin treatment. Compar Med. 54(3):252–257.
   PubMed Web of Science ®Google Scholar
• Fu S, Thacker A, Sperger DM, Boni RL, Buckner IS, Velankar S, Munson EJ, Block LH. 2011. Relevance of rheological properties of sodium alginate in solution to calcium alginate gel properties. AAPS PharmSciTech. 12(2):453–460. doi: 10.1208/s12249-011-9587-0.
   PubMed Web of Science ®Google Scholar
• George NS, Rangan V, Geng Z, Khan F, Kichler A, Gabbard S, Ganocy S, Fass R. 2017. Distribution of esophageal motor disorders in diabetic patients with dysphagia. J Clin Gastroenterol. 51(10):890–895. doi: 10.1097/MCG.0000000000000894.
   PubMed Web of Science ®Google Scholar
• Higuchi T. 1963. Mechanism of sustained‐action medication. J Pharm Sci. 52:1145–1149. doi: 10.1002/jps.2600521210.
   PubMed Web of Science ®Google Scholar
• Holloway RH, Tippett D, Horowitz M, Maddox AF, Moten J, Russo A. 1999. Relationship between esophageal motility and transit in patients with type I diabetes mellitus. Am J Gastroenterol. 94(11):3150–3157. doi: 10.1111/j.1572-0241.1999.01508.x.
   PubMed Web of Science ®Google Scholar
• Ighodaro OM, Adeosun AM, Akinloye OA. 2017. Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies. Medicina. 53(6):365–374. doi: 10.1016/j.medici.2018.02.001.
   PubMedGoogle Scholar
• Itoh K, Hatakeyama T, Shimoyama T, Miyazaki S, D'Emanuele A, Attwood D. 2011. In situ gelling formulation based on methylcellulose/pectin system for oral-sustained drug delivery to dysphagic patients. Drug Dev Ind Pharm. 37(7):790–797. doi: 10.3109/03639045.2010.541465.
   PubMed Web of Science ®Google Scholar
• Itoh K, Kubo W, Fujiwara M, Watanabe H, Miyazaki S, Attwood D. 2006. The influence of gastric acidity and taste masking agent on in situ gelling pectin formulations for oral sustained delivery of acetaminophen. Biol Pharm Bull. 29(2):343–347. doi: 10.1248/bpb.29.343.
   PubMed Web of Science ®Google Scholar
• Itoh K, Yahaba M, Takahashi A, Tsuruya R, Miyazaki S, Dairaku M, Togashi M, Mikami R, Attwood D. 2008. In situ gelling xyloglucan/pectin formulations for oral sustained drug delivery. Int J Pharm. 22; 356(1-2):95–101. doi: 10.1016/j.ijpharm.2007.12.049.
   PubMedGoogle Scholar
• Jacob S, Mathew A, Shyma MS. 2020. oral in-situ gelling system. J. Pharm. Sci. & Res. 12(8):1056–1061.
   Google Scholar
• Jain D, Bar-Shalom D. 2014. Alginate drug delivery systems: application in the context of pharmaceutical and biomedical research. Drug Dev Ind Pharm. 40(12):1576–1584. doi: 10.3109/03639045.2014.917657.
   PubMed Web of Science ®Google Scholar
• Javanbakht S, Shaabani A. 2019. Carboxymethyl cellulose-based oral delivery systems. Int J Biol Macromol. 133:21–29. doi: 10.1016/j.ijbiomac.2019.04.079.
   PubMed Web of Science ®Google Scholar
• Karkos PD, Papouliakos S, Karkos CD, Theochari EG. 2009. Current evaluation of the dysphagic patient. Hippokratia. 13(3):141–146.
   PubMed Web of Science ®Google Scholar
• Kassem AA, Abd El-Alim SH, Basha M, Salama A. 2017. Phospholipid complex enriched micelles: a novel drug delivery approach for promoting the anti-diabetic effect of repaglinide. Eur J Pharm Sci. 99:75–84. doi: 10.1016/j.ejps.2016.12.005.
   PubMed Web of Science ®Google Scholar
• Kelly J, D'Cruz G, Wright D. 2009. A qualitative study of the problems surrounding medicine administration to patients with dysphagia. Dysphagia. 24(1):49–56. doi: 10.1007/s00455-008-9170-3.
   PubMed Web of Science ®Google Scholar
• Kelly J, D'Cruz G, Wright D. 2010. Patients with dysphagia: experiences of taking medication. J Adv Nurs. 66(1):82–91. doi: 10.1111/j.1365-2648.2009.05145.x.
   PubMed Web of Science ®Google Scholar
• Khan KA. 1975. The concept of dissolution efficiency. J Pharm Pharmacol. 27(1):48–49. doi: 10.1111/j.2042-7158.1975.tb09378.x.
   PubMed Web of Science ®Google Scholar
• Kubo W, Miyazaki S, Attwood D. 2003. Oral sustained delivery of paracetamol from in situ-gelling gellan and sodium alginate formulations. Int J Pharm. 258(1-2):55–64. doi: 10.1016/s0378-5173(03)00163-7.
   PubMedGoogle Scholar
• Lauster CD, McKaveney TP, Muench SV. 2007. Vildagliptin: a novel oral therapy for Type 2 diabetes mellitus. Am J Health Syst Pharm. 64(12):1265–1273. doi: 10.2146/ajhp060564.
   PubMed Web of Science ®Google Scholar
• Layek B, Mandal S. 2020. Natural polysaccharides for controlled delivery of oral therapeutics: a recent update. Carbohydr Polym. 230:115617. doi: 10.1016/j.carbpol.2019.115617.
   PubMed Web of Science ®Google Scholar
• Lee KY, Mooney DJ. 2012. Alginate: properties and biomedical applications. Prog Polym Sci. 37(1):106–126. doi: 10.1016/j.progpolymsci.2011.06.003.
   PubMed Web of Science ®Google Scholar
• Lenzen S, Munday R. 1991. Thiol-group reactivity, hydrophilicity and stability of alloxan, its reduction products, and its N-methyl derivatives and a comparison with ninhydrin. Biochem Pharmacol. 42(7):1385–1391. doi: 10.1016/0006-2952(91)90449-f.
   PubMed Web of Science ®Google Scholar
• Miehle E, Bader-Mittermaier S, Schweiggert-Weisz U, Hauner H, Eisner P. 2021. Effect of physicochemical properties of carboxymethyl cellulose on diffusion of glucose. Nutrients. 13(5):1398. doi: 10.3390/nu13051398.
   PubMed Web of Science ®Google Scholar
• Miyazaki S, Aoyama H, Kawasaki N, Kubo W, Attwood D. 1999. In situ-gelling gellan formulations as vehicles for oral drug delivery. J Control Release. 60(2-3):287–295. doi: 10.1016/s0168-3659(99)00084-x.
   PubMed Web of Science ®Google Scholar
• Miyazaki S, Kubo W, Attwood D. 2000. Oral sustained delivery of theophylline using in-situ gelation of sodium alginate. J Control Release. 67(2-3):275–280. doi: 10.1016/s0168-3659(00)00214-5.
   PubMed Web of Science ®Google Scholar
• Molaei MA, Osouli-Bostanabad K, Adibkia K, Shokri J, Asnaashari S, Javadzadeh Y. 2018. Enhancement of ketoconazole dissolution rate by the liquisolid technique. Acta Pharm. 168(3):325–336. doi: 10.2478/acph-2018-0025.
   PubMed Web of Science ®Google Scholar
• National Dysphagia Diet Task Force. 2002. National Dysphagia Diet: standardization for Optimal Care. Chicago, IL: American Dietetic Association.
   Google Scholar
• Pourjavadi A, Barzegar S, Mahdavinia GR. 2006. MBA-crosslinked Na-Alg/CMC as smart full-polysaccharide superabsorbent hydrogels. Carbohydr Polym. 66(3):386–395. doi: 10.1016/j.carbpol.2006.03.013.
   Web of Science ®Google Scholar
• Qinna NA, Badwan AA. 2015. Impact of streptozotocin on altering normal glucose homeostasis during insulin testing in diabetic rats compared to normoglycemic rats. Drug Des Devel Ther. 9:2515–2525. doi: 10.2147/DDDT.S79885.
   PubMed Web of Science ®Google Scholar
• Refaat R, Sakr A, Salama M, El Sarha A. 2016. Combination of vildagliptin and pioglitazone in experimental type 2 diabetes in male rats. Drug Dev Res. 77(6):300–309. doi: 10.1002/ddr.21324.
   PubMed Web of Science ®Google Scholar
• Riyajan S-A, Nuim J. 2013. Interaction of green polymer blend of modified sodium alginate and carboxylmethyl cellulose encapsulation of turmeric extract. Internatl J Polym Sci. 2013:1–10. doi: 10.1155/2013/364253.
   Web of Science ®Google Scholar
• Rosilio V, Albrecht G, Baszkin A, Merle L. 2000. Surface properties of hydrophobically modified carboxymethylcellulose derivatives. Colloids Surf B. 19(2):163–172. doi: 10.1016/S0927-7765(00)00151-X.
   Web of Science ®Google Scholar
• Shaikh HK, Kshirsagar RV, Patil SG. 2015. Mathematical models for drug release characterization: a review. World J Pharm Pharm Sci. 4:324–338.
   Google Scholar
• Shimoyama T, Itoh K, Kobayashi M, Miyazaki S, D'Emanuele A, Attwood D. 2012. Oral liquid in situ gelling methylcellulose/alginate formulations for sustained drug delivery to dysphagic patients. Drug Dev Ind Pharm. 38(8):952–960. doi: 10.3109/03639045.2011.634809.
   PubMed Web of Science ®Google Scholar
• Ullah F, Othman MB, Javed F, Ahmad Z, Md Akil H. 2015. Classification, processing and application of hydrogels: a review. Mater Sci Eng C Mater Biol Appl. 57:414–433. 1doi: 10.1016/j.msec.2015.07.053.
   PubMed Web of Science ®Google Scholar
• Wan T, Zhou Z, Huang R, Zou C, Xu M, Cheng W, Li R. 2014. Synthesis and swelling properties of microcrystal muscovite composite superabsorbent. Appl. Clay Sci. 101:199–204. doi: 10.1016/j.clay.2014.07.035.
   Web of Science ®Google Scholar
• Wang Y, Wang W, Shi X, Wang A. 2013. Enhanced swelling and responsive properties of an alginate-based superabsorbent hydrogel by sodium p-styrenesulfonate and attapulgite nanorods. Polym. Bull. 70(4):1181–1193. doi: 10.1007/s00289-012-0901-0.
   Web of Science ®Google Scholar
• Wilkinson JM, Codipilly DC, Wilfahrt RP. 2021. Dysphagia: evaluation and collaborative management. Am Fam Physician. 103(2):97–106.
   PubMed Web of Science ®Google Scholar
• Yadav VK, Kumar B, Prajapati SK, Shafaat K. 2011. Design and evaluation of mucoadhesive microspheres of repaglinide for oral controlled release. Int. J. Drug Deliv. 1:357–370.
   Google Scholar
• Yang XH, Zhu WL. 2007. Viscosity properties of sodium carboxymethylcellulose solutions. Cellulose. 14(5):409–417. doi: 10.1007/s10570-007-9137-9.
   Web of Science ®Google Scholar
• Zheng J, Zeng R, Zhang F, Kan J. 2019. Effects of sodium carboxymethyl cellulose on rheological properties and gelation behaviors of sodium alginate induced by calcium ions. LWT - Food Science and Technology. 103:131–138. doi: 10.1016/j.lwt.2018.12.081.
   Web of Science ®Google Scholar