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Pharmaceutical Development and Technology Volume 12, 2007 - Issue 1
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Research Article

Percolation Theory and the Role of Maize Starch as a Disintegrant for a Low Water-Soluble Drug

Go Kimura Institute of Pharmaceutical Technology, Pharmacenter, University of Basel, Basel, Switzerland; Pharmaceutical Development Department, Manufacturing Technology Research Laboratories, Shionogi & Co., Ltd., Hyogo, Japan
,
Maxim Puchkov Institute of Pharmaceutical Technology, Pharmacenter, University of Basel, Basel, Switzerland
,
Gabriele Betz Institute of Pharmaceutical Technology, Pharmacenter, University of Basel, Basel, Switzerland
&
Hans Leuenberger Institute of Pharmaceutical Technology, Pharmacenter, University of Basel, Basel, Switzerland
Pages 11-19 | Received 03 Apr 2006, Accepted 24 May 2006, Published online: 07 Oct 2008

REFERENCES

  • http://www.fda.gov/oc/initiatives/criticalpath/whitepaper.html, Challenge and Opportunity on the Critical Path to New Medical Products, U.S. Department of Health and Human Services: Food and Drug Administration Rockville, Maryland, 2004
  • Patel N.R., Hopponen R.E. Mechanism of action of starch as a disintegrating agent in aspirin tablets. J. Pharm. Sci. 1966; 55(10)1065–1068
  • Nogami H., Hasegawa J., Miyamoto M. Studies on powdered preparations. XX. Disintegration of the aspirin tablets containing starches as disintegrating agent. Chem. Pharm. Bull. 1967; 15(3)279–289
  • Commons K.C., Bergen A., Walker G.C. Influence of starch concentration on the disintegration time of tolbutamide tablets. J. Pharm. Sci. 1968; 57(7)1253–1255
  • Nakai Y., Nakajima S. Relationship between configuration of starch grains in tablet and tablet disintegration. Yakugaku Zasshi. 1977; 97(11)1168–1173
  • Yuasa H., Kanaya Y. Studies on internal structure of tablets. II. Effect of the critical disintegrator amount on the internal structure of tablets. Chem. Pharm. Bull. 1986; 34(12)5133–5139
  • Leuenberger H., Rohera B.D., Hass Ch. Percolation theory-a novel approach to solid dosage form design. Int. J. Pharm. 1987; 38: 109–115
  • Ringard J., Guyot-Hermann A.M. Calculation of disintegrant critical concentration in order to optimize tablets disintegration. Drug Dev. Ind. Pharm. 1988; 14(15–17)2321–2339
  • Luginbuehl R., Leuenberger H. Use of percolation theory to interpret water uptake, disintegration time and intrinsic dissolution rate of tablets consisting of binary mixtures. Pharm. Acta Helv. 1994; 69: 127–134
  • Luginbuehl R. Anwendung der Perkolationstheorie zur Untersuchung des Zerfallsprozesses, der Wasseraufnahme und der Wirkstofffreisetzung von binaeren Tablettensystemen. University of Basel, Basel 1994, PhD thesis
  • Stauffer D., Aharony A. Introduction to percolation theory, 2nd. CRC Press, Florida 1994; 181
  • Kimura G., Betz G., Leuenberger H. Influence loading volume of mefenamic acid on granules and tablet characteristics using a compaction simulator. Pharm. Dev. Technol. 2006, in press
  • Levin M., Tsygan L., Dukler S. Press simulation apparatus and methods. International Patent PCT/US98/27421, December 23, 1998
  • Wahba G. Spline models for observational data. Roy. Stat. Soc. Ser. B. Society for industrial and applied mathematics, Philadelphia, PA 1990; 10: 133–150
  • Kaseda Ch. M.L. Lucian, M. NeamtuResponse surface methodology using a spline algorithm. Geometric Modeling and Computing, , Seattle 2003; 341–352
  • Takayama K. Formulation design and optimization of solid dosage forms based on a multivariate spline interpolation. Pharm. Tech. Japan. 2002; 18(10)139–146
  • Leuenberger H. The application of percolation theory in powder technology. Adv. Powder Technol. 1999; 10(4)323–353
  • Marquardt D.W. An algorithm for least-squares estimation of non-linear parameters. J. Soc. Ind. Appl. Math. 1963; 11: 431–441
  • Leuenberger H. Pharmaceutical technology: drug delivery, formulation, and process research. Chimia. 2006; 60: 40–45

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