1,129
Views
4
CrossRef citations to date
0
Altmetric
Original Contributions

Intranasal Fentanyl versus Subcutaneous Fentanyl for Pain Management in Prehospital Patients with Acute Pain: A Retrospective Analysis

Pages 760-768 | Received 01 Oct 2019, Accepted 10 Dec 2019, Published online: 23 Jan 2020

References

  • American College of Emergency Physicians. Clinical policy for procedural sedation and analgesia in the emergency department. Ann Emerg Med. 1998;31:663–677.
  • Gausche-Hill M, Brown KM, Oliver ZJ, Sasson C, Dayan PS, Eschmann NM, Weik TS, Lawner BJ, Sahni R, Falck-Ytter Y, et al. An evidence-based guideline for prehospital analgesia in trauma. Prehosp Emerg Care. 2014;18: 25–34. doi:10.3109/10903127.2013.844873.
  • Hewes HA, Dai M, Mann NC, Baca T, Taillac P. Prehospital pain management: disparity by age and race. Prehosp Emerg Care. 2018;22:189–197. doi:10.1080/10903127.2017.1367444.
  • Parker M, Rodgers A. Management of pain in pre-hospital settings. Emerg Nurse. 2015;23:16–21. doi:10.7748/en.23.3.16.e1445.
  • Swor R, McEachin CM, Seguin D, Grall KH. Prehospital pain management in children suffering traumatic injury. Prehosp Emerg Care. 2005;9:40–43. doi:10.1080/10903120590891930.
  • Lebon J, Fournier F, Begin F, Hebert D, Fleet R, Foldes-Busque G, Tanguay A. Subcutaneous fentanyl administration: a novel approach for pain management in a rural and suburban prehospital setting. Prehosp Emerg Care. 2016;20:1–9.
  • Fields JM, Piela NE, Au AK, Ku BS. Risk factors associated with difficult venous access in adult ED patients. Am J Emerg Med. 2014;32:1179–1182. doi:10.1016/j.ajem.2014.07.008.
  • Hochreiter MC, Barton LL. Epidemiology of needlestick injury in emergency medical service personnel. J Emerg Med. 1988;6:9–12. doi:10.1016/0736-4679(88)90243-0.
  • Prottengeier J, Albermann M, Heinrich S, Birkholz T, Gall C, Schmidt J. The prehospital intravenous access assessment: a prospective study on intravenous access failure and access delay in prehospital emergency medicine. Eur J Emerg Med. 2015;23:442–447.
  • Cooper IM. Morphine for postoperative analgesia. A comparison of intramuscular and subcutaneous routes of administration. Anaesth Intensive Care. 1996;24:574–578. doi:10.1177/0310057X9602400512.
  • Capper SJ, Loo S, Geue JP, Upton RN, Ong J, Macintyre PE, Ludbrook GL. Pharmacokinetics of fentanyl after subcutaneous administration in volunteers. Eur J Anaesthesiol. 2010;27:241–246. doi:10.1097/EJA.0b013e328331a361.
  • Bailey AM, Baum RA, Horn K, Lewis T, Morizio K, Schultz A, Weant K, Justice SN. Review of intranasally administered medications for use in the emergency department. J Emerg Med. 2017;53:38–48. doi:10.1016/j.jemermed.2017.01.020.
  • Corrigan M, Wilson SS, Hampton J. Safety and efficacy of intranasally administered medications in the emergency department and prehospital settings. Am J Health Syst Pharm. 2015;72:1544–1554. doi:10.2146/ajhp140630.
  • Murphy AP, Hughes M, Mccoy S, Crispino G, Wakai A, O’Sullivan R. Intranasal fentanyl for the prehospital management of acute pain in children. Eur J Emerg Med. 2017;24:450–454. doi:10.1097/MEJ.0000000000000389.
  • Prommer E, Thompson L. Intranasal fentanyl for pain control: current status with a focus on patient considerations. Patient Prefer Adherence. 2011;5:157–164. doi:10.2147/PPA.S7665.
  • Schaefer JA, Mlekoday TJ. Time to opioid administration after implementation of an intranasal fentanyl protocol. Am J Emerg Med. 2015;33:1805–1807. doi:10.1016/j.ajem.2015.08.050.
  • Rech MA, Barbas B, Chaney W, Greenhalgh E, Turck C. When to pick the nose: out-of-hospital and emergency department intranasal administration of medications. Ann Emerg Med. 2017;70:203–211. doi:10.1016/j.annemergmed.2017.02.015.
  • Mudd S. Intranasal fentanyl for pain management in children: a systematic review of the literature. J Pediatr Health Care. 2011;25:316–322. doi:10.1016/j.pedhc.2010.04.011.
  • Hansen MS, Mathiesen O, Trautner S, Dahl JB. Intranasal fentanyl in the treatment of acute pain–a systematic review. Acta Anaesthesiol Scand. 2012;56:407–419. doi:10.1111/j.1399-6576.2011.02613.x.
  • Panagiotou I, Mystakidou K. Intranasal fentanyl: from pharmacokinetics and bioavailability to current treatment applications. Expert Rev Anticancer Ther. 2010;10:1009–1021. doi:10.1586/era.10.77.
  • Tanguay A, Dallaire R, Hebert D, Begin F, Fleet R. Rural patient access to primary percutaneous coronary intervention centers is improved by a novel integrated telemedicine prehospital system. J Emerg Med. 2015;49:657–664. doi:10.1016/j.jemermed.2015.05.009.
  • Jennings PA, Cameron P, Bernard S. Measuring acute pain in the prehospital setting. Emerg Med J. 2009;26:552–555. doi:10.1136/emj.2008.062539.
  • McLean SA, Domeier RM, DeVore HK, Hill EM, Maio RF, Frederiksen SM. The feasibility of pain assessment in the prehospital setting. Prehosp Emerg Care. 2004;8:155–161. doi:10.1016/j.prehos.2003.12.006.
  • Kelly CA, Upex A, Bateman DN. Comparison of consciousness level assessment in the poisoned patient using the alert/verbal/painful/unresponsive scale and the Glasgow coma scale. Ann Emerg Med. 2004;44:108–113. doi:10.1016/j.annemergmed.2004.03.028.
  • Borland M, Milsom S, Esson A. Equivalency of two concentrations of fentanyl administered by the intranasal route for acute analgesia in children in a paediatric emergency department: a randomized controlled trial. Emerg Med Australas. 2011;23:202–208. doi:10.1111/j.1742-6723.2011.01391.x.
  • Foster D, Upton R, Christrup L, Popper L. Pharmacokinetics and pharmacodynamics of intranasal versus intravenous fentanyl in patients with pain after oral surgery. Ann Pharmacother. 2008;42:1380–1387. doi:10.1345/aph.1L168.
  • Bijur PE, Chang AK, Esses D, Gallagher EJ. Identifying the minimum clinically significant difference in acute pain in the elderly. Ann Emerg Med. 2010;56:517–521 e1. doi:10.1016/j.annemergmed.2010.02.007.
  • Cepeda MS, Africano JM, Polo R, Alcala R, Carr DB. What decline in pain intensity is meaningful to patients with acute pain? Pain. 2003;105:151–157. doi:10.1016/S0304-3959(03)00176-3.
  • Christrup LL, Foster D, Popper LD, Troen T, Upton R. Pharmacokinetics, efficacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction: a randomized, double-blind, double-dummy, two-way, crossover study. Clin Ther. 2008;30:469–481. doi:10.1016/j.clinthera.2008.03.001.
  • Abbuhl FB, Reed DB. Time to analgesia for patients with painful extremity injuries transported to the emergency department by ambulance. Prehosp Emerg Care. 2003;7:445–447.
  • McEachin CC, McDermott JT, Swor R. Few emergency medical services patients with lower-extremity fractures receive prehospital analgesia. Prehosp Emerg Care. 2002;6:406–410. doi:10.1080/10903120290938030.
  • Murphy A, O'Sullivan R, Wakai A, Grant TS, Barrett MJ, Cronin J, McCoy SC, Hom J, Kandamany N. Intranasal fentanyl for the management of acute pain in children. Cochrane Database Syst Rev. 2014;10(10):CD009942.
  • Fleet J, Belan I, Jones MJ, Ullah S, Cyna AM. A comparison of fentanyl with pethidine for pain relief during childbirth: a randomised controlled trial. BJOG: Int J Obstet Gy. 2015;122:983–992. doi:10.1111/1471-0528.13249.
  • Fleet J, Jones M, Belan I. Subcutaneous administration of fentanyl in childbirth: an observational study on the clinical effectiveness of fentanyl for mother and neonate. Midwifery. 2014;30:36–42. doi:10.1016/j.midw.2013.01.014.
  • Fleet JA, Jones M, Belan I. Taking the alternative route: Women's experience of intranasal fentanyl, subcutaneous fentanyl or intramuscular pethidine for labour analgesia. Midwifery. 2017;53:15–19. doi:10.1016/j.midw.2017.07.006.
  • Jabalameli M, Talakoub R, Abedi B, Ghofrani Z. A randomized controlled trial comparing the effect of intravenous, subcutaneous, and intranasal fentanyl for pain management in patients undergoing cesarean section. Adv Biomed Res. 2016;5:198. doi:10.4103/2277-9175.190989.
  • Bowie MW, Slattum PW. Pharmacodynamics in older adults: a review. Am J Geriatr Pharmacother. 2007;5:263–303. doi:10.1016/j.amjopharm.2007.10.001.
  • Prostran M, Vujovic KS, Vuckovic S, Medic B, Srebro D, Divac N, Stojanović R, Vujović A, Jovanović L, Jotić A, et al. Pharmacotherapy of pain in the older population: the place of opioids. Front Aging Neurosci. 2016;8:144. doi:10.3389/fnagi.2016.00144.
  • Enright PL, McBurnie MA, Bittner V, Tracy RP, McNamara R, Arnold A, Newman AB. Cardiovascular health study. The 6-min walk test: a quick measure of functional status in elderly adults. Chest. 2003;123:387–398. doi:10.1378/chest.123.2.387.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.