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Journal of Environmental Science and Health, Part A
Toxic/Hazardous Substances and Environmental Engineering
Volume 45, 2010 - Issue 3
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ARTICLES

In vitro study on the effects of lead and mercury on porcine ovarian granulosa cells

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Pages 320-331 | Received 13 Jul 2009, Published online: 28 Jan 2010

References

  • Nampoothiri , L. P. and Gupta , S. 2006 . Simultaneous effect of lead and cadmium on granulosa cells: a cellular model for ovarian toxicity . Reproduct. Toxicol. , 21 : 179 – 185 .
  • Silberstein , T. , Saphier , O. , Paz-Tal , O. , Trimarchi , J. R. , Gonzalez , L. and Keefe , D. L. 2006 . Lead concentrates in ovarian follicle compromises pregnancy . J. Trace Elem. Med. Biol. , 20 : 205 – 207 .
  • Priya , P. N. , Pillai , A. and Gupta , S. 2004 . Effect of simultaneous exposure to lead and cadmium on gonadotropin binding and steroidogenesis on granulosa cells: an in vitro study . Ind. J. Exp Biol. , 42 : 143 – 148 .
  • Schuurs , A. H. 1998 . Working with mercury: cause of infertility in women? Ned . Tijdschr. Tandheelkd. , 105 : 401 – 403 .
  • Shan , G. , Tang , T. and Zhang , X. 2009 . The protective effect of ascorbic acid and thiamine supplementation against damage caused by lead in the testes of mice . J. Huazhong University of Science and Technology Medical Sciences , 29 : 68 – 72 .
  • Zhuang , P. , Zou , B. , Li , N. Y. and Li , Z. A. 2009 . Heavy metal contamination in soils and food crops around Dabaoshan mine in Guangdong, China: implication for human health Environmental Geochemistry and Health Feb 13 [Epub ahead of print]
  • Chrastný , V. , Komárek , M. and Hájek , T. 2009 . Lead contamination of an agricultural soil in the vicinity of a shooting range . Environ. Monit. Assess. , Feb 20 [Epub ahead of print]
  • Fortoul , T. I. , Salgado , C. R. , Moncada , S. G. , Sanchez , I. G. , Lopez , I. E. and Espejel , G. 1999 . Ultrastructural findings in the murine nonciliated bronchiolar cells (NCBC) after subacute inhalation of lead acetate . Acta Veterinaria Brno. , 68 : 51 – 55 .
  • Nampoothiri , L. P. and Gupta , S. 2006 . Simultaneous effect of lead and cadmium on granulosa cells: a cellular model for ovarian toxicity . Reproduc. Toxicol. , 21 : 179 – 185 .
  • Bires , J. , Maracek , I. , Bartko , P. , Biresova , M. and Weissova , T. 1995 . Accumulation of trace elements in sheep and the effects upon qualitative and quantitative ovarian changes . Veter. Human Toxicol. , 37 : 349 – 356 .
  • Kolesarova , A. , Slamecka , J. , Jurcik , R. , Tataruch , F. , Lukac , N. , Kovacik , J. , Capcarova , M. , Valent , M. and Massanyi , P. 2008 . Environmental levels of cadmium, lead and mercury in brown hares and their relation to blood metabolic parameters . J. Environ. Sci. Health, Part A , 43 : 646 – 650 .
  • López-Alonso , M. , Miranda , M. , Castillo , C. , Hernández , J. , García-Vaquero , M. and Benedito , J. L. 2007 . Toxic and essential metals in liver, kidney and muscle of pigs at slaughter in Galicia, north-west Spain . Food Addit. Contam. , 24 : 943 – 954 .
  • Jancova , A. , Massanyi , P. , Nad , P. , Korenekova , B. , Skalicka , M. , Drabekova , J. and Balaz , I. 2006 . Accumulation of heavy metals in selected organs of yellow-necked mouse (Apodemus flavicollis) . Ekologia (Bratislava) , 25 : 19 – 26 .
  • Celechovska , O. , Literak , I. , Ondrus , S. and Pospisil , Z. 2006 . Heavy metals in brown bears from the central European Carpathians . Acta Veterinaria Brno , 75 : 501 – 506 .
  • Myslek , P. and Kalisinska , E. 2006 . Contents of selected heavy metals in the liver, kidneys and abdominal muscle of the brown hare (Lepus europaeus Pallas, 1778) in Central Pomerania, Polish J . Veter. Sci. , 9 : 31 – 41 .
  • Kramarova , M. , Massányi , P. , Slamecka , J. , Tataruch , F. , Jancová , A. , Gasparik , J. , Fabis , M. , Kovacik , J. , Toman , R. , Galová , J. and Jurcik , R. 2005 . Distribution of cadmium and lead in liver and kidney of some wild animals in Slovakia . J. Environ. Sci. Health Pt. A , 40 : 593 – 600 .
  • El-Safty , I. A. M. , Afifi , A. M. H. , Shouman , A. E. and El-Sady , A. K. R. 2004 . Effects of smoking and lead exposure on proximal tubular integrity among Egyptian industrial workers . Arch. Med. Res. , 35 : 59 – 65 .
  • Massanyi , P. , Tataruch , F. , Slamecka , J. , Toman , R. and Jurcik , R. 2003 . Accumulation of lead, cadmium, and mercury in liver and kidney of the brown hare (Lepus europaeus) in relation to the season, age, and sex in the west Slovakian lowland . J. Environ. Sci. Health Pt. A , 38 : 1299 – 1309 .
  • Massanyi , P. , Lukac , N. , Makarevich , A. V. , Chrenek , P. , Forgacs , Z. , Zakrzewski , M. , Stawarz , R. , Toman , R. , Lazor , P. and Flesarova , S. 2007a . Lead-induced alterations in rat kidneys and testes in vivo . J. Environ. Sci. Health Pt. A , 42 : 671 – 676 .
  • Slivkova , J. , Popelkova , M. , Massanyi , P. , Toporcerova , S. , Stawarz , R. , Formicki , G. , Lukac , N. , Putała , A. and Guzik , M. 2009 . Concentration of trace elements in human semen and relation to spermatozoa quality . J. Environ. Sci. Health Pt. A , 44 : 370 – 375 .
  • Taupeau , C. , Poupon , J. , Nomé , F. and Lefèvre , B. 2001 . Lead accumulation in the mouse ovary after treatment-induced follicular atresia . Reprod. Toxicol. , 15 : 385 – 391 .
  • Dearth , R. K. , Hiney , J. K. , Srivastava , V. , Burdick , S. B. , Bratton , G. R. and Dees , W. L. 2002 . Effects of lead (Pb) exposure during gestation and lactation on female pubertal development in the rat . Reprod. Toxicol. , 16 : 343 – 352 .
  • Battacharayya , M. H. 1983 . Bioavailability of orally administered cadmium and lead to the mother, fetus, and neonate during pregnancy and lactation . Sci. Total Environ. , 28 : 327 – 342 .
  • Borella , P. , Picco , P. and Masellis , G. 1986 . Lead content in abortion material from urban women in early pregnancy . Int. Arch. Occup. Environ. Health , 57 : 93 – 99 .
  • Namihira , D. , Saldivar , N. , Pustilnik , N. , Carreon , G. J. and Salinas , M. E. 1993 . Lead in human blood and milk from nursing women living near a smelter in Mexico city . J. Toxicol. Environ. Health , 388 : 225 – 232 .
  • Hallen , P. I. , Jonsson , S. , Karlsson , M. O. and Oskarsson , A. 1996 . Toxicokinetics of lead in lactating and nonlactating mice . Toxicol. Appl. Pharmacol. , 136 : 342 – 347 .
  • Hallen , P. I. , Jorhem , L. and Oskarsson , A. 1995 . Placental and lactational transfer of lead in rats: a study of the lactational process and effects on offspring . Arch. Toxicol. , 69 : 596 – 602 .
  • Pugach , S. and Clarkson , T. 2009 . Prenatal mercury exposure and postnatal outcome: clinical case report and analysis . Clin. Toxicol. (Phila) , 47 : 366 – 370 .
  • Al-Saleh , I. , Coskun , S. , Mashhour , A. , Shinwari , N. , El-Doush , I. , Billedo , G. , Jaroudi , K. , Al-Shahrani , A. , Al-Kabra , M. and El Din Mohamed , G. 2008 . Exposure to heavy metals (lead, cadmium and mercury) and its effect on the outcome of in-vitro fertilization treatment . Int. J. Hyg. Environ. Health , 211 : 560 – 579 .
  • Anonym . 2008 . Dental amalgam: few proven harmful effects but many ongoing concerns . Prescrire. Int. , 17 : 246 – 250 .
  • Lamperti , A. A. and Printz , R. H. 1973 . Effects of mercuric chloride on the reproductive cycle of the female hamster . Biol. Reprod. , 8 : 378 – 387 .
  • Stringari , J. , Nunes , A. K. , Franco , J. L. , Bohrer , D. , Garcia , S. C. , Dafre , A. L. , Milatovic , D. , Souza , D O , Rocha , J B , Aschner , M and Farina , M . 2008 . Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain . Toxicol. Appl. Pharmacol. , 227 : 147 – 154 .
  • Davis , B. J. , Price , H. C. , O'Connor , R. W. , Fernando , R. , Rowland , A. S. and Morgan , D. L. 2001 . Mercury vapor and female reproductive toxicity . Toxicol. Sci. , 59 : 291 – 296 .
  • Ghaedi , M. , Tavallali , H. , Shokrollahi , A. , Zahedi , M. , Montazerozohori , M. and Soylak , M. 2009 . Flame atomic absorption spectrometric determination of zinc, nickel, iron and lead in different matrixes after solid phase extraction on sodium dodecyl sulfate (SDS)-coated alumina as their bis (2-hydroxyacetophenone)-1, 3-propanediimine chelates . J. Hazard. Mater. , 166 : 1441 – 1448 .
  • Saracoglu , S. , Tuzen , M. and Soylak , M. 2009 . Evaluation of trace element contents of dried apricot samples from Turkey . J. Hazard. Mater. , 167 : 647 – 652 .
  • Mendil , D. , Uluözlü , O. D. , Tüzen , M. and Soylak , M. 2008 . Investigation of the levels of some element in edible oil samples produced in Turkey by atomic absorption spectrometry . J. Hazard. Mater. , 165 : 724 – 728 .
  • Perelló , G. , Martí-Cid , R. , Llobet , J. M. and Domingo , J. L. 2008 . Effects of various cooking processes on the concentrations of arsenic, cadmium, mercury, and lead in foods . J. Agric. Food Chem. , 56 : 11262 – 11269 .
  • Budacova , A. , Sirotkin , A. , Kramarova , M. , Kovacik , J. , Florkovicova , I. and Sanislo , P. 2001 . Changes in function and responses of porcine ovarian granulosa cells during sexual maturation . Reproduct. Abstract Ser. , 27 : 14
  • Sirotkin , A. V. , Makarevich , A. V. , Kwon , H. B. , Kotwica , J. , Bulla , J. , Hetenyi , L. and Do , G H . 2001 . IGF-I and oxytocin interact by regulating the secretory activity of porcine ovarian cells? . J. Endocrinol. , 171 : 475 – 480 .
  • Sirotkin , A. V. , Rafay , J. , Kotwica , J. , Darlak , K. and Valenzuela , F. 2009 . Role of ghrelin in regulating rabbit ovarian function and the response to LH and IGF-I . Domestic Animal Endocrinol. , 36 : 162 – 172 .
  • Karamouti , M. , Kollia , P. , Kallitsaris , A. , Vamvakopoulos , N. , Kollios , G. and Messinis , I. E. 2007 . Growth hormone, insulin-like growth factor I, and leptin interaction in human cultured lutein granulosa cells steroidogenesis . Fertility and Sterility , 90 : 1444 – 1450 .
  • Kwintkiewicz , J. and Giudice , L. C. 2009 . The interplay of insulin-like growth factors, gonadotropins, and endocrine disruptors in ovarian follicular development and function . Seminars in Reproductive Medicine , 27 : 43 – 51 .
  • Silva , J. R. , Figueiredo , J. R. and van den Hurk , R. 2009 . Involvement of growth hormone (GH) and insulin-like growth factor (IGF) system in ovarian folliculogenesis . Theriogenology , 71 : 1193 – 1208 .
  • Lucy , M. C. 2008 . Functional differences in the growth hormone and insulin-like growth factor axis in cattle and pigs: implications for post-partum nutrition and reproduction . Reproduction in Domestic Animals , 43 : 31 – 39 .
  • Mao , J. , Smith , M. F. , Rucker , E. B. , Wu , G. M. , McCauley , T. C. , Cantley , T. C. , Prather , R. S. , Didion , B. A. and Day , B. N. 2004 . Effect of epidermal growth factor and insulin-like growth factor I on porcine preantral follicular growth, antrum formation, and stimulation of granulosal cell proliferation and suppression of apoptosis in vitro . J. Anim. Sci. , 82 : 1967 – 1975 .
  • Ortega , H. H. , Palomar , M. M. , Acosta , J. C. , Salvetti , N. R. , Dallard , B. E. , Lorente , J. A. , Barbeito , C. G. and Gimeno , E. J. 2008 . Insulin-like growth factor I in sera, ovarian follicles and follicular fluid of cows with spontaneous or induced cystic ovarian disease . Res. Veter. Sci. , 84 : 419 – 427 .
  • Sirotkin , A. V. , Benco , A. , Tandlmajerova , A. , Vasícek , D. , Kotwica , J. , Darlak , K. and Valenzuela , F. 2008a . Transcription factor p53 can regulate proliferation, apoptosis and secretory activity of luteinizing porcine ovarian granulosa cell cultured with and without ghrelin and FSH . Reproduction , 136 : 611 – 618 .
  • Sirotkin , A. V. , Grossmann , R. , María-Peon , M. T. , Roa , J. , Tena-Sempere , M. and Klein , S. 2006 . Novel expression and functional role of ghrelin in chicken ovary . Molecular and Cellular Endocrinology , 257–258 : 15 – 25 .
  • Hagan , C. R. , Faivre , E. J. and Lange , C. A. 2008 . Scaffolding actions of membrane-associated progesterone receptors . Steroids , 74 : 568 – 572 .
  • Arnhold , I. J. , Lofrano-Porto , A. and Latronico , A. C. 2009 . Inactivating mutations of luteinizing hormone beta-subunit or luteinizing hormone receptor cause oligo-amenorrhea and infertility in women . Hormone Res. , 71 : 75 – 82 .
  • Mészárosová , M. , Sirotkin , A. V. , Grossmann , R. , Darlak , K. and Valenzuela , F. 2008 . The effect of obestatin on porcine ovarian granulosa cells . Animal Reprod. Sci. , 108 : 196 – 207 .
  • Massany , P. , Uhrin , V. , Sirotkin , A. , Paksy , K. , Forgacs , Zs. , Toman , R. and Kovacik , J. 2000 . Effect of cadmium on ultrastructure and steroidogenesis in cultured porcine ovarian granulosa cells . Acta Veterinaria Brno , 69 : 101 – 106 .
  • Mahajan , D. K. 2008 . “ Pig Model to study dynamics of steroids during ovarian follicular growth and maturation ” . In Sourcebook of Models for Biomedical Research , 425 – 436 . Humana Press . ISBN 978-1-58829-933-8
  • Skarzynski , D. J. , Siemieniuch , M. J. , Pilawski , W. , Woclawek Potocka , I. , Bah , M. M. , Majewska , M. and Jaroszewski , J. J. 2008 . In Vitro assessment of progesterone and prostaglandin E(2) production by the corpus luteum in cattle following pharmacological synchronization of estrus . J. Reprod. Develop. , 55 : 170 – 176 .
  • Sirotkin , A. V. , Mlyncek , M. , Makarevich , A. V. , Florkovicová , I. and Hetényi , L. 2008b . Leptin affects proliferation-, apoptosis- and protein kinase A-related peptides in human ovarian granulosa cells . Physiol. Res. , 57 : 437 – 442 .
  • Wyllie , A. , Donahue , M. S. , Fischer , B. , Hill , D. , Keesey , J. and Manzow , S. 1998 . Apoptosis and Cell Proliferation, , edn 2 , Vol. 1–5 , 64 – 66 . Mannheim : Boehringer .
  • Rak , A. and Gregoraszczuk , E. L. 2008 . Modulatory effect of ghrelin in prepubertal porcine ovarian follicles . J. Physiol. Pharmacol. , 59 : 781 – 793 .
  • Cheng , Y. , Maeda , A. , Goto , Y. , Matsuda , F. , Miyano , T. , Inoue , N. , Sakamaki , K. and Manabe , N. 2008 . Changes in expression and localization of X-linked inhibitor of apoptosis protein (XIAP) in follicular granulosa cells during atresia in porcine ovaries . J. Reprod. Develop. , 54 : 454 – 459 .
  • Moon , H. J. , Seok , J. H. , Kim , S. S. , Rhee , G. S. , Lee , R. D. , Yang , J. Y. , Chae , S. Y. , Kim , S. H. , Kim , J. Y. , Chung , J. Y. , Kim , J. M. and Chung , S. Y. 2009 . Lactational coumestrol exposure increases ovarian apoptosis in adult rats . Arch. Toxicol. , Jan 23 [Epub ahead of print]
  • Zhang , W. , Huang , L. , Zhuang , Y. and Wang , W. 2008 . The effect of mifepristone on apoptosis and caspase-3 activation in human ovarian luteinized granulosa cells . Euro. J. Obstet. Gynecol. Reproduct. Biol. , 141 : 131 – 136 .
  • Makarevich , A. V. and Sirotkin , A. V. 1999 . Development of sensitive radioimmunoassay for IGF-I determination in samples from blood plasma and cell-conditioned medium . Veter. Med. , 44 : 71 – 78 .
  • Osborn , M. and Isenberg , S. 1994 . “ Immunocytochemistry of frozen and of paraffin tissue sections ” . In Cell Biology: A Laboratory Hanbook , 361 – 367 . New York/London : Academic Press .
  • Massányi , P. , Lukác , N. , Uhrín , V. , Toman , R. , Pivko , J. , Rafay , J. , Forgács , Z. and Somosy , Z. 2007b . Female reproductive toxicology of cadmium . Acta Biologica Hungarica , 58 : 287 – 299 .
  • Almášiová , V. , Cigánková , V. , Holovská , K. , Lenhardt , L. , Škrobánek , P. , Massányi , P. and Zibrín , M. 2008 . Effect of Hypodynamy on Structure and Alkaline Phosphatase Activity of Kidney in Japanese Quails . Acta Veterinaria Brno , 77 : 313 – 320 .
  • Paksy , K. , Rajczy , K. , Forgács , Z. , Lázár , P. , Bernard , A. , Gáti , I. and Kaáli , G. S. 1997 . Effect of cadmium on morphology and steroidogenesis of cultured human ovarian granulosa cells . J. Appl. Toxicol. , 17 : 321 – 327 .
  • Paksy , K. , Gáti , I. , Náray , M. and Rajczy , K. 2001 . Lead accumulation in human ovarian follicular fluid, and in vitro effect of lead on progesterone production by cultured human ovarian granulosa cells . J. Toxicol. Environ. Health Pt. A , 62 : 359 – 366 .
  • Pine , M. D. , Hiney , J. K. , Dearth , R. K. , Bratton , G. R. and Dees , W. L. 2006 . IGF-1 administration to prepubertal female rats can overcome delayed puberty caused by maternal Pb exposure . Reproduc. Toxicol. , 21 : 104 – 109 .
  • Iavicoli , I. , Carelli , G. , Stanek , E. J. 3rd , Castellino , N. and Calabrese , E. J. 2004 . Effects of low doses of dietary lead on puberty onset in female mice . Reproduc. Toxicol. , 19 : 35 – 41 .
  • Davis , B. J. , Price , H. C. , O'Connor , R. W. , Fernando , R. , Rowland , A. S. and Morgan , D. L. 2001 . Mercury vapor and female reproductive toxicity . Toxicol. Sci. , 59 : 291 – 296 .
  • Lamperti , A. A. and Printz , R. H. 1973 . Effects of mercuric chloride on the reproductive cycle of the female hamster . Biol. Reprod. , 8 : 378 – 387 .
  • Mondal , S. , Mukhopadhyay , B. and Bhattacharya , S. 1997 . Inorganic mercury binding to fish oocyte plasma membrane induces steroidogenesis and translatable messenger RNA synthesis . Biometals , 10 : 285 – 290 .
  • Madej , A. , Lang , A. , Brandt , Y. , Kindahl , H. , Madsen , M. T. and Einarsson , S. 2005 . Factors regulating ovarian function in pigs . Domest. Anim. Endocrinol. , 29 : 347 – 361 .
  • Sirotkin , A. V. , Chrenek , P. , Darlak , K. , Valenzuela , F. and Kuklová , Z. 2008 . Some endocrine traits of transgenic rabbits . II. Changes in hormone secretion and response of isolated ovarian tissue to FSH and ghrelin. Physiol Res. , 57 : 745 – 751 .
  • Jiang , J. Y. , Cheung , C. K. , Wang , Y. and Tsang , B. K. 2003 . Regulation of cell death and cell survival gene expression during ovarian follicular development and atresia . Frontiers in Bioscience , 8 : d222 – 237 .
  • Vogetseder , A. , Picard , N. , Gaspert , A. , Walch , M. , Kaissling , B. and Le Hir , M. 2008 . Proliferation capacity of the renal proximal tubule involves the bulk of differentiated epithelial cells . Amer. J. Physiol. , 294C : 22 – 28 .
  • Vaskivuo , T. E. and Tapanainen , J. S. 2003 . Apoptosis in the human ovary . Reproduct. Biomed. Online , 6 : 24 – 35 .
  • Kim , J. M. , Boone , D. L. , Auyeung , A. and Tsang , B. K. 1998 . Granulosa cell apoptosis induced at the penultimate stage of follicular development is associated with increased levels of Fas and Fas ligand in the rat ovary . Biol. Reprod. , 58 : 1170 – 1176 .
  • Rolaki , A. , Drakakis , P. , Millingos , S. , Loutradis , D. and Makrigiannakis , A. 2005 . Novel trends in follicular development, atresia and corpus luteum regression: a role for apoptosis . Reproduct. Biomed. Online , 11 : 93 – 103 .
  • Agarwal , S. , Kumar , R. , Gupta , P. and Dixit , A. 2008 . Identification and characterization of a positive regulatory cis-element within the upstream region of c-jun . J. Biochem. , 144 : 741 – 752 .
  • Gorbel , F. , Boujelbene , M. , Makni-Ayadi , F. , Guermazi , F. , Croute , F. , Soleilhavoup , J. P. and el Feki , A. 2002 . Cytotoxic effects of lead on the endocrine and exocrine sexual function of pubescent male and female rats . Demonstration of apoptotic activity. Comp. Rend. Biol. , 325 : 927 – 940 .
  • Xu , J. , Ji , L. D. and Xu , L. H. 2006 . Lead-induced apoptosis in PC 12 cells: Involvement of p53, Bcl-2 family and caspase-3 . Toxicol. Lett. , 166 : 160 – 167 .

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