The cytological effects of HBCDs on human hepatocyte L02 and the potential molecular mechanism

References

• Arnot , J. A. , Armitage , J. M. , McCarty , L. S. , Wania , F. , Cousins , I. T. and Toose-Reid , L. 2011 . Toward a consistent evaluative framework for POP risk characterization . Environ. Sci. Technol. , 45 ( 1 ) : 97 – 103 .
   PubMed Web of Science ®Google Scholar
• Janak , K. , Cavaci , A. , Voorspoels , S. and Becher , G. 2005 . Hexabromocyclododecane in marine species from the western Scheldt estuary: Disastereoismer- and enantiomer-specific accumulation . Environ. Sci. Technol. , 39 : 1987 – 1994 .
   PubMed Web of Science ®Google Scholar
• Marvin , C. H. , Tomy , G. T. , Armitage , J. M. , Arnot , J. A. , McCarty , L. , Covaci , A. and Palace , V. 2011 . Hexabromocyclododecane: current understanding of chemistry, environmental fate and toxicology and implications for global management . Environ. Sci. Technol. , 45 ( 20 ) : 8613 – 8623 .
   PubMed Web of Science ®Google Scholar
• Jiang , Y. Q. 2007 . Current situation and development of bromine retardant worldwide. Chin . J. Flame. Retardant. Mater. Technol. , 2 : 1 – 7 . in Chinese
   Google Scholar
• Covaci , A. , Gerecke , A. C. , Law , R. J. , Voorspoels , S. , Kohler , M. , Heeb , N. V. , Leslie , H. , Allchin , C. R. and de Boer , J. 2006 . Hexabromocyclododecanes (HBCDs) in the environment and humans: A review . Environ. Sci. Technol. , 40 ( 12 ) : 3679 – 3688 .
   PubMed Web of Science ®Google Scholar
• Gao , S. , Wang , J. , Yu , Z. , Guo , Q. , Sheng , G. and Fu , J. 2011 . Hexabromocyclododecanes in surface soils from E-waste recycling areas and industrial areas in south China: concentrations, diastereoisomer- and enantiomer-specific profiles, and inventory . Environ. Sci. Technol. , 45 ( 6 ) : 2093 – 2099 .
   PubMed Web of Science ®Google Scholar
• Hermanson , M. H. , Isaksson , E. , Forsstrom , S. , Texeira , C. , Muir , D. C.G. , Pohjola , V. A. and van de Wal , R. S.V. 2010 . Deposition history of brominated flame retardant compounds in an ice core from Holtedahlfonna, Svalbard, Norway . Environ. Sci. Technol. , 44 ( 19 ) : 7405 – 7410 .
   PubMed Web of Science ®Google Scholar
• Xia , C. , Lam , J. C.W. , Wu , X. , Sun , L. , Xie , Z. and Lam , P. K.S. 2011 . Hexabromocyclododecanes (HBCDs) in marine fishes along the Chinese coastline . Chemosphere. , 82 ( 11 ) : 1662 – 1668 .
   PubMed Web of Science ®Google Scholar
• Morris , S. , Allchin , C. R. , Zegers , B. N. , Haftka , J. J.H. , Boon , J. P. , Belpaire , C. , Leonards , P. E.G. , Van Leeuwen , S. P.J. and De Boer , J. 2004 . Distributon and fate of HBCD and TBBPA brominated flame retardants in north sea estuaries and aquatic food webs . Environ. Sci. Technol. , 38 ( 21 ) : 5497 – 5504 .
   PubMed Web of Science ®Google Scholar
• Stapleton , H. M. , Dodder , N. G. , Kucklick , J. R. , Reddy , C. M. , Schantz , M. M. , Becker , P. R. , Gulland , F. , Porter , B. J. and Wise , S. A. 2006 . Determination of HBCD, PBDEs and MeO-BDEs in California sea lions (Zalophus californianus) stranded between 1993 and 2003 . Mar. Pollut. Bull. , 52 ( 5 ) : 522 – 531 .
   PubMed Web of Science ®Google Scholar
• Toms , L. M.L. , Guerra , P. , Eljarrat , E. , Barcelo , D. , Harden , F. A. , Hobson , P. , Sjodin , A. , Ryan , E. and Mueller , J. F. 2012 . Brominated flame retardants in the Australian population:1993–2009 . Chemosphere , 89 ( 4 ) : 398 – 403 .
   PubMed Web of Science ®Google Scholar
• Aylward , L. L. and Hays , S. M. 2011 . Biomonitoring-based risk assessment for hexabromocyclododecane (HBCD). Int . J. Hyg. Environ. Health , 214 ( 3 ) : 179 – 187 .
   PubMed Web of Science ®Google Scholar
• Shi , Z. X. , Wu , Y. N. , Li , J. G. , Zhao , Y. F. and Feng , J. F. 2009 . Dietary exposure assessment of Chinese adults and nursing infants to tetrabromobisphenol-A and hexabromocyclododecanes: occurrence measurements in foods and human milk . Environ. Sci. Technol , 43 ( 12 ) : 4314 – 4319 .
   PubMed Web of Science ®Google Scholar
• van der Ven , L. T.M. , Verhoef , A. , van de Kuil , T. , Slob , W. , Leonards , P. E.G. , Visser , T. J. , Hamers , T. , Herlin , M. , Hakansson , H. , Olausson , H. , Piersma , A. H. and Vos , J. G. 2006 . A 28-day oral dose toxicity study enhanced to detect endocrine effects of hexabromocyclododecane in wistar rats . Toxicol. Sci. , 94 ( 2 ) : 281 – 292 .
   PubMed Web of Science ®Google Scholar
• KEMI . 2002 . Risk Assessment Hexabromocyclododecane , Sweden : National Chemicals Inspectorate .
   Google Scholar
• Villanger , G. D. , Lydersen , C. , Kovacs , K. M. , Lie , E. , Skaare , J. U. and Jenssen , B. M. 2011 . Disruptive effects of persistent organohalogen contaminants on thyroid function in white whales (Delphinapterus leucas) from Svalbard . Sci. Total Environ. , 409 ( 13 ) : 2511 – 2524 .
   PubMed Web of Science ®Google Scholar
• Hinkson , N. C. and Whalen , M. M. 2010 . Hexabromocyclododecane decreases tumor-cell-binding capacity and cell-surface protein expression of human natural killer cells . J. Appl. Toxicol. , 30 ( 4 ) : 302 – 309 .
   PubMed Web of Science ®Google Scholar
• van der Ven , L. T.M. , van de Kuil , T. , Leonards , P. E.G. , Slob , W. , Lilienthal , H. , Litens , S. , Herlin , M. , Hakansson , H. , Canton , R. F. , van den Berg , M. , Visser , T. J. , van Loveren , H. , Vos , J. G. and Piersma , A. H. 2009 . Endocrine effects of hexabromocyclododecane (HBCD) in a one-generation reproduction study in Wistar rats . Toxicol. Lett. , 185 ( 1 ) : 51 – 62 .
   PubMed Web of Science ®Google Scholar
• Eriksson , P. , Fischer , C. , Wallin , M. , Jakobsson , E. and Fredriksson , A. 2006 . Impaired behaviour, learning and memory, in adult mice neonatally exposed to hexabromocyclododecane (HBCDD) . Environ. Toxicol. Pharmacol. , 21 ( 3 ) : 317 – 322 .
   PubMed Web of Science ®Google Scholar
• Lilienthal , H. , van der Ven , L. T.M. , Piersma , A. H. and Vos , J. G. 2009 . Effects of the brominated flame retardant hexabromocyclododecane (HBCD) on dopamine-dependent behavior and brainstem auditory evoked potentials in a one-generation reproduction study in Wistar rats . Toxicol. Lett. , 185 ( 1 ) : 63 – 72 .
   PubMed Web of Science ®Google Scholar
• KEMI . 2005 . Draft of the EU Risk Assessment Report on Hexabromocyclododecane , Sweden : National Chemicals Inspectorate: Sundbyberg .
   Google Scholar
• United Nations Environment Programme . 2011 . Risk management evaluation on hexabromocyclododecane . Seventh meeting of the Stockholm Convention's Persistant Organic Pollutants Review Committee . 10–14 Oct 2011 , Geneva , Switzerland. Available at http://chm.pops.int/Convention/POPsReviewCommittee/POPRCMeetings/POPRC7/POPRC7ReportandDecisions/tabid/2472/Default.aspx
   Google Scholar
• US EPA . 2010 . Hexabromocyclododecane (HBCD) action plan. U.S. Environmental Protection Agency . : 12 Available at http://www.epa.gov/oppt/existingchemicals/pubs/actionplans/RIN2070-AZ10_HBCD%20action%20plan_Final_2010–08–09.pdf (accessed June 2011)
   Google Scholar
• Hu , J. , Liang , Y. , Chen , M. and Wang , X. 2009 . Assessing the toxicity of TBBPA and HBCD by zebrafish embryo toxicity assay and biomarker analysis . Environ. Toxicol. , 24 ( 4 ) : 334 – 342 .
   PubMed Web of Science ®Google Scholar
• Aniagu , S. O. , Williams , T. D. and Chipman , J. K. 2009 . Changes in gene expression and assessment of DNA methylation in primary human hepatocytes and HepG2 cells exposed to the environmental contaminants—Hexabromocyclododecane and 17-β oestradiol . Toxicology , 256 ( 3 ) : 143 – 151 .
   PubMed Web of Science ®Google Scholar
• Ibhazehiebo , K. , Iwasaki , T. , Shimokawa , N. and Koibuchi , N. 2011 . 1,2,5,6,9,10-alpha hexabromocyclododecane (HBCD) impairs thyroid hormone-induced dendrite arborization of purkinje cells and suppresses thyroid hormone receptor-mediated transcription . Cerebellum , 10 ( 1 ) : 22 – 31 .
   PubMed Web of Science ®Google Scholar
• Palace , V. P. , Pleskach , K. , Halldorson , T. , Danell , R. , Wautier , K. , Evans , B. , Alaee , M. , Marvin , C. and Tomy , G. T. 2008 . Biotransformation enzymes and thyroid axis disruption in juvenile rainbow trout (Oncorhynchus mykiss) exposed to hexabromocyclododecane diastereoisomers . Environ. Sci. Technol. , 42 ( 6 ) : 1967 – 1972 .
   PubMed Web of Science ®Google Scholar
• Anselmo , H. M.R. , Koerting , L. , Devito , S. , van den Berg , J. H.J. , Dubbeldam , M. , Kwadijk , C. and Murk , A. J. 2011 . Early life developmental effects of marine persistent organic pollutants on the sea urchin Psammechinus miliaris . Ecotoxicol. Environ. Saf. , 74 ( 8 ) : 2182 – 2192 .
   PubMed Web of Science ®Google Scholar
• Du , M. , Zhang , D. , Yan , C. and Zhang , X. 2012 . Developmental toxicity evaluation of three hexabromocyclododecane diastereoisomers on zebrafish embryos . Aquat. Toxicol. , 112 : 1 – 10 .
   PubMed Web of Science ®Google Scholar
• Deng , J. , Yu , L. , Liu , C. , Yu , K. , Shi , X. , Yeung , L. W.Y. , Lam , P. K.S. , Wu , R. S.S. and Zhou , B. 2009 . Hexabromocyclododecane-induced developmental toxicity and apoptosis in zebrafish embryos . Aquat. Toxicol , 93 ( 1 ) : 29 – 36 .
   PubMed Web of Science ®Google Scholar
• Zhang , X. , Yang , F. , Zhang , X. , Xu , Y. , Liao , T. , Song , S. and Wang , H. 2008 . Induction of hepatic enzymes and oxidative stress in Chinese rare minnow (Gobiocypris rarus) exposed to waterborne hexabromocyclododecane (HBCDD) . Aquat. Toxicol. , 86 ( 1 ) : 4 – 11 .
   PubMed Web of Science ®Google Scholar
• Nishizawa , C. , Hashimoto , N. , Yokoo , S. , Funakoshi-Tago , M. , Kasahara , T. , Takahashi , K. , Nakamura , S. and Mashino , T. 2009 . Pyrrolidinium-type fullerene derivative-induced apoptosis by the generation of reactive oxygen species in HL-60 cells . Free Radical Res. , 43 ( 12 ) : 1240 – 1247 .
   PubMed Web of Science ®Google Scholar
• Al-Mousa , F. and Michelangeli , F. 2012 . Some commonly used brominated flame retardants cause Ca2+-ATPase inhibition, beta-amyloid peptide release and apoptosis in SH-SY5Y neuronal cells . PloS one. , 7 ( 4 ) : e33059 – e33059 .
   PubMed Web of Science ®Google Scholar
• Balaban , R. S. , Nemoto , S. and Finkel , T. 2005 . Mitochondria, oxidants, and aging . Cell , 120 ( 4 ) : 483 – 495 .
   PubMed Web of Science ®Google Scholar
• Green , D. R. and Kroemer , G. 2004 . The pathophysiology of mitochondrial cell death . Science , 305 ( 5684 ) : 626 – 629 .
   PubMed Web of Science ®Google Scholar