Year-long and seasonal differences of PM_2.5 chemical characteristics and their role in the viability of human lung epithelial cells (A549)

References

• Liu, K.; Ren, J. Seasonal Characteristics of PM2.5 and Its Chemical Species in the Northern Rural China. Atmos. Pollut. Res. 2020, 11, 1891–1901. DOI: 10.1016/j.apr.2020.08.005.
   Web of Science ®Google Scholar
• Das, A.; Singh, G.; Habib, G.; Kumar, A. Non-Carcinogenic and Carcinogenic Risk Assessment of Trace Elements of PM2.5 During Winter and Pre-Monsoon Seasons in Delhi: A Case Study. Expo. Health 2020, 12, 63–77. DOI: 10.1007/s12403-018-0285-y.
   Web of Science ®Google Scholar
• Das, A.; Kumar, A.; Habib, G.; Vivekanandan, P. Insights on the Biological Role of Ultrafine Particles of Size PM < 0.25: A Prospective Study from New Delhi. Environ. Pollut. 2021, 268, 115638. DOI: 10.1016/j.envpol.2020.115638.
   PubMed Web of Science ®Google Scholar
• Das, A.; Habib, G.; Vivekanandan, P.; Kumar, A. Reactive Oxygen Species Production and Inflammatory Effects of Ambient PM2.5-Associated Metals on Human Lung Epithelial A549 Cells “One Year-Long Study”: The Delhi Chapter. Chemosphere 2021, 262, 128305. DOI: 10.1016/j.chemosphere.2020.128305.
   PubMed Web of Science ®Google Scholar
• Deng, X.; Rui, W.; Zhang, F.; Ding, W. PM2.5 Induces NRF2-Mediated Defense Mechanisms against Oxidative Stress by Activating PIK3/AKT Signaling Pathway in Human Lung Alveolar Epithelial A549 Cells. Cell Biol. Toxicol. 2013, 29, 143–157. DOI: 10.1007/s10565-013-9242-5.
   PubMed Web of Science ®Google Scholar
• Huang, W.; Pang, Y.; Luo, X. S.; Chen, Q.; Wu, L.; Tang, M.; Hong, Y.; Chen, J.; Jin, L. The Cytotoxicity and Genotoxicity of PM2.5 during a Snowfall Event in Different Functional Areas of a Megacity. Sci. Total Environ. 2020, 741, 140267. DOI: 10.1016/j.scitotenv.2020.140267.
   PubMed Web of Science ®Google Scholar
• Chen, Q.; Luo, X. S.; Chen, Y.; Zhao, Z.; Hong, Y.; Pang, Y.; Huang, W.; Wang, Y.; Jin, L. Seasonally Varied Cytotoxicity of Organic Components in PM2.5 from Urban and İndustrial Areas of a Chinese Megacity. Chemosphere 2019, 230, 424–431. DOI: 10.1016/j.chemosphere.2019.04.226.
   PubMed Web of Science ®Google Scholar
• Chen, X. C.; Chuang, H. C.; Ward, T. J.; Sarkar, C.; Webster, C.; Cao, J.; Hsiao, T. C.; Ho, K. F. Toxicological Effects of Personal Exposure to Fine Particles in Adult Residents of Hong Kong. Environ. Pollut. 2021, 275, 116633. DOI: 10.1016/j.envpol.2021.116633.
   PubMed Web of Science ®Google Scholar
• Chen, X.; Ward, T. J.; Sarkar, C.; Ho, K.-F.; Webster, C. Health Risks of Adults in Hong Kong Related to İnhalation of Particle-Bound Heavy Metal(Loid)s. Air Qual. Atmos. Health 2022, 15, 691–706. DOI: 10.1007/s11869-021-01115-6.
   Web of Science ®Google Scholar
• Kermani, M.; Rahmatinia, T.; Oskoei, V.; et al. Potential Cytotoxicity of Trace Elements and Polycyclic Aromatic Hydrocarbons Bounded to Particulate Matter: A Review on In Vitro Studies on Human Lung Epithelial Cells. Environ. Sci. Pollut. Res. Int. 2021, 28, 55888–55904. DOI: 10.1007/s11356-021-16306-y.
   PubMed Web of Science ®Google Scholar
• Chen, Y.; Wu, Y.; Qi, Y.; Liu, S. Cell Death Pathways: The Variable Mechanisms Underlying Fine Particulate Matter-Induced Cytotoxicity. ACS Nanosci. Au 2023, 3, 130–139. DOI: 10.1021/acsnanoscienceau.2c00059.
   PubMedGoogle Scholar
• Siudek, P. Chemical Composition and Source Apportionment of Ambient PM2.5 in a Coastal Urban Area, Northern Poland. Chemosphere 2024, 356, 141850. DOI: 10.1016/j.chemosphere.2024.141850.
   PubMedGoogle Scholar
• Baysal, A.; Baltaci, H.; Ozbek, N.; Destanoglu, O.; Ustabasi, G. S.; Gumus, G. Chemical Characterization of Surface Snow in Istanbul (NW Turkey) and Their Association with Atmospheric Circulations. Environ. Monit. Assess. 2017, 189, 275. DOI: 10.1007/s10661-017-5982-7.
   PubMed Web of Science ®Google Scholar
• Ozbek, N.; Baltaci, H.; Baysal, A. Investigation of Fluorine Content in PM2.5 Airborne Particles of Istanbul, Turkey. Environ. Sci. Pollut. Res. 2016, 23, 13169–13177. DOI: 10.1007/s11356-016-6506-7.
   PubMed Web of Science ®Google Scholar
• ISO 17586:2016. Soil Quality—Extraction of Trace Elements Using Dilute Nitric Acid, 2016.
   Google Scholar
• Vark, W.; van Harmsen, J. Validation of ISO 17586 Soil Quality; Extraction of Trace Elements Using Dilute Nitric Acid; Alterra Wageningen UR (University & Research Centre), Wageningen, Alterra report 2693, 2015, pp 58.
   Google Scholar
• Gao, D.; Mulholland, J. A.; Russell, A. G.; Weber, R. J. Characterization of Water-Insoluble Oxidative Potential of PM2.5 Using the Dithiothreitol Assay. Atmos. Environ. 2020, 224, 117327. DOI: 10.1016/j.atmosenv.2020.117327.
   Web of Science ®Google Scholar
• Saygin, H.; Soyocak, A.; Baysal, A.; Saridag, A. M. Characterizing the Interaction between Micro(Nano)Plastics and Simulated Body Fluids and Their Impact on Human Lung Epithelial Cells. J. Environ. Sci. Health A Tox. Hazard. Subst. Environ. Eng. 2023, 58, 855–868. DOI: 10.1080/10934529.2023.2243190.
   PubMed Web of Science ®Google Scholar
• Baysal, A.; Soyocak, A.; Saygin, H.; Saridag, A. M. Exposure to Phagolysosomal Simulated Fluid Altered the Cytotoxicity of PET Micro(Nano)Plastics to Human Lung Epithelial Cells. Toxicol. Mech. Methods 2024, 34, 72–97. DOI: 10.1080/15376516.2023.2256847.
   PubMed Web of Science ®Google Scholar
• Akhtar, U. S.; McWhinney, R. D.; Rastogi, N.; Abbatt, J. P.; Evans, G. J.; Scott, J. A. Cytotoxic and Proinflammatory Effects of Ambient and Source-Related Particulate Matter (PM) in Relation to the Production of Reactive Oxygen Species (ROS) and Cytokine Adsorption by Particles. Inhal. Toxicol. 2010, 22 Suppl 2, 37–47. DOI: 10.3109/08958378.2010.518377.
   PubMed Web of Science ®Google Scholar
• Szigeti, T.; Mihucz, V. G.; Óvári, M.; Baysal, A.; Atılgan, S.; Akman, S.; Záray, G. Chemical Characterization of PM2.5 Fractions of Urban Aerosol Collected in Budapest and Istanbul. Microchem. J. 2013, 107, 86–94. DOI: 10.1016/j.microc.2012.05.029.
   Web of Science ®Google Scholar
• Atilgan, S.; Akman, S.; Baysal, A.; Bakircioglu, Y.; Szigeti, T.; Óvári, M.; Záray, G. Monitoring of Pd in Airborne Particulates by Solid Sampling High-Resolution Continuum Source Electrothermal Atomic Absorption Spectrometry. Spectrochim. Acta Part B At. Spectrosc. 2012, 70, 33–38. DOI: 10.1016/j.sab.2012.04.008.
   Web of Science ®Google Scholar
• WHO. Air Quality Guidelines for Europe, 2nd ed.; WHO Regional Publications, European Series, No. 91; Regional Office for Europe: Copenhagen, 2000.
   Google Scholar
• USEPA. National Ambient Air Quality Standards for Particulate Matter, Part KK. Federal Register, 62, No. 138, July 18, 1997, Rules and Regulations, 1997.
   Google Scholar
• European Union. Council Directive 1999/30/EC Relating to Limit Values for Sulphur Dioxide, Nitrogen Dioxide and Oxides of Nitrogen, Articulate Matter and Lead in Ambient Air, 1999.
   Google Scholar
• Union, E. Council Directive 2004/107/EC Relating to Arsenic, Cadmium, Mercury, Nickel and Polycyclic Aromatic Hydrocarbons in Ambient Air. Off. J. 2004, L23, 3.
   Google Scholar
• Onat, B.; Sahin, U. A.; Akyuz, T. Elemental Characterization of PM2.5 and PM1 in Dense Traffic Area in Istanbul, Turkey. Atmos. Pollut. Res. 2013, 4, 101–105. DOI: 10.5094/APR.2013.010.
   Web of Science ®Google Scholar
• Haswani, D.; Sunder Raman, R.; Yadav, K.; et al. Pollution Characteristics and Ecological Risks of Trace Elements in PM2.5 over Three COALESCE Network Sites – Bhopal, Mesra, and Mysuru, India. Chemosphere 2023, 324, 138203. DOI: 10.1016/j.chemosphere.2023.138203.
   PubMed Web of Science ®Google Scholar
• Martínez Morales, S.; Cerón Bretón, J. G.; Carbajal, N.; Cerón Bretón, R. M.; Lara Severino, R.; Kahl, J. D. W.; Carrillo Ávila, J. R.; Carranco Lozada, S. E.; Espinosa Guzmán, A.; Pech Pech, I. E.; et al. PM2.5-Bound Trace Metals in an Urban Area of Northern Mexico during the COVID-19 Pandemic: Characterization, Sources, and Health Risk. Air Qual. Atmos. Health 2023, 16, 1789–1808. DOI: 10.1007/s11869-023-01372-7.
   Web of Science ®Google Scholar
• Soleimani, M.; Amini, N.; Sadeghian, B.; Wang, D.; Fang, L. Heavy Metals and Their Source İdentification in Particulate Matter (PM2.5) in Isfahan City, Iran. J. Environ. Sci. 2018, 72, 166–175. DOI: 10.1016/j.jes.2018.01.002.
   Google Scholar
• Banerjee, T.; Murari, V.; Kumar, M.; Raju, M. P. Source Apportionment of Airborne Particulates through Receptor Modeling: Indian Scenario. Atmos. Res. 2015, 164–165, 167–187. DOI: 10.1016/j.atmosres.2015.04.017.
   Web of Science ®Google Scholar
• Butterfield, D. M.; Brown, R. J.; Brown, A. S. Seasonality of Heavy Metal Concentrations in Ambient Particulate Matter in the UK. Atmosphere 2024, 15, 636. DOI: 10.3390/atmos15060636.
   Web of Science ®Google Scholar
• Usman, F.; Zeb, B.; Alam, K.; Huang, Z.; Shah, A.; Ahmad, I.; Ullah, S. In-Depth Analysis of Physicochemical Properties of Particulate Matter (PM10, PM2.5 and PM1) and Its Characterization through FTIR, XRD and SEM–EDX Techniques in the Foothills of the Hindu Kush Region of Northern Pakistan. Atmosphere 2022, 13, 124. DOI: 10.3390/atmos13010124.
   Web of Science ®Google Scholar
• Wei, X.; Gui, H.; Liu, J.; Zhang, J.; Schwab, J.; Gao, M. Aerosol Pollution Characterization before Chinese New Year in Zhengzhou in 2014. Aerosol Air Qual. Res. 2019, 19, 1294–1306. DOI: 10.4209/aaqr.2018.06.0226.
   Web of Science ®Google Scholar
• Yu, X.; Song, W.; Yu, Q.; Li, S.; Zhu, M.; Zhang, Y.; Deng, W.; Yang, W.; Huang, Z.; Bi, X.; Wang, X. Fast Screening Compositions of PM2.5 by ATR-FTIR: Comparison with Results from IC andOC/EC Analyzers. J. Environ. Sci. 2018, 71, 76–88. DOI: 10.1016/j.jes.2017.11.021.
   Google Scholar
• Gualtieri, M.; Øvrevik, J.; Holme, J. A.; Perrone, M. G.; Bolzacchini, E.; Schwarze, P. E.; Camatini, M. Differences in Cytotoxicity versus Pro-Inflammatory Potency of Different PM Fractions in Human Epithelial Lung Cells. Toxicol. In Vitro 2010, 24, 29–39. DOI: 10.1016/j.tiv.2009.09.013.
   PubMed Web of Science ®Google Scholar
• He, Q.; Yan, Y.; Guo, L.; Zhang, Y.; Zhang, G.; Wang, X. Characterization and Source Analysis of Water-Soluble Inorganic Ionic Species in PM2.5 in Taiyuan City, China. Atmos. Res. 2017, 184, 48–55. DOI: 10.1016/j.atmosres.2016.10.008.
   Web of Science ®Google Scholar
• Lee, S.-J.; Lee, H.-Y.; Kim, S.-J.; Kang, H.-J.; Kim, H.; Seo, Y.-K.; Shin, H.-J.; Ghim, Y. S.; Song, C.-K.; Choi, S.-D. Pollution Characteristics of PM2.5 during High Concentration Periods in Summer and Winter in Ulsan, the Largest Industrial City in South Korea. Atmos. Environ. 2023, 292, 119418. DOI: 10.1016/j.atmosenv.2022.119418.
   Web of Science ®Google Scholar
• Gupta, P.; Satsangi, M.; Satsangi, G. P.; Jangid, A.; Liu, Y.; Pani, S. K.; Kumar, R. Exposure to Respirable and Fine Dust Particle over North-Central India: Chemical Characterization, Source Interpretation, and Health Risk Analysis. Environ. Geochem. Health 2020, 42, 2081–2099. DOI: 10.1007/s10653-019-00461-w.
   PubMed Web of Science ®Google Scholar
• Mehra, M.; Zirzow, F.; Ram, K.; Norra, S. Geochemistry of PM2.5 Aerosols at an Urban Site, Varanasi, in the Eastern Indo-Gangetic Plain during Pre-Monsoon Season. Atmos. Res. 2020, 234, 104734. DOI: 10.1016/j.atmosres.2019.104734.
   Web of Science ®Google Scholar
• Pipal, A. S.; Kulshrestha, A.; Taneja, A. Characterization and Morphological Analysis of Airborne PM2.5 and PM10 in Agra Located in North Central India. Atmos. Environ. 2011, 45, 3621–3630. DOI: 10.1016/j.atmosenv.2011.03.062.
   Web of Science ®Google Scholar
• Pipal, A. S.; Jan, R.; Satsangi, P.; Tiwari, S.; Taneja, A. Study of Surface Morphology, Elemental Composition and Origin of Atmospheric Aerosols (PM2.5 and PM10) over Agra, India. Aerosol Air Qual. Res. 2014, 14, 1685–1700. DOI: 10.4209/aaqr.2014.01.0017.
   Web of Science ®Google Scholar
• Talbi, A.; Kerchich, Y.; Kerbachi, R.; Boughedaoui, M. Assessment of Annual Air Pollution Levels with PM1, PM2.5, PM10 and Associated Heavy Metals in Algiers, Algeria. Environ. Pollut. 2018, 232, 252–263. DOI: 10.1016/j.envpol.2017.09.041.
   PubMed Web of Science ®Google Scholar
• Nirmalkar, J.; Haswani, D.; Singh, A.; Kumar, S.; Sunder Raman, R. Concentrations, Transport Characteristics, and Health Risks of PM2.5-Bound Trace Elements over a National Park in Central India. J. Environ. Manage. 2021, 293, 112904. DOI: 10.1016/j.jenvman.2021.112904.
   PubMed Web of Science ®Google Scholar
• Vreeland, H.; Weber, R.; Bergin, M.; Greenwald, R.; Golan, R.; Russell, A. G.; Verma, V.; Sarnat, J. A. Oxidative Potential of PM2.5 during Atlanta Rush Hour: Measurements of In-Vehicle Dithiothreitol (DTT) Activity. Atmos. Environ. 2017, 165, 169–178. DOI: 10.1016/j.atmosenv.2017.06.044.
   Web of Science ®Google Scholar
• Jeong, C.-H.; Traub, A.; Huang, A.; Hilker, N.; Wang, J. M.; Herod, D.; Dabek-Zlotorzynska, E.; Celo, V.; Evans, G. J. Long-Term Analysis of PM2.5 from 2004 to 2017 in Toronto: Composition, Sources, and Oxidative Potential. Environ. Pollut. 2020, 263, 114652. DOI: 10.1016/j.envpol.2020.114652.
   Web of Science ®Google Scholar
• Wang, Y.; Zhang, Y.; Schauer, J. J.; de Foy, B.; Cai, T.; Zhang, Y. Impacts of Sources on PM2.5 Oxidation Potential during and after the Asia-Pacific Economic Cooperation Conference in Huairou, Beijing. Environ. Sci. Technol 2020, 54, 2585–2594. DOI: 10.1021/acs.est.9b05468.
   PubMed Web of Science ®Google Scholar
• Dubey, S.; John, R.; Singh, M.; Khare, P.; Taneja, A. Seasonal Variation in Metals Concentration Associated with Settled Dust and Their Risk Assessment in School Children of Agra (India). Environ. Adv. 2024, 15, 100480. DOI: 10.1016/j.envadv.2023.100480.
   Google Scholar
• Chu, H.; Liu, Y.; Xu, N.; Xu, J. Concentration, Sources, Influencing Factors and Hazards of Heavy Metals in Indoor and Outdoor Dust: A Review. Environ. Chem. Lett. 2023, 21, 1203–1230. DOI: 10.1007/s10311-022-01546-2.
   Web of Science ®Google Scholar
• Hejami, A. A.; Davis, M.; Prete, D.; Lu, J.; Wang, S. Heavy Metals in Indoor Settled Dusts in Toronto, Canada. Sci. Total Environ. 2020, 703, 134895. DOI: 10.1016/j.scitotenv.2019.134895.
   PubMed Web of Science ®Google Scholar
• Tokalıoğlu, Ş.; Kartal, Ş. Multivariate Analysis of the Data and Speciation of Heavy Metals in Street Dust Samples from the Organized Industrial District in Kayseri (Turkey). Atmos. Environ. 2006, 40, 2797–2805. DOI: 10.1016/j.atmosenv.2006.01.019.
   Web of Science ®Google Scholar
• Wu, L.; Luo, X.-S.; Li, H.; Cang, L.; Yang, J.; Yang, J.; Zhao, Z.; Tang, M. Seasonal Levels, Sources, and Health Risks of Heavy Metals in Atmospheric PM2.5 from Four Functional Areas of Nanjing City, Eastern China. Atmosphere 2019, 10, 419. DOI: 10.3390/atmos10070419.
   Web of Science ®Google Scholar
• Jiang, N.; Liu, X.; Wang, S.; Yu, X.; Yin, S.; Duan, S.; Wang, S.; Zhang, R.; Li, S. Pollution Characterization, Source Identification, and Health Risks of Atmospheric-Particle-Bound Heavy Metals in PM10 and PM2.5 at Multiple Sites in an Emerging Megacity in the Central Region of China. Aerosol Air Qual. Res. 2019, 19, 247–271. DOI: 10.4209/aaqr.2018.07.0275.
   Web of Science ®Google Scholar
• Kermani, M.; Jonidi Jafari, A.; Gholami, M.; Arfaeinia, H.; Shahsavani, A.; Fanaei, F. Characterization, Possible Sources and Health Risk Assessment of PM2.5-Bound Heavy Metals in the Most Industrial City of Iran. J. Environ. Health Sci. Eng. 2021, 19, 151–163. DOI: 10.1007/s40201-020-00589-3.
   PubMed Web of Science ®Google Scholar
• Chen, Y.; Luo, X. S.; Zhao, Z.; Chen, Q.; Wu, D.; Sun, X.; Wu, L.; Jin, L. Summer-Winter Differences of PM2.5 Toxicity to Human Alveolar Epithelial Cells (A549) and the Roles of Transition Metals. Ecotoxicol. Environ. Saf. 2018, 165, 505–509. DOI: 10.1016/j.ecoenv.2018.09.034.
   PubMed Web of Science ®Google Scholar
• Zou, Y.; Jin, C.; Su, Y.; Li, J.; Zhu, B. Water Soluble and Insoluble Components of Urban PM2.5 and Their Cytotoxic Effects on Epithelial Cells (A549) In Vitro. Environ. Pollut. 2016, 212, 627–635. DOI: 10.1016/j.envpol.2016.03.022.
   PubMed Web of Science ®Google Scholar