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Original Articles

RISK CHARACTERIZATION: PRINCIPLES AND PRACTICE

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Pages 337-406 | Published online: 07 Jan 2011

References

  • Dourson , M. L. , Felter , S. P. and Robinson , D. 1996 . Evolution of science-based UFs in noncancer risk assessment . Regul. Toxicol. Pharmacol. , 24 : 108 – 120 .
  • Duan , N. and Mage , D. T. 1997 . Combination of direct and indirect approaches for exposure assessment . J. Exp. Anal. Environ. Epidemiol. , 7 : 439 – 470 .
  • Evans , J. S. , Gray , G. M. , Sielken , R. L. , Smith , A. S. , Valdez-Flores , C. and Graham , J. D. 1994 . Use of probabilistic expert judgment in uncertainty analysis of carcinogenic potency . Regul. Toxicol. Pharmacol. , 20 : 15 – 36 .
  • Graham , J. D. 1995 . Historical perspective on risk assessment in the federal government . Toxicology , 102 : 29 – 52 .
  • Graham , J. D. and Hartwell , J. K. 1997 . The greening of industry: A risk management approach , Cambridge, MA : Harvard University Press .
  • Graham , J. D. and Weiner , J. B. 1995 . “ Confronting risk tradeoffs ” . In Risk vs. risk Tradeoffs in protecting health and the environment , Edited by: Graham , J. D. and Weiner , J. B. 1 – 41 . Cambridge, MA : Harvard University Press .
  • Graham , J. D. , Green , L. and Roberts , M. J. 1988 . In search of safety: Chemicals and cancer risks , Cambridge, MA : Harvard University Press .
  • Green , T. , Lee , R. , Moore , R. B. , Ashby , J. , Willis , G. A. , Lund , V. J. and Clapp , M. J. L. 2000 . Acetochlor-induced rat nasal tumors: Further studies on the mode of action and relevance to humans . Regul. Toxicol. Pharmacol. , 32 : 127 – 135 .
  • Hattis , D. , Banati , P. , Goble , R. and Burmaster , D. E. 1999 . Human interindividual variability in Parameters related to health risks . Risk Anal. , 19 : 711 – 724 .
  • Health Effects Institute. 1999. Reproductive and offspring developmental effects following maternal inhalation exposure to methanol in nonhuman primates. Research Report Number 89. Cambridge, MA: HEI.
  • Holcomb , D. L. , Smith , M. A. , Ware , G. O. , Hung , Y. C , Brackett , R. E. and Doyle , M. P. 1999 . Comparison of six dose-response models for use with food-borne pathogens . Risk Anal. , 19 : 1091 – 1100 .
  • Holland , C. D. and Sielken , R. L. 1993 . Quantitative cancer modeling and risk assessment , Englewood Cliffs, NJ : Prentice Hall .
  • Hwang , J. S. and Chen , J. L. 1999 . An evaluation of risk estimation procedures for mixtures of carcinogens . Risk Anal. , 19 : 1071 – 1076 .
  • IRIS [Integrated Risk Information System]. 1991. 1,3-Butadiene. U.S. Environmental Protection Agency. CASRN 106-99-0. Last revised 1 February.
  • IRIS [Integrated Risk Information System]. 1993. Methyl ten-butyl ether (MTBE). U.S. Environmental Protection Agency. CASRN 1634-04-4. Last revised 1 March.
  • Rachel's Hazardous Waste News. 1993. The precautionary principle.
  • Lomberg , B. 2001 . The skeptical environmentalist: Measuring the real state of the world , Cambridge, MA : Cambridge University Press .
  • Mattie , D. R. , Bates , G. D. , Jepson , G. W. , Fisher , J. W. and McDougal , J. N. 1994 . Determination of skin:air partition coefficients for volatile chemicals: Experimental method and applications . Fundam. Appl. Toxicol. , 22 : 51 – 57 .
  • Mayo , D. G. and Hollander , R. D. 1991 . Acceptable evidence: Science and values in risk management , Oxford : Oxford University Press .
  • McCarthy , I. F. 1991 . “ Average residues vs. tolerances: An overview of industry studies ” . In Pesticide residues and food safety: A harvest of viewpoints , Edited by: Tweedy , B. G. , Dishburger , H. G. , Ballantine , L. G. , McCarthy , J. and Murphy , J. 182 – 191 . Washington, DC : American Chemical Society .
  • McDougal , J. N. 1996 . “ Physiologically based pharmacokinetic modeling ” . In Dermatoxicology , Edited by: Marzulli , F. N. and Maibach , H. I. 37 – 60 . London : Taylor & Francis .
  • Crump , K. S. 1996 . The linearized multistage model and the future of quantitative risk assessment . Hum. Exp. Toxicol. , 15 : 787 – 798 .
  • Cullen , A. C. and Frey , H. C. 1999 . Probabilistic techniques in exposure assessment . Risk Anal. , 14 : 389 – 393 .
  • Davies, J. C, Covello, V. T., and Alien, F. W. 1987. Risk communication. Proc. National Conference on Risk Communication, January, The Conservation Foundation, Washington, DC.
  • Breyer , S. 1993 . Breaking the vicious circle: Toward effective risk regulation , Cambridge, MA : Harvard University Press .
  • Brorby, G. P., Spencer, A. L., and Graf, T. E. 1997. Risk-based corrective actions begin with risk-based investigations--A case study. Proc. Petroleum Hydrocarbons & Organic Chemicals in Ground-water Conference: Prevention, Detection, and Remediation, San Francisco, CA, November.
  • Bruckner , J. V. 2000 . Differences in sensitivity to children and adults to chemical toxicity: The NAS panel report . Toxicol. Pharmacol. , 31 : 280 – 285 .
  • Sielken , R. L. 1987 . Quantitative cancer risk assessments in 2,3,7,8-TCDD . Food Chem. Toxicol. , 25 : 257 – 267 .
  • Burmaster , D. E. and Harris , R. H. 1993 . The magnitude of compounding conservatisms in Superfund risk assessments . Risk Anal. , 13 : 131 – 134 .
  • De Flora , S. 2000 . Threshold mechanisms and site specificity in chromium(VI) carcinogenesis . Carcinogenesis , 21 : 533 – 541 .
  • Denneman, K. 1995. Guidelines for soil remediation. Hague, The Netherlands: Ministry of Housing, Physical Planning, and the Environment.
  • Starr , T. B. and Gibson , J. E. 1985 . The mechanistic toxicology of formaldehyde and its implications for quantitative risk estimation . Annu. Rev. Pharmacol. Toxicol. , 25 : 745 – 767 .
  • Stokey , E. and Zeckhauser , R. 1978 . A primer for policy analysis , New York : W. W. Norton .
  • Tengs , T. O. , Adams , M. E. , Pliskin , J. S. , Safran , D. G. , Siegel , J. E. , Weinstein , M. C and Graham , J. D. 1995 . Five-hundred life-saving interventions and their cost-effectiveness . Risk Anal. , 13 : 369 – 390 .
  • Department of the Environment . 1991 . Policy appraisal and the environment: A guide for government departments , Norwich, UK : Author .
  • Dietrich , D. R. and Swenberg , J. A. 1991 . The presence of alpha-2µ-globulin is necessary for dlimonene promotion of male rat kidney tumors . Cancer Res. , 51 : 3512 – 3521 .
  • Olsen , J. R. 1994 . “ Pharmacokinetics of dioxins and related chemicals ” . In Dioxins and health , Edited by: Schecter , A. New York : Plenum Press .
  • Osterloh, J. 1995. Study of neurological effects of low level methanol in normal subjects and subjects with susceptibility to folate deficiency. San Francisco, CA: Center for Occupational and Environmental Health, University of California.
  • Paustenbach. , D. J. 1988 . Assessment of the developmental risks resulting from occupational exposure to select glycol ethers within the semi-conductor industry . J. Toxicol. Environ. Health , 3 : 53 – 96 .
  • Paustenbach , D. J. 1989 . Health risk assessments: Opportunities and pitfalls . Columbia J. Environ. Law , 41 : 379 – 410 .
  • Paustenbach , D. J. 1995 . The practice of health risk assessment in the United States (1975-1995): How the U.S. and other countries can benefit from that experience . Hum. Ecol. Risk Assess. , 1 : 29 – 79 .
  • Paustenbach , D. J. 2000 . The practice of exposure assessment: A state-of-the-art review . J. Toxicol. Environ. Health B , 3 : 179 – 291 .
  • Paustenbach , D. J. , Meyer , D. M. , Sheehan , P. J. and Lau , V. 1991 . An assessment and quantitative uncertainty analysis of the health risks to workers exposed to chromium contaminated soils . Toxicol. Ind. Health , 7 : 159 – 196 .
  • Peterson , B. J. 2000 . Pesticide residues in food: Problems and data needs . Regul. Toxicol. Pharmacol. , 31 : 297 – 299 .
  • Ponce , R. , Bartell , S. M. , Wong , E. Y. , LaFlamme , D. , Carrington , C , Lee , R. C , Patrick , D. L. , Faustman , E. M. and Bolger. , M. 2000 . Use of quality-adjusted life year weights with dose-response models for public health decisions: A case study of the risks and benefits of fish consumption . Risk Anal. , 20 : 529 – 542 .
  • McDougal , J. N. , Jepson , G. W. , Clewell , H. J. , Gargas , M. L. and Andersen , M. E. 1990 . Dermal absorption of organic chemical vapors in rats and humans . Fundam. Appl. Toxicol. , 14 : 299 – 308 .
  • U.S. Environmental Protection Agency. (1989a). Risk characterization. In Risk assessment guidance for Superfund (RACS), vol. I, Human health evaluation manual (HHEM), Part A, Interim Final, chap. 8. Washington, DC: U.S. Environmental Protection Agency, Office of Emergency and Remedial Response. EPA/540/1-89/002.
  • Environmental Protection Agency. , U.S. 1989b . Proposed amendments to the guidelines for the health assessment of suspect developmental toxicants . Fed. Reg. , 54 : 9386
  • Fayerweather , W. E. , Collins , J. J. , Schnatter , A. R. , Hearne , F. T. , Menning , R. A. and Reyner , D. P. 1999 . Quantifying uncertainty in a risk assessment using human data . Risk Anal. , 19 : 1077 – 1090 .
  • Finkel , A. M. and Golding , D. 1994 . Worst things first , Washington, DC : Resources for the Future .
  • Finley , B. L and Paustenbach , D. J. 1994 . The benefits of probabilistic exposure assessment: Three case studies involving contaminated air, water, and soil . Risk Anal. , 14 : 53 – 73 .
  • Finley , B. , Proctor , D. , Scott , P. , Harrington , N. , Paustenbach , D. and Price , P. 1994 . Recommended distributions for exposure factors frequently used in health risk assessment . Risk Anal. , 14 : 533 – 553 .
  • U.S. Environmental Protection Agency. 1996. Proposed guidelines for carcinogen risk assessment. Washington, DC: Office of Research and Development. EPA/600/P-92/003C.
  • U.S. Environmental Protection Agency. (1997a). Exposure factors handbook. Washington, DC: U.S. Environmental Protection Agency, Office of Health and Environmental Assessment.
  • Agency for Toxic Substances and Disease Registry. 1997. Children's health initiative: Acting on the unique vulnerability of children who dwell near hazardous waste sites. Atlanta, GA: U.S. Department of Health and Human Services, ATSDR.
  • Agency for Toxic Substances and Disease Registry. 1999. Toxicological profile for lead. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service. July
  • U.S. Environmental Protection Agency. (1999b). EPA glossary of IRIS terms. Washington, DC: Integrated Risk Information System, http://www.epa.gov/ngispgm3/iris/gloss8.htm
  • U.S. Environmental Protection Agency. (1999c). Guidance for performing aggregate exposure and risk assessments. Draft, February. Washington, DC: Office of Pesticide Programs.
  • U.S. Environmental Protection Agency. (1999d). Guidance for identifying pesticide chemicals and other substances that have a common mechanism of toxicity. January. Washington, DC: U.S. EPA.
  • U.S. Environmental Protection Agency. (2000a). Exposure and human health reassessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. Part III. Integrated summary and risk characterization for 2,3,7,8-TCDD and related compounds. Washington, DC: National Center for Environmental Assessment. EPA/600/P-00-001. SAB Review Draft, September.
  • U.S. Environmental Protection Agency. (2000b). Available information on assessing exposure from pesticides in food: A user's guide. Washington. DC: Office of Pesticide Programs. June.
  • U.S. Environmental Protection Agency. (2000c). Drinking water health advisories. Washington, DC: Office of Water, http://www.epa.gov/ost/drinking
  • U.S. Environmental Protection Agency. (2000d). Consumption advisories. Washington, DC: Office of Water, http://www.epa.gov/ost/fish
  • U.S. Environmental Protection Agency. (2001a). An SAB report: Review of the office of research and development's reassessment of dioxin. Washington, DC: U.S. EPA Science Advisory Board (SAB), Mort Lippman, Chairman. EPA-SAB-EC-01-006. www.epa.gov/sab
  • U.S. Environmental Protection Agency. (2001b). Improved science-based environmental stakeholder processes: A commentary by the EPA Science Advisory Board. EPA-SAB-EC-COM-01-006. Washington, DC. http://www.epa.gov/sab/eccmO1006.pdf
  • Walker , K. 1992 . Australian environmental policy: Ten case studies , Kensington, , Australia : New South Wales University Press .
  • Weiner , J. B. 2002 . “ Precaution in a multirisk world ” . In Human and ecological risk assessment: Theory and practice , Edited by: Paustenbach , D. J. 1509 – 1532 . New York : John Wiley and Sons .
  • Weinstein , M. C and Fineberg , H. V. 1980 . Clinical decision analysis , Philadelphia : W. B. Saunders .
  • Wildavsky , A. 1995 . But is it true: A citizen's guide to environmental health and safety issues , Cambridge, MA : Harvard University Press .
  • Wilkinson , C. F. , Christoph , G. R. , Julien , E. , Kelley , J. M. , Kronenberg , J. , McCarthy , J. and Reiss , R. 2000 . Assessing the risks of exposures to multiple chemicals with a common mechanism of toxicity: How to cumulate? Regul . Toxicol. Pharmacol. , 31 : 30 – 43 .
  • Williams , P. R. D. , Scott , P. K. , Sheehan , P. J. and Paustenbach , D. J. 2000 . A probabilistic assessment of household exposures to MTBE from drinking water . Hum. ecol. Risk Assess. , 6 : 827 – 849 .
  • Winter , C. K. 1992 . Dietary pesticide risk assessment . Rev. Environ. Contam. Toxicol. , 127 : 23 – 67 .
  • World Health Organization . 1997 . Environmental health criteria 196; Methanol , Geneva, , Switzerland : WHO .
  • Zhang , J. and Li , S. 1997 . Cancer mortality in a Chinese population exposed to hexavalent chromium in water . J. Occup. Environ. Med. , 39 : 315 – 319 .
  • Agency for Toxic Substances and Disease Registry. 2000. Minimal risk levels (MRLs) for hazardous substances. Last updated on February 17, 2000: http://www.atsdr.cdc.gov/mrls.html
  • American Conference of Governmental Industrial Hygienists. 2000. Threshold limit values (TLVs) for chemical substances and physical agents and biological exposure indices (BEIs). Cincinnati, OH: ACGIH.
  • Anderson , P. D. and Weiner , J. B. 1995 . “ Eating fish ” . In Risk vs. risk: Tradeoffs in protecting health and the environment , Edited by: Graham , J. D. and Weiner , J. B. 104 – 123 . Cambridge, MA : Harvard University Press .
  • Andersen , M. E. , Clewell , H. J. III , Gargas , M. L. , Smith , F. A. and Reitz , R. H. 1987 . Physiologically-based pharmacokinetics and risk assessment process for methylene chloride . Toxicol. Appl. Pharmacol. , 87 : 185 – 205 .
  • Archibald , S. O. and Winter , C. K. 1990 . “ Pesticides in our food: Assessing the risk ” . In Chemicals in the human food chain , Edited by: Winter , C. K. , Seiber , J. N. and Nuckton , C. F. 1 – 50 . New York : Van Nostrand Reinhold .
  • Barnes , D. G. and Dourson , M. 1988 . Reference dose (RfD): Description and use in health risk assessments . Regul. Toxicol. Pharmacol. , 8 : 471 – 486 .
  • Berry, M., Garrard, J., and Greene, D. 1993. Reducing lead exposure in Australia: Risk assessment and analysis of economics, social and environmental impacts. Final report, vols. 1 and 2. Canberra, Australia: Australian National Government Publishing Service, Commonwealth of Australia.
  • Bolger , P. M. , Carrington , C. D. and Henry , S. H. 1996 . “ Risk assessment for risk management and regulatory decision-making at the U.S. Food and Drug Administration ” . In Toxicology and risk assessment: Principles, methods and applications , Edited by: Fan , A. M. and Chang , L W. 791 – 798 . New York : Marcel Dekker .
  • Sielken , R. L. 1985 . Some issues in the quantitative modeling portion of cancer risk assessment . Regul. Toxicol. Pharmacol. , 5 : 175 – 181 .
  • Sielken , R. L. , Bretzlaff , R. S. , Valdez-Flores , C , Stevenson , D. E. and Jong , G. 1999 . Cancer dose-response modeling of epidemiological data on worker exposures to aldrin and dieldrin . Risk Anal. , 19 : 1101 – 1111 .
  • Sielken , R. L. , Bretzlaff , R. S. and Stevenson , D. E. 1995 . Challenges to default assumptions stimulate comprehensive realism as a new tier in quantitative cancer risk assessment . Regul. Toxicol. Pharmacol. , 21 : 270 – 280 .
  • Burmaster , D. E. and Anderson , P. D. 1994 . Principles of good practice for the use of Monte Carlo techniques in human health and ecological risk assessment . Risk Anal. , 14 : 477 – 491 .
  • Burmaster , D. E. and Thompson , K. M. 1997 . Estimating exposure point concentrations for surface soils for use in deterministic and probabilistic risk assessments . Hum. Ecol. Risk Assess. , 3 : 363 – 384 .
  • Calabrese , E. J. 2001 . The frequency of U-shaped dose responses in the toxicological literature . Toxicol. Sd. , 62 : 330 – 338 .
  • Calabrese, E. J., and Baldwin, L A. 2001. Scientific foundations of hormesis. Crit. Rev. Toxicol. 31 (special issues 4-5).
  • Clewall , H. J. 1995 . The application of physiologically based pharmacokinetics modeling in human health risk assessment of hazardous substances . Toxicol. Lett. , 79 : 207 – 217 .
  • Clewell , H. J. , Gentry , P. R. , Gearhart , J. M. , Alien , B. C and Andersen , M. E. 1995 . Considering pharmacokinetics and mechanistic information in cancer risk assessments for environmental contaminants: Examples with vinyl chloride and trichloroethylene . Chemosphere , 31 : 2561 – 2578 .
  • Cogliano , V. J. 1997 . Plausible upper bounds: Are their sums plausible? . Risk Anal. , 17 : 77 – 84 .
  • Commission on Risk Assessment and Risk Management. (1997a). Framework for Environmental Risk Management, Presidential/Congressional Commission on Risk Assessment and Risk Management, final report, vol. 1. Washington, DC: CRAM.
  • Commission on Risk Assessment and Risk Management. (1997b). Risk assessment and risk management in regulatory decision-making, Presidential/Congressional Commission on Risk Assessment and Risk Management, final report, vol. 2. Washington, DC: CRAM.
  • Coogan , T. P. , Motz , J. , Snyder , C. A. , Squibb , K. S. and Costa , M. 1991 . Differential DNA-protein crosslinking in lymphocytes and liver following chronic drinking water exposure of rats to potassium chromate . Toxicol. Appl. Pharmacol. , 109 : 60 – 72 .
  • Copeland , T. L. , Paustenbach , D. J. , Harris , M. A. and Otani , J. 1993 . Comparing the results of a Monte Carlo analysis with EPA's reasonable maximum exposed individual (RMEI): A case study of a former wood treatment site . Regul. Toxicol. Pharmacol. , 18 : 275 – 312 .
  • Seed , J. , Brown , R. P. , Olin , S. S. and Foran , J. A. 1995 . Chemical mixtures: Current risk assessment methodologies and future directions . Regul. Toxicol. Pharmacol. , 22 : 76 – 94 .
  • Sheehan , P. J. , Meyer , D. M. , Sauer , M. M. and Paustenbach , D. J. 1991 . Assessment of the human health risks posed by exposure to chromium-contaminated soils . J. Toxicol. Environ. Health , 32 : 161 – 201 .
  • Short , B. G. , Steinhagen , W. G. and Swenberg , J. A. 1989 . Promoting effects of unleaded gasoline and 2,2,4-trimethylpentane on the development of atypical cell foci and renal tubular cell tumors in rats exposed to N-ethyl-N-hydroxyethylnitrosamine . Cancer Res. , 49 : 6369 – 6378 .
  • Thompson , K. M. and Graham , J. D. 1996 . Going beyond the single number: Using probabilistic risk assessment to improve risk management . Hum. Ecol. Risk Assess. , 2 : 1008 – 1034 .
  • Toxicology Excellence for Risk Assessment (TERA). 1999. Comparative dietary risks: Balancing the risks and benefits of fish consumption, http://www.tera.org/news/project%20descriptions/ diet%20 jp.htm
  • Thompson , K. M. , Burmaster , D. E. and Crouch , E. A. C. 1992 . Monte Carlo techniques for quantitative uncertainty analysis in public health assessments . Risk Anal. , 12 : 53 – 63 .
  • Tietenberg , T. 1996 . Environmental economics and policy , New York : HarperCollins .
  • Travis , C. G , Richter , S. A. , Crouch , E. A. G , Wilson , R. and Klema , E. D. 1987 . Cancer risk management: a review of 132 federal regulatory decisions . Environ. Sci. Technol. , 21 : 415 – 420 .
  • Treuschler, L, Klaunig, J., Carney, E., Chambers, J., Conolly, R., Gennings, G, Giesy, J., Hertzberg, R., Klassen, C., Kodell, R., Paustenbach, D., and Yang, R. 2002. Support of science-based decisions concerning evaluation of the toxicology of mixtures: A new beginning. In press.
  • Starr , T. B. 2001 . Significant shortcomings of the U.S. Environmental Protection Agency's latest draft risk characterization for dioxin-like compounds . Toxicol. Sci. , 64 : 7 – 14 .
  • Easterbrook , G. 1995 . A moment on the earth: The coming age of environmental optimism , New York : Viking Penguin .
  • Efron , E. 1984 . The apocalyptics: Cancer and the big lie , New York : Simon and Schuster .
  • El Saadi , O. and Langley , A. 1991 . The health assessment and management of contaminated sites. Adelaide , Australia : South Australian Health Commission .
  • U.S. Environmental Protection Agency. 1983. Health assessment document for dichloromethane (methylene chloride). Washington, DC: Office of Health and Environmental Assessment. EPA-600/8-82-0048. External review draft.
  • U.S. Environmental Protection Agency. (1995b). Elements to consider when drafting EPA risk characterizations. Washington, DC: U.S. EPA, Science Policy Council. http://www.epa.gov/ordntrn/ORD/ spc/rcelemen.htm
  • U.S. Environmental Protection Agency. (1995c). Guidance for risk characterization. Washington, DC: U.S. EPA, Science Policy Council. http/www.epa.gov/ordntrn/ORD/spc/rcguide.htm
  • U.S. Environmental Protection Agency. (1997b). Guiding principles for Monte Carlo analysis. Washington, DC: U.S. EPA, Office of Research and Development. EPA/630/R-97/001.
  • U.S. Environmental Protection Agency. (1999a). Guidelines for carcinogen risk assessment (SAB review copy, July). Washington, DC: U.S. EPA. http://www.epa.gov/ncea/raf/crasab.htm
  • Flegal, R., Last, J., McConnell, E. E., Schenker, M., and Witschi, H. 2001. Scientific review of toxicological and human health issues related to development of a public health goal for chromium VI. Report prepared by the Chromate Toxicity Review Committee, University of California at Davis, Davis, CA.
  • Foster , K. R. , Bernstein , D. E. and Huber , P. W. 1993 . Phantom risk: Scientific inference and the law , Cambridge, MA : MIT Law Press .
  • Freeze , R. A. 2000 . The environmental pendulum , Berkeley : University of California Press .
  • Frey, H. C. 1992. Quantitative analysis of uncertainty and variability in environmental policy making. AAAS/EPA Environmental Science and Engineering Fellow and Research Associate, Center for Energy and Environmental Studies, Carnegie Mellon University, Pittsburgh, September.
  • Frey , H. C. and Rhodes , D. S. 1998 . Characterization and simulation of uncertainty frequency distributions: Effects of distribution choice, variability, uncertainty, and parameter dependence . Hum. Ecol. Risk Assess. , 4 : 423 – 469 .
  • Fryzek , J. P. , Mumma , M. T. , McLaughlin , J. K. , Henderson , B. E. and Blot , W. J. 2001 . Cancer mortality in relation to environmental chromium exposure . J. Occup. Environ. Med. , 43 : 635 – 640 .
  • Gargas , M. L. , Finley , B. L. , Paustenbach , D. J. and Long , T. F. 1999 . “ Environmental health risk assessment: Theory and practice ” . In General and applied toxicology , 2nd , Edited by: Ballantyne , B. , Marrs , T. and Syversen , T. Vol. 3 , 1749 – 1809 . London : Macmillan .
  • Gaylor , D. W. and Chen , J. J. 1996 . A simple upper limit for the sum of the risks of the components in a mixture . Risk Anal. , 16 : 395 – 398 .
  • Ginjaar, L 1996. Risk is more than a number: Reflections on the development of the environmental risk management approach, the Netherlands: Health Council of the Netherlands, Committee on Risk Measures and Risk Assessment, Ministry of Health, Welfare and Sports.
  • Gold , L. S. , Stern , B. R. , Slone , T. H. , Brown , J. P. , Manley , N. B. and Ames , B. N. 1997 . Pesticide residues in food: Investigation of disparities in cancer risk estimates . Cancer Lett. , 117 : 195 – 207 .
  • Gold , M. R. , Siegel , J. E. , Russell , L B. and Weinstein , M. C. 1996 . Cost-effectiveness in health and medicine , New York : Oxford University Press .
  • U.S. Environmental Protection Agency. 1984. Approaches to risk assessment of multiple chemical exposures. EPA 600/9-84-008, RTP, NC. Washington, DC: U.S. EPA.
  • Environmental Protection Agency. , U.S. 1985 . Methodology for characterization of uncertainty in exposure assessments. Prepared by Research Triangle Institute , Research Triangle Park, NC : NTIS PB85240455 .
  • Environmental Protection Agency. , U.S. 1986a . Guidelines for carcinogen risk assessment . Fed. Reg. , 51 : 33992
  • Environmental Protection Agency. , U.S. 1986b . Guidelines for health risk assessment of chemical mixtures . Fed. Reg. , 51 : 34014
  • Environmental Protection Agency. , U.S. 1986c . Guidelines for the health assessment of suspect developmental toxicants . Fed. Reg. , 51 : 34028
  • Environmental Protection Agency. , U.S. 1992 . Guidance on risk characterization for risk managers and risk assessors , Washington, DC : U.S. EPA .
  • Price , P. S. , Curry , C. L. , Goodrum , P. E. , Gray , M. N. , McCrodden , J. I. , Harrington , N. W. , CarlsonLynch , H. and Keenan , R. E. 1996 . Monte Carlo modeling of time-dependent exposures using a microexposure event approach . Risk Anal. , 16 : 339 – 348 .
  • Proctor , D. M. , Otani , J. M. , Finley , B. L. , Paustenbach , D. J. and Sargent , E. V. 2002a . Is hexavalent chromium carcinogenic via ingestion? A state-of-the-science review . J. Toxicol. Environ. Health A , 65 : 701 – 746 .
  • Proctor , D. M. , Shey , E. C , Fehling , K. A. and Finley , B. L. 2002b . Assessment of human health and ecological risks posed by the environmental uses of steel industry slags . Hum. Ecol. Risk Assess. , 8 : 687 – 711 .
  • Putzrath , R. M. 2000 . Reducing uncertainty of risk estimates for mixtures of chemicals within regulatory constraints . Regul. Toxicol. Pharmacol. , 31 : 44 – 52 .
  • Renwick , A. G. and Lazarus , N. R. 1998 . Human variability and non-cancer risk assessment: An analysis of default uncertainty factors . Regul. Toxicol. Pharmacol. , 27 : 3 – 120 .
  • Reitz , R. H. , Garas , M. L , Andersen , M. E. , Provan , W. M. and Green , T. L. 1996 . Predicting cancer risk from vinyl chloride exposure with a physiologically based pharmacokinetic model . Toxicol. Appl. Pharmacol. , 137 : 253 – 267 .
  • IRIS [Integrated Risk Information System]. 2000. Benzene. U.S. Environmental Protection Agency. CASRN 71-43-2. Last revised 19 January.
  • Kang , S. H. , Kodell , R. L. and Chen , J. L. 2000 . Incorporating model uncertainties along with data uncertainties in microbial risk assessment . Regul. Toxicol. Pharmacol. , 32 : 68 – 72 .
  • Kirman , C. R. , Hays , S. M. , Kedderis , G. L , Gargas , M. L. and Strother , D. E. 2000 . Improving cancer dose-response characterization by using physiologically based pharmacokinetic modeling: An analysis of pooled data for acrylonitrile-induced brain tumors to assess cancer potency in the rat . Risk Anal. , 20 : 135 – 151 .
  • Klaassen , C. D. 1996 . Casarett and Doull's toxicology; The basic sciences of poisons , New York : McGraw-Hill .
  • Klaassen , C. D. 2001 . Casarett and Doull's toxicology; The basic sciences of poisons , New York : McGraw-Hill .
  • Kodell , R. L. and Chen , J. J. 1994 . Reducing conservatism in risk estimation for mixtures of carcinogens . Risk Anal. , 14 : 327 – 332 .
  • Kolluru , R. V. 1996 . “ Risk assessment and management: A unified approach ” . In Risk assessment and management handbook , Edited by: Kolluru , R. V. , Bartell , S. M. , Pitblado , R. M. and Stricoff , R. S. 1.3 – 1.41 . New York : McGraw-Hill .
  • Kuykendall , J. R. , Kerger , B. D. , Jarvi , E. J. , Corbett , G. E. and Paustenbach , D. J. 1996 . Measurement of DNA-protein cross-links in human leukocytes following acute ingestion of chromium in drinking water . Carcinogenesis , 17 : 1971 – 1977 .
  • Layard , R. and Glaister , S. 1994 . Cost-benefit analysis , New York : Cambridge University Press .
  • Leung , H. W. 1991 . Development and utilization of physiologically based pharmacokinetic models for toxicological applications . J. Toxicol. Environ. Health , 32 : 247 – 267 .
  • Leung , H. W. 2000 . “ Physiologically based pharmacokinetic modeling ” . In General and applied toxicology , Edited by: Ballantyne , B. , Marrs , T. and Syversen , T. Vol. I , 141 – 154 . London : Macmillan .
  • Leung , H. W. and Paustenbach , D. J. 1995 . Physiologically based pharmacokinetic and pharmacodynamic modeling in health risk assessment and characterization of hazardous substances . Toxicol. Lett. , 78 : 55 – 65 .
  • Renwick , A. G. , Dorne , J. L and Walton , K. 2000 . An analysis of the need for an additional uncertainty factor for infants and children . Regul. Toxicol. Pharmacol. , 31 : 286 – 296 .
  • Rodricks , J. and Taylor , M. R. 1983 . Application of risk assessment to food safety decision making . Regul. Toxicol. Pharmacol. , 3 : 275 – 307 .
  • Ross , J. H. , Dong , M. H. and Krieger , R. I. 2000 . Conservatism in pesticide exposure assessment . Regul. Toxicol. Pharmacol. , 31 : 53 – 58 .
  • Rossman , M. D. and Jones-Williams , W. 1991 . “ Immunopathogenesis of chronic beryllium disease ” . In Beryllium: Biomedical and environmental aspects , Edited by: Rossman , M. D. , Preuss , O. P. and Powers , M. B. 167 – 176 . Baltimore, MD : Williams and Wilkins .
  • Ruckelshaus , W. D. 1983 . Science, risk and public policy . Science , 221 : 1026 – 1028 .
  • U.S. Environmental Protection Agency. (1995a). Policy for risk characterization. Washington, DC: U.S. EPA, Science Policy Council. http://www.epa.gov/ordntn/ORD/spc/rcpolicy.htm
  • Milloy , S. J. 2001 . junk science judo , Washington, DC : Cato Institute Press .
  • Ministry of Housing . 1994 . Environmental quality objectives in the Netherlands. Spatial Planning and Environment , The Hague, , Netherlands : Author .
  • Mirsalis , J. C , Hamilton , C. M. , O'Loughlin , K. G. , Paustenbach , D. J. , Kerger , B. D. and Patierno , S. 1996 . Chromium(VI) at plausible drinking water concentrations is not genotoxic in the in vivo bone marrow micronucleus or liver unscheduled DNA synthesis assays . Environ. Mol. Mutagen. , 28 : 60 – 63 .
  • Morello-Frosch , R. A. , Woodruff , T. J. , Axelrad , D. A. and Caldwell , J. C. 2000 . Air toxics and health risks in California: The public health implications of outdoor concentrations . Risk Anal. , 20 : 273 – 291 .
  • Morey , B. 1999 . Public health goal for hexavalent chromium (Cr VI) , Oakland, CA : Office of Environmental Health Hazard Assessment .
  • Morgan , M. G. and Henrion , M. 1990 . Uncertainty: A guide to dealing with uncertainty in quantitative risk and policy analysis , Cambridge : Cambridge University Press .
  • National Research Council . 1983 . Risk assessment in the federal government: Managing the process , Washington, DC : National Academy Press .
  • National Research Council . 1987 . Regulating pesticides in food: The Delaney paradox , Washington, DC : National Academy Press .
  • National Research Council . 1989 . Improving risk communication , Washington, DC : National Academy Press .
  • National Research Council . 1994 . Science and judgment in risk assessment , Washington, DC : National Academy Press .
  • National Research Council . 1996a . Understanding risk: Informing decisions in a democratic society , Washington, DC : National Academy Press .
  • National Research Council . 1996b . Linking science and technology to society's environmental goals , Washington, DC : National Academy Press .
  • Neumann , D. A. and Kimmel , C. A. 1998 . Human variability in response to chemical exposure , Washington, DC : Inter Life Sciences Institute .
  • Nichols , A. L. and Zeckhauser , R. J. 1984 . The perils of prudence: How conventional risk assessments distort regulations . Regul. Toxicol. Pharmacol. , 8 : 61 – 71 .
  • Occupational Safety and Health Administration. 1999. Permissible exposure limits. U.S. Department of Labor. http://www.osha-slc.gov/SLTC/pel/index.html.
  • Office of Environmental Health Hazard Assessment. 1999. Public health goal for methyl tertiary butyl ether (MTBE) in drinking water. Office of Environmental Health Hazard Assessment. Sacramento, CA: California Environmental Protection Agency.
  • Office of Management and Budget. 2001. Guidelines for ensuring and maximizing the quality, objectivity, utility, and integrity of information disseminated by federal agencies. Washington, DC: Office of Management and Budget, Executive Office of the President. 1 October.

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