Deoxynivalenol: Toxicology and Potential Effects on Humans

References

• Abbas , H. K. , Mirocha , C. J. , Pawlosky , R. J. and Pusch , D. J. 1985 . Effect of cleaning, milling, and baking on deoxynivalenol in wheat . Appl. Environ. Microbiol. , 50 : 482 – 486 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Abbas , H. K. , Mirocha , C. J. and Tuite , J. 1986 . Natural occurrence of deoxynivalenol, 15-acetyl-deoxynivalenol, and zearalenone in refusal factor corn stored since 1972 . Appl. Environ. Microbiol. , 51 : 841 – 843 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Abouzied , M. M. , Azcona , J. I. , Braselton , W. E. and Pestka , J. J. 1991 . Immunochemical assessment of mycotoxins in 1989 grain foods: Evidence for deoxynivalenol (vomitoxin) contamination . Appl. Environ. Microbiol. , 57 : 672 – 677 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Anonymous. 1999 . Outbreaks of Gastrointestinal illness of unknown etiology associated with eating burritos-United States . Morbid. Mortal. Weekly. Rep. , 48 : 210
   Google Scholar
• Anonymous . 2002 . Opinion of the Scientific Committee on Food on Fusarium toxins Part 6: Group evaluation of T-2 toxin, HT-2 Toxin, Nivalenol and Deoxynivalenol. Report of European Commission Scientific Committee on Food, Brussels, Belgium.
   Google Scholar
• Arnold , D. L. , Karpinski , K. F. , McGuire , P. F. , Nera , E. A. , Zawidzka , Z. Z. , Lok , E. , Campbell , J. S. , Tryphonas , L. and Scott , P. M. 1986a . A short-term feeding study with deoxynivalenol (vomitoxin) using rats . Fundam. Appl. Toxicol. , 6 : 691 – 696 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMedGoogle Scholar
• Arnold , D. L. , McGuire , P. F. , Nera , E. A. , Karpinski , K. F. , Bickis , M. G. , Zawidzka , Z. Z. , Fernie , S. and Vesonder , R. F. 1986b . The toxicity of orally administered deoxynivalenol (vomitoxin) in rats and mice . Food Chem. Toxicol. , 24 : 935 – 941 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Association of Food and Drug Officials of the United States . 1975 . Appraised of the safety of chemicals in foods, drugs and cosmetics , Washington , D.C : FDA .
   Google Scholar
• Atroshi , F. , Rizzo , A. F. , Veijalaonen , P. , Lindberg , L. A. , Honkanen-Buzalsi , T. , Andersson , K. , Hirvi , T. and Saloniemi , H. 1994 . The effect of dietary exposure to DON and T-2 toxin on host resistance and serum immunoglobulins of normal and mastitic mice . J. Anim. Physiol. Anim. Nutr. , 71 : 223 – 233 .
   Web of Science ®Google Scholar
• Azcona-Olivera , J. , Ouyang , Y. , Murtha , J. , Chu , F. S. and Pestka , J. J. 1995a . Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): Relationship to toxin distribution and protein synthesis inhibition . Toxicol. Appl. Pharmacol. , 133 : 109 – 120 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Azcona-Olivera , J. , Ouyang , Y. L. , Warner , R. L. , Linz , J. E. and Pestka , J. J. 1995b . Effects of vomitoxin (deoxynivalenol) and cycloheximide on IL-2, 4, 5 and 6 secretion and mRNA levels in murine CD4+ cells . Food Chem.Toxicol. , 33 : 433 – 441 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Banotai , C. , Azcona-Olivera , J. I. , Greene-McDowelle , D. M. and Pestka , J. J. 1999a . Effects of vomitoxin ingestion on murine models for systemic lupus erythematosus . Food Chem. Toxicol. , 37 : 533 – 543 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Banotai , C. , Greene-McDowelle , D. M. , Azcona-Olivera , J. I. and Pestka , J. J. 1999b . Effects of intermittent vomitoxin exposure on body weight, immunoglobulin levels and haematuria in the B6C3F1 mouse . Food Chem. Toxicol. , 37 : 343 – 350 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Berek , L. , Petri , I. B. , Mesterhazy , A. , Teren , J. and Molnar , J. 2001 . Effects of mycotoxins on human immune functions in vitro . Toxicol. In Vitro , 15 : 25 – 30 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Bergsjo , B. , Matre , T. and Nafstad , I. 1992 . Effects of diets with graded levels of deoxynivalenol on performance in growing pigs. . Zentralbl. Veterinarmed. A , 39 : 752 – 758 . [PUBMED] [INFOTRIEVE]
   PubMedGoogle Scholar
• Bergsjo , B. , Herstad , O. and Nafstad , I. 1993a . Effects of feeding deoxynivalenol-contaminated oats on reproduction performance in White Leghorn hens . Br. Poult. Sci. , 34 : 147 – 159 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Bergsjo , B. , Langseth , W. , Nafstad , I. , Jansen , J.H. and Larsen , H.J. 1993b . The effects of naturally deoxynivalenol-contaminated oats on the clinical condition, blood parameters, performance and carcass composition of growing pigs . Vet. Res. Commun. , 17 : 283 – 294 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Bhat , R. V. , Beedu , S. R. , Ramakrishna , Y. and Munshi , K. L. 1989 . Outbreak of trichothecene mycotoxicosis associated with consumption of mould-damaged wheat production in Kashmir Valley, India . Lancet. , 1 : 35 – 37 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Bondy , G. S. and Pestka , J. J. 1991 . Dietary exposure to the trichothecene vomitoxin (deoxynivalenol) stimulates terminal differentiation of Peyer’s patch B cells to IgA secreting plasma cells . Toxicol. Appl. Pharmacol. , 108 : 520 – 530 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Bondy , G. S. and Pestka , J. J. 2000 . Immunomodulation by fungal toxins . J. Toxicol. Environ. Health B , 3 : 109 – 143 . [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Borison , H. L. 1989 . Area postrema: Chemoreceptor circumventricular organ of the medulla oblongata . Prog. Neurobiol. , 32 : 351 – 390 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Bunner , D. L. and Morris , E. R. 1988 . Alteration of multiple cell membrane functions in L-6 myoblasts by T-2 toxin: An important mechanism of action . Toxicol. Appl. Pharmacol. , 92 : 113 – 121 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Canady , R. A. , Coker , R. D. , Egan , S. K. , Krska , R. , Kuiper-Goodman , T. , Olsen , M. , Pestka , J. , Resnik , S. and Schlatter , J. 2001 . “ Deoxynivalenol ” . In Safety evaluation of certain mycotoxins in food , 420 – 529 . Geneva : World Health Organization .
   Google Scholar
• CAST . 2003 . “ Potential economic costs of mycotoxins in the United States ” . In Mycotoxins:Risks in plant, animal, and human systems , 136 – 142 . IA : Council for Agricultural Science and Technology . Task Force Report No. 139. Ames
   Google Scholar
• Clark , D. E. , Wellman , P. J. , Harvey , R. B. and Lerma , M. S. 1987 . Effects of vomitoxin (deoxynivalenol) on conditioned saccharin aversion and food consumption in adult rats . Pharmacol. Biochem. Behav. , 27 : 247 – 252 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Cote , L. M. , Dahlem , A. M. , Yoshizawa , T. , Swanson , S. P. and Buck , W. B. 1986a . Excretion of deoxynivalenol and its metabolite in milk, urine, and feces of lactating dairy cows . J. Dairy Sci. , 69 : 2416 – 2423 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Cote , L. M. , Nicoletti , J. , Swanson , S. J. and Buck , W. 1986b . Production of deepoxydeoxynivalenol (DOM-1), a metabolite of deoxynivalenol, by in vitro rumen incubation . J. Agric. Food Chem. , 1986 : 458 – 460 .
   Web of Science ®Google Scholar
• Cote , L. M. , Buck , W. and Jeffery , E. 1987 . Lack of hepatic microsomal metabolism of deoxynivalenol and its metabolite, DOM-1 . Food Chem. Toxicol. , 25 : 291 – 295 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Debouck , C. , Haubruge , E. , Bollaerts , P. , van Bignoot , D. , Brostaux , Y. , Werry , A. and Rooze , M. 2001 . Skeletal deformities induced by the intraperitoneal administration of deoxynivalenol (vomitoxin) in mice . Int. Orthop. , 25 : 194 – 198 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Dong , W. and Pestka , J. J. 1993 . Persistent dysregulation of IgA production and IgA nephropathy in the B6C3F1 mouse following withdrawal of dietary vomitoxin (deoxynivalenol) . Fundam. Appl. Toxicol. , 20 : 38 – 47 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMedGoogle Scholar
• Dong , W. , Sell , J. E. and Pestka , J. J. 1991 . Quantitative assessment of mesangial immunoglobulin A (IgA) accumulation, elevated circulating IgA immune complexes, and hematuria during vomitoxin-induced IgA nephropathy . Fundam. Appl. Toxicol. , 17 : 197 – 207 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMedGoogle Scholar
• Dong , W. , Azcona Olivera , J. I. , Brooks , K. H. , Linz , J. E. and Pestka , J. J. 1994 . Elevated gene expression and production of interleukins 2, 4, 5, and 6 during exposure to vomitoxin (deoxynivalenol) and cycloheximide in the EL-4 thymoma . Toxicol. Appl. Pharmacol. , 127 : 282 – 290 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ehling , G. , Cockburn , A. , Snowdon , P. and Buschhaus , H. 1997 . The significance of the fusaruim toxin deoxynivalenol (DON) for human and animal health . Fifth Eur. Fusaruim Sem. , 25 : 443 – 447 .
   Google Scholar
• El Banna , A. A. , Hamilton , R. M. , Scott , P. M. and Trenholm , H. L. 1983 . Nontransmission of deoxynivalenol (vomitoxin) to eggs and meat in chickens fed deoxynivalenol-contaminated diets . J. Agric. Food Chem. , 31 : 1381 – 1384 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Eriksen , G. S. and Alexander , J. 1998 . Fusarium toxins in cereals—A risk assessment , 502 Copenhagen : Nordic Council of Ministers, TemaNord .
   Google Scholar
• Fioramonti , J. , Dupuy , C. , Dupuy , J. and Bueno , L. 1993 . The mycotoxin, deoxynivalenol, delays gastric emptying through serotonin-3 receptors in rodents . J. Pharmacol. Exp. Ther. , 266 : 1255 – 1260 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Forsell , J. H. , Witt , M. F. , Tai , J. H. , Jensen , R. and Pestka , J. J. 1986 . Effects of 8-week exposure of the B6C3F1 mouse to dietary deoxynivalenol (vomitoxin) and zearalenone . Food Chem. Toxicol. , 24 : 213 – 219 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Forsell , J. H. , Jensen , R. , Tai , J. H. , Witt , M. , Lin , W. S. and Pestka , J. J. 1987 . Comparison of acute toxicities of deoxynivalenol (vomitoxin) and 15-acetyldeoxynivalenol in the B6C3F1 mouse . Food Chem.Toxicol. , 25 : 155 – 162 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Forsyth , D. M. , Yoshizawa , T. , Morooka , N. and Tuite , J. 1977 . Emetic and refusal activity of deoxynivalenol to swine . Appl. Environ. Microbiol. , 34 : 547 – 552 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Friend , D. W. , Trenholm , H. L. , Elliot , J. I. , Thompson , B. K. and Hartin , K. E. 1982 . Effect of feeding vomitoxin-contaminated wheat to pigs . Can. J. Anim. Sci. , 62 : 1211 – 1222 .
   Web of Science ®Google Scholar
• Gareis , M. , Bauer , J. and Gedek , J. 1987 . On the metabolism of the mycotoxin deoxynivalenol in the isolated perfused rat liver . Mycotoxin Res. , 3 : 25 – 32 .
   PubMedGoogle Scholar
• Gauvreau , H. C. 2000 . Toxicokinetic, tissue residue, and metabolic studies of deoxynivalenol (vomitoxin) in turkeys , Vancouver , BC : Simon Fraser University . PhD dissertation
   Google Scholar
• Greene , D. M. , Azcona Olivera , J. I. and Pestka , J. J. 1994 . Vomitoxin (deoxynivalenol)-induced IgA nephropathy in the B6C3F1 mouse: Dose response and male predilection . Toxicology , 92 : 245 – 260 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Grove , J. F. 1988 . Non-macrocyclic trichothecenes . Nat. Prod. Rep. , 5 : 187 – 209 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Grove , J. F. 2000 . Non-macrocyclic trichothecenes. Part 2 . Prog. Chem. Org. Nat. Prod. , 69 : 1 – 70 .
   Google Scholar
• Hamilton , R. M. , Thompson , B. K. , Trenholm , H. L. , Fiser , P. S. and Greenhalgh , R. 1985a . Effects of feeding white Leghorn hens diets that contain deoxynivalenol (vomitoxin)-contaminated wheat . Poult. Sci. , 64 : 1840 – 1852 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Hamilton , R. M. , Trenholm , H. L. , Thompson , B. K. and Greenhalgh , R. 1985b . The tolerance of white Leghorn and broiler chicks, and turkey poults to diets that contained deoxynivalenol (vomi toxin)-contaminated wheat . Poult. Sci. , 64 : 273 – 286 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Hart , L. P. and Braselton , W. E. J. 1983 . Distribution of vomitoxin in dry milled fractions of wheat infected with Gibberella zeae . J. Agric. Food Chem. , 31 : 657 – 659 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Harvey , R. B. , Kubena , L. F. , Huff , W. E. , Elissalde , M. H. and Phillips , T. D. 1991 . Hematologic and immunologic toxicity of deoxynivalenol (DON)-contaminated diets to growing chickens . Bull. Environ. Contam. Toxicol. , 46 : 410 – 416 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• He , P. , Young , L. G. and Forsberg , C. 1992 . Microbial transformation of deoxynivalenol (vomitoxin) . Appl. Environ. Microbiol. , 58 : 3857 – 3863 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Hedman , R. and Pettersson , H. 1997 . Transformation of nivalenol by gastrointestinal microbes . Arch. Tierernahr. , 50 : 321 – 329 . [PUBMED] [INFOTRIEVE]
   PubMedGoogle Scholar
• Heller , R. A. , Song , K. , Onasch , M. A. , Fischer , W. H. , Chang , D. and Ringold , G. M. 1990 . Complementary DNA cloning of a receptor for tumor necrosis factor and demonstration of a shed form of the receptor . Proc. Natl. Acad. Sci. USA , 87 : 6151 – 6155 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Huff , W. E. , Doerr , J. A. , Hamilton , P. B. and Vesonder , R. F. 1981 . Acute toxicity of vomitoxin (deoxynivalenol) in broiler chickens . Poult. Sci. , 60 : 1412 – 1414 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Huff , W. E. , Kubena , L. F. , Harvey , R. B. , Hagler , W. M. , Swanson , S. P. , Phillips , T. D. and Creger , C. R. 1986 . Individual and combined effects of aflatoxin and deoxynivalenol (DON, vomitoxin) in broiler chickens . Poult. Sci. , 65 : 1291 – 1298 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Hughes , D. M. , Gahl , M. J. , Graham , C. H. and Grieb , S. L. 1999 . Overt signs of toxicity to dogs and cats of dietary deoxynivalenol . J. Anim. Sci. , 77 : 693 – 700 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Hunder , G. , Schumann , K. , Strugala , G. , Gropp , J. , Fichtl , B. and Forth , W. 1991 . Influence of subchronic exposure to low dietary deoxynivalenol, a trichothecene mycotoxin, on intestinal absorption of nutrients in mice . Food Chem. Toxicol. , 29 : 809 – 814 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• IARC . 1993 . Some naturally occurring substances: Food items and constituents, heterocyclcamines and mycotoxins . IARC Monog. Eval. Carcinogen. Risks Hum. , 56 : 599
   Google Scholar
• Ihara , T. , Sugamata , M. , Sekijima , M. , Okumura , H. , Yoshino , N. and Ueno , Y. 1997 . Apoptotic cellular damage in mice after T-2 toxin-induced acute toxicosis . Nat. Toxins. , 5 : 141 – 145 . [PUBMED] [INFOTRIEVE]
   PubMedGoogle Scholar
• Ihara , T. , Yamamoto , T. , Sugamata , M. , Okumura , H. and Ueno , Y. 1998 . The process of ultrastructural changes from nuclei to apoptotic body . Virchows Arch. , 433 : 443 – 447 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Iordanov , M. S. , Paranjape , J. M. , Zhou , A. , Wong , J. , Williams , B. R. , Meurs , E. F. , Silverman , R. H. and Magun , B. E. 2000 . Activation of p38 mitogen-activated protein kinase and c-Jun NH(2)- terminal kinase by double-stranded RNA and encephalomyocarditis virus: Involvement of RNase L, protein kinase R, and alternative pathways . Mol. Cell Biol. , 20 : 617 – 627 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Islam , Z. and Pestka , J. J. 2003 . Role of IL-1{beta} in endotoxin potentiation of deoxynivalenol-induced corticosterone response and leukocyte apoptosis in mice . Toxicol. Sci. , 74 : 93 – 102 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Islam , Z. , Nagase , M. , Yoshizawa , T. , Yamauchi , K. and Sakato , N. 1998 . T-2 toxin induces thymic apoptosis in vivo in mice . Toxicol. Appl. Pharmacol. , 148 : 205 – 214 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Islam , Z. , Moon , Y. S. , Zhou , H. R. , King , L. E. , Fraker , P. J. and Pestka , J. J. 2002 . Endotoxin potentiation of trichothecene-induced lymphocyte apoptosis is mediated by up-regulation of glucocorticoids . Toxicol. Appl. Pharmacol. , 180 : 43 – 55 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Islam , Z. , King , L. E. , Fraker , P. J. and Pestka , J. J. 2003 . Differential induction of glucocorticoid-dependent apoptosis in murine lymphoid subpopulations in vivo following coexposure to lipopolysaccharide and vomitoxin (deoxynivalenol) . Toxicol. Appl. Pharmacol. , 187 : 69 – 79 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Iverson , F. , Armstrong , C. , Nera , E. , Truelove , J. , Fernie , S. , Scott , P. , Stapley , R. , Hayward , S. and Gunner , S. 1995 . Chronic feeding study of deoxynivalenol in B6C3F1 male and female mice . Teratogen. Carcinogen. Mutagen. , 15 : 283 – 306 . [CROSSREF]
   PubMedGoogle Scholar
• Jackson , L. S. and Bullerman , L. B. 1999 . Effect of processing on Fusarium mycotoxins . Adv. Exp. Med. Biol. , 459 : 243 – 261 . [PUBMED] [INFOTRIEVE]
   PubMedGoogle Scholar
• Ji , G. E. , Park , S. Y. , Wong , S. S. and Pestka , J. J. 1998 . Modulation of nitric oxide, hydrogen peroxide and cytokine production in a clonal macrophage model by the trichothecene vomitoxin (deoxynivalenol) . Toxicology , 125 : 203 – 214 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Joffe , A. Z. 1978 . “ Fusarium poae and F. sporotichiodes as principal causal agents of alimentary toxic aleukia. ” . In Mycotoxic fungi, mycotoxins and mycotoxicoses: An encyclopedia and book , Edited by: Wyllie , T. D. and Morehouse , L. G. 21 – 86 . New York : Marcel Dekker. .
   Google Scholar
• Khera , K. S. , Whalen , C. , Angers , G. , Vesonder , R. F. and Kuiper-Goodman , T. 1982 . Embryotoxicity of 4-deoxynivalenol (vomitoxin) in mice . Bull. Environ. Contam Toxicol. , 29 : 487 – 491 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Khera , K. S. , Arnold , D. L. , Whalen , C. , Angers , G. and Scott , P. M. 1984 . Vomitoxin (4-deoxynivalenol): Effects on reproduction of mice and rats . Toxicol. Appl. Pharmacol. , 74 : 345 – 356 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Khera , K. S. , Whalen , C. and Angers , G. 1986 . A teratology study on vomitoxin (4-deoxynivalenol) in rabbits . Food Chem. Toxicol. , 24 : 421 – 424 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Knasmuller , S. , Bresgen , N. , Kassie , F. , Mersch-Sundermann , V. , Gelderblom , W. , Zohrer , E. and Eckl , P. M. 1997 . Genotoxic effects of three Fusarium mycotoxins, fumonisin B1, moniliformin and vomitoxin in bacteria and in primary cultures of rat hepatocytes . Mutat. Res. , 391 : 39 – 48 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Kristensen , P. , Irgens , L. M. , Andersen , A. , Bye , A. S. and Sundheim , L. 1997 . Gestational age, birth weight, and perinatal death among births to Norwegian farmers, 1967–1991 . Am. J. Epidemiol. , 146 : 329 – 338 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Kubena , L. F. , Swanson , S. P. , Harvey , R. B. , Fletcher , O. J. , Rowe , L. D. and Phillips , T. D. 1985 . Effects of feeding deoxynivalenol (vomitoxin)-contaminated wheat to growing chicks . Poult. Sci. , 64 : 1649 – 1655 .
   Web of Science ®Google Scholar
• Kubena , L. F. , Harvey , R. B. , Corrier , D. E. and Huff , W. E. 1987 . Effects of feeding deoxynivalenol (DON, vomitoxin)-contaminated wheat to female White Leghorn chickens from day old through egg production . Poult. Sci. , 66 : 1612 – 1618 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Kuiper-Goodman , T. , Miller , J. D. and Trenholm , H. L. 1994 . “ Prevention of mycotoxicoses through risk management and risk assessment ” . In Mycotoxins in grains , Edited by: Miller , J. D. and Trenholm , H. L. 439 – 469 . St. Paul , MN : Eagan Press. .
   Google Scholar
• Lake , B. G. , Phillips , J. C. , Walters , D. G. , Bayley , D. L. , Cook , M. W. , Thomas , L. V. , Gilbert , J. , Startin , J. R. , Baldwin , N. C. and Bycroft , B. W. 1987 . Studies on the metabolism of deoxynivalenol in the rat . Food Chem. Toxicol. , 25 : 589 – 592 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lewis , C. W. , Smith , J. E. , Anderson , J. G. and Freshney , R. I. 1999 . Increased cytotoxicity of food-borne mycotoxins toward human cell lines in vitro via enhanced cytochrome p450 expression using the MTT bioassay . Mycopathologia. , 148 : 97 – 102 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Li , F. Q. , Li , Y. W. , Luo , X. Y. and Yoshizawa , T. 2002 . Fusarium toxins in wheat from an area in Henan Province, PR China, with a previous human red mould intoxication episode . Food Addit. Contam. , 19 : 163 – 167 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Li , S. , Ouyang , Y. , Yang , G. H. and Pestka , J. J. 2000 . Modulation of transcription factor AP-1 activity in murine EL-4 thymoma cells by vomitoxin (deoxynivalenol) . Toxicol. Appl. Pharmacol. , 163 : 17 – 25 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Li , S. , Ouyang , Y. L. , Dong , W. and Pestka , J. J. 1997 . Superinduction of IL-2 gene expression by vomitoxin (deoxynivalenol) involves increased mRNA stability . Toxicol. Appl. Pharmacol. , 147 : 331 – 342 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lombaert , G. A. , Pellaers , P. , Roscoe , V. , Mankotia , M. , Neil , R. and Scott , P. M. 2003 . Mycotoxins in infant cereal foods from the Canadian retail market . Food Addit. Contam. , 20 : 494 – 504 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lun , A. K. , Young , L. G. , Moran , E. T. , Hunter , D. B. and Rodriguez , J. P. 1986 . Effects of feeding hens a high level of vomitoxin-contaminated corn on performance and tissue residues . Poult. Sci. , 65 : 1095 – 1099 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Lun , A. K. , Moran , E. T. , Young , L. G. and McMillan , E. G. 1988 . Disappearance of deoxynivalenol from digesta progressing along the chicken’s gastrointestinal tract after intubation with feed containing contaminated corn . Bull. Environ. Contam Toxicol. , 40 : 317 – 324 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Lun , A. K. , Moran , E. T. , Young , L. G. and McMillan , E. G. 1989 . Absorption and elimination of an oral dose of 3H-deoxynivalenol in colostomized and intact chickens . Bull. Environ. Contam Toxicol. , 42 : 919 – 925 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Luo , Y. , Yoshizawa , T. and Katayama , T. 1990 . Comparative study on the natural occurrence of Fusarium mycotoxins (trichothecenes and zearalenone) in corn and wheat from high- and low-risk areas for human esophogeal cancer in China . Appl. Environ. Microbiol. , 56 : 3723 – 3726 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Luo , X. Food poisoning caused by Fusarium toxins . Proc. Second Asian Conf. Food Safety . pp. 129 – 136 .
   Google Scholar
• McMullen , M. , Jones , R. and Gallenberg , D. 1997 . Scab of wheat and barley: A re-emerging disease of devastating impact . Plant Dis. , 81 : 1340 – 1348 .
   PubMed Web of Science ®Google Scholar
• Meky , F. A. , Hardie , L. J. , Evans , S. W. and Wild , C. P. 2001 . Deoxynivalenol-induced immunomodulation of human lymphocyte proliferation and cytokine production . Food Chem. Toxicol. , 39 : 827 – 836 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Meky , F. A. , Turner , P. C. , Ashcroft , A. E. , Miller , J. D. , Qiao , Y. L. , Roth , M. J. and Wild , C. P. 2003 . Development of a urinary biomarker of human exposure to deoxynivalenol . Food Chem. Toxicol. , 41 : 265 – 273 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Miller , J. D. , Greehalgh , R. , Wang , Y. Z. and Lu , M. 1991 . Trichothecene chemotype of three Fusarium species . Mycologia. , 83 : 121 – 130 .
   Web of Science ®Google Scholar
• Miura , K. , Nakajima , Y. , Yamanaka , N. , Terao , K. , Shibato , T. and Ishino , S. 1998 . Induction of apoptosis with fusarenon-X in mouse thymocytes . Toxicology , 127 : 195 – 206 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Moon , Y. and Pestka , J. J. 2002 . Vomitoxin-induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen-activated protein kinases . Toxicol. Sci. , 69 : 373 – 382 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Morooka , N. , Uratsuji , N. , Yoshizawa , T. and Yamamoto , H. 1972 . Studies on the toxic effects of barley infected with Fusarium spp . J. Food Hyg. Soc. Jpn. , 13 : 368 – 375 .
   Google Scholar
• Morrissey , R. E. 1984 . Teratological study of Fischer rats fed diet containing added vomitoxin . Food Chem. Toxicol. , 22 : 453 – 457 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Morrissey , R. E. and Vesonder , R. F. 1985 . Effect of deoxynivalenol (vomitoxin) on fertility, pregnancy, and postnatal development of Sprague-Dawley rats . Appl. Environ. Microbiol. , 49 : 1062 – 1066 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Morrissey , R. E. , Norred , W. P. and Vesonder , R. F. 1985 . Subchronic toxicity of vomitoxin in Sprague-Dawley rats . Food Chem. Toxicol. , 23 : 995 – 999 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Nejdfors , P. , Ekelund , M. , Jeppsson , B. and Westrom , B. R. 2000 . Mucosal in vitro permeability in the intestinal tract of the pig, the rat, and man . Scand. J. Gastroenterol. , 35 : 501 – 507 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ossenkopp , K. P. , Hirst , M. and Rapley , W. A. 1994 . Deoxynivalenol (vomitoxin)-induced conditioned taste aversions in rats are mediated by the chemosensitive area postrema . Pharmacol. Biochem. Behav. , 47 : 363 – 367 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ouyang , Y. L. , Azcona Olivera , J. I. and Pestka , J. J. 1995 . Effects of trichothecene structure on cytokine secretion and gene expression in murine CD4+ T-cells . Toxicology. , 104 : 187 – 202 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ouyang , Y. L. , Azcona Olivera , J. I. , Murtha , J. and Pestka , J. J. 1996a . Vomitoxin-mediated IL-2, IL-4, and IL-5 superinduction in murine CD4+ T cells stimulated with phorbol ester calcium ionophore: Relation to kinetics of proliferation . Toxicol. Appl. Pharmacol. , 138 : 324 – 334 . [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ouyang , Y. L. , Li , S. and Pestka , J. J. 1996b . Effects of vomitoxin (deoxynivalenol) on transcription factor NF- kappa B/Rel binding activity in murine EL-4 thymoma and primary CD4+ T cells . Toxicol. Appl. Pharmacol. , 140 : 328 – 336 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Øvernes , G. , Matre , T. , Sivertsen , T. , Larsen , H. J. , Langseth , W. , Reitan , L. J. and Jansen , J. H. 1997 . Effects of diets with graded levels of naturally deoxynivalenol-contaminated oats on immune response in growing pigs . Zentralbl. Veterinarmed. A. , 44 : 539 – 550 .
   PubMedGoogle Scholar
• Penner , K. , Gray , J. and Pestka , J. J. 2003 . Human cytokine mRNA response to deoxynivalenol using whole blood cultures . Toxicologist , 72 ( 1 ) : 121
   Google Scholar
• Pestka , J. J. and Casale , W. L. 1990 . Naturally occurring fungal toxins . Adv. Environ. Sci. Technol. , 23 : 613 – 638 .
   Google Scholar
• Pestka , J. J. and Zhou , H. R. 2003 . Hck- and PKR-dependent mitogen-activated protein kinase phosphorylation and AP-1, C/EBP and NF-?B activation precedes deoxynivalenol-induced TNF-α and MIP-2 expression . Toxicologist , 72 : 121
   Google Scholar
• Pestka , J. J. , Lin , W. S. and Miller , E. R. 1987a . Emetic activity of the trichothecene 15-acetyldeoxynivalenol in swine . Food Chem. Toxicol. , 25 : 855 – 858 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Pestka , J. J. , Tai , J. H. , Witt , M. F. , Dixon , D. E. and Forsell , J. H. 1987b . Suppression of immune response in the B6C3F1 mouse after dietary exposure to the Fusarium mycotoxins deoxynivalenol (vomitoxin) and zearalenone . Food Chem. Toxicol. , 25 : 297 – 304 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Pestka , J. J. , Moorman , M. A. and Warner , R. L. 1989 . Dysregulation of IgA production and IgA nephropathy induced by the trichothecene vomitoxin . Food Chem. Toxicol. , 27 : 361 – 368 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Pestka , J. J. , Dong , W. , Warner , R. L. , Rasooly , L. and Bondy , G. S. 1990a . Effect of dietary administration of the trichothecene vomitoxin (deoxynivalenol) on IgA and IgG secretion by Peyer’s patch and splenic lymphocytes . Food Chem. Toxicol. , 28 : 693 – 699 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Pestka , J. J. , Dong , W. , Warner , R. L. , Rasooly , L. , Bondy , G. S. and Brooks , K. H. 1990b . Elevated membrane IgA+ and CD4+ (T helper) populations in murine Peyer’s patch and splenic lymphocytes during dietary administration of the trichothecene vomitoxin (deoxynivalenol) . Food Chem. Toxicol. , 28 : 409 – 420 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Pestka , J. J. , Azcona Olivera , J. I. , Plattner , R. D. , Minervini , F. , Doko , M. B. and Visconti , A. 1994a . Comparative assessment of fumonisin in grain-based foods by ELISA, GC-MS, and HPLC . J. Food Prot. , 57 : 169 – 172 .
   PubMed Web of Science ®Google Scholar
• Pestka , J. J. , Yon , D. and King , L.E. 1994b . Flow cytometric analysis of the effects of in vitro exposure to vomitoxin (deoxynivalenol) on apoptosis in murine T, B and IgA+ cells . Food Chem. Toxicol. , 32 : 1125 – 1136 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Pieters , M. N. , Fiolet , D. C. M. and Baars , A. J. Deoxynivalenol Derivation of concentration limits in wheat and wheat containing food products. National Institute of Public Health and the Environment . Report 388802 018: 1–32 . 1998 .
   Google Scholar
• Prelusky , D. B. 1996 . A study on the effect of deoxynivalenol on serotonin receptor binding in pig brain membranes . J. Environ. Sci. Health B , 31 : 1103 – 1117 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Prelusky , D. B. and Trenholm , H. L. 1991a . Non-accumulation of residues in swine consuming deoxynivalenol-contaminated diets . J. Food Sci. , 57 : 801 – 802 .
   Web of Science ®Google Scholar
• Prelusky , D. B. and Trenholm , H. L. 1991b . Tissue distribution of deoxynivalenol in swine dosed intravenously . J. Agric. Food Chem. , 39 : 748 – 752 . [CROSSREF]
   Web of Science ®Google Scholar
• Prelusky , D. B. and Trenholm , H. L. 1993 . The efficacy of various classes of anti-emetics in preventing deoxynivalenol-induced vomiting in swine . Nat. Toxins , 1 : 296 – 302 . [PUBMED] [INFOTRIEVE]
   PubMedGoogle Scholar
• Prelusky , D. B. , Trenholm , H. L. , Lawrence , G. A. and Scott , P. M. 1984 . Nontransmission of deoxynivalenol (vomitoxin) to milk following oral administration to dairy cows . J. Environ. Sci. Health B , 19 : 593 – 609 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Prelusky , D. B. , Hamilton , R. M. , Trenholm , H. L. and Miller , J. D. 1986a . Tissue distribution and excretion of radioactivity following administration of 14C-labeled deoxynivalenol to White Leghorn hens . Fundam. Appl. Toxicol. , 7 : 635 – 645 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMedGoogle Scholar
• Prelusky , D. B. , Veira , D. M. , Trenholm , H. L. and Hartin , K. E. 1986b . Excretion profiles of the mycotoxin deoxynivalenol, following oral and intravenous administration to sheep . Fundam. Appl. Toxicol. , 6 : 356 – 363 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMedGoogle Scholar
• Prelusky , D. B. , Hartin , K. E. , Trenholm , H. L. and Miller , J. D. 1988 . Pharmacokinetic fate of 14C-labeled deoxynivalenol in swine . Fundam. Appl. Toxicol. , 10 : 276 – 286 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMedGoogle Scholar
• Prelusky , D. B. , Yeung , J. M. , Thompson , B. K. and Trenholm , H. L. 1992 . Effect of deoxynivalenol on neurotransmitters in discrete regions of swine brain . Arch. Environ. Contam. Toxicol. , 22 : 36 – 40 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Prelusky , D. B. , Rotter , B. A. , Rotter , R. G. Miller and Trenholm . 1994a . “ Toxicology of mycotoxins ” . In In Mycotoxins in grain: Compounds other than aflatoxin , Edited by: Miller , J. D. and Trenholm , H. L. 359 – 403 . St. Paul , MN : Eagan Press. .
   Google Scholar
• Prelusky , D. B. , Gerdes , R. G. , Underhill , K. L. , Rotter , B. A. , Jui , P. Y. and Trenholm , H. L. 1994b . Effects of low-level dietary deoxynivalenol on haematological and clinical parameters of the pig . Nat. Toxins , 2 : 97 – 104 . [PUBMED] [INFOTRIEVE]
   PubMedGoogle Scholar
• Proctor , R. H. , Hohn , T. M. and McCormick , S. P. 1995 . Reduced virulence of Gibberella zeae caused by disruption of a trichothecene toxin biosynthetic gene . Mol. Plant Microbe Interact. , 8 : 593 – 601 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Rasooly , L. and Pestka , J. J. 1992 . Vomitoxin-induced dysregulation of serum IgA, IgM and IgG reactive with gut bacterial and self antigens . Food Chem. Toxicol. , 30 : 499 – 504 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Rasooly , L. and Pestka , J. J. 1994 . Polyclonal autoreactive IgA increase and mesangial deposition during vomitoxin-induced IgA nephropathy in the BALB/c mouse . Food Chem. Toxicol. , 32 : 329 – 336 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Rasooly , L. , Abouzied , M. M , Brooks , K. H. and Pestka , J. J. 1994 . Polyspecific and autoreactive IgA secreted by hybridomas derived from Peyer’s patches of vomitoxin-fed mice: Characterization and possible pathogenic role in IgA nephropathy . Food Chem. Toxicol. , 32 : 337 – 348 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Rizzo , A. F. , Atroshi , F. , Ahotupa , M. , Sankari , S. and Elovaara , E. 1994 . Protective effect of antioxidants against free radical-mediated lipid peroxidation induced by DON or T-2 toxin . Zentralbl. Veterinarmed. A , 41 : 81 – 90 . [PUBMED] [INFOTRIEVE]
   PubMedGoogle Scholar
• Robbana-Barnat , S. , Loridon-Rosa , B. , Cohen , H. , Lafarge-Frayssinet , C. , Neish , G. A. and Frayssinet , C. 1987 . Protein synthesis inhibition and cardiac lesions associated with deoxynivalenol ingestion in mice . Food Addit. Contam. , 4 : 49 – 56 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Robbana-Barnat , T. , Lafarge Frayssinet , C. , Cohen , H. , Neish , G. A. and Frayssinet , C. 1988 . Immunosuppressive properties of deoxynivalenol . Toxicology , 48 : 155 – 166 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Rogers , C. G. and Heroux-Metcalf , C. 1983 . Cytotoxicity and absence of mutagenic activity of vomitoxin (4-deoxynivalenol) in a hepatocyte-mediated mutation assay with V79 Chinese hamster lung cells . Cancer Lett. , 20 : 29 – 35 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Rotter , B. A. , Rotter , R. G. , Thompson , B. K. and Trenholm , H. L. 1992 . Investigations in the use of mice exposed to mycotoxins as a model for growing pigs . J. Toxicol. Environ. Health , 37 : 329 – 339 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Rotter , B. A. , Thompson , B. K. , Lessard , M. , Trenholm , H. L. and Tryphonas , H. 1994 . Influence of low-level exposure to Fusarium mycotoxins on selected immunological and hematological parameters in young swine . Fundam. Appl. Toxicol. , 23 : 117 – 124 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMedGoogle Scholar
• Rotter , B. A. , Prelusky , D. B. and Pestka , J. J. 1996 . Toxicology of deoxynivalenol (vomitoxin) . J. Toxicol. Environ. Health , 48 : 1 – 34 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Schaafsma , A. W. 2002 . Economic changes imposed by mycotoxins in food grains: Case study of deoxynivalenol in winter wheat . Adv. Exp. Med. Biol. , 504 : 271 – 276 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Scott , P. M. 1996 . Mycotoxins transmitted into beer from contaminated grains during brewing . J. AOAC Int. , 79 : 875 – 882 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Shifrin , V. I. and Anderson , P. 1999 . Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis . J. Biol. Chem. , 274 : 13985 – 13992 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Shinozuka , J. , Guanmin , L. , Uetsuka , K. , Nakayama , H. and Doi , K. 1997 . Process of the development of T-2 toxin-induced apoptosis in the lymphoid organs of mice . Exp. Anim. , 46 : 117 – 126 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Shinozuka , J. , Suzuki , M. , Noguchi , N. , Sugimoto , T. , Uetsuka , K. , Nakayama , H. and Doi , K. 1998 . T-2 toxin-induced apoptosis in hematopoietic tissues of mice . Toxicol. Pathol. , 26 : 674 – 681 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Sugita-Konishi , Y. and Pestka , J. J. 2001 . Differential upregulation of TNF-alpha, IL-6, and IL-8 production by deoxynivalenol (vomitoxin) and other 8-ketotrichothecenes in a human macrophage model . J. Toxicol. Environ. Health A , 64 : 619 – 636 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Sugita-Kinoshi , Y. , Hara-Kudo , Y. , Kasuga , F. and Kumagai , S. 1998 . The effects of trichothecenes on host defense against infectious diseases . Mycotoxins , 47 : 19 – 23 .
   Google Scholar
• Sundstol-Eriksen , G. and Pettersson , H. 2003 . Lack of de-epoxidation of type B trichothecenes in incubates with human faeces . Food Addit. Contam. , 20 : 579 – 582 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMedGoogle Scholar
• Sun , X. M. , Zhang , X. H. , Wang , H. Y. , Cao , W. J. , Yan , X. , Zuo , L. F. , Wang , J. L. and Wang , F. R. 2002 . Effects of sterigmatocystin, deoxynivalenol and aflatoxin G1 on apoptosis of human peripheral blood lymphocytes in vitro . Biomed. Environ. Sci. , 15 : 145 – 152 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Swamy , H. V. , Smith , T. K. , MacDonald , E. J. , Boermans , H. J. and Squires , E. J. 2002 . Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on swine performance, brain regional neurochemistry, and serum chemistry and the efficacy of a polymeric glucomannan mycotoxin adsorbent. . J. Anim. Sci. , 80 : 3257 – 3267 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Swanson , S. P. , Helaszek , C. , Buck , W. B. , Rood , H. D. and Haschek , W. M. 1988 . The role of intestinal microflora in the metabolism of trichothecene mycotoxins. . Food Chem. Toxicol. , 26 : 823 – 829 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Szelenyi , I. , Herold , H. and Gothert , M. 1994 . Emesis induced in domestic pigs: A new experimental tool for detection of antiemetic drugs and for evaluation of emetogenic potential of new anticancer agents. . J. Pharmacol. Toxicol. Methods , 32 : 109 – 116 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Szkudelska , K. , Szkudelski , T. and Nogowski , L. 2002 . Short-time deoxynivalenol treatment induces metabolic disturbances in the rat. . Toxicol. Lett. , 136 : 25 – 31 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Trenholm , H. L. , Hamilton , R. M. , Friend , D. W. , Thompson , B. K. and Hartin , K. E. 1984 . Feeding trials with vomitoxin (deoxynivalenol)-contaminated wheat: Effects on swine, poultry, and dairy cattle. . J. Am. Vet. Med. Assoc. , 185 : 527 – 531 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Trenholm , H. L. , Thompson , B. K. , Hartin , K. E. , Greenhalgh , R. and McAllister , A. J. 1985 . Ingestion of vomitoxin (deoxynivalenol)-contaminated wheat by nonlactating dairy cows. . J. Dairy Sci. , 68 : 1000 – 1005 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Tryphonas , H. , O’Grady , L. , Arnold , D. L. , McGuire , P. F. , Karpinski , K. and Vesonder , R. F. 1984 . Effect of deoxynivalenol (vomitoxin) on the humoral immunity of mice. . Toxicol. Lett. , 23 : 17 – 24 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Tryphonas , H. , Iverson , F. , So , Y. , Nera , E. A. , McGuire , P. F. , O’Grady , L. , Clayson , D. B. and Scott , P. M. 1986 . Effects of deoxynivalenol (vomitoxin) on the humoral and cellular immunity of mice. . Toxicol. Lett. , 30 : 137 – 150 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ueno , Y. 1983 . “ Trichothecenes: Chemical, biological, and toxicological aspects ” . In Trichothecenes , Edited by: Ueno , Y. 135 – 146 . Amsterdam : Elsevier Press .
   Google Scholar
• Ueno , Y. 1984 . Toxicological features of T-2 toxin and related trichothecenes. . Fundam. Appl. Toxicol. , 4 : S124 – S132 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMedGoogle Scholar
• Vesonder , R. F. , Ciegler , A. and Jensen , A. H. 1973 . Isolation of the emetic principle from Fusarium-infected corn . Appl. Microbiol. , 26 : 1008 – 1010 . [PUBMED] [INFOTRIEVE]
   PubMedGoogle Scholar
• Wang , X. , Martindale , J. L. , Liu , Y. and Holbrook , N. J. 1998 . The cellular response to oxidative stress: influences of mitogen- activated protein kinase signalling pathways on cell survival . Biochem. J. , 333 ( Pt 2 ) : 291 – 300 . [PUBMED] [INFOTRIEVE]
   PubMedGoogle Scholar
• Warner , R. L. , Brooks , K. and Pestka , J. J. 1994 . In vitro effects of vomitoxin (deoxynivalenol) on lymphocyte function: enhanced interleukin production and help for IgA secretion. . Food Chem. Toxicol. , 32 : 617 – 625 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Wehner , F. C. , Marasas , W. F. and Thiel , P. G. 1978 . Lack of mutagenicity to Salmonella typhimurium of some Fusarium mycotoxins . Appl. Environ. Microbiol. , 35 : 659 – 662 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Wong , S. S. , Zhou , H. R. , Marin-Martinez , M. L. , Brooks , K. and Pestka , J. J. 1998 . Modulation of IL-1beta, IL-6 and TNF-alpha secretion and mRNA expression by the trichothecene vomitoxin in the RAW 264.7 murine macrophage cell line . Food Chem. Toxicol. , 36 : 409 – 419 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Wong , S. S. , Schwartz , R. C. and Pestka , J. J. 2001 . Superinduction of TNF-α and IL-6 in macrophages by vomitoxin (deoxynivalenol) modulated by mRNA stabilization . Toxicology , 161 : 139 – 149 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Wong , S. S. , Zhou , H. R. and Pestka , J. J. 2002 . Effects of vomitoxin (deoxynivalenol) on the binding of transcription factors AP-1, NF-κB and IL-6 in RAW 264.7 macrophage cells. . J. Toxicol. Environ. Health A , 65 : 1161 – 1180 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Worrell , N. R. , Mallett , A. K. , Cook , W. M. , Baldwin , N. C. and Shepherd , M. J. 1989 . The role of gut micro-organisms in the metabolism of deoxynivalenol administered to rats . Xenobiotica , 19 : 25 – 32 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Yan , D. , Rumbeiha , W. K. and Pestka , J. J. 1998a . Experimental murine IgA nephropathy following passive administration of vomitoxin-induced IgA monoclonal antibodies . Food Chem. Toxicol. , 36 : 1095 – 1106 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Yan , D. , Zhou , H. R. , Brooks , K. H. and Pestka , J. J. 1998b . Role of macrophages in elevated IgA and IL-6 production by Peyer’s patch cultures following acute oral vomitoxin exposure . Toxicol. Appl. Pharmacol. , 148 : 261 – 273 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Yang , G. H. , Jarvis , B. B. , Chung , Y. J. and Pestka , J. J. 2000 . Apoptosis induction by the satratoxins and other trichothecene mycotoxins: Relationship to ERK, p38 MAPK, and SAPK/JNK activation . Toxicol. Appl. Pharmacol. , 164 : 149 – 160 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Yordanova , P. , Islam , Z. and Pestka , J. J. 2003 . Kinetics of deoxynivalenol (vomitoxin) distribution and clearance in the mouse . Toxicologist , 72 ( 1 ) : 253
   Google Scholar
• Yoshino , N. , Takizawa , M. , Akiba , H. , Okumura , H. , Tashiro , F. , Honda , M. and Ueno , Y. 1996 . Transient elevation of intracellular calcium ion levels as an early event in T-2 toxin-induced apoptosis in human promyelotic cell line HL- 60 . Nat. Toxins , 4 : 234 – 241 . [PUBMED] [INFOTRIEVE]
   PubMedGoogle Scholar
• Yoshizawa , T. 1983 . “ Red-mold diseases and natural occurrence in Japan. ” . In Trichothecenes—Chemical, biological, and toxicological aspects , Edited by: Ueno , Y. 195 – 209 . New York : Elsevier .
   Google Scholar
• Yoshizawa , T. and Morooka , N. 1973 . Deoxynivalenol and its monoacetate: New mycotoxins from Fusarium roseum and moldy barley . Agric. Biol. Chem. , 37 : 2933 – 2934 .
   Web of Science ®Google Scholar
• Yoshizawa , T. and Morooka , N. 1974 . Studies on the toxic substances in the infected cereals (III). Acute toxicities of the new trichothecene mycotoxins: Deoxynivalenol and its monoacetate . J. Food Hyg. Soc. Jpn. , 15 : 261 – 269 .
   Google Scholar
• Yoshizawa , T. and Morooka , N. 1977 . “ Trichothecenes in mold infested cereals in Japan. ” . In Mycotoxins in human and animal health , Edited by: Rodricks , J. V. , Hesseltine , C. W. and Mehlman , M. A. 309 – 321 . Park Forest South , IL : Pathotox .
   Google Scholar
• Yoshizawa , T. , Cote , L. M. , Swanson , S. P. and Buck , W. B. 1986 . Confirmation of DOM-1, a de-epoxidation metabolite of deoxynivalenol, in biological fluids of lactating cows. . Agric. Biol. Chem. , 50 : 227 – 229 .
   Web of Science ®Google Scholar
• Yoshizawa , T. , Yamashita , A. and Luo , Y. 1994 . Fumonisin occurrence in corn from high- and low-risk areas for human esophageal cancer in China. . Appl. Environ. Microbiol. , 60 : 1626 – 1629 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Young , J. C. , Fulcher , R. G. , Hayhoe , J. H. , Scott , P. M. and Dexter , J. E. 1984 . Effect of milling and baking on deoxynivalenol (vomitoxin) content of eastern Canadian wheats. . J. Agric. Food Chem. , 32 : 659 – 664 .
   Web of Science ®Google Scholar
• Young , L. G. , McGirr , L. , Valli , V. E. , Lumsden , J. H. and Lun , A. 1983 . Vomitoxin in corn fed to young pigs. . J. Anim. Sci. , 57 : 655 – 664 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Zhou , H. R. , Yan , D. and Pestka , J. J. 1997 . Differential cytokine mRNA expression in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): Dose response and time course . Toxicol. Appl. Pharmacol. , 144 : 294 – 305 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Zhou , H. R. , Yan , D. and Pestka , J. J. 1998 . Induction of cytokine gene expression in mice after repeated and subchronic oral exposure to vomitoxin (deoxynivalenol): Differential toxin-induced hyporesponsiveness and recovery . Toxicol. Appl. Pharmacol. , 151 : 347 – 358 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Zhou , H. R. , Islam , Z. and Pestka , J. J. 2003a . Rapid, sequential activation of mitogen-activated protein kinases and transcription factors precedes proinflammatory cytokine mRNA expression in spleens of mice exposed to the trichothecene vomitoxin . Toxicol. Sci. , 72 : 130 – 142 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Zhou , H. R. , Harkema , J. R. , Hotchkiss , J. A. , Yan , D. , Roth , R. A. and Pestka , J. J. 2000 . Lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol) synergistically induce apoptosis in murine lymphoid organs . Toxicol. Sci. , 53 : 253 – 263 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Zhou , H. R. , Lau , A. S. and Pestka , J. J. 2003b . Role of double-stranded RNA-activated protein kinase (PKR) in deoxynivalenol-induced ribotoxic stress response . Toxicol. Sci. , 74 : 335 – 344 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar