Key Developments in Endocrine Disrupter Research and Human Health

REFERENCES

• Adams , M. M. , Shah , R. A. , Janssen , W. G. and Morrison , J. H. 2001 . Different modes of hippocampal plasticity in response to estrogen in young and aged female rats . Proc. Natl. Acad. Sci. USA , 98 : 8071 – 8076 .
   PubMed Web of Science ®Google Scholar
• Alonso-Magdalena , P. , Laribi , O. , Ropero , A.B. , Fuentes , E. , Ripoll , C. , Soria , B. and Nadal , A. 2005 . Low doses of bisphenol A and diethylstilbestrol impair Ca2+ signals in pancreatic alpha-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans . Environ. Health Perspect. , 113 : 969 – 977 .
   PubMed Web of Science ®Google Scholar
• American Academy of Pediatrics Committee on Genetics . 2000 . Evaluation of the newborn with developmental anomalies of the external genitalia . Pediatrics , 106 : 138 – 142 .
   PubMed Web of Science ®Google Scholar
• Amler , R. W. , Gibertini , M. , Lybarger , J. A. , Hall , A. , Kakolewski , K. , Phifer , B. L. and Olsen , K. L. 1996 . Selective approaches to basic neurobehavioral testing of children in environmental health studies . Neurotoxicol. Teratol. , 18 : 429 – 434 .
   PubMed Web of Science ®Google Scholar
• Anger , W. K. , Rohlman , D. S. , Sizemore , O. J. , Kovera , C. A. , Gibertini , M. and Ger , J. 1996 . Human behavioral assessment in neurotoxicology: Producing appropriate test performance with written and shaping instructions . Neurotoxicol. Teratol. , 18 : 371 – 379 .
   PubMed Web of Science ®Google Scholar
• Anger , W. K. , Letz , R. , Chrislip , D. W. , Frumkin , H. , Hudnell , K. , Russo , J. M. , Chappell , W. and Hutchinson , L. 1994 . Neurobehavioral test methods for environmental health studies of adults . Neurotoxicol. Teratol. , 16 : 489 – 497 .
   PubMed Web of Science ®Google Scholar
• Anway , M. D. and Skinner , M. K. 2006 . Epigenetic transgenerational actions of endocrine disruptors . Endocrinology , 147 : S43 – S49 .
   PubMed Web of Science ®Google Scholar
• Anway , M. D. , Cupp , A. S. , Uzumcu , M. and Skinner , M. K. 2005 . Epigenetic transgenerational actions of endocrine disruptors and male fertility . Science , 308 : 1466 – 1469 .
   PubMed Web of Science ®Google Scholar
• Arnold , J. T. , Le , H. , McFann , K. K. and Blackman , M. R. 2005 . Comparative effects of DHEA vs. testosterone, dihydrotestosterone, and estradiol on proliferation and gene expression in human LNCaP prostate cancer cells . Am. J. Physiol. Endocrinol. Metab. , 288 : E573 – E584 .
   PubMed Web of Science ®Google Scholar
• Ayotte , P. , Muckle , G. , Jacobson , J. L. , Jacobson , S. W. and Dewailly , E. 2003 . Assessment of pre- and postnatal exposure to polychlorinated biphenyls: Lessons from the Inuit cohort study . Environ. Health Perspect. , 111 : 1253 – 1258 .
   PubMed Web of Science ®Google Scholar
• Baillie-Hamilton , P. F. 2002 . Chemical toxins: A hypothesis to explain the global obesity epidemic . J. Altern Complement Med. , 8 : 185 – 192 .
   PubMed Web of Science ®Google Scholar
• Baken , K. A. , Vandebriel , R. J. , Pennings , J. L. , Kleinjans , J. C. and van Loveren , H. 2007 . Toxicogenomics in the assessment of immunotoxicity . Methods , 41 : 132 – 141 .
   PubMed Web of Science ®Google Scholar
• Balog , R. P. , de Souza , Y. E. , Tang , H. M. , DeMasellis , G. M. , Gao , B. , Avila , A. , Gaban , D. J. , Mittelman , D. , Minna , J. D. , Luebke , K. J. and Garner , H. R. 2002 . Parallel assessment of CpG methylation by two-color hybridization with oligonucleotide arrays . Anal. Biochem. , 309 : 301 – 310 .
   PubMed Web of Science ®Google Scholar
• Barlow , N. J. , McIntyre , B. S. and Foster , P. M. 2004 . Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate . Toxicol. Pathol. , 32 : 79 – 90 .
   PubMed Web of Science ®Google Scholar
• Barros , R. P. , Machado , U. F. and Gustafsson , J. 2006a . Estrogen receptors: New players in diabetes mellitus . Trends Mol. Med. , 12 : 425 – 431 .
   PubMed Web of Science ®Google Scholar
• Barros , R. P. , Machado , U. F. , Warner , M. and Gustafsson , J. A. 2006b . Muscle GLUT4 regulation by estrogen receptors ERb and ERa . Proc. Natl. Acad. Sci. USA , 103 : 1605 – 1608 .
   PubMed Web of Science ®Google Scholar
• Banerjee , B. D. , Seth , V. and Ahmed , R. S. 2001 . Pesticide-induced oxidative stress: perspectives and trends . Rev. Environ. Health , 16 : 1 – 40 .
   PubMedGoogle Scholar
• Basha , M. R. , Wei , W. , Bakheet , S. A. , Benitez , N. , Siddiqi , H. K. , Ge , Y. W. , Lahiri , D. K. and Zawia , NH. 2005 . The fetal basis of amyloidogenesis: Exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain . J. Neurosci. , 25 : 823 – 829 .
   PubMed Web of Science ®Google Scholar
• Bertazzi , P. A. , Bernucci , I. , Brambilla , G. , Consonni , D. and Pesatori , A. C. 1998 . The Seveso studies on early and long-term effects of dioxin exposure: A review . Environ. Health Perspect. , 106 : 625 – 633 .
   PubMed Web of Science ®Google Scholar
• Bird , A. P. 1986 . CpG-rich islands and the function of DNA methylation . Nature , 321 : 209 – 213 .
   PubMed Web of Science ®Google Scholar
• Bjornholm , M. and Zierath , J. R. 2005 . Insulin signal transduction in human skeletal muscle: Identifying the defects in Type II diabetes . Biochem. Soc. Transact. , 33 : 354 – 357 .
   PubMed Web of Science ®Google Scholar
• Boisen , K. A. , Main , K. M. , Rajpert-De Meyts , E. and Skakkebaek , N. E. 2001 . Are male reproductive disorders a common entity? The testicular dysgenesis syndrome . Ann. NY Acad. Sci. , 948 : 90 – 99 .
   PubMed Web of Science ®Google Scholar
• Bloom , F. E. , Morrison , J. H. and Young , W. G. 2006 . Neuroinformatics: A new tool for studying the brain . J. Affect. Disord. , 92 : 133 – 138 .
   PubMed Web of Science ®Google Scholar
• Bolognesi , C. 2003 . Genotoxicity of pesticides: A review of human biomonitoring studies . Mutat. Res. , 543 : 251 – 272 .
   PubMed Web of Science ®Google Scholar
• Boser , B. E. , Guyon , I. M. and Vapnik , V. N. . A training algorithm for optimal margin classifiers . Proceedings of the 5th Annual International Conference on Computational Learning Theory . July 27–29 1992 , Pittsburgh, Pennsylvania. pp. 144 – 152 . Pittsburgh, PA : ACM Press .
   Google Scholar
• Boverhof , D. R. and Zacharewski , T. R. 2006 . Toxicogenomics in risk assessment: Applications and needs . Toxicol. Sci. , 89 : 352 – 360 .
   PubMed Web of Science ®Google Scholar
• Boyd , J. , Takahashi , H. , Waggoner , S. E. , Jones , L. A. , Hajek , R. A. , Wharton , J. T. , Liu , F. , Fujino , T. , Barrett , J. C. and McLachlan , J. A. 1996 . Molecular genetic analysis of diethylstilbestrol-associated clear cell adenocarcinomas of the vagina and cervix . Cancer , 77 : 507 – 513 .
   PubMed Web of Science ®Google Scholar
• Bryzgalova , G. , Gao , H. , Ahren , B. , Zierath , J.R. , Galuska , D. , Steiler , T. L. , Dahlman-Wright , K. , Nilsson , S. , Gustafsson , J. A. , Efendic , S. and Khan , A. 2006 . Evidence that oestrogen receptor-alpha plays an important role in the regulation of glucose homeostasis in mice: Insulin sensitivity in the liver . Diabetologia , 49 : 588 – 597 .
   PubMed Web of Science ®Google Scholar
• Buchanan , T. A. , Metzger , B. E. , Freinkel , N. and Bergman , R. N. 1990 . Insulin sensitivity and B-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes . Am. J. Obstet. Gynecol. , 162 : 1008 – 1014 .
   PubMed Web of Science ®Google Scholar
• Bulayeva , N. N. , Gametchu , B. and Watson , C. S. 2004 . Quantitative measurement of estrogen-induced ERK-1 and 2 activation via multiple membrane initiated signaling pathways . Steroids , 69 : 181 – 192 .
   PubMed Web of Science ®Google Scholar
• Bulayeva , N. N. and Watson , C. S. 2004 . Xenoestrogen-induced ERK-1 and ERK-2 activation via multiple membrane-initiated signaling pathways . Environ. Health Perspect. , 112 : 1481 – 1487 .
   PubMed Web of Science ®Google Scholar
• Bulera , S. J. , Eddy , S. M. , Ferguson , E. , Jatkoe , T. A. , Reindel , J. F. , Bleavins , M. R. and De La Iglesia , F. A. 2001 . RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays . Hepatology , 33 : 1239 – 1258 .
   PubMed Web of Science ®Google Scholar
• Callegari , C. , Everett , S. , Ross , M. and Brasel , J. A. 1987 . Anogenital ratio: Measure of fetal virilization in premature and fullterm newborn infants . J. Pediatr. , 111 : 240 – 243 .
   PubMed Web of Science ®Google Scholar
• Carani , C. , Qin , K. , Simoni , M. , Faustini-Fustini , M. , Serpente , S. , Boyd , J. , Korach , K. S. and Simpson , E. R. 1997 . Effect of testosterone and estradiol in a man with aromatase deficiency . N. Engl. J. Med. , 337 : 91 – 95 .
   PubMed Web of Science ®Google Scholar
• Case , A. M. and Reid , R. L. 2001 . Menstrual cycle effects on common medical conditions . Compr. Ther. , 27 : 65 – 71 .
   PubMedGoogle Scholar
• Centers for Disease Control . 1988 . Health status of Vietnam veterans. Physical health . J. Am. Med. Assoc. , 259 : 2708 – 2714 .
   Web of Science ®Google Scholar
• Chana , A. , Concejero , M. A. , de Frutos , M. , Gonzalez , M. J. and Herradon , B. 2002 . Computational studies on biphenyl derivatives. Analysis of the conformational mobility, molecular electrostatic potential, and dipole moment of chlorinated biphenyl: Searching for the rationalization of the selective toxicity of polychlorinated biphenyls (PCBs) . Chem. Res. Toxicol. , 15 : 1514 – 1526 .
   PubMed Web of Science ®Google Scholar
• Chang , H. S. , Anway , M. D. , Rekow , S. S. and Skinner , M. K. 2006 . Transgenerational epigenetic imprinting of the male germline by endocrine disruptor exposure during gonadal sex determination . Endocrinology , 147 : 5524 – 5541 .
   PubMed Web of Science ®Google Scholar
• Choi , S. M. , Yoo , S. D. and Lee , B. M. 2004 . Toxicological characteristics of endocrine-disrupting chemicals: Developmental toxicity, carcinogenicity and mutagenicity . J. Toxicol Environ. Health B , 7 : 1 – 24 .
   PubMed Web of Science ®Google Scholar
• Cisneros , F. J. 2004 . DNA methylation and male infertility . Front. Biosci. , 9 : 1189 – 1200 .
   PubMed Web of Science ®Google Scholar
• Clark , J. H. and Mani , S. K. 1994 . “ Actions of ovarian steroid hormones ” . In The physiology of reproduction , 2nd , Edited by: Knobil , E. and Neill , J. Vol. 1 , 1011 – 1059 . New York : Raven Press .
   Google Scholar
• Clark , R. L. , Antonello , J. M. , Grossman , S. J. , Wise , L. D. , Anderson , C. , Bagdon , W. J. , Prahalada , S. , MacDonald , J. S. and Robertson , R. T. 1990 . External genitalia abnormalities in male rats exposed in utero to finasteride, a 5 alpha-reductase inhibitor . Teratology , 42 : 91 – 100 .
   PubMedGoogle Scholar
• Collison , M. , Campbell , I. W. , Salt , I. P. , Dominiczak , A. F. , Connell , J. M. , Lyall , H. and Gould , G. W. 2000 . Sex hormones induce insulin resistance in 3T3-L1 adipocytes by reducing cellular content of IRS proteins . Diabetologia , 43 : 1374 – 1380 .
   PubMed Web of Science ®Google Scholar
• Colosio , C. , Tiramani , M. and Maroni , M. 2003 . Neurobehavioral effects of pesticides: State of the art . Neurotoxicology , 24 : 577 – 591 .
   PubMed Web of Science ®Google Scholar
• Crews , D. , Gore , A. C. , Hsu , T. S. , Dangleben , N. L. , Spinetta , M. , Schallert , T. , Anway , M. D. and Skinner , M. K. 2007 . Transgenerational epigenetic imprints on mate preference . Proc. Natl. Acad. Sci. USA , 104 : 5942 – 5946 .
   PubMed Web of Science ®Google Scholar
• Crews , D. and McLaughlan , J. A. 2006 . Epigenetics, evolution, endocrine disruption, health and disease . Endocrinology , 147 : S4 – S10 .
   PubMed Web of Science ®Google Scholar
• Cunningham , M. L. , Irwin , R. and Boorman , G. 2003 . Tox/path team takes on differential gene expression . Environ. Health Perspect. , 111 : A814 – A815 .
   PubMed Web of Science ®Google Scholar
• Dang , Z. C. , Audinot , V. , Papapoulos , S. E. , Boutin , J. A. and Lowik , C. W. 2003 . Peroxisome proliferator-activated receptor gamma (PPAR gamma) as a molecular target for the soy phytoestrogen genistein . J. Biol. Chem. , 278 : 962 – 967 .
   PubMed Web of Science ®Google Scholar
• Danilovich , N. , Babu , P. S. , Xing , W. , Gerdes , M. , Krishnamurthy , H. and Sairam , M. R. 2000 . Estrogen deficiency, obesity, and skeletal abnormalities in follicle-stimulating hormone receptor knockout (FORKO) female mice . Endocrinology , 141 : 4295 – 4308 .
   PubMed Web of Science ®Google Scholar
• Daston , G. P. and Naciff , J. M. 2005 . Gene expression changes related to growth and differentiation in the fetal and juvenile reproductive system of the female rat: evaluation of microarray results . Reprod. Toxicol. , 19 : 381 – 394 .
   PubMed Web of Science ®Google Scholar
• Daston , G. P. , Cook , J. C. and Kavlock , R. J. 2003 . Uncertainties for endocrine disrupters: Our view on progress . Toxicol. Sci. , 74 : 245 – 252 .
   PubMed Web of Science ®Google Scholar
• DeRosa , C. , Richter , P. , Pohl , H. and Jones , D. E. 1998 . Environmental exposures that affect the endocrine system: public health implications . J. Toxicol. Environ. Health B , 1 : 3 – 26 .
   PubMed Web of Science ®Google Scholar
• Dieudonne , M.N. , Leneveu , M.C. , Giudicelli , Y. and Pecquery , R. 2004 . Evidence for functional estrogen receptors alpha and beta in human adipose cells: Regional specificities and regulation by estrogens . Am J. Physiol Cell Physiol. , 286 : C655 – C661 .
   PubMed Web of Science ®Google Scholar
• Docterman , K. E. and Smith , S. M. 2002 . Of meis and men: Lessons from a microarray study of teratogen action . Teratology , 66 : 217 – 223 .
   PubMedGoogle Scholar
• Dodds , E. C. , Goldberg , L. , Lawson , W. and Robinson , R. 1938 . Estrogenic activity of certain synthetic compounds . Nature , 141 : 247 – 248 .
   Google Scholar
• Dolinoy , D. , Weidman , J. R. , Waterland , R. A. and Jirtle , R. L. 2006 . Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome . Environ. Health Perspect. , 114 : 567 – 572 .
   PubMed Web of Science ®Google Scholar
• Dowling , V. A. and Sheehan , D. 2006 . Proteomics as a route to identification of toxicity targets in environmental toxicology . Proteomics , 6 : 5597 – 604 .
   PubMed Web of Science ®Google Scholar
• Drake , A. J. and Walker , B. R. 2004 . The intergenerational effects of fetal programming: Non-genomic mechanisms for the inheritance of low birth weight and cardiovascular risk . J. Endocrinol. , 180 : 1 – 16 .
   PubMed Web of Science ®Google Scholar
• Duggan , D. J. , Bittner , M. , Chen , Y. , Meltzer , P. and Trent , J. M. 1999 . Expression profiling using cDNA microarrays . Nat. Genet. , 21 : 10 – 14 .
   PubMed Web of Science ®Google Scholar
• Dunaif , A. , Segal , K. R. , Futterweit , W. and Dobrjansky , A. 1989 . Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome . Diabetes , 38 : 1165 – 1174 .
   PubMed Web of Science ®Google Scholar
• Dussault , J. H. and Ruel , J. 1987 . Thyroid hormones and brain development . Annu. Rev. Physiol. , 49 : 321 – 334 .
   PubMed Web of Science ®Google Scholar
• Eckerman , D. A. , Gimenes , L. S. , de Souza , R. C. , Lopes Galvão , P. R. , Sarcinelli , P. N. and Chrisman , J. R. 2007 . Age related effects of pesticide exposure on neurobehavioral performance of adolescent farm workers in Brazil . Neurotoxicol. Teratol. , 29 : 164 – 175 .
   PubMed Web of Science ®Google Scholar
• EDSTAC. 1998. Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC) final report. http://www.epa.gov/endo/pubs/edspoverview/finalrpt.htm (Accessed: 17 February 2008 ).
   Google Scholar
• Elrick , M. M. , Walgren , J. L. , Mitchell , M. D. and Thompson , D. C. 2006 . Proteomics: Recent applications and new technologies . Basic Clin. Pharmacol. Toxicol. , 98 : 432 – 441 .
   PubMed Web of Science ®Google Scholar
• Ema , M. , Miyawaki , E. , Hirose , A. and Kamata , E. 2003 . Decreased anogenital distance and increased incidence of undescended testes in fetuses of rats given monobenzyl phthalate, a major metabolite of butyl benzyl phthalate . Reprod. Toxicol. , 17 : 407 – 412 .
   PubMed Web of Science ®Google Scholar
• Eriksson , L. , Jaworska , J. , Worth , A. , Cronin , M. , McDowell , R. M. and Gramatica , P. 2003 . Methods for reliability and uncertainty assessment and for applicability evaluations of classification- and regression-based QSARs . Environ. Health Perspect. , 111 : 1361 – 1375 .
   PubMed Web of Science ®Google Scholar
• Esteller , M. and Herman , J. G. 2002 . Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours . J. Pathol. , 196 : 1 – 7 .
   PubMed Web of Science ®Google Scholar
• Farach-Carson , M. C. and Davis , P. J. 2003 . Steroid hormone interactions with target cells: Cross talk between membrane and nuclear pathways . J. Pharmacol. Exp. Ther. , 307 : 839 – 845 .
   PubMed Web of Science ®Google Scholar
• Faustini-Fustini , M. , Rochira , V. and Carani , C. 1999 . Oestrogen deficiency in men: Where are we today? . Eur. J. Endocrinol. , 140 : 111 – 129 .
   PubMed Web of Science ®Google Scholar
• Ferre , P. 2004 . The biology of peroxisome proliferator-activated receptors: Relationship with lipid metabolism and insulin sensitivity . Diabetes , 53 : S43 – S50 .
   PubMed Web of Science ®Google Scholar
• Fisher , C. R. , Graves , K. H. , Parlow , A. F. and Simpson , E. R. 1998 . Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene . Proc. Natl. Acad. Sci. USA , 95 : 6965 – 6970 .
   PubMed Web of Science ®Google Scholar
• Fisher , J.S . 2004 . Environmental anti-androgens and male reproductive health: Focus on phthalates and testicular dysgenesis syndrome . Reproduction , 127 : 305 – 315 .
   PubMed Web of Science ®Google Scholar
• Foster , P. M. and McIntyre , B. S. 2002 . Endocrine active agents: implications of adverse and non-adverse changes . Toxicol. Pathol. , 30 : 59 – 65 .
   PubMed Web of Science ®Google Scholar
• Foster , P. M. , Mylchreest , E. , Gaido , K. W. and Sar , M. 2001 . Effects of phthalate esters on the developing reproductive tract of male rats . Hum. Reprod. Update , 7 : 231 – 235 .
   PubMed Web of Science ®Google Scholar
• Foster , W. G. and Agzarian , J. 2008 . Toward less confusing terminology in endocrine disruptor research . J. Toxicol. Environ. Health B , 11 in press
   Web of Science ®Google Scholar
• Foster , W. G. 1998 . Endocrine disruptors and development of the reproductive system in the fetus and children: Is there cause for concern? . Can J. Public Health , 89 : S37 – 41 . S52 S41 – 46 .
   PubMed Web of Science ®Google Scholar
• Francois , E. , Wang , D.-Y. , Fulthorpe , R. , Liss , S. and Edwards , E. A. 2003 . DNA microarrays for detecting endocrine-disrupting compounds . Biotechnol. Adv. , 22 : 17 – 26 .
   PubMed Web of Science ®Google Scholar
• Freeman , K. 2004 . Toxicogenomics data: The road to acceptance . Environ. Health Perspect. , 112 : A678 – A685 .
   PubMedGoogle Scholar
• Fujiyoshi , P. T. , Michalek , J. E. and Matsumura , F. 2006 . Molecular epidemiologic evidence for diabetogenic effects of dioxin exposure in U.S. Air Force veterans of the Vietnam War . Enviro.n Health Perspect. , 114 : 1677 – 1683 .
   PubMed Web of Science ®Google Scholar
• Gaido , K. W. , Leonard , L. S. , Maness , S. C. , Hall , J. M. , McDonnell , D. P. , Saville , B. and Safe , S. 1999 . Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta . Endocrinology , 140 : 5746 – 5753 .
   PubMed Web of Science ®Google Scholar
• Garvey , W. T. , Maianu , L. , Zhu , J. H. , Hancock , J. A. and Golichowski , A. M. 1993 . Multiple defects in the adipocyte glucose transport system cause cellular insulin resistance in gestational diabetes. Heterogeneity in the number and a novel abnormality in subcellular localization of GLUT4 glucose transporters . Diabetes , 42 : 1773 – 1785 .
   PubMed Web of Science ®Google Scholar
• Gitan , R. S. , Shi , H. , Chen , C. M. , Yan , P. S. and Huang , T. H. 2002 . Methylation-specific oligonucleotide microarray: A new potential for high-throughput methylation analysis . Genome Res. , 12 : 158 – 164 .
   PubMed Web of Science ®Google Scholar
• Grandjean , P. , Weihe , P. , Burse , V. W. , Needham , L. L. , Storr-Hansen , E. , Heinzow , B. , Debes , F. , Murata , K. , Simonsen , H. , Ellefsen , P. , Budtz-Jorgensen , E. , Keiding , N. and White , R. F. 2001 . Neurobehavioral deficits associated with PCB in 7-year-old children prenatally exposed to seafood neurotoxicants . Neurotoxicol. Teratol. , 23 : 305 – 317 .
   PubMed Web of Science ®Google Scholar
• Gray , L. E. , Ostby , J. , Furr , J. , Price , M. , Veeramachaneni , D. N. R. and Parks , L. 2000 . Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat . Toxicol. Sci. , 58 : 350 – 365 .
   PubMed Web of Science ®Google Scholar
• Gray , L. E. , Ostby , J. , Cooper , R. L. and Kelce , W. R. 1999 . The estrogenic and antiandrogenic pesticide methoxychlor alters the reproductive tract and behavior without affecting pituitary size or LH and prolactin secretion in male rats . Toxicol. Ind. Health , 15 : 37 – 47 .
   PubMed Web of Science ®Google Scholar
• Gray , L. E. , Ostby , J. S. and Kelce , W. R. 1994 . Developmental effects of an environmental antiandrogen: The fungicide vinclozolin alters sex differentiation of the male rats . Toxicol. Appl. Pharmacol. , 129 : 46 – 52 .
   PubMed Web of Science ®Google Scholar
• Grün , F. , Watanabe , H. , Zamanian , Z. , Maeda , L. , Arima , K. , Chubacha , R. , Gardiner , D. M. , Kanno , J. , Iguchi , T. and Blumberg , B. 2006 . Endocrine disrupting organotin compounds are potent inducers of adipogenesis in vertebrates . Mol. Endocrinol. , 20 : 2141 – 2155 .
   PubMed Web of Science ®Google Scholar
• Grün , F. and Blumberg , B. 2006 . Environmental obesogens: Organotins and endocrine disruption via nuclear receptor signaling . Endocrinology , 147 : S50 – S55 .
   PubMed Web of Science ®Google Scholar
• Hales , C. N. and Barker , D. J. 2001 . The thrifty phenotype hypothesis . Br. Med. Bull. , 60 : 5 – 20 .
   PubMed Web of Science ®Google Scholar
• Halle , M. , Berg , A. , Northoff , H. and Keul , J. 1998 . Importance of TNF-alpha and leptin in obesity and insulin resistance: A hypothesis on the impact of physical exercise . Exercise Immunol. Rev. , 4 : 77 – 94 .
   PubMed Web of Science ®Google Scholar
• Halliwell , B. 2002 . Effect of diet on cancer development: Is oxidative DNA damage a biomarker? . Free Radic. Biol. Med. , 32 : 968 – 974 .
   PubMed Web of Science ®Google Scholar
• Hamadeh , H. K. , Bushel , P. R. , Jayadev , S. , DiSorbo , O. , Bennett , L. , Li , L. , Tennant , R. , Stoll , R. , Barrett , J. C. , Paules , R. S. , Blanchard , K. and Afshari , C. A. 2002 . Prediction of compound signature using high density gene expression profiling . Toxicol. Sci. , 67 : 232 – 240 .
   PubMed Web of Science ®Google Scholar
• Harris , K. M. 1999 . Structure, development, and plasticity of dendritic spines . Curr. Opin. Neurobiol. , 9 : 343 – 348 .
   PubMed Web of Science ®Google Scholar
• Hayes , K. R. and Bradfield , C. A. 2005 . Advances in toxicogenomics . Chem. Res. Toxicol. , 18 : 403 – 414 .
   PubMed Web of Science ®Google Scholar
• Haynes , J. D. and Rees , G. 2006 . Decoding mental states from brain activity in humans . Nat. Rev. Neurosci. , 7 : 523 – 534 .
   PubMed Web of Science ®Google Scholar
• Heindel , J. J. 2003 . Endocrine disruptors and the obesity epidemic . Toxicol. Sci. , 76 : 247 – 249 .
   PubMed Web of Science ®Google Scholar
• Heindel , J. J. 2005 . The fetal basis of adult disease: Role of environmental exposures—Introduction . Birth Defects Res. A Clin. Mol. Teratol. , 73 : 131 – 132 .
   PubMedGoogle Scholar
• Heine , P. A. , Taylor , J. A. , Iwamoto , G. A. , Lubahn , D. B. and Cooke , P. S. 2000 . Increased adipose tissue in male and female estrogen receptor-α knockout mice . Proc Natl. Acad. Sci. USA , 97 : 12729 – 12734 .
   PubMed Web of Science ®Google Scholar
• Henley , D. V. and Korach , K. S. 2006 . Endocrine-disrupting chemicals use distinct mechanisms of action to modulate endocrine system function . Endocrinology , 147 : S25 – S32 .
   Web of Science ®Google Scholar
• Henriksen , G. L. , Ketchum , N. S. , Michalek , J. E. and Swaby , J. A. 1997 . Serum dioxin and diabetes mellitus in veterans of Operation Ranch Hand . Epidemiology , 8 : 252 – 258 .
   PubMed Web of Science ®Google Scholar
• Hines , A. , Oladiran , G. S. , Bignell , J. P. , Stentiford , G. D. and Viant , M. R. 2007 . Direct sampling of organisms from the field and knowledge of their phenotype: Key recommendations for environmental metabolomics . Environ. Sci. Technol. , 41 : 3375 – 3381 .
   PubMed Web of Science ®Google Scholar
• Hiroi , H. , Tsutsumi , O. , Momoeda , M. , Takai , Y. , Osuga , Y. and Taketani , Y. 1999 . Differential interactions of bisphenol A and 17 beta-estradiol with estrogen receptor alpha (ER alpha) and ER beta . Endocrin. J. , 46 : 773 – 778 .
   PubMed Web of Science ®Google Scholar
• Holsapple , M. P. 2003 . Developmental immunotoxicology testing: A review . Toxicology , 185 : 193 – 203 .
   PubMed Web of Science ®Google Scholar
• Hood , E. 2007 . TRC: Mission accomplished . Environ. Health Perspect. , 115 : A81 – A82 .
   Web of Science ®Google Scholar
• Huerta , M. , Koslow , S. and Leshner , A. 1993 . The Human Brain Project: An international resource . Trends Neurosci. , 16 : 436 – 438 .
   PubMed Web of Science ®Google Scholar
• Huisman , M. , Koopman-Esseboom , C. , Lanting , C. I. , van der Paauw , C. G. , Tuinstra , L. G. , Fidler , V. , Weisglas-Kuperus , N. , Sauer , P. J. , Boersma , E. R. and Touwen , B. C. 1995 . Neurological condition in 18-month-old children perinatally exposed to polychlorinated biphenyls and dioxins . Early Hum. Dev. , 43 : 165 – 176 .
   PubMed Web of Science ®Google Scholar
• Iguchi , T. , Watanabe , H. and Katsu , Y. 2006 . Application of ecotoxicogenomics for studying endocrine disruption in vertebrates and invertebrates . Environ. Health Perspect. , 114 : 101 – 105 .
   PubMed Web of Science ®Google Scholar
• Iguchi , T. , Fukazawa , Y. and Bern , H. A. 1995 . Effects of sex hormones on oncogene expression in the vagina and on the development of sexual dimorphism of the pelvis and anococcygeus muscle in the mouse . Environ. Health Perspect. , 103 : 79 – 82 .
   PubMed Web of Science ®Google Scholar
• Imperato-McGinley , J. , Sanchez , R. S. , Spencer , J. R. , Yee , B. and Vaughan , E. D. 1992 . Comparison of the effects of the 5α-reductase inhibitor finasteride and the antiandrogen flutamide on prostate and genital differentiation: Dose-response studies . Endocrinology , 131 : 1149 – 1156 .
   PubMed Web of Science ®Google Scholar
• Iregren , A. , Gamberale , F. and Kjellberg , A. 1996 . SPES: A psychological test system to diagnose environmental hazards. Swedish Performance Evaluation System . Neurotoxicol. Teratol. , 18 : 485 – 491 .
   PubMed Web of Science ®Google Scholar
• Inoue , T. and Pennie , W. D. , eds. 2002 . Toxicogenomics , Tokyo : Springer-Verlag .
   Google Scholar
• Jiang , Y. H. , Bressler , J. and Beaudet , A.L. 2004 . Epigenetics and human disease . Ann. Rev. Genomics Hum. Genet. , 5 : 479 – 510 .
   PubMed Web of Science ®Google Scholar
• Johnson , B. L. 1987 . Prevention of neurotoxic illness in working populations , New York : John Wiley & Sons .
   Google Scholar
• Johnson , C. D. , Balagurunathan , Y. , Tadesse , M. G. , Falahatpisheh , M. H. , Brun , M. , Walker , M. K. , Dougherty , E. R. and Ramos , K. S. 2004 . Unraveling gene–gene interactions regulated by ligands of the aryl hydrocarbon receptor . Environ. Health Perspect. , 112 : 403 – 412 .
   PubMed Web of Science ®Google Scholar
• Jones , P. A. and Takai , D. 2001 . The role of DNA methylation in mammalian epigenetics . Science , 293 : 1068 – 1070 .
   PubMed Web of Science ®Google Scholar
• Jones , M. E. , Thorburn , A. W. , Britt , K. L. , Hewitt , K. N. , Wreford , N. G. , Proietto , J. , Oz , O. K. , Leury , B. J. , Robertson , K. M. , Yao , S. and Simpson , E. R. 2000 . Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity . Proc. Natl. Acad. Sci. USA , 97 : 12735 – 12740 .
   PubMed Web of Science ®Google Scholar
• Kaaja , R. J. and Greer , I. A. 2005 . Manifestations of chronic disease during pregnancy . J. Am. Med. Assoc. , 294 : 2751 – 2757 .
   PubMed Web of Science ®Google Scholar
• Kamel , F. and Hoppin , J. A. 2004 . Association of pesticide exposure with neurologic dysfunction and disease . Environ. Health Perspect. , 112 : 950 – 958 .
   PubMed Web of Science ®Google Scholar
• Kao , C. M. 1999 . Functional genomic technologies: creating new paradigms for fundamental and applied biology . Biotechnol. Prog. , 15 : 304 – 311 .
   PubMed Web of Science ®Google Scholar
• Kelce , W. R. , Lambright , C. , Gray , L. E. and Roberts , K. 1997 . Vinclozolin and p, p′-DDE alter androgen-dependent gene expression: In vivo confirmation of an androgen receptor mediated mechanism . Toxicol. Appl. Pharmacol. , 142 : 192 – 200 .
   PubMed Web of Science ®Google Scholar
• Kelce , W. R. , Stone , C. R. , Laws , S. C. , Gray , L. E. , Kemppainen , J. A. and Wilson , E. M. 1995 . The persistent DDT metabolite p, p′-DDE is a potent androgen receptor antagonist . Nature , 375 : 581 – 585 .
   PubMed Web of Science ®Google Scholar
• Kim , H. S. , Kim , T. S. , Shin , J.-H. , Moon , H. J. , Kang , I. H. , Kim , I. Y. , Oh , J. Y. and Han , S. Y. 2004 . Neonatal exposure to di(n-butyl) phthalate (DBP) alters male reproductive tract development . J. Toxicol. Environ. Health A , 67 : 2045 – 2060 .
   PubMed Web of Science ®Google Scholar
• Kim , J. S. , Lim , H. S. , Cho , S. I. , Cheong , H. K. and Lim , M. K. 2003 . Impact of Agent Orange exposure among Korean Vietnam veterans . Ind. Health , 41 : 149 – 157 .
   PubMed Web of Science ®Google Scholar
• Kirkland , D. J. and Muller , L. 2000 . Interpretation of the biological relevance of genotoxicity test results: The importance of thresholds . Mutat. Res. , 464 : 137 – 147 .
   PubMed Web of Science ®Google Scholar
• Klip , H. , Verloop , J. , van Gool , J. D. , Koster , M. E. , Burger , C. W. and van Leeuwen , F. E. 2002 . Hypospadias in sons of women exposed to diethylstilbestrol in utero: A cohort study . Lancet , 359 : 1102 – 1107 .
   PubMed Web of Science ®Google Scholar
• Ko , M. S. 2001 . Embryogenomics: developmental biology meets genomics . Trends Biotechnol. , 19 : 511 – 518 .
   PubMed Web of Science ®Google Scholar
• Kondo , A. , Li , W. , Nakagawa , T. , Nakano , M. , Koyama , N. , Wang , X. , Gu , J. , Miyoshi , E. and Taniguchi , N. 2006 . From glycomics to functional glycomics of sugar chains: Identification of target proteins with functional changes using gene targeting mice and knock down cells of FUT8 as examples . Biochim. Biophys. Acta , 1764 : 1881 – 1889 .
   PubMed Web of Science ®Google Scholar
• Kuiper , G. G. , Lemmen , J. G. , Carlsson , B. , Corton , J. C. , Safe , S. H. , van der Saag , P. T. , van der Burg , B. and Gustafsson , J. A. 1998 . Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta . Endocrinology , 139 : 4252 – 4263 .
   PubMed Web of Science ®Google Scholar
• Kuiper , G. G. , Enmark , E. , Pelto-Huikko , M. , Nilsson , S. and Gustafsson , J. A. 1996 . Cloning of a novel receptor expressed in rat prostate and ovary . Proc. Natl. Acad. Sci. USA , 93 : 5925 – 5930 .
   PubMed Web of Science ®Google Scholar
• Kultima , K. , Nyström , A. M. , Scholz , B. , Gustafson , A. L. , Dencker , L. and Stigson , M. 2004 . Valproic acid teratogenicity: A toxicogenomics approach . Environ. Health Perspect. , 112 : 1225 – 1235 .
   PubMed Web of Science ®Google Scholar
• LaBaer , J. and Ramachandran , N. 2005 . Protein microarrays as tools for functional proteomics . Curr. Opin. Chem. Biol. , 9 : 14 – 19 .
   PubMed Web of Science ®Google Scholar
• Lee , B. M. and Koo , H. J. 2007 . Hershberger assay for antiandrogenic effects of phthalates . J. Toxicol. Environ. Health A , 70 : 1365 – 1370 .
   PubMed Web of Science ®Google Scholar
• Letz , R. 1990 . “ The Neurobehavioral Evaluation System: An international effort ” . In Advances in neurobehavioral toxicology: Applications in environmental and occupational health , Edited by: Johnson , B. L. 189 – 201 . Chelsea, MI : Lewis .
   Google Scholar
• Li , E. , Bestor , T. H. and Jaenisch , R. 1992 . Targeted mutation of the DNA methyltransferase gene results in embryonic lethality . Cell , 69 : 915 – 926 .
   PubMed Web of Science ®Google Scholar
• Li , S. , Hansman , R. , Newbold , R. , Davis , B. , McLachlan , J. A and Barrett , J. C. 2003a . Neonatal diethylstilbestrol exposure induces persistent elevation of c-fos expression and hypomethylation in its exon-4 in mouse uterus . Mol. Carcinogen. , 38 : 78 – 84 .
   PubMed Web of Science ®Google Scholar
• Li , S. , Hursting , S. D. , Davis , B. J. , McLachlan , J. A. and Barrett , J. C. 2003b . Environmental exposure, DNA methylation, and gene regulation: Lessons from diethylstilbesterol-induced cancers . Ann. NY Acad. Sci. , 983 : 161 – 169 .
   PubMed Web of Science ®Google Scholar
• Li , S. , Washburn , K. A. , Moore , R. , Uno , T. , Teng , C. , Newbold , R. R. , McLachlan , J. A. and Negishi , M. 1997 . Developmental exposure to diethylstilbestrol elicits demethylation of estrogen-responsive lactoferrin gene in mouse uterus . Cancer Res. , 57 : 4356 – 4359 .
   PubMed Web of Science ®Google Scholar
• Lin , C. Y. , Viant , M. R. and Tjeerdema , R. S. 2006 . Metabolomics: Methodologies and applications in the environmental sciences . J. Pestic. Sci. , 31 : 245 – 251 .
   Web of Science ®Google Scholar
• Lister , A. L. and Van der Kraak , G. J. 2001 . Endocrine disruption: Why is it so complicated? . Water Qual. Res. J. Can. , 36 : 175 – 190 .
   Web of Science ®Google Scholar
• Livingstone , C. and Collison , M. 2002 . Sex steroids and insulin resistance . Clin. Sci. (Lond.) , 102 : 151 – 166 .
   PubMed Web of Science ®Google Scholar
• Longnecker , M. P. and Michalek , J. E. 2000 . Serum dioxin level in relation to diabetes mellitus among Air Force veterans with background levels of exposure . Epidemiology , 11 : 44 – 48 .
   PubMed Web of Science ®Google Scholar
• Lopez-Barea , J. and Gomez-Ariza , J. L. 2006 . Environmental proteomics and metabolomics . Proteomics. , 6 : S51 – S62 .
   Google Scholar
• Lund , A. H. and van Lohuizen , M. 2004 . Epigenetics and cancer . Genes Dev. , 18 : 2315 – 2335 .
   PubMed Web of Science ®Google Scholar
• Maness , S. C. , McDonnell , D. P. and Gaido , K. W. 1998 . Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells . Toxicol. Appl. Pharmacol. , 151 : 135 – 142 .
   PubMed Web of Science ®Google Scholar
• Masuno , H. , Kidani , T. , Sekiya , K. , Sakayama , K. , Shiosaka , T. , Yamamoto , H. and Honda , K. 2002 . Bisphenol A in combination with insulin can accelerate the conversion of 3T3-L1 fibroblasts to adipocytes . J. Lipid Res. , 43 : 676 – 684 .
   PubMed Web of Science ®Google Scholar
• Mattes , W. B. , Pettit , S. D. , Sansone , S. A. , Bushel , P. R. and Waters , M. D. 2004 . Database development in toxicogenomics: Issues and efforts . Environ. Health Perspect. , 112 : 495 – 505 .
   PubMed Web of Science ®Google Scholar
• Matthiessen , P. and Johnson , I. 2007 . Implications of research on endocrine disruption for the environmental risk assessment, regulation and monitoring of chemicals in the European Union . Environ. Pollut. , 146 : 9 – 18 .
   PubMed Web of Science ®Google Scholar
• Mayer , G. and Jenne , A. 2004 . Aptamers in research and drug development . Biodrugs , 18 : 351 – 359 .
   PubMed Web of Science ®Google Scholar
• McAllister , B. G. and Kime , D. E. 2003 . Early life exposure to environmental levels of the aromatase inhibitor tributyltin causes masculinisation and irreversible sperm damage in zebrafish (Danio rerio) . Aquat. Toxicol. , 65 : 309 – 316 .
   PubMed Web of Science ®Google Scholar
• McCauley , L. A. , Anger , W. K. , Keifer , M. , Langley , R. , Robson , M. G. and Rohlman , D. 2006 . Studying health outcomes in farmworker populations exposed to pesticides . Environ. Health Perspect. , 114 : 953 – 960 .
   PubMed Web of Science ®Google Scholar
• McKinney , J. D. and Waller , C. L. 1998 . Molecular determinants of hormone mimicry: halogenated aromatic hydrocarbon environmental agents . J. Toxicol. Environ. Health B , 1 : 27 – 58 .
   PubMed Web of Science ®Google Scholar
• Merrick , B. A. and Bruno , M. E. 2004 . Genomic and proteomic profiling for biomarkers and signature profiles of toxicity . Curr. Opin. Mol. Ther. , 6 : 600 – 607 .
   PubMed Web of Science ®Google Scholar
• Moggs , J. G. , Tinwell , H. , Spurway , T. , Chang , H. S. , Pate , I. , Lim , F. L. , Moore , D. J. , Soames , A. , Stuckey , R. , Currie , R. , Zhu , T. , Kimber , I. , Ashby , J. and Orphanides , G. 2004 . Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth . Environ. Health Perspect. , 112 : 1589 – 1606 .
   PubMed Web of Science ®Google Scholar
• Mokdad , A. H. , Ford , E. S. , Bowman , B. A. , Dietz , W.H. , Vinicor , F. , Bales , V. S. and Marks , J. S. 2003 . Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001 . J. Am. Med. Assoc. , 289 : 76 – 79 .
   PubMed Web of Science ®Google Scholar
• Morgan , H. D. , Santos , F. , Green , K. , Dean , W. and Reik , W. 2005 . Epigenetic reprogramming in mammals . Hum. Mol. Genet. , 14 : R47 – R58 .
   PubMed Web of Science ®Google Scholar
• Morishima , A. , Grumbach , M. M. , Simpson , E. R. , Fisher , C. and Qin , K. 1995 . Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens . J. Clin. Endocrinol. Metab. , 80 : 3689 – 3698 .
   PubMed Web of Science ®Google Scholar
• Moriyama , K. , Tagami , T. , Akamizu , T. , Usui , T. , Saijo , M. , Kanamoto , N. , Hataya , Y. , Shimatsu , A. , Kuzuya , H. and Nakao , K. 2002 . Thyroid hormone action is disrupted by bisphenol A as an antagonist . J. Clin. Endocrinol. Metab. , 87 : 5185 – 5190 .
   PubMed Web of Science ®Google Scholar
• Morley , R. 2006 . Fetal origins of adult disease . Semin. Fetal Neonatal Med. , 11 : 73 – 78 .
   PubMed Web of Science ®Google Scholar
• Mu , Y. M. , Yanase , T. , Nishi , Y. , Takayanagi , R. , Goto , K. and Nawata , H. 2001 . Combined treatment with specific ligands for PPARgamma:RXR nuclear receptor system markedly inhibits the expression of cytochrome P450arom in human granulosa cancer cells . Mol. Cell. Endocrinol. , 181 : 239 – 248 .
   PubMed Web of Science ®Google Scholar
• Mu , Y. M. , Yanase , T. , Nishi , Y. , Waseda , N. , Oda , T. , Tanaka , A. , Takayanagi , R. and Nawata , H. 2000 . Insulin sensitizer, troglitazone, directly inhibits aromatase activity in human ovarian granulosa cells . Biochem. Biophys. Res. Comm. , 271 : 710 – 713 .
   PubMed Web of Science ®Google Scholar
• Muhle , R. , Trentacoste , S. V. and Rapin , I. 2004 . The genetics of autism . Pediatrics , 113 : e472 – e486 .
   PubMed Web of Science ®Google Scholar
• Muller , L. and Kasper , P. 2000 . Human biological relevance and the use of threshold-arguments in regulatory genotoxicity assessment: Experience with pharmaceuticals . Mutat. Res. , 464 : 19 – 34 .
   PubMed Web of Science ®Google Scholar
• Mumby , M. and Brekken , D. 2005 . Phosphoproteomics: New insights into cellular signaling . Genome Biol. , 6 : 230
   PubMed Web of Science ®Google Scholar
• Murata , Y. , Robertson , K. M. , Jones , M. E. and Simpson , E. R. 2002 . Effect of estrogen deficiency in the male: The ArKO mouse model . Mol. Cell. Endocrinol. , 193 : 7 – 12 .
   PubMed Web of Science ®Google Scholar
• Mylchreest , E. , Wallace , D. G. , Cattley , R. C. and Foster , P. M. 2000 . Dose dependent alterations in androgen-regulated male reproductive development in rats exposed to di(n-butyl) phthalate during late gestation . Toxicol. Sci. , 55 : 143 – 151 .
   PubMed Web of Science ®Google Scholar
• Naaz , A. , Yellayi , S. , Zakroczymski , M. A. , Bunickm , D. , Doerge , D. R. , Lubahn , D. B. , Helferich , W. G. and Cooke , P. S. 2003 . The soy isoflavone genistein decreases adipose deposition in mice . Endocrinology , 144 : 3315 – 3320 .
   PubMed Web of Science ®Google Scholar
• Naaz , A. , Zakroczymski , M. , Heine , P. , Taylor , J. , Saunders , P. , Lubahn , D. and Cooke , P. S. 2002 . Effect of ovariectomy on adipose tissue of mice in the absence of estrogen receptor a (ERa): A potential role for estrogen receptor b (ERb) . Horm. Metab. Res. , 34 : 758 – 763 .
   PubMed Web of Science ®Google Scholar
• Naciff , J. M. and Daston , G. P. 2004 . Toxicogenomic approach to endocrine disrupters: Identification of a transcript profile characteristic of chemicals with estrogenic activity . Toxicol. Pathol. , 32 : 59 – 70 .
   PubMedGoogle Scholar
• Naciff , J. M. , Overmann , G. J. , Torontali , S. M. , Carr , G. J. , Tiesman , J. P. and Daston , G. P. 2004 . Impact of the phytoestrogen content of laboratory animal feed on the gene expression profile of the reproductive system in the immature female rat . Environ. Health Perspect. , 112 : 1519 – 1526 .
   PubMed Web of Science ®Google Scholar
• Nadal , A. , Ropero , A. B. , Laribi , O. , Maillet , M. , Fuentes , E. and Soria , B. 2000 . Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor alpha and estrogen receptor beta . Proc. Natl. Acad. Sci. USA , 97 : 11603 – 11608 .
   PubMed Web of Science ®Google Scholar
• National Institute of Environmental Health Sciences. 2003. TRC—Toxicogenomics Research Consortium. http://www.niehs.nih.gov/dert/trc/glossary.htm
   Google Scholar
• National Research Council. 1999. Exposures: Sources and dynamics of hormonally active agents in the environment. In Hormonally active agents in the environment. National Academy Press. www.nap.edu/openbook/0309064198/html
   Google Scholar
• Newbold , R. R. , Hanson , R. B. , Jefferson , W. N. , Bullock , B. C. , Haseman , J. and McLachlan , J. A. 1998 . Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol . Carcinogenesis , 19 : 1655 – 1663 .
   PubMed Web of Science ®Google Scholar
• Newton , R. K. , Aardema , M. and Aubrecht , J. 2004 . The utility of DNA microarrays for characterizing genotoxicity . Environ. Health Perspect. , 112 : 420 – 422 .
   PubMed Web of Science ®Google Scholar
• Nuwaysir , E. F. , Bittner , M. , Trent , J. , Barrett , J. C. and Afshari , C. A. 1999 . Microarrays and toxicology: the advent of toxicogenomics . Mol. Carcinogen. , 24 : 153 – 159 .
   PubMed Web of Science ®Google Scholar
• Oberemm , A. , Onyon , L. and Gundert-Remy , U. 2005 . How can toxicogenomics inform risk assessment? . Toxicol. Appl. Pharmacol. , 207 : 592 – 598 .
   PubMedGoogle Scholar
• Ohtake , F. , Takeyama , K. L. , Matsumoto , T. , Kitagawa , H. , Yamamoto , Y. , Nohara , K. , Tohyama , C. , Krust , A. , Mimura , J. , Chambon , P. , Yanagisawa , J. , Fujii-Kuriyama , Y. and Kato , S. 2003 . Modulation of oestrogen receptor signaling by association with the activated dioxin receptor . Nature , 423 : 545 – 550 .
   PubMed Web of Science ®Google Scholar
• Okano , M. , Bell , D. W. , Haber , D. A. and Li , E. 1999 . DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development . Cell , 99 : 247 – 257 .
   PubMed Web of Science ®Google Scholar
• Okuno , S. , Akazawa , S. , Yasuhi , I. , Kawasaki , E. , Matsumoto , K. , Yamasaki , H. , Matsuo , H. , Yamaguchi , Y. and Nagataki , S. 1995 . Decreased expression of the GLUT4 glucose transporter protein in adipose tissue during pregnancy . Horm. Metab. Res. , 27 : 231 – 234 .
   PubMed Web of Science ®Google Scholar
• Olden , K. , Call , N. , Sobral , B. and Oakes , R. 2004 . Toxicogenomics through the eyes of informatics: Conference Overview and Recommendations . Environ. Health Perspect. , 112 : 805 – 807 .
   PubMedGoogle Scholar
• Osius , N. , Karmaus , W. , Kruse , H. and Witten , J. 1999 . Exposure to polychlorinated biphenyls and levels of thyroid hormones in children . Environ. Health Perspect. , 107 : 843 – 849 .
   PubMed Web of Science ®Google Scholar
• Ott , M.G. , Zober , A. , Messerer , P. and German , C. 1994 . Laboratory results for selected target organs in 138 individuals occupationally exposed to TCDD . Chemosphere , 29 : 9 – 11 .
   Web of Science ®Google Scholar
• Pappas , T. C. , Gametchu , B. and Watson , C.S. 1995 . Membrane estrogen receptors identified by multiple antibody labeling and impeded–ligand binding . FASEB J. , 9 : 404 – 410 .
   PubMed Web of Science ®Google Scholar
• Parks , L. G. , Ostby , J. S. , Lambright , C. R. , Abbott , B. D. , Klinefelter , G. R. , Barlow , N. J. and Gray , L. E. 2000 . The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat . Toxicol. Sci. , 58 : 339 – 349 .
   PubMed Web of Science ®Google Scholar
• Patandin , S. , Lanting , C. I. , Mulder , P. G. , Boersma , E. R. , Sauer , P. J. and Weisglas-Kuperus , N. 1999 . Effects of environmental exposure to polychlorinated biphenyls and dioxins on cognitive abilities in Dutch children at 42 months of age . J. Pediatr. , 134 : 33 – 41 .
   PubMed Web of Science ®Google Scholar
• Paules , R. 2003 . Phenotypic anchoring: linking cause and effect . Environ. Health Perspect. , 111 : A338 – A339 .
   PubMed Web of Science ®Google Scholar
• Pennie , W. , Pettit , S. D. and Lord , P. G. 2004 . Toxicogenomics in risk assessment: An overview of an HESI Collaborative Research Program . Environ. Health Perspect. , 112 : 417 – 419 .
   PubMed Web of Science ®Google Scholar
• Pesatori , A. C. , Consonni , D. , Bachetti , S. , Zocchetti , C. , Bonzini , M. , Baccarelli , A. and Bertazzi , P. A. 2003 . Short- and long-term morbidity and mortality in the population exposed to dioxin after the ‘Seveso Accident.’ . Ind. Health , 41 : 127 – 138 .
   PubMed Web of Science ®Google Scholar
• Peterson , R. E. , Theobald , H. M. and Kimmel , G. L. 1993 . Developmental and reproductive toxicity of dioxins and related compounds: Cross-species comparisons . Crit. Rev. Toxicol. , 23 : 283 – 335 .
   PubMed Web of Science ®Google Scholar
• Pettit , S. D. 2004 . Toxicogenomics in risk assessment: Communicating the challenges . Environ. Health Perspect. , 112 : A662
   Web of Science ®Google Scholar
• Pfister , S. , Schlaeger , C. , Mendrzyk , F. , Wittmann , A. , Benner , A. , Kulozik , A. , Scheurlen , W. , Radlwimmer , B. and Lichter , P. 2007 . Array-based profiling of reference-independent methylation status (aPRIMES) identifies frequent promoter methylation and consecutive downregulation of ZIC2 in pediatric medulloblastoma . Nucleic Acids Res. , 35 : e51
   Web of Science ®Google Scholar
• Phillip , M. , De Boer , C. , Pilpel , D. , Karplus , M. and Sofer , S. 1996 . Clitoral and penile sizes of full term newborns in two different ethnic groups . J. Pediatr. Endocrinol. Metab. , 9 : 175 – 179 .
   PubMed Web of Science ®Google Scholar
• Phillips , K. P. , Foster , W. G. , Leiss , W. L. , Sahni , V. , Karyakina , N. , Turner , M. C. , Kacew , S. and Krewski , D. 2008 . Assessing and managing risks arising from exposure to endocrine active chemicals . J. Toxicol. Environ. Health B , this issue.
   Web of Science ®Google Scholar
• Pitteloud , N. , Mootha , V. K. , Dwyer , A. A. , Hardin , M. , Lee , H. , Eriksson , K. F. , Tripathy , D. , Yialamas , M. , Groop , L. , Elahi , D. and Hayes , F. J. 2005 . Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men . Diabetes Care , 28 : 1636 – 1642 .
   PubMed Web of Science ®Google Scholar
• Prins , J. B. 2002 . Adipose tissue as an endocrine organ . Best Pract. Res. Clin. Endocrinol. Metab. , 16 : 639 – 651 .
   PubMed Web of Science ®Google Scholar
• Pryor , J. L. , Hughes , C. , Foster , W. , Hales , B. F. and Robaire , B. 2000 . Critical windows of exposure for children's health: The reproductive system in animals and humans . Environ. Health Perspect. , 108 : 491 – 503 .
   PubMed Web of Science ®Google Scholar
• Rangwala , S. M. and Lazar , M. A. 2004 . Peroxisome proliferator-activated receptor γ in diabetes and metabolism . Trends Pharmacol. Sci. , 25 : 331 – 336 .
   PubMed Web of Science ®Google Scholar
• Reynolds , V. L. 2005 . Applications of emerging technologies in toxicology and safety assessment . Int. J. Toxicol. , 24 : 135 – 137 .
   PubMed Web of Science ®Google Scholar
• Rhees , R. W. , Kirk , B. A. , Sephton , S. and Lephart , E. D. 1997 . Effects of prenatal testosterone on sexual behavior, reproductive morphology and LH secretion in the female rat . Dev. Neurosci. , 19 : 430 – 437 .
   PubMed Web of Science ®Google Scholar
• Robinson , D. E. , Pettit , S. D. and Morgan , D. G. 2003 . “ Use of genomics in mechanism based risk assessment ” . In Toxicogenomics , Edited by: Inoue , T. and Pennie , W. D. 194 – 203 . Tokyo : Springer-Verlag .
   Google Scholar
• Robinson-Rechavi , M. , Escriva Garcia , H. and Laudet , V. 2003 . The nuclear receptor superfamily . J. Cell Sci. , 116 : 585 – 586 .
   PubMed Web of Science ®Google Scholar
• Roemer , I. , Reik , W. , Dean , W. and Klose , J. 1997 . Epigenetic inheritance in the mouse . Curr. Biol. , 7 : 277 – 280 .
   PubMed Web of Science ®Google Scholar
• Romano-Riquer , S. P. , Hernandez-Avila , M. , Gladen , B. C. , Cupul-Uicab , L. A. and Longnecker , M. P. 2007 . Reliability and determinants of anogenital distance and penis dimensions in male newborns from Chiapas, Mexico . Paediatr. Perinat. Epidemiol. , 21 : 219 – 228 .
   PubMed Web of Science ®Google Scholar
• Ropero , A. B. , Alonso-Magdalena , P. , Ripoll , C. , Fuentes , E. and Nadal , A. 2006 . Rapid endocrine disruption: Environmental estrogen actions triggered outside the nucleus . J. Steroid Biochem. Mol Biol. , 102 : 163 – 169 .
   PubMed Web of Science ®Google Scholar
• Rosenbaum , D. , Haber , R. S. and Dunaif , A. 1993 . Insulin resistance in polycystic ovary syndrome: Decreased expression of GLUT-4 glucose transporters in adipocytes . Am. J. Physiol. , 264 : E197 – E202 .
   PubMed Web of Science ®Google Scholar
• Roy , D. , Palangat , M. , Chen , C.-W. , Thomas , R. D. , Colerangle , J. , Atkinson , A. and Yan , Z.-J. 1997 . Biochemical and molecular changes at the cellular level in response to exposure to environmental estrogen-like chemicals . J. Toxicol. Environ. Health , 50 : 1 – 29 .
   PubMed Web of Science ®Google Scholar
• Ruan , H. , Hacohen , N. , Golub , T. R. , Van Parijs , L. and Lodish , H. F. 2002 . Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: Nuclear factor-kappaB activation by TNF-alpha is obligatory . Diabetes , 51 : 1319 – 1336 .
   PubMed Web of Science ®Google Scholar
• Safe , S. and Krishnan , V. 1995 . Cellular and molecular biology of aryl hydrocarbon (Ah) receptor-mediated gene expression . Arch. Toxicol. Suppl. , 17 : 99 – 115 .
   PubMedGoogle Scholar
• Saitoh , M. , Yanase , T. , Morinaga , H. , Tanabe , M. , Mu , Y. M. , Nishi , Y. , Nomura , M. , Okabe , T. , Goto , K. , Takayanagi , R. and Nawata , H. 2001 . Tributyltin or triphenyltin inhibits aromatase activity in the human granulosa-like tumor cell line KGN . Biochem. Biophys. Res. Comm. , 289 : 198 – 204 .
   PubMed Web of Science ®Google Scholar
• Sakurai , K. , Kawazuma , M. , Adachi , T. , Harigaya , T. , Saito , Y. , Hashimoto , N. and Mori , C. 2004 . Bisphenol A affects glucose transport in mouse 3T3-F442A adipocytes . Br. J. Pharmacol. , 141 : 209 – 214 .
   PubMed Web of Science ®Google Scholar
• Salazar-Martinez , E. , Romano-Riquer , P. , Yanez-Marquez , E. , Longnecker , M. P. and Hernandez-Avila , M. 2004 . Anogenital distance in human male and female newborns: A descriptive, cross-sectional study . Environ. Health , 3 : 8
   PubMedGoogle Scholar
• Schena , M. , Heller , R. A. , Konrad , K. , Lachenmeier , E. and Davis , R. W. 1998 . Microarrays: Biotechnology's discovery platform for functional genomics . Trends Biotech. , 16 : 301 – 306 .
   PubMed Web of Science ®Google Scholar
• Schena , M. , Shalon , D. , Davis , R. W. and Brown , P. O. 1995 . Quantitative monitoring of gene expression patterns with a complementary DNA microarray . Science , 270 : 467 – 470 .
   PubMed Web of Science ®Google Scholar
• Schmidt , C. W. 2003 . Toxicogenomics . Environ. Health Perspect. , 111 : A20 – A25 .
   Web of Science ®Google Scholar
• Schumacher , A. , Kapranov , P. , Kaminsky , Z. , Flanagan , J. , Assadzadeh , A. , Yau , P. , Virtanen , C. , Winegarden , N. , Cheng , J. , Gingeras , T. and Petronis , A. 2006 . Microarray-based DNA methylation profiling: Technology and applications . Nucleic Acids Res. , 34 : 528 – 542 .
   PubMed Web of Science ®Google Scholar
• Shaul , P. W. 2002 . Regulation of endothelial nitric oxide synthase: Location, location, location . Ann. Rev. Physiol. , 64 : 749 – 774 .
   PubMed Web of Science ®Google Scholar
• Shepherd , G. M. 2002 . Supporting databases for neuroscience research . J. Neurosci. , 22 : 1497
   PubMed Web of Science ®Google Scholar
• Shepherd , G. M. , Mirsky , J. S. , Healy , M. D. , Singer , M. S. , Skoufos , E. , Hines , M. S. , Nadkarni , P. M. and Miller , P. L. 1998 . The Human Brain Project: Neuroinformatics tools for integrating, searching and modeling multidisciplinary neuroscience data . Trends Neurosci. , 21 : 460 – 468 .
   PubMed Web of Science ®Google Scholar
• Shi , H. , Wei , S. H. , Leu , Y. W. , Rahmatpanah , F. , Liu , J. C. , Yan , P. S. , Nephew , K. P. and Huang , T. H. 2003 . Triple analysis of the cancer epigenome: An integrated microarray system for assessing gene expression, DNA methylation, and histone acetylation . Cancer Res. , 63 : 2164 – 2171 .
   PubMed Web of Science ®Google Scholar
• Shin , J.-H. , Kim , H. S. , Moon , H. J. , Kang , I. H. , Kim , T. S. , Seok , J. H. , Kim , I. Y. , Park , K. L. , Han , S. Y. and Nam , S. Y. 2002 . Effects of flutamide on punerty in male rats: An evaluation of the protocol for the assessment of pubertal development and thyroid function . J. Toxicol. Environ. Health A , 65 : 433 – 445 .
   PubMed Web of Science ®Google Scholar
• Shirai , T. and Asamoto , M. 2003 . Application of toxicogenomics to the endocrine disrupter issue . Pure Appl. Chem. , 75 : 2419 – 2422 .
   Web of Science ®Google Scholar
• Sinha , A. , Singh , C. , Parmar , D. and Singh , M. P. 2007 . Proteomics in clinical interventions: achievements and limitations in biomarker development . Life Sci. , 80 : 1345 – 1354 .
   PubMed Web of Science ®Google Scholar
• Skakkebaek , N. E. , Rajpert-De Meyts , E. and Main , K. M. 2001 . Testicular dysgenesis syndrome: An increasingly common developmental disorder with environmental aspects . Hum. Reprod. , 16 : 972 – 978 .
   PubMed Web of Science ®Google Scholar
• Smith , E. P. , Boyd , J. , Frank , G. R. , Takahashi , H. , Cohen , R. M. , Specker , B. , Williams , T. C. , Lubahn , D. B. and Korach , K. S. 1994 . Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man . N. Engl. J. Med. , 331 : 1056 – 1061 .
   PubMed Web of Science ®Google Scholar
• Smith , L. and Greenfield , A. 2003 . DNA microarrays and development . Hum. Mol. Genet. , 12 : R1 – R8 .
   PubMed Web of Science ®Google Scholar
• Solomon , C. G. , Hu , F. B. , Dunaif , A. , Rich-Edwards , J. , Willett , W. C. , Hunter , D. J. , Colditz , G. A. , Speizer , F. E. and Manson , J. E. 2001 . Long or highly irregular menstrual cycles as a marker for risk of type 2 diabetes mellitus . J. Am. Med. Assoc. , 286 : 2421 – 2426 .
   PubMed Web of Science ®Google Scholar
• Steiner , G. , Suter , L. , Boess , F. , Gasser , R. , de Vera , M.C. , Albertini , S. and Ruepp , S. 2004 . Discriminating different classes of toxicants by transcript profiling . Environ. Health Perspect. , 112 : 1236 – 1248 .
   PubMed Web of Science ®Google Scholar
• Steiner , S. and Anderson , N. L. 2000 . Expression profiling in toxicology: Potential and limitations . Toxicol. Lett. , 112–113 : 467 – 471 .
   PubMed Web of Science ®Google Scholar
• Steinhardt , G. F. 2004 . Endocrine disruption and hypospadias . Adv. Exp. Med. Biol. , 545 : 203 – 215 .
   PubMed Web of Science ®Google Scholar
• Stults , J. T. and Arnott , D. 2005 . Proteomics . Methods Enzymol. , 402 : 245 – 289 .
   PubMed Web of Science ®Google Scholar
• Sugaya , A. , Sugiyama , T. , Yanase , S. , Shen , X. X. , Minoura , H. and Toyoda , N. 2000 . Expression of glucose transporter 4 mRNA in adipose tissue and skeletal muscle of ovariectomized rats treated with sex steroid hormones . Life Sci. , 66 : 641 – 648 .
   PubMed Web of Science ®Google Scholar
• Swan , S. H. , Main , K. M. , Liu , F. , Stewart , S. L. , Kruse , R. L. , Calafat , A. M. , Mao , C. S. , Redmon , J. B. , Ternand , C. L. , Sullivan , S. , Teague , J. L. and the Study for Future Families Research Team . 2005 . Decrease in anogenital distance among male infants with prenatal phthalate exposure . Environ. Health Perspect. , 113 : 1056 – 1061 .
   PubMed Web of Science ®Google Scholar
• Tabb , M. M. and Blumberg , B. 2006 . New modes of action for endocrine-disrupting chemicals . Mol. Endocrinol. , 20 : 475 – 482 .
   PubMed Web of Science ®Google Scholar
• Takeda , K. , Toda , K. , Saibara , T. , Nakagawa , M. , Saika , K. , Onishi , T. , Sugiura , T. and Shizuta , Y. 2003 . Progressive development of insulin resistance phenotype in male mice with complete aromatase (CYP19) deficiency . J. Endocrinol. , 176 : 237 – 246 .
   PubMed Web of Science ®Google Scholar
• Taylor , K. H. , Pena-Hernandez , K. E. , Davis , J. W. , Arthur , G. L. , Duff , D. J. , Shi , H. , Rahmatpanah , F. B. , Sjahputera , O. and Caldwell , C. W. 2007 . Large-scale CpG methylation analysis identifies novel candidate genes and reveals methylation hotspots in acute lymphoblastic leukemia . Cancer Res. , 67 : 2617 – 2625 .
   PubMed Web of Science ®Google Scholar
• Thomas , J. G. , Olson , J. M. , Tapscott , S. J. and Zhao , L. P. 2001 . An efficient and robust statistical modeling approach to discover differentially expressed genes using genomic expression profiles . Genome Res. , 11 : 1227 – 1136 .
   PubMed Web of Science ®Google Scholar
• Thomas , P. , Pang , Y. , Filardo , E. J. and Dong , J. 2005 . Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells . Endocrinology , 146 : 624 – 632 .
   PubMed Web of Science ®Google Scholar
• Thybaud , V. , Le Fevre , A. C. and Boitier , E. 2007 . Application of toxicogenomics to genetic toxicology risk assessment . Environ. Mol. Mutagen. , 48 : 369 – 379 .
   PubMed Web of Science ®Google Scholar
• Tong , W. , Xie , Q. , Hong , H. , Shi , L. , Fang , H. and Perkins , R. 2004 . Assessment of prediction confidence and domain extrapolation of two structure–activity relationship models for predicting estrogen receptor binding activity . Environ. Health Perspect. , 112 : 1249 – 1254 .
   PubMed Web of Science ®Google Scholar
• Toraason , M. , Albertini , R. , Bayard , S. , Bigbee , W. , Blair , A. , Boffetta , P. , Bonassi , S. , Chanock , S. , Christiani , D. , Eastmond , D. , Hanash , S. , Henry , C. , Kadlubar , F. , Mirer , F. , Nebert , D. , Rapport , S. , Rest , K. , Rothman , N. , Ruder , A. , Savage , R. , Schulte , P. , Siemiatycki , J. , Shields , P. , Smith , M. , Tolbert , P. , Vermeulen , R. , Vineis , P. , Wacholder , S. , Ward , E. , Waters , M. and Weston , A. 2004 . Applying new biotechnologies to the study of occupational cancer—A workshop summary . Environ. Health Perspect. , 112 : 413 – 416 .
   PubMed Web of Science ®Google Scholar
• Toyoshiba , H. , Yamanaka , T. , Sone , H. , Parham , F. M. , Walker , N. J. , Martinez , J. and Portier , C.J. 2004 . Gene interaction network suggests dioxin induces a significant linkage between aryl hydrocarbon receptor and retinoic acid receptor beta . Environ. Health Perspect. , 112 : 1217 – 1224 .
   PubMed Web of Science ®Google Scholar
• Tsai , M. J. and O'Malley , B. W. 1994 . Molecular mechanisms of action of steroid/thyroid receptor superfamily members . Annu. Rev. Biochem. , 63 : 451 – 486 .
   PubMed Web of Science ®Google Scholar
• Turusov , V. S. , Trukhanova , L. S. , Parfenov , Y. D. and Tomatis , L. 1992 . Occurrence of tumours in the descendants of CBA male mice prenatally treated with diethylstilbestrol . Int. J. Cancer , 50 : 131 – 135 .
   PubMed Web of Science ®Google Scholar
• Tyshenko , M. G. and Leiss , W. 2005 . Current trends in publicly available genetic databases . Health Informatics J. , 11 : 295 – 308 .
   Google Scholar
• U.S. Environmental Protection Agency . Special report on environmental endocrine disruption: An effects assessment and analysis . EPA/630/R-96/012 . 1997 . Washington, DC: Office of Research and Development.
   Google Scholar
• Van Loveren , H. , Vos , J. , Putman , E. and Piersma , A. 2003 . Immunotoxicological consequences of perinatal chemical exposures: A plea for inclusion of immune parameters in reproduction studies . Toxicology , 185 : 185 – 191 .
   PubMed Web of Science ®Google Scholar
• van Steensel , B. and Henikoff , S. 2003 . Epigenomic profiling using microarrays . Biotechniques , 35 : 346 – 357 .
   PubMed Web of Science ®Google Scholar
• Vapnik , V. and Chapelle , O. 2000 . Bounds on error expectation for support vector machines . Neural. Comput. , 12 : 2013 – 2036 .
   PubMed Web of Science ®Google Scholar
• Varnum , S. M. , Covington , C.C. , Woodbury , R.L. , Petritis , K. , Kangas , L. J. , Abdullah , M. S. , Pounds , J. G. , Smith , R. D. and Zangar , R. C. 2003 . Proteomic characterization of nipple aspirate fluid: Identification of potential biomarkers of breast cancer . Breast Cancer Res. Treat. , 80 : 87 – 97 .
   PubMed Web of Science ®Google Scholar
• Vena , J. , Boffetta , P. , Becher , H. , Benn , T. , Bueno-de-Mesquita , H. B. , Coggon , D. , Colin , D. , Flesch-Janys , D. , Green , L. , Kauppinen , T. , Littorin , M. , Lynge , E. , Mathews , J. D. , Neuberger , M. , Pearce , N. , Pesatori , A.C. , Saracci , R. , Steenland , K. and Kogevinas , M. 1998 . Exposure to dioxin and nonneoplastic mortality in the expanded IARC international cohort study of phenoxy herbicide and chlorophenol production workers and sprayers . Environ. Health Perspect. , 106 : 645 – 653 .
   PubMed Web of Science ®Google Scholar
• Viant , M. R. , Rosenblum , E. S. and Tjeerdema , R. S. 2003 . NMR-based metabolomics: A powerful approach for characterizing the effects of environmental stressors on organism health . Environ. Sci. Technol. , 37 : 4982 – 4989 .
   PubMed Web of Science ®Google Scholar
• vom Saal , F. S. and Hughes , C. 2005 . An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment . Environ. Health Perspect. , 113 : 926 – 933 .
   PubMed Web of Science ®Google Scholar
• Walker , B. E. and Kurth , L. A. 1995 . Increased reproductive tract tumors in the female offspring of mice fed a high fat diet during the fetal stage of pregnancy . Cancer Lett. , 97 : 57 – 60 .
   PubMed Web of Science ®Google Scholar
• Walker , B. E. and Haven , M. I. 1997 . Intensity of multigenerational carcinogenesis from diethylstilbestrol in mice . Carcinogenesis , 18 : 791 – 793 .
   PubMed Web of Science ®Google Scholar
• Waring , J. F. , Ciurlionis , R. , Jolly , R. A. , Heindel , M. and Ulrich , R. G. 2001 . Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity . Toxicol. Lett. , 120 : 359 – 368 .
   PubMed Web of Science ®Google Scholar
• Watanabe , H. , Suzuki , A. , Goto , M. , Lubahn , D. B. , Handa , H. and Iguchi , T. 2004a . Tissue-specific estrogenic and non-estrogenic effects of a xenoestrogen, nonylphenol . J. Mol. Endocrinol. , 33 : 243 – 252 .
   PubMed Web of Science ®Google Scholar
• Watanabe , H. , Suzuki , A. , Goto , M. , Ohsako , S. , Tohyama , C. , Handa , H. and Iguchi , T. 2004b . Comparative uterine gene expression analysis after dioxin and estradiol administration . J. Mol. Endocrinol. , 33 : 763 – 771 .
   PubMed Web of Science ®Google Scholar
• Watanabe , H. , Suzuki , A. , Kobayashi , M. , Lubahn , D. , Handa , H. and Iguchi , T. 2003a . Analysis of temporal changes in the expression of estrogen regulated genes in the uterus . J. Mol. Endocrinol. , 30 : 347 – 358 .
   PubMed Web of Science ®Google Scholar
• Watanabe , H. , Suzuki , A. , Kobayashi , M. , Lubahn , D.B. , Handa , H. and Iguchi , T. 2003b . Similarities and differences in uterine gene expression patterns caused by treatment with physiological and non-physiological estrogen . J. Mol. Endocrinol. , 31 : 487 – 497 .
   PubMed Web of Science ®Google Scholar
• Watanabe , H. , Suzuki , A. , Mizutani , T. , Handa , H. and Iguchi , T. 2002a . “ Large-scale gene expression analysis for evaluation of endocrine disruptors ” . In Toxicogenomics , Edited by: Inoue , T. and Pennie , W. D. 149 – 155 . New York : Springer-Verlag .
   Google Scholar
• Watanabe , H. , Suzuki , A. , Mizutani , T. , Kohno , S. , Lubahn , D. B. , Handa , H. and Iguchi , T. 2002b . Genome-wide analysis of changes in early gene expression induced by estrogen . Genes Cells , 7 : 497 – 507 .
   PubMed Web of Science ®Google Scholar
• Watson , C. S. and Gametchu , B. 1999 . Membrane-initiated steroid actions and the proteins that mediate them . Proc. Soc. Exp. Biol. Med. , 220 : 9 – 19 .
   PubMed Web of Science ®Google Scholar
• Watson , C. S. and Gametchu , B. 2003 . Proteins of multiple classes may participate in nongenomic steroid actions . Proc .Soc. Exp. Biol Med. , 228 : 1272 – 1281 .
   PubMed Web of Science ®Google Scholar
• Watson , C. S. , Pappas , T. C. and Gametchu , B. 1995 . The other estrogen receptor in the plasma membrane: Implications for the actions of environmental estrogens . Environ. Health Perspect. , 103 : 41 – 50 .
   PubMed Web of Science ®Google Scholar
• Watson , C. S. , Bulayeva , N. N. , Wozniak , A. L. and Alyea , R. A. 2007 . Xenoestrogens are potent activators of nongenomic estrogenic responses . Steroids , 72 : 124 – 134 .
   PubMed Web of Science ®Google Scholar
• Wigle , D. T. 2003 . Child health and the environment , New York : Oxford University Press .
   Google Scholar
• Wild , S. , Roglic , G. , Green , A. , Sicree , R. and King , H. 2004 . Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030 . Diabetes Care , 27 : 1047 – 1053 .
   PubMed Web of Science ®Google Scholar
• Winneke , G. , Bucholski , A. , Heinzow , B. , Krämer , U. , Schmidt , E. , Walkowiak , J. , Wiener , J. A. and Steingrüber , H. J. 1998 . Developmental neurotoxicity of polychlorinated biphenyls (PCBS): Cognitive and psychomotor functions in 7-month old children . Toxicol Lett. , 102–103 : 423 – 428 .
   PubMed Web of Science ®Google Scholar
• Wishart , D. S. , Tzur , D. , Knox , C. , Eisner , R. , Guo , A. C. , Young , N. , Cheng , D. , Jewell , K. , Arndt , D. , Sawhney , S. , Fung , C. , Nikolai , L. , Lewis , M. , Coutouly , M. A. , Forsythe , I. , Tang , P. , Shrivastava , S. , Jeroncic , K. , Stothard , P. , Amegbey , G. , Block , D. , Hau , D. D. , Wagner , J. , Miniaci , J. , Clements , M. , Gebremedhin , M. , Guo , N. , Zhang , Y. , Duggan , G. E. , Macinnis , G. D. , Weljie , A. M. , Dowlatabadi , R. , Bamforth , F. , Clive , D. , Greiner , R. , Li , L. , Marrie , T. , Sykes , B. D. , Vogel , H. J. and Querengesser , L. 2007 . HMDB: The Human Metabolome Database . Nucleic Acids Res. , 35 ( Database issue ) : D521 – D526 .
   PubMed Web of Science ®Google Scholar
• Wong , C. , Kelce , W.R. , Sar , M. and Wilson , E. M. 1995 . Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide . J. Biol Chem. , 270 : 19998 – 20003 .
   PubMed Web of Science ®Google Scholar
• World Health Organization . 2002 . Global assessment of the state-of-the-science of endocrine disruptors , Edited by: Damstra , T. , Barlow , S. , Bergman , A. , Kavlock , R. and Van Der Kraak , G. Geneva : International Programme on Chemical Safety .
   Google Scholar
• Wu , O. , Ohsako , S. , Ishimura , R. , Suzuki , J. S. and Tohyama , C. 2004 . Exposure of mouse preimplantation embryos to 2,3,7,8-tertacholordibenzo-p-dioxin (TCDD) alters the methylation status of imprinted genes H19 and Igf2 . Biol. Reprod. , 70 : 1790 – 1797 .
   PubMed Web of Science ®Google Scholar
• Xiao , Z. , Prieto , D. , Conrads , T. P. , Veenstra , T. D. and Issaq , H. J. 2005 . Proteomic patterns: Their potential for disease diagnosis . Mol. Cell. Endocrinol. , 230 : 95 – 106 .
   PubMed Web of Science ®Google Scholar
• Yan , P. S. , Efferth , T. , Chen , H. L. , Lin , J. , Rodel , F. , Fuzesi , L. and Huang , T. H. 2002 . Use of CpG island microarrays to identify colorectal tumors with a high degree of concurrent methylation . Methods , 27 : 162 – 169 .
   PubMed Web of Science ®Google Scholar
• You , L. , Casanova , M. , Archibeque-Engle , A. , Sar , M. , Fan , L. Q. and Heck , H. A. 1998 . Impaired male sexual development in perinatal Sprague-Dawley and Long-Evans hooded rats exposed in utero and lactationally to p, p′-DDE . Toxicol. Sci. , 45 : 162 – 173 .
   PubMed Web of Science ®Google Scholar
• You , L. , Chan , S. K. , Bruce , J. M. , Archibeque-Engle , S. , Casanova , M. , Corton , J. C. and Heck , H.A. 1999 . Modulation of testosterone metabolizing hepatic cytochrome (p-450) enzymes in developing Sprague-Dawley rats following in utero exposure to p, p′-DDE . Toxicol. Sci. , 158 : 97 – 205 .
   Google Scholar
• Zober , A. , Ott , M. G. and Messerer , P. 1994 . Morbidity follow up study of BASF employees exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) after a 1953 chemical reactor incident . Occup. Environ. Med. , 51 : 479 – 486 .
   PubMed Web of Science ®Google Scholar
• Zoeller , R. T. 2003a . Thyroid toxicology and brain development: Should we think differently? . Environ. Health Perspect. , 111 : A628
   Web of Science ®Google Scholar
• Zoeller , R. T. 2003b . Challenges confronting risk analysis of potential thyroid toxicants . Risk Anal. , 23 : 143 – 162 .
   PubMed Web of Science ®Google Scholar
• Zoeller , R. T. 2005 . Environmental chemicals as thyroid hormone analogues: New studies indicate that thyroid hormone receptors are targets of industrial chemicals? . Mol. Cell. Endocrin. , 242 : 10 – 15 .
   PubMed Web of Science ®Google Scholar
• Zoeller , R. T. 2006 . Endocrine disruptors: Do family lines carry an epigenetic record of previous generations' exposures? . Endocrinology , 147 : 5513 – 5514 .
   PubMed Web of Science ®Google Scholar
• Zoeller , R. T. , Bansal , R. and Parris , C. 2005 . Bisphenol A, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine, and alters RC3/neurogranin expression in the developing rat brain . Endocrinology , 146 : 607 – 612 .
   PubMed Web of Science ®Google Scholar
• Zoeller , R. T. , Dowling , A. L. and Vas , A. A. 2000 . Developmental exposure to polychlorinated biphenyls exerts thyroid hormone-like effects on the expression of RC3/neurogranin and myelin basic protein messenger ribonucleic acids in the developing rat brain . Endocrinology , 141 : 181 – 189 .
   PubMed Web of Science ®Google Scholar