Evaluation of Epidemiology and Animal Data for Risk Assessment: Chlorpyrifos Developmental Neurobehavioral Outcomes

REFERENCES

• Abdel-Rahman , A. , Dechkovskaia , A. M. , Mehta-Simmons , H. , Guan , X. , Khan , W. and Abou-Donia , M. 2003 . Increased expression of glial fibrillary acidic protein in cerebellum and hippocampus: Differential effects on neonatal brain regional acetylcholinesterase following maternal exposure to combined chlorpyrifos and nicotine . J. Toxicol. Environ. Health A , 66 : 2047 – 66 .
   PubMed Web of Science ®Google Scholar
• Abdel-Rahman , A. , Dechkovskaia , A. M. , Mehta-Simmons , H. , Sutton , J. M. , Guan , X. , Khan , W. A. and Abou-Donia , M. B. 2004 . Maternal exposure to nicotine and chlorpyrifos, alone and in combination, leads to persistently elevated expression of glial fibrillary acidic protein in the cerebellum of the offspring in late puberty . Arch. Toxicol. , 78 : 467 – 76 .
   PubMed Web of Science ®Google Scholar
• Abou-Donia , M. B. , Khan , W. A. , Dechkovskaia , A. M. , Goldstein , L. B. , Bullman , S. L. and Abdel-Rahman , A. 2006 . In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats . Arch. Toxicol. , 80 : 620 – 31 .
   PubMed Web of Science ®Google Scholar
• Abu-Quare , A. W. , Abdel-Rahman , A. , Brownie , C. , Kishk , A. M. and Abou-Donia , M. B. 2001 . Inhibition of cholinesterase enzymes following a single dermal dose of chlorpyrifos and methyl parathion, alone and in combination in pregnant rats . J. Toxicol. Environ. Health A , 63 : 173 – 89 .
   PubMed Web of Science ®Google Scholar
• Achenbach , T. and Rescorla , L. 2000 . Manual for the ASEBA Preschool Forms and Profiles , Burlington , VT : University of Vermont, Research Center for Children, Youth, and Families .
   Google Scholar
• Adams , J. 2010 . Editor's note by editor-in-chief . Neurotoxicol. Teratol. , 32 : iii
   Google Scholar
• Aldridge , J. E. , Levin , E. D. , Seidler , F. J. and Slotkin , T. A. 2005a . Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression . Environ. Health Perspect. , 113 : 527 – 31 .
   PubMed Web of Science ®Google Scholar
• Aldridge , J. E. , Meyer , A. , Seidler , F. J. and Slotkin , T. A. 2005b . Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure . Environ. Health Perspect. , 113 : 1027 – 31 .
   PubMed Web of Science ®Google Scholar
• Aldridge , J. E. , Meyer , A. , Seidler , F. J. and Slotkin , T. A. 2005c . Developmental exposure to terbutaline and chlorpyrifos: Pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions . Toxicol. Appl. Pharmacol. , 203 : 132 – 44 .
   PubMed Web of Science ®Google Scholar
• Aldridge , J. E. , Seidler , F. J. , Meyer , A. , Thillai , I. and Slotkin , T. A. 2003 . Serotonergic systems targeted by developmental exposure to chlorpyrifos: Effects during different critical periods . Environ. Health Perspect. , 111 : 1736 – 43 .
   PubMed Web of Science ®Google Scholar
• Aldridge , J. E. , Seidler , F. J. and Slotkin , T. A. 2004 . Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling . Environ. Health Perspect. , 112 : 148 – 55 .
   PubMed Web of Science ®Google Scholar
• Alexander , B. H. , Burns , C. J. , Bartels , M. J. , Acquavella , J. F. , Mandel , J. S. , Gustin , C. and Baker , B. A. 2006 . Chlorpyrifos exposure in farm families: Results from the farm family exposure study . J. Expos. Sci. Environ. Epidemiol. , 16 : 447 – 56 .
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association . 2000 . Diagnostic and statistical manual of mental disorders , 4th ed., text rev , Washington , DC : American Psychiatric Association .
   Google Scholar
• Amira , M. , Hamadi , F. , Kamel , J. , Khansa , C. , Feriel , E. , Fadhel , G. and Nagiba , Z. 2005 . Impact of chlorpyrifos on cerebrum and cerebellum maturity in suckling rats . Toxicol. Environ Chem. , 87 : 551 – 58 .
   Google Scholar
• Ballough , G. P. H. , Kan , R. K. , Nicholson , J. D. , Fath , D.M. , Tompkins , C.P. , Moffa , G. M. and Filbert , M. G. 2008 . Modest neuroprotection by 2-aminoethyl diphenylborinate (2-APB), a transient receptor potential channel inhibitor and inositol 1,4,5-triphosphate receptor antagonist . J. Med. CBR Def. , 6 : 1 – 20 .
   Google Scholar
• Barr , D. B. and Angerer , J. 2006 . Potential uses of biomonitoring data: A case study using the organophosphorus pesticides chlorpyrifos and malathion . Environ. Health Perspect. , 114 : 1763 – 69 .
   PubMed Web of Science ®Google Scholar
• Betancourt , A. M. , Burgess , S. C. and Carr , R. L. 2006 . Effect of developmental exposure to chlorpyrifos on the expression of neurotrophin growth factors and cell-specific markers in neonatal rat brain . Toxicol. Sci. , 92 : 500 – 6 .
   PubMed Web of Science ®Google Scholar
• Betancourt , A. M. and Carr , R. L. 2004 . The effect of chlorpyrifos and chlorpyrifos-oxon on brain cholinesterase, muscarinic receptor binding, and neurotrophin levels in rats following early postnatal exposure . Toxicol. Sci. , 77 : 63 – 71 .
   PubMed Web of Science ®Google Scholar
• Betancourt , A. M. , Filipov , N. M. and Carr , R. L. 2007 . Alteration of neurotrophins in the hippocampus and cerebral cortex of young rats exposed to chlorpyrifos and methyl parathion . Toxicol. Sci. , 100 : 445 – 55 .
   PubMed Web of Science ®Google Scholar
• Billauer-Haimovitch , H. , Slotkin , T. A. , Dotan , S. , Langford , R. , Pinkas , A. and Yanai , J. 2009 . Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by nicotine administration and neural stem cell transplantation . Behav. Brain Res. , 205 : 499 – 504 .
   PubMed Web of Science ®Google Scholar
• Black , M. M. and Matula , K. 2000 . Essentials of Bayley Scales of Infant Development—II. Assessment , New York, NY : John Wiley and Sons .
   Google Scholar
• Braquenier , J. B. , Quertemont , E. , Tirelli , E. and Plumier , J. C. 2010 . Anxiety in adult female mice following perinatal exposure to chlorpyrifos . Neurotoxicol. Teratol. , 32 : 234 – 39 .
   PubMed Web of Science ®Google Scholar
• Bravo , R. , Caltabiano , L. M. , Weerasekera , G. , Whitehead , R. D. , Fernandez , C. , Needham , L. L. , Bradman , A. and Barr , D. B. 2004 . Measurement of dialkyl phosphate metabolites of organophosphorus pesticides in human urine using lyophilization with gas chromatography-tandem mass spectrometry and isotope dilution quantification . J. Expos. Anal. Environ. Epidemiol. , 14 : 249 – 59 .
   PubMedGoogle Scholar
• Brazelton , T. B. and Nugent , J. K. 1995 . Neonatal behavioral assessment scale , 3rd , London : Mac Keith Press .
   Google Scholar
• Brimijoin , S. and Koenigsberger , C. 1999 . Cholinesterases in neural development: New findings and toxicologic implications . Environ. Health Perspect. , 107 ( suppl. 1 ) : 59 – 64 .
   PubMedGoogle Scholar
• Calamandrei , G. , Venerosi , A. , Branchi , I. , Valanzano , A. , Puopolo , M. and Alleva , E. 1999 . Neurobehavioral effects of prenatal lamivudine (3TC) exposure in preweaning mice . Neurotoxicol. Teratol. , 21 : 365 – 73 .
   PubMed Web of Science ®Google Scholar
• Carr , R. L. , Chambers , H. W. , Guarisco , J. A. , Richardson , J. R. , Tang , J. and Chambers , J. E. 2001 . Effects of repeated oral postnatal exposure to chlorpyrifos on open-field behavior in juvenile rats . Toxicol. Sci. , 59 : 260 – 67 .
   PubMed Web of Science ®Google Scholar
• Carr , R. L. and Nail , C. A. 2008 . Effect of different administration paradigms on cholinesterase inhibition following repeated chlorpyrifos exposure in late preweanling rats . Toxicol. Sci. , 106 : 186 – 92 .
   PubMed Web of Science ®Google Scholar
• Chakraborti , T. K. , Farrar , J. D. and Pope , C. N. 1993 . Comparative neurochemical and neurobehavioral effects of repeated chlorpyrifos exposures in young and adult rats . Pharmacol. Biochem. Behav. , 46 : 219 – 24 .
   PubMed Web of Science ®Google Scholar
• Chanda , S. M. and Pope , C. N. 1996 . Neurochemical and neurobehavioral effects of repeated gestational exposure to chlorpyrifos in maternal and developing rats . Pharmacol. Biochem. Behav. , 53 : 771 – 76 .
   PubMed Web of Science ®Google Scholar
• Chapin , R. E. , Adams , J. , Boekelheide , K. , Gray , L. E. Jr. , Hayward , S. W. , Lees , P. S. , McIntyre , B. S. , Portier , K. M. , Schnorr , T. M. , Selevan , S. G. , Vandenbergh , J. G. and Woskie , S. R. 2008 . NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A . Birth Defects Res. B Dev. Reprod. Toxicol. , 83 : 157 – 395 .
   PubMed Web of Science ®Google Scholar
• Clegg , D. J. and van Gemert , M. 1999a . Determination of the reference dose for chlorpyrifos: Proceedings of an expert panel . J. Toxicol. Environ. Health B , 2 : 211 – 55 .
   PubMed Web of Science ®Google Scholar
• Clegg , D. J. and van Gemert , M. 1999b . Expert panel report of human studies on chlorpyrifos and/or other organophosphate exposures . J. Toxicol. Environ. Health B , 2 : 257 – 79 .
   PubMed Web of Science ®Google Scholar
• Dam , K. , Garcia , S. J. , Seidler , F. J. and Slotkin , T. A. 1999 . Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways . Brain Res. Dev. Brain Res. , 116 : 9 – 20 .
   PubMedGoogle Scholar
• Dam , K. , Seidler , F. J. and Slotkin , T. A. 2000 . Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity . Brain Res. Dev. Brain Res. , 121 : 179 – 87 .
   PubMedGoogle Scholar
• DeSesso , J. M. , Watson , R. E. , Keen , C. L. , Hazelden , K. P. , Haws , L. C. and Li , A. A. 2009 . Analysis and integration of developmental neurotoxicity and ancillary data into risk assessment: A case study of dimethoate . J. Toxicol. Environ. Health A , 72 : 94 – 109 .
   PubMed Web of Science ®Google Scholar
• Eaton , D. L. , Daroff , R. B. , Autrup , H. , Bridges , J. , Buffler , P. , Costa , L. G. , Coyle , J. , McKhann , G. , Mobley , W. C. , Nadel , L. , Neubert , D. , Schulte-Hermann , R. and Spencer , P. S. 2008 . Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment . Crit. Rev. Toxicol. , 38 ( suppl. 2 ) : 1 – 125 .
   PubMed Web of Science ®Google Scholar
• Engel , S. M. , Berkowitz , G. S. , Barr , D. B. , Teitelbaum , S. L. , Siskind , J. , Meisel , S. J. , Wetmur , J. G. and Wolff , M. S. 2007 . Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort . Am. J. Epidemiol. , 165 : 1397 – 404 .
   PubMed Web of Science ®Google Scholar
• Eskenazi , B. , Bradman , A. and Castorina , R. 1999 . Exposures of children to organophosphate pesticides and their potential adverse health effects . Environ. Health Perspect. , 107 ( suppl. 3 ) : 409 – 19 .
   PubMed Web of Science ®Google Scholar
• Eskenazi , B. , Harley , K. , Bradman , A. , Weltzien , E. , Jewell , N. P. , Barr , D. B. , Furlong , C. E. and Holland , N. T. 2004 . Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population . Environ. Health Perspect. , 112 : 1116 – 24 .
   PubMed Web of Science ®Google Scholar
• Eskenazi , B. , Marks , A. R. , Bradman , A. , Harley , K. , Barr , D. B. , Johnson , C. , Morga , N. and Jewell , N. P. 2007 . Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children . Environ. Health Perspect. , 115 : 792 – 98 .
   PubMed Web of Science ®Google Scholar
• Eskenazi , B. , Rosas , L. G. , Marks , A. R. , Bradman , A. , Harley , K. , Holland , N. , Johnson , C. , Fenster , L. and Barr , D. B. 2008 . Pesticide toxicity and the developing brain . Basic Clin. Pharmacol. Toxicol. , 10 : 228 – 36 .
   Web of Science ®Google Scholar
• Garcia , S. J. , Seidler , F. J. , Qiao , D. and Slotkin , T. A. 2002 . Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein . Brain Res. Dev. Brain Res. , 133 : 151 – 61 .
   PubMedGoogle Scholar
• Greenland , S. 1998 . “ Analysis of polytomous exposures and outcomes ” . In Modern epidemiology , Philadelphia , PA : Lippincott-Raven . Kenneth J. Rothman and Sander Greenland
   Google Scholar
• Guo-Ross , S. X. , Chambers , J. E. , Meek , E. C. and Carr , R. L. 2007 . Altered muscarinic acetylcholine receptor subtype binding in neonatal rat brain following exposure to chlorpyrifos or methyl parathion . Toxicol. Sci. , 100 : 118 – 27 .
   PubMed Web of Science ®Google Scholar
• Haviland , J. A. , Butz , D. E. and Porter , W. P. 2010 . Long-term sex selective hormonal and behavior alterations in mice exposed to low doses of chlorpyrifos in utero . Reprod. Toxicol. , 29 : 74 – 79 .
   PubMed Web of Science ®Google Scholar
• Hertz-Picciotto , I. , Croen , L. A. , Hansen , R. , Jones , C. R. , van de Water , J. and Pessah , I. N. 2006 . The CHARGE study: An epidemiologic investigation of genetic and environmental factors contributing to autism . Environ. Health Perspect. , 114 : 1119 – 25 .
   PubMed Web of Science ®Google Scholar
• Hill , A. B. 1965 . The environment and disease: Association or causation? . Proc. R. Soc. Med. , 58 : 295 – 300 .
   PubMed Web of Science ®Google Scholar
• Holson , R. R. , Freshwater , L. , Maurissen , J. P. , Moser , V. C. and Phang , W. 2008 . Statistical issues and techniques appropriate for developmental neurotoxicity testing: A report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints . Neurotoxicol. Teratol. , 30 : 326 – 48 .
   PubMed Web of Science ®Google Scholar
• Holson , R. R. and Pearce , B. 1992 . Principles and pitfalls in the analysis of prenatal treatment effects in multiparous species . Neurotoxicol. Teratol. , 14 : 221 – 28 .
   PubMed Web of Science ®Google Scholar
• Icenogle , L. M. , Christopher , N. C. , Blackwelder , W. P. , Caldwell , D. P. , Qiao , D. , Seidler , F. J. , Slotkin , T. A. and Levin , E. D. 2004 . Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation . Neurotoxicol. Teratol. , 26 : 95 – 101 .
   PubMed Web of Science ®Google Scholar
• Jett , D. A. , Navoa , R. V. , Beckles , R. A. and McLemore , G. L. 2001 . Cognitive function and cholinergic neurochemistry in weanling rats exposed to chlorpyrifos . Toxicol. Appl. Pharmacol. , 174 : 89 – 98 .
   PubMed Web of Science ®Google Scholar
• Johnson , F. O. , Chambers , J. E. , Nail , C. A. , Givaruangsawat , S. and Carr , R. L. 2009 . Developmental chlorpyrifos and methyl parathion exposure alters radial-arm maze performance in juvenile and adult rats . Toxicol. Sci. , 109 : 132 – 42 .
   PubMed Web of Science ®Google Scholar
• Kelly , J. P. , Wrynn , A. S. and Leonard , B. E. 1997 . The olfactory bulbectomized rat as a model of depression: An update . Pharmacol. Ther. , 74 : 299 – 316 .
   PubMed Web of Science ®Google Scholar
• Lassiter , T. L. , Barone , S. Jr. , Moser , V. C. and Padilla , S. 1999 . Gestational exposure to chlorpyrifos: Dose response profiles for cholinesterase and carboxylesterase activity . Toxicol. Sci. , 52 : 92 – 100 .
   PubMed Web of Science ®Google Scholar
• Lassiter , T. L. , Padilla , S. , Mortensen , S. R. , Chanda , S. M. , Moser , V. C. and Barone , S. Jr. 1998 . Gestational exposure to chlorpyrifos: Apparent protection of the fetus? . Toxicol. Appl. Pharmacol. , 152 : 56 – 65 .
   PubMed Web of Science ®Google Scholar
• Lauder , J. M. and Schambra , U. B. 1999 . Morphogenetic roles of acetylcholine . Environ. Health Perspect. , 107 ( suppl. 1 ) : 65 – 69 .
   PubMedGoogle Scholar
• Laviola , G. , Adriani , W. , Gaudino , C. , Marino , R. and Keller , F. Paradoxical effects of prenatal acetylcholinesterase blockade on neuro-behavioral development and drug-induced stereotypies in reeler mutant mice . Psychopharmacology , 187 331 – 44 .
   PubMed Web of Science ®Google Scholar
• Levin , E. D. , Addy , N. , Baruah , A. , Elias , A. , Christopher , N. C. , Seidler , F. J. and Slotkin , T. A. 2002 . Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations . Neurotoxicol. Teratol. , 24 : 733 – 41 .
   PubMed Web of Science ®Google Scholar
• Levin , E. D. , Addy , N. , Nakajima , A. , Christopher , N. C. , Seidler , F. J. and Slotkin , T. A. 2001 . Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats . Brain Res. Dev. Brain Res. , 130 : 83 – 89 .
   PubMedGoogle Scholar
• Liu , J. , Olivier , K. and Pope , C. N. 1999 . Comparative neurochemical effects of repeated methyl parathion or chlorpyrifos exposures in neonatal and adult rats . Toxicol. Appl. Pharmacol. , 158 : 186 – 96 .
   PubMed Web of Science ®Google Scholar
• Liu , J. and Pope , C.N. 1998 . Comparative presynaptic neurochemical changes in rat striatum following exposure to chlorpyrifos or parathion . J. Toxicol. Environ. Health A , 53 : 531 – 44 .
   PubMed Web of Science ®Google Scholar
• Lowe , E. R. , Poet , T. S. , Rick , D. L. , Marty , M. S. , Mattsson , J. L. , Timchalk , C. and Bartels , M. J. 2009 . The effect of plasma lipids on the pharmacokinetics of chlorpyrifos and the impact on interpretation of blood biomonitoring data . Toxicol. Sci. , 108 : 258 – 72 .
   PubMed Web of Science ®Google Scholar
• Lu , C. , Bravo , R. , Caltabiano , L. M. , Irish , R. M. , Weerasekera , G. and Barr , D. B. 2005 . The presence of dialkylphosphates in fresh fruit juices: Implication for organophosphorus pesticide exposure and risk assessments . J. Toxicol. Environ. Health A , 68 : 209 – 27 .
   PubMed Web of Science ®Google Scholar
• Mar , A. , Spreekmeester , E. and Rochford , J. 2000 . Antidepressants preferentially enhance habituation to novelty in the olfactory bulbectomized rat . Psychopharmacology (Berlin) , 150 : 52 – 60 .
   PubMed Web of Science ®Google Scholar
• Marty , M. S. , Domoradzki , J. Y. , Hansen , S. C. , Timchalk , C. , Bartels , M. J. and Mattsson , J. L. 2007 . The effect of route, vehicle, and divided doses on the pharmacokinetics of chlorpyrifos and its metabolite trichloropyridinol in neonatal Sprague-Dawley rats . Toxicol. Sci. , 100 : 360 – 73 .
   PubMed Web of Science ®Google Scholar
• Mattsson , J. L. , Maurissen , J. P. , Nolan , R. J. and Brzak , K. A. 2000 . Lack of differential sensitivity to cholinesterase inhibition in fetuses and neonates compared to dams treated perinatally with chlorpyrifos . Toxicol. Sci. , 53 : 438 – 46 .
   PubMed Web of Science ®Google Scholar
• Maurissen , J. 2010 . Practical considerations on the design, execution and analysis of developmental neurotoxicity studies . Neurotoxicol. Teratol. , 32 : 121 – 23 .
   PubMed Web of Science ®Google Scholar
• Maurissen , J. P. , Hoberman , A. M. , Garman , R. H. and Hanley , T. R. Jr. 2000 . Lack of selective developmental neurotoxicity in rat pups from dams treated by gavage with chlorpyrifos . Toxicol. Sci. , 57 : 250 – 63 .
   PubMed Web of Science ®Google Scholar
• Moser , V. C. , Chanda , S. M. , Mortensen , S. R. and Padilla , S. 1998 . Age- and gender-related differences in sensitivity to chlorpyrifos in the rat reflect developmental profiles of esterase activities . Toxicol. Sci. , 46 : 211 – 22 .
   PubMed Web of Science ®Google Scholar
• Moser , V. C. and Padilla , S. 1998 . Age- and gender-related differences in the time course of behavioral and biochemical effects produced by oral chlorpyrifos in rats . Toxicol. Appl. Pharmacol. , 149 : 107 – 19 .
   PubMed Web of Science ®Google Scholar
• Muto , M. A. , Lobelle , F. , Bidanset , J. H. and Wurpel , J. N. D. 1992 . Embryotoxicity and neurotoxicity in rats associated with prenatal exposure to dursban . Vet. Hum. Toxicol. , 34 : 498 – 501 .
   PubMedGoogle Scholar
• Needham , L. L. 2005 . Assessing exposure to organophosphorus pesticides by biomonitoring in epidemiologic studies of birth outcomes . Environ. Health Perspect. , 113 : 494 – 98 .
   PubMed Web of Science ®Google Scholar
• Official Journal of the European Union Legislation L . 2007 . 50 ( part 216 ) : 17 – 21 .
   Google Scholar
• Perera , F. P. , Rauh , V. , Tsai , W. Y. , Kinney , P. , Camann , D. , Barr , D. , Bernert , T. , Garfinkel , R. , Tu , Y. H. , Diaz , D. , Dietrich , J. and Whyatt , R. M. 2003 . Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population . Environ. Health Perspect. , 111 : 201 – 5 .
   PubMed Web of Science ®Google Scholar
• Poole , C. 2001 . Low P-values or narrow confidence intervals: Which are more durable? . Epidemiology , 12 : 291 – 94 .
   PubMed Web of Science ®Google Scholar
• Pope , C.N. and Chakraborti , T.K. 1992 . Dose-related inhibition of brain and plasma cholinesterase in neonatal and adult rats following sublethal organophosphate exposures . Toxicology , 73 : 35 – 43 .
   PubMed Web of Science ®Google Scholar
• Pope , C. N. 1999 . Organophosphorus pesticides: Do they all have the same mechanism of toxicity? . J. Toxicol. Environ. Health B Crit. Rev. , 2 : 161 – 81 .
   PubMed Web of Science ®Google Scholar
• Qiao , D. , Seidler , F. J. , Abreu-Villaca , Y. , Tate , C. A. , Cousins , M. M. and Slotkin , T. A. 2004 . Chlorpyrifos exposure during neurulation: Cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood . Brain Res. Dev. Brain Res. , 148 : 43 – 52 .
   PubMedGoogle Scholar
• Qiao , D. , Seidler , F. J. , Padilla , S. and Slotkin , T. A. 2002 . Developmental neurotoxicity of chlorpyrifos: What is the vulnerable period? . Environ. Health Perspect. , 110 : 1097 – 103 .
   PubMed Web of Science ®Google Scholar
• Qiao , D. , Seidler , F. J. , Tate , C. A. , Cousins , M. M. and Slotkin , T. A. 2003 . Fetal chlorpyrifos exposure: Adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood . Environ. Health Perspect. , 111 : 536 – 44 .
   PubMed Web of Science ®Google Scholar
• Raines , K. W. , Seidler , F. J. and Slotkin , T. A. 2001 . Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos . Brain Res. Dev. Brain Res. , 130 : 65 – 72 .
   PubMedGoogle Scholar
• Rauh , V. A. , Garfinkel , R. , Perera , F. P. , Andrews , H. F. , Hoepner , L. , Barr , D. B. , Whitehead , R. , Tang , D. and Whyatt , R. W. 2006 . Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children . Pediatrics , 118 : 1845 – 59 .
   PubMed Web of Science ®Google Scholar
• Rescorla , L. A. 2005 . Assessment of young children using the Achenbach System of Empirically Based Assessment (ASEBA) . Mental Retard. Dev. Disabil. Res. Rev. , 11 : 226 – 37 .
   PubMedGoogle Scholar
• Ricceri , L. , Markina , N. , Valanzano , A. , Fortuna , S. , Cometa , M. F. , Meneguz , A. and Calamandrei , G. 2003 . Developmental exposure to chlorpyrifos alters reactivity to environmental and social cues in adolescent mice . Toxicol. Appl. Pharmacol. , 191 : 189 – 201 .
   PubMed Web of Science ®Google Scholar
• Ricceri , L. , Venerosi, Capone , A., F. , Cometa , M. F. , Lorenzini , P. , Fortuna , S. and Calamandrei , G. 2006 . Developmental neurotoxicity of organophosphorous pesticides: Fetal and neonatal exposure to chlorpyrifos alters sex-specific behaviors at adulthood in mice . Toxicol. Sci. , 93 : 105 – 13 .
   PubMed Web of Science ®Google Scholar
• Richardson , J. and Chambers , J. 2003 . Effects of gestational exposure to chlorpyrifos on postnatal central and peripheral cholinergic neurochemistry . J. Toxicol. Environ. Health A , 66 : 275 – 89 .
   PubMed Web of Science ®Google Scholar
• Richardson , J. R. and Chambers , J. E. 2004 . Neurochemical effects of repeated gestational exposure to chlorpyrifos in developing rats . Toxicol. Sci. , 77 : 83 – 90 .
   PubMed Web of Science ®Google Scholar
• Richardson , J. R. and Chambers , J. E. 2005 . Effects of repeated oral postnatal exposure to chlorpyrifos on cholinergic neurochemistry in developing rats . Toxicol. Sci. , 84 : 352 – 59 .
   PubMed Web of Science ®Google Scholar
• Roegge , C. S. , Timofeeva , O. A. , Seidler , F. J. , Slotkin , T. A. and Levin , E. D. 2008 . Developmental diazinon neurotoxicity in rats: Later effects on emotional response . Brain Res. Bull. , 75 : 166 – 72 .
   PubMed Web of Science ®Google Scholar
• Rosecrans , J. A. , Johnson , J. H. , Tilson , H. A. and Hong , J. S. 1984 . Hypothalamic-pituitary adrenal (HPAA) axis function in adult Fischer-344 rats exposed during development to neurotoxic chemicals perinatally . Neurobehav. Toxicol. Teratol. , 6 : 281 – 88 .
   PubMedGoogle Scholar
• Roy , T. S. , Seidler , F. J. and Slotkin , T. A. 2004 . Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain: Regionally selective alterations in neurons and glia . Brain Res. Dev. Brain Res. , 148 : 197 – 206 .
   PubMedGoogle Scholar
• Roy , T. S. , Sharma , V. , Seidler , F. J. and Slotkin , T. A. 2005 . Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats . Brain Res. Dev. Brain Res. , 155 : 71 – 80 .
   PubMedGoogle Scholar
• Sattler , J. M. 2001 . Assessment of children: Cognitive applications , 4th , La Mesa , CA : Jerome M. Sattler .
   Google Scholar
• Scher , D. P. , Alexander , B. H. , Adgate , J. L. , Eberly , L. E. , Mandel , J. S. , Acquavella , J. F. , Bartels , M. J. and Brzak , K. A. 2007 . Agreement of pesticide biomarkers between morning void and 24-h urine samples from farmers and their children . J. Expos. Sci. Environ. Epidemiol. , 17 : 350 – 57 .
   PubMed Web of Science ®Google Scholar
• Slotkin , T. A. 2004 . Guidelines for developmental neurotoxicity and their impact on organophosphate pesticides: A personal view from an academic perspective . Neurotoxicology , 25 : 631 – 40 .
   PubMed Web of Science ®Google Scholar
• Slotkin , T. A. , Cousins , M. M. , Tate , C. A. and Seidler , F. J. 2001 . Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure . Brain Res. , 902 : 229 – 43 .
   PubMed Web of Science ®Google Scholar
• Slotkin , T. A. , Levin , E. D. and Seidler , F. J. 2006 . Comparative developmental neurotoxicity of organophosphate insecticides: Effects on brain development are separable from systemic toxicity . Environ. Health Perspect. , 114 : 746 – 51 .
   PubMed Web of Science ®Google Scholar
• Slotkin , T. A. , Miller , D. B. , Fumagalli , F. , McCook , E. C. , Zhang , J. , Bissette , G. and Seidler , F. J. 1999 . Modeling geriatric depression in animals: Biochemical and behavioral effects of olfactory bulbectomy in young versus aged rats . J. Pharmacol. Exp. Ther. , 289 : 334 – 45 .
   PubMed Web of Science ®Google Scholar
• Slotkin , T. A. and Seidler , F. J. 2005 . The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent . Brain Res. Dev. Brain Res. , 158 : 115 – 19 .
   PubMedGoogle Scholar
• Slotkin , T. A. and Seidler , F. J. 2007a . Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: Critical periods for regional and sex-selective effects . Reprod. Toxicol. , 23 : 421 – 27 .
   PubMed Web of Science ®Google Scholar
• Slotkin , T. A. and Seidler , F. J. 2007b . Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats . Brain Res. Bull. , 73 : 301 – 9 .
   PubMed Web of Science ®Google Scholar
• Slotkin , T.A. , Southard , M.C. , Adam , S.J. , Cousins , M.M. and Seidler , F.J. 2004 . α7 Nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: Nicotine and chlorpyrifos . Brain Res. Bull. , 64 : 227 – 35 .
   PubMed Web of Science ®Google Scholar
• Slotkin , T. A. , Tate , C. A. , Cousins , M. M. and Seidler , F. J. 2002 . Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure . Brain Res. Dev. Brain Res. , 133 : 163 – 73 .
   PubMedGoogle Scholar
• Smith , J. N. , Campbell , J. A. , Busby-Hjerpe , A. L. , Lee , S. , Poet , T. S. , Barr , D. B. and Timchalk , C. 2009 . Comparative chlorpyrifos pharmacokinetics via multiple routes of exposure and vehicles of administration in adult rats . Toxicology , 261 : 47 – 58 .
   PubMed Web of Science ®Google Scholar
• Song , X. , Seidler , F. J. , Saleh , J. L. , Zhang , J. , Padilla , S. and Slotkin , T. A. 1997 . Cellular mechanisms for developmental toxicity of chlorpyrifos: Targeting the adenylyl cyclase signaling cascade . Toxicol. Appl. Pharmacol. , 145 : 158 – 74 .
   PubMed Web of Science ®Google Scholar
• Strauss , E. , Sherman , E. M. S. and Spreen , O. 2006 . A compendium of neuropsychological tests: Administration, norms and commentary , 3rd , New York, NY : Oxford University Press .
   Google Scholar
• Tang , J. , Carr , R. L. and Chambers , J. E. 1999 . Changes in rat brain cholinesterase activity and muscarinic receptor density during and after repeated oral exposure to chlorpyrifos in early postnatal development . Toxicol. Sci. , 51 : 265 – 72 .
   PubMed Web of Science ®Google Scholar
• Tang , J. , Carr , R. L. and Chambers , J. E. 2003 . The effects of repeated oral exposures to methyl parathion on rat brain cholinesterase and muscarinic receptors during postnatal development . Toxicol. Sci. , 76 : 400 – 6 .
   PubMed Web of Science ®Google Scholar
• Timchalk , C. , Nolan , R. J. , Mendrala , A. L. , Dittenber , D. A. , Brzak , K. A. and Mattsson , J. L. 2002 . A physiologically based pharmacokinetic and pharacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans . Toxicol. Sci. , 66 : 34 – 53 .
   PubMed Web of Science ®Google Scholar
• Timchalk , C. , Poet , T. S. and Kousba , A. A. 2006 . Age-dependent pharmacokinetic and pharmacodynamic response in preweanling rats following oral exposure to the organophosphorus insecticide chlorpyrifos . Toxicology , 220 : 13 – 25 .
   PubMed Web of Science ®Google Scholar
• Timofeeva , O. A. , Roegge , C. S. , Seidler , F. J. , Slotkin , T. A. and Levin , E. D. 2008 . Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon . Neurotoxicol. Teratol. , 30 : 38 – 45 .
   PubMed Web of Science ®Google Scholar
• Uphouse , L. , Mason , G. and Bondy , S. 1982 . Comments concerning the use of dimethylsulfoxide as a solvent for studies of chlordecone neurotoxicity . Neurotoxicology , 3 : 149 – 54 .
   PubMed Web of Science ®Google Scholar
• U.S. Environmental Protection Agency. 1998a. Health effects test guidelines OPPTS 870.6300. Developmental neurotoxicity study. http://www.epa.gov/ocspp/pubs/frs/publications/Test_Guidelines/series870.htm (http://www.epa.gov/ocspp/pubs/frs/publications/Test_Guidelines/series870.htm) (Accessed: 1 November 2011 ).
   Google Scholar
• U.S. Environmental Protection Agency. 1998b. Guidelines for neurotoxicity risk assessment. http://www.epa.gov/fedrgstr/EPA-TOX/1998/May/Day-14/t12303.htm (http://www.epa.gov/fedrgstr/EPA-TOX/1998/May/Day-14/t12303.htm) (Accessed: 27 July 2011 ).
   Google Scholar
• U.S. Environmental Protection Agency . 1999 . Agricultural and occupational exposure assessment and recommendations for the re-registration eligibility decision document for chlorpyrifos , Washington , DC : U.S. Environmental Protection Agency, Office of Prevention, Pesticides, and Toxic Substances .
   Google Scholar
• U.S. Environmental Protection Agency. 2002. U.S. Environmental Protection Agency Office of Pesticide Programs reregistration eligibility decision for chlorpyrifos 2002. http://www.epa.gov/opp00001/reregistration/REDs/chlorpyrifos_red.pdf (http://www.epa.gov/opp00001/reregistration/REDs/chlorpyrifos_red.pdf) (Accessed: 21 July 2011 ).
   Google Scholar
• U.S. Environmental Protection Agency. 2010 Framework for incorporating human epidemiologic & incident data in health risk assessment. SAP review draft. U.S. Environmental Protection Agency, Office of Pesticide Programs http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPP-2009-0851-0004 (http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPP-2009-0851-0004) (Accessed: 30 August 2011 ).
   Google Scholar
• U.S. Environmental Protection Agency. 2011. Chlorpyrifos: Preliminary human health risk assessment for registration. U.S. Environmental Protection Agency, Office of Chemical Safety and Pollution Prevention http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPP-2008-0850-0025. (http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPP-2008-0850-0025.) (Accessed: 9 August 2011 ).
   Google Scholar
• Venerosi , A. , Calamandrei , G. and Ricceri , L. 2006 . A social recognition test for female mice reveals behavioral effects of developmental chlorpyrifos exposure . Neurotoxicol. Teratol. , 28 : 466 – 71 .
   PubMed Web of Science ®Google Scholar
• Venerosi , A. , Cutuli , D. , Colonnello , V. , Cardona , D. , Ricceri , L. and Calamandrei , G. 2008 . Neonatal exposure to chlorpyrifos affects maternal responses and maternal aggression of female mice in adulthood . Neurotoxicol. Teratol. , 30 : 468 – 74 .
   PubMed Web of Science ®Google Scholar
• Venerosi , A. , Ricceri , L. , Rungi , A. , Sanghez , V. and Calamandrei , G. 2010 . Gestational exposure to the organophosphate chlorpyrifos alters social-emotional behaviour and impairs responsiveness to the serotonin transporter inhibitor fluvoxamine in mice . Psychopharmacology (Berlin) , 208 : 99 – 107 .
   PubMed Web of Science ®Google Scholar
• Venerosi , A. , Ricceri , L. , Scattoni , M. L. and Calamandrei , G. 2009 . Prenatal chlorpyrifos exposure alters motor behavior and ultrasonic vocalization in CD-1 mouse pups . Environ. Health , 8 : 12
   PubMed Web of Science ®Google Scholar
• Weselak , M. , Arbuckle , T. E. and Foster , W. 2007 . Pesticide exposures and developmental outcomes: The epidemiological evidence . J. Toxicol. Environ. Health B Crit. Rev. , 10 : 41 – 80 .
   PubMed Web of Science ®Google Scholar
• Whyatt , R. M. , Camann , D. , Perera , F. P. , Rauh , V. A. , Tang , D. , Kinney , P. L. , Garfinkel , R. , Andrews , H. , Hoepner , L. and Barr , D. B. 2005 . Biomarkers in assessing residential insecticide exposures during pregnancy and effects on fetal growth . Toxicol. Appl. Pharmacol. , 206 : 246 – 54 .
   PubMed Web of Science ®Google Scholar
• Whyatt , R. M. , Garfinkel , R. , Hoepner , L. A. , Andrews , H. , Holmes , D. , Williams , M. K. , Reyes , A. , Diaz , D. , Perera , F. P. , Camann , D. E. and Barr , D. B. 2009 . A biomarker validation study of prenatal chlorpyrifos exposure within an inner-city cohort during pregnancy . Environ. Health Perspect. , 117 : 559 – 67 .
   PubMed Web of Science ®Google Scholar
• Whyatt , R. M. , Rauh , V. , Barr , D. B. , Camann , D. E. , Andrews , H. F. , Garfinkel , R. , Hoepner , L. A. , Diaz , D. , Dietrich , J. , Reyes , A. , Tang , D. , Kinney , P. L. and Perera , F. P. 2004 . Prenatal insecticide exposures and birth weight and length among an urban minority cohort . Environ. Health Perspect. , 112 : 1125 – 32 .
   PubMed Web of Science ®Google Scholar
• Young , J. G. , Eskenazi , B. , Gladstone , E. A. , Bradman , A. , Pedersen , L. , Johnson , C. , Barr , D. B. , Furlong , C. E. and Holland , N. T. 2005 . Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates . Neurotoxicology , 26 : 199 – 209 .
   PubMed Web of Science ®Google Scholar
• Zamora , E.M.U. , Liu , J. and Pope , C. N. 2008 . Effects of chlorpyrifos oxon on M2 muscarinic receptor internalization in different cell types . J. Toxicol. Environ. Health A , 71 : 1440 – 47 .
   PubMed Web of Science ®Google Scholar
• Zhang , H. , Liu , J. and Pope , C. N. 2002 . Age-related effects of chlorpyrifos on muscarinic receptor-mediated signaling in rat cortex . Arch. Toxicol. , 75 : 676 – 84 .
   PubMed Web of Science ®Google Scholar
• Zheng , Q. , Olivier , K. , Won , Y. K. and Pope , C. N. 2000 . Comparative cholinergic neurotoxicity of oral chlorpyrifos exposures in preweanling and adult rats . Toxicol. Sci. , 55 : 124 – 32 .
   PubMed Web of Science ®Google Scholar