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Review

A critical review of talc and ovarian cancer

References

  • American Cancer Society (ACS). 2019. Ovarian cancer. https://www.cancer.org/cancer/ovarian-cancer.html.
  • American Conference of Governmental Industrial Hygienists (ACGIH). 2010. Documentation for talc (CAS No. 14807-96-6). In Documentation of the threshold limit values and biological exposure indices, 7th ed., 12. Cincinnati, OH: American Conference of Governmental Industrial Hygienists (ACGIH).
  • Baiu, I., E. Yevudza, and J. B. Shrager. 2019. Talc pleurodesis: A medical, medicolegal, and socioeconomic review. Ann. Thorac. Surg. doi:10.1016/j.anthroacsur.2019.08.104.
  • Boffetta, P., J. K. McLaughlin, C. La Vecchia, R. E. Tarone, L. Lipworth, and W. J. Blot. 2008. False-positive results in cancer epidemiology: A plea for epistemological modesty. J. Natl. Cancer Inst. 100:988–95. doi:10.1093/jnci/djn191.
  • Boffetta, P., K. A. Mundt, and W. J. Thompson. 2018. The epidemiologic evidence for elongate mineral particle (EMP)-related human cancer risk. Toxicol. Appl. Pharmacol. 361:100–06. doi:10.1016/j.taap.2018.09.021.
  • Boorman, G. A., and J. C. Seely. 1995. The lack of an ovarian effect of lifetime talc exposure in F344/N rats and B6C3F1 mice. Regul. Toxicol. Pharmacol. 2:242–43. doi:10.1006/rtph.1995.1035.
  • Booth, M., V. Beral, and P. Smith. 1989. Risk factors for ovarian cancer: A case-control study. Br. J. Cancer 60:592–98. doi:10.1038/bjc.1989.320.
  • Buz’Zard, A. R., and B. H. Lau. 2007. Pycnogenol reduces talc-induced neoplastic transformation in human ovarian cell cultures. Phytother. Res. 21:579–86. doi:10.1002/ptr.2117.
  • Carr, C. J. 1995. Talc: Consumer uses and health perspectives. Regul. Toxicol. Pharmacol. 21:211–15. doi:10.1006/rtph.1995.1030.
  • Celsi, F., S. Crovella, R. R. Moura, M. Schneider, F. Vita, L. Finotto, G. Zabucchi, P. Zacchi, and V. Borelli. 2019. Pleural mesothelioma and lung cancer: The role of asbestos exposure and genetic varants in selected iron metabolism and inflammation genes. J. Toxicol. Environ. Health Part A 82:1088–102. doi:10.1080/15287394.2019.1694612.
  • Centers for Disease Control and Prevention (CDC). 2015. What are the risk factors for ovarian cancer? December 8. https://www.cdc.gov/cancer/ovarian/basic_info/risk_factors.htm
  • Centers for Disease Control and Prevention (CDC). 2016. NIOSH pocket guide to chemical hazards record for talc (containing no asbestos and less than 1% quartz) (CAS No. 14807-96-6). April 11. https://www.cdc.gov/niosh/npg/npgd0584.html.
  • Chang, S., and H. A. Risch. 1997. Perineal talc exposure and risk of ovarian carcinoma. Cancer 79:2396–401. doi:10.1002/(SICI)1097-0142(19970615)79:12<2396::AID-CNCR15>3.0.CO;2-M.
  • Chatfield, E. J. 2018. Measurement of elongate mineral particles: What we should measure and how do we do it? Toxicol. Appl. Pharmacol. 361:36–46. doi:10.1016/j.taap.2018.08.010.
  • Chen, Y., P. C. Wu, J. H. Lang, W. J. Ge, P. Hartge, and L. A. Brinton. 1992. Risk factors for epithelial ovarian cancer in Beijing, China. Int. J. Epidemiol. 21:23–29. doi:10.1093/ije/21.1.23.
  • Cook, L. S., M. L. Kamb, and N. S. Weiss. 1997. Perineal powder exposure and the risk of ovarian cancer. Am. J. Epidemiol. 145:459–65. doi:10.1093/oxfordjournals.aje.a009128.
  • Coultas, D. B., C. A. Howard, G. T. Peake, B. J. Skipper, and J. M. Samet. 1988. Discrepancies between self-reported smoking and validated cigarette smoking in a community survey of New Mexico Hispanics. Am. Rev. Respir. Dis. 137:810–14. doi:10.1164/ajrccm/137.4.810.
  • Cramer, D. W. 2012. The epidemiology of endometrial and ovarian cancer. Hematol. Oncol. Clin. North Am. 26:1–12. doi:10.1016/j.hoc.2011.10.009.
  • Cramer, D. W., and O. J. Finn. 2011. Epidemiologic perspective on immune-surveillance in cancer. Curr. Opin. Immunol. 23:265–71. doi:10.1016/j.coi.2011.01.002.
  • Cramer, D. W., R. F. Liberman, L. Titus-Ernstoff, W. R. Welch, E. R. Greenberg, J. A. Baron, and B. L. Harlow. 1999. Genital talc exposure and risk of ovarian cancer. Int. J. Cancer 81:351–56. doi:10.1002/(SICI)1097-0215(19990505)81:3<351::AID-IJC7>3.0.CO;2-M.
  • Cramer, D. W., A. F. Vitonis, K. L. Terry, W. R. Welch, and L. J. Titus. 2016. The association between talc use and ovarian cancer: A retrospective case-control study in two US states. Epidemiology 27:334–46. doi:10.1097/EDE.0000000000000434.
  • Cramer, D. W., W. R. Welch, R. S. Berkowitz, and J. J. Godleski. 2007. Presence of talc in pelvic lymph nodes of a woman with ovarian cancer and long-term genital exposure to cosmetic talc. Obstet. Gynecol. 110:498–501. doi:10.1097/01.AOG.0000262902.80861.a0.
  • Cramer, D. W., W. R. Welch, R. E. Scully, and C. A. Wojciechowski. 1982. Ovarian cancer and talc: A case-control study. Cancer 50:372–76. doi:10.1002/1097-0142(19820715)50:2<372::AID-CNCR2820500235>3.0.CO;2-S.
  • Cramer, D. W., and H. Xu. 1995. Epidemiologic evidence for uterine growth factors in the pathogenesis of ovarian cancer. Ann. Epidemiol. 5:310–14. doi:10.1016/1047-2797(94)00098-E.
  • Crane, D. T. 2018. OSHA and elongate mineral particles. Toxicol. Appl. Pharmacol. 361:165–67. doi:10.1016/j.taap.2018.08.017.
  • De Boer, C. H. 1972. Transport of particulate matter through the human female genital tract. J. Reprod. Fertil. 28:295–97. doi:10.1530/jrf.0.0280295.
  • de Brito, T., and M. F. Franco. 1994. Granulomatous inflammation. Rev. Inst. Med. Trop. Sao Paulo 36:185–92. doi:10.1590/s0036-46651994000200016.
  • Dodson, R. F. 2016. Preface: Respirable elongated mineral partices and human health-revisited. J. Toxicol Environ. Health B 19:149–50. doi:10.1080/10937404.2016.1193358.
  • Edelstam, G. A., A. C. Sjosten, and H. Ellis. 1997. Retrograde migration of starch in the genital tract of rabbits. Inflammation 21:489–99. doi:10.1023/A:1027307612999.
  • Egli, G. E., and M. Newton. 1961. The transport of carbon particles in the human female reproductive tract. Fertil. Steril. 12:151–55. doi:10.1016/S0015-0282(16)34084-5.
  • Endo-Capron, S., A. Renier, X. Janson, L. Kheuang, and M. C. Jaurand. 1993. In vitro response of rat pleural mesothelial cells to talc samples in genotoxicity assays (sister chromatid exchanges and DNA repair). Toxicol. In Vitro 7:7–14. doi:10.1016/0887-2333(93)90107-G.
  • Engel, L. S., N. S. Seixas, M. C. Keifer, W. T. Longstreth Jr., and H. Checkoway. 2001. Validity study of self-reported pesticide exposure among orchardists. J. Expo. Anal. Environ. Epidemiol. 11:359–68. doi:10.1038/sj.jea.7500176.
  • Fiume, M. M., I. Boyer, W. Bergfeld, D. V. Belsito, C. D. Klaassen, D. C. Liebler, J. G. Marks Jr., R. C. Shank, T. J. Slaga, P. W. Snyder, et al. 2015. Safety assessment of talc as used in cosmetics. Int. J. Toxicol 34 (Suppl. 1):66S–129S. doi:10.1177/1091581815586797.
  • Fletcher, N. M., A. K. Harper, I. Memaj, R. Fan, R. T. Morris, and G. M. Saed. 2019. Molecular basis supporting the association of talcum powder use with increased risk of ovarian cancer. Reprod. Sci. doi:10.1177/1933719119831773.
  • Friemann, J., C. Albrecht, P. Breuer, R. Grover, and C. Weishaupt. 1999. Time-course analysis of type II cell hyperplasia and alveolar bronchiolization in rats treated with different particulates. Inhal. Toxicol. 11:837–54. doi:10.1080/089583799196763.
  • Gabriel, I. M., A. F. Vitonis, W. R. Welch, L. Titus, and D. W. Cramer. 2019. Douching, talc use, and risk for ovarian cancer and conditions related to genital tract inflammation. Cancer Epidemiol. Biomarkers Prev. 28 (11):1835–44. doi:10.1158/1055-9965.EPI-19-0375.
  • Garabrant, D. H., and S. T. Pastula. 2018. A comparison of asbestos fiber potency and elongate mineral particle (EMP) potency for mesothelioma in humans. Toxicol. Appl. Pharmacol. 361:127–36. doi:10.1016/j.taap.2018.07.003.
  • Gates, M. A., B. A. Rosner, J. L. Hecht, and S. S. Tworoger. 2010. Risk factors for epithelial ovarian cancer by histologic subtype. Am. J. Epidemiol. 171:45–53. doi:10.1093/aje/kwp314.
  • Gates, M. A., S. S. Tworoger, K. L. Terry, L. Titus-Ernstoff, B. Rosner, I. De Vivo, D. W. Cramer, and S. E. Hankinson. 2008. Talc use, variants of the GSTM1, GSTT1, and NAT2 genes, and risk of epithelial ovarian cancer. Cancer Epidemiol. Biomarkers Prev. 17:2436–44. doi:10.1158/1055-9965.EPI-08-0399.
  • Gertig, D. M., D. J. Hunter, D. W. Cramer, G. A. Colditz, F. E. Speizer, W. C. Willett, and S. E. Hankinson. 2000. Prospective study of talc use and ovarian cancer. J. Natl. Cancer Inst. 92:249–52. doi:10.1093/jnci/92.3.249.
  • Godard, B., W. D. Foulkes, D. Provencher, J. S. Brunet, P. N. Tonin, A. M. Mes-Masson, S. A. Narod, and P. Ghadirian. 1998. Risk factors for familial and sporadic ovarian cancer among French Canadians: A case-control study. Am. J. Obstet. Gynecol. 179:403–10. doi:10.1016/S0002-9378(98)70372-2.
  • Gonzalez, N. L., K. M. O’Brien, A. A. D’Aloisio, D. P. Sandler, and C. R. Weinberg. 2016. Douching, talc use, and risk of ovarian cancer. Epidemiology 27:797–802. doi:10.1097/EDE.0000000000000528.
  • Goodman, J., and H. Lynch. 2017. Improving the international agency for research on cancer’s consideration of mechanistic evidence. Toxicol. Appl. Pharmacol. 319:39–46. doi:10.1016/j.taap.2017.01.020.
  • Goodman, J. I. 1995. An analysis of the national toxicology program’s (NTP) technical report NTP TR 421) on the toxicology and carcinogenesis studies of talc. Regul.Toxicol. Pharmacol. 21:244–49. doi:10.1006/rtph.1995.1036.
  • Green, A., D. Purdie, C. Bain, V. Siskind, P. Russell, M. Quinn, and B. Ward. 1997. Tubal sterilisation, hysterectomy and decreased risk of ovarian cancer. Survey of women’s health study group. Int. J. Cancer 71:948–51. doi:10.1002/(SICI)1097-0215(19970611)71:6<948::AID-IJC6>3.0.CO;2-Y.
  • Greenland, S., and T. L. Lash. 2008. Bias analysis. In Modern epidemiology, ed. K. J. Rothman, S. Greenland, and T. L. Lash, 345–80. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins.
  • Greenland, S., and K. O’Rourke. 2008. Meta-analysis. In Modern epidemiology, ed. K. J. Rothman, S. Greenland, and T. L. Lash, 652–82. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins.
  • Gross, A. J., and P. H. Berg. 1995. A meta-analytical approach examining the potential relationship between talc exposure and ovarian cancer. J. Expo. Anal. Environ. Epidemiol. 5:181–95.
  • Gunter, M. E. 2018. Elongate mineral particles in the natural environment. Toxicol.Appl. Pharmacol. 361:157–64. doi:10.1016/j.taap.2018.09.024.
  • Hamilton, T. C., H. Fox, C. H. Buckley, W. J. Henderson, and K. Griffiths. 1984. Effects of talc on the rat ovary. Br. J. Exp. Pathol. 65:101–06.
  • Hankinson, S. E., and K. N. Danforth. 2006. Ovarian cancer. In Cancer epidemiology and prevention, ed. D. Schottenfeld, and J. F. Fraumeni, 1013–26. 3rd ed. New York: Oxford University Press.
  • Harlow, B. L., D. W. Cramer, D. A. Bell, and W. R. Welch. 1992. Perineal exposure to talc and ovarian cancer risk. Obstet. Gynecol. 80:19–26.
  • Harlow, B. L., and N. S. Weiss. 1989. A case-control study of borderline ovarian tumors: The influence of perineal exposure to talc. Am. J. Epidemiol. 130:390–94. doi:10.1093/oxfordjournals.aje.a115345.
  • Hartge, P., R. Hoover, L. P. Lesher, and L. McGowan. 1983. Talc and ovarian cancer (Letter). J Am Med Assoc 25014:1844. doi:10.1001/jama.1983.03340140020020.
  • Heller, D. S., C. Westhoff, R. E. Gordon, and N. Katz. 1996. The relationship between perineal cosmetic talc usage and ovarian talc particle burden. Am. J. Obstet. Gynecol. 174:1507–10. doi:10.1016/S0002-9378(96)70597-5.
  • Henderson, W. J., T. C. Hamilton, M. S. Baylis, C. G. Pierrepoint, and K. Griffiths. 1986. The demonstration of the migration of talc from the vagina and posterior uterus to the ovary in the rat. Environ. Res. 40:247–50. doi:10.1016/S0013-9351(86)80100-1.
  • Henderson, W. J., T. C. Hamilton, and K. Griffiths. 1979. Talc in normal and malignant ovarian tissue (Letter). Lancet 1:499. doi:10.1016/S0140-6736(79)90861-4.
  • Henderson, W. J., C. A. Joslin, A. C. Turnbull, and K. Griffiths. 1971. Talc and carcinoma of the ovary and cervix. J. Obstet. Gynaecol. Br. Commonwealth. 78:266–72. doi:10.1111/j.1471-0528.1971.tb00267.x.
  • Houghton, S. C., K. W. Reeves, S. E. Hankinson, L. Crawford, D. Lane, J. Wactawski-Wende, C. A. Thomson, J. K. Ockene, and S. R. Sturgeon. 2014. Perineal powder use and risk of ovarian cancer. J. Natl. Cancer Inst. 106:dju208. doi:10.1093/jnci/dju208.
  • Huncharek, M., J. F. Geschwind, and B. Kupelnick. 2003. Perineal application of cosmetic talc and risk of invasive epithelial ovarian cancer: A meta-analysis of 11,933 subjects from sixteen observational studies. Anticancer Res. 23:1955–60.
  • Huncharek, M., and J. Muscat. 2011. Perineal talc use and ovarian cancer risk: A case study of scientific standards in environmental epidemiology. Eur. J. Cancer Prev. 20:501–07. doi:10.1097/CEJ.0b013e3283476242.
  • Huncharek, M., J. Muscat, A. Onitilo, and B. Kupelnick. 2007. Use of cosmetic talc on contraceptive diaphragms and risk of ovarian cancer: A meta-analysis of nine observational studies. Eur. J. Cancer Prev. 16:422–29. doi:10.1097/01.cej.0000236257.03394.4a.
  • Hunn, J., and G. C. Rodriguez. 2012. Ovarian cancer: Etiology, risk factors and epidemiology. Clin. Obstet. Gynecol. 55:3–23. doi:10.1097/GRF.0b013e31824b4611.
  • International Agency for Research on Cancer (IARC). 1991. IARC monographs on the evaluation of carcinogenic risks to humans volume 51: Coffee, tea, mate, methylxanthines and methylglyoxal, IARC Monograph No. 51, 523. Geneva, Switzerland: World Health Organization (WHO).
  • International Agency for Research on Cancer (IARC). 2010. IARC monographs on the evaluation of carcinogenic risks to humans volume 93: Carbon black, titanium dioxide, and talc, 466. Lyon, France: International Agency for Research on Cancer (IARC); World Health Organization (WHO). IARC Monograph No. 93. http://monographs.iarc.fr/ENG/Monographs/vol100C/mono93.pdf.
  • International Agency for Research on Cancer (IARC). 2018. IARC monographs on the evaluation of carcinogenic risks to humans volume 116: Drinking coffee, tea, mate, and very hot beverages. Lyon, France: International Agency for Research on Cancer (IARC) World Health Organization (WHO), Geneva, Switzerland. IARC Monograph No. 116, 508.
  • Jelovac, D., and D. K. Armstrong. 2011. Recent progress in the diagnosis and treatment of ovarian cancer. CA Cancer J. Clin. 61:183–203. doi:10.3322/caac.20113.
  • Jordan, S. J., A. C. Green, D. C. Whiteman, and P. M. Webb. 2007. Risk factors for benign serous and mucinous epithelial ovarian tumors. Obstet. Gynecol. 106:647–54. doi:10.1097/01.AOG.0000254159.75977.fa.
  • Jurek, A. M., S. Greenland, G. Maldonado, and T. R. Church. 2005. Proper interpretation of non-differential misclassification effects: Expectations vs observations. Int. J. Epidemiol. 34:680–87. doi:10.1093/ije/dyi060.
  • Jurek, A. M., G. Maldonado, S. Greenland, and T. R. Church. 2006. Exposure-measurement error is frequently ignored when interpreting epidemiologic study results. Eur. J. Epidemiol. 21:871–76. doi:10.1007/s10654-006-9083-0.
  • Keskin, N., Y. A. Teksen, E. G. Ongun, Y. Ozay, and H. Saygili. 2009. Does long-term talc exposure have a carcinogenic effect on the female genital system of rats? An experimental pilot study. Arch. Gynecol. Obstet. 280:925–31. doi:10.1007/s00404-009-1030-3.
  • Kunz, G., D. Beil, H. Deininger, L. Wildt, and G. Leyendecker. 1996. The dynamics of rapid sperm transport through the female genital tract: Evidence from vaginal sonography of uterine peristalsis and hysterosalpingoscintigraphy. Human Reprod. 11:627–32. doi:10.1093/HUMREP/11.3.627.
  • Kurta, M., K. B. Moysich, J. L. Weissfeld, A. O. Youk, C. H. Bunker, R. P. Edwards, F. Modugno, R. B. Ness, and B. Diergaarde. 2012. Use of fertility drugs and risk of ovarian cancer: Results from a U.S.-based case-control study. Cancer Epidemiol. Biomarkers Prev. 21 (8):1282–92. doi:10.1158/1055-9965.EPI-12-0426.
  • La Vecchia, C. 2017. Ovarian cancer: Epidemiology and risk factors. Eur. J. Cancer Prev. 26:55–62. doi:10.1097/CEJ.0000000000000217.
  • Langseth, H., S. E. Hankinson, J. Siemiatycki, and E. Weiderpass. 2008. Perineal use of talc and risk of ovarian cancer. J. Epidemiol. Community Health 62:358–60. doi:10.1136/jech.2006.047894.
  • Langseth, H., and K. Kjaerheim. 2004. Ovarian cancer and occupational exposure among pulp and paper employees in Norway. Scand. J. Work Environ. Health 30:256–361. doi:10.5271/sjweh.823.
  • Lash, T. L., M. P. Fox, and A. K. Fink. 2009. Applying quantitative bias analysis to epidemiologic data. New York, NY: Springer.
  • Lash, T. L., M. P. Fox, R. F. MacLehose, G. Maldonado, L. C. McCandless, and S. Greenland. 2014. Good practices for quantitative bias analysis. Int. J. Epidemiol. 43:1969–85. doi:10.1093/ije/dyu149.
  • Lemen, R. A. 2016. Mesothelioma from asbestos exposures: Epidemilogic patters and impact in the United States. J. Toxicol Environ. Health B 19:250–65. doi:10.1080/10937404.2016.1195323.
  • Lukanova, A., and R. Kaaks. 2005. Endogenous hormones and ovarian cancer: Epidemiology and current hypotheses. Cancer Epidemiol. Biomarkers Prev. 14:98–107.
  • Mandarino, A., D. J. Gregory, C. C. McGuire, B. W. Leblanc, H. Witt, L. M. Rivera, J. J. Godleski, and A. V. Fedulov. 2020. The effect of talc particles on phagocytes in co-culture with ovarian cancer cells. Environ. Res. 180:108676. doi:10.1016/j.envres.2019.108676.
  • Mayo Clinic. 2019. Ovarian cancer: Symptoms & causes. July 25. https://www.mayoclinic.org/diseases-conditions/ovarian-cancer/symptoms-causes/syc-20375941.
  • McDonald, S. A., Y. Fan, W. R. Welch, D. W. Cramer, and J. J. Godleski. 2019b. Migration of talc from the perineum to multiple pelvic organ sites. Am. J. Clin. Pathol. 152:590–607. doi:10.1093/ajcp/aqz080.
  • McDonald, S. A., Y. Fan, W. R. Welch, D. W. Cramer, R. C. Stearns, L. Sheedy, M. Katler, and J. J. Godleski. 2019a. Correlative polarizing light and scanning electron microscopy for the assessment of talc in pelvic region lymph nodes. Ultrastruct. Pathol. 43:13–27. doi:10.1080/01913123.2019.1593271.
  • Memorial Sloan Kettering Cancer Center. 2019. Ovarian cancer. https://www.mskcc.org/cancer-care/types/ovarian.
  • Merritt, M. A., A. C. Green, C. M. Nagle, and P. M. Webb; Australian Cancer Study (Ovarian Cancer); Australian Ovarian Cancer Study Group. 2008. Talcum powder, chronic pelvic inflammation and NSAIDs in relation to risk of epithelial ovarian cancer. Int. J. Cancer 122:170–76. doi:10.1002/ijc.23017.
  • Mills, P. K., D. G. Riordan, R. D. Cress, and H. A. Young. 2004. Perineal talc exposure and epithelial ovarian cancer risk in the Central Valley of California. Int. J. Cancer 112:458–64. doi:10.1002/ijc.20434.
  • Moorman, P. G., R. T. Palmieri, L. Akushevich, A. Berchuck, and J. M. Schildkraut. 2009. Ovarian cancer risk factors in African-American and white women. Am. J. Epidemiol. 170:598–606. doi:10.1093/aje/kwp176.
  • Mostafa, S. A., C. B. Bargeron, R. W. Flower, N. B. Rosenshein, T. H. Parmley, and J. D. Woodruff. 1985. Foreign body granulomas in normal ovaries. Obstet. Gynecol. 66:701–02.
  • Murphy, F. A., A. Schinwald, C. A. Poland, and K. Donaldson. 2012. The mechanism of pleural inflammation by long carbon nanotubes: Interaction of long fibres with macrophages stimulates them to amplify pro-inflammatory responses in mesothelial cells. Part. Fibre Toxicol. 9:8. doi:10.1186/1743-8977-9-8.
  • Muscat, J. E., and M. S. Huncharek. 2008. Perineal talc use and ovarian cancer: A critical review. Eur. J. Cancer Prev. 17:139–46. doi:10.1097/CEJ.0b013e32811080ef.
  • Musser, S. M., [US Food and Drug Administration (US FDA)]. 2014. Letter to S. Epstein (University of Illinois, Chicago) [re: Response to Citizen Petitions requesting that the Food and Drug Administration (FDA) require a cancer warning on cosmetic talc products]. 94P-0420, FDA-2008-P-0309-0001/CP, 7p., April 1.
  • National Cancer Institute (NCI). 2016. Ovarian, fallopian tube, and primary peritoneal cancer prevention (PDQ) - Professional version. February 4. http://www.cancer.gov/types/ovarian/hp/ovarian-prevention-pdq.
  • National Institute for Occupational Safety and Health (NIOSH). 2011. Asbestos fibers and other elongate mineral particles: State of the science and roadmap for research (Revised Edition). DHHS (NIOSH) Publication No. 2011-159, NIOSH Current Intelligence Bulletin 62, 174p., April. Accessed July 30, 2018 https://www.cdc.gov/niosh/docs/2011-159/pdfs/2011-159.pdf?id=10.26616/NIOSHPUB2011159.
  • National Toxicology Program (NTP). 1993. Toxicology and carcinogenesis studies of talc (CAS NO. 14807-96-6) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP Technical Report Series No. 421, NIH Publication No. 93-3152, 287p., September.
  • Ness, R. B., and C. Cottreau. 1999. Possible role of ovarian epithelial inflammation in ovarian cancer. J. Natl. Cancer Inst. 91:1459–67. doi:10.1093/jnci/91.17.1459.
  • Ness, R. B., J. A. Grisso, C. Cottreau, J. Klapper, R. Vergona, J. E. Wheeler, M. Morgan, and J. J. Schlesselman. 2000. Factors related to inflammation of the ovarian epithelium and risk of ovarian cancer. Epidemiology 11:111–17. doi:10.1097/00001648-200003000-00006.
  • O’Brien, K. M., S. S. Tworoger, H. R. Harris, G. L. Anderson, C. R. Weinberg, B. Trabert, A. M. Kaunitz, A. A. D’Aloisio, D. P. Sandler, and N. Wentzensen. 2020. Association of powder use in the genital area with risk of ovarian cancer. J Am Med Assoc 323:49–59. doi:10.1001/jama.2019.20079.
  • Oberdorster, G. 1995. The NTP talc inhalation study: A critical appraisal focused on lung particle overload. Regul. Toxicol. Pharmacol. 21:233–41. doi:10.1006/rtph.1995.1034.
  • Ozesmi, M., T. E. Patiroglu, G. Hillerdal, and C. Ozesmi. 1985. Peritoneal mesothelioma and malignant lymphoma in mice caused by fibrous zeolite. Br. J. Ind. Med. 42:746–49. doi:10.1136/oem.42.11.746.
  • Penninkilampi, R., and G. D. Eslick. 2018. Perineal talc use and ovarian cancer: A systematic review and meta-analysis. Epidemiology 29:41–49. doi:10.1097/EDE.0000000000000745.
  • Phillips, J. C., P. J. Young, K. Hardy, and S. D. Gangolli. 1978. Studies on the absorption and disposition of 3H-labelled talc in the rat, mouse, guinea-pig and rabbit. Food Cosmet. Toxicol. 16:161–63. doi:10.1016/S0015-6264(78)80197-7.
  • Pott, F., F. Huth, and K. H. Friedrichs. 1974. Tumorigenic effect of fibrous dusts in experimental animals. Environ. Health Perspect. 9:313–15. doi:10.1289/ehp.749313.
  • Purdie, D., A. Green, C. Bain, V. Siskind, B. Ward, N. Hacker, M. Quinn, G. Wright, P. Russell, and B. Susil. 1995. Reproductive and other factors and risk of epithelial ovarian cancer: An Australian case-control study. Survey of women’s health study group. Int. J. Cancer 62:676–84. doi:10.1002/ijc.2910620606.
  • Purdie, D. M., C. J. Bain, V. Siskind, P. M. Webb, and A. C. Green. 2003. Ovulation and risk of epithelial ovarian cancer. Int. J. Cancer 104:228–32. doi:10.1002/ijc.10927.
  • Rosenblatt, K. A., M. Szklo, and N. B. Rosenshein. 1992. Mineral fiber exposure and the development of ovarian cancer. Gynecol. Oncol. 45:20–25. doi:10.1016/0090-8258(92)90485-2.
  • Rosenblatt, K. A., N. S. Weiss, K. L. Cushing-Haugen, K. G. Wicklund, and M. A. Rossing. 2011. Genital powder exposure and the risk of epithelial ovarian cancer. Cancer Causes Control 22:737–42. doi:10.1007/s10552-011-9746-3.
  • Rosenman, K. D. 2012. Talc. In Patty’s toxicology, ed. E. Bingham, and B. Cohrssen, 257–72. 6th ed. Hoboken, NJ: John Wiley & Sons, Inc..
  • Rothman, K. J., S. Greenland, and T. L. Lash. 2008. Case-control studies. In Modern epidemiology, 111–27. 3rd ed. (Rothman, KJ; Greenland, S; Lash, TL). Philadelphia, PA: Lippincott Williams & Wilkins.
  • Rothman, K. J., H. Pastides, and J. Samet. 2000. Interpretation of epidemiologic studies on talc and ovarian cancer, 11., November 28.
  • Sahu, A. P., R. Shanker, and S. H. Zaidi. 1978. Pulmonary response to kaolin, mica and talc in mice. Exp. Pathol. 16:276–82. doi:10.1016/S0014-4908(78)80031-3.
  • Schildkraut, J. M., S. E. Abbott, A. J. Alberg, E. V. Bandera, J. S. Barnholtz-Sloan, M. L. Bondy, M. L. Cote, E. Funkhouser, L. C. Peres, E. S. Peters, et al. 2016. Association between body powder use and ovarian cancer: The African American cancer epidemiology study (AACES). Canccer Epidemiol. Biomarkers Prev. 25:1411–17. doi:10.1158/1055-9965.EPI-15-1281.
  • Sjosten, A. C., H. Ellis, and G. A. Edelstam. 2004. Retrograde migration of glove powder in the human female genital tract. Human Reprod. 19:991–95. doi:10.1093/humrep/deh156.
  • Stanton, M. F., M. Layard, A. Tegeris, E. Miller, M. May, E. Morgan, and A. Smith. 1981. Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals. J. Natl. Cancer Inst. 67:965–75.
  • Stenback, F., and J. Rowland. 1978. Role of talc and benzo(a)pyrene in respiratory tumor formation. An experimental study. Scand. J. Respir. Dis. 59:130–40.
  • Sueblinvong, T., and M. E. Carney. 2009. Current understanding of risk factors for ovarian cancer. Curr. Treat. Options Oncol. 10:68–87. doi:10.1007/s11864-009-0108-2.
  • Taher, M. K., N. Farhat, N. A. Karyakina, N. Shilnikova, S. Ramoju, C. A. Gravel, K. Krishnan, D. Mattison, S. W. Wen, and D. Krewski. 2019. Critical review of the association between perineal use of talc powder and risk of ovarian cancer. Reprod. Toxicol. 90:88–101. doi:10.1016/j.reprotox.2019.08.015.
  • Terry, K. L., S. Karageorgi, Y. B. Shvetsov, M. A. Merritt, G. Lurie, P. J. Thompson, M. E. Carney, R. P. Weber, L. Akushevich, W. H. Lo-Ciganic, et al. 2013. Genital powder use and risk of ovarian cancer: A pooled analysis of 8,525 cases and 9,859 controls. Cancer Prev. Res. 6:811–21. doi:10.1158/1940-6207.CAPR-13-0037.
  • Tzonou, A., A. Polychronopoulou, C. C. Hsieh, A. Rebelakos, A. Karakatsani, and D. Trichopoulos. 1993. Hair dyes, analgesics, tranquilizers and perineal talc application as risk factors for ovarian cancer. Int. J. Cancer 55:408–10. doi:10.1002/ijc.2910550313.
  • Urban, N., S. Hawley, H. Janes, B. Y. Karlan, C. D. Berg, C. W. Drescher, J. E. Manson, M. R. Palomares, M. B. Daly, J. Wactawski-Wende, et al. 2015. Identifying post-menopausal women at elevated risk for epithelial ovarian cancer. Gynecol. Oncol. 139:253–60. doi:10.1016/j.ygyno.2015.08.024.
  • Venter, P. F., and M. Iturralde. 1979. Migration of a particulate radioactive tracer from the vagina to the peritoneal cavity and ovaries. S. Afr. Med. J. 55:917–99.
  • Vrijheid, M., E. Cardis, B. K. Armstrong, A. Auvinen, G. Berg, K. G. Blaasaas, J. Brown, M. Carroll, A. Chetrit, H. C. Christensen, et al. 2006. Validation of short term recall of mobile phone use for the Interphone study. Occup. Environ. Med. 63:237–43. doi:10.1136/oem.2004.019281.
  • Wagner, J. C., G. Berry, T. J. Cooke, R. J. Hill, F. D. Pooley, and J. W. Skidmore. 1977. Animal experiments with talc. Inhaled Part 4 (pt. 2):647–54. In Inhaled Particles. IV. Proceedings of an International Symposium Organized by the British Occupational Hygiene Society, held September 22-26. (Eds.: Walton, WH; McGovern, B), Pergamon Press.
  • Walsh, T., S. Casadei, M. K. Lee, C. C. Pennil, A. S. Nord, A. M. Thornton, W. Roeb, K. J. Agnew, S. M. Stray, A. Wickramanayake, et al. 2011. Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing. Proc. Natl. Acad. Sci. USA. 108:10832–37. doi:10.1073/pnas.1115052108.
  • Wehner, A. P. 2002. Cosmetic talc should not be listed as a carcinogen: Comments on NTP’s deliberations to list talc as a carcinogen. Regul. Toxicol. Pharmacol. 36:40–50. doi:10.1006/rtph.2002.1560.
  • Wehner, A. P., A. S. Hall, R. E. Weller, E. A. Lepel, and R. E. Schirmer. 1985. Do particles translocate from the vagina to the oviducts and beyond? Food Chem. Toxicol. 23:367–72. doi:10.1016/0278-6915(85)90073-0.
  • Wehner, A. P., R. E. Weller, and E. A. Lepel. 1986. On talc translocation from the vagina to the oviducts and beyond. Food Chem. Toxicol. 24:329–38. doi:10.1016/0278-6915(86)90011-6.
  • Wehner, A. P., G. M. Zwicker, and W. C. Cannon. 1977. Inhalation of talc baby powder by hamsters. Food Cosmet. Toxicol. 15:121–29. doi:10.1016/S0015-6264(77)80317-9.
  • Wentzensen, N., and S. Wacholder. 2014. Talc use and ovarian cancer: Epidemiology between a rock and a hard place. J. Natl. Cancer Inst. 106 (dju260). doi: 10.1093/jnci/dju260.
  • Whittemore, A. S., M. L. Wu, R. S. Paffenbarger Jr, D. L. Sarles, J. B. Kampert, S. Grosser, D. L. Jung, S. Ballon, and M. Hendrickson. 1988. Personal and environmental characteristics related to epithelial ovarian cancer. II. Exposures to talcum powder, tobacco, alcohol, and coffee. Am. J. Epidemiol. 128:1228–40. doi:10.1093/oxfordjournals.aje.a115077.
  • Williams, K. A., S. I. Labidi-Galy, K. L. Terry, A. F. Vitonis, W. R. Welch, A. Goodman, and D. W. Cramer. 2014. Prognostic significance and predictors of the neutrophil-to-lymphocyte ratio in ovarian cancer. Gynecol. Oncol. 132:542–50. doi:10.1016/j.ygyno.2014.01.026.
  • Wong, C., R. E. Hempling, M. S. Piver, N. Natarajan, and C. J. Mettlin. 1999. Perineal talc exposure and subsequent epithelial ovarian cancer: A case-control study. Obstet. Gynecol. 93:372–76. doi:10.1016/s0029-7844(98)00439-6.
  • Wu, A. H., C. L. Pearce, C. C. Tseng, and M. C. Pike. 2015. African Americans and Hispanics remain at lower risk of ovarian cancer than non-Hispanic whites after considering nongenetic risk factors and oophorectomy rates. Cancer Epidemiol. Biomarkers Prev. 24:1094–100. doi:10.1158/1055-9965.EPI-15-0023.
  • Wu, A. H., C. L. Pearce, C. C. Tseng, C. Templeman, and M. C. Pike. 2009. Markers of inflammation and risk of ovarian cancer in Los Angeles County. Int. J. Cancer 124:1409–15. doi:10.1002/ijc.24091.