References
- Abdo, J. M., N. A. Sopko, and S. M. Milner. 2020. The applied anatomy of human skin: A model for regeneration. Wound Med 28:100179. doi:https://doi.org/10.1016/j.wndm.2020.100179.
- Abolhasani, R., F. Araghi, M. Tabary, A. Aryannejad, B. Mashinchi, and R. M. Robati. 2021. The impact of air pollution on skin and related disorders: A comprehensive review. Dermatol. Ther 34. doi:https://doi.org/10.1111/dth.14840.
- Achanta, S., N. R. Chintagari, M. Brackmann, S. Balakrishna, and S.-E. Jordt. 2018. TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation. Toxicol. Lett 293:140–48. doi:https://doi.org/10.1016/j.toxlet.2018.03.007.
- Agache, P., and D. Varchon. 2017. Skin mechanical function in Agache’s measuring the skin Agache's Measuring the Skin: Non-invasive Investigations, Physiology, Normal Constants second edition . In P. Humbert, H. Maibach, F. Fanian, and P. Agache. ed., 945–992. Switzerland: Springer. doi:https://doi.org/10.1007/978-3-319-32383-1_129.
- Ahmad, N., and H. Mukhtar. 2004. Cytochrome P450: A target for drug development for skin diseases. J. Invest. Dermatol 123 (3):417–25. doi:https://doi.org/10.1111/j.0022-202X.2004.23307.x.
- Akdis, M., A. Aab, C. Altunbulakli, K. Azkur, R. A. Costa, R. Crameri, S. Duan, T. Eiwegger, A. Eljaszewicz, R. Ferstl, et al. 2016. Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases. J. Allergy Clin. Immunol 138 (4):984–1010. doi:https://doi.org/10.1016/j.jaci.2016.06.033.
- Akintobi, A. M., C. M. Villano, and L. A. White. 2007. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure of normal human dermal fibroblasts results in AhR-dependent and -independent changes in gene expression. Toxicol. Appl. Pharmacol 220 (1):9–17. doi:https://doi.org/10.1016/j.taap.2006.12.002.
- Akira, S., T. Hirano, T. Taga, and K. Tadamitsu. 1990. Biology of multifunctional cytokines: IL-6 and related molecules (IL-1 and TNF). FASEB J 4. doi:https://doi.org/10.1096/fasebj.4.11.2199284.
- Albanesi, C., C. Scarponi, M. L. Giustizieri, and G. Girolomoni. 2005. Keratinocytes in inflammatory skin diseases. Curr. Drug Targets Inflamm. Allergy 4 (3):329–34. doi:https://doi.org/10.2174/1568010054022033.
- Alfirevic, A., and M. Pirmohamed. 2011. Drug induced hypersensitivity and the HLA complex. Pharmaceuticals 4 (1):69–90. doi:https://doi.org/10.3390/ph4010069.
- Ali-Osman, F., O. Akande, G. Antoun, J. X. Mao, and J. Buolamwini. 1997. Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione s-transferase pi gene variants: Evidence for differential catalytic activity of the encoded proteins. J. Biol. Chem 272 (15):10004–12. doi:https://doi.org/10.1074/jbc.272.15.10004.
- Allam, M., and H. Riad. 2013. Concise review of recent studies in vitiligo. Qatar Med. J 2013 (2):1–19. doi:https://doi.org/10.5339/qmj.2013.10.
- Allen, M. H., S. H. Wakelin, D. Holloway, S. Lisby, O. Baadsgaard, J. N. W. N. Barker, and J. P. McFadden. 2000. Association of TNFa gene polymorphism at position −308 with susceptibility to irritant contact dermatitis. Immunogenetics 51 (3):201–05. doi:https://doi.org/10.1007/s002510050032.
- Almohideb, M. 2020. Associations of angiotensin-converting enzyme gene insertion/deletion (ACE gene I/D) polymorphism with vitiligo: An updated systematic review and meta-analysis. Cureus 12 (5):e8046. doi:https://doi.org/10.7759/cureus.8046.
- Altman, J., H. O. Perry, and H. O. Perry. 1961. The variations and course of lichen planus. Arch. Dermatol 84 (2):179–91. doi:https://doi.org/10.1001/archderm.1961.01580140005001.
- Aly, D. G., and R. S. Shahin. 2010. Oxidative stress in lichen planus. Acta Dermatovenerol. Alp. Pannonica Adriat 19:3–11.
- Amin, M. N., K. F. Liza, S. Sarwar, J. Ahmed, M. T. Adnan, M. I. Chowdhury, M. Z. Hossain, and M. S. Islam. 2015. Effect of lipid peroxidation, antioxidants, macro minerals and trace elements on eczema. Arch. Dermatol. Res 307 (7):617–23. doi:https://doi.org/10.1007/s00403-015-1570-2.
- Amir Aslani, B., and S. Ghobadi. 2016. Studies on oxidants and antioxidants with a brief glance at their relevance to the immune system. Life Sci 146:163–73. doi:https://doi.org/10.1016/j.lfs.2016.01.014.
- Anderson, S. E., and B. J. Meade. 2014. Potential health effects associated with dermal exposure to occupational chemicals. Environ. Health Insights 8 (Suppl1):51–62. doi:https://doi.org/10.4137/EHI.S15258.
- Ando, T., W. Xiao, P. Gao, S. Namiranian, K. Matsumoto, Y. Tomimori, H. Hong, H. Yamashita, M. Kimura, J. Kashiwakura, et al. 2014. Critical role for mast cell STAT5 activity in skin inflammation. Cell Rep 6 (2):366–76. doi:https://doi.org/10.1016/j.celrep.2013.12.029.
- Anlar, H. G., M. Bacanli, S. İritaş, C. Bal, T. Kurt, E. Tutkun, O. H. Yilmaz, and N. Basaran. 2017. Effects of occupational silica exposure on oxidative stress and immune system parameters in ceramic workers in Turkey. J. Toxicol. Environ. Health A 70 (13–15):688–96. doi:https://doi.org/10.1080/15287394.2017.1286923.
- Arimitsu, J., T. Hirano, S. Higa, M. Kawai, T. Naka, A. Ogata, Y. Shima, M. Fujimoto, T. Yamadori, K. Hagiwara, et al. 2006. IL-18 gene polymorphisms affect IL-18 production capability by monocytes. Biochem. Biophys. Res. Commun 342 (4):1413–16. doi:https://doi.org/10.1016/j.bbrc.2006.02.096.
- Asadi, S., K.-D. Alysandratos, A. Angelidou, A. Miniati, N. Sismanopoulos, M. Vasiadi, B. Zhang, D. Kalogeromitros, and T. C. Theoharides. 2012. Substance P (SP) induces expression of functional corticotropin-releasing hormone receptor-1 (CRHR-1) in human mast cells. J. Invest. Dermatol 132 (2):324–29. doi:https://doi.org/10.1038/jid.2011.334.
- Asadullah, K., W. Sterry, and H. D. Volk. 2003. Interleukin-10 therapy - review of a new approach. Pharmacol. Rev 55 (2):241–69. doi:https://doi.org/10.1124/pr.55.2.4.
- Asadullah, K., W. Sterry, K. Stephanek, D. Jasulaitis, M. Leupold, H. Audring, H. D. Volk, and W. D. Döcke. 1998. IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy: A new therapeutic approach. J. Clin. Invest 101 (4):783–94. doi:https://doi.org/10.1172/JCI1476.
- Ayasse, M. T., J. Buddenkotte, M. Alam, and M. Steinhoff. 2020. Role of neuroimmune circuits and pruritus in psoriasis. Exp. Dermatol 29 (4):414–26. doi:https://doi.org/10.1111/exd.14071.
- Baker, B. S., J. M. Ovigne, A. V. Powles, S. Corcoran, and L. Fry. 2003. Normal keratinocytes express toll-like receptors (TLRs) 1, 2 and 5: Modulation of TLR expression in chronic plaque psoriasis. Br. J. Dermatol 148 (4):670–79. doi:https://doi.org/10.1046/j.1365-2133.2003.05287.x.
- Ballerini, S., L. Bellincampi, S. Bernardini, R. Iori, C. Cortese, and G. Federici. 2003. Analysis of GSTP1-1 polymorphism using real-time polymerase chain reaction. Clin. Chim. Acta 329 (1–2):127–32. doi:https://doi.org/10.1016/S0009-8981(02)00422-9.
- Baran, W., J. C. Szepietowski, G. Mazur, and E. Baran. 2008. IL-6 and IL-10 promoter gene polymorphisms in psoriasis vulgaris. Acta DermVenereol. 88:113–16. doi:https://doi.org/10.2340/00015555-0427.
- Baron, J. M., D. Ho, R. Schiffer, S. Frankenberg, M. Neis, H. F. Merk, and F. K. Jugert. 2001. Expression of multiple P450 and multidrug resistance-associated transporter proteins in human skin keratinocytes. J. Invest. Dermatol 116 (4):541–48. doi:https://doi.org/10.1046/j.1523-1747.2001.01298.x.
- Basher, N. S., A. Malik, F. Aldakheel, A. A. Chaudhary, H. A. Rudayni, M. Alkholief, and A. Alshamsan. 2021. Deleterious effect of angiotensin-converting enzyme gene polymorphism in vitiligo patients. Saudi J. Biol. Sci 28 (8):4478–83. doi:https://doi.org/10.1016/j.sjbs.2021.04.045.
- Basketter, D., R. Darlenski, and J. W. Fluhr. 2008. Skin irritation and sensitization: Mechanisms and new approaches for risk assessment. 2. Skin sensitization. Skin Pharmacol. Physiol 21 (4):191–202. doi:https://doi.org/10.1159/000135635.
- Baudin, B. 2002. New aspects on angiotensin-converting enzyme: From gene to disease. Clin. Chem. Lab. Med 40 (3):256–65. doi:https://doi.org/10.1515/CCLM.2002.042.
- Baurecht, H., M. Hotze, S. Brand, C. Büning, P. Cormican, A. Corvin, D. Ellinghaus, A. D. irvine, A. D. irvine, A. D. Irvine, et al. 2015. Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms. Am. J. Human Genet 97 (6):933. doi:https://doi.org/10.1016/j.ajhg.2015.10.018.
- Belyaeva, T., I. Ponomarenko, E. Reshetnikov, A. Polonikov, I. Aristova, A. Elykova, N. Rudykh, and M. Churnosov. 2020. Dataset of allele, genotype and haplotype frequencies of four polymorphisms filaggrin gene in Russian patients with atopic dermatitis. Data Brief 29:105307. doi:https://doi.org/10.1016/j.dib.2020.105307.
- Benhadou, F., D. Mintoff, and V. Del Marmol. 2019. Psoriasis: Keratinocytes or immune cells - which is the trigger? Dermatology 235 (2):91–100. doi:https://doi.org/10.1159/000495291.
- Bergström, M. A., H. Ott, A. Carlsson, M. Neis, G. Zwadlo-Klarwasser, C. A. M. Jonsson, H. F. Merk, A. T. Karlberg, and J. M. Baron. 2007a. A skin-like cytochrome P450 cocktail activates prohaptens to contact allergenic metabolites. J. Invest. Dermatol 5 (5):1145–53. doi:https://doi.org/10.1038/sj.jid.5700638.
- Berhane, K., M. Widersten, Å. Engström, J. W. Kozarich, and B. Mannervik. 1994. Detoxication of base propenals and other α,β-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases. Proc. Natl. Acad. Sci. U.S.A 91:1480–84. doi:https://doi.org/10.1073/pnas.91.4.1480.
- Bertino, L., F. Guarneri, S. P. Cannavò, M. Casciaro, G. Pioggia, and S. Gangemi. 2020. Oxidative stress and atopic dermatitis. Antioxidants 9 (3):196. doi:https://doi.org/10.3390/antiox9030196.
- Bettelli, E., Y. Carrier, W. Gao, T. Korn, T. B. Strom, M. Oukka, H. L. Weiner, and V. K. Kuchroo. 2006. Reciprocal developmental pathways for the generation of pathogenic effector Th17 and regulatory T cells. Nature 441 (7090):235–38. doi:https://doi.org/10.1038/nature04753.
- Bielecki, P., S. J. Riesenfeld, J.-C. Hütter, E. T. Triglia, M. S. Kowalczyk, R. R. Ricardo-Gonzalez, M. Lian, M. C. A. Vesely, L. Kroehling, H. Xu, et al. 2021. Skin-resident innate lymphoid cells converge on a pathogenic effector state. Nature 592 (7852):128–32. doi:https://doi.org/10.1038/s41586-021-03188-w.
- Bilsborough, J., D. Y. M. Leung, M. Maurer, M. Howell, M. Boguniewcz, L. Yao, H. Storey, C. LeCiel, B. Harder, and J. A. Gross. 2006. IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. J. Allergy Clin. Immunol 117 (2):418–25. doi: https://doi.org/10.1016/j.jaci.2005.10.046.
- Biswas, S. K. 2016. Does the interdependence between oxidative stress and inflammation explain the antioxidant paradox? Oxid. Med. Cell Longev 2016:1–9. doi:https://doi.org/10.1155/2016/5698931.
- Black, A. P. B., M. R. Ardern-Jones, V. Kasprowicz, P. Bowness, L. Jones, A. S. Bailey, and G. S. Ogg. 2007. Human keratinocyte induction of rapid effector function in antigen-specific memory CD4+ and CD8+ T cells. Eur. J. Immunol 37 (6):1485–93. doi:https://doi.org/10.1002/eji.200636915.
- Blake, K. J., X. R. Jiang, and I. M. Chiu. 2019. Neuronal regulation of immunity in the skin and lungs. Trends Neurosci 42 (8):537–51. doi:https://doi.org/10.1016/j.tins.2019.05.005.
- Blömeke, B., R. Brans, H. Dickel, T. Bruckner, S. Erdmann, M. Heesen, H. F. Merk, and P. J. Coenraads. 2009. Association between TNFA-308 G/A polymorphism and sensitization to para- phenylenediamine: A case-control study. Allergy 64 (2):279–83. doi:https://doi.org/10.1111/j.1398-9995.2008.01704.x.
- Board, P. G., R. T. Baker, G. Chelvanayagam, and L. S. Jermiin. 1997. Zeta, a novel class of glutathione transferases in a range of species from plants to humans. Biochem. J 328 (3):929–35. doi:https://doi.org/10.1042/bj3280929.
- Bock, K. W. 2019. Aryl Hydrocarbon Receptor (AHR): From selected human target genes and crosstalk with transcription factors to multiple AHR functions. Biochem. Pharmacol 168:65–70. doi:https://doi.org/10.1016/j.bcp.2019.06.015.
- Boguniewicz, M., and D. Y. M. Leung. 2011. Atopic dermatitis: A disease of altered skin barrier and immune dysregulation. Immunol. Rev 242 (1):233–46. doi:https://doi.org/10.1111/j.1600-065X.2011.01027.x.
- Böhme, M., C. Söderhäll, I. Kull, A. Bergström, M. V. Hage, and C. F. Wahlgren. 2012. Filaggrin mutations increase the risk for persistent dry skin and eczema independent of sensitization. J. Allergy Clin. Immunol 129 (4):1153–55. doi:https://doi.org/10.1016/j.jaci.2011.11.032.
- Borici-Mazi, R., S. Kouridakis, and K. Kontou-Fili. 1999. Cutaneous responses to substance P and calcitonin gene-related peptide in chronic urticaria: The effect of cetirizine and dimethindene. Allergy 54 (1):46–56. doi:https://doi.org/10.1034/j.1398-9995.1999.00726.x.
- Bovenzi, M., F. Barbone, F. E. Pisa, A. Betta, and L. Romeo. 2001. Scleroderma and occupational exposure to hand-transmitted vibration. Int. Arch. Occup. Environ. Health 74 (8):579–82. doi:https://doi.org/10.1007/s004200100262.
- Boyman, O., T. Werfel, and C. A. Akdis. 2012. The suppressive role of IL-10 in contact and atopic dermatitis. J. Allergy Clin. Immunol 129 (1):160–61. doi:https://doi.org/10.1016/j.jaci.2011.10.046.
- Broccardo, C. J., S. Mahaffey, J. Schwarz, L. Wruck, G. David, P. M. Schlievert, N. A. Reisdorph, and D. Y. M. Leung. 2011. Comparative proteomic profiling of patients with atopic dermatitis based on history of eczema herpeticum infection and Staphylococcus aureus colonization. J. Allergy Clin. Immunol 127 (1):186–93. doi:https://doi.org/10.1016/j.jaci.2010.10.033.
- Burian, M., and A. S. Yazdi. 2018. NLRP1 is the key inflammasome in primary human keratinocytes. J. Invest. Dermatol 138 (12):2507. doi:https://doi.org/10.1016/j.jid.2018.08.004.
- Caccuri, A. M., G. Antonini, P. G. Board, J. Flanagan, M. W. Parker, R. Paolesse, P. Turella, G. Federici, M. Lo Bello, and G. Ricci. 2001. Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of substrate binding to the active site of glutathione transferases. J. Biol. Chem 276 (8):5427–31. doi:https://doi.org/10.1074/jbc.M002819200.
- Carpenter, D. O. 2011. Health effects of persistent organic pollutants: The challenge for the Pacific Basin and for the world. Rev. Environ. Health 26 (1):61–69. doi:https://doi.org/10.1515/reveh.2011.009.
- Casciola-Rosen, L., and A. Rosen. 1997. Ultraviolet light-induced keratinocyte apoptosis: A potential mechanism for the induction of skin lesions and autoantibody production in LE. Lupus 6 (2):175–80. doi:https://doi.org/10.1177/096120339700600213.
- Cat, A. N. D., A. C. Montezano, D. Burger, and R. M. Touyz. 2012. Angiotensin II, NADPH oxidase, and redox signaling in the vasculature. Antioxid. Redox Signal 19 (10):1110–20. doi:https://doi.org/10.1089/ars.2012.4641.
- Cevikbas, F., X. Wang, T. Akiyama, C. Kempkes, T. Savinko, A. Antal, G. Kukova, T. Buhl, A. Ikoma, J. Buddenkotte, et al. 2014. A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1. J. Allergy Clin. Immunol 133 (2):448–460.e7. doi:https://doi.org/10.1016/j.jaci.2013.10.048.
- Cheung, P. F. Y., C. K. Wong, A. W. Y. Ho, S. Hu, D. P. Chen, and C. W. K. Lam. 2010. Activation of human eosinophils and epidermal keratinocytes by Th2 cytokine IL-31: Implication for the immunopathogenesis of atopic dermatitis. Int. Immunol 22 (6):453–67. doi:https://doi.org/10.1093/intimm/dxq027.
- Chiarella, P. 2019. Vitiligo susceptibility at workplace and in daily life: The contribution of oxidative stress gene polymorphisms. BMC 3:1–12. doi:https://doi.org/10.1186/s41702-019-0043-1.
- Cho, S. G., Y. H. Lee, H. S. Park, K. Ryoo, K. W. Kang, J. Park, S. J. Eom, M. J. Kim, T. S. Chang, S. Y. Choi, et al. 2001. Glutathione S-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1. J. Biol. Chem 276 (16):12749–55. doi:https://doi.org/10.1074/jbc.M005561200.
- Choa, R., J. Tohyama, S. Wada, H. Meng, J. Hu, M. Okumura, R. M. May, T. F. Robertson, R.-A. L. Pai, A. Nace, et al. 2021. Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion. Science 373 (6554):eabd2893. doi:https://doi.org/10.1126/science.abd2893.
- Christos, Z., and Q. Ju. 2013. Skin effects of dioxins. Biosafety 02 (3):1000112–14. doi:https://doi.org/10.4172/2167-0331.1000113.
- Chun, K. H., Y. Imai, N. Higashi, and T. Irimura. 2000. Involvement of cytokines in the skin-to-lymph node trafficking of cells of the monocyte-macrophage lineage expressing a c-type lectin. Int. Immunol 12 (12):1695–703. doi:https://doi.org/10.1093/intimm/12.12.1695.
- Chung, J., S.-Y. Oh, and Y. K. Shin. 2009. Association of glutathione-s-transferase polymorphisms with atopic dermatitis risk in preschool age children. Clin. Chem. Lab. Med 47 (12):1475–81. doi:https://doi.org/10.1515/CCLM.2009.336.
- Cilingir, O., I. Bulur, B. D. Aras, O. Kutlay, E. Erzurumluoglu, K. Haziyeva, Z. N. Saracoglu, H. K. Erdoğan, K. S. Dincer, H. Gursoy, et al. 2018. The relationship between glutathione-s-transferases polymorphisms and lichen planus susceptibility. Int J Med Res Health Sci 3:2456–6373.
- Clayton, K., A. F. Vallejo, J. Davies, S. Sirvent, and M. E. Polak. 2017. Langerhans cells –Programmed by the epidermis. Front Immunol 8:1–14. doi:https://doi.org/10.3389/fimmu.2017.01676.
- Companjen, A., L. Van Der Wel, L. Van Der Fits, J. Laman, and E. Prens. 2004. Elevated interleukin-18 protein expression in early active and progressive plaque-type psoriatic lesions. Eur. Cytokine Netw 15 (3):210–16.
- Cork, M. J., D. A. Robinson, Y. Vasilopoulos, A. Ferguson, M. Moustafa, A. MacGowan, G. W. Duff, S. J. Ward, and R. Tazi-Ahnini. 2006. New perspectives on epidermal barrier dysfunction in atopic dermatitis: Gene-environment interactions. J. Allergy Clin. Immunol 118 (1):3–21. doi:https://doi.org/10.1016/j.jaci.2006.04.042.
- Cornelissen, C., R. Brans, K. Czaja, C. Skazik, Y. Marquardt, G. Zwadlo-Klarwasser, A. Kim, D. R. Bickers, J. Lüscher‐Firzlaff, B. Lüscher, et al. 2011. Ultraviolet B radiation and reactive oxygen species modulate interleukin-31 expression in T lymphocytes, monocytes and dendritic cells. Br. J. Dermatol 165 (5):966–75. doi:https://doi.org/10.1111/j.1365-2133.2011.10487.x.
- Cornelissen, C., Y. Marquardt, K. Czaja, J. Wenzel, J. Frank, J. Lüscher-Firzlaff, B. Lüscher, and J. M. Baron. 2012. IL-31 regulates differentiation and filaggrin expression in human organotypic skin models. J. Allergy Clin. Immunol 129. doi:https://doi.org/10.1016/j.jaci.2011.10.042.
- Corsini, E., and E. L. Roggen. 2017. Overview of in vitro assessment of immunotoxicity. Curr. Opin. Toxicol 5:13–18. doi:https://doi.org/10.1016/j.cotox.2017.06.016.
- Corsini, E., and I. Kimber. 2007. Factors governing susceptibility to chemical allergy. Toxicol. Lett 168 (3):255–59. doi:https://doi.org/10.1016/j.toxlet.2006.09.015.
- Corsini, E., V. Galbiati, D. Nikitovic, and A. M. Tsatsakis. 2013. Role of oxidative stress in chemical allergens induced skin cells activation. Food. Chem. Toxicol 61:74–81. doi:https://doi.org/10.1016/j.fct.2013.02.038.
- Cosma, G., F. Crofts, E. Taioli, P. Toniolo, and S. Garte. 1993. Relationship between genotype and function of the human CYP1A1 gene. J. Toxicol. Environ. Health 40 (2–3):309–16. doi:https://doi.org/10.1080/15287399309531796.
- Costa, C., E. Miozzi, M. Teodoro, and C. Fenga. 2019. Influence of genetic polymorphism on pesticide-induced oxidative stress. Curr. Opin. Toxicol 13:1–7. doi:https://doi.org/10.1016/j.cotox.2018.12.008.
- Costa, C., G. Briguglio, R. Catanoso, F. Giambò, I. Polito, M. Teodoro, and C. Fenga. 2020. New perspectives on cytokine pathways modulation by pesticide exposure. Curr. Opin. Toxicol 19:99–104. doi:https://doi.org/10.1016/j.cotox.2020.01.002.
- Craven, N. M., C. W. Jackson, B. Kirby, C. Perrey, V. Pravica, I. V. Hutchinson, and C. E. M. Griffiths. 2001. Cytokine gene polymorphisms in psoriasis. Br. J. Dermatol 144 (4):849–53. doi:https://doi.org/10.1046/j.1365-2133.2001.04143.x.
- Cumberbatch, M., and I. Kimber. 1995. Tumor necrosis factor-a is required for accumulation of dendritic cells in draining lymph nodes and for optimal contact sensitization. Immunology 84 (1):31–35.
- Curnow, S. J., D. Scheel-Toellner, W. Jenkinson, K. Raza, O. M. Durrani, J. M. Faint, S. Rauz, K. Wloka, D. Pilling, S. Rose-John, et al. 2004. Inhibition of T cell apoptosis in the aqueous humor of patients with Uve it is by IL-6/soluble il-6 receptor trans – signaling. J. Immunol 173 (8):5290–97. doi:https://doi.org/10.4049/jimmunol.173.8.5290.
- Czarnowicki, T., H. He, A. Leonard, K. Malik, S. Magidi, S. Rangel, K. Patel, K. Ramsey, M. Murphrey, T. Song, et al. 2018. The major orphan forms of ichthyosis are characterized by systemic T-cell activation and Th-17/Tc-17/Th-22/Tc-22 polarization in blood. J. Invest. Dermatol 138 (10):2157–67. doi:https://doi.org/10.1016/j.jid.2018.03.1523.
- Dang, N. N., S. G. Pang, H. Y. Song, L. G. An, and X. L. Ma. 2015. Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an immune response. Braz. J. Med. Biol. Res 48 (1):39–45. doi:https://doi.org/10.1590/1414-431X20144047.
- Deeni, Y. Y., S. H. Ibbotson, J. A. Woods, C. R. Wolf, G. Smith, and G. Novelli. 2013. Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet A (PUVA) sensitivity. PLoS ONE 8 (9):2–8. doi:https://doi.org/10.1371/journal.pone.0075494.
- Del Giudice, M., and S. W. Gangestad. 2018. Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters. Brain, Behav. Immun 70:61–75. doi:https://doi.org/10.1016/j.bbi.2018.02.013.
- Descargues, P., C. Draison, C. Bonnart, M. Kreft, M. Kishibe, A. Ishida-Yamamoto, P. Elias, Y. Barrandon, G. Zambruno, A. Sonnenberg, et al. 2005. Spink5-deficient mice mimic netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity. Nat. Genet 37 (1):56–65. doi:https://doi.org/10.1038/ng1493.
- Dietrich, C. 2016. Antioxidant functions of the aryl hydrocarbon receptor. Stem Cells Int 2016:7943495. doi:https://doi.org/10.1155/2016/7943495.
- Dillon, S. R., C. Sprecher, A. Hammond, J. Bilsborough, M. Rosenfeld-Franklin, S. R. Presnell, H. S. Haugen, M. Maurer, B. Harder, J. Johnston, et al. 2004. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat. Immunol 5 (7):752–60. doi:https://doi.org/10.1038/ni1084.
- Divkovic, M., C. K. Pease, G. F. Gerberick, and D. A. Basketter. 2005. Hapten–protein binding: From theory to practical application in the in vitro prediction of skin sensitization. Contact Dermatitis 53 (4):189–200. doi:https://doi.org/10.1111/j.0105-1873.2005.00683.x.
- Döcke, W.-D., K. Asadullah, G. Belbe, M. Ebeling, C. Höflich, M. Friedrich, W. Sterry, and H.-D. Volk. 2009. Comprehensive biomarker monitoring in cytokine therapy: Heterogeneous, time-dependent, and persisting immune effects of interleukin-10 application in psoriasis. J. Leukoc. Biol 85 (3):582–93. doi:https://doi.org/10.1189/jlb.0408249.
- Doering, T., W. M. Holleran, A. Potratzt, G. Vielhaber, P. M. Elias, K. Suzuki, and K. Sandhoff. 1999. Sphingolipid activator proteins are required for epidermal permeability barrier formation. J. Biol. Chem 274 (16):11038–45. doi:https://doi.org/10.1074/jbc.274.16.11038.
- Eberhard, Y., S. Ortiz, A. R. Lascano, R. Kuznitzky, and H. Marcelo. 2004. Up-regulation of the chemokine CCL21 in the skin of subjects exposed to irritants. BMC Immunol 5 (1):7. doi:https://doi.org/10.1186/1471-2172-5-7.
- Eckhart, L., and E. Tschachler. 2011. Cuts by caspase-14 control the proteolysis of filaggrin. J. Invest. Dermatol 131 (11):2173–75. doi:https://doi.org/10.1038/jid.2011.282.
- Egawa, G., and K. Kabashima. 2018. Barrier dysfunction in the skin allergy. Allergol. Int 67 (1):3–11. doi:https://doi.org/10.1016/j.alit.2017.10.002.
- Eguchi, H., S.-I. Hayashi, J. Watanabe, O. Gotoh, and K. Kawajiri. 1994. Molecular cloning of the human AH receptor gene promoter. Biochem. Biophys. Res. Commun 203 (1):615–22. doi:https://doi.org/10.1006/bbrc.1994.2227.
- Elneam, A. I. A., M. S. Al-Dhubaibi, and A. I. A. A. Alrheam. 2018. Angiotensin-converting enzyme (ACE) D allele as a risk factor for increase serum interleukin-6 and interleukin-8 in psoriasis patients. Maced. J. Med. Sci 6 (5):772–76. doi:https://doi.org/10.3889/oamjms.2018.188.
- Elsabahy, M., and K. L. Wooley. 2013. Cytokines as biomarkers of nanoparticle immunotoxicity. Chem. Soc. Rev 42 (12):5552–76. doi:https://doi.org/10.1039/c3cs60064e.
- Englert, N. A., R. J. Turesky, W. Han, E. E. Bessette, S. D. Spivack, M. Caggana, D. C. Spink, and B. C. Spink. 2012. Genetic and epigenetic regulation of AHR gene expression in MCF-7 breast cancer cells: Role of the proximal promoter GC-rich region. Biochem. Pharmacol 84 (5):722–35. doi:https://doi.org/10.1016/j.bcp.2012.06.013.
- Eskdale, J., D. Kube, H. Tesch, and G. Gallagher. 1997. Mapping of the human IL10 gene and further characterization of the 5´flanking sequence. Immunogenetics 46 (2):120–28. doi:https://doi.org/10.1007/s002510050250.
- Esser, C., I. Bargen, H. Weighardt, T. Haarmann-Stemmann, and J. Krutmann. 2013. Functions of the aryl hydrocarbon receptor in the skin. Semin. Immunopathol 35 (6):677–91. doi:https://doi.org/10.1007/s00281-013-0394-4.
- Esser, C., T. Haarmann-Stemmann, K. Hochrath, T. Schikowski, and J. Krutmann. 2018. AHR and the issue of immunotoxicity. Curr. Opin. Toxicol 10:91–97. doi:https://doi.org/10.1016/j.cotox.2018.03.001.
- Fallon, P. G., T. Sasaki, A. Sandilands, L. E. Campbell, S. P. Saunders, N. E. Mangan, J. J. Callanan, H. Kawasaki, A. Shiohama, A. Kubo, et al. 2009. A homozygous frameshift mutation in the mouse FLG gene facilitates enhanced percutaneous allergen priming. Nat. Genet 41 (5):602–08. doi:https://doi.org/10.1038/ng.358.
- Fan, L., B. W. Busser, T. Q. Lifsted, D. Lo, and T. M. Laufer. 2003. Antigen presentation by keratinocytes directs autoimmune skin disease. Proc Nat Acad Sci USA 100 (6):3386–91. doi:https://doi.org/10.1073/pnas.0437899100.
- Fang, D., and J. Zhu. 2020. Molecular switches for regulating the differentiation of inflammatory and IL-10-producing anti-inflammatory T-helper cells. Cell. Mol. Life Sci 77 (2):289–303. doi:https://doi.org/10.1007/s00018-019-03277-0.
- Fang, Y. Z., S. Yang, and G. Wu. 2002. Free radicals, antioxidants, and nutrition. Nutrition 18 (10):872–79. doi:https://doi.org/10.1016/S0899-9007(02)00916-4.
- Feng, J., P. Yang, M. R. Mack, D. Dryn, J. Luo, X. Gong, S. Liu, L. K. Oetjen, A. V. Zholos, Z. Mei, et al. 2017. Sensory TRP channels contribute differentially to skin inflammation and persistent itch. Nat. Commun 8 (1):980. doi:https://doi.org/10.1038/s41467-017-01056-8.
- Fiorentino, D. F., A. Zlotnik, P. Vieira, T. R. Mosmann, M. Howard, K. W. Moore, and A. O. Garra. 1991. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J. Immunol 6:3444–51.
- Fluhr, J. W., R. Darlenski, I. Angelova-Fischer, N. Tsankov, and D. Basketter. 2008. Skin irritation and sensitization: Mechanisms and new approaches for risk assessment. Skin Pharmacol. Physiol 21 (3):124–35. doi:https://doi.org/10.1159/000131077.
- Fortugno, P., L. Furio, M. Teson, M. Berretti, M. E. Hachem, G. Zambruno, A. Hovnanian, and M. D’Alessio. 2012. The 420k LEKTI variant alters LEKTI proteolytic activation and results in protease deregulation: Implications for atopic dermatitis. Human Mol. Genet 21 (19):4187–200. doi:https://doi.org/10.1093/hmg/dds243.
- Fryer, A. A., A. Bianco, M. Hepple, P. W. Jones, R. C. Strange, and M. A. Spiteri. 2000. Polymorphism at the glutathione s-transferase GSTP1 Locus. Am. J. Respir. Crit. Care Med 161 (5):1437–42. doi:https://doi.org/10.1164/ajrccm.161.5.9903006.
- Fujii-Kuriyama, Y., and J. Mimura. 2005. Molecular mechanisms of AhR functions in the regulation of cytochrome P450 genes. Biochem. Biophys. Res. Commun. 338 (1):311–17. doi:https://doi.org/10.1016/j.bbrc.2005.08.162.
- Fujii, M. 2020. Current understanding of pathophysiological mechanisms of atopic dermatitis: Interactions among skin barrier dysfunction, immune abnormalities and pruritus. Biol. Pharm. Bull 43 (1):12–19. doi:https://doi.org/10.1248/bpb.b19-00088.
- Furue, M., G. Tsuji, C. Mitoma, T. Nakahara, T. Chiba, S. Morino-Koga, and H. Uchi. 2015. Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor. J. Dermatol. Sci 80 (2):83–88. doi:https://doi.org/10.1016/j.jdermsci.2015.07.011.
- Galbiati, V., A. Papale, C. L. Galli, M. Marinovich, and E. Corsini. 2014. Role of ROS and HMGB1 in contact allergen-induced IL-18 production in human keratinocytes. J. Invest. Dermatol 134 (11):2719–27. doi:https://doi.org/10.1038/jid.2014.203.
- Gangemi, S., R. A. Merendino, F. Guarneri, P. L. Minciullo, G. DiLorenzo, M. Pacor, and S. P. Cannavò. 2003. Serum levels of interleukin-18 and s-ICAM-1 in patients affected by psoriasis: Preliminary considerations. J. Eur. Acad. Dermatol. Venereol 17 (1):42–46. doi:https://doi.org/10.1046/j.1468-3083.2003.00647.x.
- Gao, P. S., N. M. Rafaels, D. Mu, T. Hand, T. Murray, M. Boguniewicz, T. Hata, L. Schneider, J. M. Hanifin, R. L. Gallo, et al. 2010. Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum. J. Allergy Clin. Immunol 125:798–806. doi:https://doi.org/10.1016/j.jaci.2010.03.016.
- Gao, W., J. Tan, A. Hüls, A. Ding, Y. Liu, M. S. Matsui, A. Vierkötter, J. Krutmann, T. Schikowski, L. Jin, et al. 2016. Genetic variants associated with skin aging in the Chinese Han population. J. Dermatol. Sci 86 (1):21–29. doi:https://doi.org/10.1016/j.jdermsci.2016.12.017.
- Gharagozlou, M., E. Farhadi, M. Khaledi, N. Behniafard, S. Sotoudeh, R. Salari, B. Darabi, S. M. Fathi, M. Mahmoudi, A. Aghamohammadi, et al. 2013. Association between the interleukin 6 genotype at position −174 and atopic dermatitis. J. Invest. Allergol. Clin. Immunol 23:89–93.
- Gibbs, B. F., N. Patsinakidis, and U. Raap. 2019. Role of the pruritic cytokine IL-31 in autoimmune skin diseases. Front Immunol 10:1383. doi:https://doi.org/10.3389/fimmu.2019.01383.
- Gibbs, N., J. Tye, and M. Norval. 2008. Recent advances in urocanic acid photochemistry, photobiology and photoimmunology. Photochem. Photobiol. Sci 7 (6):655–67. doi:https://doi.org/10.1039/b717398a.
- Ginsberg, G., S. Smolenski, D. Hattis, K. Z. Guyton, D. O. Johns, and B. Sonawane. 2009b. Genetic polymorphism in glutathione transferases (GST): Population distribution of GSTM1, T1, and P1 conjugating activity. J. Toxicol. Environ. Health B 12 (5–6):389–439. doi:https://doi.org/10.1080/15287394.2017.1286923.
- Ginsberg, G., S. Smolenski, P. Neafsey, D. Hattis, K. Walker, K. Z. Guyton, D. O. Johns, and B. Sonawane. 2009a. The influence of genetic polymorphisms on population variability in six xenobiotic-metabolizing enzymes. J. Toxicol. Environ. Health B 12 (5–6):307–33. doi:https://doi.org/10.1080/10937400903158318.
- González-Tarancón, R., R. Sanmartín, F. Lorente, E. Salvador-Rupérez, A. Hernández-Martín, L. Rello, J. Puzo, and Y. Gilaberte. 2020. Prevalence of FLG loss-of-function mutations R501X, 2282del4, and R2447X in Spanish children with atopic dermatitis. Pediatr. Dermatol 37 (1):98–102. doi:https://doi.org/10.1111/pde.14025.
- Goodman, W. A., A. D. Levine, J. V. Massari, H. Sugiyama, T. S. McCormick, and K. D. Cooper. 2009. IL-6 signaling in psoriasis prevents immune suppression by regulatory T cells. J. Immunol 183 (5):3170–32176. doi:https://doi.org/10.4049/jimmunol.0803721.
- Granum, B., and M. Løvik. 2002. The effect of particles on allergic immune responses. Toxicol. Sci 65 (1):7–17. doi:https://doi.org/10.1093/toxsci/65.1.7.
- Grimstad, Ø., Y. Sawanobori, C. Vestergaard, J. Bilsborough, U. B. Olsen, C. Grønhøj-Larsen, and K. Matsushima. 2009. Anti-interleukin-31-antibodies ameliorate scratching behaviour in NC/Nga mice: A model of atopic dermatitis. Exp. Dermatol 18 (1):35–43. doi:https://doi.org/10.1111/j.1600-0625.2008.00766.x.
- Gröne, A. 2002. Keratinocytes and cytokines. Vet. Immunol. Immunopathol 88 (1–2):1–12. doi:https://doi.org/10.1016/S0165-2427(02)00136-8.
- Grossman, R. M., J. Krueger, D. Yourish, A. Granelli-Piperno, D. P. Murphy, L. T. May, T. S. Kupper, P. B. Sehgal, and A. B. Gottlieb. 1989. Interleukin 6 is expressed in high levels of psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc. Natl. Acad. Sci. U. S. A 86 (16):6367–71. doi:https://doi.org/10.1073/pnas.86.16.6367.
- Guo, R., -F.-F. Li, M.-L. Chen, M.-Z. Ya, H.-L. He, and D. Li. 2015. The role of CGRP and CALCA T-692C single-nucleotide polymorphism in psoriasis vulgaris. Pharmazie 70 (2):88–93.
- Guzowski, D., A. Chandrasekaran, C. Gawel, J. Palma, J. Koenig, X. P. Wang, M. Dosik, M. Kaplan, C. C. Chu, S. Chavan, et al. 2005. Analysis of single nucleotide polymorphisms in the promoter region of interleukin-10 by denaturing high-performance liquid chromatography. J. Biomol. Tech 16 (2):154–66.
- Haarmann-Stemmann, T., C. Esser, and J. Krutmann. 2015. The Janus-faced role of aryl hydrocarbon receptor signaling in the skin: Consequences for prevention and treatment of skin disorders. J. Invest. Dermatol 135 (11):2572–76. doi:https://doi.org/10.1038/jid.2015.285.
- Haarmann-Stemmann, T., J. Abel, E. Fritsche, and J. Krutmann. 2012. The AhR-Nrf2 pathway in keratinocytes: On the road to chemoprevention. J. Invest. Dermatol 132 (1):7–9. doi:https://doi.org/10.1038/jid.2011.359.
- Hajeer, A. H., and I. V. Hutchinson. 2001. Influence of TNFα gene polymorphisms on TNFα production and disease. Human Immunol 62 (11):1191–99. doi:https://doi.org/10.1016/S0198-8859(01)00322-6.
- Halim, T. Y. F., R. H. Krauß, A. C. Sun, and F. Takei. 2012. Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation. Immunity 36 (3):451–63. doi:https://doi.org/10.1016/j.immuni.2011.12.020.
- Han, H., F. Roan, and S. F. Ziegler. 2017. The atopic march: Current insights into skin barrier dysfunction and epithelial cell-derived cytokines. Immunol. Rev 278 (1):116–30. doi:https://doi.org/10.1111/imr.12546.
- Han, Y. P., T. L. Tuan, M. Hughes, H. Wu, and W. L. Garner. 2001. Transforming growth factor-β- and tumor necrosis factor-α -mediated induction and proteolytic activation of MMP-9 in human skin. J. Biol. Chem 276 (25):22341–50. doi:https://doi.org/10.1074/jbc.M010839200.
- Hardwick, R. N., C. J. Betts, J. Whritenour, R. Sura, M. Thamsen, E. H. Kaufman, and K. Fabre. 2019. Drug-induced skin toxicity: Gaps in preclinical testing cascade as opportunities for complex in vitro models and assays. Lab. Chip 20 (2):199–214. doi:https://doi.org/10.1039/c9lc00519f.
- Harper, P. A., J. M. Y. Wong, M. S. M. Lam, and A. B. Okey. 2002. Polymorphisms in the human AH receptor. Chem.-Biol. Interact 141 (1–2):161–87. doi:https://doi.org/10.1016/S0009-2797(02)00071-6.
- Harris, J. E. 2017. Chemical-induced vitiligo. Dermatol. Clin 35 (2):151–61. doi:https://doi.org/10.1016/j.det.2016.11.006.
- Harting, J. R., A. Gleason, D. J. Romberger, S. G. Von Essen, F. Qiu, N. Alexis, and J. A. Poole. 2012. Chronic obstructive pulmonary disease patients have greater systemic responsiveness to ex vivo stimulation with swine dust extract and its components versus healthy volunteers. J. Toxicol. Environ. Health A 75 (24):1456–79. doi:https://doi.org/10.1080/15287394.2012.722186.
- Hartmann, K., N. Wagner, A. Rabenhorst, L. Pflanz, S. Leja, A. Förster, M. Gehring, A. Kapp, and U. Raap. 2013. Serum IL-31 levels are increased in a subset of patients with mastocytosis and correlate with disease severity in adult patients. J. Allergy Clin. Immunol 132. doi:https://doi.org/10.1016/j.jaci.2012.11.008.
- Häsler, J., and K. Strub. 2006. Alu elements as regulators of gene expression. Nucl Acids Res 34 (19):5491–97. doi:https://doi.org/10.1093/nar/gkl706.
- Hasse, S., N. C. J. Gibbons, H. Rokos, L. K. Marles, and K. U. Schallreuter. 2004. Perturbed 6-tetrahydrobiopterin recycling via decreased dihydropteridine reductase in vitiligo: More evidence for H2O2 stress. J. Invest. Dermatol 122 (2):307–13. doi:https://doi.org/10.1046/j.0022-202X.2004.22230.x.
- Hawro, T., R. Saluja, K. Weller, S. Altrichter, M. Metz, and M. Maurer. 2014. Interleukin-31 does not induce immediate itch in atopic dermatitis patients and healthy controls after skin challenge. Allergy 69 (1):113–17. doi:https://doi.org/10.1111/all.12316.
- Hayes, J. D., and R. C. Strange. 2000. Glutathione s-transferase polymorphisms and their biological consequences. Pharmacology 61 (3):154–66. doi:https://doi.org/10.1159/000028396.
- He, R., M. K. Oyoshi, J. Y. Wang, M. R. Hodge, H. Jin, and R. S. Geha. 2010. The prostaglandin D(2) receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge. J. Allergy Clin. Immunol 126 (4):784–90. doi:https://doi.org/10.1016/j.jaci.2010.07.006.
- Helmig, S., J. U. Seelinger, J. Döhrel, and J. Schneider. 2011. RNA expressions of AHR, ARNT and CYP1B1 are influenced by AHR Arg554Lys polymorphism. Mol. Genet. Metab 104 (1–2):180–84. doi:https://doi.org/10.1016/j.ymgme.2011.06.009.
- Hennighausen, L., and G. W. Robinson. 2008. Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B. Genes Dev 22 (6):711–21. doi:https://doi.org/10.1101/gad.1643908.
- Hermanns, H. M. 2015. Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology. Cytokine Growth Factor Rev 26 (5):545–58. doi:https://doi.org/10.1016/j.cytogfr.2015.07.006.
- Hidaka, T., E. Ogawa, E. H. Kobayashi, T. Suzuki, R. Funayama, T. Nagashima, T. Fujimura, S. Aiba, K. Nakayama, R. Okuyama, et al. 2017. The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin. Nat. Immunol 18 (1):64–73. doi:https://doi.org/10.1038/ni.3614.
- Hidaka, T., T. Fujimura, and S. Aiba. 2019. Aryl hydrocarbon receptor modulates carcinogenesis and maintenance of skin cancers. Front. Med 6. doi:https://doi.org/10.3389/fmed.2019.00194.
- Hildebrand, C. E., F. J. Gonzalez, O. W. Mcbride, and D. W. Nebert. 1985. Assignment of the human 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 gene to chromosome 15. Nucl Acids Res 13 (6):2009–16. doi:https://doi.org/10.1093/nar/13.6.2009.
- Hill, J., D. Paslin, and P. W. Wertz. 2006. A new covalently bound ceramide from human stratum corneum - ω-hydroxyacylphytosphingosine. Int. J. Cosmet. Sci 28 (3):225–30. doi:https://doi.org/10.1111/j.1467-2494.2006.00324.x.
- Hoffjan, S., I. Ostrovnaja, D. Nicolae, D. L. Newman, R. Nicolae, R. Gangnon, L. Steiner, K. Walker, R. Reynolds, D. Greene, et al. 2004. Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy. J. Allergy Clin. Immunol 113:511–18. doi:https://doi.org/10.1016/j.jaci.2003.10.044.
- Hong, C. H., H. S. Yu, Y. C. Ko, W. C. Chang, H. Y. Chuang, G. S. Chen, and C. H. Lee. 2012. Functional regulation of interleukin-31 production by its genetic polymorphism in patients with extrinsic atopic dermatitis. Acta Derm. Venereol 92 (4):430–32. doi:https://doi.org/10.2340/00015555-1203.
- Hong, C. H., S. H. Lin, B. E. Clausen, and C. H. Lee. 2020. Selective AhR knockout in langerin-expressing cells abates langerhans cells and polarizes Th2/Tr1 in epicutaneous protein sensitization. Proc. Natl. Acad. Sci. U.S.A 117 (23):12980–90. doi:https://doi.org/10.1073/pnas.1917479117.
- Hong, Y., B. Song, H. D. Chen, and X. H. Gao. 2015. Melanocytes and skin immunity. J. Invest. Dermatol 17 (1):37–39. doi:https://doi.org/10.1038/jidsymp.2015.14.
- Hoovers, J. M., E. Redeker, F. Speleman, J. W. Höppener, S. Bhola, J. Bliek, N. van Roy, N. J. Leschot, A. Westerveld, and M. Mannens. 1993. High-resolution chromosomal localization of the human calcitonin/CGRP/IAPP gene family members. Genomics 15 (3):525–29. doi:https://doi.org/10.1006/geno.1993.1104.
- Hoshino, T., R. H. Wiltrout, and H. A. Young. 1999. IL-18 is a potent coinducer of IL-13 in NK and T cells: A new potential role for IL-18 in modulating the immune response. J. Immunol 162:5070–77.
- Hoskins, A., P. Wu, S. Reiss, and R. Dworski. 2013. Glutathione S-Transferase P1 Ile105Val polymorphism modulates allergen-induced airway inflammation in human atopic asthmatics in vivo. Clin. Exp. Allergy 43 (5):527–34. doi:https://doi.org/10.1111/cea.12086.
- Hoste, E., P. Kemperman, M. Devos, G. Denecker, S. Kezic, N. Yau, B. Gilbert, S. Lippens, P. De Groote, R. Roelandt, et al. 2011. Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin. J. Invest. Dermatol 131 (11):2233–41. doi:https://doi.org/10.1038/jid.2011.153.
- Huang, H., and L. Li. 2006. Study on general situation of occupational trichloroethylene-induced medicamentosa-like dermatitis. Chin. Occup. Med 33:323–25.
- Huang, M., G.-D. Huang, and D. Peng. 2017. Angiotensin-converting enzyme I/D polymorphism and susceptibility of psoriasis. Biomed. Res 28:5450–53.
- Hui, C. C. K., A. Yu, D. Heroux, L. Akhabir, A. J. Sandford, H. Neighbour, and J. A. Denburg. 2015. Thymic stromal lymphopoietin (TSLP) secretion from human nasal epithelium is a function of TSLP genotype. Mucosal Immunol 8 (5):993–99. doi:https://doi.org/10.1038/mi.2014.126.
- Hwang, J.-H., and B. M. Lee. 2007. Inhibitory effects of plant extracts on tyrosinase, l-DOPA oxidation, and melanin synthesis. J. Toxicol. Environ. Health A 70 (5):393–407. doi:https://doi.org/10.1080/10937400600882871.
- Ibrahim, G. H., M. T. ElTabbakh, A. H. A. Gomaa, and E. A. Mohamed. 2012. Interleukin-18 gene polymorphisms in Egyptian patients with allergic diseases. Am. J. Rhinol. Allergy 26 (5):385–89. doi:https://doi.org/10.2500/ajra.2012.26.3806.
- Imboden, M., A. Nieters, A. J. Bircher, M. Brutsche, N. Becker, M. Wjst, U. Ackermann-Liebrich, W. Berger, and N. M. Probst-Hensch. 2006. Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA). Clin. Mol. Allergy 4 (1):1–9. doi:https://doi.org/10.1186/1476-7961-4-9. SAPALDIA Team.
- Indhumathi, S., M. Rajappa, L. Chandrashekar, P. H. Ananthanarayanan, D. M. Thappa, and V. S. Negi. 2017. T helper-2 cytokine/regulatory T-cell gene polymorphisms and their relation with risk of psoriasis in a South Indian Tamil cohort. Human Immunol 78 (2):209–15. doi:https://doi.org/10.1016/j.humimm.2016.12.006.
- Isac, L., and S. Jiquan. 2019. Interleukin 10 promotor gene polymorphism in the pathogenesis of psoriasis. Acta. Dermatovenerol.Alp. Pannonica Adriat 28:119–23. doi:https://doi.org/10.15570/actaapa.2019.29.
- Italiani, P., and D. Boraschi. 2014. From monocytes to M1/M2 macrophages: Phenotypical vs. functional differentiation. Front. Immunol 5:514. doi:https://doi.org/10.3389/fimmu.2014.00514.
- Ito, T., Y. H. Wang, O. Duramad, T. Hori, G. J. Delespesse, N. Watanabe, F. X. F. Qin, Z. Yao, W. Cao, and Y. J. Liu. 2005. TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J. Exp. Med 202 (9):1213–23. doi:https://doi.org/10.1084/jem.20051135.
- Ito, Y., T. Satoh, H. Yokozeki, H. Yokozeki, A. F. Walls, and H. Yokozeki. 2011. Basophils infltrate skin lesions of eosinophilic pustular folliculitis (Ofuji’s Disease). Allergy 66 (8):1107–13. doi:https://doi.org/10.1111/j.1398-9995.2011.02570.x.
- Jäckh, C., E. Fabian, B. Van Ravenzwaay, and R. Landsiedel. 2012. Relevance of xenobiotic enzymes in human skin in vitro models to activate pro-sensitizers. J. Immunotoxicol 9 (4):426–38. doi:https://doi.org/10.3109/1547691X.2012.664578.
- Ji, H., and X. K. Li. 2016. Oxidative stress in atopic dermatitis. Oxid. Med. Cell. Longev 2016:2721469. doi:https://doi.org/10.1155/2016/2721469.
- Jian, M. Y., P. K. Woon, L. S. Can, P. L. Hin, and C. Y. Mimi. 2005. Green tea intake. ACE gene polymorphism and breast cancer risk among Chinese women in Singapore. Carcinogenesis 26 (8):1389–94. doi:https://doi.org/10.1093/carcin/bgi080.
- Jimbow, K., H. Chen, J. S. Park, and P. D. Thomas. 2001. Increased sensitivity of melanocytes to oxidative stress and abnormal expression of tyrosinase-related protein in vitiligo. Br. J. Dermatol 144 (1):55–65. doi:https://doi.org/10.1046/j.1365-2133.2001.03952.x.
- Jones, G. W., R. M. McLoughlin, V. J. Hammond, C. R. Parker, J. D. Williams, R. Malhotra, J. Scheller, A. S. Williams, S. Rose-John, N. Topley, et al. 2010. Loss of CD4+T cell IL-6R expression during inflammation underlines a role for il-6 trans signaling in the local maintenance of Th17 cells. J. Immunol 184 (4):2130–39. doi:https://doi.org/10.4049/jimmunol.0901528.
- Jux, B., S. Kadow, and C. Esser. 2009. Langerhans cell maturation and contact hypersensitivity are impaired in aryl hydrocarbon receptor-null mice. J. Immunol 182 (11):6709–17. doi:https://doi.org/10.4049/jimmunol.0713344.
- Jux, B., S. Kadow, S. Luecke, A. Rannug, J. Krutmann, and C. Esser. 2011. The aryl hydrocarbon receptor mediates UVB radiation-induced skin tanning. J. Invest. Dermatol 131 (1):203. doi:https://doi.org/10.1038/jid.2010.269.
- Kabata, H., and D. Artis. 2019. Neuro-immune crosstalk and allergic inflammation. J. Clin. Invest 129 (4):1475–82. doi:https://doi.org/10.1172/JCI124609.
- Kalina, U., K. Ballas, N. Koyama, D. Kauschat, C. Miething, J. Arnemann, H. Martin, D. Hoelzer, and O. G. Ottmann. 2000. Genomic organization and regulation of the human interleukin-18 gene. Scand. J. Immunol 52 (6):525–30. doi:https://doi.org/10.1046/j.1365-3083.2000.00836.x.
- Kanda, N., and S. Watanabe. 2002. Substance P enhances the production of interferon-induced protein of 10 kDa by human keratinocytes in synergy with interferon-c. J. Invest. Dermatol 119 (6):1290–97. doi:https://doi.org/10.1046/j.1523-1747.2002.19626.x.
- Kantele, A., J. Zivny, M. Hakkinen, C. O. Elson, and J. Mestecky. 1999. Differential homing commitments of antigen-specific T cells after oral or parenteral immunization in humans. J. Immunol 162 (9):5173–77.
- Kaplan, D. H., B. Z. Igyártó, and A. A. Gaspari. 2012. Early immune events in the induction of allergic contact dermatitis. Nat. Rev. Immunol 12 (2):114–24. doi:https://doi.org/10.1038/nri3150.
- Kaplanski, G., V. Marin, F. Montero-Julian, A. Mantovani, and C. Farnarier. 2003. IL-6: A regulator of the transition from neutrophil to monocyte recruitment during inflammation. Trends Immunol 24 (1):25–29. doi:https://doi.org/10.1016/S1471-4906(02)00013-3
- Karam, R. A., H. E. Zidan, and M. H. Khater. 2014. Polymorphisms in the TNF-α and IL-10 gene promoters and risk of psoriasis and correlation with disease severity. Cytokine 66 (2):101–05. doi:https://doi.org/10.1016/j.cyto.2014.01.008.
- Kasraie, S., and T. Werfel. 2013. Role of macrophages in the pathogenesis of atopic dermatitis. Mediators Inflamm 2013:942375. doi:https://doi.org/10.1155/2013/942375.
- Kato, T., Y. Tsunemi, H. Saeki, S. Shibata, T. Sekiya, K. Nakamura, T. Kakinuma, S. Kagami, H. Fujita, Y. Tada, et al. 2009. Interferon-18 gene polymorphism −137 G/C is associated with susceptibility to psoriasis vulgaris but not with atopic dermatitis in Japanese patients. letters to the editor/. J. Dermatol. Sci. 53 (2):146–65. doi:https://doi.org/10.1016/j.jdermsci.2008.08.016.
- Kawasaki, H., K. Nagao, A. Kubo, T. Hata, A. Shimizu, H. Mizuno, T. Yamada, and M. Amagai. 2012. Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice. J. Allergy Clin. Immunol 129 (6):1538–1546.e6. doi:https://doi.org/10.1016/j.jaci.2012.01.068.
- Kerkvliet, N. I. 2009. AHR-mediated immunomodulation: The role of altered gene transcription. Biochem. Pharmacol 77 (4):746–60. doi:https://doi.org/10.1016/j.bcp.2008.11.021.
- Keyal, U., A. K. Bhatta, and X. L. Wang. 2016. Photodynamic therapy for the treatment of different severity of acne: A systematic review. Photodiagnosis Photodyn. Ther 14:191–99. doi:https://doi.org/10.1016/j.pdpdt.2016.04.005.
- Kezic, S., G. M. O’Regan, N. Yau, A. Sandilands, H. Chen, L. E. Campbell, K. Kroboth, R. Watson, M. Rowland, W. H. I. McLean, et al. 2011. Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity. Eur J. Allergy Clin. Immunol 66 (7):934–40. doi:https://doi.org/10.1111/j.1398-9995.2010.02540.x.
- Khatri, R., K. Mukhopadhyay, K. K. Verma, G. Sethuraman, and A. Sharma. 2011. Genetic predisposition to parthenium dermatitis in an Indian cohort due to lower-producing genotypes of interleukin-10 (−) 1082 G>A and (−) 819 C>T loci but no association with interferon-γ (+) 874 A>T locus. Br. J. Dermatol 165 (1):115–22. doi:https://doi.org/10.1111/j.1365-2133.2011.10248.x.
- Kim, B. S., F. Miyagawa, Y.-H. Cho, C. L. Bennett, B. E. Clausen, and S. I. Katz. 2009. Keratinocytes function as accessory cells for presentation of endogenous antigen expressed in the epidermis. J Invest Dermatol 129 (12):2805–17. doi:https://doi.org/10.1038/jid.2009.176.
- Kim, B. S., K. Wang, M. C. Siracusa, S. A. Saenz, J. R. Brestoff, L. A. Monticelli, M. Noti, E. D. T. Wojno, T. C. Fung, M. Kubo, et al. 2014. Basophils promote innate lymphoid cell responses in inflamed skin. J. Immunol 193 (7):3717–25. doi:https://doi.org/10.4049/jimmunol.1401307.
- Kim, B. S., M. C. Siracusa, S. A. Saenz, M. Noti, L. A. Monticelli, G. F. Sonnenberg, M. R. Hepworth, A. S. Van Voorhees, M. R. Comeau, and D. Artis. 2013. TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation. Sci. Transl. Med 5 (170):1–12. doi:https://doi.org/10.1126/scitranslmed.3005374.
- Kim, B. S. 2015. Innate lymphoid cells in the skin. J. Invest. Dermatol 135 (3):673–78. doi:https://doi.org/10.1038/jid.2014.401.
- Kim, B.-Y., S. J. Kwack, J. Y. Lee, S. Kacew, and B.-M. Lee. 2021. Current opinion on risk assessment of cosmetics. J. Toxicol. Environ. Health B 24 (4):137–61. doi:https://doi.org/10.1080/10937404.2021.1907264.
- Kim, E., J. E. Lee, J. H. Namkung, J. H. Park, S. Kim, E. S. Shin, E. Y. Cho, and J. M. Yang. 2007. Association of the single-nucleotide polymorphism and haplotype of the interleukin 18 gene with atopic dermatitis in Koreans. Clin. Exp. Allergy 37 (6):865–71. doi:https://doi.org/10.1111/j.1365-2222.2007.02717.x.
- Kim, M. K., K.-B. Kim, H. S. Kim, and B.-M. Lee. 2019. Alternative skin sensitization prediction and risk assessment using proinflammatory biomarkers, interleukin-1 beta (IL-1β) and inducible nitric oxide synthase (iNOS). J. Toxicol. Environ. Health A 82 (5):361–78. doi:https://doi.org/10.1080/15287394.2019.1609183.
- Kim, M. K., K.-Y. Kim, K. Yoon, S. Kacew, H. S. Kim, and B.-M. Lee. 2018. IL-1α and IL-1β as alternative biomarkers for risk assessment and the prediction of skin sensitization potency. J. Toxicol. Environ. Health A 81 (17):830–43. doi:https://doi.org/10.1080/15287394.2018.1494474.
- Kimber, I., M. Cumberbatch, R. J. Dearman, M. Bhushan, and C. E. M. Griffiths. 2000. Cytokines and chemokines in the initiation and regulation of epidermal Langerhans cell mobilization. Br. J. Dermatol 142 (3):401–12. doi:https://doi.org/10.1046/j.1365-2133.2000.03349.x.
- Kirchmeier, P., A. Zimmer, B. Bouadjar, B. Rösler, and J. Fischer. 2017. Whole-exome-sequencing reveals small deletions in CASP14 in patients with autosomal recessive inherited ichthyosis. Acta Derm. Venereol 97 (1):102–04. doi:https://doi.org/10.2340/00015555-2510.
- Kita, H. 2013. Eosinophils: Multifunctional and distinctive properties. Int. Arch. Allergy Immunol 161 (s2):3–9. doi:https://doi.org/10.1159/000350662.
- Klebow, S., M. Hahn, A. Nikoalev, F. T. Wunderlich, N. Hövelmeyer, S. H. Karbach, A. Waisman, and B. Ryffel. 2016. IL-6 signaling in myelomonocytic cells is not crucial for the development of IMQ-induced psoriasis. PLoS ONE 11 (3):1–15. doi:https://doi.org/10.1371/journal.pone.0151913.
- Klechevsky, E. 2015. Functional diversity of human dendritic cells. Adv. Exp. Med. Biol 850:43–54. doi:https://doi.org/10.1007/978-3-319-15774-0.
- Klonowska, J., J. Gleń, R. J. Nowicki, and M. Trzeciak. 2018. New cytokines in the pathogenesis of atopic dermatitis – New therapeutic targets. Int. J. Mol. Sci 19. doi:https://doi.org/10.3390/ijms19103086.
- Knight, J. A. 2000. Review: Free radicals, antioxidants, and the immune system. Ann. Clin. LabSci. 30 (2):145–58.
- Konishi, H., H. Tsutsui, T. Murakami, S. Yumikura-Futatsugi, K. I. Yamanaka, M. Tanaka, Y. Iwakura, N. Suzuki, K. Takeda, S. Akira, et al. 2002. IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions. Proc. Natl. Acad. Sci. U.S.A 99 (17):11340–45. doi:https://doi.org/10.1073/pnas.152337799.
- Kroeger, K. M., and L. J. Abraham. 1996. Identification of an AP-2 element in the −323 to −285 region of the TNF-a gene. Biochem. Mol. Biol. Int 40 (1):43–51. doi:https://doi.org/10.1080/15216549600201512.
- Krueger, J. G. 2002. The immunologic basis for the treatment of psoriasis with new biologic agents. J. Am. Acad. Dermatol. 46 (1):1–23. doi:https://doi.org/10.1067/mjd.2002.120568.
- Kruse, S., J. Kuehr, M. Moseler, M. V. Kopp, T. Kurz, K. A. Deichmann, P. S. Foster, and J. Mattes. 2003. Polymorphisms in the IL18 gene are associated with specific sensitization to common allergens and allergic rhinitis. J. Allergy Clin. Immunol. 111 (1):117–22. doi:https://doi.org/10.1067/mai.2003.43.
- Kunsleben, N., U. Rüdrich, M. Gehring, N. Novak, A. Kapp, and U. Raap. 2015. IL-31 induces chemotaxis, calcium mobilization, release of reactive oxygen species, and CCL26 in eosinophils, which are capable to release IL-31. J. Invest. Dermatol. 135 (7):1908–11. doi:https://doi.org/10.1038/jid.2015.106.
- Kuo, C. T., and J. M. Leiden. 1999. Transcriptional regulation of T lymphocyte development and function. Annu. Rev. Immunol. 17 (1):149–87. doi:https://doi.org/10.1146/annurev.immunol.17.1.149.
- Kuoppala, A., K. A. Lindstedt, J. Saarinen, P. T. Kovanen, and J. O. Kokkonen. 2000. Inactivation of bradykinin by angiotensin-converting enzyme and by carboxypeptidase N in human plasma. Am. J. Physiol. Heart Circ. Physiol. 278 (4):H1069–H1074. doi:https://doi.org/10.1152/ajpheart.2000.278.4.H1069.
- Kusumawati, L. R. 2017. The role of single nucleotide interleukin-6 (IL-6) polymorphism gene in psoriasis vulgaris patients at Haji Adam Malik Central Hospital, Medan-Indonesia. Bali Med. J. 1:78–81. doi:https://doi.org/10.15562/bmj.v7i1.780.
- Kwon, Y. C., H. S. Kim, and B.-M. Lee. 2020. Detoxifying effects of optimal hyperoxia (40% oxygenation) exposure on benzo[a]pyrene-induced toxicity in human keratinocytes. J. Toxicol. Environ. Health A 83 (2):82–94. doi:https://doi.org/10.1080/15287394.2020.1730083.
- Lagrelius, M., C. F. Wahlgren, M. Bradley, E. Melén, I. Kull, A. Bergström, and C. Lidén. 2020. Filaggrin gene mutations in relation to contact allergy and hand eczema in adolescence. Contact Derm 82 (3):147–52. doi:https://doi.org/10.1111/cod.13444.
- Lai, Y., and R. L. Gallo. 2008. Toll-like receptors in skin infectious and inflammatory diseases. Infect. Disord. Drug Targets 8 (3):144–55. doi:https://doi.org/10.2174/1871526510808030144.
- Lan, C. C., . E., H. P. Tu, C. S. Wu, Y. C. Ko, H. S. Yu, Y. W. Lu, W. C. Li, Y. C. Chen, and G. S. Chen. 2011. Distinct SPINK5 and IL-31 polymorphisms are associated with atopic eczema and non-atopic hand dermatitis in Taiwanese nursing population. Exp. Dermatol 20 (12):975–79. doi:https://doi.org/10.1111/j.1600-0625.2011.01374.x.
- Lange, M., J. Gleń, M. Zabłotna, B. Nedoszytko, M. Sokołowska-Wojdyło, K. Rębała, H. Ługowska-Umer, M. Niedoszytko, A. Górska, M. Sikorska, et al. 2017. Interleukin-31 polymorphisms and serum IL-31 level in patients with mastocytosis: Correlation with clinical presentation and pruritus. Acta Derm. Venereol. 97 (1):47–53. doi:https://doi.org/10.2340/00015555-2474.
- Larsson, M., D. Fraccalvieri, C. D. Andersson, L. Bonati, A. Linusson, and P. L. Andersson. 2018. Identification of potential aryl hydrocarbon receptor ligands by virtual screening of industrial chemicals. Environ. Sci. Pollut. Res. 25 (3):2436–49. doi:https://doi.org/10.1007/s11356-017-0437-9.
- Lauritano, D., G. Ronconi, A. Caraffa, C. E. Gallenga, S. K. Kritase, P. Emidio, S. Martinotti, G. Tetèh, R. Rossi, and P. Conti. 2020. New aspect of allergic contact dermatitis, an inflammatory skin disorder mediated by mast cells: Can IL-38 help? Med. Hypotheses. 139:109687. doi:https://doi.org/10.1016/j.mehy.2020.109687.
- Lauw, F. N., D. Pajkrt, C. E. Hack, M. Kurimoto, S. J. H. van Deventer, and T. van der Poll. 2000. Proinflammatory effects of IL-10 during human endotoxemia. J. Immunology 165 (5):2783–89. doi:https://doi.org/10.4049/jimmunol.165.5.2783.
- Laverdet, B., A. Danigo, D. Girard, L. Magy, C. Demiot, and A. Desmoulière. 2015. Skin innervation: Important roles during normal and pathological cutaneous repair. Histol Histopathol 30 (8):875–92. doi:https://doi.org/10.14670/HH-11-610.
- Le Beau, M. M., L. A. Carver, R. Espinosa, J. V. Schmidt, and C. A. Bradfield. 1994. Chromosomal localization of the human AHR locus encoding the structural gene for the Ah receptor to 7p21→p15. Cytogenet. Cell Genet 66 (3):172–76. doi:https://doi.org/10.1159/000133694.
- LeBien, T. W., and T. F. Tedder. 2008. B lymphocytes: How they develop and function. Blood 112 (5):1570–80. doi:https://doi.org/10.1182/blood-2008-02-078071.
- Lee, A.-Y., S.-H. Ok, R. B. Subbarao, J.-Y. Kim, S. I. Bae, Y. Hwang, S. Tak, and J.-T. Sohn. 2020. Molecular mechanism of epidermal barrier dysfunction as primary abnormalities. Int. J. Mol. Sci. 17 (1):21. doi:https://doi.org/10.3390/ijms21041194.
- Lee, F., and D. A. Lawrence. 2018. From infections to anthropogenic inflicted pathologies: Involvement of immune balance. J. Toxicol. Environ. Health B 21 (1):24–46. doi:https://doi.org/10.1080/10937404.2017.1412212.
- Lee, J. K., J. K. Seok, I. Cho, G. Yang, K.-B. Kim, S. J. Kwack, H. C. Kang, -Y.-Y. Cho, H. S. Lee, and J. Y. Lee. 2021. Topical application of celastrol alleviates atopic dermatitis symptoms mediated through the regulation of thymic stromal lymphopoietin and group 2 innate lymphoid cells. J. Toxicol. Environ. Health A 84 (22):922–31. doi:https://doi.org/10.1080/15287394.2021.1955785.
- Lee, J., D. H. Cho, and H. J. Park. 2015. IL-18 and cutaneous inflammatory diseases. Int. J. Mol. Sci. 16 (12):29357–69. doi:https://doi.org/10.3390/ijms161226172.
- Lee, Y. H., S. J. Choi, J. D. Ji, and G. G. Song. 2012. Associations between interleukin-10 polymorphisms and susceptibility to psoriasis: A meta-analysis. Inflamm. Res. 61 (7):657–63. doi:https://doi.org/10.1007/s00011-012-0458-2.
- Leitch, C. S., E. Natafji, C. Yu, S. Abdul-Ghaffar, N. Madarasingha, Z. C. Venables, R. Chu, P. M. Fitch, A. J. Muinonen-Martin, L. E. Campbell, et al. 2016. Filaggrin-null mutations are associated with increased maturation markers on Langerhans cells. J. Allergy Clin. Immunol. 138:482–490.e7. doi:https://doi.org/10.1016/j.jaci.2015.11.040.
- Leme, D. M., A. Sehr, T. Grummt, J. P. Gonçalves, T. Jacomasso, S. M. B. Winnischofer, F. B. Potrich, C. C. Oliveira, E. S. Trindade, and D. P. Oliveira. 2018. In vitro characterization of cutaneous immunotoxicity of immortalized human keratinocytes (HaCaT) exposed to reactive and disperse textile dyes. J. Toxicol. Environ. Health A 81 (13):589–603. doi:https://doi.org/10.1080/15287394.2018.1464981.
- Leung, D. Y. M., and T. Bieber. 2003. Atopic dermatitis. Lancet 361 (9352):151–60. doi:https://doi.org/10.1016/S0140-6736(03)12193-9.
- Leyva-Castillo, J. M., C. Galand, S. Mashiko, R. Bissonnette, A. McGurk, S. F. Ziegler, C. Dong, A. N. J. McKenzie, M. Sarfati, and R. S. Geha. 2020. ILC2 activation by keratinocyte-derived IL-25 drives IL-13 production at sites of allergic skin inflammation. J. Allergy Clin. Immunol 145 (6):1606–1614.e4. doi:https://doi.org/10.1016/j.jaci.2020.02.026.
- Leyva-Castillo, J. M., P. Hener, H. Jiang, and M. Li. 2013. TSLP produced by keratinocytes promotes allergen sensitization through skin and thereby triggers atopic march in mice. J. Invest. Dermatol. 133 (1):154–63. doi:https://doi.org/10.1038/jid.2012.239.
- Leyvraz, C., R. P. Charles, I. Rubera, M. Guitard, S. Rotman, B. Breiden, K. Sandhoff, and E. Hummler. 2005. The epidermal barrier function is dependent on the serine protease CAP1/Prss8. J. Cell Biol 170 (3):487–96. doi:https://doi.org/10.1083/jcb.200501038.
- Li, C., G. Wang, Y. Gao, L. Liu, and T. Gao. 2007a. TNF-α Gene Promoter −238G>A and −308G>A polymorphisms alter risk of psoriasis vulgaris: A meta-analysis. J. Invest. Dermatol. 127 (8):1886–92. doi:https://doi.org/10.1038/sj.jid.5700822.
- Li, H., Y. Dai, H. Huang, L. Li, S. Leng, J. Cheng, Y. Niu, H. Duan, Q. Liu, X. Zhang, et al. 2007b. HLA-B*1301 as a biomarker for genetic susceptibility to hypersensitivity dermatitis induced by trichloroethylene among workers in China. Environ. Health. Perspect. 115 (11):1553–56. doi:https://doi.org/10.1289/ehp.10325.
- Li, Z. Z., W. L. Zhong, H. Hu, X. F. Chen, W. Zhang, H. Y. Huang, B. Yu, and X. Dou. 2019. Aryl hydrocarbon receptor polymorphisms are associated with dry skin phenotypes in Chinese patients with atopic dermatitis. Clin. Exp. Dermatol. 44 (6):613–19. doi:https://doi.org/10.1111/ced.13841.
- Lidén, C. 1986. Lichen planus in relation to occupational and non‐occupational exposure to chemicals. Br. J. Dermatol. 115 (1):23–31. doi:https://doi.org/10.1111/j.1365-2133.1986.tb06216.x.
- Liu, Y. J., V. Soumelis, N. Watanabe, T. Ito, Y. H. Wang, R. D. W. Malefyt, M. Omori, B. Zhou, and S. F. Ziegler. 2007. TSLP: An epithelial cell cytokine that regulates Tcell differentiation by conditioning dendritic cell maturation. Annu. Rev. Immunol 25 (1):193–219. doi:https://doi.org/10.1146/annurev.immunol.25.022106.141718.
- Lowe, G. C., C. L. Henderson, R. H. Grau, C. B. Hansen, R. D. Sontheimer, and R. D. Sontheimer. 2011. A systematic review of drug-induced subacute cutaneous lupus erythematosus. Br. J. Dermatol. 164 (3):465–72. doi:https://doi.org/10.1111/j.1365-2133.2010.10110.x.
- Luckheeram, R. V., R. Zhou, A. D. Verma, and B. Xia 1. 2012. CD4+T cells: Differentiation and functions. Clin. Dev. Immunol. 2012:1–12. doi:https://doi.org/10.1155/2012/925135.
- Luecke, S., M. Backlund, B. Jux, C. Esser, J. Krutmann, and A. Rannug. 2010. The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis. Pigment Cell Melanoma Res 23 (6):828–33. doi:https://doi.org/10.1111/j.1755-148X.2010.00762.x.
- Lundwall, Å., and M. Brattsand. 2008. Kallikrein-related peptidases. Cell. Mol. Life Sci. 65 (13):2019–38. doi:https://doi.org/10.1007/s00018-008-8024-3.
- Madden, J. C., S. Webb, S. J. Enoch, H. E. Colley, C. Murdoch, R. Shipley, P. Sharma, C. Yang, and M. T. D. Cronin. 2017. In silico prediction of skin metabolism and its implication in toxicity assessment. Comput. Toxicol. 3:44–57. doi:https://doi.org/10.1016/j.comtox.2017.07.001.
- Maier, E., D. Werner, A. Duschl, B. Bohle, and J. Horejs-Hoeck. 2014. Human Th2 but not Th9 cells release IL-31 in a STAT6/NF-ΚB–dependent way. J. Immunol. 193 (2):645–554. doi:https://doi.org/10.4049/jimmunol.1301836.
- Majtan, J., and V. Majtan. 2011. Dimethyl sulfoxide attenuates TNF-α-Induced production of MMP-9 in human keratinocytes. J. Toxicol. Environ. Health A 74 (20):1319–22. doi:https://doi.org/10.1080/15287394.2011.600661.
- Malissen, B., S. Tamoutounour, and S. Henri. 2014. The origins and functions of dendritic cells and macrophages in the skin. Nat. Rev. Immunol. 14 (6):417–28. doi:https://doi.org/10.1038/nri3683.
- Marchant, G. E. 2000. Genetic susceptibility and biomarkers in toxic injury litigation. Am Bar Assoc J 41:67–109.
- Margolis, D. J., B. Kim, A. J. Apter, J. Gupta, O. Hoffstad, M. Papadopoulos, and N. Mitra. 2014. Thymic stromal lymphopoietin variation, filaggrin loss of function, and the persistence of atopic dermatitis. JAMA Dermatol 150 (3):254–59. doi:https://doi.org/10.1001/jamadermatol.2013.7954.
- Mathachan, S. R., A. Khurana, R. K. Gautam, A. Kulhari, L. Sharma, and K. Sardana. 2021. Does oxidative stress correlate with disease activity and severity in vitiligo? An analytical study. J. Cosmet. Dermatol. 20 (1):352–59. doi:https://doi.org/10.1111/jocd.13499.
- Matsui, T., K. Miyamoto, A. Kubo, H. Kawasaki, T. Ebihara, K. Hata, S. Tanahashi, S. Ichinose, I. Imoto, J. Inazawa, et al. 2011. SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing. EMBO Mol. Med 3 (6):320–33. doi:https://doi.org/10.1002/emmm.201100140.
- McAleer, M. A., and A. D. Irvine. 2013. The multifunctional role of filaggrin in allergic skin disease. J. Allergy Clin. Immunol. 131 (2):280–91. doi:https://doi.org/10.1016/j.jaci.2012.12.668.
- McCarty, K. M., L. Ryan, E. A. Houseman, P. L. Williams, D. P. Miller, Q. Quamruzzaman, M. Rahman, G. Mahiuddin, T. Smith, E. Gonzalez, et al. 2007. A case-control study of GST polymorphisms and arsenic related skin lesions. Environ. Health 6 (1):5. doi:https://doi.org/10.1186/1476-069X-6-5.
- McFadden, J. P., P. Puangpet, D. A. Basketter, R. J. Dearman, and I. Kimber. 2013. Why does allergic contact dermatitis exist? Br. J. Dermatol. 168 (4):692–99. doi:https://doi.org/10.1111/bjd.12145.
- Millard, T. P., A. A. Fryer, and J. M. McGregor. 2008. A protective effect of glutathione-s-transferase GSTP1*Val 105 against polymorphic light eruption. J. Invest. Dermatol. 128 (8):1901–05. doi:https://doi.org/10.1038/jid.2008.14.
- Mimura, J., M. Ema, K. Sogawa, and Y. Fujii-Kuriyama. 1999. Identification of a novel mechanism of regulation of Ah (dioxin) receptor function. Genes Dev 13 (1):20–25. doi:https://doi.org/10.1101/gad.13.1.20.
- Miyake, Y., S. Hitsumoto, K. Tanaka, and M. Arakawa. 2015. Association between TSLP polymorphisms and eczema in Japanese women: The Kyushu Okinawa maternal and child health study. Inflammation 38 (4):1663–68. doi:https://doi.org/10.1007/s10753-015-0143-z.
- Mlak, R., I. Homa-Mlak, T. Powrózek, B. Mackiewicz, M. Michnar, P. Krawczyk, M. Dziedzic, R. Rubinsztajn, R. Chazan, J. Milanowski, et al. 2016. Impact of I/D polymorphism of ACE gene on risk of development and course of chronic obstructive pulmonary disease. Arch. Med. Sci. 12:279–87. doi:https://doi.org/10.5114/aoms.2015.50757.
- Moniaga, C. S., G. Egawa, H. Kawasaki, M. Hara-Chikuma, T. Honda, H. Tanizaki, S. Nakajima, A. Otsuka, H. Matsuoka, A. Kubo, et al. 2010. Flaky tail mouse denotes human atopic dermatitis in the steady state and by topical application with Dermatophagoides pteronyssinus extract. Am. J. Pathol. 176 (5):2385–93. doi:https://doi.org/10.2353/ajpath.2010.090957.
- Moyer, A. M., O. E. Salavaggione, T. Y. Wu, I. Moon, B. W. Eckloff, M. A. T. Hildebrandt, D. J. Schaid, E. D. Wieben, and R. M. Weinshilboum. 2008. Glutathione S-transferase P1: Gene sequence variation and functional genomic studies. Cancer Res 68 (12):4791–801. doi:https://doi.org/10.1158/0008-5472.CAN-07-6724.
- Mühl, H. 2013. Pro-inflammatory signaling by IL-10 and IL-22: Bad habit stirred up by interferons? Front. Immunol. 4:18. doi:https://doi.org/10.3389/fimmu.2013.00018.
- Murota, H., M. Izumi, M. I. A. A. El-Latif, M. Nishioka, M. Terao, M. Tani, S. Matsui, S. Sano, and I. Katayama. 2012. Artemin causes hypersensitivity to warm sensation, mimicking warmth-provoked pruritus in atopic dermatitis. J. Allergy Clin. Immunol 130 (3):671–682.e4. doi:https://doi.org/10.1016/j.jaci.2012.05.027.
- Murphey, L. J., J. V. Gainer, D. E. Vaughan, and N. J. Brown. 2000. Angiotensin converting enzyme insertion⁄deletion polymorphism modulates the human in vivo metabolism of bradykinin. Circulation 102 (8):829–32. doi:https://doi.org/10.1161/01.cir.102.8.829.
- Murray, G. I., W. T. Melvin, W. F. Greenlee, and M. D. Burke. 2001. Regulation, function, and tissue -specific expression of cytochrome P450 CYP1B1. Annu. Rev. Pharmacol. Toxicol. 41 (1):297–316. doi:https://doi.org/10.1146/annurev.pharmtox.41.1.297.
- Nakanishi, K., H. Tsutsui, and T. Yoshimoto. 2010. Importance of IL-18-induced super Th1 cells for the development of allergic inflammation. Allergol. Int. 59 (2):137–41. doi:https://doi.org/10.2332/allergolint.10-RAI-0208.
- Nakanishi, K., T. Yoshimoto, H. Okamura, and H. Okamura. 2001. Interleukin −18 regulates both Th1 and Th2 responses. Annu. Rev. Immunol 19 (1):423–74. doi:https://doi.org/10.1146/annurev.immunol.19.1.423.
- Namkung, J. H., J. E. Lee, E. Kim, J. Y. Byun, S. Kim, E. S. Shin, E. Y. Cho, and J. M. Yang. 2010. Hint for association of single nucleotide polymorphisms and haplotype in SPINK5 gene with atopic dermatitis in koreans. Exp. Dermatol 19 (12):1048–53. doi:https://doi.org/10.1111/j.1600-0625.2010.01142.x.
- Napolitano, M., and C. Patruno. 2018. Aryl hydrocarbon receptor (AhR) a possible target for the treatment of skin disease. Med. Hypotheses 116:96–100. doi:https://doi.org/10.1016/j.mehy.2018.05.001.
- Natsch, A., and R. Emter. 2015. Reporter cell lines for skin sensitization testing. Arch. Toxicol 89 (10):1645–68. doi:https://doi.org/10.1007/s00204-015-1555-0.
- Neafsey, P., G. Ginsberg, D. Hattis, and B. Sonawane. 2009a. Genetic polymorphism in cytochrome P450 2D6 (CYP2D6): Population distribution of CYP2D6 activity. J. Toxicol. Environ. Health B 12 (5–6):334–61. doi:https://doi.org/10.1080/10937400903158342.
- Neafsey, P., G. Ginsberg, D. Hattis, D. O. Johns, K. Z. Guyton, and B. Sonawane. 2009b. Genetic polymorphism in CYP2E1: Population distribution of CYP2E1 activity. J. Toxicol. Environ. Health B 12 (5–6):362–88. doi:https://doi.org/10.1080/10937400903158359.
- Nebert, D. W., A. L. Roe, M. Z. Dieter, W. A. Solis, Y. Yang, and T. P. Dalton. 2000. Role of the aromatic hydrocarbon receptor and (Ah) gene battery in the oxidative stress response, cell cycle control, and apoptosis. Biochem. Pharmacol. 59 (1):65–85. doi:https://doi.org/10.1016/S0006-2952(99)00310-X.
- Nedoszytko, B., M. Sokołowska-Wojdyło, K. Ruckemann-Dziurdzińska, J. Roszkiewicz, and R. J. Nowicki. 2014. Chemokines and cytokines network in the pathogenesis of the inflammatory skin diseases: Atopic dermatitis, psoriasis and skin mastocytosis. Derm. Alergol. 2:84–91. doi:https://doi.org/10.5114/pdia.2014.40920.
- Neis, M. M., A. Wendel, T. Wiederholt, Y. Marquardt, S. Joussen, J. M. Baron, and H. F. Merk. 2010. Expression and induction of cytochrome P450 isoenzymes in human skin equivalents. Skin Pharmacol. Physiol 23 (1):29–39. doi:https://doi.org/10.1159/000257261.
- Neis, M. M., B. Peters, A. Dreuw, J. Wenzel, T. Bieber, C. Mauch, T. Krieg, S. Stanzel, P. C. Heinrich, H. F. Merk, et al. 2006. Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis. J. Allergy Clin. Immunol. 118 (4):930–37. doi:https://doi.org/10.1016/j.jaci.2006.07.015.
- Neurath, M. F., and S. Finotto. 2011. IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer. Cytokine Growth Factor Rev 22 (2):83–89. doi:https://doi.org/10.1016/j.cytogfr.2011.02.003.
- Nguyen, A. V., and A. M. Soulika. 2019. The dynamics of the skin’s immune system. Int. J. Mol. Sci. 20 (8):1–53. doi:https://doi.org/10.3390/ijms20081811.
- Niu, X.-L., Y. Huang, Y.-L. Gao, Y.-Z. Sun, Y. Han, H.-D. Chen, X.-H. Gao, and R.-Q. Qi. 2019. Interleukin-18 exacerbates skin inflammation and affects microabscesses and scale formation in a mouse model of imiquimod-induced psoriasis. Chin Med J (Engl) 132 (6):690–98. doi:https://doi.org/10.1097/CM9.0000000000000140.
- Niwa, Y., H. Sumi, K. Kawahira, T. Terashima, T. Nakamura, and H. Akamatsu. 2003. Protein oxidative damage in the stratum corneum: Evidence for a link between environmental oxidants and the changing prevalence and nature of atopic dermatitis in Japan. Br. J. Dermatol. 149 (2):248–54. doi:https://doi.org/10.1046/j.1365-2133.2003.05417.x.
- Nordberg, J., and E. S. J. Arnér. 2001. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radic. Biol. Med. 31 (11):1287–312. doi:https://doi.org/10.1016/S0891-5849(01)00724-9.
- Norlén, L., and A. Al-Amoudi. 2004. Stratum corneum keratin structure, function, and formation: The cubic rod-packing and membrane templating model. J. Invest. Dermatol. 123 (4):715–32. doi:https://doi.org/10.1111/j.0022-202X.2004.23213.x.
- Noti, M., B. S. Kim, M. C. Siracusa, G. D. Rak, M. Kubo, A. E. Moghaddam, Q. A. Sattentau, M. R. Comeau, J. M. Spergel, and D. Artis. 2014. Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin-basophil axis. J. Allergy Clin. Immunol 133 (1390–1399.e6):1390–1399.e6. doi:https://doi.org/10.1016/j.jaci.2014.01.021.
- Novak, N., S. Kruse, J. Potreck, L. Maintz, C. Jenneck, S. Weidinger, R. Fimmers, and T. Bieber. 2005. Single nucleotide polymorphisms of the IL18 gene are associated with atopic eczema. J. Allergy Clin. Immunol 115 (4):828–33. doi:https://doi.org/10.1016/j.jaci.2005.01.030.
- Okamoto, N., M. Okumura, O. Tadokoro, N. Sogawa, M. Tomida, and E. Kondo. 2018. Effect of single-nucleotide polymorphisms in TRPV1 on burning pain and capsaicin sensitivity in Japanese adults. Mol. Pain 14:1744806918804439. doi:https://doi.org/10.1177/1744806918804439.
- Ollier, W., E. Davies, N. Snowden, J. Alldersea, A. Fryer, P. Jones, and R. Strange. 1996. Association of homozygosity for glutathione-s-transferase GSTM1 null alleles with the Ro+/La- autoantibody profile in patients with systemic lupus erythematosus. Arthritis Rheum 39 (10):1763–64. doi:https://doi.org/10.1002/art.1780391023.
- Olszewska, B., M. Sokołowska-Wojdyło, J. Lakomy, and R. Nowicki. 2020. The ambiguous pruritogenic role of interleukin-31 in cutaneous T-cell lymphomas in comparison to atopic dermatitis: A review. Adv. Dermatol. Allergol 37 (3):319–25. doi:https://doi.org/10.5114/ada.2020.96260.
- Omata, N., H. Tsukahara, S. Ito, Y. Ohshima, M. Yasutomi, A. Yamada, M. Jiang, M. Hiraoka, M. Nambu, Y. Deguchi, et al. 2001. Increased oxidative stress in childhood atopic dermatitis. Life Sci 69 (2):223–28. doi:https://doi.org/10.1016/s0024-3205(01)01124-9.
- Omiecinski, C. J., J. P. V. Heuvel, G. H. Perdew, and J. M. Peters. 2011. Xenobiotic metabolism, disposition, and regulation by receptors: From biochemical phenomenon to predictors of major toxicities. Toxicol. Sci 120 (Supplement 1):S49–S75. doi:https://doi.org/10.1093/toxsci/kfq338.
- Orentas, R. J., J. E. Hildreth, E. Obah, M. Polydefkis, G. E. Smith, M. L. Clements, and R. F. Siliciano. 1990. Induction of CD4+Human Cytolytic T Cells Specific for HIV-Infected Cells by a Gp160 Subunit Vaccine. Science 248 (4960):1234–37. doi:https://doi.org/10.1126/science.2190315.
- Osawa, R., M. Akiyama, and H. Shimizu. 2011. Filaggrin gene defects and the risk of developing allergic disorders. Allergol. Int. 60 (1):1–9. doi:https://doi.org/10.2332/allergolint.10-RAI-0270.
- Ott, H., M. A. Bergström, R. Heise, C. Skazik, G. Zwadlo-Klarwasser, H. F. Merk, J. M. Baron, and A. T. Karlberg. 2009. Cutaneous metabolic activation of carvoxime, a self-activating, skin-sensitizing prohapten. Chem. Res. Toxicol. 22 (2):399–405. doi:https://doi.org/10.1021/tx8003642.
- Palmer, C. N. A., A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. D. Smith, et al. 2006. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat. Genet. 38 (4):441–46. doi:https://doi.org/10.1038/ng1767.
- Parrado, C., S. Mercado-Saenz, A. Perez-Davo, Y. Gilaberte, S. Gonzalez, and A. Juarranz. 2019. Environmental stressors on skin aging. Mechanistic insights. Front. Pharmacol 10:1–17. doi:https://doi.org/10.3389/fphar.2019.00759.
- Patel, S. 2018. Danger-associated Molecular Patterns (DAMPs): The derivatives and triggers of inflammation. Curr. Allergy Asthma Rep 18 (11):63. doi:https://doi.org/10.1007/s11882-018-0817-3.
- Pavlovna, K. O., S. N. Sergeevna, L. J. Anatolievna, K. J. Ivanovich, F. M. Leonidovich, K. E. Alexandrovich, G. E. L’vovich, Y. E. Vladimirovna, K. V. Alexandrovich, and S. S. Vitalievich. 2008. Association of single nucleotide polymorphisms in the IL-18 gene with production of IL-18 protein by mononuclear cells from healthy donors. Mediators Inflamm 2008:309721. doi:https://doi.org/10.1155/2008/309721.
- Pearson, W. R., W. R. Vorachek, S. J. Xu, R. Berger, I. Hart, D. Vannais, and D. Patterson. 1993. Identification of class-mu glutathione transferase genes GSTM1-GSTM5 on human chromosome 1p13. Am. J. Human Genet. 53:220–33.
- Pham-Huy, L. A., H. He, and C. Pham-Huy. 2008. Free radicals, antioxidants in disease and health. Int. J. Biomed. Sci. 4 (2):89–96.
- Pietrzak, A., B. Lecewicz-Torun, G. Chodorowska, and J. Rolinski. 2003. Interleukin-18 levels in the plasma of psoriatic patients correlate with the extent of skin lesions and the PASI score. Acta Derm. Venereol. 83 (4):262–65. doi:https://doi.org/10.1080/00015550310016508.
- Poet, T. S., and J. N. McDougal. 2002. Skin absorption and human risk assessment. Chem.-Biol. Interact 140 (1):19–34. doi:https://doi.org/10.1016/S0009-2797(02)00013-3.
- Posadas, S. J., and W. J. Pichler. 2007. Delayed drug hypersensitivity reactions – New concepts. Clin. Exp. Allergy. 37 (7):989–99. doi:https://doi.org/10.1111/j.1365-2222.2007.02742.x.
- Prieto-Pérez, R., T. Cabaleiro, E. Daudén, and F. Abad-Santos. 2013. Gene polymorphisms that can predict response to anti-TNF therapy in patients with psoriasis and related autoimmune diseases. Pharmacogenomics J 13 (4):297–305. doi:https://doi.org/10.1038/tpj.2012.53.
- Prigent, L., M. Robineau, S. Jouneau, C. Morzadec, L. Louarn, L. Vernhet, O. Fardel, and L. Sparfel. 2014. The aryl hydrocarbon receptor is functionally upregulated early in the course of human T-cell activation. Eur J. Immunol 44 (5):1330–40. doi:https://doi.org/10.1002/eji.201343920.
- Puthothu, B., M. Krueger, J. Forster, J. Heinze, M. Weckmann, and A. Heinzmann. 2007. Interleukin (IL)-18 polymorphism 133C/G is associated with severe respiratory syncytial virus infection. Pediatr. Infect. Dis. J. 26 (12):1094–98. doi:https://doi.org/10.1097/INF.0b013e3181453579.
- Quaresma, J. A. S. 2019. Organization of the skin immune system and compartmentalized immune responses in infectious diseases. Clin. Microbiol. Rev. 32 (4):1–35. doi:https://doi.org/10.1128/CMR.00034-18.
- Quentmeier, H., H. G. Drexler, D. Fleckenstein, M. Zaborski, A. Armstrong, J. E. Sims, and S. D. Lyman. 2001. Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading of proliferation. Leukemia 15 (8):1286–92. doi:https://doi.org/10.1038/sj.leu.2402175.
- Quinlan, K. L., I. S. Song, N. W. Bunnett, E. Letran, M. Steinhoff, B. Harten, J. E. Olerud, C. A. Armstrong, S. W. Caughman, and J. C. Ansel. 1998. Neuropeptide regulation of human dermal microvascular endothelial cell ICAM-1 expression and function. Am. J. Physiol. 275 (6):C1580–C1590. doi:https://doi.org/10.1152/ajpcell.1998.275.6.C1580.
- Quintana, F. J., A. S. Basso, A. H. Iglesias, T. Korn, M. F. Farez, E. Bettelli, M. Caccamo, M. Oukka, and H. L. Weiner. 2008. Control of Treg and Th17 cell differentiation by the aryl hydrocarbon receptor. Nature 453 (7191):65–71. doi:https://doi.org/10.1038/nature06880.
- Quinto, R. M., F. Sampogna, L. Fania, D. Ciccone, R. Fusari, S. Mastroeni, L. Lani, and D. Abeni. 2019. Alexithymia, psychological distress, and social impairment in patients with. hidradenitis suppurativa. Dermatology. 237:103–10. doi:https://doi.org/10.1159/000503319.
- Raap, U., D. Wieczorek, M. Gehring, I. Pauls, S. Ständer, A. Kapp, and B. Wedi. 2010. Increased levels of serum IL-31 in chronic spontaneous urticaria. Exp. Dermatol 19 (5):464–66. doi:https://doi.org/10.1111/j.1600-0625.2010.01067.x.
- Raap, U., S. Weißmantel, M. Gehring, A. M. Eisenberg, A. Kapp, and R. Fölster-Holst. 2012. IL-31 significantly correlates with disease activity and Th2 cytokine levels in children with atopic dermatitis. Pediatr. Allergy Immunol. 23 (3):285–88. doi:https://doi.org/10.1111/j.1399-3038.2011.01241.x.
- Racky, J., H. J. Schmitz, H. M. Kauffmann, and D. Schrenk. 2004. Single nucleotide polymorphism analysis and functional characterization of the human ah receptor (AhR) gene promoter. Arch. Biochem. Biophys 421 (1):91–98. doi:https://doi.org/10.1016/j.abb.2003.10.005.
- Rafei-Shamsabadi, D. A., C. S. N. Klose, T. Y. F. Halim, Y. Tanriver, and T. Jakob. 2019. Context dependent role of type 2 innate lymphoid cells in allergic skin inflammation. Front. Immunol 10:2591. doi:https://doi.org/10.3389/fimmu.2019.02591.
- Ramesh, K., S. A. Matta, F. T. Chew, and Y. K. Mok. 2020. Exonic mutations associated with atopic dermatitis disrupt lympho-epithelial Kazal-type related inhibitor action and enhance its degradation. Eur J. Allergy Clin. Immunol. 75 (2):403–11. doi:https://doi.org/10.1111/all.14018.
- Rammensee, H.-G., T. Friede, and S. Stevanović. 1995. MHC ligands and peptide motifs: First listing. Immunogenetics 41 (4):178–228. doi:https://doi.org/10.1007/BF00172063.
- Reich, K., C. Neumann, V. Blaschke, C. Maurer, U. Lippert, C. Neumann, U. Lippert, and C. Neumann. 2001. Response of psoriasis to interleukin-10 is associated with suppression of cutaneous type 1 inflammation, downregulation of the epidermal interleukin-8/CXCR2 pathway and normalization of keratinocyte maturation. J. Invest. Dermatol. 116 (2):319–29. doi:https://doi.org/10.1046/j.1523-1747.2001.01248.x.
- Reich, K., G. Westphal, I. R. König, R. Mössner, P. Schupp, C. Gutgesell, E. Hallier, A. Ziegler, and C. Neumann. 2003. Cytokine gene polymorphisms in atopic dermatitis. Br. J. Dermatol. 148 (6):1237–41. doi:https://doi.org/10.1046/j.1365-2133.2003.05307.x.
- Ren, Z. J., D. H. Cao, P. W. Ren, B. Yang, D. L. Lu, J. Liao, S. Z. Liu, L.-C. Yang, Z.-F. Peng, L.-R. Liu, et al. 2019. Aryl hydrocarbon receptor rs2066853 gene polymorphisms and male infertility risk: A meta-analysis. Renal Fail 41 (1):987–94. doi:https://doi.org/10.1080/0886022X.2019.1673775.
- Rendl, M., J. Ban, P. Mrass, C. Mayer, B. Lengauer, L. Eckhart, W. Declerq, and E. Tschachler. 2002. Caspase-14 expression by epidermal keratinocytes is regulated by retinoids in a differentiation-associated manner. J. Invest. Dermatol. 119 (5):1150–55. doi:https://doi.org/10.1046/j.1523-1747.2002.19532.x.
- Riol-Blanco, L., J. Ordovas-Montanes, M. Perro, E. Naval, A. Thiriot, D. Alvarez, S. Paust, J. N. Wood, and U. H. Von Andrian. 2014. Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation. Nature 510 (7503):157–61. doi:https://doi.org/10.1038/nature13199.
- Robles-Méndez, J. C., P. Rizo-Frías, M. E. Herz-Ruelas, A. G. Pandya, and J. O. Candiani. 2017. Lichen planus pigmentosus and its variants: Review and update. Int. J. Dermatol. 57:505–14. doi:https://doi.org/10.1111/ijd.13806.
- Rochman, Y., M. Kashyap, G. W. Robinson, K. Sakamoto, J. Gomez-Rodriguez, K.-U. Wagner, and W. J. Leonard. 2010. Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling. Proceedings of the National Academy of Sciences 107 (45):19455–60. doi:https://doi.org/10.1073/pnas.1008271107.
- Roers, A., L. Siewe, E. Strittmatter, M. Deckert, D. Schlüter, W. Stenzel, A. D. Gruber, T. Krieg, K. Rajewsky, and W. Müller. 2004. T cell-specific inactivation of the interleukin-10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J. Exp. Med. 200 (10):1289–97. doi:https://doi.org/10.1084/jem.20041789.
- Roosterman, D., T. Goerge, S. W. Schneider, N. W. Bunnett, and M. Steinhoff. 2006. Neuronal control of skin function: The skin as a neuroimmunoendocrine organ. Physiol. Rev. 86 (4):1309–79. doi:https://doi.org/10.1152/physrev.00026.2005.
- Rupec, R. A., S. Boneberger, and T. Ruzicka. 2010. What is really in control of skin immunity: Lymphocytes, dendritic cells, or keratinocytes? Facts and controversies. Clin. Dermatol. 28 (1):62–66. doi:https://doi.org/10.1016/j.clindermatol.2009.04.004.
- Sacco, K. A., and J. D. Milner. 2019. Gene-environment interactions in primary atopic disorders. Curr. Opin. Immunol. 60:148–55. doi:https://doi.org/10.1016/j.coi.2019.06.002.
- Safronova, O. G., V. A. Vavilin, A. A. Lyapunova, S. I. Makarova, V. V. Lyakhovich, L. F. Kaznacheeva, N. A. Manankin, O. A. Batychko, and S. M. Gavalov. 2003. Relationship between glutathione s-transferase P1 polymorphism and bronchial asthma and atopic dermatitis. Bull. Exp. Biol. Med 136 (1):73–75. doi:https://doi.org/10.1023/A:1026001216033.
- Saleem, M. D., E. Oussedik, V. D’Amber, and S. R. Feldman. 2017. Interleukin-31 pathway and its role in atopic dermatitis: A systematic review. J. Dermatol. Treat 28 (7):591–99. doi:https://doi.org/10.1080/09546634.2017.1290205.
- Samuel, J. M., D. Kelberman, A. J. P. Smith, S. E. Humphries, and P. Woo. 2008. Identification of a novel regulatory region in the interleukin-6 gene promoter. Cytokine 42 (2):256–64. doi:https://doi.org/10.1016/j.cyto.2008.02.008.
- Sanders, N. L., and A. Mishra. 2016. Role of interleukin-18 in the pathophysiology of allergic diseases. Cytokine Growth Factor Rev 32:31–39. doi:https://doi.org/10.1016/j.cytogfr.2016.07.001.
- Saunders, S. P., T. Moran, A. Floudas, F. Wurlod, A. Kaszlikowska, M. Salimi, E. M. Quinn, C. J. Oliphant, G. Núñez, R. McManus, et al. 2016. Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity. J. Allergy Clin. Immunol. 137 (2):482–91. doi:https://doi.org/10.1016/j.jaci.2015.06.045.
- Saxena, A., S. Khosraviani, S. Noel, D. Mohan, T. Donner, and A. R. A. Hamad. 2014. Interleukin-10 paradox: A potent immunoregulatory cytokine that has been difficult to harness for immunotherapy. Cytokine 74 (1):27–34. doi:https://doi.org/10.1016/j.cyto.2014.10.031.
- Schaarschmidt, H., D. Ellinghaus, E. Rodríguez, A. Kretschmer, H. Baurecht, S. Lipinski, U. Meyer-Hoffert, J. Harder, W. Lieb, N. Novak, et al. 2015. A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis. J. Allergy Clin. Immunol. 136 (3):802–06. doi:https://doi.org/10.1016/j.jaci.2015.01.047.
- Scheller, J., A. Chalaris, D. Schmidt-Arras, and S. Rose-John. 2011. The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta-Mol. Cell Res 1813 (5):878–88. doi:https://doi.org/10.1016/j.bbamcr.2011.01.034.
- Schnass, W., A. Hüls, A. Vierkötter, U. Krämer, J. Krutmann, and T. Schikowski. 2018. Traffic-related air pollution and eczema in the elderly: Findings from the SALIA cohort. Int. J. Hyg. Environ. Health 221 (6):861–67. doi:https://doi.org/10.1016/j.ijheh.2018.06.002.
- Schnuch, A., and B. C. Carlsen. 2011. Genetics and individual predispositions in contact dermatitis. Contact Dermatitis, Fifth (Berlin, Heidelberg.: Springer), doi: https://doi.org/10.1007/978-3-642-03827-3_2.
- Scholzen, T. E., S. Ständer, H. Riemann, T. Brzoska, and T. A. Luger. 2003. Modulation of cutaneous inflammation by angiotensin-converting enzyme. J. Immunol. 170 (7):3866–73. doi:https://doi.org/10.4049/jimmunol.170.7.3866.
- Scholzen, T. E., and T. A. Luger. 2004. Neutral endopeptidase and angiotensin-converting enzyme - Key enzymes terminating the action of neuroendocrine mediators. Exp. Dermatol 2004 (s4):22–26. doi:https://doi.org/10.1111/j.1600-0625.2004.00260.x.
- Schulz, F., I. Marenholz, R. Fölster-Holst, C. Chen, A. Sternjak, R. Baumgrass, J. Esparza-Gordillo, C. Grüber, R. Nickel, S. Schreiber, et al. 2007. A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema. J. Allergy Clin. Immunol. 120 (5):1097–102. doi:https://doi.org/10.1016/j.jaci.2007.07.065.
- Schurman, S. H., T. P. O’Hanlon, J. A. McGrath, A. Gruzdev, A. Bektas, H. Xu, S. Garantziotis, D. C. Zeldin, and F. W. Miller. 2020. Transethnic associations among immune-mediated diseases and single-nucleotide polymorphisms of the aryl hydrocarbon response gene ARNT and the PTPN22 immune regulatory gene. J. Autoimmun. 107:102363. doi:https://doi.org/10.1016/j.jaut.2019.102363.
- Schwendinger-Schreck, J., S. R. Wilson, and D. M. Bautista. 2015. Interactions between keratinocytes and somatosensory neurons in itch. Handb. Exp. Pharmacol. 226:177–90. doi:https://doi.org/10.1007/978-3-662-44605-8_10.
- Sedimbi, S. K., T. Hägglöf, and M. C. I. Karlsson. 2013. IL-18 in inflammatory and autoimmune disease. Cell. Mol. Life Sci 70 (24):4795–808. doi:https://doi.org/10.1007/s00018-013-1425-y.
- Settin, A. A., H. A. Hassan, R. A. El-Baz, and T. A. Hassan. 2009. Association of cytokine gene polymorphisms with psoriasis in cases from the Nile delta of Egypt. Indian J. Dermatol. 18:105–12. doi:https://doi.org/10.4103/0019-5154.82479.
- Sezer, E., F. Ozugurlu, H. Ozyurt, S. Sahin, and I. Etikan. 2007. Lipid peroxidation and antioxidant status in lichen planus. Clin. Exp. Dermatol. 32 (4):430–34. doi:https://doi.org/10.1111/j.1365-2230.2007.02436.x.
- Shapiro, M., A. C. Sosis, J. M. Junkins-Hopkins, and V. P. Werth. 2004. Lupus erythematosus induced by medications, ultraviolet radiation, and other exogenous agents: A review, with special focus on the development of subacute cutaneous lupus erythematosus in a genetically predisposed individual. Int. J. Dermatol. 43 (2):87–94. doi:https://doi.org/10.1111/j.1365-4632.2004.02013.x.
- Sharif, M. N., I. Tassiulas, Y. Hu, I. Mecklenbräuker, A. Tarakhovsky, and L. B. Ivashkiv. 2004. IFN-α priming results in a gain of proinflammatory function by IL-10: Implications for systemic lupus erythematosus pathogenesis. J. Immunol. 172 (10):6476–81. doi:https://doi.org/10.4049/jimmunol.172.10.6476.
- Sheehan, D., G. Meade, M. V. Foley, and A. C. Dowd. 2001. Structure, function and evolution of glutathione transferases: Implications for classification of non-mammalian members of an ancient enzyme superfamily. J. Biochem 360 (1):1–16. doi:https://doi.org/10.1057/9781137378699_11.
- Shimada, T., and Y. Fujii-Kuriyama. 2004. Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1. Cancer Sci 52:109–24. doi:https://doi.org/10.1111/j.1349-7006.2004.tb03162.x.
- Shimoura, N., H. Nagai, S. Fujiwara, H. Jimbo, T. Yoshimoto, and C. Nishigori. 2017. Interleukin (IL)-18, cooperatively with IL-23, induces prominent inflammation and enhances psoriasis-like epidermal hyperplasia. Arch. Dermatol. Res 309 (4):315–21. doi:https://doi.org/10.1007/s00403-017-1735-2.
- Singh, B., A. G. Jegga, K. S. Shanmukhappa, R. Edukulla, G. H. Khurana, M. Medvedovic, S. R. Dillon, S. K. Madala, and M. Simon. 2016. IL-31-driven skin remodeling involves epidermal cell proliferation and thickening that lead to impaired skin-barrier function. PLoS ONE 11 (8):1–15. doi:https://doi.org/10.1371/journal.pone.0161877.
- Smart, J., and A. K. Daly. 2000. Variation in induced CYP1A1 levels: Relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. Pharmacogenetics 10 (1):11–24. doi:https://doi.org/10.1097/00008571-200002000-00003.
- Soga, M., A. Matsuzawa, and H. Ichijo. 2012. Oxidative stress-induced diseases via the ASK1 signaling pathway. Int. J. Cell Biol. 2012. doi:https://doi.org/10.1155/2012/439587.
- Sohn, M. H., J. S. Song, K. W. Kim, E. S. Kim, K. E. Kim, and J. M. Lee. 2007. Association of interleukin-10 gene promoter polymorphism in children with atopic dermatitis. J. Pediatr. 150 (1):106–08. doi:https://doi.org/10.1016/j.jpeds.2006.08.065.
- Sokołowska-Wojdyło, M., J. Gleń, M. Zabłotna, K. Rȩbała, M. Sikorska, A. Florek, M. Trzeciak, W. Barańska-Rybak, M. Malek, and B. Nedoszytko. 2012. Association of distinct IL-31 polymorphisms with pruritus and severity of atopic dermatitis. J. Eur. Acad. Dermatol. Venereol. 27 (5):662–64. doi:https://doi.org/10.1111/j.1468-3083.2012.04649.x.
- Song, G. G., S. C. Bae, J. H. Kim, and Y. H. Lee. 2015. The angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to rheumatoid arthritis, vitiligo and psoriasis: A meta-analysis. Renin. Angiotensin Aldosterone Syst 16 (1):195–202. doi:https://doi.org/10.1177/1470320313478285.
- Sonkoly, E., A. Muller, A. I. Lauerma, A. Pivarcsi, H. Soto, L. Kemeny, H. Alenius, M.-C. Dieu-Nosjean, S. Meller, J. Rieker, et al. 2006. IL-31: A new link between T cells and pruritus in atopic skin inflammation. J. Allergy Clin. Immunol. 117 (2):411–17. doi:https://doi.org/10.1016/j.jaci.2005.10.033.
- Sontheimer, R. D. 1989. Subacute cutaneous lupus erythematosus: A decade’s perspective. Med. Clin. North Am. 73 (5):1073–90. doi:https://doi.org/10.1016/S0025-7125(16)30620-4.
- Sorg, O. 2014. AhR signalling and dioxin toxicity. Toxicol. Lett 230 (2):225–33. doi:https://doi.org/10.1016/j.toxlet.2013.10.039.
- Sorour, N. E., A. I. Mustafa, N. F. Alhusseni, E. Fawzy, and A. G. Amer. 2019. Angiotensin-converting enzyme gene insertion/deletion polymorphism and family history in severe acne vulgaris. J. Cosmet. Dermatol. 18 (6):1992–97. doi:https://doi.org/10.1111/jocd.12937.
- Spencer, L. A., C. T. Szela, S. A. Perez, C. L. Kirchhoffer, J. S. Neves, A. L. Radke, and P. F. Weller. 2009. Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentially. J. Leukoc. Biol 85 (1):117–23. doi:https://doi.org/10.1189/jlb.0108058.
- Spergel, J. M., A. S. Paller, and A. S. Paller. 2003. Atopic dermatitis and the atopic march. J. Allergy Clin. Immunol. 112 (6):118–27. doi:https://doi.org/10.1016/j.jaci.2003.09.033.
- Stavric, K., S. Peova, D. Trajkov, and M. Spiroski. 2012. Gene polymorphisms of 22 cytokines in Macedonian children with atopic dermatitis. Iran. J. Allergy Asthma Immunol. 11 (1):37–50.
- Steinhoff, M., J. Bienenstock, M. Schmelz, M. Maurer, E. Wei, and T. Bíró. 2006. Neurophysiological, neuroimmunological, and neuroendocrine basis of pruritus. J. Invest. Dermatol. 126 (8):1705–18. doi:https://doi.org/10.1038/sj.jid.5700231.
- Strange, R. C., P. W. Jones, and A. A. Fryer. 2000. Gluathione s-transferase: Genetics and role in toxicology. Toxicol. Lett. 112–113:357–63. doi:https://doi.org/10.1016/S0378-4274(99)00230-1.
- Sun, L. D., F. L. Xiao, Y. Li, W. M. Zhou, H. Y. Tang, X. F. Tang, H. Zhang, H. Schaarschmidt, X.-B. Zuo, R. Foelster-Holst, et al. 2011. Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population. Nat. Genet. 43 (7):690–94. doi:https://doi.org/10.1038/ng.851.
- Sun, L., X. Wang, Y. Zhang, T. Wang, X. Li, and Y. Ma. 2016. The evaluation of neural and vascular hyper-reactivity for sensitive skin. Skin Res. Technol 22 (3):381–87. doi:https://doi.org/10.1111/srt.12278.
- Tabas, I., and C. K. Glass. 2013. Anti-inflammatory therapy in chronic disease: Challenges and opportunities. Science 339 (6116):166–72. doi:https://doi.org/10.1126/science.1230720.
- Takahashi, H., H. Tsuji, Y. Hashimoto, A. Ishida-Yamamoto, and H. Iizuka. 2010. Serum cytokines and growth factor levels in Japanese patients with psoriasis. Clin. Exp. Dermatol. 35 (6):645–49. doi:https://doi.org/10.1111/j.1365-2230.2009.03704.x.
- Takahashi, N., D. Kozai, and Y. Mori. 2012. TRP channels: Sensors and transducers of gastrotransmitter signals. Front. Physiol. 3:324. doi:https://doi.org/10.3389/fphys.2012.00324.
- Tan, N. Y., and L. M. Khachigian. 2009. Sp1 phosphorylation and its regulation of gene transcription. Mol. Cell. Biol 29 (10):2483–88. doi:https://doi.org/10.1128/mcb.01828-08.
- Tanaka, T., H. Tsutsui, T. Yoshimoto, M. Kotani, M. Matsumoto, A. Fujita, W. Wang, S. Higa, T. Koshimoto, K. Nakanishi, et al. 2001. Interleukin-18 is elevated in the sera from patients with atopic dermatitis and from atopic dermatitis model mice, NC/Nga. Int. Arch. Allergy Immunol. 125 (3):236–40. doi:https://doi.org/10.1159/000053821.
- Tas, B., and S. Altinay. 2014. Toluene induced exanthematous lichen planus: Report of two cases. Global Dermatol 7. doi:https://doi.org/10.15761/GOD.1000110.
- Tauchi, M., A. Hida, T. Negishi, F. Katsuoka, S. Noda, J. Mimura, T. Hosoya, A. Yanaka, H. Aburatani, Y. Fujii-Kuriyama, et al. 2005. Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions. Mol. Cell. Biol 25 (21):9360–68. doi:https://doi.org/10.1128/mcb.25.21.9360-9368.2005.
- Tavakolpour, S. 2018. Pemphigus trigger factors: Special focus on pemphigus vulgaris and pemphigus foliaceus. Arch. Dermatol. Res 310 (2):95–106. doi:https://doi.org/10.1007/s00403-017-1790-8.
- Tay, S. S., B. Roediger, P. L. Tong, S. Tikoo, and W. Weninger. 2014. The skin-resident immune network. Curr. Dermatol. Rep. 3 (1):13–22. doi:https://doi.org/10.1007/s13671-013-0063-9.
- Teodoro, M., G. Briguglio, C. Fenga, and C. Costa. 2019. Genetic polymorphisms as determinants of pesticide toxicity: Recent advances. Toxicol. Rep. 6:564–70. doi:https://doi.org/10.1016/j.toxrep.2019.06.004.
- Terry, C. F., V. Loukaci, and F. R. Green. 2000. Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J. Biol. Chem. 275 (24):18138–44. doi:https://doi.org/10.1074/jbc.M000379200.
- Tete, S., D. Tripodi, M. Rosati, F. Conti, G. Maccauro, A. Saggini, V. Salini, E. Cianchetti, A. Caraffa, P. Antinolfi, et al. 2012. Role of mast cells in innate and adaptive immunity. J. Biol. Regul. Homeost. Agents 26 (2):193–201.
- Tippisetty, S., M. Ishaq, P. L. Komaravalli, and P. Jahan. 2011. Angiotensin converting enzyme (ACE) gene polymorphism in vitiligo: Protective and predisposing effects of genotypes in disease susceptibility and progression. Eur. J. Dermatol. 21 (2):173–77. doi:https://doi.org/10.1684/ejd.2011.1279.
- To-Figueras, J., M. Gené, J. Gómez-Catalán, E. Piqué, N. Borrego, G. Marfany, R. Gonzalez-Duarte, and J. Corbella. 2000. Polymorphism of glutathione s-transferase M3: Interaction with glutathione s-transferase Mi and lung cancer susceptibility. Biomarkers 5 (1):73–80. doi:https://doi.org/10.1080/135475000230550.
- Tordeurs, D., F. Poot, P. Janne, C. Reynaert, and V. Salamon. 2001. Psychological approach to different skin diseases: Life events and tendency to complain. Ann. Dermatol. Venereol 128 (1):21–24.
- Trier, A. M., M. R. Mack, and B. S. Kim. 2019. The neuroimmune axis in skin sensation, inflammation, and immunity. J. Immunol. 202 (10):2829–35. doi:https://doi.org/10.4049/jimmunol.1801473.
- Trzeciak, M., J. Gleń, J. Roszkiewicz, and B. Nedoszytko. 2010. Association of single nucleotide polymorphism of interleukin-18 with atopic dermatitis. J. Eur. Acad. Dermatol. Venereol. 24 (1):78–79. doi:https://doi.org/10.1111/j.1468-3083.2009.03272.x.
- Tsuji, G., M. Takahara, H. Uchi, T. Matsuda, T. Chiba, S. Takeuchi, F. Yasukawa, Y. Moroi, and M. Furue. 2012. Identification of ketoconazole as an AhR-Nrf2 activator in cultured human keratinocytes: The basis of its anti-inflammatory effect. J. Invest. Dermatol. 132 (1):59–68. doi:https://doi.org/10.1038/jid.2011.194.
- Tsuji, R. F., M. Szczepanik, I. Kawikova, V. Paliwal, R. A. Campos, A. Itakura, M. Akahira-Azuma, N. Baumgarth, L. A. Herzenberg, and P. W. Askenase. 2002. B cell-dependent T cell responses: IgM antibodies are required to elicit contact sensitivity. J. Exp. Med. 196 (10):1277–90. doi:https://doi.org/10.1084/jem.20020649.
- Tsukahara, H., R. Shibata, Y. Ohshima, Y. Todoroki, S. Sato, N. Ohta, M. Hiraoka, A. Yoshida, S. Nishima, and M. Mayumi. 2003. Oxidative stress and altered antioxidant defenses in children with acute exacerbation of atopic dermatitis. Life Sci 72 (22):2509–16. doi:https://doi.org/10.1016/s0024-3205(03)00145-0.
- Turner, D. M., D. M. Williams, D. Sankaran, M. Lazarus, P. J. Sinnott, and I. V. Hutchinson. 1997. An investigation of polymorphism in the interleukin-10 gene promoter. Eur. J. Immunol. 24 (1):1–8. doi:https://doi.org/10.1111/j.1365-2370.1997.tb00001.x.
- Uzzaman, A., and H. C. Seong. 2012. Classification of hypersensitivity reactions. Allergy Asthma Proc 33 (3):S96–S99. doi:https://doi.org/10.2500/aap.2012.33.3561.
- Valdimarsson, H., B. S. Baker, I. Jonsdottir, and L. Fry. 1986. Psoriasis: A disease of abnormal keratinocyte proliferation induced by T-lymphocytes. Immunol. Today 7 (9):256–59. doi:https://doi.org/10.1016/0167-5699(86)90005-8.
- Van Den Bogaard, E. H., J. G. M. Bergboer, M. Vonk-Bergers, I. M. J. J. V. Vlijmen-Willems, S. V. Hato, P. G. M. V. D. Valk, J. M. Schröder, I. Joosten, P. L. J. M. Zeeuwen, and J. Schalkwijk. 2013. Coal tar induces AhR-dependent skin barrier repair in atopic dermatitis. J. Clin. Invest. 123 (2):917–27. doi:https://doi.org/10.1172/JCI65642.
- Van Den Bogaard, E. H., M. A. Podolsky, J. P. Smits, X. Cui, C. John, K. Gowda, D. Desai, S. G. Amin, J. Schalkwijk, G. H. Perdew, et al. 2015. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation. J. Invest. Dermatol. 135 (5):1320–28. doi:https://doi.org/10.1038/jid.2015.6.
- Victor, F. C., and A. B. Gottlieb. 2002. TNF-alpha and apoptosis: Implications for the pathogenesis and treatment of psoriasis. J. Drugs Dermatol 1 (3):264–75.
- Vogel, C. F. A., E. M. Khan, P. S. C. Leung, M. E. Gershwin, W. L. W. Chang, D. Wu, T. Haarmann-Stemmann, A. Hoffmann, and M. S. Denison. 2014. Cross-talk between aryl hydrocarbon receptor and the inflammatory response: A role for nuclear factor-κb. J. Biol. Chem. 289 (3):1866–75. doi:https://doi.org/10.1074/jbc.M113.505578.
- Vogel, C. F. A., L. S. Van Winkle, C. Esser, and T. Haarmann-Stemmann. 2020. The aryl hydrocarbon receptor as a target of environmental stressors – Implications for pollution mediated stress and inflammatory responses. Redox Biol 34:101530. doi:https://doi.org/10.1016/j.redox.2020.101530.
- Wakem, P., R. P. Burns Jr, F. Ramirez, D. Zlotnick, B. Ferbel, C. G. Haidaris, and A. A. Gaspari. 2000. Allergens and irritants transcriptionally upregulate CD80 gene expression in human keratinocytes. J. Invest. Dermatol 114 (6):1085–92. doi:https://doi.org/10.1046/j.1523-1747.2000.00997.x.
- Walley, A. J., S. Chavanas, M. F. Moffatt, R. M. Esnouf, B. Ubhi, R. Lawrence, K. Wong, G. R. Abecasis, E. Y. Jones, J. I. Harper, et al. 2001. Gene polymorphism in netherton and common atopic disease. Nat. Genet. 29 (2):175–78. doi:https://doi.org/10.1038/ng728.
- Walsh, A. A., G. D. Szklarz, and E. E. Scott. 2013. Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism. J. Biol. Chem. 288 (18):12932–43. doi:https://doi.org/10.1074/jbc.M113.452953.
- Wang, B., J. S. Shiao, C. J. Chen, Y. C. Lee, and Y. L. Guo. 2007. Tumour necrotizing factor-α promoter and GST-T1 genotype predict skin allergy to chromate in cement workers in Taiwan. Contact Dermatitis 57 (5):309–15. doi:https://doi.org/10.1111/j.1600-0536.2007.01242.x.
- Wang, I. J., L. S. H. Wu, G. A. Lockett, and W. J. J. Karmaus. 2016. TSLP polymorphisms, allergen exposures, and the risk of atopic disorders in children. Ann. Allergy Asthma Immunol 116 (2):139–45. doi:https://doi.org/10.1016/j.anai.2015.11.016.
- Wang, L. L., Y. Li, and S. F. Zhou. 2009. A bioinformatics approach for the phenotype prediction of nonsynonymous single nucleotide polymorphisms in human cytochromes P450E. Drug Metab. Dispos. 37 (5):977–91. doi:https://doi.org/10.1124/dmd.108.026047.
- Wang, L., and H. Zhou. 2019. A meta-analysis of the relationship between tumor necrosis factor-α polymorphisms and psoriasis. Dermatology 237 (1):39–45. doi:https://doi.org/10.1159/000502255.
- Wang, W., T. Tanaka, H. Okamura, M. Sugita, S. Higa, T. Kishimoto, and M. Suemura. 2001. Interleukin-18 enhances the production of interleukin-8 by eosinophils. Eur. J. Immunol. 31 (4):1010–16. doi:https://doi.org/10.1002/1521-4141(200104)31:4<1010::AID-IMMU1010>3.0.CO;2-8.
- Wang, X.-W., K. Li, S. Guo, H. N. Qiang, L. Liu, P. Song, C. Wei, X.-L. Yi, Z. Jian, Q. Li, et al. 2012. The association of functional polymorphisms in the aryl hydrocarbon receptor (AHR) gene with the risk of vitiligo in Han Chinese populations. Br. J. Dermatol. 166 (5):1081–87. doi:https://doi.org/10.1111/j.1365-2133.2011.10798.x.
- Wang, X., K. Li, L. Liu, Q. Shi, P. Song, Z. Jian, S. Guo, G. Wang, C. Li, and T. Gao. 2015. AHR promoter variant modulates its transcription and downstream effectors by allele-specific AHR-SP1 interaction functioning as a genetic marker for vitiligo. Sci. Rep. 5:1–11. doi:https://doi.org/10.1038/srep13542.
- Wang, Y., S. Li, and C. Li. 2019. Perspectives of new advances in the pathogenesis of vitiligo: From oxidative stress to autoimmunity. Med Sci. Monit. 25:1017–23. doi:https://doi.org/10.12659/MSM.914898.
- Wastowski, I. J., N. T. A. Peres, R. T. Simões, E. C. Castelli, A. L. Simões, N. M. Martinez-Rossi, and E. A. Donadi. 2006. Identification of a novel 120 Bp Allele at the TNFd microsatellite locus. Tissue Antigens 67 (4):318–20. doi:https://doi.org/10.1111/j.1399-0039.2006.00565.x.
- Webb, G., V. Vaska, M. Coggan, and P. Board. 1996. Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1). Genomics 33 (1):121–23. doi:https://doi.org/10.1006/geno.1996.0167.
- Weger, W., A. Hofer, P. Wolf, Y. El-Shabrawi, W. Renner, H. Kerl, and W. Salmhofer 1. 2007. The angiotensin-converting enzyme insertion⁄deletion and the endothelin −134 3A⁄4A gene polymorphisms in patients with chronic plaque psoriasis. Exp. Dermatol 16 (12):993–98. doi:https://doi.org/10.1111/j.1600-0625.2007.00620.x.
- Westphal, G. A., A. Schnuch, R. Moessner, I. R. König, B. Kränke, E. Hallier, A. Ziegler, and K. Reich. 2003. Cytokine gene polymorphisms in allergic contact dermatitis. Contact Dermatitis 48 (2):93–98. doi:https://doi.org/10.1034/j.1600-0536.2003.480208.x.
- Wilson, A. G., J. A. Symons, T. L. Mcdowell, H. O. Mcdevitt, and G. W. Duff. 1997. Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation. Proc. Natl. Acad. Sci. U.S.A. 94 (7):3195–99. doi:https://doi.org/10.1073/pnas.94.7.3195.
- Wincent, E., N. Amini, S. Luecke, H. Glatt, J. Bergman, C. Crescenzi, A. Rannug, and U. Rannug. 2009. The suggested physiologic aryl hydrocarbon receptor activator and cytochrome p4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. J. Biol. Chem. 284 (5):2690–96. doi:https://doi.org/10.1074/jbc.M808321200.
- Wong, C. K., S. Hu, P. F. Y. Cheung, and C. W. K. Lam. 2010. Thymic stromal lymphopoietin induces chemotactic and prosurvival effects in eosinophils: Implications in allergic inflammation. Am. J. Respir. Cell Mol. Biol 43 (3):305–15. doi:https://doi.org/10.1165/rcmb.2009-0168oc.
- Wongpiyabovorn, J., N. Hirankarn, K. Ruchusatsawat, S. Yooyongsatit, P. Asawanonda, and Y. Poovorawan. 2008. association of the interleukin-10 distal promoter (−2763A/C) polymorphism with late-onset psoriasis. Clin. Exp. Dermatol. 33 (2):186–89. doi:https://doi.org/10.1111/j.1365-2230.2007.02628.x.
- Wright, A. F. 2005. Genetic variation: Polymorphisms and mutations. Encyclopedia Life Sci. doi:https://doi.org/10.1038/npg.els.0005005.
- Xue, L., M. Salimi, I. Panse, J. M. Mjösberg, A. N. J. McKenzie, H. Spits, P. Klenerman, and G. Ogg. 2014. Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on Th2 cells. J. Allergy Clin. Immunol 133 (4):1184–1194.e7. doi:https://doi.org/10.1016/j.jaci.2013.10.056.
- Yamamoto, T. 2008. Scleroderma pathophysiology. Eur. J. Dermatol. 19 (1):14–24. doi:https://doi.org/10.1684/ejd.2008.0570.
- Yanaba, K., M. Kamata, N. Ishiura, S. Shibata, Y. Asano, Y. Tada, M. Sugaya, T. Kadono, T. F. Tedder, and S. Sato. 2013. Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation. J. Leukoc. Biol 94 (4):563–73. doi:https://doi.org/10.1189/jlb.1112562.
- Yanez, D. A., R. K. Lacher, A. Vidyarthi, and O. R. Colegio. 2017. The role of macrophages in skin homeostasis. Pflugers Arch 469 (3–4):455–63. doi:https://doi.org/10.1007/s00424-017-1953-7.
- Yang, K., F. Zhang, F. Li, J. Su, S. Wen, Y. Liu, and D. Feng. 2013. Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to psoriasis in a Chinese population. J. Renin. Angiotensin Aldosterone Syst 15 (1):39–43. doi:https://doi.org/10.1177/1470320313494433.
- Yang, Y., Q. Wang, X. Song, W. Jiang, S. Tang, F. Shen, and S. Xie. 2017. Association between IL-4, IL-6, IL-18 polymorphisms and atopic dermatitis risk: A meta-analysis. Int. J. Clin. Exp. Med. 10:7375–86.
- Yasukawa, K., T. Hirano, Y. Watanabe, K. Muratani, T. Matsuda, S. Nakai, and T. Kishimoto. 1987. Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) Gene. EMBO J 6 (10):2939–45. doi:https://doi.org/10.1002/j.1460-2075.1987.tb02598.x.
- Yoshimoto, T., H. Mizutani, H. Tsutsui, N. Noben-Trauth, K.-I. Yamanaka, M. Tanaka, S. Izumi, H. Okamura, W. E. Paul, and K. Nakanishi. 2000. IL-18 Induction of IgE: Dependence on CD4+ T cells, IL-4 and STAT6. Nat. Immunol 1 (2):132–37. doi:https://doi.org/10.1038/77811.
- Yoshimoto, T., H. Tsutsui, K. Tominaga, K. Hoshino, H. Okamura, S. Akira, W. E. Paul, and K. Nakanishi. 1999. IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils. Proc. Natl. Acad. Sci. U.S.A. 96 (24):13962–66. doi:https://doi.org/10.1073/pnas.96.24.13962.
- Yucesoy, B., Y. Talzhanov, M. M. Barmada, V. J. Johnson, M. L. Kashon, E. Baron, N. W. Wilson, B. Frye, W. Wang, K. Fluharty, et al. 2016. Association of MHC region SNPs with irritant susceptibility in healthcare workers. J. Immunotoxicol. 13 (5):738–44. doi:https://doi.org/10.3109/1547691X.2016.1173135.
- Zabrodsky, P. F. 2019. Overview of immunology and allergy. J. Immunol Allergy 1:1–5. doi:https://doi.org/10.1007/978-3-319-58726-4_1-1.
- Zanger, U. M., and M. Schwab. 2013. Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol. Ther. 138 (1):103–41. doi:https://doi.org/10.1016/j.pharmthera.2012.12.007.
- Zhang, H., Y. Park, J. Wu, X. P. Chen, S. Lee, J. Yang, K. C. Dellsperger, and C. Zhang. 2009. Role of TNF-α in vascular dysfunction. Clin. Sci. 116 (3):219–30. doi:https://doi.org/10.1042/CS20080196.
- Zhang, J.-M., and J. An. 2007. Cytokines, inflammation, and pain. Int. Anesthesiol. Clin 45 (2):27–37. doi:https://doi.org/10.1097/AIA.0b013e318034194e.
- Zhao, J., Z. Y. Chen, and L. F. Li. 2019. Association Between the IL-10-1082G/A, IL-10-592A/C, and IL-10-819G/A Polymorphisms and Atopic Dermatitis Susceptibility: A Meta-Analysis. Genet. Test. Mol. Biomark 23 (5):332–41. doi:https://doi.org/10.1089/gtmb.2018.0276.
- Zhou, L. 2016. AHR function in lymphocytes: Emerging concepts. Trends Microbiol 37:17–31. doi:https://doi.org/10.1016/j.it.2015.11.007.
- Zhou, S. F., J. P. Liu, and B. Chowbay. 2009. Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metab. Rev. 41 (2):89–295. doi:https://doi.org/10.1080/03602530902843483.
- Ziegler, S. F., and D. Artis. 2010. Sensing the outside world: TSLP regulates barrier immunity. Nat. Immunol. 11 (4):289–93. doi:https://doi.org/10.1038/ni.1852.