Developmental and reproductive toxicity of inorganic arsenic: Animal studies and human concerns

References

• Aschengrau , A. , Zierler , S. and Cohen , A. 1989 . Quality of community drinking water and the occurrence of spontaneous abortion . Arch Environ Health , 44 : 283 – 290 .
   PubMed Web of Science ®Google Scholar
• Barlow , S. M. and Sullivan , F. M. 1982 . Reproductive hazards of industrial chemicals , London : Academic Press .
   Google Scholar
• Baxley , M. N. , Hood , R. D. , Vedel , G. C. , Harrison , W. P. and Szczech , C. M. 1981 . Prenatal toxicity of orally administered sodium arsenite in mice . Bull. Environ. Contam. Toxicol. , 26 : 749 – 756 .
   PubMed Web of Science ®Google Scholar
• Beaudoin , A. R. 1974 . Teratogenicity of sodium arsenate in rats . Teratology , 10 : 153 – 158 .
   PubMedGoogle Scholar
• Beaudoin , A. R. and Fisher , D. L. 1981 . An in vivo/in vitro evaluation of teratogenic action . Teratology , 23 : 57 – 61 .
   PubMedGoogle Scholar
• Beckman , L. 1978 . The Ronnskar smelter—Occupational and environmental effects in and around a polluting industry in northern Sweden . Ambio , 7 : 226 – 231 .
   Web of Science ®Google Scholar
• Bencko , V. , Nejedly , K. and Somora , J. 1968 . Histological picture of several organs after long‐term peroral administration of arsenic to hairless mice . Cesk. Hyg. , 13 : 344 – 347 .
   Google Scholar
• Blanusa , M. , Maljkovic , T. and Kostial , K. 1988 . Reproductive toxicological effects in rats after oral exposure to effluents from a coal gasification plant . Arh. Hig. Rad. Toksikol. , 39 : 9 – 21 .
   PubMedGoogle Scholar
• Bogdan , G. M. , Sampayo‐Reyes , A. and Aposhian , H. V. 1994 . Arsenic binding proteins of mammalian systems: I. Isolation of three arsenite‐binding proteins of rabbit liver . Toxicology , 93 : 175 – 193 .
   PubMedGoogle Scholar
• Bollinger , C. T. , Van Zijl , P. and Louw , J. A. 1992 . Multiple organ failure with the adult respiratory distress syndrome in homicidal arsenic poisoning . Respiration , 59 : 57 – 61 .
   PubMedGoogle Scholar
• Borzsonyi , M. , Bereczky , A. , Rudnai , P. , Csanady , M. and Horvath , A. 1992 . Epidemiological studies on human subjects exposed to arsenic in drinking water in Southeast Hungary . Arch. Toxicol. , 66 : 77 – 78 .
   PubMed Web of Science ®Google Scholar
• Buchet , J. P. , Lauwerys , R. and Roels , H. 1981 . Comparison of the urinary excretion of arsenic metabolites after a single oral dose of sodium arsenite, monomethylarsonate, or dimethylarsi‐nate in man . Int. Arch. Occup. Environ. Health , 48 : 71 – 79 .
   PubMed Web of Science ®Google Scholar
• Buchet , J. P. , Pauwels , J. and Lauwerys , R. 1994 . Assessment of exposure to inorganic arsenic following ingestion of marine organisms by volunteers . Environ. Res. , 66 : 44 – 51 .
   PubMed Web of Science ®Google Scholar
• Burk , D. and Beaudoin , A. R. 1977 . Arsenate‐induced renal agenesis in rats . Teratology , 16 : 247 – 260 .
   PubMedGoogle Scholar
• Byron , W. R. , Bierbower , C. W. , Brouwer , J. B. and Hansen , W. H. 1967 . Pathologic changes in rats and dogs from two‐year feeding of sodium arsenite or sodium arsenate . Toxicol. Appl. Pharmacol. , 10 : 132 – 147 .
   PubMedGoogle Scholar
• Carpenter , S. J. 1987 . Developmental analysis of cephalic axial dysraphic disorders in arsenic‐treated hamster embryos . Anat. Embryol. , 176 : 345 – 365 .
   PubMedGoogle Scholar
• Cebrian , M. E. , Albores , A. , Carcia‐Vargas , C. , Del Razo , L. M. and Ostosky‐Wegman , P. 1994 . “ Chronic arsenic poisoning in humans: The case of Mexico ” . In Advances in environmental science and technology. Arsenic in the environment, Part II: Human health and ecosystem effects , Edited by: Nriagu , J. O. 93 – 107 . New York : John Wiley & Sons .
   Google Scholar
• Chaineau , E. , Binet , S. , Pol , D. , Chatellier , G. and Meininger , V. 1990 . Embryotoxic effects of sodium arsenite and sodium arsenate on mouse embryos in culture . Teratology , 41 : 105 – 112 .
   PubMedGoogle Scholar
• Chen , C. J. , Chiou , H. Y. , Chiang , M. H. , Lin , L. J. and Tai , T. Y. 1996 . Dose‐response relationship between ischemic heart disease mortality and long‐term arsenic exposure . Arteriosclerosis Thromb. Vase. Biol. , 4 : 504 – 510 .
   Google Scholar
• Chen , C. L. and Whanger , P. D. 1994 . Interaction of selenium and arsenic with metallothionein: Effect of vitamin B12 . J. Inorg. Biochem. , 54 : 267 – 276 .
   PubMedGoogle Scholar
• Daniellson , B. R. G. , Dencker , L. and Tjalve , H. 1984 . Accumulation of toxic metals in male reproductive organs . Arch. Toxicol. , 7 : 177 – 180 .
   Google Scholar
• Davis , A. , Ruby , M. V. and Bergstrom , P. D. 1992 . Bioavailability of arsenic and lead in soils from the Butte, Montana, Mining District . Environ. Sci. Technol. , 26 : 461 – 468 .
   Web of Science ®Google Scholar
• Daya , M. R. , Irwin , R. , Parshley , M. C. , Harding , J. and Burton , B. T. 1989 . Arsenic ingestion in pregnancy . Vet. Hum. Toxicol. , 31 : 347
   Google Scholar
• De Kimpe , J. , Cornelis , R. , Mees , L. and Vanholder , R. 1996 . Basal metabolism of intraperitoneally injected carrier‐free 74As‐labeled arsenate in rabbits . Fundam. Appl. Toxicol. , 34 : 240 – 248 .
   PubMedGoogle Scholar
• Deknudt , G. , Leonard , A. , Arany , J. , Jenar‐Du Buisson , G. and Delavignette , E. 1986 . In vivo studies in male mice on the mutagenic effects of inorganic arsenic . Mutagenesis , 1 : 33 – 34 .
   PubMed Web of Science ®Google Scholar
• Delnomdedieu , M. , Basti , M. M. , Otvos , J. D. and Thomas , D. J. 1994 . Reduction and binding of arsenate and dimethylarsinate by glutathione: A magnetic resonance study . Chem. Biol. Interact. , 90 : 139 – 155 .
   PubMed Web of Science ®Google Scholar
• Domingo , J. L. 1994 . Metal‐induced developmental toxicity in mammals: A review . J. Toxicol. Environ. Health , 42 : 123 – 141 .
   PubMed Web of Science ®Google Scholar
• Domingo , J. L. 1996 . “ Developmental and reproductive effects of metal chelators ” . In Toxicology of metals , Edited by: Chang , L. W. , Suzuki , T. and Magos , L. 1153 – 1167 . Boca Raton, FL : Lewis .
   Google Scholar
• Domingo , J. L. , Bosque , M. A. and Piera , V. 1991 . Meso‐2,3‐dimercaptosuccinic acid and prevention of arsenite embryotoxicity and teratogenicity in the mouse . Fundam. Appl. Toxicol. , 17 : 314 – 320 .
   PubMedGoogle Scholar
• Domingo , J. L. , Bosque , M. A. , Llobet , J. M. and Corbella , J. 1992 . Amelioration by BAL (2,3‐dimer‐capto‐1‐propanol) and DMPS (sodium 2,3‐dimercapto‐1‐propanesulfonic acid) of arsenite developmental toxicity in mice . Ecotoxicol. Environ. Safety , 23 : 274 – 281 .
   PubMedGoogle Scholar
• Earnest , N. M. and Hood , R. D. 1981 . Effects of chronic prenatal exposure to sodium arsenite on mouse development and behavior . Teratology , 24 : S3A
   Google Scholar
• Ferm , V. H. 1972 . “ The teratogenic effects of metals on mammalian embryos ” . In Advances in teratology , Edited by: Woollam , D. H. M. vol. V , 51 – 75 . London : Logos Press .
   Google Scholar
• Ferm , V. H. 1977 . Arsenic as a teratogenic agent . Environ. Health Perspect. , 19 : 215 – 217 .
   PubMedGoogle Scholar
• Ferm , V. H. and Carpenter , S. 1968 . Malformations induced by sodium arsenate . J. Reprod. Fertil. , 17 : 199 – 201 .
   PubMedGoogle Scholar
• Ferm , V. H. and Hanlon , D. P. 1985 . Constant rate exposure of pregnant hamsters to arsenate during early gestation . Environ. Res. , 37 : 425 – 432 .
   PubMedGoogle Scholar
• Ferm , V. H. and Hanlon , D. P. 1986 . Arsenate‐induced neural tube defects not influenced by constant rate administration of folic acid . Pediatr. Res. , 20 : 761 – 762 .
   PubMed Web of Science ®Google Scholar
• Ferm , V. H. and Kilham , L. 1977 . Synergistic teratogenic effects of arsenic and hyperthermia in hamsters . Environ. Res. , 14 : 483 – 486 .
   PubMedGoogle Scholar
• Ferm , V. H. and Saxon , A. 1971 . Amniotic fluid volume in experimentally induced renal agenesis and anencephaly . Experientia , 27 : 1066 – 1068 .
   PubMedGoogle Scholar
• Ferm , V. H. , Saxon , A. and Smith , B. M. 1971 . The teratogenic profile of sodium arsenate in the golden hamster . Arch. Environ. Health , 22 : 552 – 560 .
   Google Scholar
• Fischer , A. B. , Buchet , J. P. and Lauwerys , R. R. 1985 . Arsenic uptake, cytotoxicity and detoxification studied in mammalian cells in culture . Arch. Toxicol. , 57 : 168 – 172 .
   PubMedGoogle Scholar
• Fisher , D. L. 1982 . Cultured rat embryo accumulation of DNA, RNA, and protein following maternal administration of sodium arsenate . Environ. Res. , 28 : 1 – 9 .
   PubMedGoogle Scholar
• Foa , V. , Colombi , A. , Maroni , M. , Buratti , M. and Calzaferri , G. 1984 . The speciation of the chemical forms of arsenic in the biological monitoring of exposure to inorganic arsenic . Sci. Total Environ. , 34 : 241 – 259 .
   PubMed Web of Science ®Google Scholar
• Freeman , G. B. , Johnson , J. D. , Killinger , J. M. , Liao , S. C. , Davis , A. O. , Ruby , M. V. , Chaney , R. L. , Lovre , S. C. and Bergstrom , P. D. 1993 . Bioavailability of arsenic in soil impacted by smelter activities following oral administration in rabbits . Fundam. Appl. Toxicol. , 20 : 83 – 88 .
   PubMedGoogle Scholar
• Freeman , G. B. , Schoof , R. A. , Ruby , M. V. , Davis , A. C. , Dill , J. A. , Liao , S. C. , Lapin , C. A. and Bergstrom , P. D. 1995 . Bioavailability of arsenic in soil and house dust impacted by smelter activities following oral administration in cynomolgus monkeys . Fundam. Appl. Toxicol. , 28 : 215 – 222 .
   PubMedGoogle Scholar
• Gencik , A. , Szokolayova , J. and Cerey , K. 1977 . Dominant lethal test after peroral administration of arsenic . Bratisl. Lek. Listy , 67 : 179 – 187 .
   PubMedGoogle Scholar
• General Accounting Office . 1991 . Reproductive and Developmental Toxicants: Regulatory Actions Provide Uncertain Protection , GAO/PEMD‐92‐3 Washington, DC : GAO .
   Google Scholar
• Gerber , G. B. , Maes , J. and Eykens , B. 1982 . Transfer of antimony and arsenic to the developing organism . Arch. Toxicol. , 49 : 159 – 168 .
   PubMed Web of Science ®Google Scholar
• German , J. 1984 . Embryonic stress hypothesis of teratogenesis . Am. J. Med. , 76 : 293 – 301 .
   PubMedGoogle Scholar
• Golub , M. S. 1994 . Maternal toxicity and the identification of inorganic arsenic as a developmental toxicant . Reprod. Toxicol. , 8 : 283 – 295 .
   PubMed Web of Science ®Google Scholar
• Gonzalez , M. J. , Aguilar , M. V. and Martinez Para , M. C. 1995 . Gastrointestinal absorption of inorganic arsenic(V): The effect of concentration and interactions with phosphate and dichromate . Vet. Hum. Toxicol. , 37 : 131 – 136 .
   PubMedGoogle Scholar
• Grandjean , P. , Weihe , P. , Needham , L. L. , Burse , V. W. , Patterson , D. G. Jr , Sampson , E. J. , Forgensen , P. J. and Vahter , M. 1995 . Relation of a seafood diet to mercury, selenium, arsenic and polychlorinated biphenyl and other organochlorine concentrations in human milk . Environ. Res. , 71 : 29 – 33 .
   PubMed Web of Science ®Google Scholar
• Hanlon , D. P. and Ferm , V. H. 1977 . Placental permeability of arsenate ion during early embryogenesis in the hamster . Experientia , 33 : 1221 – 1222 .
   PubMedGoogle Scholar
• Hanlon , D. P. and Ferm , V. H. 1986a . Concentration and chemical status of arsenic in the blood of pregnant hamsters during critical embryogenesis. 1. Subchronic exposure to arsenate utilizing constant rate administration . Environ. Res. , 40 : 372 – 379 .
   PubMed Web of Science ®Google Scholar
• Hanlon , D. P. and Ferm , V. H. 1986b . Concentration and chemical status of arsenic in the blood of pregnant hamsters during critical embryogenesis. 2. Acute exposure . Environ. Res. , 40 : 380 – 390 .
   PubMed Web of Science ®Google Scholar
• Hanlon , D. P. and Ferm , V. H. 1986c . Teratogen concentration changes as the basis of the heat stress enhancement of arsenate teratogenesis in hamsters . Teratology , 34 : 189 – 193 .
   PubMedGoogle Scholar
• Hanlon , D. P. and Ferm , V. H. 1987 . The concentration and chemical status of arsenic in the early placentas of arsenate‐dosed hamsters . Environ. Res. , 42 : 546 – 552 .
   PubMedGoogle Scholar
• Hazardous Substance Data Bank . 1995 . Arsenic , Englewood, CO. : National Library of Medicine, Bethesda, MD. MICROMEDEX, Inc. . Edition expiration date April 1
   Google Scholar
• Hazelton Laboratories of America . 1990 . Two Generation Dietary Reproduction Study with Arsenic Acid in Mice , Report HLA 6120‐138 Madison, WI : Hazelton Laboratories, Inc. .
   Google Scholar
• Healy , S. M. , Zakharyan , R. A. and Aposhian , H. V. 1996 . Does the guinea pig methylate arsenite and MMA? . Fundam. Appl. Toxicol. , 30 (1) : 89 – 90 . (suppl. Part 2)
   Google Scholar
• Holland , R. H. , McCall , M. S. and Lanz , H. C. 1959 . A study of inhaled 74As in man . Cancer Res. , 19 : 1154 – 1156 .
   Web of Science ®Google Scholar
• Holmberg , R. E. and Ferm , V. H. 1969 . Interrelationships of selenium, cadmium, and arsenic in mammalian teratogenesis . Arch. Environ. Health , 18 : 873 – 877 .
   PubMed Web of Science ®Google Scholar
• Honda , I.‐I. , Hatayama , R. , Takahashi , K.‐I. and Yukioka , M. 1992 . Heat shock proteins in human and mouse embryonic cells after exposure to heat shock or teratogenic agents . Teratogen. Carcinogen. Mutagen. , 11 : 235 – 244 .
   Google Scholar
• Hood , R. D. 1972 . Effects of sodium arsenite on fetal development . Bull. Environ. Contam. Toxicol. , 7 : 216 – 222 .
   PubMed Web of Science ®Google Scholar
• Hood , R. D. 1983 . “ Toxicology of prenatal exposure to arsenic ” . In Arsenic , Edited by: Lederer , W. H. and Fensterheim , R. J. 134 – 150 . New York : Van Nostrand Reinhold .
   Google Scholar
• Hood , R. D. 1989 . A perspective on the significance of maternally mediated developmental toxicity . Regul. Toxicol. Pharmacol. , 10 : 144 – 148 .
   PubMedGoogle Scholar
• Hood , R. D. and Vedel‐Macrander , G. C. 1984 . Evaluation of the effect of BAL (2,3 dimercaptopropanol) on arsenite‐induced teratogenesis in mice . Toxicol. Appl. Pharmacol. , 73 : 1 – 7 .
   PubMedGoogle Scholar
• Hood , R. D. and Bishop , S. L. 1972 . Teratogenic effects of sodium arsenate in mice . Arch. Environ. Health , 24 : 62 – 65 .
   PubMed Web of Science ®Google Scholar
• Hood , R. D. and Harrison , W. P. 1982 . Effects of prenatal arsenite exposure in the hamster . Bull. Environ. Contam. Toxicol. , 29 : 671 – 678 .
   PubMed Web of Science ®Google Scholar
• Hood , R. D. and Pike , C. T. 1972 . BAL alleviation of arsenate‐induced teratogenesis in mice . Teratology , 6 : 235 – 238 .
   PubMedGoogle Scholar
• Hood , R. D. , Thacker , G. T. and Patterson , B. L. 1977 . Effects in the mouse and rat of prenatal exposure to arsenic . Environ. Health Perspect. , 19 : 219 – 222 .
   PubMedGoogle Scholar
• Hood , R. D. , Thacker , G. T. , Patterson , B. L. and Szczech , G. M. 1978 . Prenatal effects of oral versus intraperitoneal sodium arsenate in mice . J. Environ. Pathol. Toxicol. , 1 : 857 – 864 .
   PubMedGoogle Scholar
• Hood , R. D. , Baxley , M. N. and Harrison , W. P. 1979 . Evaluation of chromated copper arsenate (CCA) for teratogenicity . Teratology , 19 : 31 A
   Google Scholar
• Hood , R. D. , Vedel‐Macrander , G.C. , Zaworotko , M. J. , Tatum , F. M. and Meeks , R. G. 1987 . Distribution, metabolism, and fetal uptake of pentavalent arsenic in pregnant mice following oral or intraperitoneal administration . Teratology , 35 : 19 – 25 .
   PubMedGoogle Scholar
• Hood , R. D. , Vedel , G. C. , Zaworotko , M. J. , Tatum , F. M. and Meeks , R. G. 1988 . Uptake, distribution, and metabolism of trivalent arsenic in the pregnant mouse . J. Toxicol. Environ. Health , 25 : 423 – 434 .
   PubMed Web of Science ®Google Scholar
• Hopenhayn‐Rich , C. , Smith , A. H. and Goeden , H. M. 1993 . Human studies do not support the methylation threshold hypothesis for the toxicity of inorganic arsenic . Environ. Res. , 60 : 161 – 177 .
   PubMed Web of Science ®Google Scholar
• Hughes , M. F. , Menache , M. and Thompson , D. J. 1994 . Dose‐dependent disposition of sodium arsenate in mice following acute oral exposure . Fundam. Appl. Toxicol. , 22 : 80 – 89 .
   PubMedGoogle Scholar
• International Agency for Research on Cancer . 1987 . Genetic and related effects: An updating of selected IARC monographs from Volumes 1 to 42 . IARC Monogr. Eval. Carcinogen. Risks Hum. , : 6
   Google Scholar
• Integrated Risk Information Service, US Environmental Protection Agency . 1 April 1995 . Arsenic, Inorganic , 1 April , Denver, CO : IRIS . TOMES Plus Databases.
   Google Scholar
• Kagey , B. T. , Bumgarner , J. E. and Creason , J. P. Arsenic levels in maternal‐fetal tissue sets . Trace substances in environmental health–XI. Proceedings of University of Missouri's 11th annual conference on trace substances in environmental health . Edited by: Hemphill , D. D. June . pp. 252 – 256 .
   Google Scholar
• Kamkin , A. B. 1982 . Reevaluation of maximum permissible concentrations of arsenic trioxide in the environmental air of inhabited areas . Gig. Sanit. , 4 : 6 – 9 .
   Google Scholar
• Kizer , K. W. , Warriner , T. E. and Book , S. A. 1988 . Sound science in the implementation of public policy: A case report on California's Proposition 65 . J. Am. Med. Assoc. , 260 : 951 – 955 .
   PubMed Web of Science ®Google Scholar
• Kojima , H. 1974 . Developmental pharmacology of arsenite. II. Effect of arsenite on pregnancy nutrition and hard tissue . Nippon Yakurigaku Zasshi , 70 : 149 – 163 .
   PubMedGoogle Scholar
• Kreppel , H. , Liu , J. , Liu , Y. , Reichl , F. X. and Klaassen , C. D. 1994 . Zinc‐induced arsenite tolerance in mice . Fundam. Appl. Toxicol. , 23 : 32 – 37 .
   PubMedGoogle Scholar
• Le , X. C. , Cullen , W. R. and Reimer , K. J. 1994 . Human urinary arsenic excretion after one‐time ingestion of seaweed, crab, and shrimp . Clin. Chem. , 40 : 617 – 624 .
   PubMed Web of Science ®Google Scholar
• Leonard , A. and Lauwerys , R. R. 1980 . Carcinogenicity, teratogenicity and mutagenicity of arsenic . Mutat. Res. , 75 : 49 – 62 .
   PubMed Web of Science ®Google Scholar
• Lianfang , W. and Jianzhong , H. 1994 . “ Chronic arsenism from drinking water in some areas of Xinjiang, China ” . In Advances in environmental science and technology. Arsenic in the Environment, Part II: Human health and ecosystem effects , Edited by: Nriagu , J. O. 159 – 172 . New York : John Wiley & Sons .
   Google Scholar
• Lindgren , A. , Danielsson , B. R. C. , Dencker , L. and Vahter , M. 1984 . Embryotoxicity of arsenite and arsenate: Distribution in pregnant mice and monkeys and effects of embryonic cells in vitro . Acta Pharmacol. Toxicol. , 54 : 311 – 320 .
   PubMedGoogle Scholar
• Lugo , C. , Cassady , C. and Palmisano , P. 1969 . Acute maternal arsenic intoxication with neonatal death . Am. J. Dis. Child. , 117 : 328 – 330 .
   PubMedGoogle Scholar
• Mann , S. , Droz , P. O. and Vahter , M. 1996 . A physiologically based pharmacokinetic model for arsenic exposure . Toxicol. Appl. Pharmacol. , 137 : 8 – 22 .
   PubMed Web of Science ®Google Scholar
• Marafante , E. and Vahter , M. 1987 . Solubility, retention, and metabolism of intratracheally and orally administered inorganic arsenic compounds in the hamster . Environ. Res. , 42 : 72 – 82 .
   PubMed Web of Science ®Google Scholar
• Mason , R. W. , Edwards , I. R. and Fisher , L. C. 1989 . Teratogenicity of combinations of sodium dichromate, sodium arsenate and copper sulphate in the rat . Comp. Biochem. Physiol. , 93C : 407 – 411 .
   Google Scholar
• Matsumoto , N. 1973 . Effects of Na‐arsenate on the growth and development of the foetal mice . Teratology , 8 : 98 (abstr.)
   Google Scholar
• Mirkes , P. E. and Cornel , L. 1992 . A comparison of sodium arsenite‐ and hyperthermia‐induced stress responses and abnormal development in cultured postimplantation rat embryos . Teratology , 46 : 251 – 259 .
   PubMedGoogle Scholar
• Morris , H. P. , Laug , E. P. , Morris , H. J. and Grant , R. L. 1938 . The growth and reproduction of rats fed diets containing lead acetate and arsenic trioxide and the lead and arsenic content of newborn and suckling rats . J. Pharmacol. Exp. Ther. , 64 : 420 – 445 .
   Google Scholar
• Morrissey , R. E. and Mottet , N. E. 1983 . Arsenic‐induced exencephaly in the mouse and associated lesions occurring during neurulation . Teratology , 28 : 399 – 411 .
   PubMedGoogle Scholar
• Muller , W. U. , Streffer , C. and Fischer‐Lahdo , C. 1986 . Toxicity of sodium arsenite in mouse embryos in vitro and its influence on radiation risk . Arch. Toxicol. , 59 : 172 – 175 .
   PubMedGoogle Scholar
• Nadeenko , V. G. , Lenchenko , V. G. , Genkina , S. B. and Arkhipenko , T. A. 1978 . Influence of tungsten, molybdenum, copper and arsenic in intrauterine development of the fetus . Farmakol. Toksikol. , 41 : 620 – 623 .
   PubMedGoogle Scholar
• Nagaraja , T. N. and Desiraju , T. 1993 . Regional alterations in the levels of brain biogenic amines, glutamate, GABA, and GAD activity due to chronic consumption of inorganic arsenic in developing and adult rats . Bull. Environ. Contam. Toxicol. , 50 : 100 – 107 .
   PubMed Web of Science ®Google Scholar
• Nagaraja , T. N. and Desiraju , T. 1994 . Effects on operant learning and brain acetylcholine esterase activity in rats following chronic inorganic arsenic intake . Hum. Exp. Toxicol. , 13 : 353 – 356 .
   PubMed Web of Science ®Google Scholar
• Nagymajtenyi , L. , Selypes , A. and Berencsi , G. 1985 . Chromosomal aberrations and fetotoxic effects of atmospheric arsenic exposure in mice . J. Appl. Toxicol. , 5 : 61 – 63 .
   PubMedGoogle Scholar
• Nordstrom , S. , Beckman , L. and Nordenson , I. 1978a . Occupational and environmental risks in and around a smelter in northern Sweden. I. Variations in birth weight . Hereditas , 88 : 43 – 46 .
   PubMed Web of Science ®Google Scholar
• Nordstrom , S. , Beckman , L. and Nordenson , I. 1978b . Occupational and environmental risks in and around a smelter in northern Sweden. III. Frequencies of spontaneous abortion . Hereditas , 88 : 51 – 54 .
   PubMed Web of Science ®Google Scholar
• Nordstrom , S. , Beckman , L. and Nordenson , I. 1979a . Occupational and environmental risks in and around a smelter in northern Sweden. V. Spontaneous abortion among female employees and decreased birth weight in their offspring . Hereditas , 90 : 291 – 296 .
   PubMed Web of Science ®Google Scholar
• Nordstrom , S. , Beckman , L. and Nordenson , I. 1979b . Occupational and environmental risks in and around a smelter in northern Sweden. VI. Congenital malformations . Hereditas , 90 : 297 – 302 .
   PubMed Web of Science ®Google Scholar
• Odanaka , Y. , Matano , O. and Goto , S. 1980 . Biomethylation of inorganic arsenic by the rat and some laboratory animals . Bull. Environ. Contam. Toxicol. , 24 : 452 – 459 .
   Web of Science ®Google Scholar
• Omura , M. , Tanaka , A. , Hirata , M. , Zhao , M. , Makita , Y. , Inque , N. , Cotoh , K. and Ishinishi , N . 1996 . Testicular toxicity of gallium arsenide, indium arsenide, and arsenic oxide in rats by repetitive intratracheal instillation . Fundam. Appl. Toxicol. , 32 : 72 – 78 .
   PubMedGoogle Scholar
• Osswald , H. and Goerttler , K. 1971 . Arsenic‐induced leucoses in mice after diaplacental and postnatal application . Verh. Dtsch. Ces. Pathol. , 26 : 289 – 293 .
   Google Scholar
• Poma , K. , Degraeve , M. , Kirsch‐Volders , M. and Susanne , C. 1981 . Cytogenetic analysis of bone marrow cells and spermatogonia of male mice after in vivo treatment with arsenic . Experientia , 37 : 129 – 130 .
   PubMedGoogle Scholar
• Pomroy , C. , Charbonneau , S. M. , McCollough , R. S. and Tam , G. K. H. 1980 . Human retention studies with 74 As . Toxicol. Appl. Pharmacol. , 53 : 550 – 556 .
   PubMed Web of Science ®Google Scholar
• Rasco , J. F. and Hood , R. D. 1994 . Effects of maternal restraint stress and sodium arsenate in mice . Reprod. Toxicol. , 8 : 49 – 54 .
   PubMed Web of Science ®Google Scholar
• Schroeder , H. A. and Mitchener , M. 1971 . Toxic effects of trace elements on the reproduction of mice and rats . Arch. Environ. Health , 23 : 102 – 106 .
   PubMed Web of Science ®Google Scholar
• Shalat , S. L. , Walker , D. B. and Finnel , R. X. 1996 . Role of arsenic as a reproductive toxin with particular attention to neural tube defects . J. Toxicol. Environ. Health , 48 : 253 – 272 .
   PubMed Web of Science ®Google Scholar
• Silaev , A. A. and Lemeshevskata , E. P. 1980 . Experimental data on the gonadotropic effect of cesium arsenate . Cig. Tr. Prof. Zabol. , 9 : 46 – 48 .
   Google Scholar
• Smith , A. H. , Goeden , H. , Shearn , V. , Bates , M. and Allen , H. 1990 . Health Risk Assessment for Arsenic Ingestion , Sacramento, CA : Office of Drinking Water, California State Department of Health Services .
   Google Scholar
• Sram , R. J. 1976 . Relationship between acute and chronic exposures in mutagenicity studies in mice . Mutat. Res. , 41 : 25 – 42 .
   PubMedGoogle Scholar
• Sram , R. J. and Bencko , V. 1974 . A contribution for the evaluation of the genetic risk of exposure to arsenic . Cesk. Hyg. , 19 : 308 – 315 .
   Google Scholar
• Styblo , M. , Yamauchi , H. and Thomas , D. J. 1995 . Comparative in vitro methylation of trivalent and pentavalent arsenicals . Toxicol. Appl. Pharmacol. , 135 : 172 – 178 .
   PubMed Web of Science ®Google Scholar
• Tabacova , S. 1986 . Maternal exposure to environmental chemicals . NeuroToxicology , 7 : 421 – 440 .
   PubMedGoogle Scholar
• Tabacova , S. , Baird , D. D. , Balabaeva , I. , Lolova , D. and Petrov , I. 1994 . Placental arsenic and cadmium in relation to lipid peroxides and glutathione levels in maternal‐infant pairs from a copper smelter area . Placenta , 15 : 873 – 881 .
   PubMed Web of Science ®Google Scholar
• Tabacova , S. , Hunter , E. S. III and Gladen , B. C. 1996 . Developmental toxicity of inorganic arsenic in whole embryo culture: Oxidation state, dose, time and gestational age dependence . Toxicol. Appl. Pharmacol. , 138 : 298 – 307 .
   PubMedGoogle Scholar
• Taubeneck , M. W. , Daston , G. P. , Rogers , J. M. and Keen , C. L. 1994 . Altered maternal zinc metabolism following exposure to diverse developmental toxicants . Reprod. Toxicol. , 8 : 25 – 40 .
   PubMed Web of Science ®Google Scholar
• Thieme , R. , Schramel , P. and Kurz , E. 1977 . Die spurenelementkonzentration der menschlichen plazenta in stark kontaminiertter umwelt . Gerburtshilfe und Frauen‐heilkunde , 37 : 756 – 761 .
   PubMed Web of Science ®Google Scholar
• U.S. Environmental Protection Agency . 1990 . Guidelines for developmental toxicity risk assessment . Fed Reg. , 65 (234) : 63798 – 63826 .
   Google Scholar
• U.S. Public Health Service, Agency for Toxic Substances and Disease Registry . October 1991 . Toxicological Profile for Arsenic October , Draft for Public Comment,
   Google Scholar
• U.S. Public Health Service, Agency for Toxic Substances and Disease Registry . 1992 . Toxicological Profile for Arsenic TP‐92/02
   Google Scholar
• Uthus , E. O. 1992 . Evidence for arsenic essentiality . Environ. Ceochem. Health , 14 : 55 – 58 .
   PubMed Web of Science ®Google Scholar
• Uthus , E. O. 1994 . “ Estimation of safe and adequate daily intake for arsenic ” . In Risk assessment of essential elements , Edited by: Mertz , W. , Abernathy , C. O. and Olin , S. S. 273 – 282 . Washington, DC : I LSI Press .
   Google Scholar
• Vahter , M. 1983 . “ Metabolism of arsenic ” . In Biological and environmental effects of arsenic , Edited by: Fowler , B. A. vol. 6 , 171 – 198 . Amsterdam : Elsevier .
   Google Scholar
• Vahter , M. 1994 . Species differences in the metabolism of arsenic compounds . Appl. Organometal. Chem. , 8 : 175 – 182 .
   Web of Science ®Google Scholar
• Vahter , M. , Couch , R. , Nermell , B. and Nilsson , R. 1995 . Lack of methylation of inorganic arsenic in the chimpanzee . Toxicol. Appl. Pharmacol. , 133 : 262 – 268 .
   PubMed Web of Science ®Google Scholar
• Valentine , J. L. , Kang , H. K. and Spivey , G. 1979 . Arsenic levels in human blood, urine, and hair in response to exposure via drinking water . Environ. Res. , 20 : 24 – 32 .
   PubMed Web of Science ®Google Scholar
• Wester , R. C. , Maibach , H. I. , Sedik , L. , Melendres , J. and Wade , M. 1993 . In vivo and in vitro percutaneous absorption and skin decontamination of arsenic from water and soil . Fundam. Appl. Toxicol. , 20 : 336 – 340 .
   PubMedGoogle Scholar
• WIL Research Laboratories . 1988a . A Teratology Study in Mice with Arsenic Acid (75%) , Ashland, OH : WIL Research Laboratories .
   Google Scholar
• WIL Research Laboratories . 1988b . A Teratology Study in Rabbits with Arsenic Acid (75%) , Ashland, OH : WIL Research Laboratories .
   Google Scholar
• Willhite , C. C. 1981 . Arsenic‐induced axial skeletal (dysraphic) disorders . Exp. Mol. Pathol. , 34 : 145 – 158 .
   PubMedGoogle Scholar
• Willhite , C. C. and Ferm , V. H. 1984 . “ Prenatal and developmental toxicology of arsenicals ” . In Nutritional and toxicological aspects of food safety , Edited by: Friedman , M. 205 – 228 . New York : Plenum Press .
   Google Scholar
• Zierler , S. , Theodore , M. , Cohen , A. and Rothman , K. J. 1988 . Chemical quality of maternal drinking water and congenital heart disease . Int. J. Epidemiol. , 17 : 589 – 594 .
   PubMed Web of Science ®Google Scholar