Exploring the multifaceted neuroprotective actions of gallic acid: a review

References

• Badhani, B.; Sharma, N.; Kakkar, R. Gallic Acid: A Versatile Antioxidant with Promising Therapeutic and Industrial Applications. RSC. Adv. 2015, 5(35), 27540–27557. DOI: 10.1039/C5RA01911G.
   Web of Science ®Google Scholar
• Amerine, M. A.; Ough, C. S. Methods for analysis of musts and wines; 1980.
   Google Scholar
• KHAN, A. L. I.; NAZAN, M. S.; Mat Jais Am, S. Flavonoids and Anti-oxidant Activity Mediated Gastroprotective Action of Leathery Murdah, Terminalia Coriacea (Roxb.) Wight & Arn. Leaf Methanolic Extract in Rats. Arq. Gastroenterol. 2017, 54(3), 183–191. DOI: 10.1590/s0004-2803.201700000-21.
   PubMedGoogle Scholar
• Bakrania, A. K.; Patel, S. S. Combination Treatment for Allergic conjunctivitis–Plant Derived Histidine Decarboxylase Inhibitor and H1 Antihistaminic Drug. Exp. Eye Res. 2015, 137, 32–38. DOI: 10.1016/j.exer.2015.05.020.
   PubMed Web of Science ®Google Scholar
• Locatelli, C.; Filippin-Monteiro, F. B.; Creczynski-Pasa, T. B. Alkyl Esters of Gallic Acid as Anticancer Agents: A Review. Eur. J. Med. Chem. 2013, 60, 233–239. DOI: 10.1016/j.ejmech.2012.10.056.
   PubMed Web of Science ®Google Scholar
• Veluri, R.; Singh, R. P.; Liu, Z.; Thompson, J. A.; Agarwal, R.; Agarwal, C. Fractionation of Grape Seed Extract and Identification of Gallic Acid as One of the Major Active Constituents Causing Growth Inhibition and Apoptotic Death of DU145 Human Prostate Carcinoma Cells. Carcinogenesis. 2006, 27(7), 1445–1453. DOI: 10.1093/carcin/bgi347.
   PubMed Web of Science ®Google Scholar
• Chia, Y. C.; Rajbanshi, R.; Calhoun, C.; Chiu, R. H. Anti-neoplastic Effects of Gallic Acid, a Major Component of Toona Sinensis Leaf Extract, on Oral Squamous Carcinoma Cells. Molecules. 2010, 15(11), 8377–8389. DOI: 10.3390/molecules15118377.
   PubMed Web of Science ®Google Scholar
• Inoue, M.; Suzuki, R.; LI, Z.; Takeda, T.; Ogihara, Y et al. Selective Induction of Cell Death in Cancer Cells by Gallic Acid. Biol. Pharm. Bull. 1995, 18(11), 1526–1530.
   PubMed Web of Science ®Google Scholar
• Ohno, Y.; Fukuda, K.; Takemura, G.; Toyota, M.; Watanabe, M.; Yasuda, N.; Xinbin, Q.; Maruyama, R.; Akao, S.; Gotou, K.;; et al. Induction of Apoptosis by Gallic Acid in Lung Cancer Cells. Anti-cancer Drugs. 1999, 10(9), 845–851.
   PubMed Web of Science ®Google Scholar
• Priscilla, D. H.; Prince, P. S. M. Cardioprotective Effect of Gallic Acid on Cardiac troponin-T, Cardiac Marker Enzymes, Lipid Peroxidation Products and Antioxidants in Experimentally Induced Myocardial Infarction in Wistar Rats. Chem. Biol .Interact. 2009, 179(2–3), 118–124.
   PubMed Web of Science ®Google Scholar
• Patel, S. S.; Goyal, R. K. Cardioprotective Effects of Gallic Acid in Diabetes-induced Myocardial Dysfunction in Rats. Pharmacognosy. Res. 2011, 3(4), 239. DOI: 10.4103/0974-8490.89743.
   PubMedGoogle Scholar
• Rasool, M. K.; Sabina, E. P.; Ramya, S. R.; Preety, P. et al. Hepatoprotective and antioxidant effects of gallic acid in paracetamol‐induced liver damage in mice. J. Pharm. Pharmacol. 2010, 62(5), 638–643.
   PubMed Web of Science ®Google Scholar
• Ohno, T.; Inoue, M.; Ogihara, Y. Cytotoxic Activity of Gallic Acid against Liver Metastasis of Mastocytoma Cells P-815. Anticancer. Res. 2001, 21(6A), 3875–3880.
   PubMed Web of Science ®Google Scholar
• Kim, M. J.; Seong, A. R.; Yoo, J. Y. et al. Gallic Acid, a Histone Acetyltransferase Inhibitor, Suppresses β‐amyloid Neurotoxicity by Inhibiting Microglial‐mediated Neuroinflammation. Mol. Nutr Food Res. 2011, 55(12), 1798–1808.
   PubMed Web of Science ®Google Scholar
• Kroes, B. V.; Van den Berg, A.; Van Ufford, H. Q.; Van Dijk, H.; Labadie, R. Anti-inflammatory Activity of Gallic Acid. Planta. Med. 1992, 58(6), 499–504. DOI: 10.1055/s-2006-961535.
   PubMed Web of Science ®Google Scholar
• Sun J, Li Y-z, Ding Y-h. et al. Neuroprotective Effects of Gallic Acid against Hypoxia/reoxygenation-induced Mitochondrial Dysfunctions in Vitro and Cerebral Ischemia/reperfusion Injury in Vivo. Brain. Res. 2014, 1589, 126–139. DOI: 10.1016/j.brainres.2014.09.039.
   PubMed Web of Science ®Google Scholar
• Mansouri, M. T.; Farbood, Y.; Sameri, M. J.; Sarkaki, A.; Naghizadeh, B.; Rafeirad, M. Neuroprotective Effects of Oral Gallic Acid against Oxidative Stress Induced by 6-hydroxydopamine in Rats. Food. Chem. 2013, 138(2–3), 1028–1033. DOI: 10.1016/j.foodchem.2012.11.022.
   PubMed Web of Science ®Google Scholar
• Yu, M.; Chen, X.; Liu, J, et al. Gallic acid disruption of Aβ1–42 aggregation rescues cognitive decline of APP/PS1 double transgenic mouse. Neurobiol. Dis. 2019, 124, 67–80. DOI: 10.1016/j.nbd.2018.11.009.
   PubMed Web of Science ®Google Scholar
• Alzheimer’s, A.;. Alzheimer’s Disease Facts and Figures. Alzheimer’s Dementia. J. Alzheimers Dis. 2015, 11(3), 332.
   PubMed Web of Science ®Google Scholar
• Scapagnini, G.; Caruso, C.; Calabrese, V. Therapeutic potential of dietary polyphenols against brain ageing and neurodegenerative disorders.  Bio-Farms for Nutraceuticals. 2010, 12(2), 27–35.
   Google Scholar
• Rabiei, Z.; Rafieian-Kopaei, M.; Heidarian, E.; Saghaei, E.; Mokhtari, S. Effects of Zizyphus Jujube Extract on Memory and Learning Impairment Induced by Bilateral Electric Lesions of the Nucleus Basalis of Meynert in Rat. Neurochem. Res. 2014, 39(2), 353–360. DOI: 10.1007/s11064-013-1232-8.
   PubMed Web of Science ®Google Scholar
• Rabiei, Z.; Setorki, M. Effect of Hydroalcoholic Echium Amoenum Extract on Scopolamine-induced Learning and Memory Impairment in Rats. Pharm. Biol. 2018, 56(1), 672–677. DOI: 10.1080/13880209.2018.1543330.
   PubMed Web of Science ®Google Scholar
• Rabiei, Z.; Rafieian-Kopaei, M. Neuroprotective Effect of Pretreatment with Lavandula Officinalis Ethanolic Extract on Blood-brain Barrier Permeability in a Rat Stroke Model. Asian Pac. J. Trop. Med. 2014, 7, S421–S6. DOI: 10.1016/S1995-7645(14)60269-8.
   PubMed Web of Science ®Google Scholar
• Rabiei, Z.; Bigdeli, M. R.; Rasoulian, B.; Ghassempour, A.; Mirzajani, F. The Neuroprotection Effect of Pretreatment with Olive Leaf Extract on Brain Lipidomics in Rat Stroke Model. Phytomedicine. 2012, 19(10), 940–946. DOI: 10.1016/j.phymed.2012.06.003.
   PubMed Web of Science ®Google Scholar
• Rabiei, Z.; Gholami, M.; Rafieian-Kopaei, M. Antidepressant Effects of Mentha Pulegium in Mice. Bangladesh J. Pharmacol. 2016, 11(3), 711–715. DOI: 10.3329/bjp.v11i3.27318.
   Web of Science ®Google Scholar
• Rabiei, Z.; Mokhtrari, S.; Babaei, F.; Rafieian, K. M. Effect of Kombucha Tea on Depression and Motor Activity in Mice. J MEDICIN PLANTS.  2017, 16(10), 156–166.
   Google Scholar
• Rabiei, Z.; Naderi, S.; Rafieian-Kopaei, M. Study of Antidepressant Effects of Grape Seed Oil in Male Mice Using Tail Suspension and Forced Swim Tests. Bangladesh J. Pharmacol. 2017 Nov 5, 12(4), 397–402. DOI: 10.3329/bjp.v12i4.33520.
   Web of Science ®Google Scholar
• Rabiei, Z.; Jahanbazi, S.; Alibabaei, Z.; Rafieian-Kopaei, M. Antidepressant Effects of Oleuropein in Male Mice by Forced Swim Test and Tail Suspension Test. Middle. East J. 2018, 7(10), 132.
   Google Scholar
• Salehi, A.; Rabiei, Z.; Setorki, M. Effect of Gallic Acid on Chronic Restraint Stress-induced Anxiety and Memory Loss in Male BALB/c Mice. Iran. J. Basic Med. Sci. 2018, 21(12), 1232.
   PubMed Web of Science ®Google Scholar
• Kelsey, N. A.; Wilkins, H. M.; Linseman, D. A. Nutraceutical Antioxidants as Novel Neuroprotective Agents. Molecules. 2010, 15(11), 7792–7814. DOI: 10.3390/molecules15117792.
   PubMed Web of Science ®Google Scholar
• Grammas, P.;. Neurovascular Dysfunction, Inflammation and Endothelial Activation: Implications for the Pathogenesis of Alzheimer’s Disease. J. Neuroinflammation. 2011, 8(1), 26. DOI: 10.1186/1742-2094-8-26.
   PubMedGoogle Scholar
• Kade, I.; Rocha, J. Gallic Acid Modulates Cerebral Oxidative Stress Conditions and Activities of Enzyme-dependent Signaling Systems in Streptozotocin-treated Rats. Neurochem. Res. 2013, 38(4), 761–771. DOI: 10.1007/s11064-013-0975-6.
   PubMed Web of Science ®Google Scholar
• Thanyacharoen, T.; Chuysinuan, P.; Techasakul, S.; Nooeaid, P.; Ummartyotin, S. Development of a Gallic Acid-loaded Chitosan and Polyvinyl Alcohol Hydrogel Composite: Release Characteristics and Antioxidant Activity. Int. J. Biol. Macromol. 2018, 107, 363–370. DOI: 10.1016/j.ijbiomac.2017.09.002.
   PubMed Web of Science ®Google Scholar
• Rashid, K. A.; Baldwin, I. I.; Babish, J. G.; Schultz, J. C.; Mumma, R. O. Mutagenicity Tests with Gallic and Tannic Acid in the Salmonella/mammalian Microsome Assay. J. Environ. Sci. Heal. B. 1985, 20(2), 153–165. DOI: 10.1080/03601238509372473.
   PubMed Web of Science ®Google Scholar
• Dollahite, J.; Pigeon, R.; Camp, B. The Toxicity of Gallic Acid, Pyrogallol, Tannic Acid, and Quercus Havardi in the Rabbit. Am. J. Vet. Res. 1962, 23, 1264–1267.
   PubMed Web of Science ®Google Scholar
• Variya, B. C.; Bakrania, A. K.; Madan, P.; Patel, S. S. Acute and 28-days Repeated Dose Sub-acute Toxicity Study of Gallic Acid in Albino Mice. Regul. Toxicol Pharmacol. 2019, 101, 71–78. DOI: 10.1016/j.yrtph.2018.11.010.
   PubMed Web of Science ®Google Scholar
• Niho, N.; Shibutani, M. et al. Subchronic Toxicity Study of Gallic Acid by Oral Administration in F344 Rats. Food. Chem. Toxicol. 2001, 39(11), 1063–1070.
   PubMed Web of Science ®Google Scholar
• .Locatelli, C.; Rosso, R. et al. Ester Derivatives of Gallic Acid with Potential Toxicity toward L1210 Leukemia Cells. Bioorg. Med. Chem. 2008, 16(7), 3791–3799.
   PubMed Web of Science ®Google Scholar
• Bishayee, A.; Darvesh, A. Oxidative Stress in Cancer and Neurodegenerative Diseases: Prevention and Treatment by Dietary Antioxidants. Free RadicalsFormation, Types and Effects. 2010, 34, 1–55.
   Google Scholar
• Yen, G.-C.; Duh, P.-D.; Tsai, H.-L. Antioxidant and Pro-oxidant Properties of Ascorbic Acid and Gallic Acid. Food Chem. 2002, 79(3), 307–313. DOI: 10.1016/S0308-8146(02)00145-0.
   Web of Science ®Google Scholar
• Aruoma, O. I.; Murcia, A.; Butler, J.; Halliwell, B. Evaluation of the Antioxidant and Prooxidant Actions of Gallic Acid and Its Derivatives. J. Agric. Food Chem. 1993, 41(11), 1880–1885. DOI: 10.1021/jf00035a014.
   Web of Science ®Google Scholar
• Manoharan, S.; Guillemin, G. J.; Abiramasundari, R. S.; Essa, M. M.; Akbar, M.; Akbar, M. D. The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review. Oxid. Med. Cell Longev. 2016, 2016, 1–15. DOI: 10.1155/2016/8590578.
   Web of Science ®Google Scholar
• Liu, Y.-L.; Hsu, -C.-C.; Huang, H.-J.; Chang, C.-J.; Sun, S.-H.; M-Y, L. A. Gallic Acid Attenuated LPS-Induced Neuroinflammation: Protein Aggregation and Necroptosis. Mol. Neurobiol. 2020, 57(1), 96–104. DOI: 10.1007/s12035-019-01759-7.
   PubMed Web of Science ®Google Scholar
• Siddiqui, S.; Kamal, A.; Khan, F.; Jamali, K. S.; Saify, Z. S. Gallic and Vanillic Acid Suppress Inflammation and Promote Myelination in an in Vitro Mouse Model of Neurodegeneration. Mol. Biol. Rep. 2019, 46(1), 997–1011. DOI: 10.1007/s11033-018-4557-1.
   PubMed Web of Science ®Google Scholar
• Selkoe, D. J.; Hardy, J. The Amyloid Hypothesis of Alzheimer’s Disease at 25 Years. EMBO Molecular Med. 2016, 8(6), 595–608. DOI: 10.15252/emmm.201606210.
   PubMed Web of Science ®Google Scholar
• .Ghochikyan, A.; Petrushina, I.; Lees, A et al. A β-Immunotherapy for Alzheimer’s Disease Using Mannan–Amyloid-Beta Peptide Immunoconjugates. DNA Cell Biol. 2006, 25(10), 571–580.
   PubMed Web of Science ®Google Scholar
• Van Marum, R. J.;. Current and Future Therapy in Alzheimer’s Disease. Fund. Clin. Pharmacol. 2008, 22(3), 265–274. DOI: 10.1111/j.1472-8206.2008.00578.x.
   PubMed Web of Science ®Google Scholar
• Tõugu, V.; Tiiman, A.; Palumaa, P. Interactions of Zn (II) and Cu (II) Ions with Alzheimer’s Amyloid-beta Peptide. Metal Ion Binding, Contribution to Fibrillization and Toxicity. Metallomics. 2011, 3(3), 250–261. DOI: 10.1039/c0mt00073f.
   PubMed Web of Science ®Google Scholar
• Savelieff, M. G.; DeToma, A. S.; Derrick, J. S.; Lim, M. H. The Ongoing Search for Small Molecules to Study Metal-associated amyloid-β Species in Alzheimer’s Disease. Acc. Chem. Res. 2014, 47(8), 2475–2482. DOI: 10.1021/ar500152x.
   PubMed Web of Science ®Google Scholar
• Khan, A. N.; Hassan, M. N.; Khan, R. H. Gallic Acid: A Naturally Occurring Bifunctional Inhibitor of Amyloid and Metal Induced Aggregation with Possible Implication in Metal-based Therapy. J. Mol. Liq. 2019, 285, 27–37. DOI: 10.1016/j.molliq.2019.04.059.
   Web of Science ®Google Scholar
• Bloom, G. S.;. Amyloid-β and Tau: The Trigger and Bullet in Alzheimer Disease Pathogenesis. JAMA neurol. 2014, 71(4), 505–508. DOI: 10.1001/jamaneurol.2013.5847.
   PubMed Web of Science ®Google Scholar
• Ferreira-Vieira, H.; Guimaraes, T. M.; Silva, I. R.; Ribeiro, F. M. Alzheimer’s Disease: Targeting the Cholinergic System. Curr. Neuropharmacol. 2016, 14(1), 101–115. DOI: 10.2174/1570159X13666150716165726.
   PubMed Web of Science ®Google Scholar
• Lipton, S. A.;. The Molecular Basis of Memantine Action in Alzheimer’s Disease and Other Neurologic Disorders: Low-affinity, Uncompetitive Antagonism. Curr. Alzheimer Res. 2005, 2(2), 155–165. DOI: 10.2174/1567205053585846.
   PubMedGoogle Scholar
• Salomone, S.; Caraci, F.; Leggio, G. M.; Fedotova, J.; Drago, F. New Pharmacological Strategies for Treatment of Alzheimer’s Disease: Focus on Disease Modifying Drugs. Br. J. Clin. Pharmacol. 2012, 73(4), 504–517. DOI: 10.1111/j.1365-2125.2011.04134.x.
   PubMed Web of Science ®Google Scholar
• Bartolini, M.; Marco‐Contelles, J. Tacrines as Therapeutic Agents for Alzheimer’s Disease. IV. The Tacripyrines and Related Annulated Tacrines. Chem. Rec. 2019, 19(5), 927–937. DOI: 10.1002/tcr.201800155.
   PubMed Web of Science ®Google Scholar
• Ghezzi, L.; Scarpini, E.; Galimberti, D. Disease-modifying Drugs in Alzheimer’s Disease. Drug Des. Dev. Ther. 2013, 7, 1471.
   PubMed Web of Science ®Google Scholar
• Robinson, S. R.; Bishop, G. M.; Lee, H.-G.; Münch, G. Lessons from the AN 1792 Alzheimer Vaccine: Lest We Forget. Neurobiol. Aging. 2004, 25(5), 609–615. DOI: 10.1016/j.neurobiolaging.2003.12.020.
   PubMed Web of Science ®Google Scholar
• Prins, N. D.; Scheltens, P. Treating Alzheimer’s Disease with Monoclonal Antibodies: Current Status and Outlook for the Future. Alzheimer’s Res. Ther. 2013, 5(6), 56. DOI: 10.1186/alzrt220.
   PubMed Web of Science ®Google Scholar
• Salloway,  S.; Sperling,  R.; Fox,  N. C. et al. Two Phase 3 Trials of Bapineuzumab in Mild-to-moderate Alzheimer’s Disease. N. Engl. J. Med. 2014, 370(4), 322–333.
   PubMed Web of Science ®Google Scholar
• Wischik, C. M.; Harrington, C. R.; Storey, J. M. Tau-aggregation Inhibitor Therapy for Alzheimer’s Disease. Biochem Pharmacol. 2014, 88(4), 529–539. DOI: 10.1016/j.bcp.2013.12.008.
   PubMed Web of Science ®Google Scholar
• Hajipour, S.; Sarkaki, A.; Farbood, Y.; Eidi, A.; Mortazavi, P.; Valizadeh, Z. Effect of Gallic Acid on Dementia Type of Alzheimer Disease in Rats: Electrophysiological and Histological Studies. Basic. Clini Neuro. 2016, 7(2), 97.
   PubMed Web of Science ®Google Scholar
• Ferruzzi, M. G.; Lobo, J. K.; Janle, E. M.; Cooper, B.; Simon, J. E.; Wu, Q.-L.; Welch, C.; Ho, L.; Weaver, C.; Pasinetti, G. M.;; et al. Bioavailability of Gallic Acid and Catechins from Grape Seed Polyphenol Extract Is Improved by Repeated Dosing in Rats: Implications for Treatment in Alzheimer’s Disease. J. Alzheimers Dis. 2009, 18(1), 113–124.
   PubMed Web of Science ®Google Scholar
• Liu, Y.; Pukala, T. L.; Musgrave, I. F.; Williams, D. M.; Dehle, F. C.; Carver, J. A. Gallic Acid Is the Major Component of Grape Seed Extract that Inhibits Amyloid Fibril Formation. Bioorg. Med. Chem. Lett. 2013, 23(23), 6336–6340. DOI: 10.1016/j.bmcl.2013.09.071.
   PubMed Web of Science ®Google Scholar
• Mansouri, M. T.; Naghizadeh, B.; Ghorbanzadeh, B.; Farbood, Y.; Sarkaki, A.; Bavarsad, K. Gallic Acid Prevents Memory Deficits and Oxidative Stress Induced by Intracerebroventricular Injection of Streptozotocin in Rats. Pharmacol .Biochem Behav. 2013, 111, 90–96. DOI: 10.1016/j.pbb.2013.09.002.
   PubMed Web of Science ®Google Scholar
• Baziyar, Y.; Edalatmanesh, M. A.; Hosseini, S. A.; Zar, A. The Effects of Endurance Training and Gallic Acid on BDNF and TNF-a in Male Rats with Alzheimer. Int. J. Appl. Exerc. Physiol. 2016, 5(4), 45–54.
   Web of Science ®Google Scholar
• Nagpal, K.; Singh, S.; Mishra, D. Optimization of Brain Targeted Gallic Acid Nanoparticles for Improved Antianxiety-like Activity. Int. J. Biol. Macromol. 2013, 57, 83–91. DOI: 10.1016/j.ijbiomac.2013.03.022.
   PubMed Web of Science ®Google Scholar
• Ogunsuyi, O. B.; Oboh, G.; Oluokun, O. O, et al. Gallic Acid Protects against Neurochemical Alterations in Transgenic Drosophila Model of Alzheimer’s Disease. Orient. Pharm Exp Med. 2019, 1–10.
   Google Scholar
• Lang, A.; Lozano, A. M. Parkinson’s Disease. First of Two Parts. N. Engl. J. Med. 1998, 339(15), 1044–1053. DOI: 10.1056/NEJM199810083391506.
   PubMed Web of Science ®Google Scholar
• De Lau, L. M.; Breteler, M. M. Epidemiology of Parkinson’s Disease. Lancet. Neurol. 2006, 5(6), 525–535. DOI: 10.1016/S1474-4422(06)70471-9.
   PubMed Web of Science ®Google Scholar
• Reckziegel, P.; Peroza, L. R.; Schaffer,  L. F. et al. Gallic Acid Decreases Vacuous Chewing Movements Induced by Reserpine in Rats. Pharmacol. Biochem. Behav. 2013, 104, 132–137. DOI: 10.1016/j.pbb.2013.01.001.
   PubMed Web of Science ®Google Scholar
• Kasture, V. S.; Katti, S. A.; Mahajan, D.; Wagh, R.; Mohan, M.; Kasture, S. B. Antioxidant and Antiparkinson Activity of Gallic Acid Derivatives. Pharmacologyonline. 2009, 1, 385–395.
   Google Scholar
• Chandrasekhar, Y.; Kumar, G. P.; Ramya, E.; Anilakumar, K. Gallic Acid Protects 6-OHDA Induced Neurotoxicity by Attenuating Oxidative Stress in Human Dopaminergic Cell Line. Neurochem. Res. 2018, 43(6), 1150–1160. DOI: 10.1007/s11064-018-2530-y.
   PubMed Web of Science ®Google Scholar
• Chen, H.; Yoshioka, H.; Kim, G. S. et al. Oxidative Stress in Ischemic Brain Damage: Mechanisms of Cell Death and Potential Molecular Targets for Neuroprotection. Antioxid. 2011, 14(8), 1505–1517.
   Web of Science ®Google Scholar
• Christophe, M.; Nicolas, S. Mitochondria: A Target for Neuroprotective Interventions in Cerebral Ischemia-reperfusion. Curr. Pharm. Des. 2006, 12(6), 739–757. DOI: 10.2174/138161206775474242.
   PubMed Web of Science ®Google Scholar
• .White, B. C.; Sullivan, J. M.; DeGracia, D. J. et al. Brain Ischemia and Reperfusion: Molecular Mechanisms of Neuronal Injury. J. Neurol. Sci. 2000, 179(1–2), 1–33.
   PubMed Web of Science ®Google Scholar
• Korani, M. S.; Farbood, Y.; Sarkaki, A.; Moghaddam, H. F.; Mansouri, M. T. Protective Effects of Gallic Acid against Chronic Cerebral Hypoperfusion-induced Cognitive Deficit and Brain Oxidative Damage in Rats. Eur. J Pharmacol. 2014, 733, 62–67. DOI: 10.1016/j.ejphar.2014.03.044.
   PubMed Web of Science ®Google Scholar
• Sarkaki, A.; Fathimoghaddam, H.; Mansouri, S. M. T.; Shahram Korram, M.; Saki, G.; Farbood, Y. Gallic Acid Improves Cognitive, Hippocampal Long-term Potentiation Deficits and Brain Damage Induced by Chronic Cerebral Hypoperfusion in Rats. PJBS. 2014, 17(8), 978–990. DOI: 10.3923/pjbs.2014.978.990.
   PubMedGoogle Scholar
• Farbood, Y.; Sarkaki, A.; Hashemi, S.; Mansouri, M. T.; Dianat, M. The Effects of Gallic Acid on Pain and Memory following Transient Global Ischemia/reperfusion in Wistar Rats. Avicenna. J Phytomed. 2013, 3(4), 329.
   PubMedGoogle Scholar
• Tsigos, C.; Chrousos, G. P. Hypothalamic–pituitary–adrenal Axis, Neuroendocrine Factors and Stress. J. Psychosom. Res. 2002, 53(4), 865–871. DOI: 10.1016/S0022-3999(02)00429-4.
   PubMed Web of Science ®Google Scholar
• Ago, Y.; Arikawa, S.; Yata, M. et al. Antidepressant-like Effects of the Glucocorticoid Receptor Antagonist RU-43044 are Associated with Changes in Prefrontal Dopamine in Mouse Models of Depression. Neuropharmacol. 2008, 55(8), 1355–1363.
   PubMed Web of Science ®Google Scholar
• Pan, Y.; Kong, L.; Xia, X.; Zhang, W.; Xia, Z.; Jiang, F. Antidepressant-like Effect of Icariin and Its Possible Mechanism in Mice. Pharmacol. Biochem. Behav. 2005, 82(4), 686–694. DOI: 10.1016/j.pbb.2005.11.010.
   PubMed Web of Science ®Google Scholar
• Spiers, J. G.; Chen H-J, C.; Sernia, C.; Lavidis, N. A. Activation of the Hypothalamic-pituitary-adrenal Stress Axis Induces Cellular Oxidative Stress. Front. Neurosci. 2015, 8, 456. DOI: 10.3389/fnins.2014.00456.
   PubMed Web of Science ®Google Scholar
• Lowy, M., . T.; Gault, L.; Yamamoto, B. K. Rapid Communication: Adrenalectomy Attenuates Stress‐induced Elevations in Extracellular Glutamate Concentrations in the Hippocampus. J. Neurochem. 1993, 61(5), 1957–1960. DOI: 10.1111/j.1471-4159.1993.tb09839.x.
   PubMed Web of Science ®Google Scholar
• Amani, M.; Samadi, H.; Doosti, M-H. et al. Neonatal NMDA Receptor Blockade Alters Anxiety-and Depression-related Behaviors in a Sex-dependent Manner in Mice. Neuropharmacol. 2013, 73, 87–97. DOI: 10.1016/j.neuropharm.2013.04.056.
   PubMed Web of Science ®Google Scholar
• Li, N.; Liu, R-J.; Dwyer, J. M. et al. Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure. Biol. Psychiatry. 2011, 69(8), 754–761.
   PubMed Web of Science ®Google Scholar
• Dabbagh, A. J.; Mannion, T.; Lynch, S.; Frei, B. The Effect of Iron Overload on Rat Plasma and Liver Oxidant Status in Vivo. Biochem. J. 1994, 300(3), 799–803. DOI: 10.1042/bj3000799.
   PubMedGoogle Scholar
• Kawabata, K.; Kawai, Y.; Terao, J. Suppressive Effect of Quercetin on Acute Stress-induced Hypothalamic-pituitary-adrenal Axis Response in Wistar Rats. J. Nutr Biochem. 2010, 21(5), 374–380. DOI: 10.1016/j.jnutbio.2009.01.008.
   PubMed Web of Science ®Google Scholar
• Pereira,  M. M.;  de Morais,  H.;  dos Santos Silva,  E. et al. The Antioxidant Gallic Acid Induces Anxiolytic-, but Not Antidepressant-like Effect, in Streptozotocin-induced Diabetes. Metab. Brain Dis. 2018, 33(5), 1573–1584.
   PubMed Web of Science ®Google Scholar
• Dhingra, D.; Chhillar, R.; Gupta, A. Antianxiety-like Activity of Gallic Acid in Unstressed and Stressed Mice: Possible Involvement of Nitriergic System. Neurochem. Res. 2012, 37(3), 487–494. DOI: 10.1007/s11064-011-0635-7.
   PubMed Web of Science ®Google Scholar
• Mansouri, M. T.; Soltani, M.; Naghizadeh, B.; Farbood, Y.; Mashak, A.; Sarkaki, A. A Possible Mechanism for the Anxiolytic-like Effect of Gallic Acid in the Rat Elevated Plus Maze. Pharmacol. Biochem. Behav. 2014, 117, 40–46. DOI: 10.1016/j.pbb.2013.12.011.
   PubMed Web of Science ®Google Scholar
• Can, Ö. D.; Turan, N.; Özkay, Ü. D.; Öztürk, Y. Antidepressant-like Effect of Gallic Acid in Mice: Dual Involvement of Serotonergic and Catecholaminergic Systems. Life. Sci. 2017, 190, 110–117. DOI: 10.1016/j.lfs.2017.09.023.
   PubMed Web of Science ®Google Scholar
• Chhillar, R.; Dhingra, D. Antidepressant‐like Activity of Gallic Acid in Mice Subjected to Unpredictable Chronic Mild Stress. Fundam. Clin. Pharmacol. 2013, 27(4), 409–418. DOI: 10.1111/j.1472-8206.2012.01040.x.
   PubMed Web of Science ®Google Scholar
• Nagpal, K.; Singh, S. K.; Mishra, D. N. Nanoparticle Mediated Brain Targeted Delivery of Gallic Acid: In Vivo Behavioral and Biochemical Studies for Improved Antioxidant and Antidepressant-like Activity. Drug. Deliv. 2012, 19(8), 378–391. DOI: 10.3109/10717544.2012.738437.
   PubMed Web of Science ®Google Scholar
• Nabavi, S.; Habtemariam, S.; Di Lorenzo, A.; Sureda, A.; Khanjani, S.; Daglia, M. Post-stroke Depression Modulation and in Vivo Antioxidant Activity of Gallic Acid and Its Synthetic Derivatives in a Murine Model System. Nutrients. 2016, 8(5), 48. DOI: 10.3390/nu8050248.
   Web of Science ®Google Scholar
• Samad, N.; Jabeen, S.; Imran, I.; Zulfiqar, I.; Bilal, K. Protective Effect of Gallic Acid against Arsenic-induced Anxiety−/depression-like Behaviors and Memory Impairment in Male Rats. Metab. Brain Dis. 2019, 34(4), 1091–1102. DOI: 10.1007/s11011-019-00432-1.
   PubMed Web of Science ®Google Scholar
• Huang, H-L.; Lin, C-C.; Jeng, K-CG. et al. Fresh Green Tea and Gallic Acid Ameliorate Oxidative Stress in Kainic Acid-induced Status Epilepticus. J. Agr. Food. Chem. 2012, 60(9), 2328–2336.
   PubMed Web of Science ®Google Scholar
• Sarkaki, A.; Farbood, Y.; Gharib-Naseri, M. K. et al. Gallic Acid Improved Behavior, Brain Electrophysiology, and Inflammation in a Rat Model of Traumatic Brain Injury. Can. J. Physiol. Pharm. 2015, 93(8), 687–694.
   PubMed Web of Science ®Google Scholar
• Mirshekar, M.A.; Sarkaki, A.;  Farbood,  Y. et al. Neuroprotective Effects of Gallic Acid in a Rat Model of Traumatic Brain Injury: Behavioral, Electrophysiological, and Molecular Studies. Iran J. Basic Med. Sci. 2018, 21(10), 1056.
   PubMed Web of Science ®Google Scholar
• Georgieva, A.; Belcheva, S.; Tashev, R.; Valcheva-Kuzmanova, S. Effects of Gallic Acid on Exploratory Behavior and Locomotor Activity in Rats. Trakia J. Sci. 2015, 13(2), 29–33. DOI: 10.15547/tjs.2015.s.02.007.
   Google Scholar
• Maya, S.; Prakash, T.; Goli, D. Evaluation of Neuroprotective Effects of Wedelolactone and Gallic Acid on Aluminium-induced Neurodegeneration: Relevance to Sporadic Amyotrophic Lateral Sclerosis. Eur J. Pharmacol. 2018, 835, 41–51. DOI: 10.1016/j.ejphar.2018.07.058.
   PubMed Web of Science ®Google Scholar
• Reckziegel, P.; Dias, V. T.; Benvegnú, D.; Boufleur, N.; Barcelos, R. C. S.; Segat, H. J.; Pase, C. S.; Dos Santos, C. M. M.; Flores, É. M. M.; Bürger, M. E.;; et al. Locomotor Damage and Brain Oxidative Stress Induced by Lead Exposure are Attenuated by Gallic Acid Treatment. Toxicol. Lett. 2011, 203(1), 74–81.
   PubMed Web of Science ®Google Scholar
• Backonja, -M.-M.;. Use of Anticonvulsants for Treatment of Neuropathic Pain. Neurology. 2002, 59(5suppl 2), S14–S7. DOI: 10.1212/WNL.59.5_suppl_2.S14.
   PubMedGoogle Scholar
• Chowdhury, M. R.; Moshikur, R. M.; Wakabayashi,  R. et al. Ionic-liquid-based Paclitaxel Preparation: A New Potential Formulation for Cancer Treatment. Mol. Pharm. 2018, 15(6), 2484–2488.
   PubMedGoogle Scholar
• Kaur, S.; Muthuraman, A. Ameliorative Effect of Gallic Acid in Paclitaxel-induced Neuropathic Pain in Mice. Toxicol. Rep. 2019, 6, 505–513. DOI: 10.1016/j.toxrep.2019.06.001.
   PubMed Web of Science ®Google Scholar
• Kim, J.; Lee, H. J.; Lee, K. W. Naturally Occurring Phytochemicals for the Prevention of Alzheimer’s Disease. J. Neurochem. 2010, 112(6), 1415–1430. DOI: 10.1111/j.1471-4159.2009.06562.x.
   PubMed Web of Science ®Google Scholar
• Pasinetti, G. M.; Wang, J.; Ho, L.; Zha, W.; Dubner, L. Roles of Resveratrol and Other Grape-derived Polyphenols in Alzheimer’s Disease Prevention and Treatment. Biochim. Biophys. Acta. 2015, 1852(6), 1202–1208. DOI: 10.1016/j.bbadis.2014.10.006.
   PubMed Web of Science ®Google Scholar
• Nagpal, K.; Singh, S.; Mishra, D. Nanoparticle Mediated Brain Targeted Delivery of Gallic Acid: In Vivo Behavioral and Biochemical Studies for Protection against Scopolamine-induced Amnesia. Drug. Deliv. 2013, 20(3–4), 112–119. DOI: 10.3109/10717544.2013.779330.
   PubMed Web of Science ®Google Scholar