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International Journal of Food Properties Volume 26, 2023 - Issue 1
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Review

Antioxidant, phytochemical, and therapeutic properties of medicinal plants: a review

Onyenibe Sarah Nwozoa Department of Biochemistry, University of Ibadan, Ibadan, Nigeria;b Department of Biochemistry, Kampala International University, Western Campus, UgandaView further author information
,
Enor Magdalene Effionga Department of Biochemistry, University of Ibadan, Ibadan, NigeriaView further author information
,
Patrick Maduabuchi Ajab Department of Biochemistry, Kampala International University, Western Campus, Uganda;c Department of Biochemistry, Ebonyi State University, Abakaliki, NigeriaView further author information
&
Chinaza Godswill Awuchib Department of Biochemistry, Kampala International University, Western Campus, Uganda;d School of Natural and Applied Sciences, Kampala International University, P.O. Box 20000Kansanga, Kampala, UgandaCorrespondence[email protected] [email protected]
View further author information
Pages 359-388 | Received 27 Sep 2022, Accepted 06 Dec 2022, Published online: 03 Jan 2023

References

  • Picard, M.; McEwen, B. S. Psychological Stress and Mitochondria: A Systematic Review. Psychosomatic Med. 2018, 80, 141–153. DOI: 10.1097/PSY.0000000000000545.
  • Ferroni, P.; Barbanti, P.; Della-Morte, D.; Palmirotta, R.; Jirillo, E.; Guadagni, F. Redox Mechanisms in Migraine: Novel Therapeutics and Dietary Interventions. Antioxid. Redox Signal. 2018, 28, 1144–1183. DOI: 10.1089/ars.2017.7260.
  • Lawal, B.; Shittu, O. K.; Obiokpa, F. I.; Berinyuy, E. B.; Mohammed, H. African Natural Products with Potential Antioxidants and Hepatoprotectives Properties: A Review. Clinical Phytosci. 2016, 2–23. DOI: 10.1186/s40816-016-0037-0.
  • Kruk, J.; Hassan, Y. A.-E.; Kladna, A.; Jacquelyn, E. B. Oxidative Stress in Biological Systems and Its Relation with Pathophysiological Functions: The Effect of Physical Activity on Cellular Redox Homeostasis. Free Radical Res. 2019, 53(5), 497–521. DOI: 10.1080/10715762.2019.1612059.
  • Akram, M.; Hamid, A.; Khalil, A.; Ghaffar, A.; Tayyaba, N.; Saeed, A.; Ali, M.; Naveed, A. Review on Medicinal Uses, Pharmacological, Phytochemistry and Immunomodulatory Activities of Plants. Int. J. Immunopathol. Pharmacol. 2014, 27(3), 313–319. DOI: 10.1177/039463201402700301.
  • Akram, M.; Adetunji, C. O.; Mohiuddin, E.; Oladosun, T. O.; Ozolua, P.; Olisaka, F. N.; Egbuna, C.; Olugbenga, S. M.; Adetunji, J. B.; Hameed, L., et al. Prospects of Phytochemicals for the Treatment of Helminthiasis. In Neglected Tropical Diseases and Phytochemicals in Drug Discovery; Egbuna, C., Akram, M., Ifemeje, J. C., Eds.; Wiley: New Jersey, 2021; pp 199–223. DOI: 10.1002/9781119617143.ch7.
  • Khalid, W.; Arshad, M. S.; Aslam, N.; Mukhtar, S.; Rahim, M. A.; Ranjha, M. M. A. N.; Noreen, S.; Afzal, M. F.; Aziz, A.; Awuchi, C. G. Food Applications of Sorghum Derived Kafirins Potentially Valuable in Celiac Disease. Int. J. Food Prop. 2022, 25(1), 2348–2363. DOI: 10.1080/10942912.2022.2135532.
  • Kawamura, T.; Muraoka, I. Exercise-induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint. Antioxidants. 2018, 7(9), 119. DOI: 10.3390/antiox7090119.
  • Gbadegesin, M. A.; Adegoke, A. M.; Ewere, E. G.; Odunola, O. A. Hepatoprotective and Anticlastogenic Effects of Ethanol Extract of Irvingia Gabonesis (IG) Leaves in Sodium arsenate-induced Toxicity in Male Wistar Rats. Niger. J. Physiol. Sci. 2014, 2, 029–36.
  • Adesanoye, O.; Farombi, E. In Vitro Antioxidant Properties of Methanolic Leaf Extract of Vernonia Amygdalina Del. Nigerian J. Physiological Sci. 2014, 29, 93–101.
  • Voituron, Y.; Josserand, R.; Le Galliard, J.-F.; Haussy, C.; Roussel, D.; Romestaing, C.; Meylan, S., et al. Chronic Stress, Energy Transduction, and free-radical Production in a Reptile. Oecologia. 2017, 185(2), 195–203. https://doi.org/10.1007/s00442-017-3933-1
  • Akinmoladun, A. C.; Obuotor, E. M.; Farombi, E. O. Evaluation of Antioxidant and Free Radical Scavenging Capacities of Some Nigerian Indigenous Medicinal Plants. J. Med. Food. 2010, 13, 444–451. DOI: 10.1089/jmf.2008.0292.
  • Usunobun, U.; Okolie, N. P.; Anyanwu, O. G.; Adegbegi, A. J. J.; Egharevba, M. E. Phytochemical Screening and Proximate Composition of Annona Muricata Leaves. Eur J.Botany, Plant Sci and Phytology. 2015, 2, 18–28.
  • Atta, A.; Mustafa, G.; Sheikh, M. A.; Shahid, M.; Xiao, H. The Biochemical Significances of the Proximate, Mineral and Phytochemical Composition of Selected Vegetables from Pakistan./Mat. Sc. Pharm. 2017, 1(1), 06–09.
  • Berma, S.; Singh, D.; Verma, P.; Soni, D.; Gupta, A.; Nema, R. Review Article Boerhavia Diffusa: An Important Medicinal Plant and Their Phytochemistry. CMBT J. Sci.Tech. 2013, 1(1), 01–04.
  • Bouzid, M. A.; Filaire, E.; Matran, R.; Robin, S.; & Fabre, C., et al. Lifelong Voluntary Exercise Modulates age-related Changes in Oxidative Stress. Int. J. Sports. Med. 2018, 39(1), 21–28. https://doi.org/10.1055/s-0043-119882
  • Khan, M. S.; Ansari, I. A.; Ahmad, S.; Akhtar, F.; Hashim, A.; Srivastava, A. K. Chemotherapeutic Potential of Boerhaavia Diffusa Linn; A Review. J. Applied Pharmaceutical Sci. 2013, 3(1), 133–139.
  • Yu, Y.; Gao, Q.; Xia, W.; Zhang, L.; Hu, Z.; Wu, X.; Jia, X., et al. Association between Physical Exercise and Biomarkers of Oxidative Stress among middle-aged and Elderly Community Residents with Essential Hypertension in China. Biomed Res. Int. 2018, 2018, 4135104. DOI: 10.1155/2018/4135104.
  • Sen, S.; De, B.; Devanna, N.; Chakraborty, R. Total Phenolic, Total Flavonoid Content, and Antioxidant Capacity of the Leaves of Meyna Spinosa Roxb., an Indian Medicinal Plant. Chinese J. Nat. Med. 2013, 11, 149–157. DOI: 10.1016/S1875-5364(13)60042-4.
  • Tufail, T.; Ijaz, A.; Noreen, S.; Arshad, M. U.; Gilani, S. A.; Bashir, S.; Din, A.; Shahid, M. Z.; Khan, A. A.; Khalil, A. A., et al. Pathophysiology of Obesity and Diabetes. In Dietary Phytochemicals; Egbuna, C., Hassan, S., Eds.; Springer: Cham, 2021; pp 29–42. DOI: 10.1007/978-3-030-72999-8_2.
  • Yasmin, I.; Khan, W. A.; Naz, S.; Iqbal, M. W.; Awuchi, C. G.; Egbuna, C.; Hassan, S.; Patrick-Iwuanyanwu, K. C.; Uche, C. Z. Etiology of Obesity, Cancer, and Diabetes. In Dietary Phytochemicals; Egbuna, C., Hassan, S., Eds.; Springer: Cham, 2021; pp 1–27. DOI: 10.1007/978-3-030-72999-8_1.
  • Goodarzi, S.; Rafiei, S.; Javadi, M.; Khadem, H. H.; Norozi, S. A. A Review on Antioxidants and Their Health Effects. J. Nutr. Food Secur. 2018, 3(2), 106–112.
  • Yasueda, A.; Urushima, H.; Ito, T. Efficacy and Interaction of Antioxidant Supplements as Adjuvant Therapy in Cancer Treatment: A Systematic Review. Int. Cancer. Therapies. 2016, 15(1), 17–39. DOI: 10.1177/1534735415610427.
  • Awuchi, C. G.; Okpala, C. O. R. Natural Nutraceuticals, Especially Functional Foods, Their Major Bioactive Components, Formulation, and Health Benefits for Disease Prevention - an Overview. J. Food Bioactives. 2022, 19. DOI: 10.31665/JFB.2022.18317.
  • Khaled, R. Medicinal Plants with Antioxidant Potential: A Review. Hygeia.J.D.Med. 2014, 6(1), 106–110. DOI: 10.15254/H.J.D.Med.6.2014.127.
  • Cheng, K.; Song, Z. H.; Zheng, X. C.; Zhang, H.; Zhang, J. F.; Zhang, L. L.; Zhou, Y. M.; Wang, T., et al. Effects of Dietary Vitamin E Type on the Growth Performance and Antioxidant Capacity in Cyclophosphamide Immunosuppressed Broilers. Poultr. Sci. 2017, 96(5), 1159–1166. https://doi.org/10.3382/ps/pew336
  • Lai, G. Y.; Weinstein, S. J.; Taylor, P. R.; McGlynn, K. A.; Virtamo, J.; Gail, M. H.; Albanes, D.; Freedman, N. D., et al. Effects of a-tocopherol and ß-carotene Supplementation on Liver Cancer Incidence and Chronic Liver Disease Mortality in the ATBC Study. Br. j. cancer. 2014, 111(12), 2220–2223. https://doi.org/10.1038/bjc.2014.514
  • Al-Asmari, A.; khan, A.; Al-Asmari, S.; Al-Rawi, A.; Al-Omani, S. Alleviation of the 5-flurouracil-induced Intestinal Mucositis in Rats by Vitamin E via Targeting Oxidative Stress and Inflammatory Markers. J. Complement. Integr. Med. 2016, 13(4), 377–385. DOI: 10.1515/jcim-2016-0043.
  • Finley, J. W.; Kong, A.-N.; Hintze, K. J.; Jeffery, E. H.; Ji, L. L.; Lei, X. G., et al. Antioxidants in Foods: State of the Science Important to the Food Industry. J. Agric. Food Chem. 2011, 59(13), 6837–6846. https://doi.org/10.1021/jf2013875
  • Bahadoran, Z.; Mirmiran, P.; Azizi, F. The Role of Dietary Polyphenols in Reducing Cardiovascular Complications in Type 2 Diabetes: A Review of Studies. J. Pejouhandeh. 2013, 18(1), 1–7.
  • Alin, J.; Hakkarainen, M. Microwave Heating Causes Rapid Degradation of Antioxidants in Polypropylene Packaging, Leading to Greatly Increased Specific Migration to Food Stimulants as Shown by ESI-MS and GC-MS. J. Agric. Food Chem. 2011, 59(10), 5418–5427. DOI: 10.1021/jf1048639.
  • Ofoedu, C. E.; Ofoedu, E. O.; Chacha, J. S.; Owuamanam, C. I.; Efekalam, I. S.; Awuchi, C. G.; Pandiselvam, R. Comparative Evaluation of Physicochemical, Antioxidant, and Sensory Properties of Red Wine as Markers of Its Quality and Authenticity. Int. J. Food Sci. 2022, 2022(8368992), 1–17. DOI: 10.1155/2022/8368992.
  • Ahmed, Y. C.; Rokiah, H.; Shaida, F. S.; Othman, S.; Zpa, L.; Kheng, L. O. Bioprospecting Medicinal Plants for Antioxidant Components. Asian Pac. J. Trop Med. 2014, 7(Suppl 1), 5553–5559. DOI: 10.1016/S1995-7645(14)60289-3.
  • Rahim, M. A.; Umar, M.; Habib, A.; Imran, M.; Khalid, W.; Lima, C. M. G.; Shoukat, A.; Itrat, N.; Nazir, A.; Ejaz, A., et al. Photochemistry, Functional Properties, Food Applications, and Health Prospective of Black Rice. J. Chem. 2022, 2022, 1–21. DOI: 10.1155/2022/2755084.
  • Atia, A. E.; Abdullah, A. Modulation of Nrf2/Keap1 Pathway by Dietary Phytochemicals. Int. J. Res. Med. Sci. 2014, 2, 375–381. DOI: 10.5455/2320-6012.ijrms20140501.
  • Ahaotu, N. N.; Echeta, C. K.; Bede, N. E.; Awuchi, C. G.; Anosike, C. L.; Ibeabuchi, C. J.; Ojukwu, M. Study on the Nutritional and Chemical Composition of “Ogiri” Condiment Made from Sandbox Seed (Hura Crepitans) as Affected by Fermentation Time. GSC Bio. Pharmaceutical Sciences. 2020, 11(2), 105–113. DOI: 10.30574/gscbps.2020.11.2.0115.
  • Mahantesh, S. P.; Gangawane, A. K.; Patil, C. S. Free Radicals, Antioxidants, Diseases and Phytomedicines in Human Health: Future Perspects. World Res. J. Med. Aromatic Plants. 2012, 1(1), 6–10.
  • Awuchi, C. G.; Twinomuhwezi, H.,2021. The Medical, Pharmaceutical, and Nutritional Biochemistry and Uses of Some Common Medicinal Plants. In Medicinal and Aromatic Plants of the World, Eds., Ozturk, M., Ameenah, G. F. B., Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of UNESCO, ELOSS Publishers, Paris, France, 1–32pp. Available at https://www.eolss.net/Sample-Chapters/C03/E6-79a-14.pdf (accessed May 25, 2022).
  • Zahnit, W.; Smara, O.; Bechki, L.; Souici, C. B.; Messaoudi, M.; Benchikha, N.; Larkem, I.; Awuchi, C. G.; Sawicka, B.; Simal-Gandara, J. Phytochemical Profiling, Mineral Elements, and Biological Activities of Artemisia Campestris L. Grown in Algeria. Horticulturae. 2022, 8(10), 914. DOI: 10.3390/horticulturae8100914.
  • Prakash, D.; Upadhyay, G.; Pushpangadan, P.; Gupta, C. Antioxidant and Free Radical Scavenging Activities of Some Fruits. J. Complement. Integr. Med. 2011, 8(1). DOI: 10.2202/1553-3840.1513.
  • Palai, S.; Kesh, S. S.; Awuchi, C. G.; Surajudeen, A. A.; Egbuna, C. Role of Phytochemicals in the Treatment of Ectoparasitic Infections: Scabies and Myiasis. In Neglected Tropical Diseases and Phytochemicals in Drug Discovery; Egbuna, C., Akram, M., Ifemeje, J. C., Eds.; Wiley: New Jersey, 2021; pp 477–498. DOI: 10.1002/9781119617143.ch20.
  • Nazer, M. R.; Abbaszadeh, S.; Anbari, K.; Shams, M. A Review of the Most Important Medicinal Herbs Affecting Giardiasis. J. Herbmed Pharmacol. 2019, 8(2), 78–84. DOI: 10.1517/jhp.2019.13.
  • Khatoon, U.; Sharma, L.; Dubey, R. K. Assessment of Bioactive Compounds, Antioxidant Activity and Quantification of Phenols through HPLC in Solanum Species. Ethno. Med. 2018, 12(2), 87–95.
  • Karamac, M.; Gal, F.; Longato, E.; Meineri, G.; Janiak, M. A.; Peiretti, P. G.; Peiretti, P. G. Antioxidant Activity and Phenolic Composition of Amaranth (Amaranth Spp.) during Plant Growth. Antioxidants. 2019, 8, 173. DOI: 10.3390/antiox8060173.
  • Lawal, B.; Ossai, P. C.; Shittu, O. K.; Abubakar, A. N. Evaluation of Phytochemicals, Proximate, Minerals and anti-nutritional Compositions of Yam Peel, Maize Chaff and Bean Coat. Int. J. Appl. Biol. Res. 2014, 6, 21–37.
  • Park, Y. J.; Baek, S.; Choi, Y.; Kim, J. K.; Park, S. U. Metabolic Profiling of Nine Mentha Species and Prediction of Their Antioxidant Properties Using Chemometrics. Molecules. 2019, 24, 258. DOI: 10.3390/molecules24020258.
  • Morya, S.; Awuchi, C. G.; Menaa, F. Advanced Functional Approaches of Nanotechnology in Food and Nutrition. In Environmental Management Technologies: Challenges and Opportunities; Chowdhary, P., Kumar, V., Hare, V., Eds.; CRC Press. Taylor & Francis: New York, 2022a; pp 257–272. DOI: 10.1201/9781003239956-16.
  • Adetutu, A.; Sinbad, O. O.; Bukoye, O. E. Phytpchemical Composition, Antioxidant Properties and Antibacterial Activities of Five West-African Green Leafy Vegetables. Senta. Acad. Pub. Brit. Col. 2013, 7, 2357–2362.
  • Nana, F. W.; Hilou, A.; Millogo, J. F.; Nacoulma, O. G. Phytochemical Composition, Antioxidant and Xanthine Oxidase Inhibitory Activities of Amaranthus Cruentus L. and Amaranthus Hybridus L. Extracts. Pharmaceuticals. 2012, 5, 613–628. DOI: 10.3390/ph5060613.
  • Amabye, T. G. Evaluation of Physicochemical, Phytochemical, Antioxidant Screening Parameters of Amaranthus Spp. Leaves. Nat Prod Chem Res. 2015, 4, 199. DOI: 10.4172/2329-6836.1000199.
  • Muniz-Marquez, D. B.; Rodriguez, R.; Balagurusamy, N.; Carrillo, M. L.; Belmares, R.; Contreras, J. C.; Nevarez, G. V. Phenolic Content and Antioxidant Capacity of Extracts of Laurus Nobilis L., Coriandrum Sativum and Amaranthus Hybridus L. J. Food. 2014, 12(3), 271–276. DOI: 10.1080/19476337.2013.847500.
  • Duangjan, C.; Rangsinth, P.; Zhang, S.; Wink, M.; Tencomnao, T. Anacardium Occidentale L. Leaf Extracts Protect against Glutamate/H2O2-Induced Oxidative Toxicity and Induce Neurite Outgrowth: The Involvement of SIRT1/Nrf2 Signaling Pathway and Teneurin 4 Transmembrane Protein. Front. Pharmacol. 2021, 12, 627738. DOI: 10.3389/fphar.2021.627738.
  • Souza, N. C.; de Oliveira, J. M.; Morrone, M. D. S.; Albanus, R. D.; Amarante, M. D. S. M.; Camillo, C. D. S.; Langassner, S. M. Z.; Gelain, D. P.; Moreira, J. C. F.; Dalmolin, R. J. S., et al. Antioxidant and Anti-Inflammatory Properties of Anacardium Occidentale Leaf Extract. Evid. Based Complement. Alternat. Med. 2017, 2017, 2787308. DOI: 10.1155/2017/2787308.
  • Baptista, A. B.; Sarandy, M. M.; Gonçalves, R. V.; Novaes, R. D.; Gonçalves da Costa, C.; Leite, J. P. V.; Peluzio, M. D. C. G. Antioxidant and Anti-Inflammatory Effects of Anacardium Occidentale L. and Anacardium Microcarpum D. Extracts on the Liver of IL-10 Knockout Mice. Evid. Based Complement. Alternat. Med. 2020, 2020, 3054521. DOI: 10.1155/2020/3054521.
  • Wani, S.; Basir, S. F. Analysis of Antioxidant Acitivity, Total Phenolic and Total Flavonoid Contents of Allium Sativum, Mentha Arvensis and Murraya Koenigii. Int. J. Adv. Res.Sci and Eng. 2018, 7(4), 2632–2646 .
  • Benkeblia, N. Free-Radical Scavenging Capacity and Antioxidant Properties of Some Selected Onions (Allium Cepa L.,) and Garlic (Allium Sativium L.) Extracts. Braz. Arch. Biol. Technol. 2005, 48(5), 753–759. DOI: 10.1590/S1516-89132005000600011.
  • Alara, O. R.; Abdurahman, N. H.; Abdul Mudalip, S. K.; Olalere, O. A. Effect of Drying Methods on the Free Radicals Scavenging Activity of Vernonia Amygdalina Growing in Malaysia. J.King Saud University – Sci. 2019, 31(4), 495–499. DOI: 10.1016/j.jksus.2017.05.018.
  • Imafidon, C. E.; Akomolafe, R. O.; Sanusi, A. A.; Ogundipe, O. J.; Olukiran, O. S.; Ayowole, O. A. Polyphenol-rich Extract of Vernonia Amygdalina (Del.) Leaves Ameliorated cadmium-induced Alterations in Feeding Pattern and Urine Volume of Male Wistar Rats. J. Intercultural Ethnopharmacol. 2015, 4, 4. DOI: 10.5455/jice.20151107021034.
  • Oluwaseun, R. A.; Nour, H. A.; Siti, K. A. M.; Olusegun, A. O. Characterization and Effect of Extraction Solvents on the Yield and Total Phenolic Content from Vernonia Amygdalina Leaves. Food Meas. 2017. DOI: 10.1007/s11694-017-9642-y.
  • Habtamu, A.; Melaku, Y. Antibacterial and Antioxidant Compounds from the Flower Extracts of Vernonia Amygdalina. Adv. Pharmacol. Sci. 2018, 2018, 1–6. DOI: 10.1155/2018/4083736.
  • Foo, R. Q.; Manogram, E.; Gabriel, A. A. Antimicrobial and Antioxidant Studies of Vernonia Amygdalina. J. App. Pharm. 2014, 6(4), 360–371.
  • Laulloo, S. J.; Bhowon, M. G.; Soyfoo, S.; Chua, L. S. Nutrional and Biological Evaluation of Leaves of Mangifera Indica from Mauritius. J. Chem. 2018, 2018. DOI: 10.1155/2018/6869294.
  • Erukainure, O. L.; Oke, O. V.; Owolabi, F. O.; Kayode, F. O.; Umanhonlen, E. E.; Aliyu, M. Chemical Properties of Mondora Myristica and Its Protective Potentials against Free Radicals in Vitro. Oxidants and Antioxidants in Medical Sci. 2012, 1(2), 127–132. DOI: 10.5455/oams.080712.or.009.
  • Nwakaego, N. L.; Chibuike, O. K.; Chukwugekwu, E. M.; Marylyn, A. C.; Ngozi, E. I.; Chukwunonye, E. R. In Vitro Antioxidant and Free Radical Scavenging Potential of Methanolic Extracts of Uvaria Chamae Leaves and Roots. Int. J. Pharm. Pharm. Sci. 2018, 11(1), 2019. DOI: 10.22159/ijpps.2019v11i1.29330.
  • Iwu, I. C.; Oze, R. N.; Onu, U. L.; Onwumere, F.; Ukaoma, A. A. Characterization of the Volatile Components and Antimicrobial Properties of the Ethanol Leaf Extract of Uvaria Chamae Grown in Eastern Nigeria. Int. J. Herbs, Species and Medicinal Plants. 2019, 4(2), 050–057.
  • Esekhiagbe, M.; Agatemor, M. U.; Agatemor, C. Phenolic Content and Antimicrobial Potentials of Xylopia Aethiopica and Myristica Argentea. Macedonian J. Chem. Eng. 2009, 28(2), 159–162. DOI: 10.20450/mjcce.2009.205.
  • Oso, B.; Oladiji, A. Total Phenolic Contents and Antioxidants Variations in Raw and Cooked Dried Fruit of Xylopia Aethiopica. Int. Ann. Sci. 2019, 6(1), 13–17. DOI: 10.21467/ias.6.1.13-17.
  • Habu, J. B.; Ibeh, B. O. Invitro Antoxidant Capacity and Free Radical Scavenging Evaluation of Activie Metabolite Constituents of Newbouldia Laevis Ethanolic Leaf Extract. Biol. Res. 2015, 48, 16. DOI: 10.1186/s40659-015-0007-x.
  • Ogunmoyole, T.; Olalekan, O. O.; Fatai, O.; Makun, J. O.; Kade, I. J. Antioxidant and Phytochemical Profile of Aqueous and Ethanolic Extract of Garcinia Kola. J. Pharmacognosy and Phytotherapy. 2012, 4(5), 66–74.
  • Okoko, T. In Vitro Antioxidant and Free Radical Scavenging Activities of Garcinia Kola Seeds. Food Chem. Toxicol. 2009, 47(10), 2620–2623. DOI: 10.1016/j.fct.2009.07.023.
  • Gulumian, M.; Yahaya, E. S.; Steenkamp, V. African Herbal Remedies with Antioxidant Activity: A Potential Resource Base for Wound Treatment. Evid. Based Complement. Altern. Med. 2018, 2018, 58. DOI: 10.1155/2018/4089541.
  • Jimoh, T. O. Enzymes Inhibitory and Radical Scavenging Potentials of Two Selected Tropical Vegetable (Moringa Oleifera and Telifaira Occidentalis) Leaves Relevant to Type 2 Diabetes Mellitus. Revista. Brasieira. De. Farmacognosia. 2018, 28(2018), 73–79. DOI: 10.1016/j.bjp.2017.04.003.
  • Swati, K.; Shivam, P. Total Phenolics and Flavonoid Content of the Leaves of Carica Papaya and Syzygium Cumini. World J Pharm. Res. 2018, 7(14), 734–741.
  • Maisarah, A. M.; Nurul Amira, B.; Asmah, R.; Fauziah, O. Antioxidant Analysis of Different Parts of Carica Papaya. Int. Food Res. J. 2013, 20(3), 1043–1048.
  • Sheneni, V. D.; Onoja, A. O.; Edegbo, E.; Momoh T. B., et al. In-vitro Antioxidant Activities of Ocimum Gratissimum, Vitex Doniana, Carica Papaya and Peristrophe Bicalyculata Using DPPH Free Radical Scavenging Activity. J. Nutr Health Food Eng.2018, 8(6), 371–375. DOI: 10.15406/jnhfe.2018.00298.
  • Kavitha, K. Evaluation of Total Phenols, Total Flavonoids, Antioxidant and Anticancer Activity of Mucuna Puriens Seed Extract. Asian J. Pharm. Clin. Res. 2018, 11(3), 242–246.
  • Agbafor, K. N.; Nwachukwu, N. Phytochemical Analysis and Antioxidant Property of Leaf Extracts of Vitex Doniana and Mucuna Pruriens. Biochem. Res. Int. 2011, 2011, 459839. DOI: 10.1155/2011/459839.
  • Ganiyu, O. Antioxidant and Antimicrobial Properties of Ethanolic Extract of Ocimium Gratissimum Leaves. J. Pharmacology and Toxicology. 2006, 1(1), 47–53.
  • Igbinosa,; Igbinosa, E. O.; Uzunuigbe, E. O.; Igbinosa, I. H.; Odjadjare, E. E.; Igiehon, N. O.; Emuedo, O. A., et al. In Vitro Assessment of Antioxidant, Phytochemical and Nutritional Properties of Extracts from the Leaves of Ocimum Gratissimum (Linn). Afr. J. Tradit Complement Altern Med.2013, 10(5), 292–298. DOI: 10.4314/aitcam.v10i5.11.
  • Gedikoglu, A.; Sokmen, M.; Civit, A. Evaluation of Thymis Vulgaris and Thymbra Spicata Essential Oils and Plant Extracts for Chemical Composition, Antioxidant and Antimicrobial Properties. Food Sci. Nutr. 2019, 2019(7), 1704–17174. DOI: 10.1002/fsn3.1007.
  • Shukia, R. K.; Porval, A.; Shukia, A.; Painuly, D.; Singh, J.; Kumar, V.; Bhutiani, R.; Vats, S. Phytochemical Screening, Total Phenolic Content Determination and Antimicrobial Activity of Ocimum Gratissimum Root. J. Chem. Pharm. Res. 2015, 7(8), 1052–1056.
  • Patil, S. M.; Ramu, R.; Shirahatti, P. S.; Shivamallu, C.; Amachawadi, R. G. A Systematic Review on Ethnopharmacology, Phytochemistry and Pharmacological Aspects of Thymus Vulgaris Linn. Heliyon. 2021, 7(5), e07054. DOI: 10.1016/j.heliyon.2021.e07054.
  • Mahmoodi, M.; Ayoobi, F.; Aghaei, A.; Rahmani, M.; Taghipour, Z.; Hosseini, A.; Jafarzadeh, A.; Sankian, M. Beneficial Effects of Thymus Vulgaris Extract in Experimental Autoimmune Encephalomyelitis: Clinical, Histological and Cytokine Alterations. Biomed. Pharmacother. 2019, 109, 2100–2108. DOI: 10.1016/j.biopha.2018.08.078.
  • Cruz, S. M.; Marroquin, N.; Alvarez, L. E.; Chang, D. E.; Caceres, A. Evaluation of Mangrove (Rhizophora Mangle L.) Products as Coloring, Antimicrobial and Antioxidant Agents. Int. J. Phyto and Natural Ingredients. 2015, 2, 12. DOI: 10.15171/ijpni.2015.12.
  • Miranti, D. I.; Ichiura, H.; Ohtani, Y. The Bioactive Compounds and Antioxidant Activity of Food Products of Rhizophora Stylosa Fruit (Coffee and Tea Mangrove). Int.J. Forestry Res. 2018, 2018, 1–6. DOI: 10.1155/2018/2315329.
  • Sanchez, J. C.; Garcia, R. F.; Cors, T. M. 1,1-Diphenyl-2-picrylhydrazyl Radical and Superoxide Anion Scavenging Activity of Rhizophora Mangle (L.) Bark. Pharmacogn. Res. 2010, 2(5), 279–284. DOI: 10.4103/0976-4836.72323.
  • Gbasemzadeh, A.; ZE, J. H.; Rahmat, A. Antioxidant Activities, Total Phenolics and Flavonoids Content in Two Varieties of Malaysia Young Ginger (Zingiber Officinale Roscoe). Molecules. 2010, 15, 4324–4333. DOI: 10.3390/molecules15064324.
  • Mao, Q.; Xu, X.; Cao, S.; Gan, R.; Corke, H.; Beta, T.; Li, H. Bioactive Compounds and Bioactivities of Ginger (Zingiber Officinale Roscoe). Foods. 2019, 8, 185. DOI: 10.3390/foods8060185.
  • Eletta, O. A. A.; Orimolade, B. O.; Oluwaniyi, O. O.; Dosimu, O. O. Evaluation of Proximate and Antioxidant Activities of Ethiopian Egg Plant (Solanium Aethiopicum L.) and Gboma Eggplant (Solanium Macrocarpon L). J. Appl. Sci. Environ. Manage. 2017, 21(5), 967–972.
  • Gaafar, A. A.; Nooman, M. U.; Ibrahim, E. A.; Ali, M. M.; Al-kashef, A. S. Prophylactic and Therapeutic Uses of Egyptian Mentha Spicata L., Mentha Piperita L. and Ocimum Basilicum L. Stalks as Agro-Industrial by Products. J. Bio. Sci. 2018, 18(7), 354–363. DOI: 10.3923/jbs.354-363.
  • Aliyu, A. B.; Ibrahim, H.; Musa, A. M.; Ibrahim, M. A.; Oyewale, A. O.; Amupitan, J. O. In Vitro Evaluation of Antioxidant Activity of Anisopus Mannii N.E. Br. African J. Biotechnology. 2010, 9(16), 2437–2441.
  • Sivakumar, D.; Chen, L.; Sultanbawa, Y. A. Comprehensive Review on Beneficial Dietary Phytochemicals in Common Traditional Southern African Leafy Vegetables. Food Sci. Nutr. 2018, 2018(6), 714–727. DOI: 10.1002/fsn3.643.
  • Salehi, B.; Gültekin-Özgüven, M.; Kirkin, C.; Özçelik, B.; Morais-Braga, M. F. B.; Carneiro, J. N. P.; Bezerra, C. F.; Silva, T. G. D.; Coutinho, H. D. M.; Amina, B., et al. Anacardium Plants: Chemical,Nutritional Composition and Biotechnological Applications. Biomolecules. 2019, 9(9), 465. DOI: 10.3390/biom9090465.
  • Ajileye, O. O.; Obuotorb, E. M.; Akinkunmic, E. O.; Aderogbaa, M. A. Isolation and Characterization of Antioxidant and Antimicrobial Compounds from Anacardium Occidentale L. (Anacardiaceae) Leaf Extract. J. King Saud Univ. Sci. 2015, 27(3), 244–252. DOI: 10.1016/j.jksus.2014.12.004.
  • Safar Harandi, M. M.; Dalimi Asl, A.; Ghaffarifar, F. In Vitro and in Vivo Effects of Garlic (Allium Sativum) Extract on Giardia Lamblia and Giardia Muris. Hakim. Res. J. 2006, 9(3), 58–64.
  • Moutia, M.; Habti, N.; Badou, A. In Vitro and in Vivo Immunomodulator Activities of Allium Sativum L. Evid. Based Complement. Altern. Med. 2018, 2018, 1–10. DOI: 10.1155/2018/4984659.
  • Farombi, E. O.; Owoeye, O. Antioxidative and Chemoprotective Properties of Vernonia Amygdalina and Garcinia Biflavonoid. Int. J. Environ. Res. Public Health. 2011, 8, 2533–2555. DOI: 10.3390/ijerph8062533.
  • Palafox-Carlos, H.; Yahia, E. M.; Gonzalez-Aguilar, G. A. Identification and Quantification of Major Phenolic Compounds from Mango Fruit (Mangifera Indica, Cv. Ataulfo) by HPLC-DAD-MS/MS-ESI and Their Individual Contribution to the Antioxidant Activity during Ripening. Food Chem. 2012, 135(1), 105–111. DOI: 10.1016/j.foodchem.2012.04.103.
  • Jahurul, M. H.; Zaidul, I. S.; Ghafoor, K.; Al-Juhaimi, F. Y.; Nyam, K.-L.; Norulaini, N. A. N.; Sahena, F.; Mohd Omar, A. K. Mango (Mangifera Indica L.) by-products and Their Valuable Components: A Review. Food Chem. 2015, 183, 173–180. DOI: 10.1016/j.foodchem.2015.03.046.
  • Kim, H.; Kim, H.; Mosaddik, A.; Gyawali, R.; Ahn, K. S.; Cho, S. K. Induction of Apoptosis by Ethanolic Extract of Mango Peel and Comparative Analysis of the Chemical Constitutes of Mango Peel and Flesh. Food Chem. 2012, 133(2), 416–422. DOI: 10.1016/j.foodchem.2012.01.053.
  • Rasoanaivo, R. H.; Albrieux, F.; Lemaire, M. Chemical Constituents of Peels, Kernels and Hulls of Fruits of Mangifera Indica Var. Hiesy and Their Potential Volarization. J. Pharmacogn. Phytochem. 2014, 3(4), 225–233.
  • Sani, H. L.; Malami, I.; Hassan, S. W.; Alhassan, M. A.; Halilu, E. M.; Muhammed, A. Effects of Standardized Stem Bark Extract of Mangifera Indica L. in Wistar Rats with 2,4-dinitrophenylhydrazine-induced Haemolytic Anaemia. Pharmacogn. J. 2015, 7(2), 89–96. DOI: 10.5530/pj.2015.2.2.
  • Ramirez, J. E.; Zambrano, R.; Sepulveda, B.; Simirgiotis, M. J. Antioxidant Properties and Hyphenated HPLC-PDA-MS Profiling of Chilean Pica Mango Fruits (Mangifera Indica L. Cv. Piqueno). Molecules. 2014, 19(1), 438–458. DOI: 10.3390/molecules19010438.
  • Dorta, E.; Gonzalez, M.; Gloria Lob, M.; Sanchez-Moreno, C.; Ancos, B. Screening of Phenolic Compounds in by-product Extracts from Mangoes (Mangifera Indica L.) by HPLC-ESI-QTOF-MS and Multivariate Analsysis for Use as a Food Ingredient. Food Res. Int. 2014, 57, 51–60. DOI: 10.1016/j.foodres.2014.01.012.
  • Shailajan, S.; Menon, S.; Kulkarni, S.; Tiwari, B. Standardized Extract of Mangifera Indica L. Leaves as an Immunomodulatory Agent. Pharmacognosy. Com. 2016, 6(3), 137–147. DOI: 10.5530/pc.2016.3.3.
  • Nguyen, H. X.; Van, T. N.; Do, T. H.; Nguyen, M. T. T.; Nguyen, N. T.; Esumi, H.; Awale, S. Chemical Constituents of Mangifera Indica and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line. J. Nat. Prod. 2016, 79(8), 2053–2059. DOI: 10.1021/acs.jnatprod.6b00381.
  • Ansari, A. H.; Ali, M.; Naquvi, K. J. New Manglanostenoic Acids from the Stem Bark of Mangifera Indica Var, Fazli. J. Saudi Chem. Soc. 2014, 18(5), 561–565. DOI: 10.1016/j.jscs.2011.11.003.
  • Feyisayo, A.; Oluokon, O. O. Comparative Analaysis of Phenolic Profile of Monodora Myristica and Monodora Tenuifolia. Afr. J. Agric. Res. 2014, 9(16), 1296–1302. DOI: 10.5897/AJA2012.7668.
  • Ofeimun, J. O.; Eze, G. I.; Okirika, O. M.; Uanseoje, S. O. Evaluation of the Hepatoprotective Effect of the Methanol Extract of the Root of Uvaria Afzelii (Annonaceae). J. Appl. Pharma. Sci. 2013, 3, 125–129.
  • Ita, B. N. Antioxidant Activity of Cnestis Ferruginea and Uvaria Chamae Seed Extracts. Br. J. Pharm. Res. 2017, 16(1), 1–8. DOI: 10.9734/BJPR/2017/32924.
  • Moukimou, A. O.; Pascal, A. D. C.; Annick, B.; Yaya, K.; Pierre, N. A. J.; Felicien, A.; Dominique, S. K. C. Chemical Characterization and Biological Activities of Extracts of Three Plants Used in Traditional Medicine in Benin: Tectona Grandis, Uvaria Chameae and Justicia Secunda. Asian J. Pharmacetuical and Clinical Res. 2014, 7(5), 2014.
  • Yin, X.; Chávez León, M. A. S. C.; Osae, R.; Linus, L. O.; Qi, L. W.; Alolga, R. N., 2019. Xylopia aethiopica Seeds from Two Countries in West Africa Exhibit Differences in Their Proteomes, Mineral Content and Bioactive Phytochemical Composition. Molecules, 24(10), 1979. Doi: 10.3390/molecules24101979.
  • Biney, R. P.; Benneh, C. K.; Ameyaw, E. O.; Boakye-Gyasi, E.; Woode, E. Xylopia Aethiopica Fruit Extract Exhibits antidepressant-like Effect via Interaction with Serotonergic Neurotransmission in Mice. J. Ethnopharmacol. 2016, 184, 49–57. DOI: 10.1016/j.jep.2016.02.023.
  • Kolodziej, H. Studies on Bignoniaceae: Newbouldiosides D - F, Minor Phenylethanoid Glycosides from Newbouldia Laevis, and New Flavonoids from Markhamia Zanzibarica and Spathodea Campanulata. Planta Med. 2021, 87(12–13), 989–997. DOI: 10.1055/a-1270-7761.
  • Aderogba, M. A.; Bezabih, M.; Abegaz, B. M. Antioxidant Constituents of Telifairia Occidentalis Leaf Extract. Ife J. Sci. 2008, 10(2) 268–271.
  • Kadiri, O.; Akanbi, C. T.; Olawoye, B. T.; Gbadamosi, S. O. Characterization and Antioxidant Evaluation of Phenolic Compounds Extracted from the Protein Concentrate and Protein Isolate Produced from Pawpaw (Carica Papaya Linn.) Seeds. Int. J. Food Prop. 2017, 20(11), 2423–2436. DOI: 10.1080/10942912.2016.1230874.
  • Bhavani, T.; Mohan, R. R.; Mounica, C.; Nyamisha, J.; Krishna, A. G.; Prabhavathi, P.; Raja, R. R.; Baba, K. K. Phytochemical Screening and Antimicrobial Activity of Ocimum Gratissimum Review. J. Pha. and Phytochemical. 2019, 8(2), 76–79.
  • Romero, A.; Forero, M.; Sequeda-Castaneda, L. G.; Grismaldo, A.; Iglesias, J.; Celis-Zambrano, C. A.; Schuler, I.; Morales, L. Effect of Ginger Extract on Membrane Potential Changes and AKT Activation on a peroxide-induced Oxidative Stress Cell Model. J. King Saud Univ. Sci. 2018, 30, 263–269. DOI: 10.1016/j.jksus.2017.09.015.
  • Peng, S.; Yao, J.; Liu, Y.; Duan, D.; Zhang, X.; Fang, J. Activation of Nrf2 Target Enzymes Conferring Protection against Oxidative Stress in PC12 Cells by Ginger Principal Constituent 6-shogaol. Food Funct. 2015, 6, 2813–2823. DOI: 10.1039/C5FO00214A.
  • Chen, H.; J, F.; Chen, H.; Y, H.; Soroka, D. N.; Prigge, J. R.; Schmidt, E. E.; Yan, F.; Major, M. B.; Chen, X., et al. Ginger Compound [6]-shogaol and Its cysteine-conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo. Chem. Res. Toxicol. 2014, 27, 1575–1585. DOI: 10.1021/tx500211x.
  • Saiah, W.; Halzoune, H.; Djaziri, R.; Tabani, K.; Koceir, E. A.; Omari, N. Antioxidant and Gastroprotectiveactions of Butanol Fraction of Zingiber Officinale against Diclofenac sodium-induced Gastric Damage in Rats. J. Food Biochem. 2018, 42, e12456. DOI: 10.1111/jfbc.12456.
  • Luettig, J.; Rosenthal, R.; Lee, I. M.; Krug, S. M.; Schulzke, J. D. The Ginger Component 6-shogaol Prevents TNF-alpha-induced Barrier Loss via Inhibition of P13K/Akt and NF-Kappa B Signaling. Mol. Nutr. Food Res. 2016, 2016, 2576–2586. DOI: 10.1002/mnfr.201600274.
  • Zubaida, Y.; Ying, W.; Elias, B. Phytochemistry and Pharmacological Studies on Solanum Torvum Swartz. J. Appl. Pharm. Sci. 2013, 3(4), 152–160. DOI: 10.7324/JAPS.2013.3428.
  • Musa, A. M.; Ibrahim, M. A.; Aliyu, A. B.; Abdullahi, M. S.; Tajuddeen, N.; Ibrahim, H.; Oyewole, A. O. Chemical Composition and Antimicrobial Activity of Hexane Leaf Extract of Anisopus Mannii (Asclepiadaceae). J. Intercultural Ethnopharmacol. 2015, 4; 2, 1338–1343. DOI: 10.5455/jice.20150106124652.
  • Awuchi, C. G.; Twinomuhwezi, H. Awuchi CG. 2022 Hyphenated Techniques. Egbuna, C., Patrick-Iwuanyanwu, K., Shah, M. A., Ifemeje, J. C., Rasul, A., Eds.; Analytical Techniques in Biosciences: From Basics to Applications. 125–145. Amsterdam, Netherlands: Elsevier, 10.1016/B978-0-12-822654-4.00015-4.
  • Kavitha, A.; Shanmugan, S.; Awuchi, C. G.; Kanagaraj, C.; Ravichandran, S. Synthesis and Enhanced Antibacterial Using Plant Extracts with Silver Nanoparticles: Therapeutic Application. Inorg. Chem. Commun. 2021, 134, 109045. DOI: 10.1016/j.inoche.2021.109045.
  • Natumanya, P.; Twinomuhwezi, H.; Igwe, V. S.; Maryam, S.; Awuchi, C. G. Effects of Drying Techniques on Nutrient Retention and Phytochemicals in Selected Vegetables. European J. Agri and Food Sci. 2021, 3(2), 5–14. DOI: 10.24018/ejfood.2021.3.2.247.
  • Sharma, S. K.; Singh, L.; Singh, S. A Review on Medicinal Plants Having Antioxidant Potential. J. Res. Pharmacy and Biotechnology. 2013, 1, 404.
  • Alara, O. R.; Abdul Mudalin, S. K.; Olalere, O. A. Optimization of Mangiferin Extracted from Phaleria Macrocarpa Fruits Using Response Surface Methodology. J. Appl. Res. Med. Aromat. Plants. 2017, 5, 82–87.
  • Ketsawatsakul, U.; Whiteman, M.; Halliwell, B. A Reevaluation of the Peroxynitriate Scavenging Activity of Some Dietary Phenolics. Biochem. Biophys. Res. Commun. 2000, 279, 692–699. DOI: 10.1006/bbrc.2000.4014.
  • Silva, M. M.; Santos, M. R.; Caroco, G.; Rocha, R.; Justino, G.; Mira, L. Structure- Antioxidant Acitivity Relationships of Flavonoids: A re-examinatiion. Free Radic. Res. 2002, 36, 1219–1227. DOI: 10.1080/198-1071576021000016472.
  • Halliwell, B. Antioxidant Activity and Other Biological Effects of Flavonoids. In Wake up to Flavonoids; Rice-Evans, C., Ed.; Royal Society of Medicine Press: London, 2000; Vol. 19, pp 13–23.
  • Furger, C. Live Cell Assays for the Assessment of Antioxidant Activities of Plant Extracts. Antioxidants. 2021, 10(6), 944. DOI: 10.3390/antiox10060944.
  • Madjitoloum, B. S.; Talla, E.; Nyemb, J. N.; Ngassoum, M. B.; Tsatsop Tsague, R. K.; Mahmout, Y. Comparative Survey of Three Processes Used for the Extraction of Total Phenol Content and Total Flavonoid Content of Anacardium Occidentale L. and the Assessment of Its Antioxidant Activity. Afr. J. Biotechnol. 2018, 17(40), 1265–1273. DOI: 10.5897/AJB2017.16294.
  • Zouari, C. R.; Snoussi, A.; Hamrouni, I.; Bouzouita, N. Chemical Composition, Antibacterial and Antioxidant Activities of Tunisian Garlic (Allium Sativum) Essential Oil and Ethanol Extract. Meditterranean J. Chem. 2014, 3, 947–956. DOI: 10.13171/mjc.3.4.2014.09.07.11.
  • Abdul Qadir, M.; Shahzadi, S. K.; Bashir, A.; Munir, A.; Shahzad, S. Evaluation of Phenolic Compounds and Antioxidant and Antimicrobial Activities of Some Common Herbs. Int. J. Analytical Chemi. 2017, 2017, 3475738. DOI: 10.1155/2017/3475738.
  • Awuchi, C. G. Medicinal Plants: The Medical, Food, and Nutritional Biochemistry and Uses. Int. J. Advanced Academic Res. 2019, 5(11), 220–241.
  • Egbuna, C.; Awuchi, C. G.; Kushwaha, E.; Rudrapal, M.; Patrick-Iwuanyanwu, K. C.; Singh, O.; Odoh, U. E.; Khan, J.; Jeevanandam, J.; Kumarasamy, S., et al. Bioactive Compounds Effective Against Type 2 Diabetes Mellitus: A Systematic Review. Curr. Topics. Med. Chem. 2021, 21, 1. DOI: 10.2174/1568026621666210509161059.
  • Awuchi, C. G. Medicinal Plants, Bioactive Compounds, and Dietary Therapies for Treating Type 1 and Type 2 Diabetes Mellitus [Online First. IntechOpen. 2021, Available from. DOI: 10.5772/intechopen.96470. (accessed June 04, 2022).
  • Nyarko, R. O.; Awuchi, C. G.; Kumar, R.; Boateng, E.; Kahwa, I.; Boateng, P. O.; Asum, C.; Saha, P. Effect of Calotropis Procera Extract on Appetitte, Body Weight & Lipid Profile in Cafeteria Diet Induced Obesity in Experimental Animal. J. Res. Applied Sci. Biotechnology. 2022, 1(3), 107–113. DOI: 10.55544/jrasb.1.3.14.
  • Adesanoye, O. A.; Farombi, E. O. Hepatoprotective Effects of Vernonia Amygdalina (Asteraceae) in Rats Treated with Carbon Tetrachloride. Exp. Toxicol. Pathol. 2010, 62, 197–206. DOI: 10.1016/j.etp.2009.05.008.
  • Eze-Steven, P. E.; Ishiwu, C. N.; Udedi, S. C.; Ogeneh, B. O. Evaluation of Antioxidant Potential of Monodora Myristica (African Nutmeg. Int. J. Curr. Microbiol. Appl. Sci. 2013, 2(11), 373–383.
  • Mohammed, A.; Shahidul, I. Antioxidant Potential of Xylopia Aethiopica Fruit Acetone Fraction in a Type 2 Diabetes Model of Rats. Biomed. Pharmacother. 2017, 96, 30–36. DOI: 10.1016/j.biopha.2017.09.116.
  • Nwozo, S. O.; Kasumu, F. T.; Oyinloye, E. B. African Nutmeg (Monodora Myristica) Lowers Cholesterol and Modulates Lipid Peroxidation in Experimentally Induced Hypercholesterolemic Male Wistar. Int. J. Biomed. Sci. 2015, 11, 86–92.
  • Womeni, H. M.; Tonfack, D. F.; Tiencheu, B.; Linder, M. Antioxidant Potential of Methanolic Extracts and Powders of Some Cameroonian Spices during Accelerated Storage of Soybean Oil. J. Advances in Biological Chem. 2013, 3, 304–313. DOI: 10.4236/abc.2013.33034.
  • Stephen, A. E.; Fred, O.; Uwadiae, E. Antimicrobial, Nutritional and Phytochemical Properties of Monodora Myristica Seeds. IOSR J. Pharm. Biol. Sci. 2012, 9(4 Ver. III), 01–06.
  • Owotokomo, I. A.; Ekundayo, O. Comparative Study of the Essential Oils of Monodora Myristica from Nigeria. Eur. Chem. Bull. 2012, 1(7), 263–265.
  • Sharififar, F.; Moshafi, M. H.; Dehghan- Nudehe, G.; Ameri, A.; Alishahi, F.; Pourhemati, A. Bioassay Screening of the Essential Oil and Various Extracts from Four Spices Medicinal Plants. Pak. J. Pharm. Sci. 2009, 22(3), 317–322.
  • Okpekon, T.; Millot, M.; Champy, P.; Gleye, C.; Yolou, S.; Bories, C.; Loiseau, P.; Laurens, A.; Hocquemiller, R., et al. A Novel 1-indanone Isolated from Uvaria Afzelii Roots. Nat. Prod. Res. 2009, 23(10), 909–915. DOI: 10.1080/14786410802497240.
  • Kayode, J.; Ige, O. E.; Adejogo, T. A.; Igbakin, A. A. Conservation and Biodiversity Erosion in Ondo State; Lagos state University Logos press: Nigeria, 2006; pp 53–64.
  • Anaduaka, E. G.; Ogugua, V. N.; Egba, S. I.; Apeh, V. O.; Simeon, I.; Victor, O. Investigation of Some Important Phytochemical, Nutritional Properties and Toxicological Potentials of Ethanol Extracts of Newbouldia Laevis Leaf and Stem. Afr. J. Biotechnol. 2013, 12, 5941–5949. DOI: 10.5897/AJB2013.12308.
  • Ejele, A.; Duru, I.; Ogukwe, C.; Iwu, I. Phytochemistry and Antimicrobial Potential of Basic Metabolites of Piper Umbellatum, Piper Guineense, Ocimum Gratissimium and Newbouldia Laevis Extracts. J. Emerg. Trends Eng. Appl. Sci. 2012, 3, 309–314.
  • Iwu, M. M.; Gbodossou, E. The Role of Traditional Medicine. Lancet. 2000, 356, S3. DOI: 10.1016/S0140-6736(00)91989-5.
  • Seun, A. A.; Sunday, I. O.; Tosin, A. O.; Ganiyu, O. Phenolic Characterization, Antioxidant Activities and Inhibitory Effects of Physalis Angulata and Newbouldia Laevis on Enzymes Linked to Erectile Dysfunction. Int. J. Food Prop. 2018, 21(1), 645–654. DOI: 10.1080/10942912.2018.446149.
  • Kayode, A. A. A.; Kayode, O. T. Some Medicinal Values of Telifaira Occidentalis. American J.Biochem. and Mol. Bio. 2011, 1(1), 30–39. DOI: 10.3923/ajbmb.2011.30.38.
  • Hasibuan, P. A. Z.; Harahap, U.; Sitorus, P.; Satria, D. (2020). The Anticancer Activities of Vernonia Amygdalina Delile. Leaves on 4T1 Breast Cancer Cells Through Phosphoinositide 3-Kinase (PI3K) Pathway. Heliyon, 6(7), e04449. DOI: 10.1016/j.heliyon.2020.e04449.
  • Awuchi, C. G.; Amagwula, I. O. The Biochemistry, Toxicology, and Uses of the Pharmacologically Active Phytochemicals: Alkaloids, Terpenes, Polyphenols, and Glycosides. Merit Res. J. Food Sci.Technology. 2020, 5(1), 006–021. DOI: 10.5281/zenodo.3967809.
  • Oboh, G. Antioxidative Potential of Ocimum Gratissimum and Ocimum Canum Leaf Polyphenols and Protective Effects on Some pro-oxidants Induced Lipid Peroxidation in Rat Brain: An in Vitro Study. American. J. Food.Technol. 2008, 3, 325–334. DOI: 10.3923/ajft.2008.325.334.
  • Zeghad, N.; Merghem, R. Antioxidant and Antibacterial Activities of Thymus Vulgaris L. Med. Aro. Plant. Res. J. 2013, 1(1), 5–11.
  • Yeshi, K.; Turpin, G.; Jamtsho, T.; Wangchuk, P. Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants. Molecules. 2022, 27(12), 3849. DOI: 10.3390/molecules27123849.
  • Boubekeur, S.; Messaoudi, M.; Awuchi, C. G.; Otekunrin, O.; Sawicka, B.; Idjeri-Mecherara, S.; Bouchareb, S.; Hassani, A.; Sharifi-Rad, M.; Begaa, S., et al. Biological Properties and Polyphenols Content of Algerian Cistus Salviifolius L. Aerial Parts. Eur J Biol Res. 2022, 12(2), 163–180. DOI: 10.5281/zenodo.6561505.
  • Sarvarian, M.; Jafarpour, A.; Awuchi, C. G.; Adeleye, A. O.; Okpala, C. O. R. Changes in Physicochemical, Free Radical Activity, Total Phenolic and Sensory Properties of Orange (Citrus Sinensis L.) Juice Fortified with Different Oleaster (Elaeagnus Angustifolia L.) Extracts. Molecules. 2022, 27, 1530. DOI: 10.3390/molecules27051530.
  • Xu, D. P.; Li, Y.; Meng, X.; Zhou, T.; Zhou, Y.; Zheng, J.; Zhang, J. J.; Li, H. B. Natural Antioxidants in Foods and Medicinal Plants: Extraction, Assessment and Resources. Int. J. Mol. Sci. 2017, 18(1), 96. DOI: 10.3390/ijms18010096.
  • Messaoudi, M.; Rebiai, A.; Sawicka, B.; Atanassova, M.; Ouakouak, H.; Larkem, I.; Egbuna, C.; Awuchi, C. G.; Boubekeur, S.; Ferhat, M. A., et al. Effect of Extraction Methods on Polyphenols, Flavonoids, Mineral Elements, and Biological Activities of Essential Oil and Extracts of Mentha Pulegium L. Molecules. 2022, 27(1), 11. DOI: 10.3390/molecules27010011.
  • Rafiq, S.; Sofi, S. A.; Kumar, H.; Kaul, R. K.; Mehra, R.; Awuchi, C. G.; Okpala, C. O. R.; Korzeniowska, M. Physicochemical, Antioxidant, and Polyphenolic Attributes of Microencapsulated freeze-dried Kinnow Peel Extract Powder Using Maltodextrin as Wall Material. J. Food Process. Preserv. 2022, 46(1), e16177. DOI: 10.1111/jfpp.16177.
  • Awuchi, C. G.; Akram, M.; Awuchi, C. G. Roles of Medicinal Plants in the Diagnosis and Treatment of Eumycetoma. In Neglected Tropical Diseases and Phytochemicals in Drug Discovery; Egbuna, C., Akram, M., Ifemeje, J. C., Eds.; Wiley: New Jersey, 2021; pp 453–476. DOI: 10.1002/9781119617143.ch19.
  • Stéphane, F. F. Y.; Jules, B. K. J.; Batiha, G. E.; Ali, I.; Bruno, L. N., 2021. Extraction of Bioactive Compounds from Medicinal Plants and Herbs. In Natural Medicinal Plants. London, United Kingdom: IntechOpen, 1–39 pp. DOI: 10.5772/intechopen.98602.
  • Zhang, Q. W.; Lin, L. G.; Ye, W. C. Techniques for Extraction and Isolation of Natural Products: A Comprehensive Review. Chin. Med. 2018, 13, 20. DOI: 10.1186/s13020-018-0177-x.
  • Twinomuhwezi, H.; Awuchi, C. G.; Kahunde, D. Extraction and Characterization of Pectin from Orange (Citrus Sinensis), Lemon (Citrus Limon) and Tangerine (Citrus Tangerina). American J. Phy. Sci. 2020, 1(1), 17–30.
  • Morya, S.; Awuchi, C. G.; Chowdhary, P.; Goyal, S. K.; Menaa, F. Ohmic Heating as an Advantageous Technology for the Food Industry. In Environmental Management Technologies: Challenges and Opportunities; Chowdhary, P., Kumar, V., Kumar, V., Hare, V., Eds.; CRC Press. Taylor & Francis: New York, 2022b; pp 307–327. DOI: 10.1201/9781003239956-19.
  • Usman, I.; Hussain, M.; Imran, A.; Afzaal, M.; Saeed, F.; Javed, M.; Afzal, A.; Ashfaq, I.; Al Jbawi, E.; Shamaail, A. S. Traditional and Innovative Approaches for the Extraction of Bioactive Compounds. Int. J. Food Prop. 2022, 25(1), 1215–1233. DOI: 10.1080/10942912.2022.2074030.

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