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International Journal of Food Properties Volume 26, 2023 - Issue 1
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Review Article

Anticancer and apoptosis inducing potential of quercetin against a wide range of human malignancies

Muhammad Shahbaza Department of Food Science and Technology, Muhammad Nawaz Shareef University of Agriculture, Multan, Pakistan
,
Hammad Naeema Department of Food Science and Technology, Muhammad Nawaz Shareef University of Agriculture, Multan, Pakistan
,
Ushna Momala Department of Food Science and Technology, Muhammad Nawaz Shareef University of Agriculture, Multan, Pakistan
,
Muhammad Imranb Department of Food Science and Technology, University of Narowal, Narowal, Pakistan
,
Suliman A. Alsagabyc Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, AL-Majmaah, Saudi Arabia
,
Waleed Al Abdulmonemd Department of Pathology, College of Medicine, Qassim University, Buraidah, Kingdom of Saudi Arabia
,
Ahmed Bilal Waqare University Institute of Medical Laboratory Technology, Faculty of Allied Health Sciences, University of Lahore, Lahore, Pakistan
,
Ahmed H. El-Ghorabf Department of Chemistry, College of Science, Jouf University, Sakaka, Saudi Arabia
,
Mohammed M. Ghoneimg Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah, Saudi Arabia;h Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
,
Mohamed A. Abdelgawadi Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia
,
Mohamed E. Shakerj Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi Arabia;k Department of Pharmacology & Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
,
Maryam Umarl Department of Food Science, Government College University Faisalabad, Faisalabad, Pakistan
,
Muzzamal Hussainl Department of Food Science, Government College University Faisalabad, Faisalabad, PakistanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-6508-1962
ORCID Icon,
Roshan Kumarm Department of Pharmacology, Guru Nanak College of Pharmaceutical Sciences, Dehradun, Uttarakhand, IndiaCorrespondence[email protected]
&
Entessar Al Jbawin Agricultural Extension Directorate, MAAR, Damascus, SyriaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1804-1770
ORCID Icon show all
Pages 2590-2626 | Received 15 May 2023, Accepted 22 Aug 2023, Published online: 07 Sep 2023

References

  • Abdu, S.; Juaid, N.; Amin, A.; Moulay, M.; Miled, N. Effects of Sorafenib and Quercetin Alone or in Combination in Treating Hepatocellular Carcinoma: In Vitro and In Vivo Approaches. Molecules. Nov 21, 2022, 27(22), DOI: 10.3390/molecules27228082. PMID: 36432184; PMCID: PMC9697794.
  • Adami, B. S.; Diz, F. M.; Oliveira Gonçalves, G. P.; Reghelin, C. K.; Scherer, M.; Dutra, A. P.; Papaléo, R. M.; de Oliveira, J. R.; Morrone, F. B.; Wieck, A., et al. Morphological and mechanical changes induced by quercetin in human T24 bladder cancer cells. Micron. Dec, 2021, 151, 103152. DOI: 10.1016/j.micron.2021.103152. Epub 2021 Sep 23. PMID: 34607251.
  • Ahmadi, M.; Valizadeh, A.; Bazavar, M.; Yousefi, B. Investigating the role of quercetin in increasing the rate of cisplatin-induced apoptosis via the NF-Κb pathway in MG-63 cancer cells. Drug Res. (Stuttg). Sep, 2022, 72(7), 385–389. DOI: 10.1055/a-1842-7424. Epub 2022 Jul 4. PMID: 35785813
  • Alam, S.; Mohammad, T.; Padder, R. A.; Hassan, M. I.; Husain, M. Thymoquinone and quercetin induce enhanced apoptosis in non-small cell Lung cancer in combination through the Bax/Bcl2 cascade. J. Cell. Biochem. Feb, 2022, 123(2), 259–274. DOI: 10.1002/jcb.30162. Epub 2021 Oct 12. PMID: 34636440.
  • Alban, L.; Monteiro, W. F.; Diz, F. M.; Miranda, G. M.; Scheid, C. M.; Zotti, E. R.; Morrone, F. B.; Ligabue, R. New quercetin-coated titanate nanotubes and their radiosensitization effect on human bladder cancer. Mater. Sci. Eng. C Mater. Biol. Appl. May, 2020, 110, 110662. DOI: 10.1016/j.msec.2020.110662. Epub 2020 Jan 15. PMID: 32204090.
  • Ali, A.; Kim, M. J.; Kim, M. Y.; Lee, H. J.; Roh, G. S.; Kim, H. J.; Cho, G. J.; Choi, W. S. Quercetin induces cell death in cervical cancer by reducing O-GlcNAcylation of adenosine monophosphate-activated protein kinase. Anat. Cell Biol. Dec, 2018, 51(4), 274–283. DOI: 10.5115/acb.2018.51.4.274. Epub 2018 Dec 29. PMID: 30637162; PMCID: PMC6318463
  • Almeida, A. F.; Borge, G. I.; Piskula, M.; Tudose, A.; Tudoreanu, L.; Valentová, K.; Williamson, G.; Santos, C. N. Bioavailability of quercetin in humans with a Focus on Interindividual Variation. Compr. Rev. Food Sci. Food Saf. May, 2018, 17(3), 714–731. DOI: 10.1111/1541-4337.12342.
  • Amiri, A.; Abbasi, A.; Dehghani, M.; Ramezani, A.; Ramezani, F.; Zal, F.; Mostafavi-Pour, Z. New perspectives of quercetin and Vitamin C effects on fibronectin-binding integrins and chemokine receptors in prostate cancer cell lines. Bratisl. Lek. Listy. 2021, 122(7), 507–512. PMID: 34161119. DOI: 10.4149/BLL_2021_082.
  • Andres, S.; Pevny, S.; Ziegenhagen, R.; Bakhiya, N.; Schäfer, B.; Hirsch-Ernst, K. I.; Lampen, A. Safety aspects of the use of quercetin as a dietary supplement. Mol. Nutr. Food Res. Jan, 2018, 62(1), 1700447. DOI: 10.1002/mnfr.201700447.
  • Ansari, M. A. Anticancer potential of quercetin: a comprehensive review. Phytother. Res. Sep, 2019, 33(9): 2065–2086.
  • Asgharian, P.; Tazehkand, A. P.; Soofiyani, S. R.; Hosseini, K.; Martorell, M.; Tarhriz, V.; Ahangari, H.; Cruz-Martins, N.; Sharifi-Rad, J.; Almarhoon, Z. M., et al.Quercetin impact in pancreatic cancer: an overview on Its therapeutic effects. OXID. MED. CELL LONGEV. Nov 3, 2021, 4393266. DOI: 10.1155/2021/4393266. PMID: 34777687; PMCID: PMC8580629
  • Asgharian, P.; Tazekand, A. P.; Hosseini, K.; Forouhandeh, H.; Ghasemnejad, T.; Ranjbar, M.; Hasan, M.; Kumar, M.; Beirami, S. M.; Tarhriz, V., et al. Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets. Cancer. Cell Inter. Aug 15, 2022, 22(1), 257. DOI: 10.1186/s12935-022-02677-w.
  • Antoni, S.; Ferlay, J.; Soerjomataram, I.; Znaor, A.; Jemal, A.; Bray, F. Bladder cancer incidence and mortality: a global overview and recent trends. Europ. urol. Jan 1, 2017, 71(1), 96–108. DOI: 10.1016/j.eururo.2016.06.010.
  • Azeem, M.; Hanif, M.; Mahmood, K.; Ameer, N.; Chughtai, F. R.; Abid, U. An insight into anticancer, antioxidant, antimicrobial, antidiabetic and anti-inflammatory effects of quercetin: a review. Polym. Bull. Jan, 2023, 80(1), 241–262. DOI: 10.1007/s00289-022-04091-8.
  • Azizi, E.; Fouladdel, S.; Komeili Movahhed, T.; Modaresi, F.; Barzegar, E.; Ghahremani, M. H.; Ostad, S. N.; Atashpour, S. Quercetin effects on cell cycle arrest and apoptosis and doxorubicin activity in T47D cancer stem cells. Asian Pac. J. Cancer Prev. Dec 1, 2022, 23(12), 4145–4154. DOI: 10.31557/APJCP.2022.23.12.4145. PMID: 36579996; PMCID: PMC9971456.
  • Bakoyiannis, I.; Daskalopoulou, A.; Pergialiotis, V.; Perrea, D. Phytochemicals and cognitive health: are flavonoids doing the trick? Biomed. Pharmacother. Jan 1, 2019, 109, 1488–1497. DOI: 10.1016/j.biopha.2018.10.086.
  • Baruah, M. M.; Khandwekar, A. P.; Sharma, N. Quercetin modulates wnt signaling components in prostate cancer cell line by inhibiting cell viability, migration, and metastases. Tumour Biol. Oct, 2016, 37(10), 14025–14034. Doi: 10.1007/s13277-016-5277-6. Epub 2016 Aug 5. PMID: 27495232.
  • Baghel, S. S.; Shrivastava, N.; Baghel, R. S.; Agrawal, P.; Rajput, S. A review of quercetin: antioxidant and anticancer properties. World J Pharm Pharmaceutical Sci. May 1, 2012, 1(1), 146–160.
  • Benito, I.; Encío, I. J.; Milagro, F. I.; Alfaro, M.; Martínez-Peñuela, A.; Barajas, M.; Marzo, F. Microencapsulated bifidobacterium bifidum and lactobacillus gasseri in combination with quercetin inhibit colorectal cancer development in ApcMin/+ Mice. Int. J. Mol. Sci. May 5, 2021, 229, 4906. DOI: 10.3390/ijms22094906. PMID: 34063173; PMCID: PMC8124226.
  • Bhatiya, M.; Pathak, S.; Jothimani, G.; Duttaroy, A. K.; Banerjee, A. A comprehensive study on the anti-cancer effects of quercetin and its epigenetic modifications in arresting progression of colon cancer cell proliferation. Arch Immunol Ther Exp (Warsz). Feb 20. 2023, 71(1), 6. DOI: 10.1007/s00005-023-00669-w. PMID: 36807774; PMCID: PMC9941246.
  • Cao, Y.; Zhang, W.; Chen, X.; Chen, J.; Wang, X.Quercetin as a potential anticancer agent: from biology to clinical application.Cancer Lett. May 28. 2021, 505, 9–20.
  • Çelik, H.; Arinç, E. Evaluation of the protective effects of quercetin, rutin, naringenin, resveratrol and trolox against idarubicin-induced DNA damage.
  • Chai, R.; Xu, C.; Lu, L.; Liu, X.; Ma, Z. Quercetin inhibits proliferation of and induces apoptosis in non-small-cell lung carcinoma via the lncRna Snhg7/miR-34a-5p pathway. Immunopharmacol. Immunotoxicol. Dec, 2021, 43(6), 693–703. DOI: 10.1080/08923973.2021.1966032. Epub 2021 Aug 27. PMID: 34448661.
  • Chan, C. Y.; Hong, S. C.; Chang, C. M.; Chen, Y. H.; Liao, P. C.; Huang, C. Y. Oral squamous cell carcinoma cells with acquired resistance to erlotinib are sensitive to anti-cancer effect of quercetin via pyruvate kinase M2 (PKM2). Cells. Jan 1. 2023, 12(1), 179. DOI: 10.3390/cells12010179. PMID: 36611972; PMCID: PMC9818869.
  • Chaudhari, V. S.; Gawali, B.; Saha, P.; Naidu, V. G. M.; Murty, U. S.; Banerjee, S. Quercetin and piperine enriched nanostructured lipid carriers (NLCs) to improve apoptosis in oral squamous cellular carcinoma (FaDu Cells) with improved biodistribution profile. Eur. J. Pharmacol. Oct 15. 2021, 909, 174400. DOI: 10.1016/j.ejphar.2021.174400. Epub 2021 Jul 29. PMID: 34332920.
  • Chen, B.; Li, X.; Wu, L.; Zhou, D.; Song, Y.; Zhang, L.; Wu, Q.; He, Q.; Wang, G.; Liu, X.et al.Quercetin suppresses human glioblastoma migration and invasion via GSK3β/β-Catenin/zeb1 signaling pathway.Front Pharmacol. Nov 1, 2022, 13, 963614. DOI: 10.3389/fphar.2022.963614. PMID: 36386155; PMCID: PMC9663482.
  • Chen, L.; Xia, J. S.; Wu, J. H.; Chen, Y. G.; Qiu, C. J. Quercetin suppresses cell survival and invasion in oral squamous cell carcinoma via the MiR-1254/CD36 cascade in vitro. Hum. Exp. Toxicol. Sep, 2021, 40(9), 1413–1421. DOI: 10.1177/0960327121991912. Epub 2021 Mar 9. PMID: 33686878.
  • Chen, W. J.; Tsai, J. H.; Hsu, L. S.; Lin, C. L.; Hong, H. M.; Pan, M. H. Quercetin blocks the aggressive phenotype of triple-negative breast cancer by inhibiting IGF1/Igf1R-mediated EMT program. J. Food Drug Anal. Mar 15. 2021, 29(1), 98–112. DOI: 10.38212/2224-6614.3090. PMID: 35696220; PMCID: PMC9261845
  • Chen, X.; Xu, P.; Zhang, H.; Su, X.; Guo, L.; Zhou, X.; Wang, J.; Huang, P.; Zhang, Q.; Sun, R. EGFR and ERK Activation resists flavonoid quercetin-induced anticancer activities in human cervical cancer cells in vitro. Oncol. Lett. Nov, 2021, 22(5), 754. DOI: 10.3892/ol.2021.13015. Epub 2021 Aug 31. PMID: 34539858; PMCID: PMC8436358
  • Cirmi, S.; Ferlazzo, N.; Lombardo, G. E., et al.Quercetin and cancer: biological implications and therapeutic potential.Front Pharmacol. Jul 3, 2020, 11, 1306.
  • Colpan, R. D.; Erdemir, A. Co-delivery of quercetin and caffeic-acid phenethyl ester by polymeric nanoparticles for improved antitumor efficacy in colon cancer cells. J. Microencapsul. Sep, 2021, 38(6), 381–393. DOI: 10.1080/02652048.2021.1948623. Epub 2021 Jul 5. PMID: 34189998.
  • Darband, S. G.; Sadighparvar, S.; Yousefi, B.; Kaviani, M.; Ghaderi-Pakdel, F.; Mihanfar, A.; Rahimi, Y.; Mobaraki, K.; Majidinia, M. Quercetin attenuated oxidative DNA damage through NRF2 Signaling pathway in rats with DMH induced colon carcinogenesis. Life. sci. Jul 15, 2020, 253, 117584. DOI: 10.1016/j.lfs.2020.117584. Epub 2020 Mar 24. PMID: 32220623.
  • David, A. V.; Arulmoli, R.; Parasuraman, S. Overviews of biological importance of quercetin: a bioactive flavonoid. Pharmacogn. Rev. Jul, 2016, 10(20), 84. DOI: 10.4103/0973-7847.194044.
  • Deepika, M. P. Health benefits of quercetin in age-related diseases. Molecules. Apr 13, 2022, 27(8), 2498. DOI: 10.3390/molecules27082498.
  • Dhanaraj, T.; Mohan, M.; Arunakaran, J. Quercetin attenuates metastatic ability of human metastatic ovarian cancer cells via modulating multiple signaling molecules involved in cell survival, proliferation, migration and adhesion. Arch. Biochem. Biophys Apr 15, 2021, 701, 108795. DOI: 10.1016/j.abb.2021.108795. Epub 2021 Feb 9. PMID: 33577840.
  • Elmowafy, M.; Shalaby, K.; Elkomy, M. H.; Alsaidan, O. A.; Gomaa, H. A. M.; Hendawy, O. M.; Abdelgawad, M. A.; Ali, H. M.; Ahmed, Y. M.; El-Say, K. M. Exploring the potential of quercetin/aspirin-loaded chitosan nanoparticles coated with eudragit l100 in the treatment of induced-colorectal cancer in rats. Drug. Deliv. Transl. Res. Mar 31, 2023, DOI: 10.1007/s13346-023-01338-3. Epub ahead of print. PMID: 37000409.
  • Elumalai, P.; Ezhilarasan, D.; Raghunandhakumar, S. Quercetin inhibits the epithelial to mesenchymal transition through suppressing akt mediated nuclear translocation of β-catenin in lung cancer cell line. Nutr. Cancer. 2022, 74(5), 1894–1906. DOI: 10.1080/01635581.2021.1957487. Epub 2021 Aug 2. PMID: 34338101.
  • Ersoz, M.; Erdemir, A.; Derman, S.; Arasoglu, T.; Mansuroglu, B. Quercetin-loaded nanoparticles enhance cytotoxicity and antioxidant activity on C6 glioma cells. Pharm. Dev. Technol. Jul, 25(6), 757–766. 2020, DOI: 10.1080/10837450.2020.1740933. Epub 2020 Mar 20. PMID: 32192406.
  • Ferreira, M.; Gomes, D.; Neto, M.; Passarinha, L. A.; Costa, D.; Sousa, Â. development and characterization of quercetin-loaded delivery systems for increasing its bioavailability in cervical cancer cells. Pharmaceutics Mar 14, 2023, 153, 936. DOI: 10.3390/pharmaceutics15030936. PMID: 36986797; PMCID: PMC10058887.
  • Fulfager, A. D.; Yadav, K. S. Understanding the Implications of co-delivering therapeutic agents in a nanocarrier to combat multidrug resistance (MDR) in breast cancer. J. Drug Delivery Sci. Technol. Apr 1, 2021, 62, 102405. DOI: 10.1016/j.jddst.2021.102405.
  • Ganthala, P. D.; Alavala, S.; Chella, N.; Andugulapati, S. B.; Bathini, N. B.; Sistla, R. Co-Encapsulated Nanoparticles of Erlotinib and Quercetin for Targeting Lung Cancer through Nuclear EGFR and PI3K/AKT Inhibition. Colloids Surf. B Biointerfaces. Mar, 2022, 211, 112305. DOI: 10.1016/j.colsurfb.2021.112305. Epub 2021 Dec 30. PMID: 34998178.
  • Gao, R.; Zhang, R.; Chen, T.; Zheng, Y.; Wang, G. Quercetin Suppresses Cancer Stem Cell Properties in Neuroblastoma Via Downregulation of Wnt/β-Catenin Signaling. Oncol. Rep. Aug, 2021, 46(2), 83. DOI: 10.3892/or.2021.8179.
  • García-Gutiérrez, N.; Luna-Bárcenas, G.; Herrera-Hernández, G.; Campos-Vega, R.; Lozano-Herrera, S. J.; Sánchez-Tusié, A. A.; García-Solis, P.; Vergara-Castañeda, H. A. Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-exposed HT-29 Colon Cancer Cells’ Viability. Int. J. Mol. Sci. Mar 2023, 15, 246, 5604. DOI: 10.3390/ijms24065604. PMID: 36982678; PMCID: PMC10052295.
  • Gaikwad, S.; Srivastava, S. K. Role of Phytochemicals in Perturbation of Redox Homeostasis in Cancer. Antioxidants. Jan 9, 2021, 10(1), 83. DOI: 10.3390/antiox10010083.
  • Golmohammadi, M.; Elmaghraby, D. A.; Ramírez-Coronel, A. A.; Rakhimov, N.; Mohammed, S. S.; Romero-Parra, R. M.; Jawad, M. A.; Zamanian, M. Y.; Soltani, A.; Taheri, N.et al. A Comprehensive View on the Quercetin impact on Bladder Cancer: Focusing on oxidative Stress, Cellular, And Molecular Mechanisms. Fundam. Clin. Pharmacol. Mar 24, 2023, DOI: 10.1111/fcp.12896. Epub ahead of print. PMID: 36960597
  • Gonçalves, C. F. L.; Hecht, F.; Cazarin, J.; Fortunato, R. S.; Vaisman, M.; Carvalho, D. P.; Ferreira, A. C. F.The Flavonoid Quercetin Reduces Cell Migration And Increases Nis And E-cadherin mRNA In The Human Thyroid Cancer Cell Line BCPAP. Mol. Cell. Endocrinol. Jun 1, 529,111266. DOI: 10.1016/j.mce.2021.111266. Epub 2021 Apr 6. PMID: 33831503.
  • Greco, S.; Islam, M. S.; Zannotti, A.; Delli Carpini, G.; Giannubilo, S. R.; Ciavattini, A.; Petraglia, F.; Ciarmela, P. Quercetin aNd Indole-3-carbinol Inhibit Extracellular Matrix Expression In Human Primary Uterine Leiomyoma Cells. Reprod Biomed Online. Apr, 2020, 40(4), 593–602. DOI: 10.1016/j.rbmo.2020.01.006. Epub 2020 Jan 23. PMID: 32276890.
  • Guo, H.; Ding, H.; Tang, X.; Liang, M.; Li, S.; Zhang, J.; Cao, J. Quercetin Induces Pro-apoptotic Autophagy Via Sirt1/AMPK Signaling Pathway In Human Lung Cancer Cell Lines A549 And H1299 In Vitro. Thorac Cancer. May, 2021, 12(9), 1415–1422. DOI: 10.1111/1759-7714.13925. Epub 2021 Mar 11. PMID: 33709560; PMCID: PMC8088950.
  • Guo, Y.; Tong, Y.; Zhu, H.; Xiao, Y.; Guo, H.; Shang, L.; Zheng, W.; Ma, S.; Liu, X.; Bai, Y. Quercetin Suppresses Pancreatic Ductal Adenocarcinoma Progression Via Inhibition Of Shh And Tgf-β/smad Signaling Pathways. Cell Biol. Toxicol. Jun, 2021, 37, 479–496. DOI: 10.1007/s10565-020-09562-0.
  • Guo, Y.; Tong, Y.; Zhu, H.; Xiao, Y.; Guo, H.; Shang, L.; Zheng, W.; Ma, S.; Liu, X.; Bai, Y. Quercetin Suppresses Pancreatic Ductal Adenocarcinoma Progression via Inhibition of SHH and TGF-Β/smad Signaling Pathways. Cell Biol. Toxicol. Jun, 2021, 37(3), 479–496. DOI: 10.1007/s10565-020-09562-0. Epub 2020 Oct 17. PMID: 33070227.
  • Hassan, S.; Peluso, J.; Chalhoub, S.; Idoux Gillet, Y.; Benkirane-Jessel, N.; Rochel, N.; Fuhrmann, G.; Ubeaud-Sequier, G.; Ulasov, I. Quercetin Potentializes the Respective Cytotoxic Activity of Gemcitabine or Doxorubicin on 3D Culture of AsPC-1 or HepG2 Cells, Through the Inhibition of HIF-1α and MDR1. PLoS One. Oct 14, 2020, 15(10), e0240676. DOI: 10.1371/journal.pone.0240676. PMID: 33052979; PMCID: PMC7556446.
  • Hai, Y.; Zhang, Y.; Liang, Y.; Ma, X.; Qi, X.; Xiao, J.; Xue, W.; Luo, Y.; Yue, T. Advance on the Absorption, Metabolism, and Efficacy Exertion of Quercetin and Its Important Derivatives: Absorption, Metabolism and Function of Quercetin. Food Front. Dec, 2020, 1(4), 420–434. DOI: 10.1002/fft2.50.
  • He, C.; Lu, X.; Li, J.; Shen, K.; Bai, Y.; Li, Y.; Luan, H.; Tuo, S. The Effect of Quercetin on Cervical Cancer Cells as Determined by Inducing Tumor Endoplasmic Reticulum Stress and Apoptosis and Its Mechanism of Action. Am. J. Transl. Res. May 15, 2021, 135, 5240–5247. PMID: 34150114; PMCID: PMC8205781
  • Hoca, M.; Becer, E.; Kabadayi, H.; Yucecan, S.; Vatansever, H. S. The Effect of Resveratrol and Quercetin on Epithelial-Mesenchymal Transition in Pancreatic Cancer Stem Cell. Nutr. Cancer. 2019, 1–12. DOI: 10.1080/01635581.2019.1670853.
  • Hoca, M.; Becer, E.; Kabadayı, H.; Yücecan, S.; Vatansever, H. S. The Effect of Resveratrol and Quercetin on Epithelial-Mesenchymal Transition in Pancreatic Cancer Stem Cell. Nutr. Cancer. Oct 2, 2020, 72(7), 1231–1242. DOI: 10.1080/01635581.2019.1670853.
  • Hong, Y.; Lee, J.; Moon, H.; Ryu, C. H.; Seok, J.; Jung, Y. S.; Ryu, J.; Baek, S. J. Quercetin Induces Anticancer Activity by Upregulating Pro-NAG-1/GDF15 in Differentiated Thyroid Cancer Cells. Cancers (Basel). Jun 16. 2021, 13(12), 3022. DOI: 10.3390/cancers13123022. PMID: 34208730; PMCID: PMC8233818
  • Hosseini, S. S.; Ebrahimi, S. O.; Haji Ghasem Kashani, M.; Reiisi, S. Study of Quercetin and Fisetin Synergistic Effect on Breast Cancer and Potentially Involved Signaling Pathways. Cell Biol. Int. Jan, 2023, 47(1), 98–109. DOI: 10.1002/cbin.11942. Epub 2022 Oct 23. PMID: 36273436.
  • Hussain, Y.; Mirzaei, S.; Ashrafizadeh, M.; Zarrabi, A.; Hushmandi, K.; Khan, H.; Daglia, M. Quercetin and Its Nano-Scale Delivery Systems in Prostate Cancer Therapy: Paving the Way for Cancer Elimination and Reversing Chemoresistance. Cancers. Mar 31, 2021, 13 7, 1602. DOI: 10.3390/cancers13071602.
  • Hu, M.; Song, H. Y.; Chen, L. Quercetin Acts via the G3BP1/YWHAZ Axis to Inhibit Glycolysis and Proliferation in Oral Squamous Cell Carcinoma. Toxicol. Mech. Methods. Feb, 2023, 33(2), 141–150. DOI: 10.1080/15376516.2022.2103480. Epub 2022 Aug 9. PMID: 35945655.
  • Huang, K. Y.; Wang, T. H.; Chen, C. C.; Leu, Y. L.; Li, H. J.; Jhong, C. L.; Chen, C. Y. Growth Suppression in Lung Cancer Cells Harboring EGFR-C797S Mutation by Quercetin. Biomolecules. Aug 25, 2021, 11(9), 1271. DOI: 10.3390/biom11091271. PMID: 34572484; PMCID: PMC8470952.
  • Huang, R., et al.Quercetin-Loaded Nanocarriers for Cancer Treatment: A Review.J. Control Release. Oct 28, 2016, 238, 89–113.
  • Huh, S.; Lee, S.; Choi, S. J.; Wu, Z.; Cho, J. H.; Kim, L.; Shin, Y. S.; Kang, B. W.; Kim, J. G.; Liu, K.et al. Quercetin Synergistically Inhibit EBV-Associated Gastric Carcinoma with Ganoderma Lucidum Extracts. Molecules. 2019 Oct 24, 2421, 3834. DOI: 10.3390/molecules24213834. PMID: 31653035; PMCID: PMC6864608.
  • Hyun, H. B.; Moon, J. Y.; Cho, S. K. Quercetin Suppresses CYR61-Mediated Multidrug Resistance in Human Gastric Adenocarcinoma AGS Cells. Molecules. Jan 24, 2018, 23(2), 209. DOI: 10.3390/molecules23020209. PMID: 29364834; PMCID: PMC6017870
  • Imran, M.; Salehi, B.; Sharifi-Rad, J., et al., Kaempferol: A Key Emphasis to Its Anticancer Potential. Molecules. Oct 7, 2019, 2419, 2277. DOI: 10.3390/molecules24122277
  • Ji, Y.; Li, L.; Ma, Y. X.; Li, W. T.; Li, L.; Zhu, H. Z.; Wu, M. H.; Zhou, J. R. Quercetin Inhibits Growth of Hepatocellular Carcinoma by Apoptosis Induction in Part via Autophagy Stimulation in Mice. J. NUTR BIOCHEM. Jul, 2019, 69, 108–119. DOI: 10.1016/j.jnutbio.2019.03.018. Epub 2019 Apr 8. PMID: 31078904; PMCID: PMC9659433.
  • Jing, D.; Wu, W.; Chen, X.; Xiao, H.; Zhang, Z.; Chen, F.; Zhang, Z.; Liu, J.; Shao, Z.; Pu, F. Quercetin Encapsulated in Folic Acid-Modified Liposomes is Therapeutic Against Osteosarcoma by Non-Covalent Binding to the JH2 Domain of JAK2 via the JAK2-STAT3-PDL1. Pharmacol. Res. Aug, 2022, 182, 106287. DOI: 10.1016/j.phrs.2022.106287. Epub 2022 Jun 6. PMID: 35671921.
  • Johnson, K. E.; Wilgus, T. A. Vascular Endothelial Growth Factor and Angiogenesis in the Regulation of Cutaneous Wound Repair. Advances In Wound Care. Oct 1, 2014, 3(10), 647–661. DOI: 10.1089/wound.2013.0517.
  • Kampa, R. P.; Gliździńska, A.; Szewczyk, A.; Bednarczyk, P.; Filipek, S. Flavonoid Quercetin Abolish Paxilline Inhibition of the Mitochondrial BKCa Channel. Mitochondrion. 2022, 65, 23–32. DOI: 10.1016/j.mito.2022.04.005.
  • Kedhari Sundaram, M.; Raina, R.; Afroze, N.; Bajbouj, K.; Hamad, M.; HaQuercetin, S.; Hussain, A. Quercetin Modulates Signaling Pathways and Induces Apoptosis in Cervical Cancer Cells. Biosci. Rep. Aug 13, 2019, 398, BSR20190720. DOI: 10.1042/BSR20190720. PMID: 31366565; PMCID: PMC6692570.
  • Kim, H. I.; Lee, S. J.; Choi, Y. J.; Kim, M. J.; Kim, T. Y.; Ko, S. G. Quercetin Induces Apoptosis in Glioblastoma Cells by Suppressing Axl/IL-6/STAT3 Signaling Pathway. Am. J. Chin. Med. 2021, 49(3), 767–784. DOI: 10.1142/S0192415X21500361. Epub 2021 Mar 3. PMID: 33657989.
  • Kim, S. R.; Lee, E. Y.; Kim, D. J.; Kim, H. J.; Park, H. R. Quercetin Inhibits Cell Survival and Metastatic Ability via the EMT-Mediated Pathway in Oral Squamous Cell Carcinoma. Molecules. Feb 10, 2020, 25(3), 757. DOI: 10.3390/molecules25030757. PMID: 32050534; PMCID: PMC7037689.
  • Kim, D. H.; Khan, H.; Ullah, H.; Hassan, S. T.; Šmejkal, K.; Efferth, T.; Mahomoodally, M. F.; Xu, S.; Habtemariam, S.; Filosa, R., et al. MicroRna Targeting by Quercetin in Cancer Treatment and Chemoprotection. Pharmacol. Res. Sep 1, 2019, 147, 104346. DOI: 10.1016/j.phrs.2019.104346.
  • Korkina, L. G.; Mikhalchik, E. V. Suppression of Human Prostate Cancer Cell Metastatic Potential by Quercetin Treatment: A Prelude to Antioxidant Therapy. Acta Naturae. Oct-Dec, 2016, 8(4): 121–126.
  • Kreczmer, B.; Dyba, B.; Barbasz, A.; Rudolphi-Szydło, E. Advantageous/Unfavorable Effect of Quercetin on the Membranes of SK-N-SH Neuroblastoma Cells. Molecules. Aug 16, 2021, 26(16), 4945. DOI: 10.3390/molecules26164945. PMID: 34443533; PMCID: PMC8397999.
  • Kubina, R.; Iriti, M.; Kabała-Dzik, A. Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers. Nutrients. Mar 5, 2021, 13(3), 845. DOI: 10.3390/nu13030845.
  • Kusaczuk, M.; Krętowski, R.; Naumowicz, M.; Stypułkowska, A.; Cechowska-Pasko, M. A Preliminary Study of the Effect of Quercetin on Cytotoxicity, Apoptosis, and Stress Responses in Glioblastoma Cell Lines. Int. J. Mol. Sci. Jan 25, 2022, 233, 1345. DOI: 10.3390/ijms23031345. PMID: 35163269; PMCID: PMC8836052.
  • Lan, C. Y.; Chen, S. Y.; Kuo, C. W.; Lu, C. C.; Yen, G. C. Quercetin Facilitates Cell Death and Chemosensitivity Through RAGE/PI3K/AKT/mTOR axis in Human Pancreatic Cancer Cells. J. Food Drug Anal. Oct, 2019, 27(4), 887–896. DOI: 10.1016/j.jfda.2019.07.001. Epub 2019 Aug 21. PMID: 31590760; PMCID: PMC9306979.
  • Lan, H.; Hong, W.; Fan, P.; Qian, D.; Zhu, J.; Bai, B. Quercetin Inhibits Cell Migration and Invasion in Human Osteosarcoma Cells. Cell. Physiol. Biochem. 2017, 43(2), 553–567. DOI: 10.1159/000480528. Epub 2017 Sep 21. PMID: 28965117.
  • Lee, H. H.; Lee, S.; Shin, Y. S.; Cho, M.; Kang, H.; Cho, H. Anti-Cancer Effect of Quercetin in Xenograft Models with EBV-Associated Human Gastric Carcinoma. Molecules. Sep 26. 2016, 21(10), 1286. DO: 10.3390/molecules21101286. PMID: 27681719; PMCID: PMC6274130.
  • Lee, J.; Han, S. I.; Yun, J. H.; Kim, J. H. Quercetin 3-O-Glucoside Suppresses Epidermal Growth Factor–Induced Migration by Inhibiting EGFR Signaling in Pancreatic Cancer Cells. Tumor Biol. Dec, 2015, 36(12), 9385–9393. DOI: 10.1007/s13277-015-3682-x.
  • Lee, Y. H.; Tuyet, P. T. Synthesis and Biological Evaluation of Quercetin-Zinc (II) Complex for Anti-Cancer and Anti-Metastasis of Human Bladder Cancer Cells. Vitro Cell Dev Biol Anim. Jun, 2019, 55(6), 395–404. DOI: 10.1007/s11626-019-00363-2. Epub 2019 May 14. PMID: 31089950.
  • Lei, C. S.; Hou, Y. C.; Pai, M. H.; Lin, M. T.; Yeh, S. L. Effects of Quercetin Combined with Anticancer Drugs on Metastasis-Associated Factors of Gastric Cancer Cells: In Vitro and In Vivo Studies. J. NUTR BIOCHEM. Jan, 2018, 51, 105–113. DOI: 10.1016/j.jnutbio.2017.09.011. Epub 2017 Sep 28. PMID: 29125991.
  • Lezcano, V.; Morelli, S.; González-Pardo, V. Molecular and Cellular Outcomes of Quercetin Actions on Healthy and Tumor Osteoblasts. Biochimie. Aug, 2022, 199, 46–59, DOI: 10.1016/j.biochi.2022.04.003. Epub 2022 Apr 18. PMID: 35447220.
  • Li, C.; Gao, L.; Zhang, Y.; Simpson, B. K. Preparation of Quercetin Loaded Microparticles and Their Antitumor Activity Against Human Lung Cancer Cells (A549) In Vitro. Curr. Pharm. Biotechnol. 2019, 20(11), 945–954. DOI: 10.2174/1573407215666190628145902. PMID: 31264544.
  • Li, Z. Y.; Chen, S. Y.; Weng, M. H. Ursolic Acid Restores Sensitivity to Gemcitabine Through the RAGE/NF-κB/MDR1 Axis in Pancreatic Cancer Cells and in a Mouse Xenograft Model. Journal Of Food And Drug Analysis. 2021, 29(2), 262. DOI: 10.38212/2224-6614.3346.
  • Li, H.; Tan, L.; Zhang, J. W.; Chen, H.; Liang, B.; Qiu, T.; Li, Q. S.; Cai, M.; Zhang, Q. H. Quercetin is the Active Component of Yang-Yin-Qing-Fei-Tang to Induce Apoptosis in Non-Small Cell Lung Cancer. Am. J. Chin. Med. 2019, 47(4), 879–893. DOI: 10.1142/S0192415X19500460. PMID: 31179723.
  • Li, S.; Pei, Y.; Wang, W.; Liu, F.; Zheng, K.; Zhang, X. Quercetin Suppresses the Proliferation and Metastasis of Metastatic Osteosarcoma Cells by Inhibiting Parathyroid Hormone Receptor 1. Biomed. Pharmacother. Jun, 2019, 114, 108839. DOI: 10.1016/j.biopha.2019.108839. Epub 2019 Apr 9. PMID: 30978523.
  • Li, X.; Zhu, Q.; Ma, M.; Guo, H. Quercetin Inhibits the Progression of Endometrial HEC-1-A Cells by Regulating Ferroptosis-A Preliminary Study. Eur. J. Med. Res. Dec 15, 2022, 27(1), 292. DOI: 10.1186/s40001-022-00934-2. PMID: 36522794; PMCID: PMC9753389
  • Li, Y.; Kou, J.; Wu, T.; Zheng, P.; Chao, X. Screening of Therapeutic Candidate Genes of Quercetin for Cervical Cancer and Analysis of Their Regulatory Network. Onco. Targets Ther. Feb 5, 2021, 14, 857–866. DOI: 10.2147/OTT.S287633. PMID: 33574679; PMCID: PMC7873026.
  • Li, Y.; Wang, Z.; Jin, J.; Zhu, S. X.; He, G. Q.; Li, S. H.; Wang, J.; Cai, Y. Quercetin Pretreatment Enhances the Radiosensitivity of Colon Cancer Cells by Targeting Notch-1 Pathway. Biochem. Biophys. Res. Commun Mar 19, 2020, 523(4), 947–953. DOI: 10.1016/j.bbrc.2020.01.048. Epub 2020 Jan 18. PMID: 31964531.
  • Li, Z.; Zhang, J.; Ren, X.; Liu, Q.; Yang, X. The Mechanism of Quercetin in Regulating Osteoclast Activation and the PAR2/TRPV1 Signaling Pathway in the Treatment of Bone Cancer Pain. Int. J. Clin. Exp. Pathol. Nov 1, 2018, 11(11), 5149–5156. PMID: 31949595; PMCID: PMC6963045.
  • Lin, R.; Piao, M.; Song, Y.; Liu, C. Quercetin Suppresses AOM/DSS-Induced Colon Carcinogenesis Through Its Anti-Inflammation Effects in Mice. J. Immunol. Res. May 21, 2020, 20(20), 1–10, DOI: 10.1155/2020/9242601. PMID: 32537472; PMCID: PMC7260625.
  • Lotfi, N.; Yousefi, Z.; Golabi, M.; Khalilian, P.; Ghezelbash, B.; Montazeri, M.; Shams, M. H.; Baghbadorani, P. Z.; Eskandari, N. The Potential Anti-Cancer Effects of Quercetin on Blood, Prostate and Lung Cancers: An Update. Front. Immunol. Feb 28, 2023, 14, 1077531. DOI: 10.3389/fimmu.2023.1077531.
  • Liu, X. H.; Pan, L. L.; Zhu, Y. Z. Active Chemical Compounds of Traditional Chinese Medicine Herba Leonuri: Implications for Cardiovascular Diseases. Clin. Exp. Pharmacol. Physiol. Mar, 2012, 39(3), 274–282. DOI: 10.1111/j.1440-1681.2011.05630.x.
  • Liu, G. Pharmacokinetics and Safety of Quercetin in Healthy Volunteers and Prostate Cancer Patients. J. Pharm. Pharmacol. Nov, 2016, 68(11): 1439–1447.
  • Luo, C. L.; Liu, Y. Q.; Wang, P.; Song, C. H.; Wang, K. J.; Dai, L. P.; Zhang, J. Y.; Ye, H. The Effect of Quercetin Nanoparticle on Cervical Cancer Progression by Inducing Apoptosis, Autophagy and Anti-Proliferation via JAK2 Suppression. Biomed. Pharmacother. Aug, 2016, 82, 595–605. DOI: 10.1016/j.biopha.2016.05.029. Epub 2016 Jun 9. PMID: 27470402.
  • Ma, Y. S.; Yao, C. N.; Liu, H. C.; Yu, F. S.; Lin, J. J.; Lu, K. W.; Liao, C. L.; Chueh, F. S.; Chung, J. G. Quercetin Induced Apoptosis of Human Oral Cancer SAS Cells Through Mitochondria and Endoplasmic Reticulum Mediated Signaling Pathways. Oncol. Lett. Jun, 2018, 15(6), 9663–9672. DOI: 10.3892/ol.2018.8584. Epub 2018 Apr 26. PMID: 29928342; PMCID: PMC6004715.
  • Maleki Dana, P.; Sadoughi, F.; Asemi, Z.; Yousefi, B. The Role of Polyphenols in Overcoming Cancer Drug Resistance: A Comprehensive Review. Cellular & Molecular Biology Letters. Dec, 2022, 27(1), 1–26. DOI: 10.1186/s11658-021-00301-9.
  • Malakoti, F.; Majidinia, M.; Ahmadi, Y.; Yousefi, B.; Shanebandi, D. Quercetin Augments Cisplatin-Induced Apoptosis, DNA Damage Response, and MiR-22 Expression While It Prevents DNA Repair in Osteosarcoma Cells. Drug Res. (Stuttg). Sep, 2022, 72(7), 378–384. DOI: 10.1055/a-1800-6030. Epub 2022 Jun 20. PMID: 35724673.
  • Marques, M. B.; Machado, A. P.; Santos, P. A.; Carrett-Dias, M.; Araújo, G. S.; da Silva Alves, B.; de Oliveira, B. S.; da Silva Júnior, F. M. R.; Dora, C. L.; Cañedo, A. D., et al. Anti-MDR Effects of Quercetin and Its Nanoemulsion in Multidrug-Resistant Human Leukemia Cells. ACAMC. 2021, 21(14), 1911–1920. DOI: 10.2174/1871520621999210104200722. PMID: 33397267.
  • Mebarek, S.; Skafi, N.; Brizuela, L. Targeting Sphingosine 1-Phosphate Metabolism as a Therapeutic Avenue for Prostate Cancer. Cancers. May 12, 2023, 15(10), 2732. DOI: 10.3390/cancers15102732.
  • Mohamed, A. A.; Zaghloul, R. A.; Abdelghany, A. M.; El Gayar, A. M. Selenium Nanoparticles and Quercetin Suppress Thioacetamide-Induced Hepatocellular Carcinoma in Rats: Attenuation of Inflammation Involvement. J. Biochem. Mol. Toxicol. Apr, 2022, 36(4), e22989. DOI: 10.1002/jbt.22989. Epub 2022 Feb 18. PMID: 35179263.
  • Mohammadi, E.; Alemi, F.; Maleki, M.; Malakoti, F.; Farsad-Akhtar, N.; Yousefi, B. Quercetin and Methotrexate in Combination Have Anticancer Activity in Osteosarcoma Cells and Repress Oncogenic MicroRNA-223. Drug Res. (Stuttg). Apr, 2022, 72(4), 226–233. DOI: 10.1055/a-1709-0658. Epub 2022 Apr 6. PMID: 35385884.
  • Mohammadpour, A. H., et al. Quercetin and Cancer: New Insights into Its Therapeutic Effects on Ovarian Cancer Cells. Cell. Mol. Biol. (Noisy-le-Grand). Oct 31, 2017, 6311. 121–126.
  • Momchilova, A.; Nikolaev, G.; Pankov, S.; Vassileva, E.; Krastev, N.; Robev, B.; Krastev, D.; Pinkas, A.; Pankov, R. Effect of Quercetin and Fingolimod, Alone or in Combination, on the Sphingolipid Metabolism in HepG2 Cells. Int. J. Mol. Sci. Nov 11, 2022, 2322, 13916. DOI: 10.3390/ijms232213916. PMID: 36430423; PMCID: PMC9697772.
  • Mousavi, N.; Rahimi, S.; Emami, H.; Kazemi, A. H.; Mohammad Taghi Kashi, R.; Heidarian, R. The Effect of Quercetin Nanosuspension on Prostate Cancer Cell Line LNCaP via Hedgehog Signaling Pathway. Rep Biochem Mol Biol. Apr, 2021, 10(1), 69–75. DOI: 10.52547/rbmb.10.1.69. PMID: 34277870; PMCID: PMC8279718.
  • Murata, M.; Komatsu, S.; Miyamoto, E.; Oka, C.; Lin, I.; Kumazoe, M.; Yamashita, S.; Fujimura, Y.; Tachibana, H. Quercetin Up-Regulates the Expression of Tumor-Suppressive microRnas in Human Cervical Cancer. Biosci. Microbiota Food Health. 2023, 42(1), 87–93. DOI: 10.12938/bmfh.2022-056. Epub 2022 Oct 5. PMID: 36660602; PMCID: PMC9816044.
  • Mutlu Altundağ, E.; Kasacı, T.; Yılmaz, A. M.; Karademir, B.; Koçtürk, S.; Taga, Y.; Yalçın, A. S. Quercetin-Induced Cell Death in Human Papillary Thyroid Cancer (B-CPAP) Cells. J Thyroid Res. 2016, 9843675. Epub 2016 Jan 20. PMID: 27057371; PMCID: PMC4745605. DOI: 10.1155/2016/9843675.
  • Mutlu Altundag, E.; Mine Yilmaz, A.; Kasaci, T.; Corek, C.; Taga, Y.; Suha Yalçin, A. The Role of HSP90 in Quercetin-Induced Apoptosis in Human Papillary Thyroid (B-CPAP) Cancer Cells. Free Radic Biol Med. Oct, 2014, 75(Suppl 1), S43. DOI: 10.1016/j.freeradbiomed.2014.10.797. Epub 2014 Dec 10. PMID: 26461378.
  • Mutlu Altundağ, E.; Yılmaz, A. M.; Serdar, B. S.; Jannuzzi, A. T.; Koçtürk, S.; Yalçın, A. S. Synergistic Induction of Apoptosis by Quercetin and Curcumin in Chronic Myeloid Leukemia (K562) Cells: II. Signal Transduction Pathways Involved. Nutr. Cancer. 2021, 73(4), 703–712. DOI: 10.1080/01635581.2020.1767167. Epub 2020 May 18. PMID: 32420759.
  • Naimi, A.; Entezari, A.; Hagh, M. F.; Hassanzadeh, A.; Saraei, R.; Solali, S. Quercetin Sensitizes Human Myeloid Leukemia KG-1 Cells Against TRAIL-Induced Apoptosis. J. Cell. Physiol. 2019, 234(8), 13233–13241. DOI: 10.1002/jcp.27995.
  • Nday, C. M.; Halevas, E.; Jackson, G. E.; Salifoglou, A. Quercetin Encapsulation in Modified Silica Nanoparticles: Potential Use Against Cu (II)-Induced Oxidative Stress in Neurodegeneration. J. Inorg. Biochem. Apr 1, 2015, 145, 51–64. DOI: 10.1016/j.jinorgbio.2015.01.001.
  • Nakhaee, S.; Farrokhfall, K.; Miri-Moghaddam, E.; Foadoddini, M.; Askari, M.; Mehrpour, O. The Effects of Quercetin on Seizure, Inflammation Parameters and Oxidative Stress in Acute on Chronic Tramadol Intoxication. BMC Pharmacology And Toxicology. Dec, 2021, 22(1), 1–1. DOI: 10.1186/s40360-021-00532-8.
  • Özgöçmen, M.; Bayram, D.; Armağan, İ.; Türel, G. Y.; Sevimli, M.; Şenol, N. Is Quercetin Beneficial for Colon Cancer? A Cell Culture Study, Using the Apoptosis Pathways. Anti Cancer Agents Med. Chem. 2022, 22(1), 193–200. DOI: 10.2174/1871520621666210624110547. PMID: 34170811.
  • Özsoy, S.; Becer, E.; Kabadayı, H.; Vatansever, H. S.; Yücecan, S. Quercetin-Mediated Apoptosis and Cellular Senescence in Human Colon Cancer. Anti Cancer Agents Med. Chem. 2020, 20(11), 1387–1396. DOI: 10.2174/1871520620666200408082026. PMID: 32268873.
  • Panche, A. N.; Diwan, A. D.; Chandra, S. R. Flavonoids: An Overview. J. Nutr. Sci. 2016, 5, 47. DOI: 10.1017/jns.2016.41.
  • Paranthaman, S.; Uthaiah, C. A.; Osmani, R. A. M.; Hani, U.; Ghazwani, M.; Alamri, A. H.; Fatease, A. A.; Madhunapantula, S. V.; Gowda, D. V. Anti-Proliferative Potential of Quercetin Loaded Polymeric Mixed Micelles on Rat C6 and Human U87MG Glioma Cells. Pharmaceutics. Aug 6. 2022, 14(8), 1643. DOI: 10.3390/pharmaceutics14081643. PMID: 36015268; PMCID: PMC9412540.
  • Pradhan, A.; Kumari, A.; Srivastava, R.; Panda, D. Quercetin Encapsulated Biodegradable Plasmonic Nanoparticles for Photothermal Therapy of Hepatocellular Carcinoma Cells. ACS Appl Bio Mater. Dec 16. 2019, 2(12), 5727–5738. DOI: 10.1021/acsabm.9b00764. Epub 2019 Nov 22. PMID: 35021566.
  • Qi, W.; Qi, W.; Xiong, D.; Long, M. Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy. Molecules. Oct 3, 2022, 27(19), 6545. DOI: 10.3390/molecules27196545.
  • Qiu, D.; Yan, X.; Xiao, X.; Zhang, G.; Wang, Y.; Cao, J.; Ma, R.; Hong, S.; Ma, M. To Explore Immune Synergistic Function of Quercetin in Inhibiting Breast Cancer Cells. Cancer Cell Int. Nov 27, 2021, 21(1), 632. DOI: 10.1186/s12935-021-02345-5. PMID: 34838003; PMCID: PMC8626953.
  • Ramalingam, V.; Muthukumar Sathya, P.; Srivalli, T.; Mohan, H. Synthesis of Quercetin Functionalized Wurtzite Type Zinc Oxide Nanoparticles and Their Potential to Regulate Intrinsic Apoptosis Signaling Pathway in Human Metastatic Ovarian Cancer. Life. sci. Nov 15, 2022, 309, 121022. DOI: 10.1016/j.lfs.2022.121022. Epub 2022 Oct 4. PMID: 36206836.
  • Rubió, L.; Motilva, M. J.; Romero, M. P. Recent Advances in Biologically Active Compounds in Herbs and Spices: A Review of the Most Effective Antioxidant and Anti-Inflammatory Active Principles. Critical Reviews in Food Science and Nutrition. Crit. Rev. Food Sci. Nutr. Jan 1, 2013, 53(9), 943–953. DOI: 10.1080/10408398.2011.574802.
  • Rubio, V.; García-Pérez, A. I.; Herráez, A.; Diez, J. C. Different Roles of Nrf2 and NFKB in the Antioxidant Imbalance Produced by Esculetin or Quercetin on NB4 Leukemia Cells. Chem. Biol. Interact. Oct 1, 2018, 294, 158–166. DOI: 10.1016/j.cbi.2018.08.015. Epub 2018 Aug 30. PMID: 30171828.
  • Russo, M.; Spagnuolo, C.; Tedesco, I.; Bilotto, S.; Russo, G. L. The Flavonoid Quercetin in Disease Prevention and Therapy: Facts and Fancies. Biochem. Pharmacol. 2012 Jan 1, 83(1), 6–15. DOI: 10.1016/j.bcp.2011.08.010.
  • Ryu, S.; Park, S.; Lim, W.; Song, G. Quercetin Augments Apoptosis of Canine Osteosarcoma Cells by Disrupting Mitochondria Membrane Potential and Regulating PKB and MAPK Signal Transduction. J. Cell. Biochem. Oct, 2019, 120(10), 17449–17458. DOI: 10.1002/jcb.29009. Epub 2019 May 26. PMID: 31131468.
  • Salama, Y. A.; El-Karef, A.; El Gayyar, A. M.; Abdel-Rahman, N. Beyond Its Antioxidant Properties: Quercetin Targets Multiple Signalling Pathways in Hepatocellular Carcinoma in Rats. Life. sci. Nov 1, 2019, 236, 116933. DOI: 10.1016/j.lfs.2019.116933. Epub 2019 Oct 12. PMID: 31614146.
  • Serri, C.; Quagliariello, V.; Iaffaioli, R. V.; Fusco, S.; Botti, G.; Mayol, L.; Biondi, M. Combination Therapy for the Treatment of Pancreatic Cancer Through Hyaluronic Acid-Decorated Nanoparticles Loaded with Quercetin and Gemcitabine: A Preliminary In Vitro Study. J. Cell. Physiol. Apr, 2019, 234(4), 4959–4969. DOI: 10.1002/jcp.27297. Epub 2018 Oct 18. PMID: 30334571.
  • Seyed, M. A.; Ghanadian, M.; Kamarul, T.; Fakurazi, S.; Bagheri, A. The Effect of Quercetin in the Treatment of Cancer: An Overview. Iran. J. Med. Sci. May, 2019, 44(3): 170–177.
  • Shahidi, S.; Rostamizadeh, K.; Fathi, M.; Nedaei, K.; Ramazani, A. Combination of Quercetin Or/And siRna-Loaded DDAB-MPEG-PCL Hybrid Nanoparticles Reverse Resistance to Regorafenib in Colon Cancer Cells. BMC Complement. Med. Ther. 2022 Dec 27, 22(1), 340. DOI: 10.1186/s12906-022-03787-8. PMID: 36575448; PMCID: PMC9793538.
  • Shang, H. S.; Lu, H. F.; Lee, C. H.; Chiang, H. S.; Chu, Y. L.; Chen, A.; Lin, Y. F.; Chung, J. G. Quercetin Induced Cell Apoptosis and Altered Gene Expression in AGS Human Gastric Cancer Cells. Environ. Toxicol. Nov, 2018, 33(11), 1168–1181. DOI: 10.1002/tox.22623. Epub 2018 Aug 27. PMID: 30152185.
  • Sharma, A.; Singh, K.; Almasan, A. Histone H2AX Phosphorylation: A Marker for DNA Damage. Methods Mol. Biol. 2017, 1526, 125–133.
  • Shawky, S.; Makled, S.; Awaad, A.; Boraie, N. Quercetin Loaded Cationic Solid Lipid Nanoparticles in a Mucoadhesive in situ Gel-A Novel Intravesical Therapy Tackling Bladder Cancer. Pharmaceutics. Nov 20, 2022, 14(11), 2527. DOI: 10.3390/pharmaceutics14112527. PMID: 36432718; PMCID: PMC9695231.
  • Shen, X.; Si, Y.; Wang, Z.; Wang, J.; Guo, Y.; Zhang, X. Quercetin Inhibits the Growth of Human Gastric Cancer Stem Cells by Inducing Mitochondrial-Dependent Apoptosis Through the Inhibition of PI3K/Akt Signaling. Int. J. Mol. Med. Aug, 2016, 38(2), 619–626. DOI: 10.3892/ijmm.2016.2625. Epub 2016 Jun 6. PMID: 27278820
  • Shafabakhsh, R.; Asemi, Z. Quercetin: A Natural Compound for Ovarian Cancer Treatment. Journal Of Ovarian Research. Dec, 2019, 12(1), 1–9. DOI: 10.1186/s13048-019-0530-4.
  • Shi, H.; Li, X. Y.; Chen, Y.; Zhang, X.; Wu, Y.; Wang, Z. X.; Chen, P. H.; Dai, H. Q.; Feng, J.; Chatterjee, S., et al. Quercetin Induces Apoptosis via Downregulation of Vascular Endothelial Growth Factor/Akt Signaling Pathway in Acute Myeloid Leukemia Cells. Front Pharmacol. Dec, 2020, 10;11, DOI: 10.3389/fphar.2020.534171. Erratum in: Front Pharmacol. 2021 Feb 08;11:640750. PMID: 33362534; PMCID: PMC7758733, 534171.
  • Shi, X.; Deepak, V.; Wang, L.; Ba, X.; Komori, T.; Zeng, X., et al. Thrombospondin-1 is a Putative Target Gene of Runx2 and Runx3. Int. J. Mol. Sci. 2013, 14(7), 14321–14332. DOI: 10.3390/ijms140714321.
  • Shree, A.; Islam, J.; Sultana, S. Quercetin Ameliorates Reactive Oxygen Species Generation, Inflammation, Mucus Depletion, Goblet Disintegration, and Tumor Multiplicity in Colon Cancer: Probable Role of Adenomatous Polyposis Coli, β-Catenin. Phytother. Res. Apr, 2021, 35(4), 2171–2184. DOI: 10.1002/ptr.6969. Epub 2020 Dec 22. PMID: 33350534.
  • Shu, Y.; Xie, B.; Liang, Z.; Chen, J. Quercetin Reverses the Doxorubicin Resistance of Prostate Cancer Cells by Downregulating the Expression of C-Met. Oncol. Lett. Feb, 2018, 15(2), 2252–2258. DOI: 10.3892/ol.2017.7561. Epub 2017 Dec 8. PMID: 29434932; PMCID: PMC5777119.
  • Singla, R. K.; Sai, C. S.; Chopra, H.; Behzad, S.; Bansal, H.; Goyal, R.; Gautam, R. K.; Tsagkaris, C.; Joon, S.; Singla, S., et al. Natural Products for the Management of Castration-Resistant Prostate Cancer: Special Focus on Nanoparticles Based Studies. Front Cell Dev Biol. Nov 5, 2021, 9, 745177. DOI: 10.3389/fcell.2021.745177.
  • Singh, C. K.; Chhabra, G.; Ndiaye, M. A.; Siddiqui, I. A.; Panackal, J. E.; Mintie, C. A.; Ahmad, N. Quercetin-Resveratrol Combination for Prostate Cancer Management in TRAMP Mice. Cancers (Basel). Aug 2. 2020, 12(8), 2141. DOI: 10.3390/cancers12082141. PMID: 32748838; PMCID: PMC7465013.Sobral, F., Calhelha, R. C., Barros, L., Dueñas, M., Tomás, A., Santos-Buelga, C. Flavonoid Composition and Antitumor Activity of Bee Bread Collected in Northeast Portugal. Molecules. 2017. 22, 22.
  • Son, H. K.; Kim, D. Quercetin Induces Cell Cycle Arrest and Apoptosis in YD10B and YD38 Oral Squamous Cell Carcinoma Cells. Asian Pac. J. Cancer Prev. Jan 1, 2023, 24(1), 283–289. DOI: 10.31557/APJCP.2023.24.1.283. PMID: 36708578
  • Suganthy, N.; Devi, K. P.; Nabavi, S. F.; Braidy, N.; Nabavi, S. M. Bioactive Effects of Quercetin in the Central Nervous System: Focusing on the Mechanisms of Actions. Biomed. Pharmacother. Dec 1, 2016, 84, 892–908. DOI: 10.1016/j.biopha.2016.10.011.
  • Sun, Y.; Xie, W.; Kang, N.; Yi, J.; Ruan, X.; Hu, L.; Zhao, J.; Zheng, X.; Wei, S.; Gao, M. To Explore the Inhibitory Mechanism of Quercetin in Thyroid Papillary Carcinoma Through Network Pharmacology and Experiments. Dis. Markers. Dec 3, 2022, 9541080. DOI: 10.1155/2022/9541080. PMID: 36510497; PMCID: PMC9741536.
  • Taylor, M. A.; Khathayer, F.; Ray, S. K. Quercetin and Sodium Butyrate Synergistically Increase Apoptosis in Rat C6 and Human T98G Glioblastoma Cells Through Inhibition of Autophagy. Neurochem. Res. Jul, 2019, 44(7), 1715–1725. DOI: 10.1007/s11064-019-02802-8. Epub 2019 Apr 22. PMID: 31011879.
  • Teekaraman, D.; Elayapillai, S. P.; Viswanathan, M. P.; Jagadeesan, A. Quercetin Inhibits Human Metastatic Ovarian Cancer Cell Growth and Modulates Components of the Intrinsic Apoptotic Pathway in PA-1 cell Line. Chem. Biol. Interact. Feb 25, 2019, 300, 91–100. DOI: 10.1016/j.cbi.2019.01.008. Epub 2019 Jan 9. PMID: 30639267.
  • Terana, G. T.; Abd-Alhaseeb, M. M.; Omran, G. A.; Okda, T. M. Quercetin Potentiates 5-Fluorouracil Effects in Human Colon Cancer Cells Through Targeting the Wnt/β-Catenin Signalling Pathway: The Role of MiR-27a. Contemp Oncol (Pozn). 2022, 26(3), 229–238. DOI: 10.5114/wo.2022.120361. Epub 2022 Oct 24. PMID: 36381675; PMCID: PMC9641630.
  • Tezerji, S.; Nazari Robati, F.; Abdolazimi, H.; Fallah, A.; Talaei, B. Quercetin’s Effects on Colon Cancer Cells Apoptosis and Proliferation in a Rat Model of Disease. Clin. Nutr. ESPEN. Apr, 2022, 48, 441–445. DOI: 10.1016/j.clnesp.2022.01.004. Epub 2022 Jan 10. PMID: 35331526.
  • Tomas-Hernández, S.; Blanco, J.; Rojas, C.; Roca-Martínez, J.; Ojeda-Montes, M. J.; Beltrán-Debón, R.; Garcia-Vallvé, S.; Pujadas, G.; Arola, L.; Mulero, M. Resveratrol Potently Counteracts Quercetin Starvation-Induced Autophagy and Sensitizes HepG2 Cancer Cells to Apoptosis. Mol. Nutr. Food Res. Mar, 2018, 62(5), 1700610. DOI: 10.1002/mnfr.201700610.
  • Trinh, N. T.; Nguyen, T. M. N.; Yook, J. I.; Ahn, S. G.; Kim, S. A. Quercetin and Quercitrin from Agrimonia Pilosa Ledeb Inhibit the Migration and Invasion of Colon Cancer Cells Through the JNK Signaling Pathway. Pharm (Basel). Mar 17, 2022, 15(3), 364. DOI: 10.3390/ph15030364. PMID: 35337161; PMCID: PMC8951172.
  • Ulusoy, H. G.; Sanlier, N. A Minireview of Quercetin: From Its Metabolism to Possible Mechanisms of Its Biological Activities. Crit. Rev. Food Sci. Nutr. Oct 27, 2020, 60(19), 3290–3303. DOI: 10.1080/10408398.2019.1683810.
  • Vafadar, A.; Shabaninejad, Z.; Movahedpour, A.; Fallahi, F.; Taghavipour, M.; Ghasemi, Y.; Akbari, M.; Shafiee, A.; Hajighadimi, S.; Moradizarmehri, S., et al. Quercetin and Cancer: New Insights into Its Therapeutic Effects on Ovarian Cancer Cells. Cell Biosci. PMID: 32175075; PMCID: PMC7063794. Mar 10 2020, 10, 32. DOI: 10.1186/s13578-020-00397-0.
  • Wang, L.; Ji, S.; Liu, Z.; Zhao, J. Quercetin Inhibits Glioblastoma Growth and Prolongs Survival Rate Through Inhibiting Glycolytic Metabolism. Chemotherapy. 2022, 67(3), 132–141. DOI: 10.1159/000523905. Epub 2022 Mar 4. PMID: 35249013.
  • Wang, Q.; Chen, Y.; Lu, H.; Wang, H.; Feng, H.; Xu, J.; Zhang, B. Quercetin Radiosensitizes Non-Small Cell Lung Cancer Cells Through the Regulation of MiR-16-5p/WEE1 Axis. IUBMB Life. May, 2020, 72(5), 1012–1022. DOI: 10.1002/iub.2242. Epub 2020 Feb 6. PMID: 32027086.
  • Wang, T.; Xiang, Z.; Zhang, X.; Cao, X.; Huang, G. Quercetin Enhances the Efficacy of Chemotherapy in Non-Small-Cell Lung Cancer Cells by Inhibiting Glucose Metabolism. Oncol. Lett. Sep, 2021, 223, 788. DOI: 10.3892/ol.2021.12866. Epub 2021 Jul 9
  • Weng, C. J.; Yen, G. C. Flavonoids, a Ubiquitous Dietary Phenolic Subclass, Exert Extensive In Vitro Anti-Invasive and In Vivo Anti-Metastatic Activities. Cancer And Metastasis Reviews. Jun, 2012, 31(1–2), 323–351. DOI: 10.1007/s10555-012-9347-y.
  • Wu, B.; Zeng, W.; Ouyang, W.; Xu, Q.; Chen, J.; Wang, B.; Zhang, X. Quercetin Induced NUPR1-Dependent Autophagic Cell Death by Disturbing Reactive Oxygen Species Homeostasis in Osteosarcoma Cells. J. Clin. Biochem. Nutr. Sep, 2020, 67(2), 137–145. DOI: 10.3164/jcbn.19-121. Epub 2020 Mar 6. PMID: 33041510; PMCID: PMC7533857.
  • Wu, L.; Li, J.; Liu, T.; Li, S.; Feng, J.; Yu, Q.; Zhang, J.; Chen, J.; Zhou, Y.; Ji, J.et al. Quercetin Shows Anti-Tumor Effect in Hepatocellular Carcinoma LM3 Cells by Abrogating JAK2/STAT3 Signaling Pathway. Cancer Med. Aug, 2019, 810, 4806–4820. DOI: 10.1002/cam4.2388. Epub 2019 Jul 5. PMID: 31273958; PMCID: PMC6712453.
  • Wu, R.; Zhou, T.; Xiong, J.; Zhang, Z.; Tian, S.; Wang, Y.; Chen, J.; Quercetin, T. X. The Ingredient of Xihuang Pills, Inhibits Hepatocellular Carcinoma by Regulating Autophagy and Macrophage Polarization. Front. Biosci. Dec 20, 2022, 27(12), 323. DOI: 10.31083/j.fbl2712323. PMID: 36624942.
  • Wu, T., et al.Pharmacokinetics and Pharmacodynamics of Quercetin in Regulating Tumor Angiogenesis.Eur. J. Pharm. Sci. Aug 30, 2018, 121, 176–185.
  • Xiao, J.; Zhang, B.; Yin, S.; Xie, S.; Huang, K.; Wang, J.; Yang, W.; Liu, H.; Zhang, G.; Liu, X., et al. Quercetin Induces Autophagy-Associated Death in HL-60 Cells Through CaMkkβ/AMPK/mTOR signal Pathway. Acta Biochim Biophys Sin (Shanghai). Sep 25, 2022, 54(9), 1244–1256. DOI: 10.3724/abbs.2022117. PMID: 36148953; PMCID: PMC9827794.
  • Xu, G.; Li, B.; Wang, T.; Wan, J.; Zhang, Y.; Huang, J.; Shen, Y. Enhancing the Anti-Ovarian Cancer Activity of Quercetin Using a Self-Assembling Micelle and Thermosensitive Hydrogel Drug Delivery System. R.S.C. Adv. Jun, 2018, 11;8(38), 21229–21242. DOI: 10.1039/c8ra03274b. Erratum in: RSC Adv 2019 Oct 16;9(57):33193-33194. PMID: 35539921; PMCID: PMC9080896.
  • Xu, W.; Xie, S.; Chen, X.; Pan, S.; Qian, H.; Zhu, X. Effects of Quercetin on the Efficacy of Various Chemotherapeutic Drugs in Cervical Cancer Cells. Drug Des. Devel. Ther. Feb 15, 2021, 15, 577–588. DOI: 10.2147/DDDT.S291865. PMID: 33623367; PMCID: PMC7894806.
  • Xu, Y. X.; Wang, B.; Zhao, X. H. In Vitro Effects and the Related Molecular Mechanism of Galangin and Quercetin on Human Gastric Cancer Cell Line (SGC-7901). Pak. J. Pharm. Sci. Jul 2017, 30(4), 1279–1287. PMID: 29039326
  • Yamada, N.; Matsushima-Nishiwaki, R.; Kozawa, O. Quercetin Suppresses the Migration of Hepatocellular Carcinoma Cells Stimulated by Hepatocyte Growth Factor or Transforming Growth Factor-α: Attenuation of AKT Signaling Pathway. Arch. Biochem. Biophys Mar 30. 2020, 682, 108296. DOI: 10.1016/j.abb.2020.108296. Epub 2020 Feb 4. PMID: 32032576.
  • Yang, F.; Jiang, X.; Song, L.; Wang, H.; Mei, Z.; Xu, Z.; Xing, N. Quercetin Inhibits Angiogenesis Through Thrombospondin-1 Upregulation to Antagonize Human Prostate Cancer PC-3 Cell Growth In Vitro and In Vivo. Oncol. Rep. 2016, 35(3), 1602–1610. DOI: 10.3892/or.2015.4481.
  • Yang, L.; Hu, Z.; Zhu, J.; Liang, Q.; Zhou, H.; Li, J.; Fan, X.; Zhao, Z.; Pan, H.; Fei, B. Systematic Elucidation of the Mechanism of Quercetin Against Gastric Cancer via Network Pharmacology Approach. Biomed Res. Int. 2020 Sep 3, PMID: 32964029; PMCID: PMC7486643. 2020, 1–11. DOI: 10.1155/2020/3860213.
  • Yang, P.; Li, X.; Wen, Q.; Zhao, X. Quercetin Attenuates the Proliferation of Arsenic-Related Lung Cancer Cells via a Caspase-Dependent DNA Damage Signaling. Mol. Carcinog. Jul, 2022, 61(7), 655–663. DOI: 10.1002/mc.23408. Epub 2022 Apr 18. PMID: 35436022
  • Zeng, Y.; Shen, Z.; Gu, W.; Wu, M. Bioinformatics Analysis to Identify Action Targets in NCI-N87 Gastric Cancer Cells Exposed to Quercetin. Pharm. Biol. 2018, 56(1), 393–398. DOI: 10.1080/13880209.2018.1493610.
  • Zhang, C.; Hao, Y.; Sun, Y.; Liu, P. Quercetin Suppresses the Tumorigenesis of Oral Squamous Cell Carcinoma by Regulating microRNA-22/WNT1/β-Catenin Axis. J. Pharmacol. Sci. Jun, 2019, 140(2), 128–136. DOI: 10.1016/j.jphs.2019.03.005. Epub 2019 May 4. PMID: 31257059.
  • Zhang, L.; Cheng, X.; Gao, Y., et al. Quercetin: A Promising Antioxidant for Cancer Prevention and Treatment. Biomed. Pharmacother. Mar, 2020, 121, 109604. DOI: 10.1016/j.biopha.2019.109604.
  • Zhang, X.; Huang, J.; Yu, C.; Xiang, L.; Li, L.; Shi, D.; Lin, F. Quercetin Enhanced Paclitaxel Therapeutic Effects Towards PC-3 Prostate Cancer Through ER Stress Induction and ROS Production. Onco. Targets Ther. Jan 16, 2020, 13, 513–523. DOI: 10.2147/OTT.S228453. PMID: 32021294; PMCID: PMC6970612.
  • Zhao, J.; Fang, Z.; Zha, Z.; Sun, Q.; Wang, H.; Sun, M.; Qiao, B. Quercetin Inhibits Cell Viability, Migration and Invasion by Regulating MiR-16/HOXA10 Axis in Oral Cancer. Eur. J. Pharmacol. Mar 15, 2019, 847, 11–18. DOI: 10.1016/j.ejphar.2019.01.006. Epub 2019 Jan 9. PMID: 30639311.
  • Zhaorigetu, F. I.; Belal, A.; Badawi, M. H. A.; Abdelhady, A. A.; Galala, F. M. A. A.; El-Sharkawy, A.; El-Dahshan, A. A.; Mehany, A. B. M.; Mehany, A. B. M. Antiproliferative, Apoptotic Effects and Suppression of Oxidative Stress of Quercetin Against Induced Toxicity in Lung Cancer Cells of Rats: In Vitro and In Vivo Study. J. Cancer Jun, 26, 2021, 1217, 5249–5259. DOI: 10.7150/jca.52088. PMID: 34335941; PMCID: PMC8317526.
  • Zhu, Q.; Yang, L.; Yang, H.; Han, Y.; Chen, Y.; He, Y. Quercetin Alleviates the Progression of Breast Cancer-Related Depression via Inhibiting the Pyroptosis and Promoting the Immune Response. Mediators Inflamm. Mar, 3, 2022, 8011988. DOI: 10.1155/2022/8011988. PMID: 35369029; PMCID: PMC8966747.
  • Zhu, S.; Yu, W.; Bi, L.; Qin, F.; Li, J.; Zeng, H.; Lu, L. Quercetin Induces Apoptosis of Human Breast Cancer Cells by Activating PTEN and Inhibiting PI3K/AKT and JNK Signaling Pathways. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. Aug 2022, 38(8), 714–720. Chinese. PMID: 35851085.
  • Zulkefli, N.; Che Zahari, C. N.; Sayuti, N. H.; Kamarudin, A. A.; Saad, N.; Hamezah, H. S.; Bunawan, H.; Baharum, S. N.; Mediani, A.; Ahmed, Q. U., et al. Flavonoids as Potential Wound-Healing Molecules: Emphasis on Pathways Perspective. Int. J. Mol. Sci. Feb 27, 2023, 24 5, 4607. DOI: 10.3390/ijms24054607.

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