Impact of extraction techniques and process optimization on antioxidant and antibacterial potential of Kalanchoe pinnata leaf extract

References

• Mesímesías, F. J.; Martín, A.; Hernández, A. Consumers’ Growing Appetite for Natural Foods: Perceptions Towards the Use of Natural Preservatives in Fresh Fruit. Food Res. Int. 2021, 150, 110749. DOI: 10.1016/j.foodres.2021.110749.
   PubMed Web of Science ®Google Scholar
• Generalić Mekinić, I.; Skroza, D.; Ljubenkov, I.; Katalinić, V.; Šimat, V. Antioxidant and Antimicrobial Potential of Phenolic Metabolites from Traditionally Used Mediterranean Herbs and Spices. Foods. 2019, 8(11), 579. DOI: 10.3390/foods8110579.
   PubMed Web of Science ®Google Scholar
• Assis de Andrade, E.; Machinski, I.; Terso Ventura, A. C.; Barr, S. A.; Pereira, A. V.; Beltrame, F. L.; Strangman, W. K.; Williamson, R. T. A Review of the Popular Uses, Anatomical, Chemical, and Biological Aspects of Kalanchoe (Crassulaceae): A Genus of Plants Known As “Miracle Leaf”. Molecules 2023, 28(14), 5574. DOI: 10.3390/molecules28145574.
   PubMed Web of Science ®Google Scholar
• Agüero-Hernández, A. L.; Rosales-López, C.; Herrera, C.; Vargas-Picado, A.; Muñoz, R.; Abdelnour-Esquivel, A. Hypoglycemic Effect of Kalanchoe Pinnata (Lam) Pers. Leaf Extract. Pharmacogn. J. 2020, 12(3), 557–561. DOI: 10.5530/pj.2020.12.84.
   Google Scholar
• Vandebroek, I.; Picking, D. Bryophyllum Pinnatum (Lam.) Oken (Crassulaceae). In Popular Medicinal Plants in Portland and Kingston, Jamaica; Vandebroek, I.; Picking, D.; Eds.; Springer: Cham, 2020; pp. 61–70.
   Google Scholar
• Rahman, R.; Al-Sabahi, J. N.; Ghaffar, A.; Nadeem, F.; Umar, A. Phytochemical, Morphological, Botanical, and Pharmacological Aspects of a Medicinal Plant: Kalanchoe Pinnata–A Review Article. Int. J. Chem. And Biochemical Sci. 2019, 16, 5–10.
   Google Scholar
• Salehi, B.; Machin, L.; Monzote, L.; Sharifi-Rad, J.; Ezzat, S. M.; Salem, M. A.; Cho, W. C.; El Mahdy, N. M.; Kılıç, C. S.; Sytar, O. Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health. ACS. Omega 2020, 5(20), 11849–11872. DOI: 10.1021/acsomega.0c01818.
   PubMed Web of Science ®Google Scholar
• Stefanowicz-Hajduk, J.; Hering, A.; Gucwa, M.; Hałasa, R.; Soluch, A.; Kowalczyk, M.; Stochmal, A.; Ochocka, R. Biological Activities of Leaf Extracts from Selected Kalanchoe Species and Their Relationship with Bufadienolides Content. Pharm. Biol. 2020, 58(1), 732–740. DOI: 10.1080/13880209.2020.1795208.
   PubMed Web of Science ®Google Scholar
• Dighade, R.; Ingole, R.; Ingle, P.; Gade, A.; Hajare, S.; Ingawale, M. Nephroprotective Effect of Bryophyllum Pinnatum‐Mediated Silver Nanoparticles in Ethylene Glycol‐Induced Urolithiasis in Rat. IET Nanobiotechnol. 2021, 15(3), 266–276. DOI: 10.1049/nbt2.12011.
   PubMed Web of Science ®Google Scholar
• Alishan Zia, D. C.; Kumar, P. S.; Maurya, V. K.; Selvakumar, P.; Verma, V. S. COMPERATIVE STUDY on HERBAL ANTIOXIDANT PRESENT in Bryophyllum Pinnatum PARTS (LEAVES, STEM and ROOTS). YMER Digit. 2022, 21(4), 319–331. DOI: 10.37896/YMER21.04/29.
   Google Scholar
• Adibe, M. K.; Gabriel, I. M.; Akintunde, A. A. M.; Esther, A. O. Chemical Compositions and Antioxidant Activity of Leaf and Stem Essential Oils of Bryophyllum Pinnatum (Lam.) Kurz. GSC Biol. And Pharm. Sci. 2019, 9(2), 057–064. DOI: 10.30574/gscbps.2019.9.2.0184.
   Google Scholar
• Latif, A.; Ashiq, K.; Qayyum, M.; Ashiq, S.; Ali, E.; Anwer, I. PHYTOCHEMICAL and PHARMACOLOGICAL PROFILE of the MEDICINAL HERB: BRYOPHYLLUM PINNATUM. JAPS: J. Anim. & Plant. Sci. 2019, 29(6), 1528–1534.
   Web of Science ®Google Scholar
• Asfaw, T. B.; Esho, T. B.; Bachheti, A.; Bachheti, R. K.; Pandey, D. P.; Husen, A. Exploring Important Herbs, Shrubs, and Trees for Their Traditional Knowledge, Chemical Derivatives, and Potential Benefits. In Herbs, Shrubs, and Trees of Potential Medicinal Benefits; Husen, A.; Ed.; Boca Raton: CRC Press, 2022; pp. 1–26.
   Google Scholar
• Silva Ferreira, R. G. D.; Souza Fernandes, N. D.; Veiga-Junior, V. F. D. Kalanchoe Brasiliensis Camb. and Kalanchoe Pinnata (Lamk.) Pers. In Medicinal and Aromatic Plants of South America; Albuquerque, UP.; Patil, U.; Máthé, Á.; Eds.; Springer: Dordrecht, 2018; pp. 265–273.
   Google Scholar
• Christiana, K. A.; Mary, K. L.; Esther, A. A. PHYTOCHEMICAL, ANTIOXIDANT and ANTIMICROBIAL EVALUATION of NIGERIAN KALANCHOE PINNATA (LAM.). J. Chem. Soc. Of Nigeria 2019, 44(6), 1080–1085.
   Google Scholar
• Fongnzossie Fedoung, E.; Biwole, A. B.; Nyangono Biyegue, C. F.; Ngansop Tounkam, M.; Akono Ntonga, P.; Nguiamba, V. P.; Ngogang Yonkeu, J.; Forbi Funwi, P.; Tonga, C.; Nguenang, G. M. A Review of Cameroonian Medicinal Plants with Potentials for the Management of the COVID-19 Pandemic. Adv. Tradit. Med. 2021, 23(1), 1–26. DOI: 10.1007/s13596-021-00567-6.
   Google Scholar
• Elufioye, T. O.; Oyedeji, A. O.; Habtemariam, S. A Review of the Traditional Uses, Phytochemistry and Pharmacology of Bryophyllum Pinnatum (Lam.)(crassulaceae). J. Biologically Act. Products From Nat. 2022, 12(3), 190–222. DOI: 10.1080/22311866.2021.1988706.
   Google Scholar
• Mejía-Méndez, J. L.; Bach, H.; Lorenzo-Leal, A. C.; Navarro-López, D. E.; López-Mena, E. R.; Hernández, L. R.; Sánchez-Arreola, E. Biological Activities and Chemical Profiles of Kalanchoe Fedtschenkoi Extracts. Plants 2023, 12(10), 1943. DOI: 10.3390/plants12101943.
   Google Scholar
• Jha, A. K.; Sit, N. Extraction of Bioactive Compounds from Plant Materials Using Combination of Various Novel Methods: A Review. Trends Food Sci. Technol. 2022, 119, 579–591. DOI: 10.1016/j.tifs.2021.11.019.
   Web of Science ®Google Scholar
• AOAC. International Guidelines for Laboratories Performing Microbiological and Chemical Analyses of Food and Pharmaceuticals: An Aid to Interpretation of ISO/IEC 17025: 2005 AOAC International; Rockville, MD: AOAC International, 2006.
   Google Scholar
• Mohammed, M. I.; Ahmad, U. M. Mineral Elements Content of Some Coarse Grains Used As Staple Food in Kano Metropolis, Nigeria. Bayero J. Pure App. Sci. 2014, 7(1), 85–89. DOI: 10.4314/bajopas.v7i1.16.
   Google Scholar
• Truong, D. H.; Nguyen, D. H.; Ta, N. T. A.; Bui, A. V.; Do, T. H.; Nguyen, H. C. Evaluation of the Use of Different Solvents for Phytochemical Constituents, Antioxidants, and in vitro Anti-Inflammatory Activities of Severinia Buxifolia. J. Food Qual. 2019, 2019, 1–9. DOI: 10.1155/2019/8178294.
   Web of Science ®Google Scholar
• Lim, S.; Lee, K. T. Investigation of Impurity Tolerance and Thermal Stability for Biodiesel Production from Jatropha Curcas L. Seeds Using Supercritical Reactive Extraction. Energy. 2014, 68, 71–79. DOI: 10.1016/j.energy.2014.02.056.
   Web of Science ®Google Scholar
• Ghasemzadeh, A.; Jaafar, H. Z.; Rahmat, A.; Swamy, M. K. Optimization of Microwave-Assisted Extraction of Zerumbone from Zingiber Zerumbet L. Rhizome and Evaluation of Antiproliferative Activity of Optimized Extracts. Chem. Cent. J. 2017, 11(1), 1–10. DOI: 10.1186/s13065-016-0235-3.
   PubMedGoogle Scholar
• Sengul, M.; Yildiz, H.; Gungor, N.; Cetin, B.; Eser, Z.; Ercisli, S. Total Phenolic Content, Antioxidant and Antimicrobial Activities of Some Medicinal Plants. Pak. J. Pharm. Sci. 2009, 22(1), 102–106.
   PubMed Web of Science ®Google Scholar
• Ghasemzadeh, A.; Jaafar, H. Z. Profiling of Phenolic Compounds and Their Antioxidant and Anticancer Activities in Pandan (Pandanus Amaryllifolius) Extracts from Different Locations of Malaysia. BMC Complem. Altern. Med 2013, 13(1), 341. DOI: 10.1186/1472-6882-13-341.
   PubMedGoogle Scholar
• Cheel, J.; Theoduloz, C.; Rodríguez, J. A.; Caligari, P. D.; Schmeda-Hirschmann, G. Free Radical Scavenging Activity and Phenolic Content in Achenes and Thalamus from Fragaria Chiloensis Ssp. Chiloensis, F. Vesca and F. X Ananassa Cv. Chandler. Food Chem. 2007, 102(1), 36–44. DOI: 10.1016/j.foodchem.2006.04.036.
   Web of Science ®Google Scholar
• Rawson, A.; Hossain, M. B.; Patras, A.; Tuohy, M.; Brunton, N. Effect of Boiling and Roasting on the Polyacetylene and Polyphenol Content of Fennel (Foeniculum vulgare) Bulb. Food Res. Int. 2013, 50(2), 513–518. DOI: 10.1016/j.foodres.2011.01.009.
   Web of Science ®Google Scholar
• Jayaprakasha, G. K.; Singh, R. P.; Sakariah, K. K. Antioxidant Activity of Grape Seed (Vitis Vinifera) Extracts on Peroxidation Models in vitro. Food Chem. 2001, 73(3), 285–290. DOI: 10.1016/S0308-8146(00)00298-3.
   Web of Science ®Google Scholar
• Ettahiri, W.; Salim, R.; Adardour, M.; Ech-Chihbi, E.; Yunusa, I.; Alanazi, M. M.; Taleb, M.; Barnossi, A. E.; Merzouki, O.; Iraqi Housseini, A.; Rais, Z. Synthesis, Characterization, Antibacterial, Antifungal and Anticorrosion Activities of 1, 2, 4-Triazolo [1, 5-A] Quinazolinone. Molecules 2023, 28(14), 5340. DOI: 10.3390/molecules28145340.
   PubMed Web of Science ®Google Scholar
• Niculae, M. I. H. A. E. L. A.; Spînu, M. A. R. I. N. A.; Şandru, C. D.; Brudaşcă, F.; Cadar, D.; Szakacs, B. I. A. N. C. A.; Mateş, C. I. Antimicrobial Potential of Some Lamiaceae Essential Oils Against Animal Multiresistant Bacteria. Lucrări Ştinłifice Medicină Veterinară. 2009, 42(1), 170–175.
   Google Scholar
• Pawar, R.; Bhutani, K. Effect of Oleanane Triterpenoids from Terminalia Arjuna—A Cardioprotective Drug on the Process of Respiratory Oxyburst. Phytomed 2005, 12(5), 391–393. DOI: 10.1016/j.phymed.2003.11.007.
   PubMed Web of Science ®Google Scholar
• Comuzzi, L.; Tumedei, M.; Pontes, A. E.; Piattelli, A.; Iezzi, G. Primary Stability of Dental Implants in Low-Density (10 and 20 Pcf) Polyurethane Foam Blocks: Conical Vs Cylindrical Implants. Int. J. Environ. Res. And Public Health 2020, 17(8), 2617. DOI: 10.3390/ijerph17082617.
   PubMed Web of Science ®Google Scholar
• Nishino, S.; Fujiki, Y.; Sato, T.; Kato, Y.; Shirai, R.; Oizumi, H.; Yamauchi, J.; Ohbuchi, K.; Miyamoto, Y.; Mizoguchi, K. Hesperetin, a citrus flavonoid, ameliorates inflammatory cytokine-mediated inhibition of oligodendroglial cell morphological differentiation. Neurol. Int. 2022, 14(2), 471–487. DOI: 10.3390/neurolint14020039.
   PubMed Web of Science ®Google Scholar
• Sokolova, I. M.; Frederich, M.; Bagwe, R.; Lannig, G.; Sukhotin, A. A. Energy Homeostasis As an Integrative Tool for Assessing Limits of Environmental Stress Tolerance in Aquatic Invertebrates. Mar. Environ. Res. 2012, 79, 1–15. DOI: 10.1016/j.marenvres.2012.04.003.
   PubMed Web of Science ®Google Scholar
• Iorember, F. M. Malnutrition in Chronic Kidney Disease. Front. Pediatr. 2018, 6, 161. DOI: 10.3389/fped.2018.00161.
   PubMed Web of Science ®Google Scholar
• Safder, I.; Khan, S.; Islam, I. U.; Ali, M. K.; Bibi, Z.; Waqas, M. Pichia Pastoris Expression System: A Potential Candidate to Express Protein in Industrial and Biopharmaceutical Domains. Biomed. Lett. 2018, 4(1), 1–14.
   Google Scholar
• Gill, S. K.; Rossi, M.; Bajka, B.; Whelan, K. Dietary Fibre in Gastrointestinal Health and Disease. Nat. Rev. Gastroenterol. Hepatol. 2021, 18(2), 101–116. DOI: 10.1038/s41575-020-00375-4.
   PubMed Web of Science ®Google Scholar
• Sueyoshi, M.; Fukunaga, M.; Mei, M.; Nakajima, A.; Tanaka, G.; Murase, T.; Narita, Y.; Hirata, S.; Kadowaki, D. Effects of Lactulose on Renal Function and Gut Microbiota in Adenine-Induced Chronic Kidney Disease Rats. Clin. Exp. Nephrol. 2019, 23(7), 908–919. DOI: 10.1007/s10157-019-01727-4.
   PubMed Web of Science ®Google Scholar
• Properzi, C.; O’Sullivan, T. A.; Sherriff, J. L.; Ching, H. L.; Jeffrey, G. P.; Buckley, R. F.; Adams, L. A.; MacQuillan, G. C.; Garas, G.; Adams, L. A. Ad Libitum Mediterranean and Low‐Fat Diets Both Significantly Reduce Hepatic Steatosis: A Randomized Controlled Trial. Hepatology 2018, 68(5), 1741–1754. DOI: 10.1002/hep.30076.
   PubMed Web of Science ®Google Scholar
• Dave, S. C.; Fisher, M. Relative Energy Deficiency in Sport (RED–S). Curr. Probl. In Pediatr. And Adolesc. Health Care. 2022, 52(8), 101242. DOI: 10.1016/j.cppeds.2022.101242.
   PubMed Web of Science ®Google Scholar
• Shukla, G.; Subrahmanyam, C.; Yamuna, M.; Kumar, C. S. CC MATE Tablets: A Well-Balanced Calcium Supplement for Well-Functioning of Intestinal Ecosystem & for Healthy Body. Mediterranean J. Basic And Appl. Sci. (MJBAS) 2021, 5(4), 120–127. DOI: 10.46382/MJBAS.2021.5407.
   Google Scholar
• Farias, P. M.; Marcelino, G.; Santana, L. F.; de Almeida, E. B.; Guimarães, R. D. C. A.; Pott, A.; Freitas, K. D. C.; Freitas, K. D. C. Minerals in Pregnancy and Their Impact on Child Growth and Development. Molecules 2020, 25(23), 5630. DOI: 10.3390/molecules25235630.
   PubMed Web of Science ®Google Scholar
• Shemishere, U. B.; Taiwo, J. E.; Erhunse, N.; Omoregie, E. S. Comparative Study on the Proximate Analysis and Nutritional Composition of Musanga Cercropioides and Maesobotyra Barteri Leaves. J. Appl. Sci. Environ. Manage. 2018, 22(2), 287–291. DOI: 10.4314/jasem.v22i2.22.
   Google Scholar
• Launonen, H.; Pang, Z.; Linden, J.; Siltari, A.; Korpela, R.; Vapaatalo, H. Evidence for Local Aldosterone Synthesis in the Large Intestine of the Mouse. J. Physiol. And Pharmacol. 2021, 72(5), 807–815.
   Web of Science ®Google Scholar
• Baj, J.; Flieger, W.; Teresiński, G.; Buszewicz, G.; Sitarz, R.; Forma, A.; Karakuła, K.; Maciejewski, R. Magnesium, Calcium, Potassium, Sodium, Phosphorus, Selenium, Zinc, and Chromium Levels in Alcohol Use Disorder: A Review. J. Clin. Med. 2020, 9(6), 1901. DOI: 10.3390/jcm9061901.
   PubMed Web of Science ®Google Scholar
• Mahamuni-Badiger, P. P.; Patil, P. M.; Badiger, M. V.; Patel, P. R.; Thorat-Gadgil, B. S.; Pandit, A.; Bohara, R. A. Biofilm Formation to Inhibition: Role of Zinc Oxide-Based Nanoparticles. Mater. Sci. Eng. C. 2020, 108, 110319. DOI: 10.1016/j.msec.2019.110319.
   PubMed Web of Science ®Google Scholar
• Godswill, A. G.; Somtochukwu, I. V.; Ikechukwu, A. O.; Kate, E. C. Health Benefits of Micronutrients (Vitamins and Minerals) and Their Associated Deficiency Diseases: A Systematic Review. Int. J. Food Sci. 2020, 3(1), 1–32. DOI: 10.47604/ijf.1024.
   Google Scholar
• Germano, C.; Messina, A.; Tavella, E.; Vitale, R.; Avellis, V.; Barboni, M.; Masturzo, B.; Revelli, A.; Zola, P.; Manzoni, P. Fetal Brain Damage During Maternal COVID-19: Emerging Hypothesis, Mechanism, and Possible Mitigation Through Maternal-Targeted Nutritional Supplementation. Nutrients 2022, 14(16), 3303. DOI: 10.3390/nu14163303.
   PubMed Web of Science ®Google Scholar
• Prasad Pandey, B.; Prakash Pradhan, S.; Adhikari, K. LC‐ESI‐QTOF‐MS for the Profiling of the Metabolites and in vitro Enzymes Inhibition Activity of Bryophyllum Pinnatum and Oxalis Corniculata Collected from Ramechhap District of Nepal. Chem. & Biodivers. 2020, 17(6), e2000155. DOI: 10.1002/cbdv.202000155.
   PubMed Web of Science ®Google Scholar
• Portal, T.; Tavares, M.; Ataide, M.; Barbosa, N. R.; da Silva, J. R.; Moraes, W. P.; Vieira, J. L. Photoprotective Activity of Plants Used for Skin Disorders by the Native Population from the Brazilian Amazon Basin: A Preliminary Study. Pharmacogn. Res. 2023, 15(1), 112–118. DOI: 10.5530/097484900267.
   Web of Science ®Google Scholar
• Mejía-Méndez, J. L.; Navarro-López, D. E.; Sanchez-Martinez, A.; Ceballos-Sanchez, O.; Garcia-Amezquita, L. E.; Tiwari, N.; Juarez-Moreno, K.; Sanchez-Ante, G.; López-Mena, E. R. Lanthanide-Doped ZnO Nanoparticles: Unraveling Their Role in Cytotoxicity, Antioxidant Capacity, and Nanotoxicology. Antioxidants 2024, 13(2), 213. DOI: 10.3390/antiox13020213.
   Web of Science ®Google Scholar
• Hamilton-Amachree, A.; Uzoekwe, N. M. Phytochemical Analysis and Assessment of the Antibacterial and Antioxidant Activities of the Aqueous and Ethanolic Leaf Extracts of Life Plant (Kalanchoe Pinnata L.) in the Niger Delta Nigeria. Fac. Of Nat. And Appl. Sci. J. Sci. Innovations 2022, 3(3), 1–10.
   Google Scholar
• Thaksala, H. K. S.; Hettiarachchi, C. O.; Gunathilake, K. D. P. P. Evaluation of Functional Properties in Ready-To-Drink Beverage Formulated with Kalanchoe Pinnata (Akkapana) and Aloe Vera. J. Food And Bioprocess Eng. 2022, 5(2), 168–177.
   Google Scholar
• Ojo, O. A.; Ojo, A. B.; Ajiboye, B. O.; Olaiya, O.; Akawa, A.; Olaoye, O.; Oyinloye, B. E.; Idowu, O.; Olasehinde, O.; Obafemi, T. Inhibitory Effect of Bryophyllum Pinnatum (Lam.) Oken Leaf Extract and Their Fractions on α-Amylase, α-Glucosidase and Cholinesterase Enzyme. Pharmacogn. J. 2018, 10(3), 497–506. DOI: 10.5530/pj.2018.3.82.
   Google Scholar
• Ivanova, A.; Gerasimova, E.; Gazizullina, E. Study of Antioxidant Properties of Agents from the Perspective of Their Action Mechanisms. Molecules. 2020, 25(18), 4251. DOI: 10.3390/molecules25184251.
   PubMed Web of Science ®Google Scholar
• Daniel, I. E.; Akpan, E. I.; Utam, E. C. Phytochemical Evaluation, Antioxidant and Antimicrobial Activities of Various Extracts from Leaves and Stems of Bryophyllum Pinnatum. Nepal J. Biotechnol. 2020, 8(1), 17–28. DOI: 10.3126/njb.v8i1.30206.
   Google Scholar
• Scheller, D.; Becker, F.; Wimbert, A.; Meggers, D.; Pienkoß, S.; Twittenhoff, C.; Knoke, L. R.; Leichert, L. I.; Narberhaus, F. The Oxidative Stress Response, in Particular the KatY Gene, Is Temperature-Regulated in Yersinia Pseudotuberculosis. PLOS Genet. 2023, 19(7), e1010669. DOI: 10.1371/journal.pgen.1010669.
   PubMed Web of Science ®Google Scholar
• Kosmidou, M.; Klouras, E.; Rapti, I.; Filippas-Ntekouan, S.; Milionis, H.; Komatsu, H. Acute Brucellosis and Cirrhosis: The Triggering Event of Fatal Liver Decompensation. Case Rep. Hepatol. 1, 2020, 2020, 1–4. DOI: 10.1155/2020/8868001.
   Google Scholar
• Abbas, R.; Chakkour, M.; Zein El Dine, H.; Folorunsho Obaseki, E.; Obeid, S. T.; Jezzini, A.; Ghssein, G.; Ezzeddine, Z. General Overview of Klebsiella Pneumonia: Epidemiology and the Role of Siderophores in Its Pathogenicity. Biology 2024, 13(2), 78.
   PubMedGoogle Scholar
• Mueller, M.; Tainter, C. R. Escherichia coli Infection. In StatPearls [Internet]; Tainter, CR.; Ed.; Treasure Island (FL): StatPearls Publishing, 2023.
   Google Scholar
• Hammadi, K. M. Evaluation of Liver and Renal Function Tests Together with Histopathological Alterations in Rabbits Infected with a Virulent Strain of Proteus vulgaris. Biomedicine. 2023, 43(5), 1613–1620. DOI: 10.51248/.v43i5.3571.
   Google Scholar
• Parham, S.; Kharazi, A. Z.; Bakhsheshi-Rad, H. R.; Nur, H.; Ismail, A. F.; Sharif, S.; RamaKrishna, S.; Berto, F. Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials. Antioxidants. 2020, 9(12), 1309. DOI: 10.3390/antiox9121309.
   Web of Science ®Google Scholar
• Santos, P. H.; Kammers, J. C.; Silva, A. P.; Oliveira, J. V.; Hense, H. Antioxidant and Antibacterial Compounds from Feijoa Leaf Extracts Obtained by Pressurized Liquid Extraction and Supercritical Fluid Extraction. Food Chem. 2021, 344, 128620. DOI: 10.1016/j.foodchem.2020.128620.
   PubMed Web of Science ®Google Scholar
• Bouarab Chibane, L.; Degraeve, P.; Ferhout, H.; Bouajila, J.; Oulahal, N. Plant Antimicrobial Polyphenols as Potential Natural Food Preservatives. J. Sci. Food Agric. 2019, 99(4), 1457–1474. DOI: 10.1002/jsfa.9357.
   PubMed Web of Science ®Google Scholar
• Brovarets’, O. H. O.; Hovorun, D. M.; Salahub, D. Intramolecular Tautomerization of the Quercetin Molecule Due to the Proton Transfer: QM Computational Study. PLOS One. 2019, 14(11), e0224762. DOI: 10.1371/journal.pone.0224762.
   PubMed Web of Science ®Google Scholar
• Nalini, T.; Khaleel Basha, S.; Mohamed Sadiq, A.; Sugantha Kumari, V. Fabrication and Evaluation of Nanoencapsulated Quercetin for Wound Healing Application. Polym. Bull. 2023, 80(1), 515–540. DOI: 10.1007/s00289-022-04094-5.
   Web of Science ®Google Scholar
• Liu, X.; Song, L. Quercetin Protects Human Liver Cells from O, p’-DDT-Induced Toxicity by Suppressing Nrf2 and NADPH Oxidase-Regulated ROS Production. Food Chem. Toxicol. 2022, 161, 112849. DOI: 10.1016/j.fct.2022.112849.
   PubMed Web of Science ®Google Scholar
• Araújo, E. R. D. Kalanchoe brasilienses Cambess e Kalanchoe pinnata (Lamarck) Persoon: caracterização química, avaliação gastroprotetora e antiinflamatória tópica. Dissertação de mestrado em Ciências Farmacêuticas. Natal: Universidade Federal do Rio Grande do Norte, 2017.
   Google Scholar
• Coutinho, M. A. S.; Casanova, L. M.; Nascimento, L. B. D. S.; Leal, D.; Palmero, C.; Toma, H. K.; Costa, S. S.; Nasciutti, L. E.; Costa, S. S. Wound Healing Cream Formulated with Kalanchoe Pinnata Major Flavonoid Is As Effective As the Aqueous Leaf Extract Cream in a Rat Model of Excisional Wound. Nat. Prod. Res. 2021, 35(24), 6034–6039. DOI: 10.1080/14786419.2020.1817012.
   PubMed Web of Science ®Google Scholar
• Araújo, E. R. D.; Guerra, G. C. B.; Araújo, D. F.; de, S.; De Araújo, A. A.; Fernandes, J. M.; Júnior, R. F.; De, A.; Da Silva, V. C.; De Carvalho, T. G., et al. Gastroprotective and Antioxidant Activity of Kalanchoe Brasiliensis and Kalanchoe Pinnata Leaf Juices Against Indomethacin and Ethanol- Induced Gastric Lesions in Rats. Int. J. Mol. Sci. 2018, 19(5), 1265. DOI: 10.3390/ijms19051265.
   PubMed Web of Science ®Google Scholar
• Chen, J.; Li, G.; Sun, C.; Peng, F.; Yu, L.; Chen, Y.; Peng, C.; Cao, X.; Tang, Y.; Xie, X. Chemistry, Pharmacokinetics, Pharmacological Activities, and Toxicity of Quercitrin. Phytotherapy Res. 2022, 36(4), 1545–1575. DOI: 10.1002/ptr.7397.
   PubMed Web of Science ®Google Scholar
• Chibli, L. A. Caracterização química e atividades biológicas de Bryophyllum pinnatum (Lam.) Oken. tópica. Dissertação de mestrado em Ciências Farmacêuticas. Brasil: Universidade Federal do Rio Grande do Norte, 2013.
   Google Scholar
• Sobreira, F.; Hernandes, L. S.; Vetore-Neto, A.; Díaz, I. E.; Santana, F. C.; Mancini-Filho, J.; Bacchi, E. M. Gastroprotective Activity of the Hydroethanolic Extract and Ethyl Acetate Fraction from Kalanchoe Pinnata (Lam.) Pers. Braz. J. Pharm. Sci. 2017, 53(1). DOI: 10.1590/s2175-97902017000116027.
   Web of Science ®Google Scholar