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Technical Papers

Particulate matter components, sources, and health: Systematic approaches to testing effects

, , , &
Pages 544-558 | Received 30 Sep 2014, Accepted 15 Dec 2014, Published online: 14 Apr 2015

References

  • Austin, E., B. Coull, D. Thomas, and P. Koutrakis. 2012. A framework for identifying distinct multipollutant profiles in air pollution data. Environ. Int. 45:112–121. doi:10.1016/j.envint.2012.04.003
  • Balachandran, S., J.E. Pachon, Y. Hu, D. Lee, J.A. Mulholland, and A.G. Russell. 2012. Ensemble-trained source apportionment of fine particulate matter and method uncertainty analysis. Atmos. Environ. 61:387–394. doi:10.1016/j.atmosenv.2012.07.031
  • Barzyk, T.M., A. Ciesielski, R.C. Shores, E.D. Thoma, R.L. Seila, V. Isakov, and R.W. Baldauf. 2012. Near-road multipollutant profiles: Associations between volatile organic compounds and a tracer gas surrogate near a busy highway. J. Air Waste Manage. Assoc. 62:594–603. doi:10.1080/10473289.2012.656819
  • Bell, M.L. 2012. Assessment of the Health Impacts of Particulate Matter Characteristics, 5–38. Research Report 161. Boston, MA: Health Effects Institute.
  • Bellavia, A., B. Urch, M. Speck, R.D. Brook, J.A. Scott, B. Albetti, B. Behbod, M. North, L. Valeri, P.A. Bertazzi, F. Silverman, D. Gold, and A.A. Baccarelli. 2013. DNA hypomethylation, ambient particulate matter, and increased blood pressure: Findings from controlled human exposure experiments. J. Am. Heart Assoc. 2:e000212. doi:10.1161/JAHA.113.000212
  • Brook, R.D., R.L Bard, M. Morishita, J.T. Dvonch, L. Wang, H.Y. Yang, C. Spino, B. Mukherjee, M.J. Kaplan, S. Yalavarthi, E.A. Oral, N. Ajluni, Q. Sun, J.R. Brook, J. Harkema, and S. Rajagopalan. 2014. Hemodynamic, autonomic, and vascular effects of exposure to coarse particulate matter air pollution from a rural location. Environ. Health Perspect. 122:624–630. doi:10.1289/ehp.1306595
  • Brook, R.D., S. Rajagopalan, C.A. Pope III, J.R. Brook, A. Bhatnagar, A.V. Diez-Roux, F. Holguin, Y. Hong, R.V. Luepker, M.A. Mittleman, A. Peters, D. Siscovick, S.C. Smith Jr., L. Whitsel, J.D. Kaufman; and the American Heart Association Council on Epidemiology and Prevention, Council on the Kidney in Cardiovascular Disease, and Council on Nutrition, Physical Activity and Metabolism. 2010. Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation 121:2331–2378. doi:10.1161/CIR.0b013e3181dbece1
  • Burnett, R.T., S. Bartlett, B. Jessiman, P. Blagden, P.R. Samson, S. Cakmak, D. Stieb, M. Raizenne, J.R. Brook, and T. Dann. 2005. Measuring progress in the management of ambient air quality: The case for population health. J. Toxicol. Environ. Health A 68:1289–1300. doi:10.1080/15287390590936157
  • Campen, M.J., A.K. Lund, S.K. Seilkop, and J.D. McDonald. 2013. Section 2. NPACT animal toxicologic study of cardiovascular effects of mixed vehicle emissions combined with non-vehicular particulate matter. In National Particle Component Toxicity (NPACT) Initiative Report on Cardiovascular Effects, 129–170. Research Report 178. Boston, MA: Health Effects Institute.
  • Chen, L.C., and M. Lippmann. 2013. NPACT Study 1. Subchronic Inhalation Exposure of Mice to Concentrated Ambient PM2.5 from Five Airsheds. In National Particle Component Toxicity (NPACT) Initiative: Integrated Epidemiologic and Toxicologic Studies of the Health Effects of Particulate Matter Components, 15–54. Research Report 177. Boston, MA: Health Effects Institute.
  • Clarke, R.W., B. Coull, U. Reinisch, P. Catalano, C.R. Killingsworth., P. Koutrakis, I. Kavouras, G.G. Krishna Murthy, J. Lawrence, E. Lovett, J.M. Wolfson, R.L. Verrier, and J.J. Godleski. 2000. Inhaled concentrated ambient particles are associated with hematologic and bronchoalveolar lavage changes in canines. Environ. Health Perspect. 108:1179–1187. doi:10.1289/ehp.001081179
  • Devlin, R.B., C.B. Smith, M.T. Schmitt, A.G. Rappold, A. Hinderliter, D. Graff, and M.S. Carraway. 2014. Controlled exposure of humans with metabolic syndrome to concentrated ultrafine ambient particulate matter causes cardiovascular effects. Toxicol. Sci. 140:61–72. doi:10.1093/toxsci/kfu063
  • Dominici, F., R.D. Peng, C.D. Barr, and M.L. Bell. 2010. Protecting human health from air pollution: Shifting from a single pollutant to a multi-pollutant approach. Epidemiology 21:187–194. doi:10.1097/EDE.0b013e3181cc86e8
  • Ghio A.J., J. Stoneheurner, J.K. McGee, and J.S. Kinsey. 1999. Sulfate content correlates with iron concentrations in ambient air pollution particles. Inhal. Toxicol. 11:293–307.
  • Godleski, J.J., A.C. Rohr, B.A. Coull, C.M. Kang, E.A. Diaz, and P. Koutrakis. 2011. Toxicological Evaluation of Realistic Emission Source Aerosols (TERESA): Summary and conclusions. Inhal. Toxicol. 23(Suppl. 2): 95–103. doi:10.3109/08958378.2011.604687
  • Godleski, J.J., R.L. Verrier, P. Koutrakis, P. Catalano, B. Coull, U. Reinisch, E.G. Lovett, J. Lawrence, G.G. Murthy, J.M. Wolfson, R.W. Clarke, B.D. Nearing, and C. Killingsworth. 2000. Mechanisms of Morbidity and Mortality from Exposure to Ambient Air Particles. Research Report 91. Boston, MA: Health Effects Institute.
  • Gordon, T., M. Lippmann, A. Nádas, and C. Hickey. 2013. NPACT Study 2. In Vitro and In Vivo Toxicity of Exposure to Coarse, Fine, and Ultrafine PM from Five Airsheds. In National Particle Component Toxicity (NPACT) Initiative: Integrated Epidemiologic and Toxicologic Studies of the Health Effects of Particulate Matter Components, 55–94. Research Report 177. Boston, MA: Health Effects Institute.
  • Grahame, T.J., R.J. Klemm, and R.B. Schlesinger. 2014. Public health and components of particulate matter: The changing assessment of black carbon: Critical review. J. Air Waste Manage. Assoc. 64:620–660. doi:10.1080/10962247.2014.912692
  • Greenbaum, D., and R. Shaikh. 2010. First steps toward multipollutant science for air quality decisions. Epidemiology 21:195–197. doi:10.1097/EDE.0b013e3181ccc52a
  • Health Effects Institute. 2001. Airborne Particles and Health: HEI Epidemiologic Evidence. HEI Perspectives. Cambridge, MA: Health Effects Institute.
  • Health Effects Institute. 2002. Understanding the Health Effects of Components of the Particulate Matter Mix: Progress and Next Steps. Boston, MA: Health Effects Institute.
  • Health Effects Institute. 2013. Understanding the Health Effects of Ambient Ultrafine Particles. Boston MA: Health Effects Institute.
  • Hoek, G., R.M. Krishnan, R. Beelen, A. Peters, B. Ostro, B. Brunekreef, and J.D. Kaufman. 2013. Long-term air pollution exposure and cardio-respiratory mortality: A review. Environ. Health 12:43. doi:10.1186/1476-069X-12-43
  • Huang Y.C., A.G. Rappold., D.W. Graff, A.J. Ghio, and R.B. Devlin. 2012. Synergistic effects of exposure to concentrated ambient fine pollution particles and nitrogen dioxide in humans. Inhal. Toxicol. 24:790–797. doi:10.3109/08958378.2012.718809
  • Ito, K., Z. Ross, J. Zhou, A. Nádas, M. Lippmann, and G.D. Thurston. 2013. NPACT Study 3. Time-Series Analysis of Mortality, Hospitalizations, and Ambient PM2.5 and Its Components. In National Particle Component Toxicity (NPACT) Initiative: Integrated Epidemiologic and Toxicologic Studies of the Health Effects of Particulate Matter Components, 95–126. Research Report 177. Boston, MA: Health Effects Institute.
  • Johns, D.O., L. W. Stanek, K. Walker, S. Benromdhane, B. Hubbell, M. Ross, R.B. Devlin, D.L. Costa, and D.S. Greenbaum. 2012. Practical advancement of multipollutant scientific and risk assessment approaches for ambient air pollution. Environ. Health Perspect. 120:1238–1242. doi:10.1289/ehp.1204939
  • Kamal, A.S., A.C. Rohr, B. Mukherjee, M. Morishita, G.J. Keeler, J.R. Harkema, and J.G. Wagner. 2011. PM2.5-induced changes in cardiac function of hypertensive rats depend on wind direction and specific sources in Steubenville, Ohio. Inhal. Toxicol. 23:417–430. doi:10.3109/08958378.2011.580387
  • Khalek, I.A., T.L. Bougher, P.M. Merritt, and B. Zielinska. 2011. Regulated and unregulated emissions from highway heavy-duty diesel engines complying with U.S. Environmental Protection Agency 2007 emissions standards. J. Air Waste Manage. Assoc. 61:427–442. doi:10.3155/1047-3289.61.4.427
  • Kleinman, M.T., C. Sioutas, J.R. Froines, E. Fanning, A. Hamade, L. Mendez, D. Meacher, and M. Oldham. 2007. Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. Inhal. Toxicol. 19(Suppl. 1):117–126. doi:10.1080/08958370701495345
  • Krewski, D., M. Jerrett, R.T. Burnett, R. Ma, E. Hughes, Y. Shi, M.C. Turner, C.A. Pope III, G. Thurston, E.E. Calle, and M.J. Thun. 2009. Extended Follow-up and Spatial Analysis of the American Cancer Society Study Linking Particulate Air Pollution and Mortality. Research Report 140. Boston, MA: Health Effects Institute.
  • Laden, F., L.M. Neas, D.W. Dockery, and J. Schwartz. 2000. Association of fine particulate matter from different sources with daily mortality in six U.S. cities. Environ. Health Perspect. 108:941–947. doi:10.1289/ehp.00108941
  • Lepeule, J., F. Laden, D. Dockery, and J. Schwartz. 2012. Chronic exposure to fine particles and mortality: An extended follow-up of the Harvard Six Cities Study from 1974 to 2009. Environ. Health Perspect. 120:965–970. doi:10.1289/ehp.1104660
  • Levy, J.I., D. Diez, Y. Dou, C.D. Barr, and F. Dominici. 2012. A meta-analysis and multisite time-series analysis of the differential toxicity of major fine particulate matter constituents. Am. J. Epidemiol. 175:1091–1099. doi:10.1093/aje/kwr457
  • Lippmann, M. 2014. Toxicological and epidemiological studies of cardiovascular effects of ambient air fine particulate matter (PM2.5) and its chemical components: Coherence and public health implications. Crit. Rev. Toxicol. 44:299–347. doi:10.3109/10408444.2013.861796
  • Lippmann, M., L.C. Chen, T. Gordon, K. Ito, and G.D. Thurston. 2013. National Particle Component Toxicity (NPACT) Initiative: Integrated epidemiologic and toxicologic studies of the health effects of particulate matter components. Research Report 177. Boston, MA: Health Effects Institute.
  • Lippmann, M., K. Ito, A. Nádas, and R.T. Burnett. 2000. Association of Particulate Matter Components with Daily Mortality and Morbidity in Urban Populations. Research Report 95. Boston, MA: Health Effects Institute.
  • Mauderly, J.L. 2014. The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: I. Background, experimental strategy and critique. Inhal. Toxicol. 26:643–650. doi:10.3109/08958378.2014.923546
  • Mauderly, J.L., E.G. Barrett, K.C. Day, A.P. Gigliotti, J.D. McDonald, K.S. Harrod, A.K. Lund, M.D. Reed, J.C. Seagrave, M.J. Campen, and S.K. Seilkop. 2014a. The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: II. Comparison of responses to diesel and gasoline engine exhausts, hardwood smoke and simulated downwind coal emissions. Inhal. Toxicol. 26:651–667. doi:10.3109/08958378.2014.925523
  • Mauderly, J.L., D. Kracko, J. Brower, M. Doyle-Eisele, J.D. McDonald, A.K. Lund, and S.K. Seilkop. 2014b. The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: IV. Vascular effects of repeated inhalation exposure to a mixture of five inorganic gases. Inhal. Toxicol. 26:691–696. doi:10.3109/08958378.2014.947448
  • Mauderly, J.L., and S.K. Seilkop. 2014. The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: III. Components of diesel and gasoline engine exhausts, hardwood smoke and simulated downwind coal emissions driving non-cancer biological responses in rodents. Inhal. Toxicol. 26:668–690. doi:10.3109/08958378.2014.920440
  • Mirowsky, J., C. Hickey, L. Horton, M. Blaustein, K. Galdanes, R.E. Peltier, S. Chillrud, L.C. Chen, J. Ross, A. Nadas, M. Lippmann, and T. Gordon. 2013. The effect of particle size, location and season on the toxicity of urban and rural particulate matter. Inhal. Toxicol. 25:747–757. doi:10.3109/08958378.2013.846443
  • Oakes, M., L. Baxter, and T.C. Long. 2014. Evaluating the application of multipollutant exposure metrics in air pollution health studies. Environ. Int. 69:90–99. doi:10.1016/j.envint.2014.03.030
  • Oberdörster, G., J.N. Finkelstein, C. Johnston, R. Gelein, C. Cox, R. Baggs, and A.C.P. Elder. 2000. Acute Pulmonary Effects of Ultrafine Particles in Rats and Mice. Research Report 96. Boston, MA: Health Effects Institute.
  • Ostro, B., M. Lipsett, P. Reynolds, D. Goldberg, A. Hertz, C. Garcia, K.D. Henderson, and L. Bernstein. 2010. Long-term exposure to constituents of fine particulate air pollution and mortality: Results from the California Teachers Study. Environ. Health Perspect. 118:363–369. doi:10.1289/ehp.0901181
  • Pachon, J.E., S. Balachandran, Y. Hu, J.A. Mulholland, L.A. Darrow, J.A. Sarnat, P.E. Tolbert, and A.G. Russell. 2012. Development of outcome-based, multipollutant mobile source indicators. J. Air Waste Manage. Assoc. 62:431–442. doi:10.1080/10473289.2012.656218
  • Papapostolou, V., J.E. Lawrence, E.A. Diaz, J.M. Wolfson, S.T. Ferguson, M.S. Long, J.J. Godleski, and P. Koutrakis. 2011. Laboratory evaluation of a prototype photochemical chamber designed to investigate the health effects of fresh and aged vehicular exhaust emissions. Inhal. Toxicol. 23:495–505. doi:10.3109/08958378.2011.587034
  • Park, E.S., P.K. Hopke, M.S. Oh, E. Symanski, D. Han, and C.H. Spiegelman. 2014. Assessment of source-specific health effects associated with an unknown number of major sources of multiple air pollutants: A unified Bayesian approach. Biostatistics 15:484–497. doi:10.1093/biostatistics/kxu004
  • Pekkanen, J., K.L. Timonen, J. Ruuskanen, A. Reponen, and A. Mirme. 1997. Effects of ultrafine and fine particles in urban air on peak expiratory flow among children with asthmatic symptoms. Environ. Res. 74:24–33. doi:10.1006/enrs.1997.3750
  • Peters, A., H.E. Wichmann, T. Tuch, J. Heinrich, and J. Heyder. 1997. Respiratory effects are associated with the number of ultra-fine particles. Am. J. Respir. Crit. Care Med. 155:1376–1383. doi:10.1164/ajrccm.155.4.9105082
  • Pope, C.A., III, M. Ezzati, and D.W. Dockery. 2013. Fine particulate air pollution and life expectancies in the United States: The role of influential observations. J. Air Waste Manage. Assoc. 63:129–132. doi:10.1080/10962247.2013.760353
  • Riediker, M., R.B. Devlin, T.R. Griggs, M.C. Herbst, P.A. Bromberg, R.W. Williams, and W.E. Cascio. 2004. Cardiovascular effects in patrol officers are associated with fine particulate matter from brake wear and engine emissions. Particle Fibre Toxicol. 1(1):2. doi:10.1186/1743-8977-1-2
  • Rubasinghege, G., R.W. Lentz, M.M. Scherer, and V.H. Grassian. 2010. Simulated atmospheric processing of iron oxy-hydroxide minerals at low pH: Roles of particle size and acid anion in iron dissolution. Proc. Natl. Acad. Sci. U. S. A. 107:6628–6633. doi:10.1073/pnas.0910809107
  • Sexton, K.G., H.E. Jeffries, M. Jang, R.M. Kamens, M. Doyle, I. Voicu, and I. Jaspers. 2004. Photochemical products in urban mixtures enhance inflammatory responses in lung cells. Inhal. Toxicol. 16(Suppl 1):107–14. doi:10.1080/08958370490443196
  • Sun, Z., Y. Tao, S. Li, K.K. Ferguson, J.D. Meeker, S.K Park, S.A. Batterman, and B. Mukherjee. 2013. Statistical strategies for constructing health risk models with multiple pollutants and their interactions: Possible choices and comparisons. Environ. Health 12:85. doi:10.1186/1476-069X-12-85
  • Stanek, L.W., J.D. Sacks, S.J. Dutton, and J.J.B. Dubois. 2011. Attributing health effects to apportioned components and sources of particulate matter: An evaluation of collective results. Atmos. Environ. 45:5655–5663. doi:10.1016/j.atmosenv.2011.07.023
  • Thurston, G.D., K. Ito, R. Lall, R.T. Burnett, M.C. Turner, D. Krewski, Y. Shi, M. Jerrett, S.M. Gapstur, W.R. Diver, and C.A. Pope III. 2013. NPACT Study 4. Mortality and Long-Term Exposure to PM2.5 and Its Components in the American Cancer Society’s Cancer Prevention Study II Cohort. In National Particle Component Toxicity (NPACT) Initiative: Integrated Epidemiologic and Toxicologic Studies of the Health Effects of Particulate Matter Components, 127–166. Research Report 177. Boston, MA: Health Effects Institute.
  • U.S. Environmental Protection Agency Office of Research and Development. 2004. Air Quality Criteria for Particulate Matter, Volume II. EPA/600/P-99/ 002bF. Research Triangle Park, NC: U.S. Environmental Protection Agency.
  • U.S. Environmental Protection Agency Office of Air Quality Planning and Standards Air Quality Assessment Division. 2012. Near-Road NO2 Monitoring Technical Assistance Document. EPA-454/B-12-002. Research Triangle Park, NC: U.S. Environmental Protection Agency.
  • Utell, M.J., and M.W. Frampton. 2000. Acute health effects of ambient air pollution: The ultrafine particle hypothesis. J. Aerosol. Med. 13:355–359. doi:10.1089/jam.2000.13.355
  • Vedal, S., M.J. Campen, J.D. McDonald, T.V. Larson, P.D. Sampson, L. Sheppard, C.D. Simpson, and A.A. Szpiro. 2013a. National Particle Component Toxicity (NPACT) Initiative Report on Cardiovascular Effects. Research Report 178. Boston, MA: Health Effects Institute.
  • Vedal, S., S.Y. Kim, K.A. Miller, J.R. Fox, S. Bergen, T. Gould, J.D. Kaufman, T.V. Larson, P.D. Sampson, L. Sheppard, C.D. Simpson., and A.A. Szpiro. 2013b. Section 1. NPACT epidemiologic study of components of fine particulate matter and cardiovascular disease in the MESA and WHI-OS cohorts. In National Particle Component Toxicity (NPACT) Initiative Report on Cardiovascular Effects, 9–128. Research Report 178. Boston, MA: Health Effects Institute.
  • Wagner, J.G., M. Morishita, G.J. Keeler, and J.R. Harkema. 2012. Divergent effects of urban particulate air pollution on allergic airway responses in experimental asthma: A comparison of field exposure studies. Environ. Health 11:45. doi:10.1186/1476-069X-11–45
  • Wang, M., R. Beelen, M. Stafoggia, O. Raaschou-Nielsen, Z.J. Andersen, B. Hoffmann, P. Fischer, D. Houthuijs, M. Nieuwenhuijsen, G. Weinmayr, P. Vineis, W.W. Xun, K. Dimakopoulou, E. Samoli, T. Laatikainen, T. Lanki, A.W. Turunen, B. Oftedal, P. Schwarze, G. Aamodt, J. Penell, U. De Faire, M. Korek, K. Leander, G Pershagen, N.L. Pedersen, C.G. Östenson, L. Fratiglioni, K.T. Eriksen, M. Sørensen, A. Tjønneland, B. Bueno-de-Mesquita, M. Eeftens, M.L. Bots, K. Meliefste, U. Krämer, J. Heinrich, D. Sugiri, T. Key, K. de Hoogh, K. Wolf, A. Peters, J. Cyrys, A. Jaensch, H. Concin, G. Nagel, M.Y. Tsai, H. Phuleria, A. Ineichen, N. Künzli, N. Probst-Hensch, E. Schaffner, A. Vilier, F. Clavel-Chapelon, C. Declerq, F. Ricceri, C. Sacerdote, A. Marcon, C. Galassi, E. Migliore, A. Ranzi, G. Cesaroni, C. Badaloni, F. Forastiere, M. Katsoulis, A. Trichopoulou, M. Keuken, A. Jedynska, I.M. Kooter, J. Kukkonen, R.S. Sokhi, B. Brunekreef, K. Katsouyanni, and G. Hoek. 2014. Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: Results from the ESCAPE and TRANSPHORM projects. Environ. Int. 66:97–106. doi:10.1016/j.envint.2014.01.026
  • Wichmann, H.E., C. Spix, T. Tuch, G. Wölke, A. Peters, J. Heinrich, W.G. Kreyling, and J. Heyder. 2000. Daily Mortality and Fine and Ultrafine Particles in Erfurt, Germany. Part I: Role of Particle Number and Particle Mass. Research Report 98. Boston, MA: Health Effects Institute.
  • Wong, C.M., A. Rabl, Q.T. Thach, Y.K. Chau, K.P. Chan, B.J. Cowling, H.K. Lai, T.H. Lam, S.M. McGhee, H.R. Anderson, and A.J. Hedley. 2012. Impact of the 1990 Hong Kong Legislation for Restriction on Sulfur Content in Fuel. Research Report 170. Boston, MA: Health Effects Institute.
  • World Health Organization. 2013. Review of Evidence on Health Aspects of Air Pollution—REVIHAAP Project: Final Technical Report. Bonn, Germany: WHO Regional Office for Europe, European Centre for Environment and Health.
  • Xu, X., X. Rao, T.Y. Wang, S.Y. Jiang, Z. Ying, C. Liu, A Wang, M. Zhong, J.A. Deiuliis, A. Maiseyeu, S. Rajagopalan, M. Lippmann, L.C. Chen, and Q. Sun. 2012. Effect of co-exposure to nickel and particulate matter on insulin resistance and mitochondrial dysfunction in a mouse model. Particle Fibre Toxicol. 9:40. doi:10.1186/1743-8977-9-40
  • Zielinska, B., S. Samy, J.D. McDonald, and J.C. Seagrave 2010. Atmospheric Transformation of Diesel Emissions. Research Report 147. Boston, MA: Health Effects Institute.

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