Twenty-four-hour postoperative orphenadrine and ketorolac infusion efficiently precedes orphenadrine-diclofenac infusion as an opioid-sparing analgesic modality after mastectomy

References

• Hooda R, Malik N, Pathak P, et al. Impact of postoperative pain on early initiation of breastfeeding and ambulation after cesarean section: a randomized trial. Breastfeed Med. 2023 Feb;18(2):132–137. doi: 10.1089/bfm.2022.0208
   PubMed Web of Science ®Google Scholar
• Tanggaard K, Hasselager R, Hølmich E, et al. Anterior quadratus lumborum block does not reduce postoperative opioid consumption following laparoscopic hemicolectomy: a randomized, double-blind, controlled trial in an ERAS setting. Reg Anesth Pain Med. 2023 Jan;48(1):7–13. doi: 10.1136/rapm-2022-103895.
   PubMedGoogle Scholar
• Li L, Chang Y, Losina E, et al. Association of reported NSAID adverse drug reactions with opioid prescribing following total joint arthroplasty. J Allergy Clin Immunol Pract. 2023 Mar 20;S2213-2198(23):00301–X. doi: 10.1016/j.jaip.2023.03.017
   Google Scholar
• Amelin A, Tereshchenko N, Gotovchikov A. Clinical experience with the use of a fixed combination of diclofenac and orphenadrine in the treatment of acute pain syndrome. Zh Nevrol Psikhiatr Im S S Korsakova. 2021;121(8):83–86. doi: 10.17116/jnevro202112108183
   PubMedGoogle Scholar
• Öztürk AA, Çevikelli T, Tilki E, et al. Ketorolac tromethamine loaded nano-spray dried nanoparticles: preparation, characterization, cell viability, COL1A1 Gene Simulation andDetermination of anti-inflammatory activity by in vivo HET-CAM assay. Curr Drug Deliv. 2023;20(6):830–840. doi: 10.2174/1567201820666230125144133
   PubMed Web of Science ®Google Scholar
• Naeem S, Barkat K, Shabbir M, Khalid I, Anjum I, Shamshad N, Mehmood Y, Khan D, Badshah S, Syed M, Afzal S, Abdullah Z. Fabrication of pH-responsive hydrogel blends of chondroitin sulfate/pluronic F-127 for the controlled release of ketorolac: its characterization and acute oral toxicity study. Drug Dev Ind Pharm. 2022 Nov;48(11):611–622. doi: 10.1080/03639045.2022.2150773
   PubMed Web of Science ®Google Scholar
• Saracino MA, Petio C, Vitali M, et al. Determination of orphenadrine plasma levels using HPLC with diode array detection and a novel solid-phase extraction procedure in psychiatric patients. J Pharm Biomed Anal. 2009 Oct 15;50(3):501–506. doi: 10.1016/j.jpba.2009.05.010
   PubMed Web of Science ®Google Scholar
• Leaver A, Refshauge K, Maher C, et al. Conservative interventions provide short-term relief for non-specific neck pain: a systematic review. J Physiother. 2010;56(2):73–85. doi: 10.1016/s1836-9553(10)70037-0
   PubMed Web of Science ®Google Scholar
• Gombotz H, Lochner R, Sigl R, et al. Opiate sparing effect of a fixed combination of diclofenac and orphenadrine after unilateral total hip arthroplasty: a double-blind, randomized, placebo-controlled, multicenter clinical trial. Wien Med Wochenschr. 2010 Nov;160(19–20):526–534. doi: 10.1007/s10354-010-0829-7
   PubMedGoogle Scholar
• Wetzel L, Zadrazil M, Paternostro-Sluga T, et al. Intravenous nonopioid analgesic drugs in chronic low back pain patients on chronic opioid treatment: a crossover, randomised, double-blinded, placebo-controlled study. Eur J Anaesthesiol. 2014 Jan;31(1):35–40. doi: 10.1097/EJA.0b013e328365ae28
   PubMed Web of Science ®Google Scholar
• Rugytė D, Gudaitytė J. Intravenous paracetamol in adjunct to intravenous ketoprofen for postoperative pain in children undergoing general surgery: a double-blinded randomized study. Med (Kaunas). 2019 Apr 1;55(4):86. doi: 10.3390/medicina55040086
   PubMed Web of Science ®Google Scholar
• Haffner M, Saiz JA, Nathe R, et al. Preoperative multimodal analgesia decreases 24-hour postoperative narcotic consumption in elective spinal fusion patients. Spine J. 2019 Nov;19(11):1753–1763. doi: 10.1016/j.spinee.2019.07.005
   PubMed Web of Science ®Google Scholar
• Ghai B, Grandhe RP, Kumar A, et al. Comparative evaluation of midazolam and ketamine with midazolam alone as oral premedication. Paediatr Anaesth. 2005;15(7):554–559. doi: 10.1111/j.1460-9592.2004.01523.x
   PubMed Web of Science ®Google Scholar
• Williamson A, Hoggart B. Pain a review of three commonly used pain rating scales. J Clin Nurs. 2005;14(7):798–804. doi: 10.1111/j.1365-2702.2005.01121.x
   PubMed Web of Science ®Google Scholar
• Sessler CN, Grap MJ, Ramsay MAE. Evaluating and monitoring analgesia and sedation in the intensive care unit. Crit Care. 2008;12(Suppl 3):S2. doi: 10.1186/cc6148
   PubMed Web of Science ®Google Scholar
• Watcha MF, White PF. Postoperative nausea and vomiting. Its aetiology, treatment, and prevention. Anesthesiology. 1992;77(1):162–184. doi: 10.1097/00000542-199207000-00023
   PubMed Web of Science ®Google Scholar
• Aitken RC. Measurement of feelings using visual analogue scales. Proc R Soc Med. 1969 Oct;62(10):989–993. doi: 10.1177/003591576906201005
   PubMedGoogle Scholar
• Kiselev DV, Lavrukhin VV. The use of a fixed combination of diclofenac and orphenadrine in the treatment of acute pain syndrome in patients with discogenic lumbosacral radiculopathy and lumboischialgia. Zh Nevrol Psikhiatr Im S S Korsakova. 2023;123(3):122–129. doi: 10.17116/jnevro2023123031122
   PubMedGoogle Scholar
• George N, Gurk-Turner C, Etcheson J, et al. The addition of diclofenac to a multimodal pain control regimen decreases postoperative pain and opioid consumption. Surg Technol Int. 2017 Dec 22;31:346–351.
   PubMedGoogle Scholar
• Sorokina L, Ryabova D, Koshek E, et al. Efficiency and safety of a fixed combination of orphenadrine and diclofenac for postoperative analgesia in cardiac surgery patients. Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(2):61–67. doi: 10.17116/jnevro202212202161
   PubMedGoogle Scholar
• Eremenko A, Sorokina L, Ryabova D, et al. Analgesic and opioid-sparing effects of a fixed combination of diclofenac and orphenadrine in the early postoperative period in cardiac surgery patients. Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(10):109–115. doi: 10.17116/jnevro2022122101109
   PubMedGoogle Scholar
• Zeiner S, Haider T, Zotti O, et al. Intravenous diclofenac and orphenadrine for the treatment of postoperative pain after remifentanil-based anesthesia: a double-blinded, randomized, placebo-controlled study. Wien Klin Wochenschr. 2023 Feb;135(3–4):67–74. doi: 10.1007/s00508-022-02131-x
   PubMed Web of Science ®Google Scholar
• Hasan SMF, Ahmed T, Talib N, et al. Pharmacokinetics of diclofenac sodium in normal man. Pak J Pharm Sci. 2005 January;18(1):18–24.
   PubMedGoogle Scholar
• Paiva Carvalho RD, Leonardo P, Mendes G, et al. Pharmacokinetic and pharmacodynamics of sodium diclofenac (Topical and IM) associated with laser photobiomodulation on skeletal muscle strain in rats. Inter J Of Photoenergy. 2019;Article ID:2782709. doi: 10.1155/2019/2782709
   Google Scholar
• Martinez L, Ekman E, Nakhla N. Perioperative opioid-sparing strategies: utility of conventional NSAIDs in adults. Clin Ther. 2019 Dec;41(12):2612–2628. Research Articles, Neurobiology of Disease. doi: 10.1016/j.clinthera.2019.10.002
   PubMed Web of Science ®Google Scholar
• McNicol E, Ferguson M, Schumann R. Single-dose intravenous ketorolac for acute postoperative pain in adults. Cochrane Database Syst Rev. 2021 May 17;5(5). CD013263. doi: 10.1002/14651858.CD013263.pub2.
   Google Scholar
• Lombana N, Falola R, Zolfaghari K, et al. Comparison of liposomal bupivacaine to a local analgesic cocktail for transversus abdominis plane blocks in abdominally based microvascular breast reconstruction. Plast Reconstr Surg. 2022 Sep 1;150(3):506e–515e. doi: 10.1097/PRS.0000000000009398
   PubMed Web of Science ®Google Scholar
• Wu M, Shih M, Hsu W, et al. Evaluation of a novel biodegradable thermosensitive keto-hydrogel for improving postoperative pain in a rat model. PLoS One. 2017 Oct 23;12(10):e0186784. doi: 10.1371/journal.pone.0186784
   PubMed Web of Science ®Google Scholar
• Zhang Y, Sun X, Liang J, et al. Observation of the analgesic effect of dexmedetomidine combined with ketorolac tromethamine in laparoscopic surgery under ERAS. Panminerva Med. 2020 Dec;62(4):280–281. doi: 10.23736/S0031-0808.19.03662-0
   PubMed Web of Science ®Google Scholar
• Shim J, Jun E, Bae J, et al. Intraoperative multimodal analgesic bundle containing dexmedetomidine and ketorolac may improve analgesia after robot-assisted prostatectomy in patients receiving rectus sheath blocks. Asian J Surg. 2022 Mar;45(3):860–866. doi: 10.1016/j.asjsur.2021.07.043
   PubMed Web of Science ®Google Scholar
• Klifto K, Elhelali A, Payne R, et al. Perioperative systemic nonsteroidal anti-inflammatory drugs (NSAIDs) in women undergoing breast surgery. Cochrane Database Syst Rev. 2021 Nov 9;11(11). CD013290. doi: 10.1002/14651858.CD013290.pub2.
   PubMedGoogle Scholar
• Altman R, Bosch B, Brune K, et al. Advances in NSAID development: evolution of diclofenac products using pharmaceutical technology. Drugs. 2015;75(8):859–877. doi: 10.1007/s40265-015-0392-z
   PubMed Web of Science ®Google Scholar
• Singh P, Rastogi S, Bansal M, et al. A prospective study to assess the levels of interleukin-6 following administration of diclofenac, ketorolac and tramadol after surgical removal of lower third molars. J Maxillofac Oral Surg. 2015 Jun;14(2):219–225. doi: 10.1007/s12663-013-0609-1
   PubMedGoogle Scholar
• Smith C, Soti S, Jones T, et al. Non-steroidal anti-inflammatory drugs are Caspase Inhibitors. Cell Chem Biol. 2017 Mar 16;24(3):281–292. doi: 10.1016/j.chembiol.2017.02.003
   PubMed Web of Science ®Google Scholar
• Wu M, Shih M, Hsu W, et al. Evaluation of a novel biodegradable thermosensitive keto-hydrogel for improving postoperative pain in a rat model. PLoS One. 2017 Oct 23;12(10):e0186784. doi: 10.1371/journal.pone.0186784
   PubMed Web of Science ®Google Scholar
• Bertens C, Gijs M, Dias A, et al. Pharmacokinetics and efficacy of a ketorolac-loaded ocular coil in New Zealand white rabbits. Drug Deliv. 2021 Dec;28(1):400–407. doi: 10.1080/10717544.2021.1883157
   PubMed Web of Science ®Google Scholar
• Lee JH, Chung HS, Moon SY, et al. Effect of preoperative eyedrops on cytokine concentrations in aqueous humor of patients undergoing femtosecond laser-assisted cataract surgery. Graefes Arch Clin Exp Ophthalmol. 2022 Mar;260(3):885–891. doi: 10.1007/s00417-021-05428-1
   PubMed Web of Science ®Google Scholar