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Journal of Chemotherapy Volume 2, 1990 - Issue 2
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Original Articles

Multimodal Biochemical Modulation of 5-Fluorouracil Activity in Advanced Colorectal Cancer with Allopurinol, Folinic Acid and Dipyridamol

N. TsavarisSecond Department of Medical Oncology, «Metaxas» Cancer Hospital, Piraeus 18537, Greece.
,
A. ZinelisSecond Department of Medical Oncology, «Metaxas» Cancer Hospital, Piraeus 18537, Greece.
,
N. KarvounisSecond Department of Medical Oncology, «Metaxas» Cancer Hospital, Piraeus 18537, Greece.
,
D. BeldecosSecond Department of Medical Oncology, «Metaxas» Cancer Hospital, Piraeus 18537, Greece.
,
N. MylonacisSecond Department of Medical Oncology, «Metaxas» Cancer Hospital, Piraeus 18537, Greece.
,
N. ZamanisSecond Department of Medical Oncology, «Metaxas» Cancer Hospital, Piraeus 18537, Greece.
,
Ch. BacoyannisSecond Department of Medical Oncology, «Metaxas» Cancer Hospital, Piraeus 18537, Greece.
,
P. ValilisSecond Department of Medical Oncology, «Metaxas» Cancer Hospital, Piraeus 18537, Greece.
,
A. AntonopoulosSecond Department of Medical Oncology, «Metaxas» Cancer Hospital, Piraeus 18537, Greece.
&
P. KosmidisSecond Department of Medical Oncology, «Metaxas» Cancer Hospital, Piraeus 18537, Greece.
 show all
Pages 123-126 | Published online: 14 Jul 2016

References

  • Beyer WA. New vistas for leucovorin in cancer chemotherapy. Cancer 1989; 63: 995–1007.
  • Machover D, Goldschmidt E, Chellet P, et al. Treatment of advanced colorectal and gastric adenocarcinomas with 5-fluorouracil and high dose folinic acid. J Clin Oncol 1986; 4: 685–696.
  • Pinedo HM, Peters GFJ. Fluorouracil: biochemistry and pharmacology. J Clin Oncol 1988; 6: 1653–1664.
  • Howell SB, Graig EP, Wally EW. Effect of allopurinol on the toxicity of high dose 5-fluorouracil administered by intermittent bolus injection. Cancer 1983; 51: 220–225.
  • Tsavaris N, Karagiaouris P, Vonorta K, et al. Concomittent administration of allopurinol and high dose continuous infusion 5-fluorouracil. Oncology 1990; 47: 70–74.
  • Allen S, Fine C, Erlichman C. A phase II trial of 5-fluorouracil and folinic acid plus dipyridamol in patients with metastastic colorectal cancer. Proc Am Soc Clin Oncol 1987; 95: 373.
  • Fischer PH, Pamukcu R, Bittner G, Wilson KV. Enhancement of the sensitivity of human colon cancer cells to growth inhibition by acivicin achieved through inhibition of nucleic acid precusor salvage by dipyridamole. Cancer Res 1984; 44: 3355–3359.
  • Grem JL, Fischer PH. Augmentation of 5-fluorouracil cytotoxicity in human colon cancer cells by dipyridamol. Cancer Res 1985; 45: 2967–2972.
  • Grem JL, Fisher PH. Alteration of fluorouracil metabolism in human colon cancer cells by dipyridamol with a selective increase in fluorodeoxyuridine monophosphate levels. Cancer Res 1986; 46: 6191–6199.
  • Schmoll HJ, Schober C, Kohne-Wompner H, Stahl M, Hanauske AR, Poliwoda B, Wilke H. Pilot study of combination of 5-fluorouracil, high dose folinic acid plus dipyridamol in colorectal cancer. 13th Cong Eur Soc Med Oncol Abst 428 (P), 1988.
  • Schwartz J, Alberts D, Einspahr J, Peng YM, Spears P. Dipyridamol potentiation of FUDR activity against human colon cancer in vitro and in patients. Proc Am Soc Clin Oncol 1987; 83: 325.
  • Miller AB, Hoogstraten B, Staquet M, Winkler A. Reporting results of cancer treatment. Cancer 1981; 47: 207–214.

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