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Journal of Chemotherapy Volume 32, 2020 - Issue 5
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Brief Communication

L-GILZ binds and inhibits nuclear factor κB nuclear translocation in undifferentiated thyroid cancer cells

Maria Cristina MarchettiDepartment of Medicine, Section of Pharmacology, Medical School, University of Perugia, Perugia, ItalyView further author information
,
Lorenza CannarileDepartment of Medicine, Section of Pharmacology, Medical School, University of Perugia, Perugia, ItalyView further author information
,
Simona RonchettiDepartment of Medicine, Section of Pharmacology, Medical School, University of Perugia, Perugia, ItalyORCID Iconhttp://orcid.org/0000-0002-5639-4243View further author information
ORCID Icon,
Domenico V. DelfinoDepartment of Medicine, Section of Pharmacology, Medical School, University of Perugia, Perugia, ItalyView further author information
,
Carlo RiccardiDepartment of Medicine, Section of Pharmacology, Medical School, University of Perugia, Perugia, ItalyORCID Iconhttp://orcid.org/0000-0001-9257-3997View further author information
ORCID Icon &
Emira AyroldiDepartment of Medicine, Section of Pharmacology, Medical School, University of Perugia, Perugia, ItalyCorrespondence[email protected]
View further author information
Pages 263-267 | Received 09 Oct 2019, Accepted 06 Feb 2020, Published online: 18 Feb 2020

References

  • Xing M. Molecular pathogenesis and mechanisms of thyroid cancer. Nat Rev Cancer. 2013;13(3):184–199.
  • Fagin JA. Perspective: lessons learned from molecular genetic studies of thyroid cancer–insights into pathogenesis and tumor-specific therapeutic targets. Endocrinology. 2002;143(6):2025–2028.
  • Knauf JA, Fagin JA. Role of MAPK pathway oncoproteins in thyroid cancer pathogenesis and as drug targets. Curr Opin Cell Biol. 2009;21(2):296–303.
  • Rezatabar S, Karimian A, Rameshknia V, Parsian H, Majidinia M, Kopi TA, et al. RAS/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression. J Cell Physiol. 2019; 27:14951–14965.
  • Taniguchi K, Karin M. NF-kappaB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018;18(5):309–324.
  • Pires BRB, Silva R, Ferreira GM, Abdelhay E. NF-kappaB: two sides of the same coin. Genes (Basel). 2018; 9(1):24.
  • Volpe V, Raia Z, Sanguigno L, Somma D, Mastrovito P, Moscato F, Mellone S, Leonardi A, Pacifico F. NGAL controls the metastatic potential of anaplastic thyroid carcinoma cells. J Clin Endocrinol Metab. 2013;98(1):228–235.
  • Giuliani C, Bucci I, Napolitano G. The role of the transcription factor nuclear factor-kappa B in thyroid autoimmunity and cancer. Front Endocrinol (Lausanne)). 2018; 9:471.
  • Ayroldi E, Riccardi C. Glucocorticoid-induced leucine zipper (GILZ): a new important mediator of glucocorticoid action. Faseb J. 2009; 23(11):3649–3658.
  • Cannarile L, Delfino DV, Adorisio S, Riccardi C, Ayroldi E. Implicating the role of GILZ in glucocorticoid modulation of T-cell activation. Front Immunol. 2019; 10:1823
  • Ayroldi E, Petrillo MG, Marchetti MC, Cannarile L, Ronchetti S, Ricci E, Cari L, Avenia N, Moretti S, Puxeddu E, et al. Long glucocorticoid-induced leucine zipper regulates human thyroid cancer cell proliferation. Cell Death Dis. 2018;9(3):305.
  • Ayroldi E, Zollo O, Bastianelli A, Marchetti C, Agostini M, Di Virgilio R, Riccardi C. GILZ mediates the antiproliferative activity of glucocorticoids by negative regulation of Ras signalling. J Clin Invest. 2007;117(6):1605–1615.
  • Bereshchenko O, Migliorati G, Bruscoli S, Riccardi C. Glucocorticoid-induced leucine zipper: a novel anti-inflammatory molecule. Front Pharmacol. 2019; 10:308
  • Bruscoli S, Velardi E, Di Sante M, Bereshchenko O, Venanzi A, Coppo M, Berno V, Mameli MG, Colella R, Cavaliere A, et al. Long glucocorticoid-induced leucine zipper (L-GILZ) protein interacts with Ras protein pathway and contributes to spermatogenesis control. J Biol Chem. 2012; 287(2):1242–1251.
  • Bruscoli S, Donato V, Velardi E, Di Sante M, Migliorati G, Donato R, Riccardi C. Glucocorticoid-induced leucine zipper (GILZ) and long GILZ inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids. J Biol Chem. 2010; 285(14):10385–10396.
  • Ayroldi E, Petrillo MG, Bastianelli A, Marchetti MC, Ronchetti S, Nocentini G, Ricciotti L, Cannarile L, Riccardi C. L-GILZ binds p53 and MDM2 and suppresses tumor growth through p53 activation in human cancer cells. Cell Death Differ. 2015; 22(1):118–130.
  • Ayroldi E, Cannarile L, Delfino DV, Riccardi C. A dual role for glucocorticoid-induced leucine zipper in glucocorticoid function: tumor growth promotion or suppression?. Cell Death Dis. 2018; 9 (5):463.
  • Ayroldi E, Marchetti C, Riccardi C. The novel partnership of L-GILZ and p53: a new affair in cancer? Mol Cell Oncol. 2014; 2(2):e 975087.
  • Le F, Zhang JY, Liu W, Huang XM, Luo WZ. The levels of NF-kappaB p50 and NF-kappaB p65 play a role in thyroid carcinoma malignancy in vivo. J Int Med Res. 2018; 46(10):4092–4099.
  • Zhou D, Li Z, Bai X. BRAFV600E and RET/PTC promote proliferation and migration of papillary thyroid carcinoma cells in vitro by regulating Nuclear Factor-kappaB. Med Sci Monit. 2017; 23:5321–5329.
  • Faria M, Matos P, Pereira T, Cabrera R, Cardoso BA, Bugalho MJ, Silva AL. RAC1b overexpression stimulates proliferation and NF-kB-mediated anti-apoptotic signaling in thyroid cancer cells. PLoS One. 2017; 12(2):e 0172689.

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