Application of tumoroids derived from advanced colorectal cancer patients to predict individual response to chemotherapy

References

• Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA A Cancer J Clin. 2021;71(3):209–249.
   PubMed Web of Science ®Google Scholar
• Pernot S, Velut G, Kourie RH, et al. 5-FU or mitomycin C hepatic arterial infusion after failure of arterial oxaliplatin in patients with colorectal cancer unresectable liver metastases. Clin Res Hepatol Gastroenterol. 2018;42(3):255–260.
   PubMed Web of Science ®Google Scholar
• Byrne AT, Alferez DG, Amant F, et al. Interrogating open issues in cancer precision medicine with patient-derived xenografts. Nat Rev Cancer. 2017;17(4):254–268.
   PubMed Web of Science ®Google Scholar
• Smith JJ, Garcia-Aguilar J. Advances and challenges in treatment of locally advanced rectal cancer. J Clin Oncol. 2015;33(16):1797–1808.
   PubMed Web of Science ®Google Scholar
• Smith JD, Ruby JA, Goodman KA, et al. Nonoperative management of rectal cancer with complete clinical response after neoadjuvant therapy. Ann Surg. 2012;256(6):965–972.
   PubMed Web of Science ®Google Scholar
• Van de Wetering M, Francies HE, Francis JM, et al. Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell. 2015;161(4):933–945.
   PubMed Web of Science ®Google Scholar
• Dekkers JF, Berkers G, Kruisselbrink E, et al. Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis. Sci Transl Med. 2016;8(344):344ra84.
   PubMed Web of Science ®Google Scholar
• Ooft SN, Weeber F, Dijkstra KK, et al. Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients. Sci Transl Med. 2019;11(513):eaay2574.
   PubMed Web of Science ®Google Scholar
• Wensink GE, Elias SG, Mullenders J, et al. Patient-derived organoids as a predictive biomarker for treatment response in cancer patients. NPJ Precis Oncol. 2021;5(1):30. Apr 12
   PubMed Web of Science ®Google Scholar
• Vlachogiannis G, Hedayat S, Vatsiou A, et al. Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Science. 2018;359(6378):920–926.
   PubMed Web of Science ®Google Scholar
• Ganesh K, Wu C, O'Rourke KP, et al. A rectal cancer organoid platform to study individual responses to chemoradiation. Nat Med. 2019;25(10):1607–1614.
   PubMed Web of Science ®Google Scholar
• Fleming M, Ravula S, Tatishchev SF, et al. Colorectal carcinoma: pathologic aspects. J Gastrointest Oncol. 2012;3(3):153–173.
   PubMedGoogle Scholar
• Cercek A, Dos Santos Fernandes G, Roxburgh CS, et al. Mismatch repair-deficient rectal cancer and resistance to neoadjuvant chemotherapy. Clin Cancer Res. 2020;26(13):3271–3279.
   PubMed Web of Science ®Google Scholar
• Cristobal A, van den Toorn HWP, van de Wetering M, et al. Personalized proteome profiles of healthy and tumour human Colon organoids reveal both individual diversity and basic features of colorectal cancer. Cell Rep. 2017;18(1):263–274.
   PubMed Web of Science ®Google Scholar
• Sachs N, de Ligt J, Kopper O, et al. A living biobank of breast cancer organoids captures disease heterogeneity. Cell. 2018;172(1-2):373–386 e10.
   PubMed Web of Science ®Google Scholar
• Zehir A, Benayed R, Shah RH, et al. Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. Nat Med. 2017;23(6):703–713.
   PubMed Web of Science ®Google Scholar
• Venook AP, Niedzwiecki D, Lenz HJ, et al. Effect of First-Line chemotherapy combined with cetuximab or bevacizumab on overall survival in patients with KRAS Wild-Type advanced or metastatic colorectal cancer: a randomized clinical trial. JAMA. 2017;317(23):2392–2401.
   PubMed Web of Science ®Google Scholar
• Sato T, Vries RG, Snippert HJ, et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature. 2009;459(7244):262–265.
   PubMed Web of Science ®Google Scholar
• Nakano T, Ando S, Takata N, et al. Self-formation of optic cups and storable stratified neural retina from human ESCs. Cell Stem Cell. 2012;10(6):771–785. Jun 14
   PubMed Web of Science ®Google Scholar
• Lancaster MA, Renner M, Martin CA, et al. Cerebral organoids model human brain development and microcephaly. Nature. 2013;501(7467):373–379. Sep 19
   PubMed Web of Science ®Google Scholar
• Quadrato G, Nguyen T, Macosko EZ, et al. Cell diversity and network dynamics in photosensitive human brain organoids. Nature. 2017;545(7652):48–53. May 4
   PubMed Web of Science ®Google Scholar
• Paşca AM, Sloan SA, Clarke LE, et al. Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture. Nat Methods. 2015;12(7):671–678. Jul
   PubMed Web of Science ®Google Scholar
• Sakaguchi H, Kadoshima T, Soen M, et al. Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue. Nat Commun. 2015;6:8896 Nov 17
   PubMed Web of Science ®Google Scholar
• Koehler KR, Nie J, Longworth-Mills E, et al. Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells. Nat Biotechnol. 2017;35(6):583–589. Jun
   PubMed Web of Science ®Google Scholar
• Miller AJ, Dye BR, Ferrer-Torres D, et al. Generation of lung organoids from human pluripotent stem cells in vitro. Nat Protoc. 2019;14(2):518–540.
   PubMed Web of Science ®Google Scholar
• McCracken KW, Catá EM, Crawford CM, et al. Modelling human development and disease in pluripotent stem-cell-derived gastric organoids. Nature. 2014;516(7531):400–404.
   PubMed Web of Science ®Google Scholar
• Hu H, Gehart H, Artegiani B, et al. Long-term expansion of functional mouse and human hepatocytes as 3D organoids. Cell. 2018;175(6):1591–1606 e19.
   PubMed Web of Science ®Google Scholar
• Hohwieler M, Illing A, Hermann PC, et al. Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling. Gut. 2017;66(3):473–486.
   PubMed Web of Science ®Google Scholar
• Czerniecki SM, Cruz NM, Harder JL, et al. High throughput screening enhances kidney organoid differentiation from human pluripotent stem cells and enables automated multidimensional phenotyping. Cell Stem Cell. 2018;22(6):929–940 e4.
   PubMed Web of Science ®Google Scholar
• Karthaus WR, Iaquinta PJ, Drost J, et al. Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell. 2014;159(1):163–175.
   PubMed Web of Science ®Google Scholar
• Kale S, Biermann S, Edwards C, et al. Three-dimensional cellular development is essential for ex vivo formation of human bone. Nat Biotechnol. 2000;18(9):954–958.
   PubMed Web of Science ®Google Scholar
• Fujii M, Matano M, Toshimitsu K, et al. Human intestinal organoids maintain self-renewal capacity and cellular diversity in niche-inspired culture condition. Cell Stem Cell. 2018;23(6):787–793 e6.
   PubMed Web of Science ®Google Scholar
• Bleijs M, Wetering M, Clevers H, et al. Xenograft and organoid model systems in cancer research. Embo J. 2019;38(15):e101654.
   PubMed Web of Science ®Google Scholar
• Nanki K, Toshimitsu K, Takano A, et al. Divergent routes toward wnt and R-spondin niche independency during human gastric carcinogenesis. Cell. 2018;174(4):856–869 e17.
   PubMed Web of Science ®Google Scholar
• Smith RC, Tabar V. Constructing and deconstructing cancers using human pluripotent stem cells and organoids. Cell Stem Cell. 2019;24(1):12–24.
   PubMed Web of Science ®Google Scholar
• Sato T, Stange DE, Ferrante M, et al. Long-term expansion of epithelial organoids from human Colon, adenoma, adenocarcinoma, and barrett’s epithelium. Gastroenterology. 2011;141(5):1762–1772.
   PubMed Web of Science ®Google Scholar
• Fujii M, Shimokawa M, Date S, et al. A colorectal tumour organoid library demonstrates progressive loss of niche factor requirements during tumorigenesis. Cell Stem Cell. 2016;18(6):827–838.
   PubMed Web of Science ®Google Scholar
• Qu Y, Han B, Gao B, et al. Differentiation of human induced pluripotent stem cells to mammary-like organoids. Stem Cell Reports. 2017;8(2):205–215.
   PubMed Web of Science ®Google Scholar
• Broutier L, Mastrogiovanni G, Verstegen MM, Francies HE, et al. Human primary liver cancer-derived organoid cultures for disease modeling and drug screening. Nat Med. 2017;23(12):1424–1435.
   PubMed Web of Science ®Google Scholar
• Kim M, Mun H, Sung CO, et al. Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening. Nat Commun. 2019;10(1):3991 Sep 5
   PubMedGoogle Scholar
• Boj SF, Hwang CI, Baker LA, et al. Organoid models of human and mouse ductal pancreatic cancer. Cell. 2015;160(1-2):324–338. Jan 15
   PubMed Web of Science ®Google Scholar
• Boretto M, Maenhoudt N, Luo X, et al. Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening. Nat Cell Biol. 2019;21(8):1041–1051.
   PubMed Web of Science ®Google Scholar
• Seidlitz T, Merker SR, Rothe A, et al. Human gastric cancer modelling using organoids. Gut. 2019;68(2):207–217.
   PubMed Web of Science ®Google Scholar
• Gao D, Vela I, Sboner A, et al. Organoid cultures derived from patients with advanced prostate cancer. Cell. 2014;159(1):176–187.
   PubMed Web of Science ®Google Scholar
• Kopper O, de Witte CJ, Lõhmussaar K, et al. An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity. Nat Med. 2019;25(5):838–849.
   PubMed Web of Science ®Google Scholar
• Lee SH, Hu W, Matulay JT, et al. Tumor evolution and drug response in patient-derived organoid models of bladder cancer. Cell. 2018;173(2):515–528 e17.
   PubMed Web of Science ®Google Scholar
• Calandrini C, Schutgens F, Oka R, et al. An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity. Nat Commun. 2020;11(1):1310.
   PubMed Web of Science ®Google Scholar
• Jacob F, Salinas RD, Zhang DY, et al. A patient-derived glioblastoma organoid model and biobank recapitulates inter- and intra-tumoral heterogeneity. Cell. 2020;180(1):188–204 e22.
   PubMed Web of Science ®Google Scholar
• Lee DF, Su J, Kim HS, et al. Modeling familial cancer with induced pluripotent stem cells. Cell. 2015;161(2):240–254.
   PubMed Web of Science ®Google Scholar
• Li X, Francies HE, Secrier M, et al. Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics. Nat Commun. 2018;9(1):2983.
   PubMedGoogle Scholar
• Yao Y, Xu X, Yang L, et al. Patient-derived organoids predict chemoradiation responses of locally advanced rectal cancer. Cell Stem Cell. 2020;26(1):17–26 e6.
   PubMed Web of Science ®Google Scholar
• Dekkers JF, Wiegerinck CL, de Jonge HR, et al. A functional CFTR assay using primary cystic fibrosis intestinal organoids. Nat Med. 2013;19(7):939–945. Jul
   PubMed Web of Science ®Google Scholar
• Boj SF, Vonk AM, Statia M, et al. Forskolin-induced swelling in intestinal organoids: an in vitro assay for assessing drug response in cystic fibrosis patients. J Vis Exp. 2017;(120):55159. Feb 11
   PubMed Web of Science ®Google Scholar
• Tiriac H, Belleau P, Engle DD, et al. Organoid profiling identifies common responders to chemotherapy in pancreatic cancer. Cancer Discov. 2018;8(9):1112–1112.
   PubMed Web of Science ®Google Scholar
• Dutta D, Heo I, Clevers H. Disease modeling in stem cell-derived 3D organoid systems. Trends Mol Med. 2017;23(5):393–410.
   PubMed Web of Science ®Google Scholar
• Jin MZ, Han RR, Qiu GZ, et al. Organoids: an intermediate modeling platform in precision oncology. Cancer Lett. 2018;414:174–180. Feb 1
   PubMed Web of Science ®Google Scholar
• Yokota E, Iwai M, Yukawa T, et al. Clinical application of a lung cancer organoid (tumoroid) culture system. NPJ Precis Oncol. 2021;5(1):29. Apr 12
   PubMed Web of Science ®Google Scholar
• Bregenzer M, Horst E, Mehta P, et al. The role of the tumour microenvironment in CSC enrichment and chemoresistance: 3D Co-culture methods. Methods Mol Biol. 2022;2424:217–245.
   PubMedGoogle Scholar
• Dzobo K. Taking a full snapshot of cancer biology: deciphering the tumour microenvironment for effective cancer therapy in the oncology clinic. OMICS. 2020;24(4):175–179. Apr
   PubMed Web of Science ®Google Scholar
• Dzobo K, Rowe A, Senthebane DA, et al. Three-dimensional organoids in cancer research: the search for the holy grail of preclinical cancer modeling. OMICS. 2018;22(12):733–748. Dec
   PubMed Web of Science ®Google Scholar
• Zanoni M, Cortesi M, Zamagni A, et al. Modeling neoplastic disease with spheroids and organoids. J Hematol Oncol. 2020;13(1):97 Jul 16
   PubMed Web of Science ®Google Scholar