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Journal of Chemotherapy Volume 35, 2023 - Issue 7
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Antimicrobial Original Research Papers

Population pharmacokinetic model-based dosing proposal for ampicillin prophylaxis in cardiac surgery patients with cardiopulmonary bypass

Karel Urbáneka Department of Pharmacology, Faculty of Medicine and Dentistry, Palacký University and University Hospital, Olomouc, Czech RepublicView further author information
,
Petr Šantavýb Department of Cardiac Surgery, Faculty of Medicine and Dentistry, Palacký University and University Hospital, Olomouc, Czech RepublicView further author information
,
Ondřej Zuščichb Department of Cardiac Surgery, Faculty of Medicine and Dentistry, Palacký University and University Hospital, Olomouc, Czech RepublicView further author information
,
Vendula Kubíčkováa Department of Pharmacology, Faculty of Medicine and Dentistry, Palacký University and University Hospital, Olomouc, Czech RepublicView further author information
,
Danica Michaličkovác Department of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech RepublicView further author information
,
Ondřej Slanařc Department of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech RepublicView further author information
&
Martin Šímac Department of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech RepublicCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6541-738XView further author information
ORCID Icon show all
Pages 614-622 | Received 28 Sep 2022, Accepted 13 Jan 2023, Published online: 30 Jan 2023

References

  • Betrosian AP, Douzinas EE. Ampicillin-sulbactam: an update on the use of parenteral and oral forms in bacterial infections. Expert Opin Drug Metab Toxicol. 2009;5(9):1099–1112.
  • Grayson ML, Cosgrove S, Crowe SM. Kucers’ the use of antibiotics: a clinical review of antibacterial, antifungal, antiparasitic, and antiviral drugs. 7th ed. Boca Raton (FL): CRC Press; 2018.
  • State Institute for Drug Control of Czech Republic. Unasyn – Summary of Product Characteristics. [updated Dec 11, 2020; cited May 25, 2022]. Available from: https://www.sukl.cz/modules/medication/detail.php?code=0016600&tab=texts.
  • Engelman R, Shahian D, Shemin R, et al. The Society of thoracic surgeons practice guideline series: antibiotic prophylaxis in cardiac surgery, part II: antibiotic choice. Ann Thorac Surg. 2007;83(4):1569–1576.
  • Lepelletier D, Bourigault C, Roussel JC, et al. Epidemiology and prevention of surgical site infections after cardiac surgery. Med Mal Infect. 2013;43(10):403–409.
  • Wildfeuer A, Muller V, Springsklee M, et al. Pharmacokinetics of ampicillin and sulbactam in patients undergoing heart surgery. Antimicrob Agents Chemother. 1991;35(9):1772–1776.
  • Yokoyama Y, Matsumoto K, Yamamoto H, et al. Pharmacokinetics of ampicillin-sulbactam and the renal function-based optimization of dosing regimens for prophylaxis in patients undergoing cardiovascular surgery. J Infect Chemother. 2012;18(6):878–882.
  • Yokoyama Y, Matsumoto K, Ikawa K, et al. Pharmacokinetics of prophylactic ampicillin-sulbactam and dosing optimization in patients undergoing cardiovascular surgery with cardiopulmonary bypass. Biol Pharm Bull. 2015;38(11):1817–1821.
  • Yokoyama Y, Matsumoto K, Ikawa K, et al. The pharmacokinetics of ampicillin-sulbactam in anuric patients: dosing optimization for prophylaxis during cardiovascular surgery. Int J Clin Pharm. 2016;38(4):771–775.
  • Wildschut ED, Ahsman MJ, Allegaert K, et al. Determinants of drug absorption in different ECMO circuits. Intensive Care Med. 2010;36(12):2109–2116.
  • Asada M, Nagata M, Mizuno T, et al. Effects of cardiopulmonary bypass on the disposition of cefazolin in patients undergoing cardiothoracic surgery. Pharmacol Res Perspect. 2018;6(6):e00440.
  • Santavy P, Kubickova V, Sima M, et al. Population pharmacokinetics of three alternative prophylactic antibiotics during cardiac surgery with extracorporeal circulation. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022. https://doi.org/10.5507/bp.2022.033
  • Kubickova V, Racova Z, Strojil J, et al. Separation of ampicillin on polar-endcapped phase: development of the HPLC method to achieve its correct dosage in cardiac surgery. AChrom. 2022. https://doi.org/10.1556/1326.2021.00957
  • Kubíčková V, Šantavý P, Urbánek K. Determination of ampicillin plasma concentrations in single-dose administration for cardiac surgery prophylaxis. Klin Farmakol Farm. 2022;36(1):4–7.
  • European Medicine Agency. Guideline on bioanalytical method validation. [updated July 21, 2011; cited July 28, 2022]. Available from: https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-bioanalytical-method-validation_en.pdf.
  • Soto E, Shoji S, Muto C, et al. Population pharmacokinetics of ampicillin and sulbactam in patients with community-acquired pneumonia: evaluation of the impact of renal impairment. Br J Clin Pharmacol. 2014;77(3):509–521.
  • Wong G, Briscoe S, McWhinney B, et al. Therapeutic drug monitoring of beta-lactam antibiotics in the critically ill: direct measurement of unbound drug concentrations to achieve appropriate drug exposures. J Antimicrob Chemother. 2018;73(11):3087–3094.
  • Scharf C, Liebchen U, Paal M, et al. The higher the better? Defining the optimal beta-lactam target for critically ill patients to reach infection resolution and improve outcome. J Intensive Care. 2020;8(1):86.
  • Adembri C, Ristori R, Chelazzi C, et al. Cefazolin bolus and continuous administration for elective cardiac surgery: improved pharmacokinetic and pharmacodynamic parameters. J Thorac Cardiovasc Surg. 2010;140(2):471–475.

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