51
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Total phenolic content, phytochemical profile and cytotoxic effects of endemic Alyssum floribundum (Brassicaceae) from Turkey

ORCID Icon, ORCID Icon & ORCID Icon
Received 05 Oct 2023, Accepted 03 Apr 2024, Published online: 10 May 2024

References

  • Adegoke AS, Jerry OV, Ademola OG. 2019. GC/MS analysis of phytochemical constituents in methanol extract of wood bark from Durio zibethinus Murr. Int J Med Plants Nat Prod. 5(3):1–11.
  • Adriani Astiti NP, Ramona Y. 2021. GC/MS analysis of active and applicable compounds in methanol extract of Sweet Star Fruit (Averrhoa carambola L.) leaves. Hayati J Biosci. 28(1):12–22. doi: 10.4308/hjb.28.1.12.
  • Ajilogba CF, Babalola Olubukola O. 2019. GC–MS analysis of volatile organic compounds from Bambara groundnut rhizobacteria and their antibacterial properties. World J Microbiol Biotechnol. 35(6):83. doi: 10.1007/s11274-019-2660-7.
  • Al-Shehbaz IA. 2012. A generic and tribal synopsis of the Brassicaceae (Cruciferae). Taxon. 61(5):931–954. doi: 10.1002/tax.615002.
  • Amel Z, Belyagoubi-Benhammou N, Nacéra G, Fethi T, Bekkara FA. 2016. Assessment of phytochemical composition and antioxidant properties of extracts from the leaf, stem, fruit and root of Pistacia lentiscus L. Int J Pharmacogn Phytochem Res. 8(4):627–633.
  • Arena P, Miceli N, Marino A, Davì F, Cavò E, Spadaro V, Raimondo FM, Cacciola F, Vinci RL, Mondello L, et al. 2023. comparative study on phenolic profile and biological activities of the aerial parts of Sinapis pubescens L. subsp. pubescens (Brassicaceae) wild from Sicily (Italy). Chem Biodivers. 20:e202300309.
  • Azimi AA, Hashemloian BD. 2017. Allelopathy and anti-mitotic effects of Cuscuta campestris and Cuscuta monogyna extracts on plant cell division. J Med Plants By-Products. 2:131–138.
  • Banakar P, Jayaraj M. 2018. GC/MS analysis of bioactive compounds from ethanolic leaf extract of Waltheria indica Linn. and their pharmacological activities. Int J Pharm Sci Res. 9(5):2005–2010.
  • Begum IF, Mohankumar R, Jeevan M, Ramani K. 2016. GC–MS analysis of bio-active molecules derived from Paracoccus pantotrophus FMR19 and the antimicrobial activity against bacterial pathogens and MDROs. Indian J Microbiol. 56(4):426–432. doi: 10.1007/s12088-016-0609-1.
  • Bekhouche K, Ozen T, Boussaha S, Koldas S, Yenigun S, Lassed S, Demirtas I, Benayache F, Benayache S, Zama D. 2018. Antioxidant, DNA-damage protection and anti-cancer properties of n-butanol extract of the endemic Perralderia coronopifolia. Bangladesh J Pharmacol. 13(1):82–89. doi: 10.3329/bjp.v13i1.34255.
  • Canturk Z, Kocabiyik E, Ozturk N, İlhan S. 2017. Evaluation of antioxidant and antiproliferative metabolites of Penicillium flavigenum isolated from hypersaline environment: Tuz (Salt) lake by Xcelligence Technology. Microbiology. 86(3):346–354. doi: 10.1134/S0026261717030055.
  • Cavò E, Fernanda Taviano M, Davì F, Cacciola F, Oulad El Majdoub Y, Mondello L, Ragusa M, Concett C, Merlino M, Verzera A, et al. 2022. Phenolic and volatile composition and antioxidant properties of the leaf extract of Brassica fruticulosa subsp. fruticulosa (Brassicaceae) growing wild in Sicily (Italy). Molecules. 27(9):2768.
  • Chatterjee S, Karmakar A, Azmi SA, Barik A. 2018. Antibacterial activity of long-chain primary alcohols from Solena amplexicaulis leaves. Proc Zool Soc. 71(4):313–319. doi: 10.1007/s12595-017-0208-0.
  • Demirtas I, Sahin A. 2013. Bioactive volatile content of the stem and root of Centaurea carduiformis DC. subsp carduiformis var. carduiformis. J Chem. 2013:1–6. doi: 10.1155/2013/125286.
  • Dudley TR. 1966. Ornamental madworts (Alyssum) and the correct name of the goldentuft Alyssum. Arnoldia. 26:33–45.
  • Ersan P, Sönmez Ö, Gözmen B. 2020. Microwave-assisted D-pinitol extraction from carob: application of Box–Behnken design. J Iran Chem Soc. 17(4):871–879. doi: 10.1007/s13738-019-01824-x.
  • Fahey JW, Zalcmann AT, Talalay P. 2001. The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry. 56(1):5–51. doi: 10.1016/s0031-9422(00)00316-2.
  • Florence Febronia SB, Santhi G. 2017. In vitro efficacy of piper betle leaf extract against Rhizoctonia solani causing damping off disease of Chilli. Int J Pharm Res Appl. 6(1):109–115.
  • Ganesh M, Mohankumar M. 2017. Extraction and identification of bioactive components in Sida cordata (Burm.f.) using gas chromatography–mass spectrometry. J Food Sci Technol. 54(10):3082–3091. doi: 10.1007/s13197-017-2744-z.
  • George LO, Radha H, Somasekaria BV. 2018. İn vitro anti-diabetic activity and GC/MS analysis of bioactive compounds present in the methanol extract of Kalanchoe pinnate. Indian J Chem. 57:1213–1221.
  • Godara P, Dulara BK, Barwer N, Chaudhary NS. 2019. Comparative GC–MS analysis of bioactive phytochemicals from different plant parts and Callus of Leptadenia reticulata Wight and Arn. Pharmacogn J. 11(1):129–140. doi: 10.5530/pj.2019.1.22.
  • Guner A. 2012, editor. A checklist of the flora of Turkey (vascular plants). Istanbul (Turkey): Namaş Nurtan Ambalaj ve Matbaacılık San. ve Tic. A.Ş.
  • Hema R, Kumaravel S, Alagusundaram K. 2011. GC/MS determination of bioactive components of Murraya koenigii. J Am Sci. 7(1):80–83.
  • Hlel TB, Belhadj F, Gül F, Altun M, Yağlıoğlu AŞ, Demirtaş I, Marzouki MN. 2017. Variations in the bioactive compounds composition and biological activities of Loofah (Luffa cylindrica) fruits in relation to maturation stages. Chem Biodivers. 14(10):e1700178. doi: 10.1002/cbdv.201700178.
  • Igwe KK, Nwankudu ON, Ijioma SN, Madubuike AJ, Achi NK. 2016. Screening for secondary metabolites in Huru crepitans bark ethanol extract using GC/MS analysis: a preliminary study approach. J Sci Tech Adv. 1(2):64–71.
  • Karthikeyan K, Dhanapal CK, Gopalakrishnan G. 2016. GC/MS analysis of petroleum ether extract of Alysicarpus monilifer - whole plant. Der Pharm Lett. 8(3):94–99.
  • Keskin D, Ceyhan N, Uğur A, Durgan Dbeys A. 2012. Antimicrobial activity and chemical constitutions of West Anatolian olive (Olea europaea L.) leaves. J Food Agric Eniviron. 10(2):99–102.
  • Khan IH, Javaid A. 2019. Antifungal, antibacterial and antioxidant components of ethyl acetate extract of Quinoa stem. Plant Prot. 3(3):125–130. doi: 10.33804/pp.003.03.3109.
  • Khan P, Akhtar N. 2022. Phytochemical investigations and development of ethosomal gel with Brassica oleraceae L. (Brassicaceae) extract: an innovative nano approach towards cosmetic and pharmaceutical industry. Ind Crops Prod. 183:114905. doi: 10.1016/j.indcrop.2022.114905.
  • Koç E, Üngördü A, Candan F. 2022. Antioxidant activities of Alyssum virgatum plant and its main components. Struct Chem. 33(1):267–279. doi: 10.1007/s11224-021-01856-1.
  • Koch MA, Kiefer C. 2006. Molecules and migration: biogeographical studies in cruciferous plants. Plant Syst Evol. 259(2-4):121–142. doi: 10.1007/s00606-006-0416-y.
  • Koch MA, Kiefer M, German DA, Al-Shehbaz IA, Franzke A, Mummenhoff K, Schmick R. 2012. BrassiBase: tools and biological resources to study characters and traits in the Brassicaceae. Taxon. 61(5):1001–1009. doi: 10.1002/tax.615007.
  • Krishnamoorthy K, Subramaniam P. 2014. Phytochemical profiling of leaf, stem, and tuber parts of Solena amplexicaulis (Lam.) Gandhi using GC/MS. Int Sch Res Notices. 2014:567409. doi: 10.1155/2014/567409.
  • Kuete V, Mbaveng AT, Zeino M, Fozing CD, Ngameni B, Kapche GDWF, Ngadjui BT, Efferth T. 2015. Cytotoxicity of three naturally occurring flavonoid derived compounds (artocarpesin, cycloartocarpesin and isobavachalcone) towards multi-factorial drug-resistant cancer cells. Phytomedicine. 22(12):1096–1102. doi: 10.1016/j.phymed.2015.07.006.
  • Lee YH, Choo C, Waisundara VY. 2015. Determination of the total antioxidant capacity and quantification of phenolic compounds of different solvent extracts of black mustard seeds (Brassica nigra). Int J Food Prop. 18(11):2500–2507. doi: 10.1080/10942912.2014.986331.
  • Malik B, Pirzadah TB, Tahir I, Abdin MZ, Rehman RU. 2016. Phytochemical studies on Cichorium intybus L. (chicory) from Kashmir Himalaya using GC/MS. J Pharm Res. 10(11):715–726.
  • Mamphiswana ND, Mashela PW, Mdee LK. 2010. Distribution of total phenolics and antioxidant activity in fruit, leaf, stem and root of Monsonia burkeana. Afr J Agric Res. 5(18):2570–2575.
  • Mart S. 2006. An ethnobotanical investigation of the natural plants using by inhabitants in Bahce and Hasanbeyli districts of Osmaniye Province [MSc thesis]. Cukurova (Turkey): Department of Biology, University Institute of Natural and Applied Sciences.
  • Meng-Ying LV, Jian-Bo S, Min W, Hong-Yan F, Zun-Jian Z, Feng-Guo X. 2016. Comparative analysis of volatile oils in the stems and roots of Ephedra sinica via GC/MS-based plant metabolomics. Chin J Nat Med. 14(2):0133–0140.
  • Moo-Huchin VM, Moo-Huchin MI, Estrada-León RJ, Cuevas-Gloryc L, Estrada-Motaa IA, Ortiz-Vázquezc E, Betancur-Anconad D, Sauri-Duchc E. 2015. Antioxidant compounds, antioxidant activity and phenolic content in peel from three tropical fruits from Yucatan, Mexico. Food Chem. 166:17–22. doi: 10.1016/j.foodchem.2014.05.127.
  • Moradi R, Ebrahimi S, Taravati A, Asrardel F, Khorasani HR, Aghajanpour M, Rezaizad M. 2017. Cytotoxic effects of the hydroalcoholic extract of Rorippa nasturtium aquaticum on hela cell line. Int Biol Biomed J. 3(2):73–79.
  • Musa AM, Ibrahim MA, Aliyu AB, Abdullahi MS, Tajuddeen N, Ibrahim H, Oyewale AO. 2015. Chemical composition and antimicrobial activity of hexane leaf extract of Anisopus mannii (Asclepiadaceae). J Intercult Ethnopharmacol. 4(2):129–133. doi: 10.5455/jice.20150106124652.
  • Nagaraja SK, Nayak S, Kumar RS. 2023. Phytochemical analysis, GC–MS profiling, and in vitro evaluation of biological applications of different solvent extracts of Leonotis nepetifolia (L.) R.Br. Flower Buds. Appl Biochem Biotechnol. 195(2):1197–1215. doi: 10.1007/s12010-022-04201-2.
  • Nidugala H, Avadhani R, Prabhu A, Basavaiah R, Kumar K. 2015. GC/MS characterization of n-hexane soluble compounds of Cyperus rotundus L. rhizomes. J App Pharm Sci. 5(12):096–100. doi: 10.7324/JAPS.2015.501216.
  • Noreen H, Semmar N, Farman M, McCullag JSO. 2017. Measurement of total phenolic content and antioxidant activity of aerial parts of medicinal plant Coronopus didymus. Asian Pac J Trop Biomed. 10(8):792–801. doi: 10.1016/j.apjtm.2017.07.024.
  • Ochieng Nyalo P, Isanda Omwenga G, Piero Ngugi M. 2022. GC-MS analysis, antibacterial and antioxidant potential of ethyl acetate leaf extract of Senna singueana (Delile) grown in Kenya. eCAM. 2022:5436476. doi: 10.1155/2022/5436476.
  • Orçan İ, Bülbül AS, Kara Y. 2023. Alyssum filiforme bitkisinin antimikrobiyal, antibiyofilm, antioksidan aktivitesinin ve fenolik profilinin belirlenmesi. J Adv Res Nat Appl Sci. 9(1):48–55. doi: 10.28979/jarnas.1085431.
  • Özay C, Mammadov R. 2016. Assessment of some biological activities of Alyssum l. known as madwort. Acta Pol Pharm. 73(5):1213–1220.
  • Pan Y, Wang K, Huang S, Wang H, Mu X, He C, Ji X, Zhang J, Huang F. 2008. Antioxidant activity of microwave-assisted extract of longan (Dimocarpus Longan Lour.) peel. Food Chem. 106(3):1264–1270. doi: 10.1016/j.foodchem.2007.07.033.
  • Pasqualini V, Robles C, Garzino S, Greff S, Bousquet-Melou A, Bonin G. 2003. Phenolic compounds content in Pinus halepensis Mill. needles: a bioindicator of air pollution. Chemosphere. 52(1):239–248. doi: 10.1016/S0045-6535(03)00268-6.
  • Pathak MP, Pathak K, Saikia R, Gogoi U, Ahmad MZ, Patowary P, Das A. 2022. Immunomodulatory effect of mushrooms and their bioactive compounds in cancer: a comprehensive review. Biomed Pharmacother. 149:112901. doi: 10.1016/j.biopha.2022.112901.
  • Pollio A, Zarrelli A, Romanucci V, Di Mauro A, Barra F, Pinto G, Crescenzi E, Roscetto E, Palumbo G. 2016. Polyphenolic profile and targeted bioactivity of methanolic extracts from mediterranean ethnomedicinal plants on human cancer cell lines. Molecules. 21(4):395. doi: 10.3390/molecules21040395.
  • Roy A, Khan A, Ahmad İ, Alghamdi S, Rajab BS, Babalghith AO, Alshahrani MY, Islam S, Islam M. 2022. Flavonoids a bioactive compound from medicinal plants and its therapeutic applications. Biomed Res Int. 2022:5445291. doi: 10.1155/2022/5445291.
  • Sanni DM, Omotoyinbo OV. 2016. GC/MS Analysis of Pteleopsis suberosa stem bark methanol-chloroform extract. J Plant Sci. 4(3):37–40.
  • Şener LT, Albeniz G, Dinç B, Albeniz I. 2017. iCELLigence Real-Time cell analysis system for examining the cytotoxicity of drugs to cancer cell lines. Exp Ther Med. 14:1866–1870.
  • Shimer HW. 1943. Origin and significance of plant names. Hingham (MA): South Shore Nature Club.
  • Souri E, Amin G, Farsam H, Barazandeh Tehrani M. 2008. Screening of antioxidant activity and phenolic content of 24 medicinal plant extracts. DARU J Pharm Sci. 16:83–87.
  • Sowa P, Marcinčáková D, Miłek M, Sidor E, Legáth J, Dżugan M. 2020. Analysis of cytotoxicity of selected Asteraceae plant extracts in real time, their antioxidant properties and polyphenolic profile. Molecules. 25(23):5517. doi: 10.3390/molecules25235517.
  • Stefanowicz-Hajduk J, Renata Ochocka J. 2020. Real-time cell analysis system in cytotoxicity applications: usefulness and comparison with tetrazolium salt assays. Toxicol Rep. 7:335–344. doi: 10.1016/j.toxrep.2020.02.002.
  • To’bungan N. 2023. Antiproliferative and apoptotic effect of Knobweed (Hyptis capitata) root methanol extract on WiDr colorectal cancer cells. Plant Sci Today. 10(3):393–398.
  • To’bungan N, Nugroho Jati W, Zahida F. 2022. Acute toxicity and anticancer potential of knobweed (Hyptis capitata) ethanolic leaf extract and fraction. Plant Sci Today. 9(4):955–962.
  • Velumani A, Senthamil Selvi V. 2019. Gas chromatography and mass spectroscopic analysis of bioactive constituents in Mangifera indica leaves extract. J Adv Sci Re. 10(4):96–100.
  • Yamuna P, Abirami P, Vijayashalini P, Sharmila M. 2017. GC/MS analysis of bioactive compounds in the entire plant parts of ethanolic extract of Gomphrena decumbens Jacq. J Mech Phys Solids. 5(3):31–37.
  • Yan G, Du Q, Wei X, Miozzi J, Kang C, Wang J, Han X, Pan J, Xie H, Chen J, et al. 2018. Application of real-time cell electronic analysis system in modern pharmaceutical evaluation and analysis. Molecules. 23(12):3280. doi: 10.3390/molecules23123280.
  • Yang MH, Ha IJ, Ahn J, Kim C-K, Lee M, Ahn KS. 2023. Potential function of loliolide as a novel blocker of epithelial-mesenchymal transition in colorectal and breast cancer cells. Cell Signal. 105:110610. doi: 10.1016/j.cellsig.2023.110610.
  • Yang X, Kang M-C, Lee K-W, Kang S-M, Lee W-W, Jeon Y-J. 2011. Antioxidant activity and cell protective effect of loliolide isolated from Sargassum ringgoldianum subsp. coreanum. Algae. 26(2):201–208. doi: 10.4490/algae.2011.26.2.201.
  • Yu F-R, Lian X-Z, Guo H-Y, McGuire PM, Li R-D, Wang R, Yu F-H. 2005. Isolation and characterization of methyl esters and derivatives from Euphorbia kansui (Euphorbiaceae) and their inhibitory effects on the human SGC-7901 cells. J Pharm Sci. 278(3):528–535.
  • Yuenyong J, Pokkanta P, Phuangsaijai N, Kittiwachana S, Mahatheeranont S, Sookwong P. 2021. GC/MS and HPLC-DAD analysis of fatty acid profile and functional phytochemicals in fifty cold-pressed plant oils in Thailand. Heliyon. 7(2):e06304. doi: 10.1016/j.heliyon.2021.e06304.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.