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Original Articles

Chimeric protein of CD8a extracellular domain and CD4 transmembrane and cytoplasmic domain binds more efficiently to p56lck than CD8a

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Pages 331-336 | Received 02 Jul 1999, Accepted 30 Jul 1999, Published online: 22 Nov 2010

References

  • Bachmann , MF , Gallimore , A , Linkert , S , Cerundoto , V , Lanzavecchia , A , Kopf , M and Viola , A . 1999 . Developmental regulation of Ick targeting to the CDS coreceptor controls signaling in naive and memory T cells . J Exp Med , 189 : 1521 – 1530 .
  • Sasson , MA , Bommhardt , U , Mee , PJ , Tybulewicz , VL and Zamoyska , R . 1998 . Molecular requirements for lineage commitment in the thyrnus antibody mediated receptor engagements reveal a central role for Ick in lineage decisions . Immunol Rev , 165 : 181 – 194 .
  • Blue , ML , Craig , KA , Anderson , P , Branton , KR Jr and Schlossman , SF . 1988 . Evidence for specific association between class J major histocompatibility antigens and the CD8 molecules of human suppressor/cytotoxic cells . Cell , 54 : 413 – 421 .
  • Chan , S , Correia‐Neves , M , Benoist , C and Mathis , D . 1998 . CD4/CD8 lineage commitment: matching fate with competence . Immunol Rev , 165 : 195 – 207 .
  • Coligan , JE , Kruisbeek , AM , Margulies , DH , Shevach , EM and Strober , W . 1991 . Current Protocols in Immunology , 5:3:1 – 5:3:3 . New York : John Wiley & Sons, Inc .
  • Crump , AL , Grusby , MJ , Glimcher , LH and Cantor , H . 1993 . Thymocyte development in major histocompatibility complex‐deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages . Proc Natl Acad Sci USA , 90 : 10739 – 10743 .
  • Di Nocera , PP and EDawid , IB . 1983 . Transient expression of genes introduced into cultured cells of Drosophila . Proc Natl Acad Sci USA , 80 : 7095 – 7098 .
  • Fung‐Leung , WP , Schilham , MW , Rahemtulla , A , Kundig , TM , Vollenweider , M , Potter , J , van Ewijk , W and Mak , TW . 1991 . CDS is needed for development of cytotoxic T cells but not helper T cells . Cell , 65 : 443 – 449 .
  • Groves , T , Smiley , P , Cooke , MP , Forbush , K , Perlmutter , RM and Guidos , CJ . 1996 . Fyn can partially substitute for Ick in T lymphocyte development . Immunity , 5 : 417 – 428 .
  • Huse , M , Eck , MJ and Harrison , SC . 1998 . A Zn2+ ton links the cytoplasmic tail of CD4 and the N‐terminal region of Ick . J Biol Chem , 273 : 18729 – 18733 .
  • Irie , HY , Ravichandran , KS and Burakoff , SJ . 1995 . CD8 beta chain influences CD8 alpha chain‐associated Ick kinase activity . J Exp Med , 181 : 1267 – 1273 .
  • Irie , HY , Mong , MS , Llano , A , Crooks , ME , Liftman , DR , Burakoff , SJ and Robey , E . 1998 . The cytoplasmic domain of CDS beta regulates Ick kinase activation and CD8 T cell development . J Immunol , 161 : 183 – 191 .
  • Itano , A , Salmon , P , Kioussis , D , Tolaini , M , Corbella , P and Robey , E . 1996 . The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells . J Exp Med , 183 : 731 – 741 .
  • Johnson‐Tardieu , JM , Walworth , EW , Cornelius , JG , Ye , X , Schuster , SM and Peck , AB . 1996 . Autoimmune diabetes‐prone NOD mice express the Lyt2 alpha (Lyt2.1) and Lyt3 alpha (Lyt3.1) alleles of CDS . Immunogenetics , 43 : 6 – 12 .
  • Killeen , N and Littman , DR . 1993 . Helper T cell development in the absence of CD4‐p56lck association . Nature , 364 : 729 – 732 .
  • Killeen , N , Sawada , S and Littman , DR . 1993 . Regulated expression of human CD4 rescues helper T ceil development in mice lacking expression of endogenous CD4 . EMBO J , 12 : 1547 – 1553 .
  • Killeen , N , Irving , BA , Pippig , S and Zingler , K . 1998 . Signaling checkpoints during the development of T lymphocytes . Curr Opin Immunol , 10 : 360 – 367 .
  • Levin , SD , Anderson , SJ , Forbush , KA and Perlmutter , RM . 1993 . A dominant‐negative transgene defines a role for p56lck in thymopoiesis . EMBO J , 12 : 1671 – 1680 .
  • Lin , RS , Rodriguez , C , Veillette , A and Lodish , HF . 1998 . Zinc is essential for binding of p56lck to CD4 and CDSa . J Biol Chem , 273 : 32878 – 32882 .
  • Lucas , B , Vasseur , F and Penit , C . 1995 . Stochastic coreceptor shut‐off is restricted to the CD4 lineage maturation pathway . J Exp Med , 181 : 1623 – 1633 .
  • Luescher , IF , Vivier , E , Layer , A , Mahiou , J , Godeau , F , Malissen , B and Romero , P . 1995 . CD8 modulation of T‐cell antigen receptor‐ligand interactions on living cytotoxic T lymphocytes . Nature , 373 : 353 – 356 .
  • Matechak , EO , Killeen , N , Hedrick , SM and Fowlkes , BJ . 1996 . MHC class Il‐specific T cells can develop in the CDS lineage when CD4 is absent . Immunity , 4 : 337 – 347 .
  • Micell , MC , von Hoegen , P and Parnes , JR . 1991 . Adhesion versus coreceptor function of CD4 and CD8: role of the cytoplasmic tail in coreceptor activity . Proc Natl Acad Sci USA , 88 : 2623 – 2627 .
  • Molina , TJ , Kishihara , K , Siderovski , DP , van Ewijk , W , Naren‐dran , A , Timms , E , Wakeham , A , Paige , CJ , Hartmann , KU , Veillette , A , Davidson , D and Mak , TW . 1992 . Profound block in thymocyte development in mice lacking p56lck . Nature , 357 : 161 – 164 .
  • Muller , KP and Kyewski , BA . 1995 . Intrathymic T cell receptor (TcR) targeting in mice lacking CD4 or major histocompatibility complex (MHC) class II: rescue of CD4 T cell lineage without co‐engagement of TCR/CD4 by MHC class II . Eur J Immunol , 25 : 896 – 902 .
  • Nicolai , SC , van Oers Lowin‐Kropf , B , Finlay , D , Connolly , K and Weiss , A . 1996 . abT cell development is abolished in mice lacking both Ick and Fyn protein tyrosine kinases . Immunity , 5 : 429 – 436 .
  • Parnes , JR and Seong , RH . 1994 . CD4 and CDS in T cell lineage commitment: alterations induced by expression of a CD8/CD4 chimeric transgene . Semin Immunol , 6 : 221 – 229 .
  • Paterson , RK , Burkly , LC , Kurahara , DK , Dunlap , A , Flavell , RA and Finkel , TH . 1994 . Thymic development in human CD4 transgenic mice. Positive selection occurs after commitment to the CD8 lineage . J Immunol , 153 : 3491 – 3503 .
  • Ravichandran , KS and Burakoff , SJ . 1994 . Evidence for differential intracellular signaling via CD4 and CDS molecules . J Exp Med , 179 : 727 – 732 .
  • Saito , T and Watanabe , N . 1998 . Positive and negative thymocyte selection . Crit Rev Immunol , 18 : 359 – 370 .
  • Seavitt , JR , White , LS , Murphy , KM , Loh , DY , Perlmutter , RM and Thomas , ML . 1999 . Expression of the p56(Lck) Y505F mutation in CD45‐deficient mice rescues thymocyte development . Mol Cell Biol , 19 : 4200 – 4208 .
  • Seong , RH , Chamberlain , JW and Parnes , JR . 1992 . Signal for T‐cell differentiation to a CD4 cell lineage is delivered by CD4 trans membrane region and/or cytoplasmic tail . Nature , 356 : 718 – 720 .
  • Seong , RH and Parnes , JR . 1992 . Alteration of T cell lineage commitment by expression of a hybrid CD8/CD4 transgene . Adv Exp Med Biol , 323 : 79 – 87 .
  • Shaw , AS , Amrein , KE , Hammond , C , Stern , DF , Sefton , BM and Rose , JK . 1989 . The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino‐terrninal domain . Cell , 59 : 627 – 636 .
  • Smith , DH , Lee , N and Lacy , E . 1996 . Thymocyte cell fate alteration by high levels of CD8a is independent of CDS‐ Ick association . J Immunol , 157 : 1087 – 1095 .
  • Stone , JD , Conroy , LA , Byth , KF , Hederer , RA , Howlett , S , Takemoto , Y , Holmes , N and Alexander , DR . 1997 . Aberrant TCR‐mediated signaling in CD45‐null thymocytes involves dysfunctional regulation of Ick, Fyn, TCR‐zeta, and ZAP‐70 . J Immunol , 158 : 5773 – 5782 .
  • Straus , DB and Weiss , A . 1993 . Genetic evidence for the involvement of the Ick tyrosine kinase in signal transduction through the T cell antigen receptor . Cell , 74 : 633 – 643 .
  • Turner , JM , Brodsky , MH , Irving , BA , Levin , SD , Perlmutter , RM and Littman , DR . 1990 . Interaction of the unique N‐terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs . Celt , 60 : 755 – 765 .
  • van Oers , NS , Killeen , N and Weiss , A . 1996 . Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP‐70 in murine thymocytes . J Exp Med , 183 : 1053 – 1062 .
  • Veillette , A , Bookman , MA , Horak , EM and Bolen , JB . 1988 . The CD4 and CDS T cell surface antigens are associated with the internal membrane tyrosine‐protein kinase p56lck . Cell , 55 : 301 – 308 .
  • Veillette , A , Sleckman , BP , Ratnofsky , S , Bolen , JB and Burakoff , SJ . 1990 . The cytoplasmic domain of CD4 is required for stable association with the lymphocyte‐specific tyrosine kinase p56lck . Eur J Immunol , 20 : 1397 – 1400 .
  • Wallace , VA , Kawai , K , Levelt , CN , Kishihara , K , Molina , T , Timms , E , Pircher , H , Penninger , J , Ohashi , PS and Eichmann , K . 1995 . T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR beta locus is incomplete but thymocyte development is not restored by TcR beta or TcR alpha beta transgenes . Eur J Immunol , 25 : 1312 – 1318 .
  • To whom correspondence should be addressed. Tel: 82–2–890–7567, Fax: 82–2–879–2809 E‐mail: [email protected]

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