Advanced search
Publication Cover
Biotechnology & Biotechnological Equipment Volume 29, 2015 - Issue 1
Submit an article Journal homepage
1,035
Views
12
CrossRef citations to date
0
Altmetric
Article; Pharmaceutical Biotechnology

Biological evaluation of synthesized allicin and its transformation products obtained by microwaves in methanol: antioxidant activity and effect on cell growth

Dušica P. IlićDepartment of Chemistry and Chemical Technology, Faculty of Technology, University of Niš, Leskovac, SerbiaView further author information
,
Sanja StojanovićDepartment for Cell and Tissue Engineering, Institute of Biology and Human Genetics, Faculty of Medicine, University of Niš, Niš, SerbiaView further author information
,
Stevo NajmanDepartment for Cell and Tissue Engineering, Institute of Biology and Human Genetics, Faculty of Medicine, University of Niš, Niš, SerbiaCorrespondence[email protected]
View further author information
,
Vesna D. NikolićDepartment of Chemistry and Chemical Technology, Faculty of Technology, University of Niš, Leskovac, SerbiaView further author information
,
Ljiljana P. StanojevićDepartment of Chemistry and Chemical Technology, Faculty of Technology, University of Niš, Leskovac, SerbiaView further author information
,
Ana TačićDepartment of Chemistry and Chemical Technology, Faculty of Technology, University of Niš, Leskovac, SerbiaView further author information
&
Ljubiša B. NikolićDepartment of Chemistry and Chemical Technology, Faculty of Technology, University of Niš, Leskovac, SerbiaView further author information
 show all
Pages 189-194 | Received 01 May 2014, Accepted 14 Jul 2014, Published online: 08 Jan 2015

References

  • Ilic DP, Nikolić VD, Stankovic MZ, Nikolic LB, Stanojević LP, Mladenovic-Ranisavljevic I, Smelcerovic A. Transformation of synthetic allicin: the influence of ultrasound, microwaves, different solvents and temperatures, and the products isolation. Scientific World J. 2012;2012:1–7.
  • Lawson LD, Wood SG, Hughers BG. HPLC Analysis of allicin and other thiosulfinates in garlic clove homogenates. Planta Medica. 1991;57:263–270.
  • Lee J, Gupta S, Huang JS, Jayathilaka LP, Lee BS. HPLC-MTT assay: anti-cancer activity of aqueous garlic extract is from allicin. Anal Biochem. 2013;436(2):187–189.
  • Nikolić V, Stankovic M, Kapor A, Nikolić L, Cvetkovic D, Stamenković J. Allylthiosulfinate: beta-cyclodextrin inclusion complex: preparation, characterization and microbiological activity. Pharmazie. 2004;59(11):845–848.
  • Rabinkov A, Miron T, Mirelman D, Wilchek M, Glozman S, Yavin E, Weiner L. Allylmercaptogluthatione: the reaction product of allicin with glutathione possesses SH-modifying and antioxidant properties. Biochimica Biophysica Acta. 2000;1499:144–153.
  • Ilic DP, Nikolic VD, Nikolic LB, Stankovic MZ, Stanojevic LP. Thermal degradation, antioxidant and antimicrobial activity of the synthesized allicin and allicin incorporated in gel. Chem Ind. 2010;6:85–93.
  • Gao Y, Liu YQ, Cao WK, Chen X, Wan YY, Heng C, Xu LJ. Effects of allicin on invasion and metastasis of colon cancer LoVo cell line in vitro. Zhonghua Yi Xue Za Zhi. 2009;89:1382–1386.
  • Ilic DP. Transformation products of allyl-thiosulfinate, pharmacological activity and preparation of pharmaceutical formulation [ dissertation]. Serbia: University of Niš; 2012.
  • Arroio A, Honório MK, Homem-de-Mello P, Weber CK, da Silva ABF. A density functional theory study on the role of electronic properties in the antioxidant activity of the ajoene molecule. Internet Electron J Mol Des. 2004;3:308–314.
  • Wu X, Kassie F, Mersch-Sundermann V. Induction of apoptosis in tumor cells by naturally occurring sulfur-containing compounds. Mutation Res Rev Mutation Res. 2005;589(2):81–102.
  • Kuete V, Krusche B, Youns M, Voukeng I, Fankam AG, Tankeo S, Lacmata S, Efferth T. Cytotoxicity of some Cameroonian spices and selected medicinal plant extracts. J Ethnopharmaco. 2011;134:803–812.
  • Hussain A, Harish G, Prabhu SA, Mohsin J, Khan MA, Rizvi TA, Sharma C. Inhibitory effect of genistein on the invasive potential of human cervical cancer cells via modulation of matrix metalloproteinase-9 and tissue inhibitiors of matrix metalloproteinase-1 expression. Cancer Epidemiol. 2012;36:e387–e393.
  • Noysang C, Mahringer A, Zeino M, Saeed M, Luanratana O, Fricker G, Bauer R, Efferth T. Cytotoxicity and inhibition of P-glycoprotein by selected medicinal plants from Thailand. J Ethnopharmacol. 2014;155:633–641.
  • Stanojevic LP, Stankovic MZ, Nikolic VD, Nikolic LB. Anti-oxidative and antimicrobial activities of Hieracium pilosella L. extracts. J Serbian Chem Soc. 2008;73:531–540.
  • Savić V, Ilić D, Nikolić V, Nikolić L, Stanković M, Stanojevic L, Tasić-Kostov M. Topical preparations of allicin and transformers: antimicrobial and anti-irritating effects. Poster session presented at: The Fifth Congress of Pharmacy of Macedonia with International Participation; 2011 Sep 21–25; Ohrid.
  • Ilić D, Nikolić V, Ćirić A, Soković M, Stanojković T, Kundaković T, Stanković M, Nikolić L. Cytotoxicity and antimicrobial activity of allicin and its transformation products. J Med Plants Res. 2012;6(1):59–65.
  • Yung-Lin C, Chi-Tang H, Jing-Gung C, Rajasekaran R, Yi-Chen L, Lee-Yan S. Allicin induces anti-human liver cancer cells through the p53 gene modulating apoptosis and autophagy. J Agric Food Chem. 2013;61:9839–9848.
  • Hirsch K, Danilenko M, Giat J, Miron T, Rabinkov A, Wilchek M. Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation. Nutr Cancer. 2000;38:245–254.
  • Lawson LD. Garlic: a review of its medicinal effects and indicated active compounds. In: Lawson LD, Bauer R, editors. Phytomedicines of Europe: chemistry and biological activity. ACS Symposium Series No 691. Washington, DC: American Chemical Society; 1998.
  • Prager-Khoutorsky M, Goncharov I, Rabinkov A, Mirelman D, Geiger B, Bershadsky DA. Allicin inhibits cell polarization, migration and division via its direct effect on microtubules. Cell Motil Cytoskeleton. 2007;64:321–337.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.