Exploration of collagenase, cyclooxigenases, angiogenesis and free radical processes as the putative pharmacological targets of Arum maculatum L.

References

• Cragg GM, Newman DJ. Natural products: a continuing source of novel drug leads. Biochim Biophys Acta. 2013;1830(6):3670–3695.
   PubMed Web of Science ®Google Scholar
• Cragg GM, Newman DJ. Antineoplastic agents from natural sources: achievements and future directions. Expert Opin Investig Drugs. 2000;9(12):2783–2797.
   PubMed Web of Science ®Google Scholar
• Cragg GM, Newman DJ. Discovery and development of antineoplastic agents from natural sources. Cancer Invest. 1999;17(2):153–163.
   PubMed Web of Science ®Google Scholar
• Cragg GM, Boyd MR, Cardellina JH, 2nd, et al. Ethnobotany and drug discovery: the experience of the US National Cancer Institute. Ciba Found Symp. 1994;185:178–190, discussion 90–96.
   PubMedGoogle Scholar
• Heinrich M, Barnes J, Gibbons S, et al. Fundamentals of pharmacognosy and phytotherapy. 2nd ed. Edinburgh (UK): Elsevier; 2012. Chapter 1, Importance of plants in modern pharmacy and medicine; p. 3–9.
   Google Scholar
• Evans WC, Trease GE, editors. The plant and animal kingdoms as sources of drugs. In: Evans WC, Trease GE, editors. Trease and Evans’ pharmacognosy. 15th ed. New York (NY): WB Saunders; 2002. p. 13–54.
   Google Scholar
• Basmadjian C, Zhao Q, Bentouhami E, et al. Cancer wars: natural products strike back. Front Chem. 2014;2:20.
   PubMed Web of Science ®Google Scholar
• Zhuang C, Zhang W, Sheng C, et al. Chalcone: a privileged structure in medicinal chemistry. Chem Rev. 2017;117(12):7762–7810.
   PubMed Web of Science ®Google Scholar
• Lichota A, Gwozdzinski L, Gwozdzinski K. Therapeutic potential of natural compounds in inflammation and chronic venous insufficiency. Eur J Med Chem. 2019;176:68–91.
   PubMed Web of Science ®Google Scholar
• Madoff RD, Clinical Practice Committee, American Gastroenterological Association, Fleshman JW. American gastroenterological association technical review on the diagnosis and treatment of hemorrhoids. Gastroenterology 2004;126(5):1463–1473.
   PubMed Web of Science ®Google Scholar
• Dozois EJ, Pemberton JH. Chapter Sixty-Six – Hemorrhoids and other anorectal disorders. In: Wolfe MM, Davis GL, Farraye FA, Giannella RA, Malagelada J-R, Steer ML, editors. Therapy of digestive disorders. 2nd ed. Edinburgh (UK): W.B. Saunders; 2006. p. 945–958.
   Google Scholar
• Moult H-L, Aubert M, De Parades V. Classical treatment of hemorrhoids. J Visceral Surg. 2015;152(2):S3–S9.
   PubMed Web of Science ®Google Scholar
• Erbay MŞ, Sarı A. Plants used in traditional treatment against hemorrhoids in Turkey. Marmara Pharm J. 2018;22(2):110–132.
   Google Scholar
• Dehdari S, Hajimehdipoor H, Esmaeili S, et al. Traditional and modern aspects of hemorrhoid treatment in Iran: a review. J Integr Med. 2018;16(2):90–98.
   PubMed Web of Science ®Google Scholar
• Buckshee K, Takkar D, Aggarwal N. Micronized flavonoid therapy in internal hemorrhoids of pregnancy. Int J Gynaecol Obstet. 1997;57(2):145–151.
   PubMed Web of Science ®Google Scholar
• Ho YH, Tan M, Seow-Choen F. Micronized purified flavonidic fraction compared favorably with rubber band ligation and fiber alone in the management of bleeding hemorrhoids: randomized controlled trial. Dis Colon Rectum. 2000;43(1):66–69.
   PubMed Web of Science ®Google Scholar
• Mahboubi M. Effectiveness of Myrtus communis in the treatment of hemorrhoids. J Integr Med. 2017;15(5):351–358.
   PubMed Web of Science ®Google Scholar
• Kochmarov V, Kozuharova E, Naychov Z, et al. Ethnobotany and ethnopharmacology of Arum maculatum L. (Araceae) in Bulgaria with an emphasis on its effect against haemorrhoids. Int J Pharm Chem Biol Sci. 2015;5(2):394–402.
   Google Scholar
• Leclerc H. [Wild arum (Arum maculatum L.); its use as food]. Presse Med. 1952;60(71):1514.
   PubMed Web of Science ®Google Scholar
• Kozuharova E, Kochmarov V, Semerdjieva I, et al. Potential of wild populations resources of Arum maculatum L. (Araceae) in Bulgaria – a prospective medicinal plant. C R Acad Bulgare Sci. 2018;71(2):193–200.
   Google Scholar
• Zisis S, Giannakou K, Lavranos G, et al. Alternative herbal medicine for hemorrhoids, Effect of Arum maculatum on the quality of life of patients: a randomized controlled trial. J Appl Pharm Sci. 2019;9:40–45.
   Google Scholar
• Kozuharova E, Kochmarov V, Kachaunova E, et al. Distribution of Arum (Araceae) in Bulgaria. Flora Medit. 2014;24:51–62.
   Google Scholar
• Re R, Pellegrini N, Proteggente A, et al. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biol Med. 1999;26(9-10):1231–1237.
   PubMed Web of Science ®Google Scholar
• Goupy P, Dufour C, Loonis M, et al. Quantitative kinetic analysis of hydrogen transfer reactions from dietary polyphenols to the DPPH radical. J Agric Food Chem. 2003;51(3):615–622.
   PubMed Web of Science ®Google Scholar
• Klink C, Binnebosel M, Kammer D, et al. Haemorrhoids are related to changes of cell function in mucosa and submucosa. Int J Colorectal Dis. 2009;24(12):1389–1394.
   PubMed Web of Science ®Google Scholar
• Wang C, Lu H, Luo C, et al. miR-412-5p targets Xpo1 to regulate angiogenesis in hemorrhoid tissue. Gene 2019;705:167–176.
   PubMed Web of Science ®Google Scholar
• Han W, Wang ZJ, Zhao B, et al. [Pathologic change of elastic fibers with difference of microvessel density and expression of angiogenesis-related proteins in internal hemorrhoid tissues]. Zhonghua Wei Chang Wai Ke Za Zhi. 2005;8(1):56–59.
   PubMedGoogle Scholar
• Diaz-Flores L, Gutierrez R, Gonzalez-Gomez M, et al. Segmentation of dilated hemorrhoidal veins in hemorrhoidal disease. Cells Tissues Organs 2018;205(2):120–128.
   PubMed Web of Science ®Google Scholar
• Serra R, Gallelli L, Grande R, et al. Hemorrhoids and matrix metalloproteinases: a multicenter study on the predictive role of biomarkers. Surgery 2016;159(2):487–494.
   PubMed Web of Science ®Google Scholar
• Mladenov I, Bulanov I, Stamenova M, et al. [The composition and structure of isolectins from Arum maculatum]. Eksp Med Morfol. 1990;29(1):36–39.
   PubMedGoogle Scholar
• Alencar VB, Alencar NM, Assreuy AM, et al. Pro-inflammatory effect of Arum maculatum lectin and role of resident cells. Int J Biochem Cell Biol. 2005;37(9):1805–1814.
   PubMed Web of Science ®Google Scholar
• Koleva M, Achtardjieff C. [A glucomannan in the tubers of arum maculatum l]. Pharmazie 1975;30(2):111–113.
   PubMed Web of Science ®Google Scholar
• Sapsrithong T, Kaewprem W, Tongumpai S, et al. Cissus quadrangularis ethanol extract upregulates superoxide dismutase, glutathione peroxidase and endothelial nitric oxide synthase expression in hydrogen peroxide-injured human ECV304 cells. J Ethnopharmacol. 2012;143(2):664–672.
   PubMed Web of Science ®Google Scholar
• Kucukkurt I, Ince S, Keles H, et al. Beneficial effects of Aesculus hippocastanum L. seed extract on the body’s own antioxidant defense system on subacute administration. J Ethnopharmacol. 2010;129(1):18–22.
   PubMed Web of Science ®Google Scholar
• Aggrawal K, Satija N, Dasgupta G, et al. Efficacy of a standardized herbal preparation (Roidosanal®) in the treatment of hemorrhoids: a randomized, controlled, open-label multicentre study. J Ayurveda Integr Med. 2014;5(2):117–124.
   PubMedGoogle Scholar
• Meshikhes AW. Efficacy of Daflon in the treatment of hemorrhoids. Saudi Med J. 2002;23(12):1496–1498.
   PubMed Web of Science ®Google Scholar