The antitumor activity of cannabidiol on lung cancer cell lines A549 and H1299: the role of apoptosis

References

• The American Cancer Society. Key statistics for lung cancer; 2021. Official statistics: USA. https://www.cancer.org/cancer/lung-cancer/about/key-statistics.html
   Google Scholar
• Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.
   PubMed Web of Science ®Google Scholar
• Terlizzi M, Colarusso C, Pinto A, et al. Drug resistance in non-small cell lung Cancer (NSCLC): Impact of genetic and non-genetic alterations on therapeutic regimen and responsiveness. Pharmacol Ther. 2019;202:140–148.
   PubMed Web of Science ®Google Scholar
• Schurman LD, Lu D, Kendall DA, et al. Molecular mechanism and cannabinoid pharmacology. Handb Exp Pharmacol. 2020;258:323–353.
   PubMedGoogle Scholar
• Pacher P, Kogan NM, Mechoulam R. Beyond THC and endocannabinoids. Annu Rev Pharmacol Toxicol. 2020;60:637–659.
   PubMed Web of Science ®Google Scholar
• Cooray R, Gupta V, Suphioglu C. Current aspects of the endocannabinoid system and targeted THC and CBD phytocannabinoids as potential therapeutics for Parkinson’s and Alzheimer’s diseases: a review. Mol Neurobiol. 2020;57:4878–4890.
   PubMed Web of Science ®Google Scholar
• Atalay S, Jarocka-Karpowicz I, Skrzydlewska E. Antioxidative and anti-inflammatory properties of cannabidiol. Antioxidants (Basel). 2019;9. doi:10.3390%2Fantiox9010021.
   PubMedGoogle Scholar
• Straiker A, Dvorakova M, Zimmowitch A, et al. Cannabidiol inhibits endocannabinoid signaling in autaptic hippocampal neurons. Mol Pharmacol. 2018;94:743–748.
   PubMed Web of Science ®Google Scholar
• Taylor L, Gidal B, Blakey G, et al. A phase I, randomized, double-blind, placebo-controlled, single ascending dose, multiple dose, and food effect trial of the safety, tolerability and pharmacokinetics of highly purified cannabidiol in healthy subjects. CNS Drugs. 2018;32:1053–1067.
   PubMed Web of Science ®Google Scholar
• Seltzer ES, Watters AK, MacKenzie D, Jr, et al. Cannabidiol (CBD) as a promising anti-cancer drug. Cancers (Basel). 2020;12:3203.
   PubMedGoogle Scholar
• Javid FA, Phillips RM, Afshinjavid S, et al. Cannabinoid pharmacology in cancer research: a new hope for cancer patients?Eur J Pharmacol. 2016;775:1–14.
   PubMed Web of Science ®Google Scholar
• Ligresti A, Moriello AS, Starowicz K, et al. Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. J Pharmacol Exp Ther. 2006;318:1375–1387.
   PubMed Web of Science ®Google Scholar
• Massi P, Vaccani A, Bianchessi S, et al. The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells. Cell Mol Life Sci. 2006;63:2057–2066.
   PubMed Web of Science ®Google Scholar
• McKallip RJ, Jia W, Schlomer J, et al. Cannabidiol-induced apoptosis in human leukemia cells: a novel role of cannabidiol in the regulation of p22phox and Nox4 expression. Mol Pharmacol. 2006;70:897–908.
   PubMed Web of Science ®Google Scholar
• Shrivastava A, Kuzontkoski PM, Groopman JE, et al. Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy. Mol Cancer Ther. 2011;10:1161–1172.
   PubMed Web of Science ®Google Scholar
• De Petrocellis L, Ligresti A, Schiano Moriello A, et al. Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms. Br J Pharmacol. 2013;168:79–102.
   PubMed Web of Science ®Google Scholar
• Ramer R, Merkord J, Rohde H, et al. Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1. Biochem Pharmacol. 2010;79:955–966.
   PubMed Web of Science ®Google Scholar
• Ramer R, Rohde A, Merkord J, et al. Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells. Pharm Res. 2010;27:2162–2174.
   PubMed Web of Science ®Google Scholar
• Ramer R, Bublitz K, Freimuth N, et al. Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. Faseb J. 2012;26:1535–1548.
   PubMed Web of Science ®Google Scholar
• McAllister SD, Christian RT, Horowitz MP, et al. Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells. Mol Cancer Ther. 2007;6:2921–2927.
   PubMed Web of Science ®Google Scholar
• Shim MK, Yoon, HY, Lee S, et al. Caspase-3/-7-specific metabolic precursor for bioorthogonal tracking of tumor apoptosis. Sci Rep. 2017;7:16635.
   PubMed Web of Science ®Google Scholar
• Kamenova-Nacheva M, Schröder M, Pasheva E, et al. Synthesis of ferrocenylmethylidene and arylidene substituted camphane based compounds as potential anticancer agents. New J Chem. 2017;41:9103–9112.
   Web of Science ®Google Scholar
• Ugrinova I, Monier K, Ivaldi C, et al. Inactivation of nucleolin leads to nucleolar disruption, cell cycle arrest and defects in centrosome duplication. Bmc Mol Biol. 2007;8:1–16.
   PubMed Web of Science ®Google Scholar
• Schroder M, Yusein-Myashkova S, Petrova M, et al. The effect of a ferrocene containing camphor sulfonamide DK-164 on breast cancer cell lines. Anticancer Agents Med Chem. 2019;19:1874–1886.
   PubMed Web of Science ®Google Scholar
• Agniswamy J, Fang B, Weber IT. Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis. Febs J. 2007;274:4752–4765.
   PubMed Web of Science ®Google Scholar
• Thermophisher Scientific. CellEvent™ caspase-3/7 green detection reagent product overview. Available from: https://www.thermofisher.com/order/catalog/product/C10423#/C10423.
   Google Scholar
• Yusein-Myashkova S, Stoykov I, Gospodinov A, et al. The repair capacity of lung cancer cell lines A549 and H1299 depends on HMGB1 expression level and the p53 status. J Biochem. 2016;160:37–47.
   PubMed Web of Science ®Google Scholar
• Sayan BS, Sayan AE, Knight RA, et al. p53 is cleaved by caspases generating fragments localizing to mitochondria. J Biol Chem. 2006;281:13566–13573.
   PubMed Web of Science ®Google Scholar
• Heyne K, Roemer K. Caspase-3 joins the p53 interactome. Cancer Biol Ther. 2011;11:762–764.
   PubMed Web of Science ®Google Scholar
• Yang C, Kaushal V, Haun RS, et al. Transcriptional activation of caspase-6 and -7 genes by cisplatin-induced p53 and its functional significance in cisplatin nephrotoxicity. Cell Death Differ. 2008;15:530–544.
   PubMed Web of Science ®Google Scholar