Publication Cover
Redox Report
Communications in Free Radical Research
Volume 21, 2016 - Issue 6
885
Views
14
CrossRef citations to date
0
Altmetric
Original articles

Redox status of the testes and sperm of rats following exposure to 2,5-hexanedione

, , , , &

References

  • Smith PA. Toxicology of organic solvents. In: Luttrell William E., Jederberg Warren W., Still Kenneth R., (eds.) Toxicology principles for the industrial hygienist. Virginia: AIHA; 2008. pp. 187–207.
  • Boekelheide K, Fleming SL, Allio T, Embree-Ku ME, Hall SJ, Johnson KJ, Kwon EJ, Patel SR, Rasoulpour RJ, Schoenfeld HA, Thompson S. 2,5-hexanedione-induced testicular injury. Ann Review Pharmacol Toxicol 2003;43:125–47. doi: 10.1146/annurev.pharmtox.43.100901.135930
  • Adedara IA, Ebokaiwe AP, Farombi EO. Tissues distribution of heavy metals and erythrocytes antioxidant status in rats exposed to Nigerian bonny light crude oil. Toxicol Ind Health 2013;29:162–8. doi: 10.1177/0748233711427049
  • American Conference of Governmental Industrial Hygienists (ACGIH). TLVs and BEIs: Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices. American Conference of Governmental Industrial Hygienists, Cincinnati, OH, 2001, pp. 1–185.
  • Prieto MJ, Marhuenda D, Roel J, Cardona A. Free and total 2,5-hexanedione in biological monitoring of workers exposed to n-hexane in the shoe industry. Toxicol Lett 2003;145:249–60. doi: 10.1016/S0378-4274(03)00302-3
  • Neghab M, Soleimani E, Rajaeefard A. Assessment of occupational exposure to n-hexane: a study in shoe making workshops. Res J Environ Toxicol 2011;5:293–300. doi: 10.3923/rjet.2011.293.300
  • Boekelheide K, Johnson KJ, Richburg JH. Sertoli cell toxicants. In: Griswold MD, Skinner MK, (eds.) Sertoli cell biology. San Diego, CA: Elsevier Inc.; 2005. pp. 345–82.
  • Moffit JS, Bryant BH, Hall SJ, Boekelheide K. Dose-dependent effects of sertoli cell toxicants 2,5-hexanedione, carbendazim, and mono-(2-ethylhexyl) phthalate in adult rat testis. Toxicol Pathol 2007;35:719–27. doi: 10.1080/01926230701481931
  • Yamasaki H, Sandrof MA, Boekelheide K . Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. I. Histopathological analysis reveals stage dependence of attenuated apoptosis. Toxicol Sci 2010;117:449–56. doi: 10.1093/toxsci/kfq203
  • Catlin NR, Huse SM, Boekelheide K. The Stage-specific testicular germ cell apoptotic response to low-dose X-irradiation and 2,5-hexanedione combined exposure. I: validation of the laser capture microdissection method for qRT-PCR array application. Toxicol Pathol 2014;42:1221–8. doi: 10.1177/0192623314526319
  • Adedara IA, Abolaji AO, Odion BE, Okwudi IJ, Omoloja AA, Farombi EO. Impairment of hepatic and renal functions by 2,5-hexanedione is accompanied by oxidative stress in rats. J Toxicol 2014;2014:239240. doi:10.1155/2014/239240.
  • Farombi EO, Abolaji AO, Adedara IA, Soladogun A, Salau V, Oguaka M. Oxidative stress and changes in antioxidative defence system in erythrocytes of female rats exposed to 2, 5-hexanedione. Arch Bas App Med 2014;2:29–33.
  • Abolaji AO, Adedara IA, Soladogun A, Salau V, Oguaka M, Farombi EO. Exposure to 2,5-hexanedione is accompanied by ovarian and uterine oxidative stress and disruption of endocrine balance in rats. Drug Chem Toxicol 2015;38:400–07. doi: 10.3109/01480545.2014.974265
  • Aitken RJ. Free radicals, lipid peroxidation and sperm function. Reprod Fertil Dev 1995;7:659–68. doi: 10.1071/RD9950659
  • Gil-Guzman E, Ollero M, Lopez MC, Sharma RK, Alvarez JG, Thomas AJ Jr, Agarwal A. Differential production of reactive oxygen species by subsets of human spermatozoa at different stages of maturation. Human Reprod 2001;16:1922–30. doi: 10.1093/humrep/16.9.1922
  • Adedara IA, Vaithinathan S, Jubendradass R, Mathur PP, Farombi EO. Kolaviron prevents carbendazim-induced steroidogenic dysfunction and apoptosis in testes of rats. Environ Toxicol Pharmacol 2013;35:444–53. doi: 10.1016/j.etap.2013.01.010
  • National Research Council. Guide for the care and use of laboratory animals. Washington: National Academies Press; 2011.
  • Public Health Service (PHS). Public Health Service Policy on Humane Care and Use of Laboratory Animals. US Department of Health and Human Services, Washington, DC. [PL 99–158. Health Research Extension Act, 1985]; 1996.
  • Bryant BH, Yamasaki H, Sandrof MA, Boekelheide K. Spermatid head retention as a marker of 2,5-hexanedione-induced testicular toxicity in the rat. Toxicol Pathol 2008;36:552–9. doi: 10.1177/0192623308317426
  • Prieto-Castelló MJ, Hernández-Viadel ML, Cardona A, Marhuenda D, Felipo V. Activation of soluble guanylate cyclase by nitric oxide is increased in lymphocytes from both rats chronically exposed to 2,5-hexanedione and workers chronically exposed to n-hexane. Toxicology 2007;229:73–8. doi: 10.1016/j.tox.2006.10.002
  • Zemjanis R. Collection and evaluation of semen. In: Zemjanis R., (ed.) Diagnostic and therapeutic technique in animal reproduction, 2nd edn. Baltimore, MA, USA: William and Wilkins Company, Waverly Press, Inc.; 1970. pp. 139–53.
  • World Health Organization. Laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 4th edn. New York: Cambridge University Press; 1999. 76:4–33.
  • Wells ME, Awa OA. New technique for assessing acrosomal characteristics of spermatozoa. J Dairy Sci 1970;53:227. doi: 10.3168/jds.S0022-0302(70)86184-7
  • Adedara IA, Farombi EO. Chemoprotection of ethylene glycol monoethyl ether-induced reproductive toxicity in male rats by kolaviron, isolated biflavonoid from Garcinia kola seed. Hum Exp Toxicol 2012;31:506–17. doi: 10.1177/0960327111424301
  • Misra HP, Fridovich I. The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 1972;247:3170–5.
  • Clairborne A. Catalase activity. In: Greewald AR, (ed.) Handbook of methods for oxygen radical research. Boca Raton, FL: CRC Press; 1995. pp. 237–42.
  • Habig WH, Pabst MJ, Jakoby WB. Glutathione-S-transferase. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974;249:7130–9.
  • Jollow DJ, Mitchell JR, Zampaglione N, Gillette JR. Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3,4 bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 1974;11:151–69. doi: 10.1159/000136485
  • Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973;179:588–90. doi: 10.1126/science.179.4073.588
  • Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with folin phenol reagent. J Biol Chem 1951;193:265–75.
  • Wolff SP. Ferrous ion oxidation in the presence of ferric ion indicator xylenol orange for measurement of hydroperoxides. Methods Enzymol 1994;233:182–9. doi: 10.1016/S0076-6879(94)33021-2
  • Farombi EO, Tahnteng JG, Agboola AO, Nwankwo JO, Emerole GO. Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron-a Garcinia kola seed extract. Food Chem Toxicol 2000;38:535–41. doi: 10.1016/S0278-6915(00)00039-9
  • Jiang YG, Peng T, Luo Y, Li MC, Lin YH. Resveratrol reestablishes spermatogenesis after testicular injury in rats caused by 2,5-hexanedione. Chin Med J (Engl) 2008;121:1204–9.
  • Aitken RJ, Roman SD. Antioxidant systems and oxidative stress in the testes. In: Cheng CY, (ed.) Molecular mechanisms in spermatogenesis. New York: Landes Bioscience and Springer Science + Business Media; 2008. pp. 154–71.
  • Pacheco SE, Anderson LM, Sandrof MA, Vantangoli MM, Hall SJ, Boekelheide K. Sperm mRNA transcripts are indicators of sub-chronic low dose testicular injury in the Fischer 344 rat. PLoS ONE 2012;7:e44280. doi: 10.1371/journal.pone.0044280
  • Uygur R, Aktas C, Caglar V, Uygur E, Erdogan H, Ozen OA. Protective effects of melatonin against arsenic-induced apoptosis and oxidative stress in rat testes. Toxicol Ind Health 2013; doi:10.1177/0748233713512891
  • Prabakaran D, Ashokkumar N. Protective effect of esculetin on hyperglycemia-mediated oxidative damage in the hepatic and renal tissues of experimental diabetic rats. Biochimie 2013;95:366–73. doi: 10.1016/j.biochi.2012.10.008
  • Adedara IA, Farombi EO. Influence of kolaviron and vitamin E on ethylene glycol monoethyl ether-induced haematotoxicity and renal apoptosis in rats. Cell Biochem Funct 2014;32:31–38. doi: 10.1002/cbf.2968
  • Dhanabalan S, Mathur PP. Low dose of 2,3,7,8 tetrachlorodibenzo-p-dioxin induces testicular oxidative stress in adult rats under the influence of corticosterone. Exp Toxicol Pathol 2009;61:415–23. doi: 10.1016/j.etp.2008.10.005
  • Tremellen K. Oxidative stress and male infertility-a clinical perspective. Human Reprod Update 2008;14:243–58. doi: 10.1093/humupd/dmn004
  • Chapin RE, Norton RM, Popp JA, Bus JS. The effects of 2,5-hexanedione on reproductive hormones and testicular enzyme activities in the F-344 rat. Toxicol Appl Pharmacol 1982;62:262–72. doi: 10.1016/0041-008X(82)90124-7
  • Chapin RE, Morgan KT, Bus JS. The morphogenesis of testicular degeneration induced in rats by orally administered 2,5-hexanedione. Exp Mol Pathol 1983;38:149–69. doi: 10.1016/0014-4800(83)90082-5

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.