Intravenous rutin in rat exacerbates isoprenaline-induced cardiotoxicity likely due to intracellular oxidative stress

References

• Bravo L. Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev 1998;56(11):317–33. doi: 10.1111/j.1753-4887.1998.tb01670.x
   PubMed Web of Science ®Google Scholar
• Toh JY, Tan VM, Lim PC, Lim ST, Chong MF. Flavonoids from fruit and vegetables: a focus on cardiovascular risk factors. Curr Atheroscler Rep 2013;15(12):368. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24091782. doi: 10.1007/s11883-013-0368-y
   PubMed Web of Science ®Google Scholar
• Mink PJ, Scrafford CG, Barraj LM, Harnack L, Hong CP, Nettleton JA, et al. Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am J Clin Nutr 2007;85(3):895–909.
   PubMed Web of Science ®Google Scholar
• Hooper L, Kroon PA, Rimm EB, Cohn JS, Harvey I, Le Cornu KA, et al. Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2008;88(1):38–50.
   PubMed Web of Science ®Google Scholar
• Mladenka P, Zatloukalova L, Filipsky T, Hrdina R. Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity. Free Radic Biol Med 2010;49(6):963–75. doi: 10.1016/j.freeradbiomed.2010.06.010
   PubMed Web of Science ®Google Scholar
• Mladenka P, Macakova K, Filipsky T, Zatloukalova L, Jahodar L, Bovicelli P, et al. In vitro analysis of iron chelating activity of flavonoids. J Inorg Biochem 2011;105(5):693–701. doi: 10.1016/j.jinorgbio.2011.02.003
   PubMed Web of Science ®Google Scholar
• Seyoum A, Asres K, El-Fiky FK. Structure–radical scavenging activity relationships of flavonoids. Phytochemistry 2006;67(18):2058–70. doi: 10.1016/j.phytochem.2006.07.002
   PubMed Web of Science ®Google Scholar
• Nagao A, Seki M, Kobayashi H. Inhibition of xanthine oxidase by flavonoids. Biosci Biotechnol Biochem 1999;63(10):1787–90. doi: 10.1271/bbb.63.1787
   PubMed Web of Science ®Google Scholar
• Mira L, Fernandez MT, Santos M, Rocha R, Florencio MH, Jennings KR. Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity. Free Radic Res 2002;36(11):1199–208. doi: 10.1080/1071576021000016463
   PubMed Web of Science ®Google Scholar
• El Haouari M, Rosado JA. Modulation of platelet function and signaling by flavonoids. Mini Rev Med Chem 2011;11(2):131–42. doi: 10.2174/138955711794519537
   PubMed Web of Science ®Google Scholar
• Riha M, Karlickova J, Filipsky T, Macakova K, Rocha L, Bovicelli P, et al. In vitro evaluation of copper-chelating properties of flavonoids. RSC Adv 2014;4(62):32628–38. doi: 10.1039/C4RA04575K
   Web of Science ®Google Scholar
• Macakova K, Mladenka P, Filipsky T, Riha M, Jahodar L, Trejtnar F, et al. Iron reduction potentiates hydroxyl radical formation only in flavonols. Food Chem 2012;135(4):2584–92. doi: 10.1016/j.foodchem.2012.06.107
   PubMed Web of Science ®Google Scholar
• Prochazkova D, Bousova I, Wilhelmova N. Antioxidant and prooxidant properties of flavonoids. Fitoterapia 2011;82(4):513–23. doi: 10.1016/j.fitote.2011.01.018
   PubMed Web of Science ®Google Scholar
• Cao G, Sofic E, Prior RL. Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. Free Radic Biol Med 1997;22(5):749–60. doi: 10.1016/S0891-5849(96)00351-6
   PubMed Web of Science ®Google Scholar
• Kloner RA. Natural and unnatural triggers of myocardial infarction. Prog Cardiovasc Dis 2006;48(4):285–300. doi: 10.1016/j.pcad.2005.07.001
   PubMed Web of Science ®Google Scholar
• Schömig A. Catecholamines in myocardial ischemia. Systemic and cardiac release. Circulation 1990;82(3 Suppl):II13–22.
   Google Scholar
• Chagoya de Sánchez V, Hernández-Muñoz R, López-Barrera F, Yañez L, Vidrio S, Suárez J, et al. Sequential changes of energy metabolism and mitochondrial function in myocardial infarction induced by isoproterenol in rats: a long-term and integrative study. Can J Physiol Pharmacol 1997;75(12):1300–11. doi: 10.1139/y97-154
   PubMed Web of Science ®Google Scholar
• Díaz-Muñoz M, Álvarez-Pérez MA, Yáñez L, Vidrio S, Martínez L, Rosas G, et al. Correlation between oxidative stress and alteration of intracellular calcium handling in isoproterenol-induced myocardial infarction. Mol Cell Biochem 2006;289(1–2):125–36. doi: 10.1007/s11010-006-9155-1
   PubMed Web of Science ®Google Scholar
• Mladěnka P, Hrdina R, Bobrovová Z, Semecký V, Vávrová J, Holecková M, et al. Cardiac biomarkers in a model of acute catecholamine cardiotoxicity. Hum Exp Toxicol 2009;28(10):631–40. doi: 10.1177/0960327109350665
   PubMed Web of Science ®Google Scholar
• Berenshtein E, Vaisman B, Goldberg-Langerman C, Kitrossky N, Konijn AM, Chevion M. Roles of ferritin and iron in ischemic preconditioning of the heart. Mol Cell Biochem 2002;234–235(1–2):283–92. doi: 10.1023/A:1015923202082
   PubMed Web of Science ®Google Scholar
• Rona G. Catecholamine cardiotoxicity. J Mol Cell Cardiol 1985;17(4):291–306. doi: 10.1016/S0022-2828(85)80130-9
   PubMed Web of Science ®Google Scholar
• Chappel CI, Rona G, Balazs T, Gaudry R. Severe myocardial necrosis produced by isoproterenol in the rat. Arch Int Pharmacodyn Ther 1959;122:123–8.
   PubMedGoogle Scholar
• Rona G, Chappel CI, Balazs T, Gaudry R. An infarct-like myocardial lesion and other toxic manifestations produced by isoproterenol in the rat. AMA Arch Pathol 1959;67(4):443–55.
   PubMedGoogle Scholar
• Bindoli A, Rigobello MP, Deeble DJ. Biochemical and toxicological properties of the oxidation products of catecholamines. Free Radic Biol Med 1992;13(4):391–405. doi: 10.1016/0891-5849(92)90182-G
   PubMed Web of Science ®Google Scholar
• Todd GL, Cullan GE, Cullan GM. Isoproterenol-induced myocardial necrosis and membrane permeability alterations in the isolated perfused rabbit heart. Exp Mol Pathol 1980;33(1):43–54. doi: 10.1016/0014-4800(80)90006-4
   PubMed Web of Science ®Google Scholar
• Karthick M, Stanely Mainzen Prince P. Preventive effect of rutin, a bioflavonoid, on lipid peroxides and antioxidants in isoproterenol-induced myocardial infarction in rats. J Pharm Pharmacol 2006;58(5):701–7. doi: 10.1211/jpp.58.5.0016
   PubMed Web of Science ®Google Scholar
• Stanely Mainzen Prince P, Karthick M. Preventive effect of rutin on lipids, lipoproteins, and ATPases in normal and isoproterenol-induced myocardial infarction in rats. J Biochem Mol Toxicol 2007;21(1):1–6. doi: 10.1002/jbt.20151
   PubMed Web of Science ®Google Scholar
• Stanely Mainzen Prince P, Priya S. Preventive effects of rutin on lysosomal enzymes in isoproterenol induced cardio toxic rats: biochemical, histological and in vitro evidences. Eur J Pharmacol 2010;649(1–3):229–35. doi: 10.1016/j.ejphar.2010.08.054
   PubMed Web of Science ®Google Scholar
• Punithavathi VR, Shanmugapriya K, Prince PS. Protective effects of rutin on mitochondrial damage in isoproterenol-induced cardiotoxic rats: an in vivo and in vitro study. Cardiovasc Toxicol 2010;10(3):181–9. doi: 10.1007/s12012-010-9077-8
   PubMed Web of Science ®Google Scholar
• Prince PS, Sathya B. Pretreatment with quercetin ameliorates lipids, lipoproteins and marker enzymes of lipid metabolism in isoproterenol treated cardiotoxic male Wistar rats. Eur J Pharmacol 2010;635(1–3):142–8. doi: 10.1016/j.ejphar.2010.02.019
   PubMed Web of Science ®Google Scholar
• Mladěnka P, Zatloukalová L, Šimůnek T, Bobrovová Z, Semecký V, Nachtigal P, et al. Direct administration of rutin does not protect against catecholamine cardiotoxicity. Toxicology 2009;255(1–2):25–32. doi: 10.1016/j.tox.2008.09.027
   PubMed Web of Science ®Google Scholar
• Riha M, Voprsalova M, Pilarova V, Semecky V, Holeckova M, Vavrova J, et al. Oral administration of quercetin is unable to protect against isoproterenol cardiotoxicity. Naunyn Schmiedebergs Arch Pharmacol 2014;387(9):823–35. doi: 10.1007/s00210-014-0995-z
   PubMed Web of Science ®Google Scholar
• Filipský T, Zatloukalová L, Mladěnka P, Hrdina R. Acute initial haemodynamic changes in a rat isoprenaline model of cardiotoxicity. Hum Exp Toxicol 2012;31(8):830–43. doi: 10.1177/0960327112438927
   PubMed Web of Science ®Google Scholar
• Zatloukalová L, Filipský T, Mladěnka P, Semecký V, Macaková K, Holecková M, et al. Dexrazoxane provided moderate protection in a catecholamine model of severe cardiotoxicity. Can J Physiol Pharmacol 2012;90(4):473–84. doi: 10.1139/y2012-009
   PubMed Web of Science ®Google Scholar
• Zhang Y, Huo M, Zhou J, Xie S. PKSolver: an add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel. Comput Methods Programs Biomed 2010;99(3):306–14. doi: 10.1016/j.cmpb.2010.01.007
   PubMed Web of Science ®Google Scholar
• Kimes BW, Brandt BL. Properties of a clonal muscle cell line from rat heart. Exp Cell Res 1976;98(2):367–81. doi: 10.1016/0014-4827(76)90447-X
   PubMed Web of Science ®Google Scholar
• Šimůnek T, Štěrba M, Popelová O, Kaiserová H, Adamcová M, Hroch M, et al. Anthracycline toxicity to cardiomyocytes or cancer cells is differently affected by iron chelation with salicylaldehyde isonicotinoyl hydrazone. Br J Pharmacol 2008;155(1):138–48. doi: 10.1038/bjp.2008.236
   PubMed Web of Science ®Google Scholar
• Chan EC, Pannangpetch P, Woodman OL. Relaxation to flavones and flavonols in rat isolated thoracic aorta: mechanism of action and structure–activity relationships. J Cardiovasc Pharmacol 2000;35(2):326–33. doi: 10.1097/00005344-200002000-00023
   PubMed Web of Science ®Google Scholar
• Jambhekar SS, Breen PJ. Basic pharmacokinetics. London: Pharmaceutical Press; 2009.
   Google Scholar
• Sharma S, Ali A, Ali J, Sahni JK, Baboota S. Rutin: therapeutic potential and recent advances in drug delivery. Expert Opin Investig Drugs 2013;22(8):1063–79. doi: 10.1517/13543784.2013.805744
   PubMed Web of Science ®Google Scholar
• Haenen GRMM, Paquay JBG, Korthouwer REM, Bast A. Peroxynitrite scavenging by flavonoids. Biochem Biophys Res Commun 1997;236(3):591–3. doi: 10.1006/bbrc.1997.7016
   PubMed Web of Science ®Google Scholar
• Moridani MY, Pourahmad J, Bui H, Siraki A, O'Brien PJ. Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers. Free Radic Biol Med 2003;34(2):243–53. doi: 10.1016/S0891-5849(02)01241-8
   PubMed Web of Science ®Google Scholar
• Firuzi O, Mladênka Pe, Petrucci R, Marrosu G, Saso L. Hypochlorite scavenging activity of flavonoids. J Pharm Pharmacol 2004;56(6):801–7. doi: 10.1211/0022357023556
   PubMed Web of Science ®Google Scholar
• Guardia T, Rotelli AE, Juarez AO, Pelzer LE. Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Farmaco 2001;56(9):683–7. doi: 10.1016/S0014-827X(01)01111-9
   PubMedGoogle Scholar
• Ugusman A, Zakaria Z, Chua KH, Megat Mohd Nordin NA, Abdullah Mahdy Z. Role of rutin on nitric oxide synthesis in human umbilical vein endothelial cells. ScientificWorldJournal 2014;2014:169370. Available from: http://www.hindawi.com/journals/tswj/2014/169370/ doi: 10.1155/2014/169370
   PubMed Web of Science ®Google Scholar
• Sheu J-R, Hsiao G, Chou P-H, Shen M-Y, Chou D-S. Mechanisms involved in the antiplatelet activity of rutin, a glycoside of the flavonol quercetin, in human platelets. J Agric Food Chem 2004;52(14):4414–8. doi: 10.1021/jf040059f
   PubMed Web of Science ®Google Scholar
• Labuda J, Bučková M, Heilerová Ľ, Šilhár S, Štepánek I. Evaluation of the redox properties and anti/pro-oxidant effects of selected flavonoids by means of a DNA-based electrochemical biosensor. Anal Bioanal Chem 2003;376(2):168–73.
   PubMed Web of Science ®Google Scholar
• Manach C, Morand C, Texier O, Favier ML, Agullo G, Demigne C, et al. Quercetin metabolites in plasma of rats fed diets containing rutin or quercetin. J Nutr 1995;125(7):1911–22.
   PubMed Web of Science ®Google Scholar
• Erlund I, Kosonen T, Alfthan G, Maenpaa J, Perttunen K, Kenraali J, et al. Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers. Eur J Clin Pharmacol 2000;56(8):545–53. doi: 10.1007/s002280000197
   PubMed Web of Science ®Google Scholar
• Rechner AR, Smith MA, Kuhnle G, Gibson GR, Debnam ES, Srai SK, et al. Colonic metabolism of dietary polyphenols: influence of structure on microbial fermentation products. Free Radic Biol Med 2004;36(2):212–25. doi: 10.1016/j.freeradbiomed.2003.09.022
   PubMed Web of Science ®Google Scholar
• Serra A, Macià A, Romero M-P, Reguant J, Ortega N, Motilva M-J. Metabolic pathways of the colonic metabolism of flavonoids (flavonols, flavones and flavanones) and phenolic acids. Food Chem 2012;130(2):383–93. doi: 10.1016/j.foodchem.2011.07.055
   Web of Science ®Google Scholar
• Choudhury R, Srai SK, Debnam E, Rice-Evans CA. Urinary excretion of hydroxycinnamates and flavonoids after oral and intravenous administration. Free Radic Biol Med 1999;27(3–4):278–86. doi: 10.1016/S0891-5849(99)00054-4
   PubMed Web of Science ®Google Scholar
• Tang D, Yin Y, Zhang Z, Gao Y, Wei Y, Chen Y, et al. Simultaneous HPLC-DAD analysis of five flavonoids in diabetic rat plasma and its application in the study of pharmacokinetics. Acta Chromatographica 2009;21(3):483–97. doi: 10.1556/AChrom.21.2009.3.11
   Web of Science ®Google Scholar
• Wang SY, Chai JY, Zhang WJ, Liu X, Du Y, Cheng ZZ, et al. HPLC determination of five polyphenols in rat plasma after intravenous administration of hawthorn leaves extract and its application to pharmacokinetic study. Yakugaku Zasshi 2010;130(11):1603–13. doi: 10.1248/yakushi.130.1603
   PubMed Web of Science ®Google Scholar
• Yang CY, Hsiu SL, Wen KC, Lin SP, Tsai SY, Hou YC, et al. Bioavailability and metabolic pharmacokinetics of rutin and quercetin in rats. J Food Drug Anal 2004;13(3):244–50.
   Web of Science ®Google Scholar
• Mladenka P, Hrdina R, Filipsky T, Riha M, Palicka V. Is a highly linear relationship between the dose of quercetin and the pharmacological effect possible? – a comment on Liu, et al. Evaluation of antioxidant and immunity activities of quercetin in isoproterenol-treated rats. Molecules 2012;17:4281–4291. Molecules 2014;19(7):9606–9. doi: 10.3390/molecules19079606
   PubMed Web of Science ®Google Scholar
• Manach C, Morand C, Demigne C, Texier O, Regerat F, Remesy C. Bioavailability of rutin and quercetin in rats. FEBS Lett 1997;409(1):12–6. doi: 10.1016/S0014-5793(97)00467-5
   PubMed Web of Science ®Google Scholar
• Ambrosio G, Zweier JL, Jacobus WE, Weisfeldt ML, Flaherty JT. Improvement of postischemic myocardial function and metabolism induced by administration of deferoxamine at the time of reflow: the role of iron in the pathogenesis of reperfusion injury. Circulation 1987;76(4):906–15. doi: 10.1161/01.CIR.76.4.906
   PubMed Web of Science ®Google Scholar
• Garcia-Lafuente A, Guillamon E, Villares A, Rostagno MA, Martinez JA. Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res 2009;58(9):537–52. doi: 10.1007/s00011-009-0037-3
   PubMed Web of Science ®Google Scholar
• Strobel NA, Fassett RG, Marsh SA, Coombes JS. Oxidative stress biomarkers as predictors of cardiovascular disease. Int J Cardiol 2011;147(2):191–201. doi: 10.1016/j.ijcard.2010.08.008
   PubMed Web of Science ®Google Scholar
• Mladenka P, Zatloukalova L, Filipsky T, Vavrova J, Holeckova M, Palicka V, et al. Common biomarkers of oxidative stress do not reflect cardiovascular dys/function in rats. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2013;157(2):146–52.
   PubMed Web of Science ®Google Scholar
• Haskova P, Kovarikova P, Koubkova L, Vavrova A, Mackova E, Simunek T. Iron chelation with salicylaldehyde isonicotinoyl hydrazone protects against catecholamine autoxidation and cardiotoxicity. Free Radic Biol Med 2011;50(4):537–49. doi: 10.1016/j.freeradbiomed.2010.12.004
   PubMed Web of Science ®Google Scholar
• Mladenka P, Kalinowski DS, Haskova P, Bobrovova Z, Hrdina R, Simunek T, et al. The novel iron chelator, 2-pyridylcarboxaldehyde 2-thiophenecarboxyl hydrazone, reduces catecholamine-mediated myocardial toxicity. Chem Res Toxicol 2009;22(1):208–17. doi: 10.1021/tx800331j
   PubMed Web of Science ®Google Scholar
• Costa VM, Silva R, Ferreira LM, Branco PS, Carvalho F, Bastos ML, et al. Oxidation process of adrenaline in freshly isolated rat cardiomyocytes: formation of adrenochrome, quinoproteins, and GSH adduct. Chem Res Toxicol 2007;20(8):1183–91. doi: 10.1021/tx7000916
   PubMed Web of Science ®Google Scholar
• Costa VM, Silva R, Ferreira R, Amado F, Carvalho F, de Lourdes Bastos M, et al. Adrenaline in pro-oxidant conditions elicits intracellular survival pathways in isolated rat cardiomyocytes. Toxicology 2009;257(1–2):70–9. doi: 10.1016/j.tox.2008.12.010
   PubMed Web of Science ®Google Scholar
• Milne GL, Musiek ES, Morrow JD. F2-isoprostanes as markers of oxidative stress in vivo: an overview. Biomarkers 2005;10(Suppl 1):S10–23. doi: 10.1080/13547500500216546
   PubMedGoogle Scholar