4-Vinylcyclohexene diepoxide disrupts sperm characteristics, endocrine balance and redox status in testes and epididymis of rats

References

• Saradha B, Mathur PP. Effect of environmental contaminants on male reproduction. Environ Toxicol Pharmacol. 2006;21:34–41. doi: 10.1016/j.etap.2005.06.004
   PubMed Web of Science ®Google Scholar
• Kumar V, Kural MR, Pereira BMJ, et al. Spearmint induced hypothalamic oxidative stress and testicular anti-androgenicity in male rats – altered levels of gene expression, enzymes and hormones. Food Chem Toxicol. 2008;46:3563–3570. doi: 10.1016/j.fct.2008.08.027
   PubMed Web of Science ®Google Scholar
• Adedara IA, Farombi EO. Chemoprotection of ethylene glycol monoethyl ether-induced reproductive toxicity in male rats by kolaviron, isolated biflavonoid from Garcinia kola seed. Hum Exp Toxicol. 2012;31:506–517. doi: 10.1177/0960327111424301
   PubMed Web of Science ®Google Scholar
• Rappaport SM, Fraser DA. Gas chromatographic–mass spectrometric identification of volatiles released from a rubber stock during simulated vulcanization. Anal. Chem. 1976;48:476–481. doi: 10.1021/ac60367a012
   Web of Science ®Google Scholar
• International Agency for Research on Cancer. 4-Vinylcyclohexene. In: IARC, editor. Monographs on the evaluation of carcinogenic risks to humans: some industrial chemicals, 60. Lyon: IARC; 1994. p. 347–359.
   Google Scholar
• Hu X, Flaws JA, Sipes IG, et al. Activation of mitogen-activated protein kinases and AP-1 transcription factor in ovotoxicity induced by 4-vinylcyclohexene diepoxide in rats. Biol Reprod. 2002;67:718–724. doi: 10.1095/biolreprod.102.004259
   PubMed Web of Science ®Google Scholar
• Keating AF, Mark CJ, Sen N, et al. Effect of phosphatidylinositol-3 kinase inhibition on ovotoxicity caused by 4-vinylcyclohexene diepoxide and 7, 12-dimethylbenz[a]anthracene in neonatal rat ovaries. Toxicol Appl Pharmacol. 2009;241:127–134. doi: 10.1016/j.taap.2009.08.012
   PubMed Web of Science ®Google Scholar
• Roosa KA, Mukai M, Place NJ. 4-Vinylcyclohexene diepoxide reduces fertility in female Siberian hamsters when treated during their reproductively active and quiescent states. Reprod Toxicol. 2015;51:40–46. doi: 10.1016/j.reprotox.2014.12.003
   PubMed Web of Science ®Google Scholar
• Chhabra RS, Elwell MR, Peters A. Toxicity of 4-vinyl-1-cyclohexene diepoxide after 13 weeks of dermal or oral exposure in rats and mice. Fundam Appl Toxicol. 1990;14:745–751. doi: 10.1016/0272-0590(90)90299-Y
   PubMedGoogle Scholar
• Abolaji AO, Toloyai P, Odeleye TD, et al. Hepatic and renal toxicological evaluations of an industrial ovotoxic chemical, 4-vinylcyclohexene diepoxide, in both sexes of Wistar rats. Environ Toxicol Pharmacol. 2016;45:28–40. doi: 10.1016/j.etap.2016.05.010
   PubMed Web of Science ®Google Scholar
• Hooser SB, DeMerell DG, Douds DA, et al. Testicular germ cell toxicity caused by vinylcyclohexene diepoxide in mice. Reprod Toxicol. 1995;9:359–67. doi: 10.1016/0890-6238(95)00022-3
   PubMed Web of Science ®Google Scholar
• Abolaji AO, Kamdem JP, Lugokenski TH, et al. Involvement of oxidative stress in 4-vinylcyclohexene-induced toxicity in Drosophila melanogaster. Free Radic Biol Med. 2014;71:99–108. doi: 10.1016/j.freeradbiomed.2014.03.014
   PubMed Web of Science ®Google Scholar
• Abolaji AO, Kamdem JP, Lugokenski TH, et al. Ovotoxicants 4-vinylcyclohexene 1,2-monoepoxide and 4-vinylcyclohexene diepoxide disrupt redox status and modify different electrophile sensitive target enzymes and genes in Drosophila melanogaster. Redox Biol. 2015;5:328–339. doi: 10.1016/j.redox.2015.06.001
   PubMed Web of Science ®Google Scholar
• Adedara IA, Farombi EO. Influence of kolaviron and vitamin E on ethylene glycol monoethyl ether-induced haematotoxicity and renal apoptosis in rats. Cell Biochem Funct. 2014;32:31–38. doi: 10.1002/cbf.2968
   PubMed Web of Science ®Google Scholar
• Saradha B, Vaithinathan S, Mathur PP. Lindane induces testicular apoptosis in adult Wistar rats through the involvement of Fas–FasL and mitochondria-dependent pathways. Toxicology. 2009;255:131–139. doi: 10.1016/j.tox.2008.10.016
   PubMed Web of Science ®Google Scholar
• Adedara IA, Vaithinathan S, Jubendradass R, et al. Kolaviron prevents carbendazim-induced steroidogenic dysfunction and apoptosis in testes of rats. Environ Toxicol Pharmacol. 2013;35:444–453. doi: 10.1016/j.etap.2013.01.010
   PubMed Web of Science ®Google Scholar
• Sharma RK, Agarwal A. Role of reactive oxygen species in male infertility. Urology. 1996;48:835–850. doi: 10.1016/S0090-4295(96)00313-5
   PubMed Web of Science ®Google Scholar
• Wang X, Sharma RK, Sikka SC, et al. Oxidative stress is associated with increased apoptosis leading to spermatozoa DNA damage in patients with male factor infertility. Fertil Steril. 2003;80:531–535. doi: 10.1016/S0015-0282(03)00756-8
   PubMed Web of Science ®Google Scholar
• Devine PJ, Sipes IG, Hoyer PB. Effect of 4-vinylcyclohexene diepoxide dosing in rats on GSH levels in liver and ovaries. Toxicol Sci. 2001;62:315–320. doi: 10.1093/toxsci/62.2.315
   PubMed Web of Science ®Google Scholar
• Zemjanis R. Collection and evaluation of semen. In: Zemjanis R, editor. Diagnostic and therapeutic technique in animal reproduction. 2nd ed. Baltimore (MD): William and Wilkins Company, Waverly Press, Inc; 1970. p. 139–153.
   Google Scholar
• World Health Organization. Collection and examination of human semen. In: Aitken RJ, Comhaire F, Baker HWG, Cooper TG, Barratt CLR, De Jonge C, Behre HM, Elasson R, editors. WHO Laboratory Manual for the examination of human semen and sperm-cervical mucus interaction. 4th ed. UK: Cambridge University Press; 1999. p. 4–33.
   Google Scholar
• Wells ME, Awa OA. New technique for assessing acrosomal characteristics of spermatozoa. J Diary Sci. 1970;53:227. doi: 10.3168/jds.S0022-0302(70)86184-7
   PubMed Web of Science ®Google Scholar
• Blazak WF, Trienen KA, Juniewicz PE. Application of testicular sperm head counts in the assessment of male reproductive toxicity. In: RE Chapin, J Heindel, editors. Methods in toxicology, Vol. 3A, Male reproductive toxicology. San Diego: Academic Press; 1993. p. 86–94.
   Google Scholar
• Hess RA. Quantitative and qualitative characteristics of the stages and transitions in the cycle of the rat seminiferous epithelium: light microscopic observations of perfusion-fixed and plastic-embedded testes. Biol Reprod. 1990;43:525–542. doi: 10.1095/biolreprod43.3.525
   PubMed Web of Science ®Google Scholar
• Amann RP, Johnson L, Thompson DL, et al. Daily spermatozoal production, epididymal spermatozoal reserves and transit time of spermatozoa through the epididymis of the rhesus monkey. Biol Reprod. 1976;15:586–592. doi: 10.1095/biolreprod15.5.586
   PubMed Web of Science ®Google Scholar
• Lowry OH, Rosenbrough NJ, Farr AL, et al. Protein measurement with Folin phenol reagent. J Biol Chem. 1951;193:265–275.
   PubMed Web of Science ®Google Scholar
• Misra HP, Fridovich I. The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem. 1972;247:3170–3175.
   PubMed Web of Science ®Google Scholar
• Clairborne A. Catalase activity. In: AR Greewald, editor. Handbook of methods for oxygen radical research. Boca Raton: CRC Press; 1995. p. 237–242.
   Google Scholar
• Rotruck JT, Pope AL, Ganther HE, et al. Selenium: biochemical role as a component of glutathione peroxidase. Science. 1973;179:588–590. doi: 10.1126/science.179.4073.588
   PubMed Web of Science ®Google Scholar
• Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferase. The first enzymatic step in mercapturic acid formation. J Biol Chem. 1974;249:7130–7139.
   PubMed Web of Science ®Google Scholar
• Jollow DJ, Mitchell JR, Zampaglione N, et al. Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology. 1974;11:151–169. doi: 10.1159/000136485
   PubMed Web of Science ®Google Scholar
• Wolff SP. Ferrous ion oxidation in the presence of ferric ion indicator xylenol orange for measurement of hydroperoxides. Methods Enzymol. 1994;233:182–189. doi: 10.1016/S0076-6879(94)33021-2
   Web of Science ®Google Scholar
• Farombi EO, Tahnteng JG, Agboola AO, et al. Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron – a Garcinia kola seed extract. Food Chem Toxicol. 2000;38:535–541. doi: 10.1016/S0278-6915(00)00039-9
   PubMed Web of Science ®Google Scholar
• Bancroft JD, Gamble M. Theory and practice of histology techniques. 6th ed. London: Churchill Livingstone Elsevier; 2008; p. 83–134.
   Google Scholar
• Kaur P, Kaur G, Bansal MP. Tertiary-butyl hydroperoxide induced oxidative stress and male reproductive activity in mice: role of transcription factor NF-kappaB and testicular antioxidant enzymes. Reprod Toxicol. 2006;22:479–484. doi: 10.1016/j.reprotox.2006.03.017
   PubMed Web of Science ®Google Scholar
• Farombi EO, Adedara IA, Akinrinde SA, et al. Protective effects of kolaviron and quercetin on cadmium-induced testicular damage and endocrine pathology in rat. Andrologia. 2012;44:273–284. doi: 10.1111/j.1439-0272.2012.01279.x
   PubMed Web of Science ®Google Scholar
• Valko M, Leibfritz D, Moncol J, et al. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39:44–84. doi: 10.1016/j.biocel.2006.07.001
   PubMed Web of Science ®Google Scholar
• Demir E, Kaya B, Soriano C, et al. Genotoxic analysis of four lipid-peroxidation products in the mouse lymphoma assay. Mutat Res. 2011;726:98–103. doi: 10.1016/j.mrgentox.2011.07.001
   PubMed Web of Science ®Google Scholar
• Adedara IA, Awogbindin IO, Adesina AA, et al. Municipal landfill leachate-induced testicular oxidative damage is associated with biometal accumulation and endocrine disruption in rats. Arch Environ Contam Toxicol. 2015;68:74–82. doi: 10.1007/s00244-014-0075-x
   PubMed Web of Science ®Google Scholar
• Russell LD, Alger LF, Naquin LG. Hormonal control of pubertal spermatogenesis. Endocrinology. 1987;120:1615–1632. doi: 10.1210/endo-120-4-1615
   PubMed Web of Science ®Google Scholar
• Sriraman V, Anbalagan M, Rao AJ. Hormonal regulation of Leydig cell proliferation and differentiation in rodent testis: a dynamic interplay between gonadotrophins and testicular factors. Reprod Biomed. 2005;11:507–518. doi: 10.1016/S1472-6483(10)61147-9
   PubMed Web of Science ®Google Scholar
• Yakubu MT, Akanji MA, Oladiji AT, et al. Androgenic potentials of aqueous extract of Massularia acuminata (G. Don) Bullockex Hoyl stem in male Wistar rats. J Ethnopharmacol. 2008;118:508–513. doi: 10.1016/j.jep.2008.05.020
   PubMed Web of Science ®Google Scholar
• Yoshida S, Hiyoshi K, Ichinose T, et al. Effect of nanoparticles on the male reproductive system of mice. Int J Androl. 2009;32:337–342. doi: 10.1111/j.1365-2605.2007.00865.x
   PubMed Web of Science ®Google Scholar
• Farombi EO, Adedara IA, Ebokaiwe AP, et al. Nigerian Bonny light crude oil disrupts antioxidant systems in the testes and sperm of rats. Arch Environ Contam Toxicol. 2010;59:166–174. doi: 10.1007/s00244-009-9443-3
   PubMed Web of Science ®Google Scholar
• Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell. 2004;116:205–219. doi: 10.1016/S0092-8674(04)00046-7
   PubMed Web of Science ®Google Scholar
• Gao HB, Tong MH, Hu YQ, et al. Mechanisms of glucocorticoid-induced Leydig cell apoptosis. Mol Cell Endocrinol. 2003;199:153–163. doi: 10.1016/S0303-7207(02)00290-3
   PubMed Web of Science ®Google Scholar