Publication Cover
Redox Report
Communications in Free Radical Research
Volume 27, 2022 - Issue 1
8,174
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Lycium Barbarum polysaccharide protects HaCaT cells from PM2.5-induced apoptosis via inhibiting oxidative stress, ER stress and autophagy

, , , , & ORCID Icon

References

  • Li R, Zhou R, Zhang J. Function of PM2.5 in the pathogenesis of lung cancer and chronic airway inflammatory diseases. Oncol Lett. 2018;15:7506–7514. doi:10.3892/ol.2018.8355.
  • Wang Y, Tang M. PM2.5 induces autophagy and apoptosis through endoplasmic reticulum stress in human endothelial cells. Sci Total Environ. 2020;710:136397. doi:10.1016/j.scitotenv.2019.136397.
  • Zhao C, Wang Y, Su Z, et al. Respiratory exposure to PM2.5 soluble extract disrupts mucosal barrier function and promotes the development of experimental asthma. Sci Total Environ. 2020;730:139145. doi:10.1016/j.scitotenv.2020.139145.
  • Schikowski T, Krutmann J. Air pollution (particulate matter and nitrogen dioxide) and skin aging. Hautarzt. 2019;70:158–162. doi:10.1007/s00105-018-4338-8.
  • Ryu YS, Kang KA, Piao MJ, et al. Particulate matter-induced senescence of skin keratinocytes involves oxidative stress-dependent epigenetic modifications. Exp Mol Med. 2019;51:1–14. doi:10.1038/s12276-019-0305-4.
  • Ryu YS, Kang KA, Piao MJ, et al. Particulate matter induces inflammatory cytokine production via activation of NFκB by TLR5-NOX4-ROS signaling in human skin keratinocyte and mouse skin. Redox Biol. 2019;21:101080. doi:10.1016/j.redox.2018.101080.
  • Li Q, Kang Z, Jiang S, et al. Effects of ambient fine particles PM(2.5) on human HaCaT cells. Int J Environ Res Public Health. 2017;14:72. doi:10.3390/ijerph14010072.
  • Hu R, Xie XY, Xu SK, et al. PM(2.5) exposure elicits oxidative stress responses and mitochondrial apoptosis pathway activation in HaCaT keratinocytes. Chin Med J (Engl). 2017;130:2205–2214. doi:10.4103/0366-6999.212942.
  • Piao MJ, Ahn MJ, Kang KA, et al. Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis. Arch Toxicol. 2018;92:2077–2091. doi:10.1007/s00204-018-2197-9.
  • Chen X, Cubillos-Ruiz JR. Endoplasmic reticulum stress signals in the tumour and its microenvironment. Nat Rev Cancer. 2021;21:71–88. doi:10.1038/s41568-020-00312-2.
  • Lebeaupin C, Vallée D, Hazari Y, et al. Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease. J Hepatol. 2018;69:927–947. doi:10.1016/j.jhep.2018.06.008.
  • Iurlaro R, Muñoz-Pinedo C. Cell death induced by endoplasmic reticulum stress. Febs J. 2016;283:2640–2652. doi:10.1111/febs.13598.
  • Dikic I, Elazar Z. Mechanism and medical implications of mammalian autophagy. Nat Rev Mol Cell Biol. 2018;19:349–364. doi:10.1038/s41580-018-0003-4.
  • He R, Wang Z, Cui M, et al. HIF1A alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy. Autophagy. 2021;17:3338–3360. doi:10.1080/15548627.2021.1872227.
  • Fu YW, Peng YF, Huang XD, et al. Lycium barbarum polysaccharide-glycoprotein preventative treatment ameliorates aversive. Neural Regen Res. 2021;16:543–549. doi:10.4103/1673-5374.293156.
  • Tian X, Liang T, Liu Y, et al. Extraction, structural characterization, and biological functions of lycium barbarum polysaccharides: a review. Biomolecules. 2019;9:389. doi:10.3390/biom9090389.
  • Li H, Li Z, Peng L, et al. Lycium barbarum polysaccharide protects human keratinocytes against UVB-induced photo-damage. Free Radic Res. 2017;51:200–210. doi:10.1080/10715762.2017.1294755.
  • Li X, Mo X, Liu T, et al. Efficacy of Lycium barbarum polysaccharide in adolescents with subthreshold depression: interim analysis of a randomized controlled study. Neural Regen Res. 2022;17:1582–1587. doi:10.4103/1673-5374.330618.
  • Wang Y, Wei W, Guo M, et al. Lycium barbarum polysaccharide promotes M2 polarization of BV2 microglia induced by LPS via inhibiting the TLR4/NF-κB signaling pathway. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2021;37:1066–1072.
  • Liang R, Zhao Q, Zhu Q, et al. Lycium barbarum polysaccharide protects ARPE-19 cells against H(2)O(2)–induced oxidative stress via the Nrf2/HO–1 pathway. Mol Med Rep. 2021;24:769. doi:10.3892/mmr.2021.12409.
  • Pan H, Niu L, Wu Y, et al. Lycium barbarum polysaccharide protects rats and cardiomyocytes against ischemia/reperfusion injury via Nrf2 activation through autophagy inhibition. Mol Med Rep. 2021;24:778. doi:10.3892/mmr.2021.12418.
  • Liang B, Peng L, Li R, et al. Lycium barbarum polysaccharide protects HSF cells against ultraviolet-induced damage through the activation of Nrf2. Cell Mol Biol Lett. 2018;23:18. doi:10.1186/s11658-018-0084-2.
  • Hu L, Guo J, Zhou L, et al. Hydrogen sulfide protects retinal pigment epithelial cells from oxidative stress-induced apoptosis and affects autophagy. Oxid Med Cell Longev. 2020;2020:8868564. doi:10.1155/2020/8868564.
  • Molagoda IMN, Kavinda MHD, Choi YH, et al. Fisetin protects HaCaT human keratinocytes from fine particulate matter (PM(2.5))-induced oxidative stress and apoptosis by inhibiting the endoplasmic reticulum stress response. Antioxidants (Basel). 2021;10:1492. doi:10.3390/antiox10091492.
  • Fernando P, Piao MJ, Zhen AX, et al. Extract of cornus officinalis protects keratinocytes from particulate matter-induced oxidative stress. Int J Med Sci. 2020;17:63–70. doi:10.7150/ijms.36476.
  • Alfaro IE, Albornoz A, Molina A, et al. Chaperone mediated autophagy in the crosstalk of neurodegenerative diseases and metabolic disorders. Front Endocrinol (Lausanne). 2018;9:778. doi:10.3389/fendo.2018.00778.
  • Zhang L, Yao Z, Ji G. Herbal extracts and natural products in alleviating non-alcoholic fatty liver disease via activating autophagy. Front Pharmacol. 2018;9:1459. doi:10.3389/fphar.2018.01459.
  • Sanford JA, Gallo RL. Functions of the skin microbiota in health and disease. Semin Immunol. 2013;25:370–377. doi:10.1016/j.smim.2013.09.005.
  • Park CG, Cho HK, Shin HJ, et al. Comparison of mutagenic activities of various ultra-fine particles. Toxicol Res. 2018;34:163–172. doi:10.5487/tr.2018.34.2.163.
  • Magnani ND, Muresan XM, Belmonte G, et al. Skin damage mechanisms related to airborne particulate matter exposure. Toxicol Sci. 2016;149:227–236. doi:10.1093/toxsci/kfv230.
  • Sah D, Verma PK, Kumari KM, et al. Chemical partitioning of fine particle-bound As,: Cd, Cr, Ni, Co, Pb and assessment of associated cancer risk due to inhalation, ingestion and dermal exposure. Inhal Toxicol. 2017;29:483–493. doi:10.1080/08958378.2017.1406563.
  • Suo D, Zeng S, Zhang J, et al. PM2.5 induces apoptosis,: oxidative stress injury and melanin metabolic disorder in human melanocytes. Exp Ther Med. 2020;19:3227–3238. doi:10.3892/etm.2020.8590.
  • Ni H, Wang G, Xu Y, et al. Lycium barbarum polysaccharide alleviates IL-1β-evoked chondrogenic ATDC5 cell inflammatory injury through mediation of microRNA-124. Artif Cells Nanomed Biotechnol. 2019;47:4046–4052. doi:10.1080/21691401.2019.1673765.
  • Yi R, Liu XM, Dong Q. A study of Lycium barbarum polysaccharides (LBP) extraction technology and its anti-aging effect. Afr J Tradit Complement Altern Med. 2013;10:171–174. doi:10.4314/ajtcam.v10i4.27.
  • Chen L, Li W, Qi D, et al. Lycium barbarum polysaccharide protects against LPS-induced ARDS by inhibiting apoptosis,: oxidative stress, and inflammation in pulmonary endothelial cells. Free Radic Res. 2018;52:480–490. doi:10.1080/10715762.2018.1447105.
  • Wang Y, Zhang X, Wen Y, et al. Endoplasmic reticulum-mitochondria contacts: a potential therapy target for cardiovascular remodeling-associated diseases. Front Cell Dev Biol. 2021;9:774989. doi:10.3389/fcell.2021.774989.
  • Qiao D, Zhang Z, Zhang Y, et al. Regulation of endoplasmic reticulum stress-autophagy: a potential therapeutic target for ulcerative colitis. Front Pharmacol. 2021;12:697360. doi:10.3389/fphar.2021.697360.
  • Piao MJ, Kang KA, Zhen AX, et al. Particulate matter 2.5 mediates cutaneous cellular injury by inducing mitochondria-associated endoplasmic reticulum stress: protective effects of ginsenoside Rb1. Antioxidants (Basel). 2019;8:383. doi:10.3390/antiox8090383.
  • Guo Y, Zhang X, Wu T, et al. Autophagy in skin diseases. Dermatology. 2019;235:380–389. doi:10.1159/000500470.
  • Dai Y, Wang Y, Lu S, et al. Autophagy attenuates particulate matter 2.5-induced damage in HaCaT cells. Ann Transl Med. 2021;9:978. doi:10.21037/atm-21-2146.
  • Livingston MJ, Wang J, Zhou J, et al. Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys. Autophagy. 2019;15:2142–2162. doi:10.1080/15548627.2019.1615822.
  • Chen Y, Chen HN, Wang K, et al. Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma. J Hepatol. 2019;70:66–77. doi:10.1016/j.jhep.2018.09.022.
  • Chen YP, Shih PC, Feng CW, et al. Pardaxin activates excessive mitophagy and mitochondria-mediated apoptosis in human ovarian cancer by inducing reactive oxygen species. Antioxidants (Basel). 2021;10:1883. doi:10.3390/antiox10121883.