550
Views
21
CrossRef citations to date
0
Altmetric
Review

An update on PTEN modulators – a patent review

, &
Pages 881-889 | Received 21 May 2019, Accepted 16 Sep 2019, Published online: 23 Sep 2019

References

  • Maehama T, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem. 1998;273(22):13375–13378.
  • Song MS, Salmena L, Pandolfi PP. The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol. 2012;13(5):283–296.
  • Lee YR, Chen M, Pandolfi PP. The functions and regulation of the PTEN tumour suppressor: new modes and prospects. Nat Rev Mol Cell Biol. 2018;19(9):547–562.
  • Boosani CS, Agrawal DK. PTEN modulators: a patent review. Expert Opin Ther Pat. 2013;23(5):569–580.
  • Milella M, Falcone I, Conciatori F, et al. PTEN: multiple functions in human malignant tumors. Front Oncol. 2015;5:24.
  • van Diepen MT, Parsons M, Downes CP, et al. MyosinV controls PTEN function and neuronal cell size. Nat Cell Biol. 2009;11(10):1191–1196.
  • Gomes AM, Soares MV, Ribeiro P, et al. Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels. Haematologica. 2014;99(6):1062–1068.
  • Trotman LC, Wang X, Alimonti A, et al. Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell. 2007;128(1):141–156.
  • Vazquez F, Grossman SR, Takahashi Y, et al. Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J Biol Chem. 2001;276(52):48627–48630.
  • Vazquez F, Ramaswamy S, Nakamura N, et al. Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol. 2000;20(14):5010–5018.
  • Torres J, Pulido R. The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. J Biol Chem. 2001;276(2):993–998.
  • Park KK, Liu K, Hu Y, et al. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science (New York, NY). 2008;322(5903):963–966.
  • O’Donovan KJ, Ma K, Guo H, et al. B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS. J Exp Med. 2014;211(5):801–814.
  • de Lima S, Habboub G, Benowitz LI. Combinatorial therapy stimulates long-distance regeneration, target reinnervation, and partial recovery of vision after optic nerve injury in mice. Int Rev Neurobiol. 2012;106:153–172.
  • de Lima S, Koriyama Y, Kurimoto T, et al. Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors. Proc Natl Acad Sci U S A. 2012;109(23):9149–9154.
  • Kurimoto T, Yin Y, Omura K, et al. Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion. J Neurosci. 2010;30(46):15654–15663.
  • Leibinger M, Andreadaki A, Fischer D. Role of mTOR in neuroprotection and axon regeneration after inflammatory stimulation. Neurobiol Dis. 2012;46(2):314–324.
  • Sun F, Park KK, Belin S, et al. Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature. 2011;480(7377):372–375.
  • Gallaher ZR, Steward O. Modest enhancement of sensory axon regeneration in the sciatic nerve with conditional co-deletion of PTEN and SOCS3 in the dorsal root ganglia of adult mice. Exp Neurol. 2018;303:120–133.
  • Mak LH, Vilar R, Woscholski R. Characterisation of the PTEN inhibitor VO-OHpic. J Chem Biol. 2010;3(4):157–163.
  • Rosivatz E, Matthews JG, McDonald NQ, et al. A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem Biol. 2006;1(12):780–790.
  • Schmid AC, Byrne RD, Vilar R, et al. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett. 2004;566(1–3):35–38.
  • Zhang ZF, Chen J, Han X, et al. Bisperoxovandium (pyridin-2-squaramide) targets both PTEN and ERK1/2 to confer neuroprotection. Br J Pharmacol. 2017;174(8):641–656.
  • Christie KJ, Webber CA, Martinez JA, et al. PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons. J Neurosci. 2010;30(27):9306–9315.
  • Walker CL, Walker MJ, Liu NK, et al. Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury. PloS One. 2012;7(1):e30012.
  • Walker CL, Xu XM. PTEN inhibitor bisperoxovanadium protects oligodendrocytes and myelin and prevents neuronal atrophy in adult rats following cervical hemicontusive spinal cord injury. Neurosci Lett. 2014;573:64–68.
  • Zhao J, Qu Y, Wu J, et al. PTEN inhibition prevents rat cortical neuron injury after hypoxia-ischemia. Neuroscience. 2013;238:242–251.
  • Li S. InventorPten antagonist peptides and methods of using the same. US patent US10011638B2. 2016.
  • Lee KH, Noh MJ, Ahn K. InventorsTreatment of damaged nerve with pten inhibitor. US patent WO2015066701A1. 2016.
  • Boosani CS, Nalabothula N, Munugalavadla V, et al. FAK and p38-MAP kinase-dependent activation of apoptosis and caspase-3 in retinal endothelial cells by alpha1(IV)NC1. Invest Ophthalmol Vis Sci. 2009;50(10):4567–4575.
  • Boosani CS, Nalabothula N, Sheibani N, et al. Inhibitory effects of arresten on bFGF-induced proliferation, migration, and matrix metalloproteinase-2 activation in mouse retinal endothelial cells. Curr Eye Res. 2010;35(1):45–55.
  • Vavvas D, Miller JW, Takeuchi K. InventorsTreating ocular neovascularization. US patent US10143703B2. 2017.
  • Theodoropoulou S, Kolovou PE, Morizane Y, et al. Retinoblastoma cells are inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase. Faseb J. 2010;24(8):2620–2630.
  • Webb T, Wang Z. InventorsCompositions and methods of making expanded hematopoietic stem cells using pten inhibitors. US patent WO2018217567A1. 2018.
  • Yue F, Bi P, Wang C, et al. Pten is necessary for the quiescence and maintenance of adult muscle stem cells. Nat Commun. 2017;8:14328.
  • Duan S, Yuan G, Liu X, et al. PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Nat Commun. 2015;6:10068.
  • Zhang G, Wang W, Yao C, et al. Radiation-resistant cancer stem-like cell properties are regulated by PTEN through the activity of nuclear beta-catenin in nasopharyngeal carcinoma. Oncotarget. 2017;8(43):74661–74672.
  • Yilmaz OH, Valdez R, Theisen BK, et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature. 2006;441(7092):475–482.
  • Schubbert S, Jiao J, Ruscetti M, et al. Methods for PTEN in stem cells and cancer stem cells. Methods Mol Biol. 2016;1388:233–285.
  • Qin G, Xie J, Chen L, et al. PTEN inhibition preserves trigeminal nucleus caudalis neuron activation through tyrosine phosphorylation of the NR2B subunit at Tyr1472 of the NMDA receptor in a rat model of recurrent migraine. Neurol Res. 2016;38(4):320–326.
  • Huang SY, Sung CS, Chen WF, et al. Involvement of phosphatase and tensin homolog deleted from chromosome 10 in rodent model of neuropathic pain. J Neuroinflammation. 2015;12:59.
  • Wen Z-H, Tai M-H, Huang S-Y, et al. InventorsMethod for treating pain and method for screening pharmaceutical compositions having an anti-pain effect. TW patent US9999658B2. 2018.
  • Pulido R. PTEN inhibition in human disease therapy. Molecules. 2018;23(2). DOI:10.3390/molecules23020285
  • Dave VG, Cai J. InventorsPten binding compounds, formulations, and uses thereof. US patent WO2018151835A1. 2018.
  • Li H, Wang P, Sun Q, et al. Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1. Cancer Res. 2011;71(10):3625–3634.
  • Petit A, Kawarai T, Paitel E, et al. Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations. J Biol Chem. 2005;280(40):34025–34032.
  • Reggiori F, Tucker KA, Stromhaug PE, et al. The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure. Dev Cell. 2004;6(1):79–90.
  • Woon KD, Eun-hee C, Min-hee L, et al. InventorsComposition for diagnosing neuropathic pain comprising PTEN-induced putative kinase 1. KR patent KR101847608B1. 2018.
  • Jo M, Imsang S, Lee SY, et al. InventorsComposition for treatment or prevention of autoimmune diseases comprising PTEN-induced kinase 1 protein or nucleotide. KR patent KR 101712695B1. 2017.
  • Vali S, Usmani S, Sultana Z, et al. InventorsCombination of nelfinavir, metformin and rosuvastatin for treating cancer caused by aberrations in pten/tp53. US patent US10098880B2. 2017.
  • Kaur B. InventorExpression of pten-long with ocolytic viruses. US patent WO2018023114A1. 2018.
  • Jean S, Kiger AA. Classes of phosphoinositide 3-kinases at a glance. J Cell Sci. 2014;127(Pt 5):923–928.
  • Stern HM, Kutok JL. Inventorstreatment of cancers using PI3 kinase isoform modulators. US patent US20140377258A1. 2014.
  • Kim TW, Jin DH, Hong SW, et al. InventorsComposition for treatment or metastasis suppression of cancers which includes p34 expression inhibitor or activity inhibitor as active ingredient. KR patent US9752151B2. 2017.
  • Mathur D, Stratikopoulos E, Ozturk S, et al. PTEN regulates glutamine flux to pyrimidine synthesis and sensitivity to dihydroorotate dehydrogenase inhibition. Cancer Discov. 2017;7(4):380–390.
  • Parsons R, Mathur D, Stratikopoulos I. InventorsMethods for treating pten-mutant tumors. US patent WO2018038886A1. 2018.
  • Munn D, Mellor A. InventorsMethods and compositions for treating cancer. US patent WO2017004167A1. 2017.
  • Lee Y-M, Oh SY. InventorsPharmaceutical composition comprising MicroRNA-30B, MicroRNA-133A, or MicroRNA-202-5P inhibitor for inhibiting cancer. KR patent US9295709B2. 2016.
  • Wickstrom E, Jin YY, Wickstrom E, et al. InventorsCompositions and methods of using microrna inhibitors. US patent WO2015123449A2. 2015.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.