Advanced search
Publication Cover
Expert Opinion on Therapeutic Patents Volume 30, 2020 - Issue 7
Submit an article Journal homepage
3,822
Views
23
CrossRef citations to date
0
Altmetric
Editorial

A deadly spillover: SARS-CoV-2 outbreak

Mattia Moria Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2022, University of Siena, Siena, ItalyORCID Iconhttps://orcid.org/0000-0003-2398-1254View further author information
ORCID Icon,
Clemente Capassob Department of Biology, Agriculture and Food Sciences, CNR, Institute of Biosciences and Bioresources, CNR, Napoli, ItalyORCID Iconhttps://orcid.org/0000-0003-3314-2411View further author information
ORCID Icon,
Fabrizio Cartac Dipartimento Neurofarba, Sezione Di Scienze Farmaceutiche E Nutraceutiche, Università Degli Studi Di Firenze, Sesto Fiorentino (Florence), ItalyView further author information
,
William a Donaldd School of Chemistry, University of New South Wales, Sydney, New South Wales, AustraliaView further author information
&
Claudiu T Supuranc Dipartimento Neurofarba, Sezione Di Scienze Farmaceutiche E Nutraceutiche, Università Degli Studi Di Firenze, Sesto Fiorentino (Florence), ItalyCorrespondence[email protected]
View further author information
Pages 481-485 | Received 23 Mar 2020, Accepted 22 Apr 2020, Published online: 29 Apr 2020

References

  • Ksiazek TG, Erdman D, Goldsmith CS, et al. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med. 2003;348:1953–1966.
  • Hui DS, Azhar EI, Kim YJ, et al. Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission. Lancet Infect Dis. 2018;18:e217–e227.
  • Guarner J. Three emerging coronaviruses in two decades. Am J Clin Pathol. 2020;153:420–421.
  • Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382:727–733.
  • Woo PC, Huang Y, Lau SK, et al. Coronavirus genomics and bioinformatics analysis. Viruses. 2010;2:1804–1820.
  • Killerby ME, Biggs HM, Midgley CM, et al. Middle East respiratory syndrome coronavirus transmission. Emerg Infect Dis. 2020;26:191–198.
  • Li X, Zai J, Zhao Q, et al. Evolutionary history, potential intermediate animal host, and cross-species analyses of SARS-CoV-2. J Med Virol. 2020. In press. DOI:10.1002/jmv.25731.
  • Quammen D. Spillover: animal infections and the next human pandemic. New York: W.W. Norton and Co.; 2012. p. 1–608.
  • Jin Z, Du X, Xu Y, et al. Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature. 2020. in press. DOI:10.1038/s41586-020-2223-y.
  • Niemeyer D, Mösbauer K, Klein EM, et al. The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species. PLoS Pathog. 2018 Sep;24(14):e1007296.
  • Wang F, Chen C, Tan W, et al. Structure of main protease from human coronavirus NL63: insights for wide spectrum anti-coronavirus drug design. Sci Rep. 2016;6(1):22677.
  • Zhang L, Lin D, Sun X, et al. Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors. Science. 2020;pii:eabb3405. In press.
  • Zhang L, Lin D, Kusov Y, et al. α-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication: structure-based design, synthesis, and activity assessment. J Med Chem. 2020. In press. DOI:10.1021/acs.jmedchem.9b01828.
  • Ma-Lauer Y, Carbajo-Lozoya J, Hein MY, et al. p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1. Proc Natl Acad Sci U S A. 2016;113:E5192–5201.
  • Wang L, Bao BB, Song GQ, et al. Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease: chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study. Eur J Med Chem. 2017;137:450–461.
  • Rabaan AA, Alahmed SH, Bazzi AM, et al. a review of candidate therapies for middle East respiratory syndrome from a molecular perspective. J Med Microbiol. 2017;66:1261–1274.
  • Yao TT, Qian JD, Zhu WY, et al. a systematic review of lopinavir therapy for SARS coronavirus and MERS coronavirus-a possible reference for coronavirus disease-19 treatment option. J Med Virol. 2020. In press. DOI:10.1002/jmv.25729.
  • Lin MH, Moses DC, Hsieh CH, et al. Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes. Antiviral Res. 2018;150:155–163.
  • Li G, De Clercq E. Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Discov. 2020;19:149–150.
  • Warren TK, Jordan R, Lo MK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016;531:381–385.
  • Al-Tawfiq JA, Al-Homoud AH, Memish ZA. Remdesivir as a possible therapeutic option for the COVID-19. Travel Med Infect Dis. 2020: 101615. In press. doi:10.1016/j.tmaid.2020.101615.
  • Wang N, Shang J, Jiang S, et al. Subunit vaccines against emerging pathogenic human Coronaviruses. Front Microbiol. 2020;11:298.
  • Wang X, Xu W, Hu G, et al. SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion. Cell Mol Immunol. 2020. In press. DOI:10.1038/s41423-020-0424-9.
  • Xia S, Liu M, Wang C, et al. Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cell Res. 2020;30:343–355.
  • Ioannidis JPA. Coronavirus disease 2019: the harms of exaggerated information and non-evidence-based measures. Eur J Clin Invest. 2020;e13223. DOI:10.1111/eci.13223

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.