Mechanistically acting anti-obesity compositions/formulations of natural origin: a patent review (2010–2021)

References

• Grundy S, Brewer H, Cleeman J, et al. Definition of metabolic syndrome: report of the National heart, lung, and blood Institute/American Heart Association conference on scientific issues related to definition. Circulation. 2004;109( 3):433–438.
   Google Scholar
• Lebovitz HE, Banerji MA. Point: visceral adiposity is causally related to insulin resistance. Diabetes Care. 2005;28(9):2322–2325.
   PubMed Web of Science ®Google Scholar
• Stunkard AJ. Current views on obesity. Am J Med. 1996;100(2):230–236.
   PubMed Web of Science ®Google Scholar
• *Anonymous. Obesity preventing and managing the global epidemic. World Health Organization, Geneva. 1998:1–158.
   Google Scholar
• **Anonymous. Obesity and overweight. World Health Organisation. 2018. [cited 2020 Nov 27]. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
   Google Scholar
• Hales C, Carroll M, Fryar C, et al. Prevalence of obesity among adults and youth: united States, 2015–2016 *. Maryland: National Center Health Statistics (NCHS); 2017. p. 1–8.
   Google Scholar
• *Pradeepa R, Anjana R, Joshi S, et al. Prevalence of generalized and abdominal obesity in urban & rural India- the ICMR-INDIAB study (phase-I). Ind J Med Res. 2015;142(2):139–150. .
   PubMedGoogle Scholar
• **Ritchie H, Roser M Obesity Our World in Data 2020. [cited 2020 Nov 27]. http://ourworldindata.org/obesity.
   Google Scholar
• **Finkelstein E, Khavjou O, Thompson H, et al. Obesity and severe obesity forecasts through 2030. Am J Prev Med. 2012;42(6):563–570. .
   PubMed Web of Science ®Google Scholar
• Anonymous. Obesity: preventing and managing the global epidemic. World Health Organizaton; Geneva. 2000; 1–68.
   Google Scholar
• Kazemipoor M, Radzi C, Cordell G, et al. Potential of traditional medicinal plants for treating obesity: a Review. ICNFS. 2012;39(5):164–169.
   Google Scholar
• Mohamed GA, Ibrahim SRM, Elkhayat ES, et al. Natural anti-obesity agents. Bull Fac Pharm Cairo Univ. 2014;52(2):269–284.
   Google Scholar
• Hanl K, Kimura Y, Okuda H. Anti-obesity effects of natural products. In: Rahman A, editor. Studies in Natural Products Chemistry. Vol. 30. Japan: Elsevier; 2005. p. 79–110.
   Google Scholar
• Shi Y, Burn P. Lipid metabolic enzymes: emerging drug targets for the treatment of obesity. Nat Rev Drug Discov. 2004;3(8):695–710.
   PubMed Web of Science ®Google Scholar
• Trzeciak-Ryczek A, Tokarz-Deptuła B, Niedźwiedzka-Rystwej P, et al. Adipose tissue - Component of the immune system. Cent Eur J Immunol. 2011;36(2):95–99.
   Web of Science ®Google Scholar
• Walston J, Silver K, Bogardus C, et al. Time of Onset of Non-Insulin-Dependent Diabetes Mellitus and Genetic Variation in the 3-Adrenergic–Receptor Gene. N Engl J Med. 1995;333(6):343–347. .
   PubMed Web of Science ®Google Scholar
• Barbieri M, Rizzo MR, Papa M, et al. Role of interaction between variants in the PPAR-γ and Interleukin-6 genes on obesity related metabolic risk factors. Exp Gerontol. 2005;40(7):599–604. .
   PubMed Web of Science ®Google Scholar
• Deeb SS, Fajas L, Nemoto M, et al. A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet. 1998;20(3):284–287. .
   PubMed Web of Science ®Google Scholar
• Rosmond R, Chagnon M, Bouchard C. The Pro12Ala PPARγ2 gene missense mutation is associated with obesity and insulin resistance in Swedish middle-aged men. Diabetes Metab Res Rev. 2003;19(2):159–163.
   PubMed Web of Science ®Google Scholar
• Kurokawa N, Young EH, Oka Y, et al. The ADRb3 Trp64Arg variant and BMI: a meta-analysis of 44833 individuals. Int J Obes. 2008;32(8):1240–1249. .
   Web of Science ®Google Scholar
• Fernández-Real JM, Broch M, Vendrell J, et al. Interleukin-6 gene polymorphism and insulin sensitivityI. Diabetes Metab Res Rev. 2000;49(3):517–520.
   Google Scholar
• Kubaszek A, Pihlajamäki J, Punnonen K, et al. The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity. Diabetes. 2003;52(2):558–561. .
   PubMed Web of Science ®Google Scholar
• Ahima RS, Antwi DA. Brain regulation of appetite and satiety. Endocrinol Metab Clin North Am. 2008;37(4):811–823.
   PubMed Web of Science ®Google Scholar
• Broberger C. Brain regulation of food intake and appetite: molecules and networks. J Gen Intern Med. 2005;258(4):301–327.
   Google Scholar
• Elias CF, Aschkenasi C, Lee C, et al. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron. 1999;23(4):775–786. .
   PubMed Web of Science ®Google Scholar
• Cowley MA, Smart JL, Rubinstein M, et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature. 2001;411(6836):480–484. .
   PubMed Web of Science ®Google Scholar
• Woods S, Seeley R. Understanding the physiology of obesity: review of recent developments in obesity research. Int J Obes. 2002;26(S4):S8–S10.
   Google Scholar
• Kopp W. How western diet and lifestyle drive the pandemic of obesity and civilization diseases. Diabetes Metab Syndr Obes. 2019;12:2221–2236.
   PubMed Web of Science ®Google Scholar
• Kim GW, Lin JE, Blomain ES, et al. Anti-Obesity pharmacotherapy: new drugs and emerging Targets. Clin Pharm Therap. 2014;95(1):53–66.
   Google Scholar
• Woon ECY, Toh JDW. Antiobesity Effects of Natural Products from an Epigenetic Perspective. In: Atta ur R, editor. Studies in Natural Products Chemistry. Vol. 41. Elsevier:  Amsterdam, Netherlands; 2014. p. 161–193.
   Google Scholar
• Mukherjee M. Human digestive and metabolic lipases - A brief review. J Mol Cataly B: Enzym. 2003;22(5):369–376.
   Google Scholar
• Ghishan FK, Moran JR, Durie PR, et al. Isolated congenital lipase—colipase deficiency. Gastroenterology. 1984;86(6):1580–1582. .
   PubMed Web of Science ®Google Scholar
• Resende PE, Verza SG, Kaiser S, et al. The activity of mate saponins (Ilex paraguariensis) in intra-abdominal and epididymal fat, and glucose oxidation in male Wistar rats. J Ethnopharmacol. 2012;144(3):735–740. .
   PubMed Web of Science ®Google Scholar
• Barbier P, Schneider F. Syntheses of tetrahydrolipstatin and absolute configuration of tetrahydrolipstatin and lipstatin. Helv Chim Acta. 1987;70(1):196–202.
   Web of Science ®Google Scholar
• Bailly J, Martin E, Raab S, et al., inventors; Hoffmann La Roche Inc, assignee. Antiobesity composition. United States patent US7816342B2. 2010 Oct 19.
   Google Scholar
• Ikemoto A, Sakamoto K, inventors; Akita Univ, Sakamoto Bio, assignee. Composition for preventing and improving hyperlipemia and obesity. Japan patent JP2010265182A. 2010 Nov 25.
   Google Scholar
• Faisal M, Nishida H, inventors; Bioactives Japan K.K., assignee. Composition and method for the safe and effective inhibition of pancreatic lipase in mammals. World patent WO2013150771A1. 2013 Oct 10.
   Google Scholar
• Kamada Y, Toyokawa T, Teruya S, et al., inventors; Okinawa Prefecture, assignee. Lipase inhibitor. Japan patent JP5309292B2. 2013 Oct 9.
   Google Scholar
• Smith CA, inventor; Conrad Anton Smith, assignee. Composition for obesity treatment. United States patent US8420131B2. 2013 Apr 16.
   Google Scholar
• Kim JS, Jang DS, Kim YS, et al., inventors; Korea Institute of Oriental Medicine KIOM, assignee. Compositions and functional foods for treating and preventing obesity using Polygonum cuspidatum butanol fraction and ethyl acetate fraction. United States patent US9504725B2. 2012 Nov 29.
   Google Scholar
• Fang L, Jianfu S, Liuqing D, inventors; Zhejiang Yunqi Longxiang Biotechnology Co., Ltd., assignee. Purposes of the perfume Flos Nelumbinis extract and combinations thereof in terms of pre- preventing obesity, improvement gut flora. China patent CN106962933A. 2017 Jul 21.
   Google Scholar
• Noh S, Mirae S, inventors; Daegu Haany University Industry-Academic Cooperation Foundation, assignee. Preparation method of anti-obesity composition using Diospyros kaki thunb and Citrus unshiu peel. Korea patent KR20180039418A. 2018 Apr 18.
   Google Scholar
• Hasani-Ranjbar S, Jouyandeh Z, Abdollahi M. A systematic review of anti-obesity medicinal plants - an update. J Diabetes Metab Disord. 2013;12(1):28.
   PubMedGoogle Scholar
• Rayalam S, Della-Fera MA, Baile CA. Phytochemicals and regulation of the adipocyte life cycle. J Nutr Biochem. 2008;19(11):717–726.
   PubMed Web of Science ®Google Scholar
• Gokaraju G, Gokaraju R, Golakoti T, et al., inventors; Laila Nutraceuticals, assignee. Anti-obese compositions containing Holoptelea integrifolia extracts. United States patent US20100203078A1. 2010 Dec 8.
   Google Scholar
• Gokaraju G, Gokaraju R, Gokaraju V, et al., inventors; Laila Nutraceuticals, assignee. Agents derived from Holoptelea integrifolia and their compositions for the control of metabolic syndrome and associated diseases. United States patent US 9345732B2. 2016 May 24.
   Google Scholar
• Kim SK, Kim SW, Lee SC, et al., inventors; Konkuk University Industry-Academic Cooperation Foundation, assignee. A pharmaceutical composition comprising cordycepin for the treatment and prevention of obesity. Korea patent KR100799116B1. 2010.
   Google Scholar
• Kim JD, inventor; Chonnam National University Industry Foundation assignee. Anti-angiogenic agents and anti-obesity substances applied with anti-angiogenesis from natural products. United Staes patent US 20100247691 A1. 2010 Sep 30.
   Google Scholar
• Lee HS, Zee OP, Oh JS, et al., inventors; Lee Hai Soo, assignee. Composition for treatment of obesity using wheat bran extract or active ingredient isolated therefrom. United States patent US20130102554A1. 2013 Feb 8.
   Google Scholar
• Liu IM, Chang CJ, Liou SS, inventors; Han Sheng Pharmtech Inc, assignee. Ginger extract for inhibiting the fat-storage function of adipocytes and a medication thereof. United States patent US8501249B2. 2013 Aug 6.
   Google Scholar
• Lee KW, Seok SJ, inventors; Seoul National University R&DB Foundation, assignee. Food composition for preventing obesity, pharmaceutical composition for treating obesity, and animal medicine for treating obesity, containing gingernone A. United States patent US20140371326A1. 2014.
   Google Scholar
• Chul K, Ree S, Hyup L, inventors; Kangwon National University Industry-Academic Cooperation Foundation, assignee. Cubic phase nanoparticle and herbal extracts mixture suspension exhibiting enhanced anti-obesity efficacy and method for preparing same. Korean patent KR101302154 (B1). 2013 Aug 30.
   Google Scholar
• Ramazanov Z, inventor; Nektium Pharma Sl, assignee. Composition for treating obesity and method of using the same. United States patent US20140037678A1. 2014 Feb 6.
   Google Scholar
• Gokaraju G, Gokaraju R, Gokaraju V, et al., inventors; Laila Nutraceuticals, assignee. A composition comprising extract of Alangium salvifolium having anti-adipogenic or anti-obesic activity. World patent WO2015198346. 2015 Dec 30.
   Google Scholar
• Bojanowska E, Ciosek J. Can we selectively reduce appetite for energy-dense foods? An overview of pharmacological strategies for modification of food preference behavior. Curr Neuropharmacol. 2016;14(2):118–142.
   PubMed Web of Science ®Google Scholar
• Foll B, Strat Y, inventors; Bernard Le Foll, Yann Le Strat, assignee. Use of marihuana and compounds therein for treating obesity. World patent WO2012083414A1. 2012 Jun 28.
   Google Scholar
• Wagner H, Ulrich-Merzenich G. Synergy research: approaching a new generation of phytopharmaceuticals. Phytomedicine. 2009;16(2–3):97–110.
   PubMed Web of Science ®Google Scholar
• Yamashita A, Takashita T, inventors; BNH Co. Ltd., assignee. Obesity inhibitor. Japan patent JP4432069B2. 2010 Mar 17.
   Google Scholar
• Samuel P, Pescatore F, inventors; InqPharma Group, assignee. Herbal composition for weight management. United States patent US8563051B2. 2013 Oct 22.
   Google Scholar
• Chunhua G, inventor; Gou Chunhu, assignee. Lycium ruthenicum slimming tablet (tea). China patent CN104757535A. 2015 Jul 8.
   Google Scholar
• Sybille BW, Karin BB, inventors; Vital Solutions Swiss AG, assignee. Mangifera indica as a sirtuin 1 activating agent. United States patent US20170042957A1. 2017 Feb 16.
   Google Scholar
• Hyun L, Joo KE, Jeong YH, et al., inventors; Dain Bio Co., Ltd, assignee. Fermented persimmon leaves, fermented persimmon leaves extract and use there of. Korea patent KR101745597B1. 2017 Jun 12.
   Google Scholar
• Crystal K, Leiguo M, Yani W, et al., inventors; Dongguan Natural Balance Health Technology Co., Ltd., assignee. A kind of Chinese medicine compound prescription slimming health food and preparation method thereof. China patent CN106728464A. 2017 May 31.
   Google Scholar
• Vadimovich KB, Vladimorovih GB, inventors; Via Vita Estate Limited, assignee. Means for prevention and treatment of type 2 diabetes, metabolic syndrome. Russia patent RU2623872C1. 2017 Jun 29.
   Google Scholar
• Gokaraju G, Gokaraju R, Golakoti T, et al., inventors; Laila Nutraceurticals assignee. Synergistic phytochemical composition for the treatment of obesity. United States patent US8541383. 2013 Sep 24.
   Google Scholar
• Chang-gyu S, Huengchan SL, et al., inventors; Daejeon University Industry-Academia Collaboration Foundation, assignee. Composition containing extracts of Artemisia iwayomogi and Curcuma longa as active ingredients for preventing, inhibiting, or treating obesity-related diseases. Korea patent WO2014133286A1. 2013 Sep 4.
   Google Scholar
• Kim MY, Lee HS, Kim JS, et al., inventors; AngioLab Inc, assignee. Antiobesity composition. United States patent US 9155773B2 2015 Mar 13.
   Google Scholar
• Zhari BI, Khalid H, inventors; Universiti Sains Malaysia, assignee. A herbal composition having anti-obesity property. World patent WO2011112067A1. 2011 Sep 15.
   Google Scholar
• Shaozheng W, inventor; Wu Shaozheng, assignee. Lotus leaf and hawthorn health-preserving herbal tea beverage and preparation method thereof. China patent CN104304540A. 2014 Jan 28.
   Google Scholar
• Park D, Chang Y, Kim K, et al., inventors; Dong Wha Pharm Co. Ltd, assignee. Compositions comprising an extract of Piper longum l. for preventing, treating and improving voiding dysfunction. Japan patent JP2019014761A. 2019 Jan 31.
   Google Scholar
• Gye-man J, Ahn M, Eun H, et al., inventors; Gyeongnam National University of Science and Technology, assignee. Beverage of bitter melon and fruit-vegetable mixture with excellent palatability and high GABA and high functionality fermented by Lactobacillus plantarum and Lactobacillus brevis. Korea patent KR20180132208A. 2018 May 2.
   Google Scholar
• Kim H, Hong S, Yu J, inventors; Jinis Co Ltd, assignee. Strain having ability to inhibit obesity and pharmaceutical composition containing same. United States patent US20200061132A1. 2020 Feb 27.
   Google Scholar
• Dunlop J, Rosenzweig-Lipson S. Therapeutic approaches to obesity. Expert Opin Ther Pat. 1998;8(12):1683–1694.
   Web of Science ®Google Scholar
• Minsheng L, inventor; Anhui Lipton Biological Pharmaceutical Co., Ltd., assignee. Bagged lotus-leaf slimming tea. China patent CN102318697A. 2012 Jan 18.
   Google Scholar
• Junping X, Yongzhong W, Weiqing Y, et al., inventors; Puzheng Pharmaceutical Co., Ltd., assignee. Eucommia ulmoides composition with antiobesity effect and preparation of Eucommia ulmoides composition. China patent CN104435068A. 2016 Jan 13.
   Google Scholar
• Leal DAM, Gutierrez UJA, Torres YTN, et al., inventors; Monterrey Institute of Technology and Higher Studies, National Institute of Medical Sciences and Nutrition Salvador Zubirán, assignee. Agavaceae extract comprising steroidal saponins to treat or prevent metabolic disorder related pathologies. World patent WO2017064530A1. 2017 Apr 20.
   Google Scholar
• Kim T, Kim T, inventors; Daegu University Industry-Academic Cooperation Foundation, assignee. Composition for anti-obesity comprising novel compound isolated from Ainsliaea acerifolia extract as effective component. Korea patent KR1020160099136A. 2018 Sep 19.
   Google Scholar
• Singh IP, Ahmad F, Gore DD, et al. Therapeutic potential of seabuckthorn: a patent review (2000-2018). Expert Opin Ther Pat. 2019;29(9):733–744.
   PubMed Web of Science ®Google Scholar
• Gondoin A, Grussu D, Stewart D, et al. White and green tea polyphenols inhibit pancreatic lipase in vitro. Food Res Int. 2010;43(5):1537–1544. .
   Web of Science ®Google Scholar
• Krishnan GG, inventor; Innoveda Biological Solutions (P) Ltd, assignee. Herbal formulation for prevention and treatment of diabetes and associated complications. United States patent US8163312B2. 2012 April 24.
   Google Scholar