226
Views
2
CrossRef citations to date
0
Altmetric
Review

Iron oxide nanoparticles for biomedical applications: an updated patent review (2015–2021)

, , &
Pages 939-952 | Received 02 Feb 2022, Accepted 01 Aug 2022, Published online: 09 Aug 2022

References

  • Dulinska-Litewka J, Lazarczyk A, Halubiec P, et al. Superparamagnetic iron oxide nanoparticles-current and prospective medical applications. Materials (Basel). 2019;12(4):617.
  • Martinkova P, Brtnicky M, Kynicky J, et al. Iron oxide nanoparticles: innovative tool in cancer diagnosis and Therapy. Adv Healthc Mater. 2018;7(5):1700932.
  • Nabavinia M, Beltran-Huarac J. Recent progress in iron oxide nanoparticles as therapeutic magnetic agents for cancer treatment and tissue engineering. ACS Appl Bio Mater. 2020;3(12):8172–8187.
  • Alphandery E. Iron oxide nanoparticles for therapeutic applications. Drug Discov Today. 2020;25(1):141–149.
  • Dadfar SM, Roemhild K, Drude NI, et al. Iron oxide nanoparticles: diagnostic, therapeutic and theranostic applications. Adv Drug Deliv Rev. 2019;138:302–325.
  • Ali A, Zafar H, Zia M, et al. Synthesis, characterization, applications, and challenges of iron oxide nanoparticles. Nanotechnol Sci Appl. 2016;9:49–67.
  • Yen SK, Padmanabhan P, Selvan ST. Multifunctional iron oxide nanoparticles for diagnostics, therapy and macromolecule delivery. Theranostics. 2013;3(12):986–1003.
  • Alphandéry E. Iron oxide nanoparticles as multimodal imaging tools. RSC Adv. 2019;9(69):40577–40587.
  • Shi J, Kantoff PW, Wooster R, et al. Cancer nanomedicine: progress, challenges and opportunities. Nat Rev Cancer. 2017;17(1):20–37.
  • Mahmoudi M, Sant S, Wang B, et al. Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy. Adv Drug Deliv Rev. 2011;63(1–2):24–46.
  • Rosen JE, Chan L, Shieh DB, et al. Iron oxide nanoparticles for targeted cancer imaging and diagnostics. Nanomedicine. 2012;8(3):275–290.
  • Xie L, Jin W, Chen H, et al. Superparamagnetic iron oxide nanoparticles for cancer diagnosis and therapy. J Biomed Nanotechnol. 2019;15(2):215–416.
  • El-Hammadi MM, Arias JL. Iron oxide-based multifunctional nanoparticulate systems for biomedical applications: a patent review (2008-present). Expert Opin Ther Pat. 2015;25(6):691–709.
  • Shen M, Hu Y, Li J, et al. inventor; Nat Univ Dong Hwa, assignee. Preparation method of RGD-modified subminiature superparamagnetic iron oxide nanoparticles. China patent CN104399092A. 2015 Mar 11.
  • Shi X, Zhu J, Sun W, et al. inventor; Nat Univ Dong Hwa, Shanghai 10th Peoples Hospital, assignee. Preparation and application of iron oxide nanoparticle-loaded gamma-polyglutamic acid hydrogel. China patent CN104740656A. 2015 Jul 1.
  • Shi X, Yu Z, Luo Y, et al. inventor; Nat Univ Dong Hwa, assignee. Preparation method of polyglutamic acid PGA-coated superparamagnetic iron oxide nanoparticle. China patent CN104548145A. 2015 Apr 29.
  • Zhang Y, Jia Z, Xie J, et al. inventor; Univ Southeast, assignee. Preparation method and application of RGD-modified ultra-small magnetic iron oxide nanoparticles. China patent CN104258425A. 2015 Jan 7.
  • Xiao W, Huang Q, Wen S, et al. inventor; Univ Zhejiang, assignee. Super-paramagnetic iron oxide nanoparticle compound as well as preparation method and application thereof. China patent CN105412951A. 2016 Mar 23.
  • Gao J, Chen X, Zhao Z, inventor; US Health, Univ Xiamen, assignee. Octapod iron oxide nanoparticles as high-performance T2 contrast agents for magnetic resonance imaging. United States patent US2016129138A1. 2016 May 12.
  • Liu G, Zhang B, Liu L, et al. inventor; Univ Jilin, assignee. T1/T2 dual relaxation platinum-iron oxide-gold nanoparticle and preparation method. China patent CN107375952A. 2017 Nov 24.
  • Torsten H, Matthew W, Donald WM, inventor; Univ Kent State Ohio, assignee. Aqueous synthesis of polyhedral “brick-like” iron oxide nanoparticles for hyperthermia and T2 MRI contrast enhancement, and for targeting endothelial cells for therapeutic delivery. United States patent US2018297857A1. 2018 Oct 18.
  • Ling D, Li F, Liang Z, inventor; Univ Zhejiang, assignee. Preparation method of pH-responsive ultra-small iron oxide nanoparticle assembly, product thereof, and application of product. China patent CN108543082A. 2018 Sep 18.
  • Yi P, Wang H, Yang X, inventor; Suzhou Inst Biomedical Eng & Tech Cas, assignee. Preparation method of iron oxide nanoparticle compound, compound and high-resolution cerebral blood volume MRI imaging method. China patent CN110665019A. 2020 Jan 10.
  • Yi P, Wang H, Yang X, inventor; Suzhou Inst Biomedical Eng & Tech Cas, assignee. Preparation method of ultra-small-size iron oxide nanoparticles and application thereof. China patent CN110680931A. 2020 Jan 14.
  • Rabanal H, Barahona F, inventor; Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.), assignee. Iron oxide nanoparticles doped with cooper. Europe patent EP3646889A1. 2020 May 6.
  • Artemovich AM, Georgievich MA, inventor; National Univ of Science and Tech Misis, assignee. Method of fabrication of preparation on the base of iron oxide magnetic nanoparticles for neoplasms diagnostics by magnetic resonance imaging. World patent WO2019093923A1. 2019 May 16.
  • Zhou C, Sun T, Liu Y, et al. inventor; 2nd AF Hosp Army Medical Univ, Univ Southwest Petroleum, assignee. Fluorine-doped iron oxide nanoparticle contrast agent and preparation method thereof. China patent CN112656958A. 2021 Apr 16.
  • Fan H, Miao Y, Zhang H, et al. inventor; Xian Supermag Nano Biotechnology Co., Ltd., assignee. Ultra-small iron oxide nanoparticle as well as preparation method and application thereof. China patent CN112299489A. 2021 Feb 2.
  • Lee YS, Hyeon TH, Jeong JM, et al. inventor; Therabest Co., Ltd., assignee. Ultrafine iron oxide nanoparticle-based magnetic resonance imaging T1 contrast agent. Europe patent EP3922271A1. 2021 Dec 15.
  • Pedro S, inventor; Uti LP, assignee. Methods and compositions for sustained immunotherapy. Canadian patent CA2929700A1. 2015 May 7.
  • Mao H, Huang J, inventor; Univ Emory, assignee. Casein coated drug-loaded iron oxide nanoparticles. United States patent US2017333366A1. 2017 Nov 23.
  • Kaittanis C, Grimm J, inventor; Memorial Sloan Kettering Cancer Center, assignee. Delivery of therapeutic compounds with iron oxide nanoparticles. United States patent US2019388542A1. 2019 Dec 26.
  • Pedro S, inventor; Uti LP, assignee. Methods of treating autoimmune disease. World patent WO2019106435. 2019 Jun 6.
  • Benjamin S, Mohammed S, Sanjay S, inventor; Lipid coated iron oxide nanoparticles for otitis media. World patent WO2021081251A1. 2021 Apr 29.
  • Jesse J, Henry LW, George MR, et al. inventor; Riptide Bioscience Inc, assignee. Peptides having immunomodulatory properties. China patent CN113039194A. 2021 Jun 25.
  • Lee D-Y, Jang S-B, Lee S-J, inventor; Univ Hanyang Ind Univ Coop Found, assignee. Glycyrrhizin-glycol chitosan conjugate-coated iron oxide nanoparticles and use thereof. China patent CN112367977A. 2021 Feb 12.
  • Chen C-Y, Ali AA, Hsu F-T, et al. inventor; Sagabio Co., Ltd., assignee. Dextran-magnetic iron oxide nanoparticle, preparation and use in treating cancer and as contrast. World patent WO2018098705A1. 2018 Jun 7.
  • Xiong F, Shan X, Gu N, et al. inventor; Zhenjiang First Peoples Hospital, assignee. Preparation method of novel iron-oxide nanoparticle and application of nanoparticle to tumor targeted diagnosis and treatment. China patent CN109125742A. 2019 Jan 4.
  • Chen Y, Huang K, Zuo J, et al. inventor; Sun Yat Sen Memorial Hospital Sun Yat Sen Univ, Chen Y, Huang K, et al., assignee. Iron oxide nanoparticle compound and preparation method and application thereof. China patent CN110841072A. 2020 Feb 28.
  • Bae ST, Jang JT, inventor; Neo Nanomedics Inc., assignee. Iron oxide nanoparticles doped with alkali metals or alkali earth metals capable of gigantic magnetic self-heating in biocompatible AC magnetic field and method of preparing the same. United States patent US2019023584A1. 2019 Jan 24.
  • Ivkov R, inventor; Univ Johns Hopkins, assignee. Process for making iron oxide nanoparticle preparations for cancer hyperthermia. United States patent US2020155682A1. 2020 May 21.
  • Shieh D-B, Tsai P-J, Lee W-T, inventor; Shieh DB, assignee. Use of iron oxide nanoparticle in inhibiting spore germination of clostridium difficile. China patent CN107041125A. 2017 Aug 11.
  • Zhao Y, Zhu L, inventor ZYP, et al. assignee. Preparation method of copper-iron oxide and mixed nanoparticles and antibacterial application. China patent CN110074136A. 2019 Aug 2.
  • Ling D, Yang Y, Chen Z, et al. inventor; Univ Zhejiang, assignee. Application of iron oxide nanoparticles in inhibiting monocyte activation. China patent CN109908171A. 2019 Jun 21.
  • Xiong F, Sun Y, Zhang Y, et al. inventor; Univ Southeast, assignee. Application of poloxamer-modified iron oxide nanoparticles in preparation of medicines for treatment of non-alcoholic fatty liver disease. China patent CN109224083A. 2019 Jan 18.
  • Daldrup-Link HE, inventor; Univ Leland Stanford Junior, assignee. Immuno-therapy for cancer treatment using iron oxide nanoparticles. United States patent US2017360965A1. 2017 Dec 21.
  • Jeon BS, Kwon EB, Kim EG, et al. inventor; Hanwha Chemical Corp, assignee. Pharmaceutical composition for preventing or treating iron deficiency, comprising iron oxide nanoparticles. World patent WO2015102289A1. 2015 Jul 9.
  • Chen C-L, Hsieh W-Y, Lin C-H, inventor; Ind Tech Res Inst, assignee. Method of treating iron deficiency. United States patent US2016008292A1. 2016 Jan 14.
  • Sun J, Li N, Lu Q, et al. inventor; Univ Southeast, assignee. Application of superparamagnetic iron oxide nanoparticles in preparation of nerve magnetic stimulation enhancers for treating neurogenic diseases. China patent CN108853057A. 2018 Nov 23.
  • Tang J, Zheng M, Yu F, et al. inventor; Second Xiangya Hospital of Central South University, assignee. Applications of iron oxide nanoparticles in preparation of drug for improving erlotinib resistance. China patent CN105055447A. 2015 Nov 18.
  • Matthew FR, Praful KA, Jeffrey KS, et al. inventor; Lodespin Labs, Llc, assignee. The use of iron oxide nanoparticles in magnetically guided sentinel lymph node biopsy. World patent WO2016154552A1. 2016 Sep 29.
  • Zhang B, Nie W, Su L, et al. inventor; Univ Guilin Technology, assignee. Preparation method for chondroitin sulfate modified iron-oxide nanoparticles capable of distributing in intercellular space of brains. China patent CN110201179A. 2019 Sep 6.
  • Shen Y, Hu F, Huang Z, inventor; Shanghai East Hospital Tongji Univ Affiliated East Hospital, assignee. Anti-oxidative magnetic iron oxide nanoparticles and preparation method thereof. China patent CN109758581A. 2019 May 17.
  • Caspani S, Magalhaes R, Araujo JP, et al. Magnetic nanomaterials as contrast agents for MRI. Materials (Basel). 2020;13(11): 2586.
  • Na HB, Song IC, Hyeon T. Inorganic nanoparticles for MRI contrast agents. Adv Mater. 2009;21(21):2133–2148.
  • Avasthi A, Caro C, Pozo-Torres E, et al. Magnetic nanoparticles as MRI contrast agents. Top Curr Chem (Cham). 2020;378(3):40.
  • Neto DMA, da Costa LS, de Menezes FL, et al. A novel amino phosphonate-coated magnetic nanoparticle as MRI contrast agent. Appl Surf Sci. 2021;543:148824.
  • Zhao Z, Zhou Z, Bao J, et al. Octapod iron oxide nanoparticles as high-performance T2 contrast agents for magnetic resonance imaging. Nat Commun. 2013;4(1):2266.
  • Zhou Z, Yang L, Gao J, et al. Structure-relaxivity relationships of magnetic nanoparticles for magnetic resonance imaging. Adv Mater. 2019;31(8):e1804567.
  • Marcus M, Karni M, Baranes K, et al. Iron oxide nanoparticles for neuronal cell applications: uptake study and magnetic manipulations. J Nanobiotechnology. 2016;14(1):37.
  • Uzhytchak M, Lynnyk A, Zablotskii V, et al. The use of pulsed magnetic fields to increase the uptake of iron oxide nanoparticles by living cells. Appl Phys Lett. 2017;111(24):243703.
  • Huang J, Shu Q, Wang L, et al. Layer-by-layer assembled milk protein coated magnetic nanoparticle enabled oral drug delivery with high stability in stomach and enzyme-responsive release in small intestine. Biomaterials. 2015;39:105–113.
  • Zhang T, Xu Q, Huang T, et al. New insights into biocompatible iron oxide nanoparticles: a potential booster of gene delivery to stem cells. Small. 2020;16(37):e2001588.
  • Kelkar SS, Reineke TM. Theranostics: combining imaging and therapy. Bioconjug Chem. 2011;22(10):1879–1903.
  • Xiong F, Hu K, Yu H, et al. A functional iron oxide nanoparticles modified with PLA-PEG-DG as tumor-targeted MRI contrast agent. Pharm Res. 2017;34(8):1683–1692.
  • Li J, Chen Y, Zeng L, et al. A nanoparticle carrier for co-delivery of gemcitabine and small interfering RNA in pancreatic cancer therapy. J Biomed Nanotechnol. 2016;12(8):1654–1666.
  • Das P, Colombo M, Prosperi D. Recent advances in magnetic fluid hyperthermia for cancer therapy. Colloids Surf B Biointerfaces. 2019;174:42–55.
  • Myrovali E, Maniotis N, Samaras T, et al. Spatial focusing of magnetic particle hyperthermia. Nanoscale Adv. 2020;2(1):408–416.
  • Lanier OL, Korotych OI, Monsalve AG, et al. Evaluation of magnetic nanoparticles for magnetic fluid hyperthermia. Int J Hyperthermia. 2019;36(1):687–701.
  • Slavin YN, Asnis J, Hafeli UO, et al. Metal nanoparticles: understanding the mechanisms behind antibacterial activity. J Nanobiotechnology. 2017;15(1):65.
  • Stankic S, Suman S, Haque F, et al. Pure and multi metal oxide nanoparticles: synthesis, antibacterial and cytotoxic properties. J Nanobiotechnology. 2016;14(1):73.
  • Alavi M, Rai M. Recent advances in antibacterial applications of metal nanoparticles (MNPs) and metal nanocomposites (MNCs) against multidrug-resistant (MDR) bacteria. Expert Rev Anti Infect Ther. 2019;17(6):419–428.
  • Morteza M, Ali SM, inventor; Morteza M, Ali SM. Pasteur inst of Iran, assignee. Super paramagnetic iron oxide nanoparticles with metallic coatings and a method of synthesizing the same. United States patent US2014234429A1. 2014 Aug 21.
  • Munn LL. Cancer and inflammation. Wiley Interdiscip Rev Syst Biol Med. 2017;9(2):e1370.
  • Yang L, Xie X, Tu Z, et al. The signal pathways and treatment of cytokine storm in COVID-19. Signal Transduct Target Ther. 2021;6(1):255.
  • Grosse S, Stenvik J, Nilsen AM. Iron oxide nanoparticles modulate lipopolysaccharide-induced inflammatory responses in primary human monocytes. Int J Nanomedicine. 2016;11:4625–4642.
  • Wang XJ, Malhi H. Nonalcoholic fatty liver disease. Ann Intern Med. 2018;169(9):ITC65–80.
  • Cheung A, Figueredo C, Rinella ME. Nonalcoholic fatty liver disease: identification and management of high-risk patients. Am J Gastroenterol. 2019;114(4):579–590.
  • Sun Y, Shi F, Niu Y, et al. Fe3O4@OA@poloxamer nanoparticles lower triglyceride in hepatocytes through liposuction effect and nano-enzyme effect. Colloids Surf B Biointerfaces. 2019;184:110528.
  • Weber EW, Maus MV, Mackall CL. The emerging landscape of immune cell therapies. Cell. 2020;181(1):46–62.
  • Dougan M, Dranoff G. Immune therapy for cancer. Annu Rev Immunol. 2009;27(1):83–117.
  • Soetaert F, Korangath P, Serantes D, et al. Cancer therapy with iron oxide nanoparticles: agents of thermal and immune therapies. Adv Drug Deliv Rev. 2020;163-164:65–83.
  • Zanganeh S, Hutter G, Spitler R, et al. Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues. Nat Nanotechnol. 2016;11(11):986–994.
  • Pasricha S-R, Tye-Din J, Muckenthaler MU, et al. Iron deficiency. Lancet. 2021;397(10270):233–248.
  • Camaschella C. New insights into iron deficiency and iron deficiency anemia. Blood Rev. 2017;31(4):225–233.
  • Wisniewski T, Turnbull D, Sigurdsson E, et al. inventor; Univ New York,assignee. Detection of Alzheimer’s amyloid by magnetic resonance imaging. United States Patent US2003147811A1. 2003 Aug 7.
  • Singh N, Jenkins GJ, Asadi R, et al. Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION). Nano Rev. 2010;1(1):5358.
  • Qiu H, Wang P, Zhang M. A patent review of m-TOR inhibitors for cancer therapy (2011-2020). Expert Opin Ther Pat. 2021;31(11):965–975.
  • Mansoori B, Mohammadi A, Davudian S, et al. The different mechanisms of cancer drug resistance: a brief review. Adv Pharm Bull. 2017;7(3):339–348.
  • Wang P, Qiu H, He Y, et al. Cyclin-dependent kinase 4/6 inhibitors for cancer therapy: a patent review (2015-2019). Expert Opin Ther Pat. 2020;30(10):795–805.
  • Zhang M, Sai B, Cao P, et al. iron oxide nanoparticles synergize with erlotinib to suppress refractory non-small cell lung cancer cell proliferation through the inhibition of ErbB/PI3K/AKT and PTEN activation. J Biomed Nanotechnol. 2017;13(4):458–468.
  • Kobayashi S, Ohki A, Tanoue M, et al. Comparative study of extracellular and intracellular magnetic hyperthermia treatments using magnetic particle imaging. Open J Appl Sci. 2017;7(12):647–660.
  • Pan J, Hu P, Guo Y, et al. Combined magnetic hyperthermia and immune therapy for primary and metastatic tumor treatments. ACS Nano. 2020;14(1):1033–1044.
  • Chen Z, Yin -J-J, Zhou Y-T, et al. Dual enzyme-like activities of iron oxide nanoparticles and their implication for diminishing cytotoxicity. ACS nano. 2012;6(5):4001–4012.
  • Escelsior A, Sterlini B, Murri MB, et al. Red-hot chili receptors: a systematic review of TRPV1 antagonism in animal models of psychiatric disorders and addiction. Behav Brain Res. 2020;393:112734.
  • Stanley SA, Sauer J, Kane RS, et al. Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticles. Nat Med. 2015;21(1):92–98.
  • Zheng H, You J, Yao X, et al. Superparamagnetic iron oxide nanoparticles promote ferroptosis of ischemic cardiomyocytes. J Cell Mol Med. 2020;24(18):11030–11033.
  • Abo-zeid Y, Ismail NSM, McLean GR, et al. A molecular docking study repurposes FDA approved iron oxide nanoparticles to treat and control COVID-19 infection. Eur J Pharm Sci. 2020;153:105465.
  • Dubreil C, Sainte CO, Lalatonne Y, et al. Tolerogenic iron oxide nanoparticles in type 1 diabetes: biodistribution and pharmacokinetics studies in nonobese diabetic mice. Small. 2018;14(40):e1802053.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.