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Research Article

New ultrasensitive 32P-postlabelling method for the analysis of 3,N4-etheno-2′-deoxycytidine in human urine

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Pages 329-340 | Received 17 Jan 2006, Published online: 08 Oct 2008

References

  • Bartsch H, Nair J. Accumulation of lipid peroxidation-derived DNA lesions: potential lead markers for chemoprevention of inflammation-derived malignancies. Mutation Research 2005; 591: 34–44
  • Chen HJ, Chang CM. Quantification of urinary excretion of 1,N6-ethenoadenine, a potential biomarker of lipid peroxidation, in humans by stable isotope dilution, liquid chromatography-electrospray ionization-tandem mass spectrometry: comparison with gas chromatography-mass spectrometry. Chemical Research in Toxicology 2004; 17: 963–971
  • Chen HJ, Lin TC, Hong CL, Chiang LC. Analysis of 3,N4-ethenocytosine in DNA and in human urine by isotope dilution gas chromatography/negative ion chemical ionization/mass spectrometry. Chemical Research in Toxicology 2001; 14: 1612–1619
  • Chen HJ, Wu CF, Hong CL, Chang CM. Urinary excretion of 3,N4-etheno-2′-deoxycytidine in humans as a biomarker of oxidative stress: association with cigarette smoking. Chemical Research in Toxicology 2004; 17: 896–903
  • Chung F-L, Chen H-J, Nath RG. Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts: a commentary. Carcinogenesis 1996; 17: 2105–2111
  • Cooke MS, Evans MD, Herbert LJ, Lunec J. Urinary 8-oxo-2′-deoxyguanosine-source, significance and supplements. Free Radical Research 2000; 32: 381–397
  • El Ghissassi F, Barbin A, Nair J, Bartsch H. Formation of 1,N6-ethenoadenosine and 3,N4-ethenocytosine by lipid peroxidation products and nucleic acid bases. Chemical Research in Toxicology 1995; 8: 278–283
  • Fernando RC, Nair J, Barbin A, Miller JA, Bartsch H. Detection of 1,N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytidine by immunoaffinity/32P-postlabeling in liver and lung DNA of mice treated with ethyl carbamate (urethane) or its metabolites. Carcinogenesis 1996; 17: 1711–1718
  • Guengerich FP. Roles of the vinyl chloride oxidation products 1-chloro-oxirane and 2-chloroacetaldehyde in the in vitro formation of etheno adducts of nucleic acid bases. Chemical Research in Toxicology 1992; 5: 2–5
  • Guichard Y, Nair J, Barbin A, Bartsch H. Immunoaffinity clean-up combined with 32P-postlabeling analysis of 1,N6-ethenoadenosine and 3,N4-ethenocytosine in DNA. Postlabeling methods for the detection of DNA adducts. Science Publication Vol. 124, DH Phillips, M Castegnaro, H Bartsch. International Agency for Research on Cancer, Lyon 1993; 263–269
  • Hanaoka T, Nair J, Takahashi Y, Sasaki S, Bartsch H, Tsugane S. Urinary level of 1,N6-ethenodeoxyadenosine, a marker of oxidative stress, is associated with salt excretion and ω-6-polyunsaturated fatty acid intake in postmenopausal Japanese women. International Journal of Cancer 2002; 100: 71–75
  • Hillestrom PR, Hoberg AM, Weimann A, Poulsen HE. Quantification of 1,N6-ethenodeoxyadenosine in human urine by column-switching LC/APCI-MS/MS. Free Radicals in Biology and Medicine 2004; 36: 1383–1392
  • Hoberg AM, Otteneder M, Narnett LJ, Poulsen HE. Measurement of the malondialdehyde-2′-deoxyguanosine adduct in human urine by immuno-extraction and liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry. Journal of Mass Spectrometry 2004; 39: 38–42
  • Hussain SP, Hofseth LJ, Harris CC. Radical causes of cancer. National Reviews in Cancer 2003; 3: 276–285
  • Johansson M, Van Rompay AR, Degreve B, Balzarin J, Karlsson A. Cloning and characterization of the multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster. Journal of Biology and Chemistry 1999; 274: 23814–23819
  • Leithauser MT, Liem A, Stewart BC, Miller EC, Miller JA. 1,N6-ethenoadenosine formation, mutagenicity, and murine tumor induction as indicators of the generation of an electrophilic epoxide metabolite of the closely related carcinogens ethyl carbamate (urethane) and vinyl carbamate. Carcinogenesis 1990; 11: 463–473
  • Nair J. 1999. Lipid peroxidation-induced etheno–DNA adducts in humans. In: Exocylic DNA adducts in mutagenesis and Carcinogenesis. Singer B, Bartsch H, editors. IARC Scientific Publication Vol. 150. Lyon: International Agency for Research on Cancer. p. 55–61.
  • Nair J, Barbin A, Velic I, Bartsch H. Etheno–DNA-base adducts from endogenous reactive species. Mutation Research 1999; 424: 59–69
  • Nair J, Carmichael PL, Fernando RC, Phillips DH, Strain AJ, Bartsch H. Lipid peroxidation-induced etheno–DNA adducts in the liver of patients with the genetic metal storage disorders Wilson's disease and primary hemochromatosis. Cancer Epidemiology Biomarkers Prevention 1998a; 7: 435–440
  • Nair J, Gal A, Tamir S, Tannenbaum SR, Wogan GN, Bartsch H. Etheno adducts in spleen DNA of SJL mice stimulated to overproduce nitric oxide. Carcinogenesis 1998b; 19: 2081–2084
  • Nair J, Gansauge F, Beger H, Dolara P, Winde G, Bartsch H. 2006. Increased etheno–DNA adducts in affected tissues of patients suffering from Crohn's disease, Ulcerative colitis and Chronic Pancreatitis. Antioxidants and Redox Signaling 8:1003–10.
  • Nair J, Vaca CE, Velic I, Mutanen M, Valsta LM, Bartsch H. High dietary ω-6 polyunsaturated fatty acids drastically increase the formation of etheno–DNA base adducts in white blood cells of female subjects. Cancer Epidemiology Biomarkers Prevention 1997; 6: 597–601
  • Sun X, Nair J, Bartsch H. A modified immuno-enriched 32P-postlabeling method for analyzing the malondialdehyde-deoxyguanosine adduct, 3-(2-deoxy-β-D-erythro-pentofuranosyl)-pyrimido [1,2-α]purin-10(3H)one in human tissue samples. Chemical Research in Toxicology 2004; 17: 268–272
  • Swenberg JA, Fedtke N, Ciroussel F, Barbin A, Bartsch H. Etheno adducts formed in DNA of vinyl chloride-exposed rats are highly persistent in liver. Carcinogenesis 1992; 13: 727–729

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