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Review Article

Blood markers of inflammation and endothelial dysfunction in cardioembolic stroke: systematic review and meta-analysis

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Pages 200-209 | Received 22 Aug 2016, Accepted 21 Jan 2017, Published online: 14 Feb 2017

References

  • Alvarez-Perez, F.J., Castelo-Branco, M., and Alvarez-Sabin, J. 2011. Albumin level and stroke. Potential association between lower albumin level and cardioembolic aetiology. Int J Neurosci, 121, 25–32.
  • Aulin, J., et al., 2015. Interleukin-6 and C-reactive protein and risk for death and cardiovascular events in patients with atrial fibrillation. Am Heart J, 170, 1151–1160.
  • Beamer, N.B., et al., 1995. Interleukin-6 and interleukin-1 receptor antagonist in acute stroke. Ann Neurol, 37, 800–805.
  • Beer, C., et al., 2011. Association of clinical and aetiologic subtype of acute ischaemic stroke with inflammation, oxidative stress and vascular function: a cross-sectional observational study. Med Sci Monit, 17, CR467–CR473.
  • Biteker, M., et al., 2015. Aortic stiffness and plasma brain natriuretic peptide predicts mortality in acute ischemic stroke. Int J Stroke, 10, 679–685.
  • Boos, C.J., Anderson, R.A., and Lip, G.Y. 2006. Is atrial fibrillation an inflammatory disorder? Eur Heart J, 27, 136–149.
  • Burn, J., et al., 1994. Long-term risk of recurrent stroke after a first-ever stroke. The Oxfordshire Community Stroke Project. Stroke, 25, 333–337. Erratum in: Stroke 1994;25:1887.
  • Bushnell, C.D., and Goldstein, L.B. 2002. Homocysteine testing in patients with acute ischemic stroke. Neurology, 59, 1541–1546.
  • Bustamante, A., et al., 2014. Prognostic value of blood interleukin-6 in the prediction of functional outcome after stroke: a systematic review and meta-analysis. J Neuroimmunol, 274, 215–224.
  • Cermak, J., et al., 1993. C-reactive protein induces human peripheral blood monocytes to synthesize tissue factor. Blood, 82, 513–520.
  • Cherian, P., et al., 2003. Endothelial and platelet activation in acute ischemic stroke and its etiological subtypes. Stroke, 34, 2132–2137.
  • Cucchiara, B.L., et al., 2009. Lipoprotein-associated phospholipase A2 and C-reactive protein for risk-stratification of patients with TIA. Stroke, 40, 2332–2336.
  • Davis, S.M., and Donnan, G.A. 2012. Clinical practice. Secondary prevention after ischemic stroke or transient ischemic attack. N Engl J Med, 366, 1914–1922.
  • den Hertog, H.M., PAIS investigators., et al., 2009. C-reactive protein in the very early phase of acute ischemic stroke: association with poor outcome and death. J Neurol, 256, 2003–2008.
  • Dewan, K.R., and Rana, P.V. 2011. C-reactive protein and early mortality in acute ischemic stroke. Kathmandu Univ Med J (KUMJ), 9, 252–255.
  • Eikelboom, J.W., et al., 2003. C-reactive protein in ischemic stroke and its etiologic subtypes. J Stroke Cerebrovasc Dis, 12, 74–81.
  • Eikelboom, J.W., et al., 2000. Association between high homocyst(e)ine and ischemic stroke due to large- and small-artery disease but not other etiologic subtypes of ischemic stroke. Stroke, 31, 1069–1075.
  • García-Berrocoso, T., et al., 2013. B-type natriuretic peptides and mortality after stroke. A systematic review and meta-analysis. Neurology, 23, 1976–1985.
  • Gray, L.J., Virtual International Stroke Trials Archive Collaboration., et al. 2009. Interconversion of the National Institutes of Health Stroke Scale and Scandinavian Stroke Scale in acute stroke. J Stroke Cerebrovasc Dis, 18, 466–468.
  • Guo, Y., Lip, G.Y., and Apostolakis, S. 2012. Inflammation in atrial fibrillation. J Am Coll Cardiol, 60, 2263–2270.
  • Haapaniemi, E., et al., 2007. Serial measurements of plasma homocysteine levels in early and late phases of ischemic stroke. Eur J Neurol, 14, 12–17.
  • Hanson, E., et al., 2011. Plasma levels of von Willebrand factor in the etiologic subtypes of ischemic stroke. J Thromb Haemost, 9, 275–281.
  • Hardie, K., et al., 2005. Trends in five-year survival and risk of recurrent stroke after first-ever stroke in the Perth Community Stroke Study. Cerebrovasc Dis, 19, 179–185.
  • Hart, R.G., Cryptogenic Stroke/ESUS International Working Group., et al. 2014. Embolic strokes of undetermined source: the case for a new clinical construct. Lancet Neurol, 13, 429–438.
  • Hijazi, Z., on behalf of the ARISTOTLE., et al., 2016. Biomarkers of inflammation and risk of cardiovascular events in anticoagulated patients with atrial fibrillation. Heart, 102, 508–517.
  • Hijazi, Z., et al., 2013. Biomarkers in atrial fibrillation: a clinical review. Eur Heart J, 34, 1475–1480.
  • Hu, Y.F., et al., 2015. Inflammation and the pathogenesis of atrial fibrillation. Nat Rev Cardiol, 12, 230–243.
  • Khan, U., et al., 2008. Homocysteine and its relationship to stroke subtypes in a UK black population: the south London ethnicity and stroke study. Stroke, 39, 2943–2949.
  • Kozuka, K., et al., 2002. Endothelial markers and adhesion molecules in acute ischemic stroke-sequential change and differences in stroke subtype. Atherosclerosis, 161, 161–168.
  • Ladenvall, C., et al., 2006. Serum C-reactive protein concentration and genotype in relation to ischemic stroke subtype. Stroke, 37, 2018–2023.
  • Liberati, A., et al., 2009. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med, 6, e1000100.
  • Licata, G., et al., 2009. Immuno-inflammatory activation in acute cardio-embolic strokes in comparison with other subtypes of ischaemic stroke. Thromb Haemost, 101, 929–937.
  • Lindmark, E., et al., 2001. Relationship between interleukin 6 and mortality in patients with unstable coronary artery disease: effects of an early invasive or noninvasive strategy. JAMA, 286, 2107–2113.
  • Lip, G.Y., et al., 2007. High-sensitivity C-reactive protein and soluble CD40 ligand as indices of inflammation and platelet activation in 880 patients with nonvalvular atrial fibrillation: relationship to stroke risk factors, stroke risk stratification schema, and prognosis. Stroke, 38, 1229–1237.
  • Llombart, V., et al., 2015. B-type natriuretic peptides help in cardioembolic stroke diagnosis: pooled data meta-analysis. Stroke, 46, 1187–1195.
  • Llombart, V., et al., 2013. Cardioembolic stroke diagnosis using blood biomarkers. Curr Cardiol Rev, 9, 340–352.
  • Luo, Y., et al., 2012. Serum CRP concentrations and severity of ischemic stroke subtypes. Can J Neurol Sci, 39, 69–73.
  • Ma, Y., et al., 2010. Homocysteine and ischemic stroke subtype: a relationship study in Chinese patients. Neurol Res, 32, 636–641.
  • Masotti, L., et al., 2005. Prognostic role of C-reactive protein in very old patients with acute ischaemic stroke. J Intern Med, 258, 145–152.
  • Montaner, J., et al., 2008. Etiologic diagnosis of ischemic stroke subtypes with plasma biomarkers. Stroke, 39, 2280–2287.
  • Mozaffarian, D., American Heart Association Statistics Committee; Stroke Statistics Subcommittee., et al., 2016. Heart disease and stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation, 133, e38–e60.
  • Muiño, E., et al., 2015. An inflammatory polymorphisms risk scoring system for the differentiation of ischemic stroke subtypes. Mediators Inflamm, 2015, 569714.
  • Nakase, T., et al., 2008. The impact of inflammation on the pathogenesis and prognosis of ischemic stroke. J Neurol Sci, 271, 104–109.
  • Parnetti, L., et al., 2004. Mild hyperhomocysteinemia is a risk-factor in all etiological subtypes of stroke. Neurol Sci, 25, 13–17.
  • Perini, F., et al., 2005. Elevated plasma homocysteine in acute stroke was not associated with severity and outcome: stronger association with small artery disease. Neurol Sci, 26, 310–318.
  • Pietroiusti, A., et al., 2002. Cytotoxin-associated gene-A-positive Helicobacter pylori strains are associated with atherosclerotic stroke. Circulation, 106, 580–584.
  • Poggesi, A., et al., 2016. Circulating biologic markers of endothelial dysfunction in cerebral small vessel disease: a review. J Cereb Blood Flow Metab, 36, 72–94.
  • Purroy, F., et al., 2014. N-terminal pro-brain natriuretic peptide level determined at different times identifies transient ischaemic attack patients with atrial fibrillation. Eur J Neurol, 21, 679–683.
  • Rajeshwar, K., et al., 2012. C-reactive protein and nitric oxide levels in ischemic stroke and its subtypes: correlation with clinical outcome. Inflammation, 35, 978–984.
  • Ribo, M., et al., 2004. Role of homocysteine in the acute phase of stroke. Neurologia, 19, 10–14.
  • Ridker, P.M., et al., 1997. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med, 336, 973–979.
  • Shibazaki, K., et al., 2009. Plasma brain natriuretic peptide can be a biological marker to distinguish cardioembolic stroke from other stroke types in acute ischemic stroke. Intern Med, 48, 259–264.
  • Sonneveld, M.A., et al., 2013. Relationship of Von Willebrand Factor with carotid artery and aortic arch calcification in ischemic stroke patients. Atherosclerosis, 230, 210–215.
  • Terruzzi, A., et al., 2008. C-reactive protein and aetiological subtypes of cerebral infarction. Neurol Sci, 29, 245–249.
  • Turgut, B., et al., 2011. Differences in platelet-leukocyte aggregates among subtypes of acute cerebral ischemia. J Neurol Sci, 305, 126–130.
  • Tuttolomondo, A., et al., 2012. Inflammation in ischemic stroke subtypes. Curr Pharm Des, 18, 4289–4310.
  • Tuttolomondo, A., et al., 2009. Plasma levels of inflammatory and thrombotic/fibrinolytic markers in acute ischemic strokes: relationship with TOAST subtype, outcome and infarct site. J Neuroimmunol, 215, 84–89.
  • Üstündağ, M., et al., 2010. The role of serum ferritin, pro-brain natriuretic peptide and homocysteine levels in determining ischaemic stroke subtype, severity and mortality. Hong Kong Journal of Emergency Medicine, 17, 13–21.
  • VanGilder, R.L., et al., 2014. C-reactive protein and long-term ischemic stroke prognosis. J Clin Neurosci, 21, 547–553.
  • Vila, N., et al., 2000. Proinflammatory cytokines and early neurological worsening in ischemic stroke. Stroke, 31, 2325–2329.
  • Vila, N., et al., 2000. Interaction between interleukin-6 and the natural anticoagulant system in acute stroke. J Interferon Cytokine Res, 20, 325–329.
  • Wiseman, S., et al., 2014. Blood markers of coagulation, fibrinolysis, endothelial dysfunction and inflammation in lacunar stroke versus non-lacunar stroke and non-stroke: systematic review and meta-analysis. Cerebrovasc Dis, 37, 64–75.
  • Wu, N., et al., 2015. Association of inflammatory and hemostatic markers with stroke and thromboembolic events in atrial fibrillation: a systematic review and meta-analysis. Can J Cardiol, 31, 278–286.
  • Yin, W.H., et al., 2004. Independent prognostic value of elevated high-sensitivity C-reactive protein in chronic heart failure. Am Heart J, 147, 931–938.
  • Yokokawa, H., et al., 2008. Prevalence of metabolic syndrome and serum marker levels in patients with four subtypes of cerebral infarction in Japan. J Clin Neurosci, 15, 769–773.
  • Yokote, H., et al., 2007. Acute multiple brain infarction in large-artery atherosclerosis is associated with hyperhomocyst(e)inemia. Acta Neurol Scand, 116, 243–247.
  • Zhixin, W., et al., 2013. The value of the use of plasma B-type natriuretic peptide among acute ischemic stroke patients in a Chinese emergency department. Clin Neurol Neurosurg, 115, 1671–1676.

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