Advanced search
Publication Cover
Biomarkers Volume 23, 2018 - Issue 2
Submit an article Journal homepage
353
Views
9
CrossRef citations to date
0
Altmetric
Research Article

Role of IL-1ra and Granzyme B as biomarkers in active Crohn’s disease patients

Tae Jun KimDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; View further author information
,
Ja Seol KooDepartment of Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, South Korea; View further author information
,
Sung Jin KimDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; View further author information
,
Sung Noh HongDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; View further author information
,
You Sun KimDepartment of Medicine, Inje University College of Medicine, Seoul, South Korea; View further author information
,
Suk-Kyun YangDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaView further author information
&
Young-Ho KimDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Correspondence[email protected]
View further author information
 show all
Pages 161-166 | Received 07 Apr 2017, Accepted 01 Oct 2017, Published online: 16 Oct 2017

References

  • Arend, W.P., and Guthridge, C.J., 2000. Biological role of interleukin 1 receptor antagonist isoforms. Annals of the rheumatic diseases, 59(Suppl1), i60–i64.
  • Casini-Raggi, V., et al., 1995. Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation. Journal of immunology, 154, 2434–2440.
  • Florholmen, J., and Fries, W., 2011. Candidate mucosal and surrogate biomarkers of inflammatory bowel disease in the era of new technology. Scandinavian journal of gastroenterology, 46, 1407–1417.
  • Hyams, J.S., et al., 1994. Characterization of circulating interleukin-1 receptor antagonist expression in children with inflammatory bowel disease. Digestive diseases and sciences, 39, 1893–1899.
  • Iida, N., and Grotendorst, G.R., 1990. Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. Molecular and cellular biology, 10, 5596–5599.
  • Jenkins, D., et al., 2000. Differential levels of Granzyme B, regulatory cytokines, and apoptosis in Crohn's disease and ulcerative colitis at first presentation. Journal of pathology, 190, 184–189.
  • Kaser, A., Zeissig, S., and Blumberg, R.S., 2010. Inflammatory bowel disease. Annual review of immunology, 28, 573–621.
  • Leal, R.F., et al., 2015. Identification of inflammatory mediators in patients with Crohn’s disease unresponsive to anti-TNFalpha therapy. Gut, 64, 233–242.
  • Loukinova, E., et al., 2000. Growth regulated oncogene-alpha expression by murine squamous cell carcinoma promotes tumor growth, metastasis, leukocyte infiltration and angiogenesis by a host CXC receptor-2 dependent mechanism. Oncogene, 19, 3477–3486.
  • Merger, M., et al., 2002. Defining the roles of perforin, Fas/FasL, and tumour necrosis factor alpha in T cell induced mucosal damage in the mouse intestine. Gut, 51, 155–163.
  • Mitsuyama, K., et al., 2006. Increased circulating concentrations of growth-related oncogene (GRO)-alpha in patients with inflammatory bowel disease. Digestive diseases and sciences, 51, 173–177.
  • Mittal, R.D., Bid, H.K., and Ghoshal, U.C., 2005. IL-1 receptor antagonist (IL-1Ra) gene polymorphism in patients with inflammatory bowel disease in India. Scandinavian journal of gastroenterology, 40, 827–831.
  • Nakamura, M., et al., 1992. Cytokine production in patients with inflammatory bowel disease. Gut, 33, 933–937.
  • Nathan, C., 2006. Neutrophils and immunity: challenges and opportunities. Nature reviews immunology, 6, 173–182.
  • Neuman, M.G., 2007. Immune dysfunction in inflammatory bowel disease. Translational research, 149, 173–186.
  • Neurath, M.F., 2014. Cytokines in inflammatory bowel disease. Nature reviews immunology, 14, 329–342.
  • Strober, W., Fuss, I., and Mannon, P., 2007. The fundamental basis of inflammatory bowel disease. Journal of clinical investigation, 117, 514–521.
  • Tountas, N.A., et al., 1999. Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in ulcerative colitis. Gastroenterology, 117, 806–813.
  • Velikova, T., et al., 2017. Alterations in cytokine gene expression profile in colon mucosa of Inflammatory Bowel Disease patients on different therapeutic regimens. Cytokine, 92, 12–19.
  • Ye, B.D., et al., 2009. Diagnostic guideline of Crohn’s disease. Korean journal of gastroenterology, 53, 161–176.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.