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Biomarkers Volume 24, 2019 - Issue 2
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Original Articles

Monic acid A: a biomarker in clinical intra-nasal mupirocin medication for MRSA decolonisation

Theo O. DareInvestigative Safety and Drug Metabolism, GlaxoSmithKline R&D, Ware, Hertfordshire, UK;
,
Andrew W. NichollsBioimaging, GlaxoSmithKline R&D, Stevenage, Hertfordshire, UK;
&
Peter G. MantleCentre for Environmental Policy, Imperial College London, South Kensington, London, UKCorrespondence[email protected]
Pages 131-133 | Received 12 Mar 2018, Accepted 12 Aug 2018, Published online: 25 Oct 2018

References

  • Anon, a. Bactroban Nasal Drug Information User Reviews. Available from: https://www.rxlist.com/bactroban-nasal-drug.htm [Accessed 7 Oct 2017].
  • Anon, b. PGEU Statement on Antibiotic Resistance. Available from: http://www.pgeu.eu/policy/6:antibiotic-resistance.html [Accessed 9 Oct 2017].
  • Bertino, J.S., 1997. Intranasal mupirocin for outbreaks of methicillin-resistant Staphylococcus aureus. American journal of health-System Pharmacy, 54, 2185–2191.
  • Clayton, J.P., Luk, K., and Rogers, N.H., 1979. The chemistry of pseudomonic acid. Part 2. The conversion of pseudomonic acid A into monic acid A and its esters. Journal of the chemical society Perkin transactions 1, 308–313.
  • Everett, J.R., and Tyler, J.W., 1985. A nuclear magnetic resonance study of the solution conformations of the antibiotic pseudomonic acid A. Journal of the chemical society Perkin transactions 2, 871–877.
  • Fuller, A.T., et al., 1971. Pseudomonic acid: an antibiotic produced by Pseudomonas fluorescens. Nature, 234 (5329), 416–417.
  • Haidar, E.A.C., et al., 2011. HPLC/MS/MS methodology for sensitive quantitation of monic acid A, the metabolic product of the antibiotic mupirocin. Biomarkers, 16 (5), 422–425.
  • Hill, R.L.R., 2002. The bioavailability of mupirocin in nasal secretions in vitro. Journal of clinical pathology, 55 (3), 233–235.
  • Hughes, J., and Mellows, G., 1978. Inhibition of isoleucyl-transfer ribonucleic acid synthetase in Escherichia coli by pseudomonic acid . The biochemical journal, 176 (1), 305–318.
  • Seah, C., et al., 2012. MupB, a new high-level mupirocin resistance mechanism in Staphylococcus aureus. Antimicrobial agents and chemotherapy, 56 (4), 1916–1920.

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