Enhanced clinical phenotyping by mechanistic bioprofiling in heart failure with preserved ejection fraction: insights from the MEDIA-DHF study (The Metabolic Road to Diastolic Heart Failure)

References

• Almontashiri, N.A., et al., 2014. Plasma PCSK9 levels are elevated with acute myocardial infarction in two independent retrospective angiographic studies. PLoS One, 9 (9), e106294.
   PubMed Web of Science ®Google Scholar
• Arcopinto, M., et al., 2017. Growth hormone deficiency is associated with worse cardiac function, physical performance, and outcome in chronic heart failure: insights from the T.O.S.CA. GHD Study. PLoS One, 12 (1), e0170058.
   PubMed Web of Science ®Google Scholar
• Bayes-Genis, A., et al., 2017. The PCSK9-LDL receptor axis and outcomes in heart failure: BIOSTAT-CHF subanalysis. Journal of the American college of cardiology, 70 (17), 2128–2136.
   PubMed Web of Science ®Google Scholar
• Berezin, A.E., et al., 2016. Pattern of endothelial progenitor cells and apoptotic endothelial cell-derived microparticles in chronic heart failure patients with preserved and reduced left ventricular ejection fraction. EBioMedicine, 4, 86–94.
   PubMed Web of Science ®Google Scholar
• Blanco-Colio, L.M., 2014. TWEAK/Fn14 axis: a promising target for the treatment of cardiovascular diseases. Frontiers in immunology, 5, 3.
   PubMed Web of Science ®Google Scholar
• Brankovic, M., et al., 2018. Utility of temporal profiles of new cardio-renal and pulmonary candidate biomarkers in chronic heart failure. International journal of cardiology, 276:157–165.
   PubMed Web of Science ®Google Scholar
• Calderone, A., Castagnoli, L., and Cesareni, G., 2013. mentha: a resource for browsing integrated protein-interaction networks. Nature methods, 10 (8), 690–691.
   PubMed Web of Science ®Google Scholar
• Chatr-Aryamontri, A., et al., 2017. The BioGRID interaction database: 2017 update. Nucleic acids research, 45 (D1), D369–D379.
   PubMed Web of Science ®Google Scholar
• Chen, H.N., et al., 2012. TWEAK/Fn14 promotes the proliferation and collagen synthesis of rat cardiac fibroblasts via the NF-small ka, CyrillicB pathway. Molecular biology reports, 39 (8), 8231–8241.
   PubMed Web of Science ®Google Scholar
• Chioncel, O., et al., 2017. Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: an analysis of the ESC Heart Failure Long-Term Registry. European journal of heart failure, 19 (12), 1574–1585.
   PubMed Web of Science ®Google Scholar
• Chong, A.Y., et al., 2004. Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure. Journal of the American college of cardiology, 43 (3), 423–428.
   PubMed Web of Science ®Google Scholar
• Czucz, J., et al., 2011. Serum soluble E-selectin and NT-proBNP levels additively predict mortality in diabetic patients with chronic heart failure. Clinical research in cardiology, 100 (7), 587–594.
   PubMed Web of Science ®Google Scholar
• Damman, K., et al., 2014. Renal impairment, worsening renal function, and outcome in patients with heart failure: an updated meta-analysis. European heart journal, 35 (7), 455–469.
   PubMed Web of Science ®Google Scholar
• Dankiewicz, J., et al., 2013. Heparin-binding protein: an early indicator of critical illness and predictor of outcome in cardiac arrest. Resuscitation, 84 (7), 935–939.
   PubMed Web of Science ®Google Scholar
• Dehm, S.M. and Bonham, K., 2004. SRC gene expression in human cancer: the role of transcriptional activation. Biochemistry and cell biology, 82 (2), 263–274.
   PubMedGoogle Scholar
• Diny, N.L., et al., 2016. Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart. European journal of immunology, 46 (12), 2749–2760.
   PubMed Web of Science ®Google Scholar
• Economou, E., et al., 2001. Chemokines in patients with ischaemic heart disease and the effect of coronary angioplasty. International journal of cardiology, 80 (1), 55–60.
   PubMed Web of Science ®Google Scholar
• Fabregat, A., et al., 2018. The reactome pathway knowledgebase. Nucleic acids research, 46 (D1), D649–D655.
   PubMed Web of Science ®Google Scholar
• Ferraccioli, G. and Gremese, E., 2017. B cell activating factor (BAFF) and BAFF receptors: fakes and facts. Clinical and experimental immunology, 190 (3), 291–292.
   PubMed Web of Science ®Google Scholar
• Franssen, C., et al., 2016. Myocardial microvascular inflammatory endothelial activation in heart failure with preserved ejection fraction. JACC: heart failure, 4 (4), 312–324.
   PubMed Web of Science ®Google Scholar
• Frazer, J.K., et al., 2000. Identification of centerin: a novel human germinal center B cell-restricted serpin. European journal of immunology, 30 (10), 3039–3048.
   PubMed Web of Science ®Google Scholar
• Gautam, N., et al., 2001. Heparin-binding protein (HBP/CAP37): a missing link in neutrophil-evoked alteration of vascular permeability. Nature medicine, 7 (10), 1123–1127.
   PubMed Web of Science ®Google Scholar
• Hage, C., et al., 2017. Inflammatory biomarkers predict heart failure severity and prognosis in patients with heart failure with preserved ejection fraction: a holistic proteomic approach. Circulation: cardiovascular genetics, 10 (1), e001633.
   PubMedGoogle Scholar
• Hamann, J., et al., 2015. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Pharmacological reviews, 67 (2), 338–367.
   PubMed Web of Science ®Google Scholar
• He, Q. and LaPointe, M.C., 2001. Src and Rac mediate endothelin-1 and lysophosphatidic acid stimulation of the human brain natriuretic peptide promoter. Hypertension, 37 (2), 478–484.
   PubMed Web of Science ®Google Scholar
• Huang, K.Y. and Lin, H.H., 2018. The activation and signaling mechanisms of GPR56/ADGRG1 in melanoma cell. Frontiers in oncology, 8, 304.
   PubMed Web of Science ®Google Scholar
• Huang, R.B. and Eniola-Adefeso, O., 2012. Shear stress modulation of IL-1beta-induced E-selectin expression in human endothelial cells. PLoS one, 7 (2), e31874.
   PubMed Web of Science ®Google Scholar
• Huttin, O., et al., 2017. Impact of changes in consensus diagnostic recommendations on the echocardiographic prevalence of diastolic dysfunction. Journal of the American college of cardiology, 69 (25), 3119–3121.
   PubMed Web of Science ®Google Scholar
• Hwang, S.J., Melenovsky, V., and Borlaug, B.A., 2014. Implications of coronary artery disease in heart failure with preserved ejection fraction. Journal of the American college of cardiology, 63 (25), 2817–2827.
   PubMed Web of Science ®Google Scholar
• Ikezoe, K., et al., 2006. Expression of granulysin in polymyositis and inclusion-body myositis. Journal of neurology, neurosurgery & psychiatry, 77 (10), 1187–1190.
   PubMed Web of Science ®Google Scholar
• Ivetic, A., 2018. A head-to-tail view of L-selectin and its impact on neutrophil behaviour. Cell and tissue research, 371 (3), 437–453.
   PubMed Web of Science ®Google Scholar
• Jones, G.T., et al., 2016. Two C-C family chemokines, Eotaxin and RANTES, are novel independent plasma biomarkers for abdominal aortic aneurysm. Journal of the American heart association, 5 (5), e002993.
   PubMed Web of Science ®Google Scholar
• Kao, D.P., et al., 2015. Characterization of subgroups of heart failure patients with preserved ejection fraction with possible implications for prognosis and treatment response. European journal of heart failure, 17 (9), 925–935.
   PubMed Web of Science ®Google Scholar
• Kibbe, W.A., et al., 2015. Disease Ontology 2015 update: an expanded and updated database of human diseases for linking biomedical knowledge through disease data. Nucleic acids research, 43 (D1), D1071–D1078.
   PubMed Web of Science ®Google Scholar
• Kotsch, K., et al., 2004. Enhanced granulysin mRNA expression in urinary sediment in early and delayed acute renal allograft rejection. Transplantation, 77 (12), 1866–1875.
   PubMed Web of Science ®Google Scholar
• Kumar, J., et al., 2001. Granulysin: a novel antimicrobial. Expert opinion on investigational drugs, 10 (2), 321–329.
   PubMed Web of Science ®Google Scholar
• Lee, K.W., Lip, G.Y., and Blann, A.D., 2004. Plasma angiopoietin-1, angiopoietin-2, angiopoietin receptor tie-2, and vascular endothelial growth factor levels in acute coronary syndromes. Circulation, 110 (16), 2355–2360.
   PubMed Web of Science ®Google Scholar
• Li, X., et al., 2005. Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors. Journal of clinical investigation, 115 (1), 118–127.
   PubMed Web of Science ®Google Scholar
• Linder, A., et al., 2012. Elevated plasma levels of heparin-binding protein in intensive care unit patients with severe sepsis and septic shock. Critical care, 16 (3), R90.
   PubMed Web of Science ®Google Scholar
• Linder, A., Soehnlein, O., and Åkesson, P., 2010. Roles of heparin-binding protein in bacterial infections. Journal of innate immunity, 2 (5), 431–438.
   PubMed Web of Science ®Google Scholar
• Lu, D. and Insel, P.A., 2013. Hydrolysis of extracellular ATP by ectonucleoside triphosphate diphosphohydrolase (ENTPD) establishes the set point for fibrotic activity of cardiac fibroblasts. Journal of biological chemistry, 288 (26), 19040–19049.
   PubMed Web of Science ®Google Scholar
• Lundberg, M., et al., 2011. Homogeneous antibody-based proximity extension assays provide sensitive and specific detection of low-abundant proteins in human blood. Nucleic acids research, 39 (15), e102–e102.
   PubMed Web of Science ®Google Scholar
• Luo, R., et al., 2011. G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination. Proceedings of the national academy of sciences, 108 (31), 12925–12930.
   PubMed Web of Science ®Google Scholar
• Ma, X.L., et al., 1993. Monoclonal antibody to L-selectin attenuates neutrophil accumulation and protects ischemic reperfused cat myocardium. Circulation, 88 (2), 649–658.
   PubMed Web of Science ®Google Scholar
• Medamana, J., Clark, R.A., and Butler, J., 2017. Platelet-derived growth factor in heart failure. Handbook of experimental pharmacology, 243, 355–369.
   PubMedGoogle Scholar
• Moreno, H., Jr., et al., 1996. Chronic nitric oxide inhibition as a model of hypertensive heart muscle disease. Basic research in cardiology, 91 (3), 248–255.
   PubMed Web of Science ®Google Scholar
• Morrison, A.C., et al., 2008. Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study. Cerebrovascular diseases, 26 (4), 420–424.
   PubMed Web of Science ®Google Scholar
• Nagasawa, M., et al., 2007. Serum granulysin is elevated in patients with hemophagocytic lymphohistiocytosis. International journal of hematology, 86 (5), 470–473.
   PubMed Web of Science ®Google Scholar
• Ong, K.L., et al., 2019. High plasma FGF21 levels predicts major cardiovascular events in patients treated with atorvastatin (from the Treating to New Targets [TNT] Study). Metabolism, 93, 93–99.
   PubMed Web of Science ®Google Scholar
• Ornitz, D.M. and Itoh, N., 2015. The Fibroblast Growth Factor signaling pathway. Wiley interdisciplinary reviews: developmental biology, 4 (3), 215–266.
   PubMed Web of Science ®Google Scholar
• Pardo, J., et al., 2001. A role of the mitochondrial apoptosis-inducing factor in granulysin-induced apoptosis. The journal of immunology, 167 (3), 1222–1229.
   PubMed Web of Science ®Google Scholar
• Paulus, W.J., et al., 2007. How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. European heart journal, 28 (20), 2539–2550.
   PubMed Web of Science ®Google Scholar
• Persic, V., et al., 2012. Granulysin expression in lymphocytes that populate the peripheral blood and the myocardium after an acute coronary event. Scandinavian journal of immunology, 75 (2), 231–242.
   PubMed Web of Science ®Google Scholar
• Pinero, J., et al., 2017. DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants. Nucleic acids research, 45 (D1), D833–d839.
   PubMed Web of Science ®Google Scholar
• Ponikowski, P., et al., 2016. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) developed with the special contribution of the Heart Failure Association (HFA) of the ESC. European heart journal, 37 (27), 2129–2200.
   PubMed Web of Science ®Google Scholar
• Ptaszynska-Kopczynska, K., et al., 2016. Alterations of soluble TWEAK and CD163 concentrations in patients with chronic heart failure. Cytokine, 80, 7–12.
   PubMed Web of Science ®Google Scholar
• Reddy, Y.N.V., et al., 2018. A simple, evidence-based approach to help guide diagnosis of heart failure with preserved ejection fraction. Circulation, 138 (9), 861–870.
   PubMed Web of Science ®Google Scholar
• Rossignol, P., et al., 2019. Heart failure drug treatment. Lancet, 393 (10175), 1034–1044. PMID: 30860029. DOI: 10.1016/S0140-6736(18)31808-7.
   Google Scholar
• Rubin, D. B., 2004. Multiple imputation for nonresponse in surveys. New York: John Wiley and Sons.
   Google Scholar
• Sabatine, M.S., et al., 2017. Evolocumab and clinical outcomes in patients with cardiovascular disease. New England journal of medicine, 376 (18), 1713–1722.
   PubMed Web of Science ®Google Scholar
• Salzano, A., et al., 2016. Multiple hormone deficiency syndrome in heart failure with preserved ejection fraction. International journal of cardiology, 225, 1–3.
   PubMed Web of Science ®Google Scholar
• Salzano, A., et al., 2018. Growth hormone therapy in heart failure. Heart failure clinics, 14 (4), 501–515.
   PubMed Web of Science ®Google Scholar
• Sanchez-Martinez, S., et al., 2018. Machine learning analysis of left ventricular function to characterize heart failure with preserved ejection fraction. Circulation: cardiovascular imaging, 11 (4), e007138.
   PubMed Web of Science ®Google Scholar
• Sanders-van Wijk, S., et al., 2015. Circulating biomarkers of distinct pathophysiological pathways in heart failure with preserved vs. reduced left ventricular ejection fraction. European journal of heart failure, 17 (10), 1006–1014.
   PubMed Web of Science ®Google Scholar
• Santhanakrishnan, R., et al., 2012. Growth differentiation factor 15, ST2, high-sensitivity troponin T, and N-terminal pro brain natriuretic peptide in heart failure with preserved vs. reduced ejection fraction. European journal of heart failure, 14 (12), 1338–1347.
   PubMed Web of Science ®Google Scholar
• Sevigny, J., et al., 2002. Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation. Blood, 99 (8), 2801–2809.
   PubMed Web of Science ®Google Scholar
• Shah, S.J., et al., 2015. Phenomapping for novel classification of heart failure with preserved ejection fraction. Circulation, 131 (3), 269–279.
   PubMed Web of Science ®Google Scholar
• Shimada, Y.J. and Cannon, C.P., 2015. PCSK9 (Proprotein convertase subtilisin/kexin type 9) inhibitors: past, present, and the future. European heart journal, 36 (36), 2415–2424.
   PubMed Web of Science ®Google Scholar
• Slenter, D.N., et al., 2018. WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research. Nucleic acids research, 46 (D1), D661–d667.
   PubMed Web of Science ®Google Scholar
• Smith, T.L., et al., 2018. Tie2 signalling through Erk1/2 regulates TLR4 driven inflammation. Cellular signalling, 51, 211–221.
   PubMed Web of Science ®Google Scholar
• Stein, B., et al., 1998. Increased expression of constitutive nitric oxide synthase III, but not inducible nitric oxide synthase II, in human heart failure. Journal of the american college of cardiology, 32 (5), 1179–1186.
   PubMed Web of Science ®Google Scholar
• Szklarczyk, D., et al., 2015. STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic acids research, 43 (D1), D447–452. (Database issue),
   PubMed Web of Science ®Google Scholar
• Tabassian, M., et al., 2018. Diagnosis of heart failure with preserved ejection fraction: machine learning of spatiotemporal variations in left ventricular deformation. Journal of the American society of echocardiography, 31 (12), 1272.e9–1284.e9.
   Web of Science ®Google Scholar
• Tribouilloy, C., et al., 2008. Prognosis of heart failure with preserved ejection fraction: a 5 year prospective population-based study. European heart journal, 29 (3), 339–347.
   PubMed Web of Science ®Google Scholar
• Tromp, J., et al., 2017. Biomarker profiles in heart failure patients with preserved and reduced ejection fraction. Journal of the American heart association, 6 (4), e003989.
   PubMed Web of Science ®Google Scholar
• Tromp, J., et al., 2018. Identifying pathophysiological mechanisms in heart failure with reduced versus preserved ejection fraction. Journal of the American college of cardiology, 72 (10), 1081–1090.
   PubMed Web of Science ®Google Scholar
• Tsao, C.W., et al., 2018. Temporal trends in the incidence of and mortality associated with heart failure with preserved and reduced ejection fraction. JACC: heart failure, 6 (8), 678–685.
   PubMed Web of Science ®Google Scholar
• Tsiantoulas, D., et al., 2018. B cell-activating factor neutralization aggravates atherosclerosis. Circulation, 138 (20), 2263–2273.
   PubMed Web of Science ®Google Scholar
• The UniProt Consortium. UniProt: the universal protein knowledgebase. 2017. Nucleic acids research, 45 (D1), D158–d169.
   PubMed Web of Science ®Google Scholar
• Vedin, O., et al., 2017. Significance of ischemic heart disease in patients with heart failure and preserved, midrange, and reduced ejection fraction: a nationwide cohort study. Circulation: heart failure, 10 (6), e003875.
   PubMed Web of Science ®Google Scholar
• Vitello, A.M., et al., 2012. Serendipitous discovery of a novel protein signaling mechanism in heart failure. Biochemical and biophysical research communications, 421 (3), 431–435.
   PubMed Web of Science ®Google Scholar
• Williams, T.J., 2015. Eotaxin-1 (CCL11). Frontiers in immunology, 6, 84.
   PubMed Web of Science ®Google Scholar
• Woo, Y.C., et al., 2013. Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives. Clinical endocrinology, 78 (4), 489–496.
   PubMed Web of Science ®Google Scholar
• Zannad, F. and Rossignol, P., 2018. Cardiorenal syndrome revisited. Circulation, 138 (9), 929–944.
   PubMed Web of Science ®Google Scholar
• Zouggari, Y., et al., 2013. B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction. Nature medicine, 19 (10), 1273–1280.
   PubMed Web of Science ®Google Scholar
• Zymek, P., et al., 2006. The role of platelet-derived growth factor signaling in healing myocardial infarcts. Journal of the American college of cardiology, 48 (11), 2315–2323.
   PubMed Web of Science ®Google Scholar