The myostatin rs1805086 variant is associated with obesity in Mexican adults, independently of metabolic risk factors

References

• Amor, M., et al., 2019. Serum myostatin is upregulated in obesity and correlates with insulin resistance in humans. Experimental and clinical endocrinology & diabetes: official journal, *German society of endocrinology [and] German diabetes association, 127 (8), 550–556.
   PubMed Web of Science ®Google Scholar
• Babcock, L.W., Knoblauch, M., and Clarke, M.S.F., 2015. The role of myostatin and activin receptor IIB in the regulation of unloading-induced myofiber type-specific skeletal muscle atrophy. Journal of applied physiology, 119 (6), 633–642.
   PubMed Web of Science ®Google Scholar
• Bhatt, S.P., et al., 2012. Association of the Myostatin gene with obesity, abdominal obesity and low lean body mass and in non-diabetic Asian Indians in north India. PLoS one, 7 (8), e40977.
   PubMed Web of Science ®Google Scholar
• Carvalho, L.P., et al., 2018. Myostatin and adipokines. The role of the metabolically unhealthy obese phenotype in muscle function and aerobic capacity in young adults. Cytokine, 107, 118–124.
   PubMed Web of Science ®Google Scholar
• Deng, B., et al., 2017. The function of myostatin in the regulation of fat mass in mammals. Nutrition & metabolism, 14, 29.
   PubMed Web of Science ®Google Scholar
• Di Rocco, G., et al., 2006. Myogenic potential of adipose-tissue-derived cells. Journal of cell science, 119 (Pt 14), 2945–2952.
   PubMed Web of Science ®Google Scholar
• Feldman, B.J., et al., 2006. Brian J. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proceedings of the national academy of sciences of the United States of America, 103 (42), 15675–15680.
   PubMed Web of Science ®Google Scholar
• Fernández-Santander, A., et al., 2012. Polymorphisms influencing muscle phenotypes in North-African and Spanish populations. Annals of human biology, 39 (2), 166–169.
   PubMed Web of Science ®Google Scholar
• Fuku, N., et al., 2016. Muscle-Related Polymorphisms (MSTN rs1805086 and ACTN3 rs1815739) are not associated with exceptional longevity in Japanese Centenarians. PLoS one, 11 (11), e0166605.
   PubMed Web of Science ®Google Scholar
• Gallagher, D., et al., 2000. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. The American journal of clinical nutrition, 72 (3), 694–701.
   PubMed Web of Science ®Google Scholar
• Gesta, S., Tseng, Y.H., and Kahn, C.R., 2007. Developmental origin of fat: tracking obesity to its source. Cell, 131 (2), 242–256.
   PubMed Web of Science ®Google Scholar
• Guo, W., et al., 2008. The effects of myostatin on adipogenic differentiation of human bone marrow-derived mesenchymal stem cells are mediated through cross-communication between Smad3 and Wnt/beta-catenin signaling pathways. The journal of biological chemistry, 283 (14), 9136–9145.
   PubMed Web of Science ®Google Scholar
• Herrera, B.M. and Lindgren, C.M., 2010. The genetics of obesity. Current diabetes reports, 10 (6), 498–505.
   PubMed Web of Science ®Google Scholar
• Hittel, D.S., et al., 2009. Increased secretion and expression of myostatin in skeletal muscle from extremely obese women. Diabetes, 58 (1), 30–38.
   PubMed Web of Science ®Google Scholar
• Huang, Z., Chen, X., and Chen, D., 2011. Myostatin: a novel insight into its role in metabolism, signal pathways, and expression regulation. Cellular signalling, 23 (9), 1441–1446.
   PubMed Web of Science ®Google Scholar
• Kim, C.H., et al., 2011. Norm references of fat-free mass index and fat mass index and subtypes of obesity based on the combined FFMI-%BF indices in the Korean adults aged 18–89 yr. Obesity research & clinical practice, 5, e210–e219.
   Web of Science ®Google Scholar
• Kostek, M.A., et al., 2009. Myostatin and follistatin polymorphisms interact with muscle phenotypes and ethnicity. Medicine and science in sports and exercise, 41, 1063–1071.
   Google Scholar
• Lee, S.J., 2004. Regulation of muscle mass by myostatin. Annual review of cell and developmental biology, 20, 61–86.
   PubMed Web of Science ®Google Scholar
• Lee, S.-J. and McPherron, A., 2001. Regulation of myostatin activity and muscle growth. Proceedings of the national academy of sciences of the United States of America, 98 (16), 9306–9311.
   PubMed Web of Science ®Google Scholar
• Li, N., et al., 2016. Myostatin attenuation in vivo reduces adiposity, but activates adipogenesis. Endocrinology, 157 (1), 282–291.
   PubMed Web of Science ®Google Scholar
• Li, X., et al., 2014. The A55T and K153R polymorphisms of MSTN gene are associated with the strength training-induced muscle hypertrophy among Han Chinese men. Journal of sports sciences, 32 (9), 883–891.
   PubMed Web of Science ®Google Scholar
• Liu, X.-H., Bauman, W. A., and Cardozo, C. P., 2018. Myostatin inhibits glucose uptake via suppression of insulin-dependent and-independent signaling pathways in myoblasts. Physiological Reports, 6 (17), e13837.
   PubMed Web of Science ®Google Scholar
• McPherron, A.C., 2010. Metabolic functions of myostatin and GDF11. Immunology, endocrine & metabolic agents in medicinal chemistry, 10 (4), 217–231.
   PubMedGoogle Scholar
• Mora-García, G.J., et al., 2014. Anthropometric parameters' cut-off points and predictive value for metabolic syndrome in women from Cartagena, Colombia. Salud publica de Mexico, 56 (2), 146–153.
   PubMed Web of Science ®Google Scholar
• Peltz, G., et al., 2010. The role of fat mass index in determining obesity. American journal of human biology, 22 (5), 639–647.
   PubMed Web of Science ®Google Scholar
• Ryan, A.S., et al., 2013. Aerobic exercise + weight loss decreases skeletal muscle myostatin expression and improves insulin sensitivity in older adults. Obesity, 21 (7), 1350–1356.
   PubMed Web of Science ®Google Scholar
• Santiago, C., et al., 2011. The K153R polymorphism in the myostatin gene and muscle power phenotypes in young, non-athletic men. PLoS one, 6 (1), e16323.
   PubMed Web of Science ®Google Scholar
• Saunders, M.A., et al., 2006. Human adaptive evolution at Myostatin (GDF8), a regulator of muscle growth. American journal of human genetics, 79 (6), 1089–1097.
   PubMed Web of Science ®Google Scholar
• Seibert, M.J., et al., 2001. Polymorphic variation in the muman Myostatin (GDF-8) gene and association with strength measures in the women's health and aging study II cohort. Journal of the American geriatrics society, 49 (8), 1093–1096.
   Google Scholar
• Shamah, T., et al., 2016. Encuesta Nacional de Salud y Nutrición 2016. Cuernavaca, México: Instituto Nacional de Salud Pública. http://ensanut.insp.mx Accessed 15 March 2019.
   Google Scholar
• Solanki, J.D., et al., 2015. Body composition in type 2 diabetes: change in quality and not just quantity that matters. International journal of preventive medicine, 6, 122.
   PubMed Web of Science ®Google Scholar
• Szláma, G., et al., 2015. K153R polymorphism in myostatin gene increases the rate of promyostatin activation by furin. FEBS letters, 589 (3), 295–301.
   PubMed Web of Science ®Google Scholar
• Wang, D., et al., 2011. Ethnic differences in body composition and obesity related risk factors: study in Chinese and white males living in China. PLoS one, 6 (5), e19835.
   PubMed Web of Science ®Google Scholar
• Woolcott, O.O. and Bergman, R.N., 2018. Relative fat mass (RFM) as a new estimator of whole-body fat percentage ─ a cross-sectional study in American adult individuals . Scientific reports, 8 (1), 10980.
   PubMedGoogle Scholar
• Yang, X., Bi, P., and Kuang, S., 2014. Fighting obesity: when muscle meets fat. Adipocyte, 3 (4), 280–289.
   PubMedGoogle Scholar
• Yue, H., et al., 2012. Contribution of myostatin gene polymorphisms to normal variation in lean mass, fat mass and peak BMD in Chinese male offspring. Acta pharmacologica sinica, 33 (5), 660–667.
   PubMed Web of Science ®Google Scholar