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Biomarkers Volume 27, 2022 - Issue 2
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Original Articles

Ameliorative effect of flavonoid-rich extracts from Gongronema latifolium against diabetic cardiomyopathy via serpin A3 and socs3-a in streptozocin treated rats

Babatunji Emmanuel Oyinloyea Phytomedicine, Biochemical Toxicology and Biotechnology Research Laboratories, Department of Biochemistry, College of Sciences, Afe Babalola University, Ado-Ekiti, Nigeria;b Institute of Drug Research and Development, SE Bogoro Center, Afe Babalola University, Ado-Ekiti, Nigeria;c Biotechnology and Structural Biology (BSB) Group, Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, South AfricaORCID Iconhttps://orcid.org/0000-0003-2165-7936
ORCID Icon,
Basiru Olaitan Ajiboyeb Institute of Drug Research and Development, SE Bogoro Center, Afe Babalola University, Ado-Ekiti, Nigeria;d Phytomedicine and Molecular Toxicology Research Laboratory, Department of Biochemistry, Federal University Oye-Ekiti, Oye-Ekiti, NigeriaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-5982-2322
ORCID Icon,
Oluwafolakemi Johnsona Phytomedicine, Biochemical Toxicology and Biotechnology Research Laboratories, Department of Biochemistry, College of Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
,
Olutunmise Victoria Owolabie Medical Biochemistry Unit, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
,
Jerius Nkwuda Ejejea Phytomedicine, Biochemical Toxicology and Biotechnology Research Laboratories, Department of Biochemistry, College of Sciences, Afe Babalola University, Ado-Ekiti, Nigeria;f Department of Chemistry/Biochemistry/Molecular Biology, Alex- Ekwueme Federal University Ndufu-Alike, Abakaliki, Nigeria
,
Bartholomew I. C. Braig Department of Biochemistry, Federal University Oye-Ekiti, Oye-Ekiti, Nigeria
&
Olaposi Idowu Omotuyib Institute of Drug Research and Development, SE Bogoro Center, Afe Babalola University, Ado-Ekiti, Nigeria;h Department of Pharmacceutical Science, Faculty of Pharmacy, Afe Babalola University, Ado-Ekiti, Nigeria
 show all
Pages 169-177 | Received 23 Nov 2021, Accepted 21 Dec 2021, Published online: 25 Jan 2022

References

  • Ajiboye, B.O., et al., 2018. Anti-hyperglycemic and anti-inflammatory activities of polyphenolic-rich extract of Syzygium cumini linn leaves in alloxan-induced diabetic rats. Journal of evidence-based integrative medicine, 23, 1–30.
  • Ajiboye, B.O., et al., 2019. Antihyperglycaemia and related gene expressions of aqueous extract of Gongronema latifolium leaf in alloxan-induced diabetic rats. Pharmaceutical biology, 57 (1), 604–611.
  • Balestrino, M., 2021. Role of creatine in the heart: health and disease. Nutrients, 13 (4), 1215.
  • Braunwald, E., and Bristow, M.R., 2000. Congestive heart failure: fifty years of progress. Circulation, 102 (20 Suppl 4), IV14–23.
  • Dobrin, J.S., and Lebeche, D., 2010. Diabetic cardiomyopathy: signaling defects and therapeutic approaches. Expert review of cardiovascular therapy, 8 (3), 373–391.
  • ElSayed, A.I., et al., 2021. Exogenous melatonin enhances the reactive oxygen species metabolism, antioxidant defense-related gene expression, and photosynthetic capacity of Phaseolus vulgaris L. to confer salt stress tolerance. Physiologia plantarum, 173 (4):1369–1381.
  • Ferrario, C.M., and Strawn, W.B., 2006. Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease. The American journal of cardiology, 98 (1), 121–128.
  • Gindele, R., et al., 2021. Investigation of the differences in antithrombin to heparin binding among antithrombin budapest 3, basel, and padua mutations by biochemical and in silico methods. Biomolecules, 11 (4), 544.
  • Ingwersen, T. F. (2020). Using small chemical compounds to inhibit polymerization of neuroserpin in FENIB (Doctoral dissertation, Staats-und Universitätsbibliothek Hamburg Carl von Ossietzky).
  • Jia, G., Hill, M.A., and Sowers, J.R., 2018. Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity. Circulation research, 122 (4), 624–638.
  • Kinosian, B., Glick, H., and Garland, G., 1994. Cholesterol and coronary heart disease: predicting risks by levels and ratios. Annals of internal medicine, 121 (9), 641–647.
  • Liu, W., et al., 2018. Spironolactone protects against diabetic cardiomyopathy in streptozotocin-induced diabetic rats. Journal of diabetes research, 2018, 9232065.
  • Mohamed, N.A., and Nassier, O.A., 2013. The antihyperglycaemic effect of the aqueous extract of Origanum vulgare leaves in streptozotocin-induced diabetic rats. Jordan journal of biological sciences, 6 (1), 31–38.
  • Morebise, O., et al., 2002. Anti-inflammatory property of Gongronema latifolium. Phytotherapy research, 16 (S1), 75–577.
  • Obafemi, T.O., et al., 2017. Antidiabetic potential of methanolic and flavonoid-rich leaf extracts of Synsepalum dulcificum in type 2 diabetic rats. Journal of ayurveda and integrative medicine, 8 (4), 238–246.
  • Ozougwu, J.C., et al., 2013. The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus. Journal of physiology and pathophysiology, 4 (4), 46–57.
  • Raza, H., et al., 2000. Modulation of xenobiotic metabolism and oxidative stress in chronic streptozotocin-induced diabetic rats fed with Momordica charantia fruit extract. Journal of biochemical and molecular toxicology, 14 (3), 131–139.
  • Ross, M. H., and Wojciech, M. D. P., 2006. Histology: a text and atlas with correlated cell and molecular biology (Histology (Ross)), 5th Edition. Philadelphia: Lippincott Williams & Wilkins.
  • Santos, A.D.S.E., et al., 2021. Exposure to pesticides and oxidative stress in Brazilian agricultural communities. Biomarkers, 26 (6), 539–547.
  • Seong, R.K., Lee, J.K., and Shin, O.S., 2020. Zika virus-induction of the suppressor of cytokine signaling 1/3 contributes to the modulation of viral replication. Pathogens, 9 (3), 163.
  • Song, X., et al., 2020. Self-anticoagulant nanocomposite spheres for the removal of bilirubin from whole blood: a step toward a wearable artificial liver. Biomacromolecules, 21 (5), 1762–1775.
  • Ugochukwu, W.H., et al., 2003. The effect of Gongronema latifolium extracts on serum lipid profile and oxidative stress in hepatocytes of diabetic rats. Journal of biosciences, 28 (1), 1–5.
  • Wall, P.M.L., et al., 1994. Increase of high-density lipoprotein cholesterol at ovulation in healthy women. Atherosclerosis, 105 (2), 171–178.
  • Yilmaz, S., et al., 2015. Diabetic cardiomyopathy; summary of 41 years. Korean circulation journal, 45 (4), 266–272. 2015.

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